No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
205 |
4. Check minimum number of eventsNone |
205 |
5. Include endpointsNone |
205 |
6. Filter based on genotype QC (FinnGen only) |
201 |
Control definitions (FinnGen only)
- Control exclude
- AB1_PROTOZOAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Toxoplasmosis
based on the number of shared cases.
Similar with more cases:
- Protozoal diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1599 | 935 | 652 |
| Only index persons | 1392 | 844 | 548 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 31.42 | 32.08 | 30.30 |
| Only index persons | 30.26 | 31.16 | 28.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 201 | 129 | 72 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 34.11 | 32.08 | 37.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 205
- Matched controls
- 2050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H32.0*B58.0
ICD-10 Finland
Toxoplasma chorioretinitis
+∞
72.2
65
*
B58.9
ICD-10 Finland
Toxoplasmosis, unspecified
+∞
31.0
29
*
13000
ICD-8 Finland
Toxoplasmosis, Acquired
+∞
29.9
28
*
B58.0
ICD-10 Finland
Toxoplasma oculopathy
+∞
26.6
25
*
1302A
ICD-9 Finland
Toxoplasmosis, Chorioretinitis due to toxoplasmosis
+∞
19.0
18
*
13099
ICD-8 Finland
Toxoplasmosis, Unspecified
+∞
19.0
18
*
H32.0
ICD-10 Finland
Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
+∞
16.9
16
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
7.1
14.4
23
36
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
12.6
12
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.5
11.3
16
8
1309X
ICD-9 Finland
Toxoplasmosis, unspecified
+∞
10.5
10
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
9.8
54
221
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.3
9.5
20
41
S01BA04
ATC
prednisolone; ophthalmic
10.3
9.5
18
19
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
9.4
33
102
H02AB07
ATC
prednisone; oral
3.2
9.2
43
159
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
93.8
8.5
9
*
H30.2
ICD-10 Finland
Posterior cyclitis
83.0
7.5
8
*
13020
ICD-8 Finland
Toxoplasmosis, Late effects of intra-utrine infection
+∞
7.3
7
*
J01FF01
ATC
clindamycin; systemic
2.3
7.3
71
378
36504
ICD-8 Finland
Choroiditis, Retinis, Retino-chorioiditis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
42
3.77
4.86
1.4
1.5
0.02
0.11
iu/ml
—
5
6
8
9
9.19
4.32
2.6
1.2
1311.13
879.00
u/ml
—
8
9
7
7
10.30
4.04
3.3
1.3
—
—
—
0
0
42
233
2.01
3.66
3.3
2.2
12.60
13.76
umol/l
0.43
36
217
126
978
1.75
3.64
13.0
9.3
4.07
4.13
e9/l
0.08
111
855
65
421
1.80
3.53
2.5
2.6
361.76
6111.77
umol/l
2.02
58
370
11
30
3.81
3.13
1.0
1.2
—
—
—
0
0
37
212
1.91
2.92
3.6
2.2
2.30
2.42
g/l
0.80
32
195
35
202
1.88
2.70
3.8
2.2
21.95
22.77
%
0.12
27
173
21
102
2.18
2.58
2.9
1.5
—
—
—
0
0
5
7
7.28
2.56
1.2
1.3
12.60
14.57
u/l
—
5
7
5
7
7.28
2.56
13.6
2.4
—
—
—
0
0
5
7
7.28
2.56
13.6
2.4
—
—
—
0
0
13
51
2.65
2.49
1.1
2.5
—
—
—
0
0
13
51
2.65
2.49
2.2
2.3
—
—
—
0
0
39
240
1.77
2.46
2.7
1.8
—
—
—
0
0
98
763
1.54
2.43
8.4
6.5
1.21
1.22
mmol/l
0.90
78
645
10
34
3.04
2.31
1.6
1.4
—
—
—
0
0
7
18
3.99
2.27
1.0
1.1
—
—
—
0
0
7
19
3.78
2.17
1.0
1.2
—
—
—
0
0
0
55
0.00
2.10
0.0
1.6
—
—
—
0
0
7
20
3.59
2.07
1.0
1.2
—
—
—
0
0
90
707
1.49
2.05
7.4
5.5
1.21
1.22
mmol/l
1.20
80
647
146
1268
1.53
1.99
5.0
3.9
14.15
10.86
mm/h
1.48
137
1163
5
11
4.63
1.95
11.4
4.4
—
—
—
0
0
5
12
4.24
1.83
1.6
2.6
—
—
—
0
0
5
12
4.24
1.83
1.6
1.3
—
—
—
0
0
9
35
2.64
1.82
9.2
1.9
—
—
—
0
0
18
99
1.90
1.63
1.1
1.0
—
—
—
0
0
8
32
2.56
1.61
1.4
1.3
—
—
—
0
0
6
21
2.91
1.51
1.5
1.8
—
—
—
0
0
148
1326
1.42
1.42
9.7
7.0
80.59
76.33
u/l
0.57
142
1238
50
375
1.44
1.38
2.0
1.8
0.99
1.12
mg/l
0.21
37
297
5
17
2.99
1.36
1.4
1.5
—
—
—
0
0
5
17
2.99
1.36
1.4
1.5
—
—
—
0
0
12
61
2.03
1.36
3.3
1.7
—
—
—
0
0
192
1821
1.86
1.35
21.4
14.5
77.64
74.33
umol/l
0.71
192
1821
0
39
0.00
1.35
0.0
1.5
—
—
—
0
0
26
170
1.61
1.34
2.5
1.7
—
—
—
0
0
11
55
2.06
1.30
2.3
1.8
—
—
—
0
0
185
1741
1.64
1.29
19.6
12.5
23.99
20.74
mg/l
0.52
150
1352
5
18
2.82
1.29
3.2
3.7
—
—
—
0
0
24
156
1.61
1.27
6.1
7.7
0.66
1.44
mmol/l
0.61
17
121
6
25
2.44
1.25
2.7
2.2
21.15
25.08
mmol/l
—
6
25
25
165
1.59
1.25
2.5
1.7
—
—
—
0
0
58
455
1.38
1.24
4.2
2.8
0.37
0.39
e6/l
0.04
45
345
6
26
2.35
1.19
1.7
1.6
—
—
—
0
0
6
26
2.35
1.19
1.0
1.1
—
—
—
0
0
6
26
2.35
1.19
1.7
1.6
—
—
—
0
0
5
20
2.54
1.16
2.2
1.9
—
—
—
0
0
7
31
2.30
1.11
2.0
1.4
—
—
—
0
0
71
585
1.33
1.10
4.1
2.9
—
—
—
0
0
7
32
2.23
1.09
1.3
1.5
—
—
—
0
0
7
32
2.23
1.09
1.3
1.5
—
—
—
0
0
46
355
1.38
1.08
1.5
1.6
—
—
—
0
0
48
374
1.37
1.06
2.5
1.9
2.75
3.01
mg/l
0.36
41
320
5
23
2.20
0.98
1.2
1.0
—
—
—
0
0
81
689
1.29
0.98
6.0
4.5
34.89
36.18
g/l
0.98
75
653
9
50
1.84
0.98
1.9
1.2
—
—
—
0
0
0
32
0.00
0.96
0.0
1.7
—
—
—
0
0
41
317
1.37
0.96
1.2
1.2
22.57
26.32
iu/ml
0.16
12
113
19
126
1.56
0.95
1.1
1.2
228.68
101.71
iu/ml
—
8
46
7
37
1.92
0.95
2.0
1.6
—
—
—
0
0
7
37
1.92
0.95
2.0
1.5
—
—
—
0
0
145
1332
1.30
0.94
4.2
4.0
14.75
14.73
pmol/l
0.02
133
1220
5
103
0.47
0.92
1.8
1.6
—
—
—
0
0
50
402
1.32
0.91
1.2
1.2
1.21
1.17
u/ml
—
7
123
13
79
1.69
0.90
2.5
1.6
—
—
—
0
0
175
1656
1.39
0.88
4.4
4.4
5.85
5.87
mmol/l
0.10
163
1534
37
287
1.35
0.85
4.0
3.1
254.43
189.90
ng/l
0.11
28
219
6
31
1.96
0.85
1.3
1.5
—
—
—
0
0
6
32
1.90
0.82
1.2
1.3
—
—
—
0
0
8
47
1.73
0.81
2.8
1.9
145.13
319.90
ug/l
—
8
42
95
842
1.24
0.78
5.9
4.8
0.00
0.00
estimate
-0.00
13
173
80
696
1.25
0.78
2.4
2.4
75.71
76.61
nmol/l
0.10
71
626
12
183
0.63
0.76
1.3
1.6
—
—
—
0
0
95
844
1.23
0.76
4.5
3.5
0.00
0.00
estimate
-0.00
14
184
96
854
1.23
0.76
4.5
3.5
0.00
0.00
estimate
-0.00
13
167
10
60
1.70
0.73
3.0
1.9
—
—
—
0
0
5
25
2.02
0.73
1.2
1.4
—
—
—
0
0
14
95
1.51
0.66
1.4
1.9
—
—
—
0
0
5
29
1.74
0.64
2.4
1.6
—
—
—
0
0
45
375
1.26
0.63
2.8
2.1
—
—
—
0
0
5
30
1.68
0.62
4.4
2.8
60.60
61.43
%
—
5
30
6
36
1.69
0.57
1.8
1.4
—
—
—
0
0
197
1927
1.57
0.56
27.4
18.7
40.18
40.50
%
0.30
183
1823
166
1588
1.24
0.54
5.1
4.8
1.85
1.84
mu/l
0.04
151
1465
9
63
1.45
0.53
1.3
1.4
—
—
—
0
0
17
127
1.37
0.51
2.2
2.1
68.83
70.53
ml/min/173m2
—
6
49
31
256
1.25
0.48
3.6
2.6
1.23
1.07
e6/l
0.16
17
143
170
1642
1.21
0.42
4.0
3.8
1.34
1.30
mmol/l
0.26
156
1514
16
123
1.33
0.42
1.6
1.9
—
—
—
0
0
176
1706
1.22
0.41
4.3
4.2
1.46
1.48
mmol/l
0.21
162
1586
5
33
1.53
0.41
1.2
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
455.75
—
0
8
0
15
0.00
0.41
0.0
1.0
—
37.25
—
0
8
35
300
1.20
0.39
1.7
1.4
—
—
—
0
0
53
473
1.16
0.38
4.1
3.5
27.20
8.45
mg/mmol
0.80
32
290
168
1626
1.18
0.37
19.0
11.9
82.96
84.09
ml/min/173m2
0.26
146
1326
66
600
1.15
0.37
3.7
3.5
24.35
26.99
ng/l
0.20
36
380
21
172
1.25
0.36
1.5
4.2
2.20
33.43
ug/l
0.71
14
146
176
1713
1.19
0.34
4.4
4.3
4.62
4.75
mmol/l
0.81
165
1603
13
100
1.32
0.34
1.3
1.4
—
—
—
0
0
68
624
1.13
0.33
2.3
2.0
105.46
96.03
pmol/l
0.75
36
322
45
402
1.15
0.32
3.5
4.4
1.33
1.84
ug/l
1.84
40
364
178
1737
1.19
0.31
4.8
4.7
2.71
2.83
mmol/l
0.94
164
1614
54
491
1.14
0.30
1.7
1.6
1.54
1.40
mmol/l
0.40
43
415
7
56
1.26
0.29
1.4
1.1
—
—
—
0
0
19
158
1.22
0.29
4.7
1.9
349.89
385.75
nmol/l
0.39
19
142
7
57
1.24
0.29
1.4
1.1
—
—
—
0
0
27
234
1.18
0.28
3.8
2.8
1.77
2.14
e6/l
0.20
13
123
21
178
1.20
0.27
6.7
7.0
104.76
104.12
mmol/l
0.52
21
178
8
67
1.20
0.26
1.3
1.4
202.27
284.13
mu/l
—
8
62
32
285
1.15
0.24
2.8
2.8
2.43
2.45
mmol/l
0.68
27
255
58
538
1.11
0.24
3.4
3.5
2.37
2.36
mmol/l
0.45
52
477
5
39
1.29
0.23
1.4
1.5
—
—
—
0
0
123
1186
1.09
0.22
3.6
3.3
—
—
—
0
0
5
41
1.22
0.22
1.2
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
—
—
0
0
49
528
0.91
0.21
2.9
2.4
58.05
56.04
u/l
0.20
42
490
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
76
722
1.08
0.19
19.4
11.3
1.16
1.21
inr
0.21
25
211
6
53
1.14
0.19
2.2
2.0
—
—
—
0
0
70
664
1.08
0.18
4.8
3.6
—
—
—
0
0
7
61
1.15
0.17
2.3
1.5
—
—
—
0
0
5
68
0.73
0.17
1.8
1.5
—
—
—
0
0
23
208
1.12
0.14
1.5
1.9
—
—
—
0
0
81
783
1.06
0.11
3.3
2.5
—
—
—
0
0
5
47
1.07
0.09
1.4
1.1
—
—
—
0
0
42
440
0.94
0.09
3.3
3.0
1423.97
1010.98
ng/l
0.59
36
362
78
759
1.04
0.08
3.8
2.6
134.65
104.02
ug/l
0.72
70
709
9
88
1.02
0.07
1.4
1.4
—
—
—
0
0
22
233
0.94
0.06
1.7
2.1
—
—
—
0
0
34
326
1.05
0.06
3.1
4.2
27.45
21.47
%
0.63
14
142
16
169
0.94
0.03
4.4
3.4
—
—
—
0
0
19
181
1.05
0.03
8.4
6.8
—
—
—
0
0
160
1592
1.02
0.01
5.0
5.3
39.04
39.40
mmol/mol
0.23
149
1498
61
602
1.02
0.01
5.1
3.2
31.36
31.81
u/l
0.05
56
576
24
244
0.98
0.00
2.2
2.7
0.44
0.76
ug/l
1.73
17
145
31
311
1.00
0.00
1.2
1.2
7.70
9.99
u/ml
0.12
12
128
28
275
1.02
0.00
2.2
1.7
1194.35
1193.96
nmol/l
0.00
19
209
46
462
0.99
0.00
5.9
3.7
0.00
0.00
estimate
-0.00
12
173
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
25
250
1.00
-0.00
1.4
1.7
1.37
1.38
%
0.01
20
219
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
8.12
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
111.67
—
0
6
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
7.13
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
67.44
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TOXOPLASMOSIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TOXOPLASMOSIS | 2.45 [1.73, 3.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 345 males with AB1_TOXOPLASMOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TOXOPLASMOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.459% |
| 5 | No data | 2.845% |
| 10 | No data | 7.235% |
| 15 | No data | 13.855% |
| 20 | No data | 23.599% |
Relationships between endpoints
↥Index endpoint: AB1_TOXOPLASMOSIS – Toxoplasmosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data