No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
203 |
Control definitions (FinnGen only)
- Control exclude
- AB1_PROTOZOAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Toxoplasmosis
based on the number of shared cases.
Similar with more cases:
- Protozoal diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1599 | 935 | 652 |
| Only index persons | 1392 | 844 | 548 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 31.42 | 32.08 | 30.30 |
| Only index persons | 30.26 | 31.16 | 28.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 203 | 131 | 72 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 33.49 | 32.08 | 36.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 185
- Matched controls
- 1848
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H32.0*B58.0
ICD-10 Finland
Toxoplasma chorioretinitis
+∞
64.4
58
*
B58.9
ICD-10 Finland
Toxoplasmosis, unspecified
+∞
28.9
27
*
13000
ICD-8 Finland
Toxoplasmosis, Acquired
+∞
26.7
25
*
B58.0
ICD-10 Finland
Toxoplasma oculopathy
+∞
22.3
21
*
1302A
ICD-9 Finland
Toxoplasmosis, Chorioretinitis due to toxoplasmosis
+∞
18.0
17
*
13099
ICD-8 Finland
Toxoplasmosis, Unspecified
+∞
16.9
16
*
H32.0
ICD-10 Finland
Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
185.9
16.8
17
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
54.0
13.0
15
*
1309X
ICD-9 Finland
Toxoplasmosis, unspecified
+∞
10.5
10
*
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
10.5
10
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
13.2
10.1
17
14
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
9.4
9
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
7.4
8.3
19
28
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
7.6
43
162
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
7.0
30
91
H30.2
ICD-10 Finland
Posterior cyclitis
72.2
6.5
7
*
H02AB07
ATC
prednisone; oral
3.0
6.4
39
152
S01FA02
ATC
scopolamine; ophthalmic
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
42
3.78
4.86
1.4
1.5
0.0
0.1
iu/ml
—
5
6
8
9
9.19
4.32
2.6
1.2
1311.1
879.0
u/ml
—
8
9
7
7
10.30
4.04
3.3
1.3
—
—
—
0
0
42
230
2.04
3.80
3.3
2.2
12.6
13.9
umol/l
0.48
36
211
11
30
3.82
3.69
1.0
1.2
—
—
—
0
0
125
969
1.75
3.65
13.0
9.4
4.1
4.1
e9/l
0.04
110
847
65
418
1.82
3.63
2.5
2.6
362.0
6205.6
umol/l
2.02
58
364
37
209
1.94
3.05
3.6
2.2
2.3
2.4
g/l
0.82
32
192
35
198
1.93
2.87
3.8
2.2
21.9
22.8
%
0.13
27
170
21
102
2.18
2.58
2.9
1.5
—
—
—
0
0
5
7
7.29
2.56
13.6
2.4
—
—
—
0
0
5
7
7.29
2.56
13.6
2.4
—
—
—
0
0
5
7
7.29
2.56
1.2
1.3
12.6
14.6
u/l
—
5
7
13
51
2.66
2.49
1.1
2.5
—
—
—
0
0
10
34
3.04
2.45
1.6
1.4
—
—
—
0
0
13
52
2.60
2.41
2.2
2.3
—
—
—
0
0
7
18
3.99
2.27
1.0
1.1
—
—
—
0
0
96
753
1.52
2.26
8.5
6.5
1.2
1.2
mmol/l
0.74
76
632
38
240
1.72
2.19
2.7
1.8
—
—
—
0
0
7
19
3.78
2.17
1.0
1.2
—
—
—
0
0
0
55
0.00
2.10
0.0
1.6
—
—
—
0
0
7
20
3.59
2.07
1.0
1.2
—
—
—
0
0
89
698
1.49
2.05
7.4
5.6
1.2
1.2
mmol/l
1.12
79
635
5
11
4.63
1.95
11.4
4.7
—
—
—
0
0
144
1253
1.51
1.92
5.0
3.9
14.2
10.9
mm/h
1.49
135
1148
5
12
4.24
1.83
1.6
2.6
—
—
—
0
0
9
35
2.64
1.82
9.2
1.8
—
—
—
0
0
5
13
3.91
1.72
1.8
1.3
—
—
—
0
0
18
98
1.92
1.68
1.1
1.0
—
—
—
0
0
8
32
2.56
1.61
1.4
1.3
—
—
—
0
0
50
368
1.48
1.52
2.0
1.8
1.0
1.1
mg/l
0.19
37
292
6
21
2.91
1.51
1.5
1.8
—
—
—
0
0
147
1312
1.44
1.49
9.7
7.0
80.7
76.4
u/l
0.56
141
1223
11
54
2.10
1.35
2.3
1.8
—
—
—
0
0
0
39
0.00
1.35
0.0
1.5
—
—
—
0
0
190
1803
1.84
1.32
21.3
14.5
77.5
74.3
umol/l
0.69
190
1803
5
18
2.82
1.29
3.2
3.7
—
—
—
0
0
183
1722
1.64
1.28
19.6
12.5
24.2
20.7
mg/l
0.56
148
1335
6
26
2.35
1.19
1.0
1.1
—
—
—
0
0
57
451
1.37
1.15
4.1
2.8
0.4
0.4
e6/l
0.04
43
341
7
31
2.30
1.11
2.0
1.4
—
—
—
0
0
7
32
2.23
1.09
1.3
1.5
—
—
—
0
0
7
32
2.23
1.09
1.3
1.5
—
—
—
0
0
25
171
1.53
1.09
2.6
1.7
—
—
—
0
0
23
155
1.55
1.07
6.1
7.8
0.6
1.4
mmol/l
0.58
16
117
11
60
1.88
1.05
3.6
1.8
—
—
—
0
0
70
580
1.32
1.04
4.1
2.9
—
—
—
0
0
50
394
1.36
1.04
1.2
1.3
1.2
1.2
u/ml
—
7
122
41
314
1.38
1.01
1.2
1.2
22.6
26.5
iu/ml
0.17
12
112
24
166
1.51
1.00
2.5
1.7
—
—
—
0
0
5
23
2.20
0.98
1.2
1.0
—
—
—
0
0
47
371
1.35
0.96
2.5
1.9
2.7
3.0
mg/l
0.38
40
317
80
681
1.29
0.96
6.0
4.5
34.9
36.1
g/l
0.91
74
642
0
32
0.00
0.96
0.0
1.7
—
—
—
0
0
9
51
1.80
0.96
1.9
1.2
—
—
—
0
0
19
126
1.56
0.95
1.1
1.2
228.7
101.7
iu/ml
—
8
46
7
37
1.92
0.95
2.0
1.6
—
—
—
0
0
7
37
1.92
0.95
2.0
1.5
—
—
—
0
0
5
105
0.46
0.91
1.8
1.6
—
—
—
0
0
37
284
1.37
0.90
4.0
3.2
254.4
192.5
ng/l
0.11
28
216
13
79
1.69
0.90
2.5
1.7
—
—
—
0
0
143
1317
1.29
0.88
4.3
4.1
14.7
14.7
pmol/l
0.00
131
1209
173
1638
1.38
0.86
4.4
4.4
5.9
5.9
mmol/l
0.07
161
1516
80
690
1.26
0.85
2.4
2.4
75.7
76.5
nmol/l
0.08
71
620
6
32
1.90
0.82
1.3
1.5
—
—
—
0
0
6
32
1.90
0.82
1.2
1.3
—
—
—
0
0
44
353
1.31
0.81
1.5
1.6
—
—
—
0
0
94
830
1.25
0.81
4.5
3.5
0.0
0.0
estimate
0.00
13
172
94
832
1.24
0.79
5.9
4.8
0.0
0.0
estimate
0.00
13
170
10
59
1.73
0.77
3.0
1.9
—
—
—
0
0
95
844
1.24
0.76
4.5
3.5
0.0
0.0
estimate
0.00
13
164
168
1592
1.32
0.75
22.9
13.8
40.2
40.4
%
0.12
127
1234
5
24
2.11
0.75
1.2
1.4
—
—
—
0
0
12
181
0.64
0.73
1.3
1.6
—
—
—
0
0
14
93
1.54
0.71
1.4
1.9
—
—
—
0
0
5
29
1.74
0.64
2.4
1.6
—
—
—
0
0
6
36
1.69
0.57
1.8
1.4
—
—
—
0
0
44
373
1.23
0.54
2.9
2.1
—
—
—
0
0
17
127
1.37
0.51
2.2
2.2
68.8
70.5
ml/min/173m2
—
6
49
164
1571
1.23
0.51
5.1
4.8
1.8
1.8
mu/l
0.06
149
1448
16
120
1.36
0.48
1.6
1.9
—
—
—
0
0
5
32
1.58
0.42
1.2
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
455.8
—
0
8
0
15
0.00
0.41
0.0
1.1
—
37.3
—
0
8
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
168
1624
1.20
0.40
3.9
3.8
1.3
1.3
mmol/l
0.27
154
1496
174
1688
1.22
0.39
4.2
4.2
1.5
1.5
mmol/l
0.17
160
1566
166
1605
1.19
0.38
19.1
11.9
83.1
84.0
ml/min/173m2
0.20
144
1303
30
254
1.21
0.38
3.6
2.6
1.1
1.1
e6/l
0.03
16
141
21
171
1.25
0.37
1.5
4.2
2.2
33.5
ug/l
0.71
14
146
54
485
1.15
0.36
1.7
1.6
1.5
1.4
mmol/l
0.38
43
410
65
593
1.14
0.35
3.5
3.4
24.4
26.8
ng/l
0.16
35
375
34
296
1.18
0.33
1.7
1.4
—
—
—
0
0
174
1695
1.19
0.32
4.3
4.3
4.6
4.8
mmol/l
0.71
163
1583
44
393
1.15
0.32
3.5
4.4
1.3
1.8
ug/l
1.77
39
356
67
618
1.13
0.30
2.2
2.0
106.2
96.1
pmol/l
0.80
35
318
176
1719
1.18
0.29
4.7
4.7
2.7
2.8
mmol/l
0.87
162
1594
27
233
1.18
0.29
3.8
2.8
1.8
2.1
e6/l
0.20
13
122
19
158
1.22
0.29
4.7
1.9
349.9
385.8
nmol/l
0.39
19
142
58
532
1.13
0.28
3.4
3.6
2.4
2.4
mmol/l
0.48
52
469
8
62
1.30
0.28
1.4
1.4
—
—
—
0
0
8
67
1.20
0.26
1.3
1.4
202.3
284.1
mu/l
—
8
62
48
522
0.89
0.24
2.9
2.4
57.9
55.0
u/l
0.31
41
483
5
39
1.29
0.23
1.4
1.5
—
—
—
0
0
5
41
1.22
0.22
1.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
12
99
1.23
0.20
1.3
1.4
—
—
—
0
0
6
53
1.14
0.19
2.2
2.0
—
—
—
0
0
20
176
1.15
0.18
6.7
7.0
104.6
104.0
mmol/l
0.49
20
170
31
282
1.12
0.18
2.9
2.8
2.4
2.5
mmol/l
0.57
26
252
7
61
1.15
0.17
2.3
1.5
—
—
—
0
0
5
67
0.74
0.17
1.8
1.5
—
—
—
0
0
69
656
1.08
0.17
4.8
3.6
—
—
—
0
0
121
1176
1.07
0.16
3.5
3.3
—
—
—
0
0
21
230
0.90
0.12
1.7
2.1
—
—
—
0
0
41
431
0.94
0.10
3.3
3.0
1426.5
1018.4
ng/l
0.56
35
355
5
47
1.07
0.09
1.4
1.1
—
—
—
0
0
6
55
1.09
0.09
1.5
1.1
—
—
—
0
0
6
56
1.07
0.08
1.5
1.1
—
—
—
0
0
22
205
1.08
0.08
1.5
1.9
—
—
—
0
0
9
87
1.04
0.07
1.4
1.4
—
—
—
0
0
33
319
1.04
0.04
3.1
4.2
27.8
21.7
%
0.59
13
138
23
240
0.95
0.03
2.3
2.7
0.5
0.8
ug/l
1.57
16
141
79
778
1.03
0.03
4.8
4.0
—
—
—
0
0
76
750
1.02
0.02
3.8
2.6
136.1
105.3
ug/l
0.70
68
700
16
167
0.95
0.01
4.4
3.4
—
—
—
0
0
18
179
1.01
0.00
8.7
6.7
—
—
—
0
0
45
454
0.99
0.00
5.9
3.7
0.0
0.0
estimate
0.00
12
169
25
249
1.00
0.00
1.4
1.7
1.4
1.4
%
0.02
20
218
27
271
1.00
0.00
2.3
1.7
1173.0
1185.3
nmol/l
0.03
18
205
31
307
1.01
0.00
1.2
1.2
7.7
10.1
u/ml
0.13
12
127
158
1575
1.01
0.00
5.0
5.3
39.1
39.4
mmol/mol
0.20
147
1481
60
595
1.01
0.00
5.2
3.2
31.5
32.0
u/l
0.05
55
569
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
111.7
—
0
6
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
7.1
—
0
6
0
6
0.00
0.00
0.0
1.0
—
8.1
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
67.4
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TOXOPLASMOSIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TOXOPLASMOSIS | 2.45 [1.73, 3.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 345 males with AB1_TOXOPLASMOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TOXOPLASMOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.459% |
| 5 | No data | 2.845% |
| 10 | No data | 7.235% |
| 15 | No data | 13.855% |
| 20 | No data | 23.599% |
Relationships between endpoints
↥Index endpoint: AB1_TOXOPLASMOSIS – Toxoplasmosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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