tympanic membrane disease: A disease involving the tympanic membrane.
Other specified/unspecified disorders of tympanic membrane
H8_MYRINGNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
134 |
4. Check minimum number of eventsNone |
134 |
5. Include endpointsNone |
134 |
6. Filter based on genotype QC (FinnGen only) |
128 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of tympanic membrane
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1266 | 625 | 640 |
| Only index persons | 1097 | 546 | 551 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 23.61 | 27.60 | 19.73 |
| Only index persons | 30.17 | 35.67 | 24.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 128 | 64 | 64 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 57.34 | 50.83 | 63.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 134
- Matched controls
- 1340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
97.0
81
*
UDC00
NOMESCO Finland
Ear microscopy
20.9
64.6
60
50
H73.9
ICD-10 Finland
Disorder of tympanic membrane, unspecified
+∞
55.1
49
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
16.9
46.3
45
39
DFF00
NOMESCO Finland
Pure tone audiometry
11.9
39.5
50
64
Z01.1
ICD-10 Finland
Examination of ears and hearing
10.1
37.2
56
89
H66.9
ICD-10 Finland
Otitis media, unspecified
15.3
32.9
32
27
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
32.6
30
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
117.0
26.8
28
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
304.5
25.6
25
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
22.5
21
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
22.5
21
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
7.9
18.8
29
45
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
48.3
14.5
17
*
DC1AD
NOMESCO Finland
Temporalbone CT
83.5
13.9
15
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
12.7
12
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
71.4
11.8
13
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
10.6
10
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
10.6
10
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
35.7
10.5
13
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.0
10.2
35
109
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
43.6
10.1
12
*
H73.0
ICD-10 Finland
Acute myringitis
59.4
9.8
11
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
9.5
9
*
H60.3
ICD-10 Finland
Other infective otitis externa
13.9
9.1
15
12
R01AD08
ATC
fluticasone; nasal
3.0
8.4
52
232
4122
FHL
Tympanostomy (tympanic tube)
+∞
8.4
8
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
8.4
8
*
DFF15
NOMESCO Finland
Speech audiometry
8.1
8.3
18
25
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.2
8.1
18
39
H60.8
ICD-10 Finland
Other otitis externa
10.3
7.5
14
15
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.8
7.4
86
526
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
7.4
7
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
7.4
7
*
H65.0
ICD-10 Finland
Acute serous otitis media
31.9
7.2
9
*
WX720
NOMESCO Finland
Own respiration
7.4
7.1
16
24
H01
ICPC
Ear pain/earache
3.6
6.9
26
85
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
73.2
6.5
7
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
6.3
6
*
3848X
ICD-9 Finland
Other disorders of tympanic membrane, Other specified disorders of tympanic membrane
+∞
6.3
6
*
H04
ICPC
Ear discharge
10.8
6.2
11
11
WX400
NOMESCO Finland
Inhalation anesthesy
7.9
6.1
13
18
Z97.4
ICD-10 Finland
Presence of external hearing-aid
7.0
6.0
14
22
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
188
2.34
4.28
4.9
3.9
562.61
228.57
ng/l
0.41
28
142
44
242
2.22
4.22
5.1
3.6
1.02
1.02
kg/l
—
10
33
52
311
2.10
4.00
4.3
3.9
2.96
14.41
mg/mmol
2.46
37
201
70
492
1.89
3.23
14.0
12.8
1.38
1.22
inr
0.60
20
145
70
512
1.77
2.68
12.2
6.9
1.21
1.21
mmol/l
0.10
63
446
23
118
2.15
2.54
8.5
7.1
1.18
1.32
mmol/l
0.11
18
95
99
816
1.82
2.37
5.9
4.0
14.44
14.69
pmol/l
0.51
92
731
50
343
1.73
2.32
5.6
3.3
2.32
2.36
mmol/l
1.36
44
296
21
116
1.96
1.92
9.4
7.1
12.13
12.80
kpa
0.34
21
111
21
116
1.96
1.92
9.3
7.2
5.13
5.06
kpa
0.22
21
111
44
307
1.65
1.86
2.0
2.2
108.79
370.69
u/l
0.69
39
294
80
649
1.58
1.78
6.8
4.5
6.85
6.78
mmol/l
0.09
75
593
5
13
3.95
1.73
1.0
1.1
—
—
—
0
0
97
830
1.61
1.66
4.6
4.1
9.90
11.08
mm/h
0.47
92
763
54
408
1.54
1.61
1.8
1.9
96.00
95.51
pmol/l
0.03
28
213
125
1166
2.07
1.42
19.4
15.8
81.01
76.90
umol/l
0.37
125
1166
52
400
1.49
1.39
2.8
3.8
35.11
40.91
ng/l
0.11
32
272
28
188
1.62
1.36
1.1
1.3
10.13
29.78
iu/ml
—
10
65
44
329
1.50
1.34
5.5
4.6
19.61
21.04
%
0.23
19
161
13
69
1.98
1.34
1.5
1.5
—
—
—
0
0
0
41
0.00
1.33
0.0
1.7
—
—
—
0
0
55
434
1.45
1.27
5.1
3.7
—
—
—
0
0
8
37
2.23
1.24
1.3
2.1
—
—
—
0
0
110
997
1.58
1.20
6.5
5.6
39.42
39.62
mmol/mol
0.09
102
936
5
20
2.56
1.16
4.8
9.5
—
679.50
—
0
6
24
163
1.58
1.11
1.5
1.4
—
—
—
0
0
5
21
2.43
1.10
1.2
2.1
24.46
25.11
mmol/l
—
5
21
7
32
2.25
1.10
1.4
1.6
—
0.01
—
0
8
63
522
1.39
1.07
2.3
2.7
—
—
—
0
0
24
165
1.55
1.06
2.0
2.1
27.27
29.81
s
2.32
24
160
7
35
2.05
1.01
1.1
1.7
—
—
—
0
0
113
1043
1.53
0.99
5.2
4.5
5.93
5.92
mmol/l
0.05
105
965
66
557
1.36
0.98
4.6
3.6
0.00
0.00
estimate
—
7
105
65
551
1.35
0.93
4.7
3.5
0.00
0.00
estimate
—
8
121
124
1175
1.74
0.89
12.8
10.4
30.61
25.77
u/l
0.72
119
1143
11
173
0.60
0.82
5.0
2.2
10.05
14.05
umol/l
1.74
11
160
22
158
1.47
0.81
1.7
1.8
—
—
—
0
0
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
64
551
1.31
0.79
7.2
4.9
0.00
0.00
estimate
—
8
113
0
27
0.00
0.78
0.0
2.6
—
112.48
—
0
15
24
178
1.42
0.75
2.5
2.8
2.94
2.47
e6/l
0.12
16
106
5
24
2.12
0.75
1.0
1.5
—
—
—
0
0
5
27
1.88
0.69
1.2
1.3
—
—
—
0
0
24
182
1.39
0.67
2.1
1.7
940.23
1166.08
nmol/l
0.73
19
143
25
191
1.38
0.67
2.3
2.7
0.74
1.11
e6/l
0.79
17
118
11
164
0.64
0.66
4.8
2.2
2.60
2.34
g/l
0.96
11
148
29
229
1.34
0.64
1.6
1.8
0.79
1.28
mg/l
0.95
23
177
16
114
1.46
0.62
1.7
1.7
—
—
—
0
0
18
135
1.39
0.54
7.7
7.0
103.67
103.26
mmol/l
0.17
18
135
6
40
1.52
0.52
1.2
1.4
—
—
—
0
0
6
40
1.52
0.52
3.8
2.3
—
—
—
0
0
15
110
1.41
0.51
1.6
1.6
—
—
—
0
0
17
128
1.38
0.50
1.6
1.7
1.45
1.52
%
0.21
17
109
117
1124
1.32
0.44
16.5
13.2
17.79
21.48
mg/l
0.85
98
868
5
32
1.58
0.42
1.2
1.2
—
—
—
0
0
8
59
1.38
0.42
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
33
283
1.22
0.39
1.6
2.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
26
218
1.24
0.38
1.8
1.7
357143269.67
462.01
pmol/l
0.48
21
184
5
79
0.62
0.36
1.4
1.6
—
—
—
0
0
5
79
0.62
0.36
1.2
1.3
—
—
—
0
0
6
41
1.48
0.36
1.2
1.8
—
—
—
0
0
12
154
0.76
0.34
4.4
2.3
12.80
24.47
%
—
6
136
104
999
1.18
0.30
21.2
16.0
15.60
14.80
%
0.52
104
986
26
299
0.84
0.30
5.7
3.6
0.00
0.00
estimate
—
8
107
8
62
1.31
0.28
1.4
1.4
—
—
—
0
0
28
245
1.18
0.27
1.4
1.5
20.20
20.50
nmol/l
0.04
21
209
11
86
1.30
0.27
10.7
4.0
111.18
80.41
ng/l
0.25
11
79
5
39
1.29
0.23
1.0
1.3
—
—
—
0
0
8
105
0.75
0.22
2.4
2.9
21.50
31.16
u/l
—
8
89
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
42.14
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
6
50
1.21
0.20
3.3
2.9
0.87
1.19
%
—
6
50
26
234
1.14
0.18
1.5
1.5
—
—
—
0
0
76
729
1.10
0.17
3.1
3.4
50.41
46.96
u/l
0.18
70
694
17
151
1.14
0.14
1.7
2.2
—
—
—
0
0
20
180
1.13
0.14
1.2
1.3
9.58
9.36
u/ml
—
8
76
68
654
1.08
0.13
13.0
8.9
3.89
4.11
e9/l
0.52
63
577
101
1030
0.92
0.11
11.9
12.7
83.70
84.11
ml/min/173m2
0.06
79
834
75
732
1.06
0.08
3.2
2.9
—
—
—
0
0
6
73
0.81
0.08
2.8
1.8
—
—
—
0
0
12
108
1.12
0.07
2.6
3.1
—
—
—
0
0
9
85
1.06
0.07
3.6
1.9
—
—
—
0
0
30
313
0.95
0.05
3.0
2.9
0.18
0.52
e6/l
0.84
25
241
17
161
1.06
0.03
1.9
2.4
—
—
—
0
0
39
397
0.98
0.01
3.4
3.0
—
—
—
0
0
12
126
0.95
0.00
7.8
7.0
—
—
—
0
0
24
243
0.98
0.00
3.7
3.0
0.79
0.76
ug/l
0.07
16
159
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
221.60
—
0
5
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
14.33
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
13.50
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
166.81
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
4.0
3.8
15.20
182.20
u/ml
—
5
45
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MYRINGNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_MYRINGNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_MYRINGNAS – Other specified/unspecified disorders of tympanic membrane
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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