Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
109 |
4. Check minimum number of eventsNone |
109 |
5. Include endpointsNone |
109 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis factitia
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis factitia
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of the thyroid gland
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 609 | 533 | 72 |
| Only index persons | 568 | 503 | 65 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.00 |
| Only index persons | 0.02 | 0.02 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 61.75 | 61.52 | 63.95 |
| Only index persons | 60.75 | 60.51 | 62.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 101 | 8 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.00 |
| Median age at first event (years) | 56.93 | 55.79 | 71.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
139.9
99
*
H03AA01
ATC
levothyroxine sodium; systemic
57.3
51.7
94
191
104
Kela drug reimbursment
Thyroid insufficiency
15.9
27.1
48
54
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
345.4
27.1
26
*
H03BB01
ATC
carbimazole; oral
69.0
23.4
26
5
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
8.3
19.2
51
110
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
73.7
11.9
13
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
11.6
10.9
20
21
C07AA05
ATC
propranolol; systemic
4.3
9.5
41
137
BAA60
NOMESCO Finland
Total thyroidectomy
22.4
8.7
12
6
R53
ICD-10 Finland
Malaise and fatigue
3.9
8.0
38
136
E03
ICD-10 Finland
Other hypothyroidism
5.9
7.5
21
43
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
11.2
6.7
12
12
N06AB03
ATC
fluoxetine; oral
4.7
6.5
22
56
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
19.5
6.4
9
5
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
48
23.80
61.79
7.0
1.8
4.5
4.4
pmol/l
0.02
51
40
36
88
5.62
14.88
2.3
2.1
335.9
387.4
nmol/l
0.81
31
82
31
75
5.38
12.81
1.2
1.3
282.4
161.5
iu/ml
0.48
13
30
63
321
3.28
8.55
2.6
2.7
2.3
2.4
mmol/l
0.32
58
283
44
185
3.31
8.17
1.8
1.7
454.4
497.3
pmol/l
0.47
35
152
75
440
3.26
7.71
7.6
5.6
1.2
1.2
mmol/l
0.46
58
368
65
358
3.02
7.36
2.3
1.8
96.6
96.1
pmol/l
0.02
38
158
34
147
2.91
5.76
1.7
1.7
1227.0
1195.4
nmol/l
0.08
27
105
41
202
2.65
5.38
2.6
2.0
2.9
3.1
mg/l
0.22
30
169
69
436
2.59
5.37
3.6
2.5
79.7
74.0
ug/l
0.26
64
396
57
335
2.47
5.10
5.7
3.8
17.5
33.4
ng/l
0.68
38
222
47
253
2.51
5.09
3.6
3.1
821.2
932.2
ng/l
0.12
38
208
20
68
3.38
5.03
6.1
3.5
2.5
2.5
mmol/l
0.04
15
52
75
508
2.53
4.81
5.6
4.3
6.9
6.5
mmol/l
0.62
70
463
94
715
3.29
4.73
5.0
3.9
12.0
11.5
mm/h
0.14
89
654
66
427
2.38
4.62
2.6
2.1
80.9
76.5
nmol/l
0.55
58
375
42
223
2.44
4.60
1.5
1.4
16.0
23.0
nmol/l
3.46
37
184
51
296
2.36
4.57
2.6
3.0
29.5
29.3
u/l
0.02
46
283
59
368
2.32
4.44
5.1
3.7
—
—
—
0
0
77
541
2.44
4.35
6.6
8.9
3.6
4.0
e9/l
0.78
69
478
41
222
2.36
4.25
1.6
1.2
0.6
1.2
u/ml
0.96
12
55
100
846
3.20
3.52
8.6
5.1
40.4
39.1
mmol/mol
0.55
90
778
60
403
2.09
3.48
6.3
4.9
1.2
1.2
mmol/l
0.77
53
358
67
471
2.10
3.42
7.2
5.0
0.0
0.0
estimate
0.00
19
87
67
474
2.07
3.33
4.8
3.7
0.0
0.0
estimate
0.00
18
86
37
210
2.15
3.31
1.6
1.8
0.5
1.2
mg/l
2.66
30
170
15
55
3.00
3.31
1.8
1.5
—
—
—
0
0
66
471
2.02
3.12
4.9
3.7
0.0
0.0
estimate
0.00
18
87
5
5
10.39
3.01
2.0
1.2
6.3
10.2
umol/l
—
5
5
102
891
3.25
2.92
6.0
4.3
6.0
5.8
mmol/l
0.75
93
813
104
926
3.68
2.87
19.5
12.9
13.6
22.0
mg/l
3.47
89
700
12
42
3.09
2.85
4.5
2.5
0.8
1.1
%
0.45
12
42
12
44
2.94
2.64
1.8
2.8
0.0
0.1
e6/l
1.28
12
44
7
15
4.91
2.64
1.1
1.2
—
—
—
0
0
13
51
2.76
2.55
1.1
1.0
—
—
—
0
0
104
944
3.21
2.23
25.5
14.2
3.9
3.9
mmol/l
0.18
104
907
104
943
3.24
2.22
25.8
14.2
139.3
139.8
mmol/l
0.77
104
909
11
44
2.67
2.08
4.4
5.6
26.1
25.6
mmol/l
0.21
11
44
44
304
1.75
2.06
3.7
3.0
—
—
—
0
0
38
253
1.77
2.02
3.6
2.8
0.1
0.5
e6/l
1.81
32
187
31
196
1.81
1.94
1.7
1.6
—
—
—
0
0
5
12
4.31
1.84
1.4
1.2
—
—
—
0
0
14
68
2.21
1.79
1.3
1.4
—
—
—
0
0
37
253
1.70
1.76
4.4
4.0
0.0
0.0
estimate
0.00
17
87
16
83
2.09
1.75
4.8
3.8
—
—
—
0
0
97
868
2.07
1.58
17.9
12.5
80.9
82.6
ml/min/173m2
0.28
79
682
100
910
2.20
1.58
5.5
4.2
4.7
4.7
mmol/l
0.25
89
834
100
924
2.00
1.33
6.1
4.8
2.7
2.8
mmol/l
0.18
90
839
9
44
2.14
1.30
1.0
1.7
—
—
—
0
0
5
18
2.86
1.30
1.2
1.4
—
—
—
0
0
5
19
2.71
1.23
1.8
1.5
—
—
—
0
0
8
39
2.13
1.18
1.3
1.4
—
—
—
0
0
26
184
1.54
1.04
1.2
1.3
2.1
9.4
u/ml
1.20
12
75
5
22
2.33
1.04
1.6
1.0
—
—
—
0
0
20
133
1.62
1.03
1.5
1.7
—
—
—
0
0
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
7
36
2.01
0.99
1.0
1.8
—
—
—
0
0
7
37
1.95
0.96
1.0
1.8
—
—
—
0
0
97
904
1.66
0.86
5.8
4.2
1.5
1.6
mmol/l
1.20
88
821
93
863
1.53
0.79
5.2
3.8
1.4
1.2
mmol/l
1.55
85
779
28
214
1.42
0.77
2.1
2.3
329.4
6419.8
umol/l
1.30
20
182
5
25
2.05
0.73
1.4
1.3
—
—
—
0
0
20
146
1.45
0.70
2.4
2.4
0.7
0.8
e6/l
0.17
14
83
5
95
0.50
0.70
2.4
1.7
—
—
—
0
0
19
138
1.46
0.68
2.6
2.5
7.0
4.2
e6/l
0.48
13
76
13
87
1.56
0.67
1.6
1.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
6
37
1.66
0.56
1.3
1.2
—
—
—
0
0
6
37
1.66
0.56
1.3
1.2
—
—
—
0
0
6
38
1.61
0.55
1.5
1.3
—
—
—
0
0
12
84
1.48
0.52
1.5
1.7
—
—
—
0
0
7
46
1.56
0.49
1.7
1.3
—
—
—
0
0
48
425
1.23
0.45
4.8
3.9
—
—
—
0
0
21
169
1.30
0.43
7.5
3.5
38.7
170.0
ng/l
0.96
14
126
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
5
34
1.49
0.41
2.2
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
13
106
1.26
0.24
8.3
6.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
72.2
—
0
5
0
14
0.00
0.20
0.0
1.4
—
7.3
—
0
9
21
233
0.88
0.16
1.4
1.4
—
—
—
0
0
12
134
0.88
0.09
3.3
2.1
—
—
—
0
0
7
65
1.08
0.08
2.0
1.5
—
—
—
0
0
9
86
1.05
0.07
2.1
1.6
—
—
—
0
0
11
121
0.90
0.06
3.2
1.9
—
—
—
0
0
60
613
0.95
0.05
2.9
3.2
—
—
—
0
0
20
208
0.95
0.02
2.2
2.0
—
—
—
0
0
27
265
1.03
0.00
1.6
1.6
1.5
1.3
mmol/l
0.38
17
220
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
10.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
118.1
—
0
5
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
9.3
—
0
5
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
117.2
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXFAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXFAC | 1.608 [1.15, 2.24] | 0.005 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 465 females with E4_THYTOXFAC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYTOXFAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | No data |
| 5 | 1.053% | No data |
| 10 | 2.484% | No data |
| 15 | 4.999% | No data |
| 20 | 8.612% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYTOXFAC – Thyrotoxicosis factitia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data