Acute hepatitis A

AB1_HEPATITIS_A

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B15 Hospital discharge: ICD-9 — 070[0-1] Cause of death: ICD-10 — B15 Cause of death: ICD-9 — 070[0-1] 2 out of 7 registries used, show all original rules.	161
4. Check minimum number of events None	161
5. Include endpoints None	161
6. Filter based on genotype QC (FinnGen only)	148

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: B15-B19
Name in latin: Hepatitis A acuta

NAME	AB1_HEPATITIS_A
CONTROL_EXCLUDE	AB1_VIRAL_HEPATITIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B15
HD_ICD_9	070[0-1]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B15
COD_ICD_9	070[0-1]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute hepatitis A based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1602	688	896
Only index persons	1328	598	730
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	36.85	37.94	35.93
Only index persons	34.38	35.37	33.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	148	74	74
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	39.62	38.88	40.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
161: Matched controls
1610

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B15.9

ICD-10 Finland

Hepatitis A without hepatic coma

+∞

114.7

0701A

ICD-9 Finland

Viral hepatitis A without mention of hepatic coma

+∞

55.5

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

64.3

23.9

B18.2

ICD-10 Finland

Chronic viral hepatitis C

+∞

15.9

0700A

ICD-9 Finland

Viral hepatitis A with hepatic coma

+∞

10.5

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

+∞

8.4

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.8

7.5

WYA30

NOMESCO Finland

Treatment of a patient needing special arrangements

4.0

7.5

F15.2

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome

+∞

7.3

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

13.0

6.7

N05BA02

ATC

chlordiazepoxide; systemic

11.7

6.4

B15.0

ICD-10 Finland

Hepatitis A with hepatic coma

+∞

6.3

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.8

6.0

140

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

101

689

2.25

5.73

7.6

6.4

11.39

11.01

umol/l

0.16

654

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

16.72

5.47

1.7

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.39

5.02

1.0

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.71

4.02

1.1

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

12.39

3.79

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.61

3.18

3.9

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.75

2.97

4.4

2.5

—

(3019198) Lymphocytes [#/volume] in Blood

703

1.72

2.85

7.1

6.2

2.18

1.83

e9/l

0.64

635

(3013115) Eosinophils [#/volume] in Blood

703

1.68

2.63

7.3

6.5

0.21

0.18

e9/l

0.74

629

(40758558) Short blood count panel - Blood

346

1.74

2.62

9.1

7.8

—

(3044290) Cell count panel - Cerebral spinal fluid

4.15

2.60

2.3

1.4

—

(3021589) Normoblasts [#/volume] in Blood

599

1.67

2.60

12.2

9.8

0.00

e9/l

0.50

490

(3022217) INR in Platelet poor plasma by Coagulation assay

572

1.66

2.57

12.2

11.4

1.15

1.22

inr

0.20

179

(3026389) Candida sp identified in Specimen by Organism specific culture

5.62

2.56

3.8

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

103

2.19

2.55

2.2

2.4

11.69

10.25

g/l

0.63

(3021879) Hepatitis B virus core Ab [Presence] in Serum

125

2.08

2.52

1.6

—

(3006315) Basophils [#/volume] in Blood

680

1.65

2.50

7.3

6.3

0.05

0.04

e9/l

0.86

595

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

4.75

2.29

1.0

—

(3001604) Monocytes [#/volume] in Blood

681

1.60

2.27

7.3

6.2

0.58

0.57

e9/l

0.19

595

(3028707) Methadone [Presence] in Urine by Screen method

3.22

2.26

1.8

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

780

1.61

2.26

13.6

10.4

3.83

4.19

e9/l

1.18

691

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

177

1.85

2.22

2.0

1.8

1.57

1.42

0.32

159

(3028026) IgM [Mass/volume] in Serum or Plasma

2.15

1.2

1.7

1.11

1.12

g/l

0.00

(3015377) Calcium [Moles/volume] in Serum or Plasma

420

1.60

2.05

3.8

3.6

2.37

2.35

mmol/l

0.69

369

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

145

1.86

1.95

2.5

1.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.92

0.0

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

147

1.83

1.87

2.6

1.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

576

1.53

1.87

3.0

2.6

92.20

109.28

ug/l

0.48

529

(3013707) Erythrocyte sedimentation rate by Westergren method

115

985

1.59

1.87

4.8

4.2

13.01

10.81

mm/h

0.75

108

912

(21494815) CD4 cells/100 lymphocytes in Specimen

4.26

1.83

3.4

2.0

30.06

38.07

—

(3037522) Nuclear Ab [Titer] in Serum

188

1.73

1.83

1.2

1.4

320.00

408.70

titre

—

(3037756) Immunofixation for Serum or Plasma

3.13

1.82

1.0

2.0

—

(3026782) Osmolality of Urine

257

1.63

1.75

3.1

2.8

511.33

547.91

mosm/kgh2o

0.43

217

(3024561) Albumin [Mass/volume] in Serum or Plasma

545

1.50

1.74

7.1

4.6

34.86

35.94

g/l

0.85

521

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.23

1.65

2.2

2.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

287

1.57

1.64

2.9

2.0

2.97

3.18

mg/l

0.24

243

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.93

1.52

1.3

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

2.45

1.48

1.3

1.2

—

(3002385) Erythrocyte distribution width [Ratio]

129

1159

1.57

1.47

25.4

16.6

14.60

14.83

0.21

129

1148

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.19

1.45

1.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

227

1.57

1.42

1.5

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

2.05

1.37

1.8

1.2

—

(3000494) Fungus identified in Specimen by Culture

162

1.64

1.36

1.2

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

146

1.67

1.35

3.0

2.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

1.33

0.0

1.5

—

(3011288) Drugs identified in Urine by Screen method

2.16

1.32

14.6

1.5

—

(3027944) Amphetamines [Presence] in Urine

2.01

1.31

1.8

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.01

1.31

1.8

1.2

—

(3027008) Opiates [Presence] in Urine

2.01

1.31

1.8

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.16

1.30

4.1

2.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.16

1.30

1.1

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.35

1.29

1.9

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.36

1.20

1.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.36

1.20

1.0

1.2

—

(3016879) Cocaine [Presence] in Urine

1.96

1.15

1.8

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.05

1.14

1.0

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

170

1.56

1.13

2.0

2.2

17.94

22.29

1.39

145

(40760892) CBC W Ordered Manual Differential panel - Blood

638

1.36

1.13

8.0

6.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

231

1.48

1.11

1.4

1.2

22.18

6.30

u/ml

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

2.00

1.10

1.9

1.5

263.75

258.16

ug/g

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

189

1.51

1.08

2.3

1.7

—

(3044889) 12 lead EKG panel

103

912

1.36

1.06

4.4

3.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

165

1.53

1.04

3.0

2.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.97

1.04

2.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

550

0.72

1.02

3.3

2.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

784

1.34

1.01

5.9

4.6

6.70

6.65

mmol/l

0.06

723

(3023368) Bacteria identified in Blood by Culture

317

1.39

0.99

6.7

4.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

150

1.54

0.99

6.3

8.0

104.77

103.67

mmol/l

0.66

150

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

2.21

0.98

4.6

1.4

804.30

167.07

u/ml

—

(3037467) Urinalysis macro (dipstick) panel - Urine

101

898

1.33

0.97

4.9

4.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

118

1.59

0.96

2.9

1.9

312.83

390.86

nmol/l

1.20

109

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

137

1280

1.47

0.95

4.7

4.4

6.09

5.90

mmol/l

0.74

131

1186

(3002179) Metamyelocytes/100 leukocytes in Blood

110

1.61

0.95

2.7

4.2

0.71

0.55

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

127

1.56

0.93

3.9

3.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

213

1.44

0.93

2.7

1.9

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.19

0.92

1.3

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.75

0.91

1.6

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.68

0.87

1.2

111.92

181.43

u/ml

0.76

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.86

0.87

1.1

2.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

352

1.34

0.86

1.6

1.7

1.56

1.39

mmol/l

0.75

292

(3018418) pH of Serum or Plasma

371

1.34

0.86

2.9

4.2

7.39

7.41

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

399

1.33

0.86

2.4

2.1

150.88

161.61

u/l

0.12

377

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.97

0.85

1.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.85

0.80

1.7

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.85

0.80

1.5

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.79

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.79

0.0

1.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

141

1336

1.45

0.78

20.0

13.7

23.19

21.31

mg/l

0.25

118

1052

(3007164) IgA [Mass/volume] in Serum or Plasma

295

1.33

0.74

1.4

2.39

2.43

g/l

0.06

178

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

591

1.26

0.71

7.5

7.3

1.22

mmol/l

0.04

503

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.95

0.71

1.0

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.95

0.71

1.0

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

106

972

1.27

0.69

3.9

3.8

14.33

14.65

pmol/l

0.59

888

(3038515) Glucose [Moles/volume] in Venous blood

1.88

0.69

3.0

3.8

6.36

8.00

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

468

1.27

0.68

3.4

3.6

25.43

68.37

e6/l

1.04

318

(3004588) Protein electrophoresis panel - Serum or Plasma

1.58

0.67

1.4

3.0

—

(3025159) Blasts/100 leukocytes in Blood

112

1.48

0.66

2.2

4.3

0.00

0.25

—

(3002582) Erythrocytes [#/volume] in Urine

403

1.27

0.66

2.8

2.9

164.33

200.28

e6/l

0.06

296

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

537

1.25

0.66

2.5

2.4

81.45

74.69

nmol/l

0.82

483

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.69

0.62

1.0

1.3

—

(3021440) Promyelocytes/100 leukocytes in Blood

114

1.45

0.61

2.8

4.4

0.00

0.15

—

(36304419) Bacteria [Presence] in Urine

360

1.27

0.61

2.8

2.7

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.61

0.0

3.7

—

(3019225) pH of Specimen

113

0.60

3.6

5.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

371

1.26

0.59

2.7

2.8

0.25

0.40

e6/l

0.62

265

(3003694) ABO and Rh group [Type] in Blood

371

1.26

0.59

1.3

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

134

1274

1.31

0.58

14.7

12.5

86.32

84.26

ml/min/173m2

0.55

117

1057

(3017181) Myelocytes/100 leukocytes in Blood

124

1.41

0.58

2.8

4.3

0.43

0.93

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

223

1.31

0.57

2.0

2.5

15.17

0.81

e6/l

0.49

120

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

149

1440

1.47

0.57

14.4

10.5

30.10

27.57

u/l

0.80

144

1399

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

143

1.37

0.55

1.9

—

(3042936) Bacteria identified in Isolate by Culture

197

1.32

0.55

1.8

1.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

243

1.29

0.55

4.0

3.5

29.68

213.12

ng/l

1.64

187

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

130

1236

1.27

0.53

6.2

5.5

39.74

39.76

mmol/mol

0.01

125

1161

(3021601) Nitrite [Presence] in Urine by Test strip

666

1.21

0.53

4.9

5.0

0.00

estimate

-0.00

126

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

126

1194

1.25

0.53

4.7

4.6

1.84

1.88

mu/l

0.15

118

1095

(3029937) Albumin [Presence] in Urine by Test strip

338

1.24

0.52

3.3

3.9

0.00

0.02

estimate

0.50

122

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.52

0.52

2.2

1.2

—

(3020891) Body temperature

1.52

0.52

2.0

4.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

292

1.25

0.51

2.9

3.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

141

1356

1.32

0.50

4.7

4.8

2.83

mmol/l

0.00

129

1266

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

143

0.68

0.50

1.5

1.7

—

(3013512) EKG study

368

0.80

0.46

4.5

3.9

—

(3000991) Gas panel - Venous blood

104

1.38

0.45

8.0

9.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

508

1.19

0.44

2.2

1.9

104.81

96.76

pmol/l

0.70

264

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

279

1.23

0.43

1.9

1.8

0.60

1.19

mg/l

1.79

224

(3020564) Creatinine [Moles/volume] in Serum or Plasma

146

1417

1.33

0.42

21.0

15.6

73.88

77.35

umol/l

1.24

146

1417

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

3.8

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

1.5

—

21.86

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.49

0.40

1.8

4.0

—

1.67

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

272

1.22

0.40

2.3

2.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.39

0.0

2.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.39

0.0

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

138

1334

1.24

0.38

4.2

4.4

4.66

4.71

mmol/l

0.17

126

1253

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

236

1.23

0.38

1.4

1.3

32.94

36.13

iu/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

208

1.24

0.38

2.2

2.7

8.04

2.27

e6/l

0.42

107

(3020682) Albumin/Creatinine [Ratio] in Urine

369

1.19

0.38

3.5

3.8

6.98

11.28

mg/mmol

0.43

234

(21494755) Public health laboratory ask at order entry panel

179

0.76

0.38

1.6

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.44

0.36

1.2

1.3

—

(3052851) Hemolysis interference index of Serum or Plasma

1.44

0.36

1.0

3.4

—

(4034850) Laboratory test

1.41

0.35

3.7

8.5

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

128

1.28

0.33

11.4

8.8

5.24

5.09

kpa

0.33

122

(3027801) Oxygen [Partial pressure] in Arterial blood

128

1.28

0.33

11.4

8.8

13.43

11.94

kpa

0.36

123

(3009261) Glucose [Presence] in Urine by Test strip

677

1.14

0.33

3.4

3.6

0.00

estimate

-0.00

121

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

142

0.76

0.32

7.5

7.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

137

1330

1.20

0.31

4.1

4.4

1.41

1.45

mmol/l

0.46

127

1239

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.36

0.31

1.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.31

0.31

3.7

3.8

48.11

49.82

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.31

0.31

2.7

2.6

0.53

0.69

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.26

0.30

2.7

2.6

2.99

1.54

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

466

1.14

0.28

2.8

2.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

264

1.17

0.27

1.8

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

312

1.16

0.27

1.9

2.2

—

(3000850) Epithelial cells [#/volume] in Urine

274

1.16

0.26

2.6

2.4

4.16

5.81

e6/l

0.77

239

(3035350) Ketones [Presence] in Urine by Test strip

665

1.12

0.26

3.5

3.6

0.00

0.01

estimate

0.50

136

(1002224) Polysomnography panel

1.26

0.26

1.2

1.1

—

(3015736) pH of Urine

548

1.12

0.25

3.3

3.2

6.00

5.87

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.30

0.25

7.3

6.9

24.96

25.19

mmol/l

—

(4035726) Immunohistochemistry procedure

115

1.24

0.24

1.4

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.27

0.23

2.0

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.29

0.23

2.4

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.29

0.23

1.0

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.24

0.22

4.9

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.20

0.21

2.4

1.7

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

2.5

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.50

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.21

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

347

1.12

0.21

3.2

1778.38

262.70

mg/l

0.41

219

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.08

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.9

—

12.82

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

514

1.11

0.21

3.8

3.6

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.16

0.15

1.1

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.15

0.15

2.6

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

423

1.09

0.15

2.1

2.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

263

0.90

0.14

2.7

2.9

0.74

0.78

ug/l

0.06

153

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

602

1.08

0.14

2.8

2.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

503

1.08

0.14

4.5

3.5

25.61

41.28

ng/l

0.63

319

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

100

0.79

0.14

1.9

2.4

—

17.10

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

354

0.91

0.13

4.2

4.1

26.16

21.68

0.49

160

(3026008) Bacteria identified in Urine by Culture

350

1.07

0.10

3.5

3.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.14

0.09

1.8

44.00

36.51

nmol/l

—

(40761536) Microorganisms panel - Urine sediment

113

0.88

0.08

5.7

3.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.04

0.08

1.7

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

313

1.07

0.08

1.4

1.2

1.44

1.59

u/ml

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.10

0.08

24.1

10.4

—

(3000330) Specific gravity of Urine by Test strip

1.08

0.08

3.4

3.7

—

(3022145) Colonoscopy Study observation

166

1.09

0.08

1.1

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

383

1.06

0.08

3.4

3.3

—

(3008898) HLA-B27 [Presence]

0.84

0.08

1.2

1.1

—

(40768797) Stomach Pathology biopsy report

186

1.09

0.07

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

153

0.91

0.07

1.6

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.86

0.07

2.0

1.3

—

(3022621) pH of Urine by Test strip

0.83

0.07

3.0

2.2

—

(36660697) Celiac disease serology panel - Serum

110

1.10

0.05

1.3

1.1

—

(40761511) CBC panel - Blood by Automated count

143

1419

1.07

0.05

19.0

12.1

—

(3000492) Spirometry study

150

1.07

0.04

1.3

1.5

—

(3016502) Oxygen saturation in Arterial blood

119

0.92

0.04

16.0

9.1

96.83

95.64

0.62

114

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

130

1290

1.04

0.03

3.8

4.0

1.33

1.31

mmol/l

0.10

118

1194

(3000963) Hemoglobin [Mass/volume] in Blood

149

1498

0.93

0.03

28.7

19.9

134.59

137.26

g/l

1.41

149

1477

(3024731) MCV [Entitic volume]

149

1498

0.93

0.03

28.5

19.7

89.74

90.69

1.40

149

1478

(3035941) MCH [Entitic mass]

149

1498

0.93

0.03

28.5

19.7

29.86

30.25

1.46

149

1478

(3019150) Specific gravity of Urine by Refractometry

282

1.03

0.02

3.5

3.6

1.02

kg/l

—

(40768804) Tissue Pathology biopsy report

528

1.01

0.00

2.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

143

0.98

0.00

1.6

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

353

0.99

0.00

2.3

3.0

1569.29

884.60

ng/l

0.43

288

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

927

1.01

0.00

3.5

3.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

185

0.97

0.00

1.3

1.4

—

(3002256) Pathology report gross observation

155

1.04

0.00

1.4

1.2

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.4

—

4.42

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

30.50

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.5

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.7

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.96

-0.00

2.0

1.3

—

(3019060) Gas panel - Arterial blood

0.97

-0.00

10.9

4.7

—

(4200892) Spirometry reversibility

0.93

-0.00

1.1

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

3.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

16.01

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.9

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

8.89

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.02

-0.00

1.6

1.2

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.5

—

8.20

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.89

-0.00

1.4

2.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

2.0

—

84.86

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

2.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.6

—

120.71

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

140

1.00

-0.00

2.7

1.8

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.6

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

5.7

—

223.83

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

116.50

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.8

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.5

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.2

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.6

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

1.7

—

7.43

—

(40761535) Cells panel - Urine sediment

0.93

-0.00

2.3

4.2

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.8

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

41.08

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

222.52

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

116.94

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HEPATITIS_A and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	2.036 [1.4, 2.96]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.506

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 336 females with AB1_HEPATITIS_A died.

Males

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	3.07 [2.26, 4.18]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 473 males with AB1_HEPATITIS_A died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_A.

N-year risk	Females	Males
1	0.231%	0.453%
5	1.239%	3.157%
10	3.161%	7.868%
15	6.288%	14.48%
20	11.069%	23.486%

Relationships between endpoints

↥

Index endpoint: AB1_HEPATITIS_A – Acute hepatitis A

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acute hepatitis A

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints