epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
219 |
4. Check minimum number of eventsNone |
219 |
5. Include endpointsNone |
219 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G405
- Name in latin
- Ictus epileptici ex usu alcohol
Similar endpoints
↥List of similar endpoints to
Epileptic seizures related to alcohol
based on the number of shared cases.
Similar with more cases:
- Epilepsy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3694 | 714 | 2952 |
| Only index persons | 2804 | 567 | 2237 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.02 | 0.08 |
| Only index persons | 0.07 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 51.05 | 51.18 |
| Only index persons | 51.40 | 51.11 | 51.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 211 | 44 | 167 |
| Unadjusted period prevalence (%) | 0.06 | 0.02 | 0.08 |
| Median age at first event (years) | 51.99 | 47.35 | 53.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 219
- Matched controls
- 2190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G40.51
ICD-10 Finland
Epileptic seizures related to alcohol
+∞
317.2
219
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
79.7
240.3
156
66
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
47.4
193.8
159
116
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
101.1
140.1
74
11
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
27.9
107.3
82
46
G40.9
ICD-10 Finland
Epilepsy, unspecified
31.1
100.7
72
34
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
21.4
89.9
77
54
P15
ICPC
Chronic alcohol abuse
24.0
88.0
70
42
F10.25
ICD-10 Finland
Alcohol dependence continuous use
29.5
76.3
54
24
F10.20
ICD-10 Finland
Alcohol dependence currently independent
27.2
74.0
54
26
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
41.3
73.4
46
14
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
31.2
65.7
45
18
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
34.4
63.6
42
15
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
31.2
63.0
43
17
F10.09
ICD-10 Finland
Alcohol intoxication UNS
21.1
62.8
51
31
N03AX14
ATC
levetiracetam; systemic
23.4
62.2
48
26
F10.24
ICD-10 Finland
Alcohol depence active use
23.7
57.8
44
23
N03AG01
ATC
valproic acid; systemic, rectal
12.5
53.2
60
64
N07BB01
ATC
disulfiram; oral
11.6
53.2
64
75
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
23.5
51.4
39
20
N03AF01
ATC
carbamazepine; oral, rectal
13.5
51.2
54
52
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
21.7
48.4
38
21
AA1AD
NOMESCO Finland
CT of head and brain
6.8
45.1
127
371
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.9
38.6
120
373
T36
ICD-10 Finland
Poisoning by systemic antibiotics
10.8
37.7
45
51
N03AF02
ATC
oxcarbazepine; oral
13.0
37.5
39
36
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
16.7
37.3
33
23
S01.0
ICD-10 Finland
Open wound of scalp
7.7
35.5
59
100
N05BA02
ATC
chlordiazepoxide; systemic
13.2
34.4
35
31
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.8
33.4
83
208
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
12.8
32.8
34
31
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.7
31.8
35
35
W19
ICD-10 Finland
Unspecified fall
7.3
31.5
54
94
N05BA01
ATC
diazepam; systemic, rectal
5.6
29.7
72
175
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
25.1
25.8
36
17
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
37.2
25.4
32
10
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
43.1
24.7
30
8
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
76.5
24.4
27
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
70.1
22.4
25
*
N06AB04
ATC
citalopram; systemic
4.3
21.1
72
225
S06.0
ICD-10 Finland
Concussion
5.1
20.7
51
123
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
21.5
20.6
30
16
F10.06
ICD-10 Finland
Alcohol-related acute intoxication with seizures
80.9
20.1
22
*
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
24.5
20.1
28
13
X59
ICD-10 Finland
Exposure to unspecified factor
3.9
18.5
74
256
G40
ICD-10 Finland
Epilepsy
29.7
18.2
24
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
17.9
71
244
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.6
17.7
49
129
N06AX11
ATC
mirtazapine; oral
3.3
17.3
107
486
P16
ICPC
Acute alcohol abuse
13.2
16.6
29
25
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
27.0
16.4
22
9
N05AA02
ATC
levomepromazine; systemic
6.2
16.2
30
55
N05CF01
ATC
zopiclone; oral
3.2
15.9
98
440
N05AH04
ATC
quetiapine; oral
3.6
15.5
66
235
A98
ICPC
Health maint/preventive medicine
0.3
15.5
160
1995
K70.1
ICD-10 Finland
Alcoholic hepatitis
61.1
15.0
17
*
E87.6
ICD-10 Finland
Hypokalaemia
7.2
14.8
23
35
N05CD07
ATC
temazepam; oral
4.1
14.5
46
133
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.0
14.3
24
19
N03AB02
ATC
phenytoin; systemic
17.3
14.3
22
14
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
15.0
14.1
23
17
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
14.2
13.2
22
17
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
30.5
13.2
17
6
Z72.1
ICD-10 Finland
Alcohol use
14.4
12.7
21
16
W10
ICD-10 Finland
Fall on and from stairs and steps
5.4
12.0
25
51
N05AB01
ATC
dixyrazine; systemic
13.6
11.9
20
16
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
24.5
11.7
16
7
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
11.7
42
132
N03AX09
ATC
lamotrigine; oral
5.9
11.6
22
41
V03AA01, ,
ATC
9.7
11.6
23
26
S06.3
ICD-10 Finland
Focal brain injury
18.3
11.4
17
10
R41.0
ICD-10 Finland
Disorientation, unspecified
9.7
11.1
22
25
WX892
NOMESCO Finland
Monitored bed care
4.1
10.9
32
87
N03AX18
ATC
lacosamide; systemic
22.9
10.8
15
7
C03CA01
ATC
furosemide; systemic
2.8
10.7
73
335
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
13.0
10.6
18
15
WX730
NOMESCO Finland
Conventional respirator
17.1
10.5
16
10
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
11.4
10.5
19
18
N88
ICPC
Epilepsy
34.4
10.4
13
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
20.0
10.4
15
8
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
14.1
10.3
17
13
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
10.2
54
215
F05.9
ICD-10 Finland
Delirium, unspecified
15.6
10.2
16
11
G40.89
ICD-10 Finland
Other epilepsy
42.1
10.1
12
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
14.3
9.8
16
12
C07AA05
ATC
propranolol; systemic
2.8
9.8
60
258
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
104.4
9.5
10
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
22.9
9.5
13
6
G72.8
ICD-10 Finland
Other specified myopathies
10.7
9.2
17
17
183
Kela drug reimbursment
Lamotrigin and topiramate
16.5
9.2
14
9
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
19.6
9.0
13
7
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
25.3
9.0
12
5
A06AD11
ATC
lactulose; oral
3.3
9.0
38
132
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.5
9.0
23
56
N05BA04
ATC
oxazepam; oral
2.6
9.0
67
318
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.6
8.9
22
52
N06AA12
ATC
doxepin; systemic
4.6
8.9
22
52
R55
ICD-10 Finland
Syncope and collapse
3.3
8.8
36
122
N07
ICPC
Convulsion/seizure
52.1
8.7
10
*
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
52.1
8.7
10
*
S42.2
ICD-10 Finland
Fracture of upper end of humerus
6.9
8.7
21
33
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
8.6
67
324
R40.2
ICD-10 Finland
Coma, unspecified
21.0
8.6
12
6
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
21.0
8.6
12
6
G40.50
ICD-10 Finland
Epilepsia partialis continua [Kozhevnikof]
93.5
8.5
9
*
G41.0
ICD-10 Finland
Grand mal status epilepticus
93.5
8.5
9
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.9
8.3
19
42
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.7
8.3
28
84
K70.0
ICD-10 Finland
Alcoholic fatty liver
18.0
8.2
12
7
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
7.7
8.1
18
25
K92.0
ICD-10 Finland
Haematemesis
8.3
8.0
17
22
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
7.8
28
87
Z2446
NOMESCO Finland
Social worker
3.8
7.8
25
72
K29.2
ICD-10 Finland
Alcoholic gastritis
46.7
7.8
9
*
S00.0
ICD-10 Finland
Superficial injury of scalp
8.5
7.7
16
20
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
26.0
7.6
10
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
7.6
40
157
R11
ICD-10 Finland
Nausea and vomiting
3.6
7.5
26
79
F10.05
ICD-10 Finland
Alcohol-related acute intoxication with coma
82.8
7.5
8
*
G40.10
ICD-10 Finland
Simple partial seizures
82.8
7.5
8
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
82.8
7.5
8
*
2918A
ICD-9 Finland
Alcoholic psychoses, Other specified alcoholic psychosis
+∞
7.3
7
*
SPAT1227
SPAT
Substance abuse rehabilitation
16.4
7.3
11
7
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
7.3
34
125
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.6
7.2
25
76
P18
ICPC
Medication abuse
31.1
7.2
9
*
N05AX08
ATC
risperidone; systemic
3.4
7.1
27
87
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.5
7.1
13
13
X58
ICD-10 Finland
Exposure to other specified factors
2.7
7.0
43
183
A28
ICPC
Limited function/disability NOS
2.8
7.0
37
146
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
11.5
6.9
12
11
N06AB03
ATC
fluoxetine; oral
2.9
6.9
35
135
WX872
NOMESCO Finland
Intensive care
3.4
6.8
25
79
G40.59
ICD-10 Finland
Other special epileptic syndromes
41.4
6.8
8
*
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
23.3
6.7
9
*
S06.2
ICD-10 Finland
Diffuse brain injury
23.3
6.7
9
*
N05AD03
ATC
melperone; systemic
12.8
6.7
11
9
WX882
NOMESCO Finland
High dependency care
7.2
6.6
15
22
N03AE01
ATC
clonazepam; systemic
3.8
6.6
21
60
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.2
6.6
28
97
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
71.9
6.5
7
*
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
5.9
6.4
17
31
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
7.4
6.3
14
20
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
18.7
6.3
9
5
SPD00
NOMESCO Finland
Mucosa borne complete denture
18.7
6.3
9
5
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
6.3
6
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
6.2
26
89
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
6.2
25
84
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
6.2
28
101
N05BE01
ATC
buspirone; oral
5.5
6.2
17
33
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
9.0
6.1
12
14
T74.1
ICD-10 Finland
Physical abuse
9.0
6.1
12
14
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
9.0
6.1
12
14
SPAT1265
SPAT
Breathalyser
10.5
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
280
4.08
21.25
4.3
2.0
2.06
1.65
%
2.31
73
251
137
1847
0.31
14.80
4.4
4.5
1.44
1.36
mmol/l
0.99
129
1727
138
1852
0.31
14.66
4.7
4.6
4.55
4.59
mmol/l
0.15
131
1741
131
1799
0.32
14.23
4.2
4.1
1.42
1.35
mmol/l
0.32
121
1678
143
1878
0.31
14.06
5.2
5.0
2.54
2.76
mmol/l
1.90
136
1756
60
222
3.35
13.08
8.0
8.3
1.51
1.11
mmol/l
0.29
47
176
74
321
2.97
12.21
3.6
3.6
0.75
0.83
mmol/l
4.66
68
304
177
2058
0.27
11.69
39.4
20.6
37.67
41.39
%
6.98
155
1943
107
581
2.65
11.27
5.0
2.8
59.65
65.64
u/l
0.30
101
545
139
1802
0.37
10.44
5.0
4.5
6.18
6.03
mmol/l
0.47
128
1670
63
284
2.71
9.38
1.7
1.6
1058.13
1237.74
nmol/l
0.91
54
221
62
304
2.45
7.60
2.0
2.1
29.69
29.83
s
0.08
57
298
45
189
2.74
7.57
1.8
1.8
—
—
—
0
0
123
811
2.18
7.34
11.5
7.8
1.18
1.21
mmol/l
3.23
108
699
45
192
2.69
7.33
1.8
1.9
—
—
—
0
0
115
744
2.15
7.15
9.1
6.5
1.17
1.21
mmol/l
4.86
110
688
141
1754
0.45
6.99
24.1
13.0
89.77
83.37
ml/min/173m2
2.11
113
1458
173
1979
0.40
6.43
31.3
16.7
77.08
81.76
umol/l
0.54
173
1979
103
660
2.06
6.35
5.2
3.9
48.26
34.18
u/l
2.66
97
629
61
321
2.25
6.24
6.9
3.7
463.30
284.74
ng/l
0.18
52
247
52
266
2.25
5.65
2.0
1.9
—
—
—
0
0
9
8
11.66
5.34
3.4
2.3
39.56
60.13
umol/l
—
9
8
33
656
0.41
5.31
2.4
2.8
0.55
0.71
ug/l
1.22
22
411
35
159
2.43
4.95
7.2
3.7
1.73
2.02
mmol/l
0.17
30
127
57
894
0.51
4.57
4.2
4.1
22.21
21.52
%
0.14
28
400
106
746
1.82
4.49
6.9
5.7
33.10
35.70
g/l
3.58
99
707
116
843
1.80
4.38
12.0
12.7
1.12
1.27
inr
2.20
31
233
43
226
2.12
4.31
3.3
3.3
10.18
10.09
umol/l
0.01
37
202
146
1725
0.54
4.22
6.0
5.7
39.79
40.17
mmol/mol
0.14
134
1639
59
361
1.87
3.83
4.4
3.4
1.01
1.02
kg/l
3.33
14
44
137
1076
1.73
3.70
9.7
4.9
6.67
6.79
mmol/l
0.25
130
1020
133
1054
1.67
3.31
5.2
3.5
11902.20
47.15
e6/l
—
5
20
6
195
0.29
3.13
2.5
1.8
—
—
—
0
0
0
79
0.00
3.01
0.0
1.9
—
246.22
—
0
73
22
102
2.29
2.98
1.5
1.5
—
—
—
0
0
59
387
1.72
2.98
2.8
1.9
2.58
3.16
mg/l
1.65
49
346
26
130
2.13
2.95
1.8
1.6
—
—
—
0
0
20
91
2.32
2.83
5.0
2.5
1.94
1.29
%
0.91
20
91
135
1577
0.62
2.78
4.3
4.0
1.91
1.98
mu/l
0.31
126
1442
19
87
2.30
2.66
5.2
2.5
0.73
0.63
%
0.80
19
87
12
44
2.83
2.59
1.3
1.6
138.67
286.51
ug/g
—
6
28
22
117
1.98
2.15
3.0
2.9
0.85
1.59
mmol/l
0.27
14
89
13
257
0.47
1.88
1.2
2.2
15.48
13.90
nmol/l
0.30
13
238
81
636
1.43
1.76
4.2
2.9
—
—
—
0
0
0
48
0.00
1.72
0.0
1.1
—
6.27
—
0
6
29
183
1.67
1.68
6.0
3.3
—
—
—
0
0
43
301
1.53
1.64
3.4
2.6
1.96
1.02
e6/l
0.78
23
181
63
479
1.44
1.61
4.4
2.9
0.63
0.49
e6/l
0.12
51
364
101
835
1.39
1.60
4.4
3.2
0.00
0.01
estimate
0.50
18
160
19
108
1.83
1.56
1.9
1.4
—
—
—
0
0
93
1106
0.72
1.55
3.0
2.7
—
—
—
0
0
7
27
2.64
1.52
1.0
1.5
—
—
—
0
0
100
833
1.37
1.49
2.9
2.6
—
—
—
0
0
10
45
2.28
1.48
2.2
1.7
23.17
24.32
mmol/l
—
10
45
34
233
1.54
1.43
4.1
2.4
27.23
22.35
%
0.72
26
207
57
441
1.40
1.31
5.2
3.3
0.00
0.02
estimate
0.50
17
143
169
1811
0.71
1.29
27.8
14.1
26.87
23.86
mg/l
0.63
147
1443
6
25
2.44
1.25
5.3
3.8
101.00
104.60
mmol/l
—
6
25
8
37
2.21
1.23
1.1
1.5
—
—
—
0
0
8
40
2.04
1.13
1.4
2.8
—
—
—
0
0
5
21
2.41
1.09
1.2
1.8
—
—
—
0
0
5
21
2.41
1.09
1.2
1.8
—
—
—
0
0
10
52
1.97
1.08
1.5
1.2
—
—
—
0
0
7
33
2.16
1.06
1.1
1.4
—
—
—
0
0
98
845
1.29
1.06
4.5
3.2
0.00
0.00
estimate
-0.00
18
138
147
1338
1.30
1.03
8.2
3.3
148.84
55.47
u/l
4.34
142
1273
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.0
—
22.67
—
0
6
38
289
1.38
0.97
3.4
2.7
1.72
1.06
e6/l
0.47
19
170
116
1288
0.79
0.96
3.5
3.9
18.61
11.00
mm/h
4.11
109
1197
78
660
1.28
0.96
5.0
3.3
—
—
—
0
0
18
264
0.65
0.94
1.3
1.2
26.14
44.50
iu/ml
—
7
84
8
43
1.89
0.88
1.1
1.5
—
—
—
0
0
41
512
0.75
0.86
2.0
1.7
1.41
1.45
mmol/l
0.12
34
438
95
833
1.25
0.85
6.0
4.4
0.00
0.00
estimate
-0.00
19
154
6
114
0.51
0.85
1.0
1.5
—
—
—
0
0
8
45
1.81
0.85
1.3
1.8
—
—
—
0
0
8
45
1.81
0.85
1.3
1.8
—
—
—
0
0
63
529
1.27
0.82
2.7
4.2
2.33
2.35
mmol/l
0.34
51
468
8
47
1.73
0.81
1.8
2.7
—
—
—
0
0
51
417
1.29
0.81
2.4
2.4
—
—
—
0
0
6
33
1.84
0.79
1.0
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.0
—
1.03
—
0
9
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
161.16
—
0
27
9
55
1.66
0.74
1.4
1.2
—
—
—
0
0
7
39
1.82
0.73
1.6
1.3
—
—
—
0
0
5
25
2.02
0.73
2.4
1.2
—
—
—
0
0
81
712
1.22
0.69
6.1
3.6
34.64
37.68
ng/l
0.08
61
504
5
27
1.87
0.69
1.2
1.4
—
—
—
0
0
46
381
1.26
0.67
1.8
1.8
1.23
1.39
mg/l
0.17
35
301
5
29
1.74
0.64
1.2
1.5
—
—
—
0
0
5
29
1.74
0.64
1.2
1.5
—
—
—
0
0
75
660
1.21
0.63
3.8
2.5
235.38
174.66
ug/l
1.08
70
614
5
30
1.68
0.62
1.2
2.0
—
—
—
0
0
5
30
1.68
0.62
1.2
2.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
2.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
7
47
1.51
0.48
1.3
1.2
—
—
—
0
0
7
47
1.51
0.48
1.3
1.2
—
—
—
0
0
74
666
1.17
0.47
2.6
1.9
86.77
95.31
pmol/l
0.73
47
368
5
32
1.58
0.42
3.6
3.4
62.20
55.09
%
—
5
32
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
8
113
0.70
0.38
1.0
1.3
—
55.02
—
0
12
17
212
0.79
0.37
4.2
4.9
219.82
259.85
u/l
1.29
17
203
22
262
0.82
0.33
1.7
1.5
—
—
—
0
0
32
278
1.18
0.32
2.1
3.5
2.45
2.44
mmol/l
0.28
26
239
109
1031
1.11
0.31
8.2
11.1
4.29
4.13
e9/l
0.24
96
902
12
148
0.80
0.25
2.0
2.0
—
—
—
0
0
5
38
1.32
0.23
2.4
1.6
—
—
—
0
0
5
39
1.29
0.23
1.2
1.2
—
—
—
0
0
10
124
0.80
0.22
1.9
2.4
—
17.49
—
0
9
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
1.00
—
0
6
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
843.67
—
0
12
0
13
0.00
0.21
0.0
3.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
11
133
0.82
0.20
2.0
1.9
—
—
—
0
0
49
525
0.91
0.18
2.5
3.0
2040.72
983.93
ng/l
0.98
43
440
55
585
0.92
0.18
3.7
3.7
21.42
10.52
mg/mmol
0.34
34
390
21
186
1.14
0.17
3.0
5.2
18.73
76.94
ug/l
0.70
21
160
5
60
0.83
0.08
1.4
1.5
—
—
—
0
0
5
62
0.80
0.08
1.4
1.9
—
—
—
0
0
5
65
0.76
0.08
1.2
3.0
—
1.28
—
0
5
8
75
1.07
0.07
1.3
1.3
—
—
—
0
0
32
332
0.96
0.04
1.2
1.2
0.75
1.00
u/ml
—
10
101
49
503
0.97
0.04
2.5
2.7
353.02
5212.40
umol/l
1.55
42
443
22
212
1.04
0.02
15.8
7.7
—
—
—
0
0
14
136
1.03
0.00
2.1
2.5
57.83
67.69
ml/min/173m2
—
6
59
0
9
0.00
-0.00
0.0
4.1
—
118.30
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
1.0
—
162.40
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
51
0.98
-0.00
1.8
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
57
0.87
-0.00
1.4
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
112.06
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
74
0.94
-0.00
3.4
3.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1569.20
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
21.67
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint EPISEIZALCO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 9.296 [7.52, 11.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.38 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 611 females with EPISEIZALCO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 6.956 [6.12, 7.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1235 out of 2499 males with EPISEIZALCO died.
Mortality risk
Mortality risk for people of age
years, who have EPISEIZALCO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.35% | 1.289% |
| 5 | 5.042% | 6.949% |
| 10 | 12.988% | 16.759% |
| 15 | 22.412% | 29.851% |
| 20 | 38.968% | 47.135% |
Relationships between endpoints
↥Index endpoint: EPISEIZALCO – Epileptic seizures related to alcohol
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data