Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
109 |
4. Check minimum number of eventsNone |
109 |
5. Include endpointsNone |
109 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis factitia
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis factitia
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of the thyroid gland
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 609 | 533 | 72 |
| Only index persons | 568 | 503 | 65 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.00 |
| Only index persons | 0.02 | 0.02 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 61.75 | 61.52 | 63.95 |
| Only index persons | 60.75 | 60.51 | 62.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 101 | 8 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.00 |
| Median age at first event (years) | 56.93 | 55.79 | 71.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
139.9
99
*
H03AA01
ATC
levothyroxine sodium; systemic
57.3
51.7
94
191
104
Kela drug reimbursment
Thyroid insufficiency
15.9
27.1
48
54
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
345.4
27.1
26
*
H03BB01
ATC
carbimazole; oral
69.0
23.4
26
5
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
8.3
19.2
51
110
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
73.7
11.9
13
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
11.6
10.9
20
21
C07AA05
ATC
propranolol; systemic
4.3
9.5
41
137
BAA60
NOMESCO Finland
Total thyroidectomy
22.4
8.7
12
6
R53
ICD-10 Finland
Malaise and fatigue
3.9
8.0
38
136
E03
ICD-10 Finland
Other hypothyroidism
5.9
7.5
21
43
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
11.2
6.7
12
12
N06AB03
ATC
fluoxetine; oral
4.7
6.5
22
56
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
19.5
6.4
9
5
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
57
48
23.80
61.79
7.0
1.8
pmol/l
4.5
4.4
0.02
51
40
(3036481) Cortisol [Moles/volume] in Serum or Plasma
36
88
5.62
14.88
2.3
2.1
nmol/l
335.9
387.4
0.81
31
82
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
31
75
5.38
12.81
1.2
1.3
iu/ml
282.4
161.5
0.48
13
30
(3015377) Calcium [Moles/volume] in Serum or Plasma
63
321
3.28
8.55
2.6
2.7
mmol/l
2.3
2.4
0.32
58
283
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
44
185
3.31
8.17
1.8
1.7
pmol/l
454.4
497.3
0.47
35
152
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
75
440
3.26
7.71
7.6
5.6
mmol/l
1.2
1.2
0.46
58
368
(3032080) INR in Blood by Coagulation assay
61
324
3.00
7.39
10.8
7.1
inr
1.2
1.2
0.01
21
107
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
65
358
3.02
7.36
2.3
1.8
pmol/l
96.6
96.1
0.02
38
158
(1761482) Bacteria [#/volume] in Urine by Culture
13
23
6.28
7.25
5.2
5.1
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
16
36
5.04
6.97
5.8
3.6
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
11
19
6.33
6.24
8.5
3.5
mmol/l
7.4
6.9
0.30
11
19
(42870588) Differential panel, method unspecified - Blood
55
299
2.69
6.05
4.1
4.9
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
11
20
6.01
5.94
8.5
3.4
mmol/l
1.3
1.5
0.55
11
20
(3019309) Folate [Moles/volume] in Red Blood Cells
34
147
2.91
5.76
1.7
1.7
nmol/l
1227.0
1195.4
0.08
27
105
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
41
202
2.65
5.38
2.6
2.0
mg/l
2.9
3.1
0.22
30
169
(3001122) Ferritin [Mass/volume] in Serum or Plasma
69
436
2.59
5.37
3.6
2.5
ug/l
79.7
74.0
0.26
64
396
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
57
335
2.47
5.10
5.7
3.8
ng/l
17.5
33.4
0.68
38
222
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
47
253
2.51
5.09
3.6
3.1
ng/l
821.2
932.2
0.12
38
208
(3002032) Base excess in Venous blood by calculation
20
68
3.38
5.03
6.1
3.5
mmol/l
2.5
2.5
0.04
15
52
(3041096) Erythrocytes [Presence] in Urine by Automated
49
272
2.46
4.93
4.6
3.3
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
75
508
2.53
4.81
5.6
4.3
mmol/l
6.9
6.5
0.62
70
463
(3012544) pH of Venous blood
20
70
3.27
4.80
6.1
3.5
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
94
715
3.29
4.73
5.0
3.9
mm/h
12.0
11.5
0.14
89
654
(3006315) Basophils [#/volume] in Blood
70
464
2.42
4.64
4.5
5.4
e9/l
0.0
0.0
0.65
61
410
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
66
427
2.38
4.62
2.6
2.1
nmol/l
80.9
76.5
0.55
58
375
(3021960) Folate [Moles/volume] in Serum or Plasma
42
223
2.44
4.60
1.5
1.4
nmol/l
16.0
23.0
3.46
37
184
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
51
296
2.36
4.57
2.6
3.0
u/l
29.5
29.3
0.02
46
283
(3013115) Eosinophils [#/volume] in Blood
71
478
2.39
4.48
4.7
5.7
e9/l
0.2
0.2
0.41
65
426
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
59
368
2.32
4.44
5.1
3.7
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
77
541
2.44
4.35
6.6
8.9
e9/l
3.6
4.0
0.78
69
478
(3001604) Monocytes [#/volume] in Blood
69
463
2.34
4.33
4.5
5.4
e9/l
0.6
0.5
0.14
61
409
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
41
222
2.36
4.25
1.6
1.2
u/ml
0.6
1.2
0.96
12
55
(3021589) Normoblasts [#/volume] in Blood
63
413
2.25
4.10
13.3
9.0
e9/l
0.0
0.0
0.06
54
339
(3019198) Lymphocytes [#/volume] in Blood
69
473
2.25
3.98
4.6
5.4
e9/l
2.0
1.8
0.72
62
419
(3041354) Potassium [Moles/volume] in Venous blood
9
15
6.43
3.90
4.4
2.9
mmol/l
3.8
3.8
—
9
15
(3033705) Calcium.ionized [Moles/volume] in Venous blood
9
15
6.43
3.90
4.4
2.9
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
9
15
6.43
3.90
4.4
2.9
mmol/l
106.1
107.9
—
9
15
(3013512) EKG study
44
256
2.21
3.78
7.5
3.8
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
25
113
2.57
3.78
1.4
2.0
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
100
846
3.20
3.52
8.6
5.1
mmol/mol
40.4
39.1
0.55
90
778
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
60
403
2.09
3.48
6.3
4.9
mmol/l
1.2
1.2
0.77
53
358
(3021601) Nitrite [Presence] in Urine by Test strip
67
471
2.10
3.42
7.2
5.0
estimate
0.0
0.0
0.00
19
87
(40760892) CBC W Ordered Manual Differential panel - Blood
38
217
2.15
3.36
3.7
5.0
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
67
474
2.07
3.33
4.8
3.7
estimate
0.0
0.0
0.00
18
86
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
37
210
2.15
3.31
1.6
1.8
mg/l
0.5
1.2
2.66
30
170
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
15
55
3.00
3.31
1.8
1.5
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
24
115
2.39
3.19
3.7
1.8
ug/g
100.8
131.6
0.25
18
83
(3035350) Ketones [Presence] in Urine by Test strip
66
471
2.02
3.12
4.9
3.7
estimate
0.0
0.0
0.00
18
87
(3018418) pH of Serum or Plasma
46
291
2.00
3.05
5.3
3.6
ph
7.4
7.4
0.53
11
53
(3016724) Homocysteine [Moles/volume] in Serum or Plasma
5
5
10.39
3.01
2.0
1.2
umol/l
6.3
10.2
—
5
5
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
102
891
3.25
2.92
6.0
4.3
mmol/l
6.0
5.8
0.75
93
813
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
104
926
3.68
2.87
19.5
12.9
mg/l
13.6
22.0
3.47
89
700
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
12
42
3.09
2.85
4.5
2.5
%
0.8
1.1
0.45
12
42
(3007164) IgA [Mass/volume] in Serum or Plasma
34
198
2.04
2.80
1.8
1.4
g/l
2.3
2.5
0.21
22
113
(3035320) C reactive protein [Mass/volume] in Body fluid
5
6
8.65
2.77
2.4
2.2
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
12
43
3.01
2.74
2.4
2.3
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
12
44
2.94
2.64
1.8
2.8
e6/l
0.0
0.1
1.28
12
44
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
7
15
4.91
2.64
1.1
1.2
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
17
76
2.47
2.60
1.4
1.1
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
13
51
2.76
2.55
1.1
1.0
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
81
645
2.00
2.54
5.4
4.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
48
324
1.86
2.53
4.1
2.8
—
—
—
0
0
(3022145) Colonoscopy Study observation
21
105
2.24
2.52
1.3
1.3
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
38
239
1.91
2.48
5.0
3.5
mg/mmol
4.5
6.8
0.25
20
145
(40761536) Microorganisms panel - Urine sediment
17
78
2.40
2.46
3.6
4.0
—
—
—
0
0
(3003181) Sodium [Moles/volume] in Urine
6
12
5.22
2.43
2.0
1.3
mmol/l
60.2
60.4
—
6
12
(3025941) Bacteria identified in Stool by Culture
14
60
2.53
2.33
1.2
1.2
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
42
279
1.82
2.28
3.5
3.0
e6/l
226.4
63.3
0.34
36
211
(3023103) Potassium [Moles/volume] in Serum or Plasma
104
944
3.21
2.23
25.5
14.2
mmol/l
3.9
3.9
0.18
104
907
(3019550) Sodium [Moles/volume] in Serum or Plasma
104
943
3.24
2.22
25.8
14.2
mmol/l
139.3
139.8
0.77
104
909
(3044889) 12 lead EKG panel
77
618
1.84
2.17
5.3
3.6
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
18
90
2.20
2.15
2.2
1.4
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
11
44
2.67
2.08
4.4
5.6
mmol/l
26.1
25.6
0.21
11
44
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
10
38
2.80
2.07
5.4
7.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
44
304
1.75
2.06
3.7
3.0
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
35
227
1.80
2.03
3.1
2.8
mg/l
20.9
31.8
0.32
20
142
(3030467) Casts [#/volume] in Urine by Automated count
38
253
1.77
2.02
3.6
2.8
e6/l
0.1
0.5
1.81
32
187
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
31
196
1.81
1.94
1.7
1.6
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
6
17
3.67
1.86
5.5
4.0
kpa
9.6
9.1
—
6
17
(3013290) Carbon dioxide [Partial pressure] in Blood
6
17
3.67
1.86
5.5
4.0
kpa
5.5
5.0
—
6
17
(3012501) Base excess in Blood by calculation
6
17
3.67
1.86
5.5
4.0
mmol/l
2.5
2.8
—
6
12
(3026389) Candida sp identified in Specimen by Organism specific culture
5
12
4.31
1.84
1.4
1.2
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
14
68
2.21
1.79
1.3
1.4
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
6
18
3.46
1.77
1.7
2.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
6
18
3.46
1.77
1.0
1.2
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
37
253
1.70
1.76
4.4
4.0
estimate
0.0
0.0
0.00
17
87
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
83
2.09
1.75
4.8
3.8
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
36
245
1.70
1.74
3.2
2.7
mmol/l
6.2
7.2
0.71
25
200
(3024354) Oxygen [Partial pressure] in Venous blood
13
63
2.21
1.67
8.8
2.7
kpa
5.1
4.2
1.86
13
63
(3002385) Erythrocyte distribution width [Ratio]
91
794
1.88
1.66
24.8
15.6
%
13.6
13.7
0.26
91
783
(3018095) Leukocytes [#/volume] in Urine
46
338
1.62
1.65
3.8
3.6
e6/l
180.4
70.1
0.30
38
228
(3052851) Hemolysis interference index of Serum or Plasma
6
20
3.11
1.60
1.5
3.0
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
97
868
2.07
1.58
17.9
12.5
ml/min/173m2
80.9
82.6
0.28
79
682
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
100
910
2.20
1.58
5.5
4.2
mmol/l
4.7
4.7
0.25
89
834
(3005719) IgG [Mass/volume] in Serum or Plasma
13
65
2.14
1.56
1.8
2.4
g/l
10.4
10.0
0.13
13
60
(1616796) Gas panel - Central venous blood
5
17
3.03
1.37
2.0
2.1
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
21
131
1.75
1.36
1.3
1.4
titre
293.3
604.8
—
6
25
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
100
924
2.00
1.33
6.1
4.8
mmol/l
2.7
2.8
0.18
90
839
(3034770) Mitochondria Ab [Titer] in Serum
6
24
2.58
1.32
1.0
1.2
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
9
44
2.14
1.30
1.0
1.7
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
8
35
2.39
1.30
1.1
1.1
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
5
18
2.86
1.30
1.2
1.4
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
94
847
1.80
1.29
20.5
13.2
%
37.1
39.5
0.94
56
634
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
5
19
2.71
1.23
1.8
1.5
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
20
128
1.69
1.19
1.2
1.2
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
8
39
2.13
1.18
1.3
1.4
—
—
—
0
0
(3000492) Spirometry study
13
73
1.89
1.17
1.7
1.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
34
251
1.52
1.14
3.7
2.7
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
30
217
1.53
1.10
4.5
3.8
kg/l
1.0
1.0
—
7
29
(3026008) Bacteria identified in Urine by Culture
41
318
1.46
1.07
3.7
2.8
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
26
184
1.54
1.04
1.2
1.3
u/ml
2.1
9.4
1.20
12
75
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
5
22
2.33
1.04
1.6
1.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
20
133
1.62
1.03
1.5
1.7
—
—
—
0
0
(3019060) Gas panel - Arterial blood
9
48
1.95
1.03
5.0
4.9
—
—
—
0
0
(3008898) HLA-B27 [Presence]
9
48
1.95
1.03
1.2
1.1
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
7
36
2.01
0.99
1.0
1.8
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
7
37
1.95
0.96
1.1
1.8
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
7
37
1.95
0.96
1.0
1.8
—
—
—
0
0
(3022621) pH of Urine by Test strip
10
55
1.90
0.95
1.8
2.6
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
9
52
1.80
0.95
1.6
1.8
g/l
1.9
1.9
—
9
46
(3022313) Gas panel - Capillary blood
6
28
2.21
0.93
1.5
4.1
—
—
—
0
0
(3000991) Gas panel - Venous blood
10
57
1.83
0.87
3.2
7.6
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
97
904
1.66
0.86
5.8
4.2
mmol/l
1.5
1.6
1.20
88
821
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
93
863
1.53
0.79
5.2
3.8
mmol/l
1.4
1.2
1.55
85
779
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
28
214
1.42
0.77
2.1
2.3
umol/l
329.4
6419.8
1.30
20
182
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
25
2.05
0.73
1.4
1.3
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
20
146
1.45
0.70
2.4
2.4
e6/l
0.7
0.8
0.17
14
83
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
5
95
0.50
0.70
2.4
1.7
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
5
27
1.89
0.69
1.0
2.0
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
19
138
1.46
0.68
2.6
2.5
e6/l
7.0
4.2
0.48
13
76
(4094501)
5
28
1.82
0.67
1.0
1.0
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
13
87
1.56
0.67
1.6
1.7
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
5
30
1.70
0.62
1.0
1.5
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
6
37
1.66
0.56
1.3
1.2
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
6
37
1.66
0.56
1.3
1.2
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
6
37
1.66
0.56
1.3
1.2
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
34
282
1.30
0.56
2.3
2.0
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
6
38
1.61
0.55
1.5
1.3
—
—
—
0
0
(1002224) Polysomnography panel
6
40
1.53
0.52
1.0
1.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
12
84
1.48
0.52
1.5
1.7
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
7
46
1.56
0.49
1.7
1.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
48
425
1.23
0.45
4.8
3.9
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
6
95
0.61
0.44
3.8
1.6
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
21
169
1.30
0.43
7.5
3.5
ng/l
38.7
170.0
0.96
14
126
(3003740) Influenza virus B Ag [Presence] in Specimen
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
5
34
1.49
0.41
2.2
1.6
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
14
107
1.35
0.39
1.3
1.3
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
20
243
0.78
0.39
1.4
1.5
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
5
36
1.41
0.38
1.0
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
14
108
1.34
0.37
1.1
1.3
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
5
80
0.61
0.37
1.2
1.3
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
6
41
1.49
0.36
5.8
9.7
%
92.8
95.2
—
6
41
(3023368) Bacteria identified in Blood by Culture
25
215
1.21
0.30
3.6
3.8
—
—
—
0
0
(40758558) Short blood count panel - Blood
28
244
1.20
0.30
4.4
6.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
21
179
1.21
0.27
2.1
1.7
—
—
—
0
0
(4035726)
12
95
1.30
0.27
1.2
1.3
—
—
—
0
0
(3019225) pH of Specimen
10
77
1.33
0.27
4.0
3.4
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
5
70
0.70
0.27
2.2
1.5
—
—
—
0
0
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
9
74
1.24
0.26
2.1
2.4
g/l
0.2
0.2
—
9
69
(4010399)
9
74
1.24
0.26
1.6
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
13
106
1.26
0.24
8.3
6.8
—
—
—
0
0
(3003338) MCHC [Mass/volume]
82
787
1.17
0.24
23.9
16.8
g/l
332.2
331.3
0.44
82
782
(3028300) Cannabinoids [Presence] in Urine
5
37
1.37
0.24
1.0
1.4
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
5
37
1.37
0.24
1.0
1.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
5
37
1.37
0.24
1.0
1.4
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
5
38
1.33
0.23
1.0
1.4
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
25
221
1.17
0.23
2.7
3.3
%
95.4
94.7
0.04
25
216
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
11
89
1.26
0.22
1.7
2.0
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum
0
10
0.00
0.21
0.0
1.3
—
72.2
—
0
5
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(4281824)
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose
0
14
0.00
0.20
0.0
1.4
—
7.3
—
0
9
(3001019) Free T4 and TSH panel - Serum or Plasma
7
60
1.18
0.18
4.4
1.9
—
—
—
0
0
(3002256) Pathology report gross observation
14
120
1.19
0.17
1.1
1.2
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
21
233
0.88
0.16
1.4
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
12
134
0.88
0.09
3.3
2.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
6
53
1.14
0.09
2.7
2.5
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
7
65
1.08
0.08
2.0
1.5
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
43
414
1.06
0.07
2.1
2.0
—
—
—
0
0
(40761535) Cells panel - Urine sediment
8
78
1.03
0.07
3.4
2.8
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
9
86
1.05
0.07
2.1
1.6
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
14
152
0.91
0.06
1.4
1.5
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
11
121
0.90
0.06
3.2
1.9
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
60
613
0.95
0.05
2.9
3.2
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
20
208
0.95
0.02
2.2
2.0
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
21
213
0.98
0.00
4.6
3.6
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
27
265
1.03
0.00
1.6
1.6
mmol/l
1.5
1.3
0.38
17
220
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
10
95
1.06
0.00
1.2
1.5
—
—
—
0
0
(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3017817) Protein [Mass] in Urine collected for unspecified duration
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
8.3
—
962.2
—
0
6
(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
5
0.00
0.00
0.0
1.0
—
6.2
—
0
5
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(4268621)
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(4024509)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028679) Herpes simplex virus Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate
0
5
0.00
0.00
0.0
10.4
—
—
—
0
0
(3035947) Staphylolysin Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
5
0.00
0.00
0.0
1.0
—
118.1
—
0
5
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
0.8
—
0
6
(3023199) Leukocytes [#/volume] in Pleural fluid
0
5
0.00
0.00
0.0
1.0
—
700.4
—
0
5
(3047189) Immunofixation for 24 hour Urine
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
6
0.00
0.00
0.0
5.7
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
9.3
—
0
5
(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
117.2
—
0
5
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013727) Leukocytes other/100 leukocytes in Blood
0
6
0.00
0.00
0.0
6.2
—
45.7
—
0
6
(3045716) Anion gap in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
7.0
—
0
6
(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
37.4
—
0
6
(3045142) Bone marrow Pathology biopsy report
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(21494890) Protein electrophoresis panel - 24 hour Urine
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
69
1.02
0.00
1.1
1.3
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
17.8
—
1733.3
—
0
6
(3013139) Helicobacter pylori Ag [Presence] in Stool
5
56
0.89
0.00
1.8
1.2
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036782) Glucose [Moles/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
7.0
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXFAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXFAC | 1.608 [1.15, 2.24] | 0.005 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 465 females with E4_THYTOXFAC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYTOXFAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | No data |
| 5 | 1.053% | No data |
| 10 | 2.484% | No data |
| 15 | 4.999% | No data |
| 20 | 8.612% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYTOXFAC – Thyrotoxicosis factitia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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