Acute hepatitis A

AB1_HEPATITIS_A

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B15 Hospital discharge: ICD-9 — 070[0-1] Cause of death: ICD-10 — B15 Cause of death: ICD-9 — 070[0-1] 2 out of 7 registries used, show all original rules.	159
4. Check minimum number of events None	159
5. Include endpoints None	159
6. Filter based on genotype QC (FinnGen only)	159

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: B15-B19
Name in latin: Hepatitis A acuta

NAME	AB1_HEPATITIS_A
CONTROL_EXCLUDE	AB1_VIRAL_HEPATITIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B15
HD_ICD_9	070[0-1]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B15
COD_ICD_9	070[0-1]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute hepatitis A based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1602	688	896
Only index persons	1328	598	730
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	36.85	37.94	35.93
Only index persons	34.38	35.37	33.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	159	81	78
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	38.51	37.34	39.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
150: Matched controls
1502

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B15.9

ICD-10 Finland

Hepatitis A without hepatic coma

+∞

111.9

0701A

ICD-9 Finland

Viral hepatitis A without mention of hepatic coma

+∞

49.8

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

59.5

21.9

B18.2

ICD-10 Finland

Chronic viral hepatitis C

+∞

13.7

0700A

ICD-9 Finland

Viral hepatitis A with hepatic coma

+∞

8.4

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

+∞

7.3

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

17.7

6.8

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.6

6.8

B15.0

ICD-10 Finland

Hepatitis A with hepatic coma

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.41

7.01

1.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

16.73

5.47

1.8

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

682

2.20

5.38

7.7

6.4

11.3

11.0

umol/l

0.12

647

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.73

5.13

1.1

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

12.39

3.79

1.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.62

3.18

3.9

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.75

2.97

4.4

2.5

—

(3032080) INR in Blood by Coagulation assay

487

1.74

2.87

9.5

7.0

1.1

1.2

inr

0.16

151

(3044290) Cell count panel - Cerebral spinal fluid

4.37

2.71

2.3

1.5

—

(3019198) Lymphocytes [#/volume] in Blood

696

1.68

2.59

7.2

6.2

2.1

1.8

e9/l

0.54

625

(3021879) Hepatitis B virus core Ab [Presence] in Serum

124

2.10

2.57

1.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

5.62

2.56

3.8

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

103

2.20

2.55

2.2

2.4

11.7

10.2

g/l

0.63

(40758558) Short blood count panel - Blood

342

1.72

2.49

9.3

7.8

—

(3021589) Normoblasts [#/volume] in Blood

589

1.64

2.41

12.5

9.9

0.0

e9/l

0.50

482

(3013115) Eosinophils [#/volume] in Blood

696

1.63

2.38

7.5

6.5

0.2

e9/l

0.48

623

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

4.75

2.29

1.0

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

176

1.87

2.26

2.0

1.8

1.6

1.4

0.30

158

(3028707) Methadone [Presence] in Urine by Screen method

3.23

2.26

1.8

1.3

—

(3006315) Basophils [#/volume] in Blood

674

1.60

2.23

7.4

6.3

0.0

e9/l

0.59

590

(3015377) Calcium [Moles/volume] in Serum or Plasma

414

1.63

2.20

3.8

3.6

2.4

mmol/l

0.72

361

(3028026) IgM [Mass/volume] in Serum or Plasma

2.15

2.16

1.2

1.7

1.1

g/l

0.00

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

142

1.90

2.08

2.5

1.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

772

1.57

2.04

13.8

10.4

3.9

4.2

e9/l

1.07

684

(3001604) Monocytes [#/volume] in Blood

674

1.56

2.03

7.5

6.2

0.6

e9/l

0.09

587

(3001122) Ferritin [Mass/volume] in Serum or Plasma

569

1.56

2.02

3.0

2.6

92.2

107.3

ug/l

0.41

523

(3026782) Osmolality of Urine

248

1.70

2.01

3.1

2.7

532.8

554.3

mosm/kgh2o

0.19

209

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

144

1.87

2.00

2.6

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.92

0.0

2.0

—

(3037522) Nuclear Ab [Titer] in Serum

187

1.74

1.86

1.2

1.4

320.0

413.3

titre

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

540

1.53

1.85

7.1

4.6

34.9

35.9

g/l

0.85

514

(3037756) Immunofixation for Serum or Plasma

3.13

1.82

1.0

2.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

113

969

1.57

1.81

4.8

4.3

13.1

10.8

mm/h

0.81

106

899

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.28

1.72

2.2

2.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

284

1.60

1.72

2.9

2.0

3.0

3.2

mg/l

0.25

241

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.93

1.52

1.3

1.4

—

(3012544) pH of Venous blood

118

1.79

1.50

2.2

3.7

—

(3034770) Mitochondria Ab [Titer] in Serum

2.45

1.48

1.3

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.19

1.45

1.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

226

1.58

1.44

1.5

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

144

1.70

1.42

3.0

2.0

—

(42870588) Differential panel, method unspecified - Blood

452

1.45

1.38

7.4

5.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.20

1.37

1.1

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.05

1.37

1.8

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

1.33

0.0

1.5

—

(3011288) Drugs identified in Urine by Screen method

2.16

1.32

14.6

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

123

1105

1.50

1.32

26.3

17.0

13.8

13.7

0.31

123

1091

(3027944) Amphetamines [Presence] in Urine

2.01

1.31

1.8

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.01

1.31

1.8

1.2

—

(3027008) Opiates [Presence] in Urine

2.01

1.31

1.8

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.16

1.30

4.1

2.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.35

1.29

1.9

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.36

1.20

1.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.36

1.20

1.0

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

228

1.51

1.18

1.4

1.2

22.2

6.4

u/ml

—

(3016879) Cocaine [Presence] in Urine

1.96

1.15

1.8

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.05

1.14

1.0

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

170

1.56

1.13

2.0

2.2

17.9

22.3

1.39

145

(3000494) Fungus identified in Specimen by Culture

162

1.57

1.12

1.2

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

188

1.53

1.11

2.3

1.7

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

2.00

1.10

1.9

1.5

263.8

258.2

ug/g

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

163

1.56

1.10

3.0

2.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.97

1.04

2.0

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

100

884

1.35

1.04

4.9

4.3

—

(3023368) Bacteria identified in Blood by Culture

315

1.41

1.03

6.7

4.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

124

1.60

1.02

3.9

3.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

209

1.47

1.02

2.7

1.9

—

(3044889) 12 lead EKG panel

101

897

1.35

1.00

4.4

3.7

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

117

1.61

0.99

2.9

1.9

312.8

388.3

nmol/l

1.14

108

(3018418) pH of Serum or Plasma

365

1.37

0.96

2.9

4.3

7.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.77

0.95

1.6

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

347

1.37

0.95

1.6

1.7

1.6

1.4

mmol/l

0.71

288

(3013826) Glucose [Moles/volume] in Serum or Plasma

770

1.32

0.94

5.9

4.7

6.7

mmol/l

0.04

709

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.27

0.94

1.3

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

135

1261

1.47

0.94

4.6

4.4

6.1

5.9

mmol/l

0.67

129

1169

(3005322) IgE [Units/volume] in Serum or Plasma

1.70

0.91

1.2

111.9

183.8

u/ml

0.80

(1761868) Lipid panel - Serum or Plasma

541

0.74

0.90

3.3

2.8

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.86

0.87

1.1

2.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.97

0.85

1.0

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.85

0.80

1.7

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.85

0.80

1.5

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.79

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.79

0.0

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

132

1240

1.38

0.77

23.4

14.3

40.1

40.7

0.42

106

978

(3018095) Leukocytes [#/volume] in Urine

462

1.29

0.77

3.4

3.6

25.4

68.9

e6/l

1.04

315

(3002582) Erythrocytes [#/volume] in Urine

396

1.30

0.76

2.8

2.9

164.3

203.4

e6/l

0.07

291

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

105

957

1.29

0.76

3.8

14.3

14.7

pmol/l

0.66

875

(3007164) IgA [Mass/volume] in Serum or Plasma

295

1.33

0.74

1.4

2.4

g/l

0.06

178

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

139

1320

1.42

0.72

20.2

13.7

23.5

21.4

mg/l

0.27

116

1042

(3038515) Glucose [Moles/volume] in Venous blood

1.95

0.71

3.0

3.9

6.4

7.9

mmol/l

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.95

0.71

1.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.95

0.71

1.0

1.3

—

(36304419) Bacteria [Presence] in Urine

353

1.30

0.71

2.8

2.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

583

1.26

0.69

7.6

7.4

1.2

mmol/l

0.08

493

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

392

1.28

0.69

2.4

2.1

148.1

162.5

u/l

0.17

370

(3030467) Casts [#/volume] in Urine by Automated count

364

1.29

0.68

2.8

0.2

0.4

e6/l

0.61

258

(3004588) Protein electrophoresis panel - Serum or Plasma

1.58

0.67

1.4

3.0

—

(3013512) EKG study

364

0.75

0.67

4.7

4.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

529

1.25

0.64

2.5

2.4

81.6

74.5

nmol/l

0.87

475

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

219

1.34

0.64

2.0

2.5

15.2

0.8

e6/l

0.49

118

(3003694) ABO and Rh group [Type] in Blood

367

1.28

0.64

1.3

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.69

0.62

1.0

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

125

1177

1.29

0.62

4.7

4.6

1.8

1.9

mu/l

0.17

117

1080

(3021440) Promyelocytes/100 leukocytes in Blood

114

1.45

0.61

2.8

4.4

0.0

0.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.61

0.0

1.2

—

(3019225) pH of Specimen

112

0.61

0.60

3.6

5.2

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.60

0.0

3.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

240

1.31

0.60

4.0

3.5

29.7

216.2

ng/l

1.64

184

(3017181) Myelocytes/100 leukocytes in Blood

124

1.42

0.58

2.8

4.3

0.4

0.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

287

1.28

0.58

2.9

3.6

—

(3042936) Bacteria identified in Isolate by Culture

196

1.33

0.57

1.8

1.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

147

1420

1.47

0.57

14.4

10.6

30.0

27.2

u/l

0.89

142

1380

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

500

1.22

0.53

2.2

1.9

104.8

97.0

pmol/l

0.67

258

(3021601) Nitrite [Presence] in Urine by Test strip

657

1.21

0.52

4.9

5.0

0.0

estimate

0.00

125

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

139

1336

1.32

0.50

4.6

4.8

2.8

mmol/l

0.05

127

1244

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

128

1219

1.26

0.50

6.1

5.6

39.7

39.8

mmol/mol

0.04

123

1145

(3000991) Gas panel - Venous blood

102

1.41

0.49

8.0

9.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

141

0.69

0.47

1.5

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

333

1.23

0.47

3.4

3.9

0.0

estimate

0.50

121

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

204

1.27

0.44

2.2

2.7

8.0

2.3

e6/l

0.42

105

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

139

0.70

0.44

8.0

7.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

131

1257

1.24

0.43

15.0

12.5

86.5

84.3

ml/min/173m2

0.60

115

1037

(3020564) Creatinine [Moles/volume] in Serum or Plasma

144

1397

1.33

0.42

21.1

15.7

73.8

77.3

umol/l

1.26

144

1397

(46235355) HIV 1 and 2 tests - Meaningful Use set

271

1.23

0.41

2.3

2.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.2

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

1.5

—

21.9

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

3.8

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.49

0.40

1.8

4.0

—

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

142

1.30

0.40

1.9

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.33

0.40

11.9

12.4

24.6

24.7

mmol/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

235

1.23

0.39

1.4

1.3

32.9

36.5

iu/ml

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.39

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.39

0.0

2.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

136

1314

1.24

0.38

4.1

4.4

4.7

mmol/l

0.13

124

1231

(21494755) Public health laboratory ask at order entry panel

179

0.76

0.38

1.6

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

275

1.20

0.36

1.7

1.8

0.6

1.2

mg/l

1.68

220

(3052851) Hemolysis interference index of Serum or Plasma

1.48

0.36

1.0

3.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

458

1.17

0.36

2.9

3.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.45

0.36

1.2

1.3

—

(4034850)

1.41

0.35

3.7

8.5

—

(3009261) Glucose [Presence] in Urine by Test strip

667

1.15

0.33

3.4

3.6

0.0

estimate

0.00

120

(3000850) Epithelial cells [#/volume] in Urine

269

1.19

0.32

2.6

2.4

4.2

5.8

e6/l

0.76

228

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

308

1.17

0.31

1.9

2.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

366

1.16

0.31

3.6

4.0

7.2

11.3

mg/mmol

0.40

233

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

135

1310

1.20

0.31

4.0

4.4

1.4

mmol/l

0.42

125

1217

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.36

0.31

1.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.31

0.31

3.7

3.8

48.1

49.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.26

0.30

2.7

2.6

3.0

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

652

1.13

0.29

3.4

3.6

0.0

estimate

0.00

128

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.34

0.29

7.3

7.0

25.0

25.3

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

507

1.13

0.26

3.8

3.7

—

(1002224) Polysomnography panel

1.26

0.26

1.2

1.1

—

(4035726)

114

1.25

0.26

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.33

0.23

2.4

1.7

—

(3027801) Oxygen [Partial pressure] in Arterial blood

125

1.22

0.23

12.1

8.9

13.5

12.0

kpa

0.35

120

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

125

1.22

0.23

12.1

9.0

5.3

5.1

kpa

0.42

119

(3025941) Bacteria identified in Stool by Culture

1.27

0.23

2.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.29

0.23

2.2

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.29

0.23

1.0

1.2

—

(3020891) Body temperature

1.26

0.22

2.2

4.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.23

0.22

2.4

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

592

1.11

0.21

4.4

4.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.21

0.0

2.5

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.1

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.9

—

12.8

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.23

0.20

4.9

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

418

1.11

0.19

2.1

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

263

1.13

0.18

1.8

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.15

0.18

24.1

10.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.16

0.15

2.6

1.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.16

0.15

1.1

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

346

0.91

0.15

4.2

4.1

26.2

21.5

0.51

157

(3012516) Albumin [Mass/volume] in Urine

344

1.10

0.15

3.0

3.3

1846.2

264.8

mg/l

0.41

217

(4010399)

0.82

0.15

1.1

1.6

—

(3016502) Oxygen saturation in Arterial blood

117

0.84

0.13

17.5

9.2

96.6

95.6

—

112

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

495

1.08

0.12

4.6

3.5

26.2

35.6

ng/l

0.36

311

(3041096) Erythrocytes [Presence] in Urine by Automated

378

1.08

0.11

3.4

3.3

—

(3000492) Spirometry study

145

1.12

0.09

1.3

1.5

—

(40768797) Stomach Pathology biopsy report

184

1.10

0.09

1.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.14

0.09

1.8

44.0

36.5

nmol/l

—

(3026008) Bacteria identified in Urine by Culture

342

1.07

0.09

3.6

3.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.05

0.08

1.7

1.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

256

0.93

0.08

2.7

2.9

0.7

0.8

ug/l

0.07

148

(3000330) Specific gravity of Urine by Test strip

1.08

0.08

3.4

3.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.03

0.08

1.6

1.2

—

(3008898) HLA-B27 [Presence]

0.84

0.08

1.2

1.1

—

(3019060) Gas panel - Arterial blood

0.84

0.08

12.5

4.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.86

0.07

2.0

1.3

—

(3022621) pH of Urine by Test strip

0.84

0.07

3.0

2.2

—

(40761536) Microorganisms panel - Urine sediment

111

0.89

0.06

5.7

3.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

151

0.92

0.05

1.6

1.5

—

(36660697) Celiac disease serology panel - Serum

110

1.10

0.05

1.3

1.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

350

0.96

0.03

2.3

3.0

1619.3

868.0

ng/l

0.46

286

(40761511) CBC panel - Blood by Automated count

141

1401

1.06

0.03

19.2

12.2

—

(3035941) MCH [Entitic mass]

147

1478

0.93

0.03

28.7

19.8

29.8

30.2

1.53

147

1458

(3024731) MCV [Entitic volume]

147

1478

0.93

0.03

28.6

19.8

89.7

90.7

1.48

147

1458

(3000963) Hemoglobin [Mass/volume] in Blood

147

1478

0.93

0.03

28.8

20.0

134.3

137.2

g/l

1.58

147

1457

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

128

1271

1.04

0.02

3.8

4.0

1.3

mmol/l

0.10

116

1176

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

312

1.03

0.02

1.4

1.2

1.6

u/ml

—

(3019832) Treponema pallidum Ab [Presence] in Serum

139

1.01

0.00

2.7

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

141

0.99

0.00

1.6

1.5

—

(3019150) Specific gravity of Urine by Refractometry

279

1.00

0.00

3.6

1.0

kg/l

—

(40768804) Tissue Pathology biopsy report

523

0.99

0.00

2.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

915

1.01

0.00

3.6

3.4

—

(3022145) Colonoscopy Study observation

165

1.03

0.00

1.1

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

185

0.97

0.00

1.3

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

135

1.04

0.00

19.9

22.4

—

1.4

—

(3002256) Pathology report gross observation

155

1.04

0.00

1.4

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.6

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.7

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

116.5

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.7

—

223.8

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

3.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(40761535) Cells panel - Urine sediment

0.94

0.00

2.3

4.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.5

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

30.5

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

116.9

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

8.9

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.96

0.00

2.0

1.3

—

(4211845)

0.00

0.0

1.6

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.91

0.00

14.3

7.8

25.0

24.6

mmol/l

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

2.6

—

120.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

310

1.00

0.00

5.6

5.3

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.6

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

2.0

—

84.9

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

0.0

4.4

—

4.4

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

1.9

—

16.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.8

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.89

0.00

1.4

2.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(4027681)

0.00

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HEPATITIS_A and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	2.036 [1.4, 2.96]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.506

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 336 females with AB1_HEPATITIS_A died.

Males

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_A	3.07 [2.26, 4.18]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 473 males with AB1_HEPATITIS_A died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_A.

N-year risk	Females	Males
1	0.231%	0.453%
5	1.239%	3.157%
10	3.161%	7.868%
15	6.288%	14.48%
20	11.069%	23.486%

Relationships between endpoints

↥

Index endpoint: AB1_HEPATITIS_A – Acute hepatitis A

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acute hepatitis A

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints