Other specified/unspecified disorders of tympanic membrane

H8_MYRINGNAS

tympanic membrane disease: A disease involving the tympanic membrane.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H73.8, H73.9 Hospital discharge: ICD-9 — 384[8-9] Cause of death: ICD-10 — H73.8, H73.9 Cause of death: ICD-9 — 384[8-9] 2 out of 7 registries used, show all original rules.	122
4. Check minimum number of events None	122
5. Include endpoints None	122
6. Filter based on genotype QC (FinnGen only)	122

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_MYRINGNAS
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H73[8-9]
HD_ICD_9	384[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H73[8-9]
COD_ICD_9	384[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified/unspecified disorders of tympanic membrane based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1266	625	640
Only index persons	1097	546	551
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	23.61	27.60	19.73
Only index persons	30.17	35.67	24.73

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	122	64	58
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	55.25	47.69	63.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
108: Matched controls
1080

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H73.8

ICD-10 Finland

Other specified disorders of tympanic membrane

+∞

74.9

H73.9

ICD-10 Finland

Disorder of tympanic membrane, unspecified

+∞

43.8

UDC00

NOMESCO Finland

Ear microscopy

24.0

30.6

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

288.8

23.6

H66.0

ICD-10 Finland

Acute suppurative otitis media

16.1

22.6

DFF00

NOMESCO Finland

Pure tone audiometry

16.1

21.0

H65.3

ICD-10 Finland

Chronic mucoid otitis media

+∞

20.5

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

75.9

17.4

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

17.1

Z01.1

ICD-10 Finland

Examination of ears and hearing

7.8

16.4

H65.2

ICD-10 Finland

Chronic serous otitis media

+∞

14.9

H66.9

ICD-10 Finland

Otitis media, unspecified

17.9

14.9

DC1AD

NOMESCO Finland

Temporalbone CT

133.7

11.7

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

36.5

10.6

DCD00

NOMESCO Finland

Myringoplasty

+∞

10.6

DFF15

NOMESCO Finland

Speech audiometry

14.4

8.7

H60.3

ICD-10 Finland

Other infective otitis externa

16.2

8.4

H66.4

ICD-10 Finland

Suppurative otitis media, unspecified

+∞

8.4

R01AD08

ATC

fluticasone; nasal

3.6

8.4

183

H60.9

ICD-10 Finland

Otitis externa, unspecified

6.6

7.9

H72.9

ICD-10 Finland

Perforation of tympanic membrane, unspecified

+∞

7.4

3812A

ICD-9 Finland

Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media

+∞

7.4

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

+∞

7.4

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

32.4

7.3

WX720

NOMESCO Finland

Own respiration

10.4

7.0

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

18.2

6.9

H73.0

ICD-10 Finland

Acute myringitis

42.8

6.9

TDA90

NOMESCO Finland

Removal wax from ear

28.5

6.3

3848X

ICD-9 Finland

Other disorders of tympanic membrane, Other specified disorders of tympanic membrane

+∞

6.3

H73.1

ICD-10 Finland

Chronic myringitis

+∞

6.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.8

6.2

426

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

3.9

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

107

4.02

9.82

1.9

1.5

—

(3019150) Specific gravity of Urine by Refractometry

224

2.42

4.84

5.1

3.7

1.0

kg/l

—

(3009508) Creatinine [Moles/volume] in Urine

298

2.15

3.96

4.0

3.1

7.8

8.0

mmol/l

0.10

253

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

168

2.32

3.81

5.1

4.0

581.5

69.5

ng/l

0.69

127

(3012516) Albumin [Mass/volume] in Urine

272

2.11

3.67

4.2

3.4

30.7

326.4

mg/l

0.70

179

(3022217) INR in Platelet poor plasma by Coagulation assay

112

2.42

3.34

12.7

21.5

1.2

inr

—

(3020682) Albumin/Creatinine [Ratio] in Urine

288

1.96

3.05

4.7

4.1

3.2

14.4

mg/mmol

2.12

184

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.35

2.85

2.0

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.91

2.82

9.3

9.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

471

1.81

2.65

13.0

7.3

1.2

mmol/l

0.22

408

(3015377) Calcium [Moles/volume] in Serum or Plasma

311

1.83

2.56

5.9

3.3

2.3

2.4

mmol/l

1.96

265

(3026008) Bacteria identified in Urine by Culture

286

1.78

2.26

3.4

2.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

739

1.83

2.24

6.1

4.0

14.4

14.7

pmol/l

0.90

659

(3000494) Fungus identified in Specimen by Culture

119

2.04

2.14

2.1

1.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.30

1.97

1.2

—

31.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.69

1.96

1.0

1.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

278

1.65

1.74

2.1

97.2

382.1

u/l

0.68

267

(3037467) Urinalysis macro (dipstick) panel - Urine

680

1.63

1.72

6.9

4.1

—

(3032080) INR in Blood by Coagulation assay

388

1.59

1.70

12.7

8.8

1.5

1.2

inr

0.65

119

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

370

1.60

1.69

1.9

97.5

95.1

pmol/l

0.14

190

(3013826) Glucose [Moles/volume] in Serum or Plasma

586

1.56

1.58

7.2

4.8

6.6

6.8

mmol/l

0.37

538

(3037756) Immunofixation for Serum or Plasma

2.95

1.52

1.3

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.05

1.44

1.5

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

282

1.56

1.42

5.7

4.7

20.0

20.7

0.10

144

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

2.50

1.41

1.4

1.6

—

0.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

759

1.57

1.41

4.8

4.2

9.6

10.8

mm/h

0.47

698

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

392

1.52

1.41

5.3

3.8

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

148

1.68

1.32

2.1

2.6

27.4

29.6

1.90

143

(40760888) Immunoglobulin light chains.free panel - Serum

2.85

1.30

6.2

4.1

—

(1761868) Lipid panel - Serum or Plasma

335

0.61

1.28

2.7

2.9

—

(3021589) Normoblasts [#/volume] in Blood

463

0.66

1.26

10.4

9.4

0.0

e9/l

0.24

384

(3020564) Creatinine [Moles/volume] in Serum or Plasma

113

1055

1.96

1.19

20.4

16.3

81.7

76.6

umol/l

0.44

113

1055

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

471

1.44

1.17

3.9

4.2

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.56

1.16

4.8

9.6

—

679.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

1.16

0.0

1.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

100

905

1.58

1.13

6.4

5.7

38.8

39.7

mmol/mol

0.53

847

(3009261) Glucose [Presence] in Urine by Test strip

503

1.43

1.12

4.8

3.7

0.0

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

495

1.42

1.09

4.8

3.6

0.0

estimate

—

102

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

103

942

1.60

1.06

5.0

4.5

5.9

mmol/l

0.11

870

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

177

1.52

0.99

1.1

1.3

10.3

31.8

iu/ml

—

(3021601) Nitrite [Presence] in Urine by Test strip

497

1.36

0.90

7.4

5.0

0.0

estimate

—

103

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.98

0.85

1.0

2.3

—

(3019060) Gas panel - Arterial blood

1.76

0.85

10.9

4.2

—

(40758558) Short blood count panel - Blood

265

1.39

0.83

6.9

7.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

149

1.49

0.82

1.4

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.80

0.0

2.7

—

69.9

—

(3044889) 12 lead EKG panel

654

1.33

0.79

5.1

3.8

—

(42870588) Differential panel, method unspecified - Blood

351

1.35

0.79

7.5

6.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

161

1.45

0.75

2.5

2.9

3.1

2.7

e6/l

0.11

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.96

0.71

1.2

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.70

0.71

1.3

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

291

1.34

0.70

4.3

3.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.89

0.69

1.4

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

1.0

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.75

0.64

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

371

1.29

0.63

2.9

3.8

38.1

31.5

ng/l

0.13

252

(3044640) Blood type and Crossmatch panel - Blood

333

1.30

0.63

1.7

2.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.69

0.62

2.2

1.6

—

(3022145) Colonoscopy Study observation

111

0.61

1.1

1.4

—

(3000492) Spirometry study

1.52

0.61

1.2

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

205

0.69

0.60

2.7

2.5

3.1

4.4

e6/l

0.69

182

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.54

0.60

1.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

159

0.66

0.59

5.0

2.3

10.1

13.9

umol/l

1.67

145

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.59

0.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.59

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

122

0.63

0.58

2.6

1.9

—

(1002224) Polysomnography panel

1.70

0.57

1.0

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.65

0.56

1.2

1.3

—

(3008898) HLA-B27 [Presence]

1.65

0.56

1.2

1.1

—

(36660697) Celiac disease serology panel - Serum

1.48

0.55

1.1

1.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.61

0.55

1.0

2.1

8.7

4.5

mg/l

—

(3045414) Leukocytes [Presence] in Urine

1.61

0.55

1.5

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

254

1.30

0.54

1.6

2.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

172

1.34

0.53

2.2

2.8

0.7

1.2

e6/l

0.87

107

(3004588) Protein electrophoresis panel - Serum or Plasma

1.44

0.53

4.2

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.53

0.52

3.8

2.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

229

1.29

0.50

1.6

1.3

2.8

2.5

g/l

0.18

132

(40761511) CBC panel - Blood by Automated count

111

1067

1.45

0.49

18.4

12.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

152

0.70

0.48

4.8

2.3

2.6

2.4

g/l

0.87

137

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

106

1013

1.35

0.47

17.5

13.6

17.4

21.1

mg/l

0.86

783

(3018095) Leukocytes [#/volume] in Urine

354

0.80

0.45

3.5

3.4

8.9

96.9

e6/l

2.25

262

(3052851) Hemolysis interference index of Serum or Plasma

1.64

0.43

1.6

4.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.59

0.43

1.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

911

1.25

0.41

24.5

15.2

40.0

39.8

0.06

675

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.41

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.41

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.41

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.41

0.40

10.7

4.2

111.2

82.6

ng/l

0.23

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

2.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.41

0.38

1.2

1.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

218

1.24

0.38

3.5

5.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

1.29

0.38

1.7

1.8

—

(40761535) Cells panel - Urine sediment

0.63

0.37

5.6

3.6

—

(21494755) Public health laboratory ask at order entry panel

0.61

0.36

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

146

1.27

0.34

1.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

262

1.19

0.30

2.5

3.6

297.4

981.9

ng/l

6.92

223

(3011397) Hemoglobin [Presence] in Urine by Test strip

224

1.20

0.30

5.0

3.1

—

(3002256) Pathology report gross observation

110

0.71

0.30

1.1

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

646

1.16

0.30

3.1

3.5

49.0

47.6

u/l

0.06

613

(4035726)

1.31

0.29

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

128

0.76

0.28

2.1

1.4

—

(4010399)

1.27

0.26

1.7

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

273

0.85

0.25

6.0

3.7

0.0

estimate

—

(3000991) Gas panel - Venous blood

0.70

0.25

14.2

9.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

593

1.13

0.23

13.9

9.3

3.9

4.1

e9/l

0.56

524

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.29

0.23

1.4

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

107

1.24

0.22

1.8

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

104

0.75

0.22

1.3

1.5

—

(3016879) Cocaine [Presence] in Urine

1.20

0.21

1.4

1.2

—

(3019225) pH of Specimen

1.26

0.21

2.6

5.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

2.8

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.3

—

92.2

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.21

0.0

1.4

—

510.8

—

(4281824)

0.00

0.21

0.0

1.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

203

1.16

0.21

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

4.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.24

0.20

2.6

2.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

175

0.84

0.20

2.2

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

142

0.83

0.18

4.4

2.4

12.8

23.8

—

125

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

927

0.89

0.18

12.5

12.9

83.9

83.8

ml/min/173m2

0.01

751

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.70

0.17

1.2

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

207

1.14

0.16

1.7

2.1

0.9

1.3

mg/l

0.61

161

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.12

0.16

3.4

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

118

0.83

0.15

7.7

7.2

—

(40768797) Stomach Pathology biopsy report

141

1.16

0.14

1.2

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

103

1.18

0.14

1.8

1.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.82

0.14

2.4

3.0

21.5

30.7

u/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

221

0.89

0.14

2.3

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

132

1.16

0.14

1.7

2.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

113

1.17

0.13

1.8

1.5

1.6

0.22

(3012544) pH of Venous blood

1.19

0.13

6.5

5.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

223

1.09

0.10

1.5

20.4

20.1

nmol/l

0.03

187

(3000764) Benzodiazepines [Presence] in Urine

1.09

0.09

1.4

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.09

0.09

3.8

3.9

0.9

1.0

—

(3027944) Amphetamines [Presence] in Urine

1.07

0.09

1.4

1.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.07

0.09

4.0

3.8

15.2

194.3

u/ml

—

(3027008) Opiates [Presence] in Urine

1.04

0.09

1.4

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.08

0.09

1.3

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.78

0.08

2.6

1.8

—

(40761536) Microorganisms panel - Urine sediment

0.82

0.07

4.7

3.5

—

(40768804) Tissue Pathology biopsy report

385

1.06

0.07

1.9

2.0

—

(36304419) Bacteria [Presence] in Urine

273

0.94

0.06

3.1

2.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

363

0.95

0.05

3.5

3.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

659

1.04

0.03

3.3

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

142

1.06

0.02

1.8

2.4

—

(3002385) Erythrocyte distribution width [Ratio]

868

0.97

0.02

24.5

16.9

13.4

13.6

1.12

853

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

203

1.04

0.01

4.1

3.0

0.8

ug/l

0.03

132

(3023368) Bacteria identified in Blood by Culture

247

0.96

0.01

4.1

4.3

—

(3003694) ABO and Rh group [Type] in Blood

303

0.99

0.00

1.3

1.6

—

(3013512) EKG study

264

0.98

0.00

3.9

4.1

—

(3009876) Amylase isoenzyme 3 panel - Serum or Plasma

0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.00

0.00

1.0

1.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

10.5

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.5

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

0.9

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

34.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

6.2

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.6

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

0.86

0.00

2.7

2.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.8

—

9.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

5.2

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.0

—

117.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.1

—

166.8

—

(3028300) Cannabinoids [Presence] in Urine

1.02

0.00

1.4

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.90

0.00

1.9

2.7

0.2

g/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.00

0.00

1.0

1.1

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

170

1.00

0.00

1.2

1.3

10.6

10.2

u/ml

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.1

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.4

—

(4211845)

0.00

0.0

1.7

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.7

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

3.2

—

221.6

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.86

0.00

1.8

3.5

—

63.7

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.8

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3003171) Aldosterone [Moles/volume] in Serum or Plasma --upright

0.00

0.0

1.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.3

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

13.5

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_MYRINGNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_MYRINGNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_MYRINGNAS – Other specified/unspecified disorders of tympanic membrane

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of tympanic membrane

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints