thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
136 |
Control definitions (FinnGen only)
- Control exclude
- I9_DOAAC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I73
- Name in latin
- Tromboangi(i)tis obliterans (Bürger)
Similar endpoints
↥List of similar endpoints to
Thromboangiitis obliterans
based on the number of shared cases.
Similar with more cases:
- Other peripheral vascular diseases
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1319 | 389 | 900 |
| Only index persons | 869 | 322 | 547 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.03 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.80 | 53.06 | 52.44 |
| Only index persons | 51.00 | 51.70 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 136 | 49 | 87 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 49.49 | 46.58 | 51.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 120
- Matched controls
- 1198
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
102.2
83
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
210.9
51.5
50
*
44310
ICD-8 Finland
Other peripheral vascular disease, Thrombo-angiitis obliterans (Buerger's disease)
+∞
35.1
32
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
32.8
23.1
30
12
4431A
ICD-9 Finland
Other peripheral vascular disease, Thromboangiitis obliterans [Buerger's disease]
+∞
21.5
20
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
+∞
13.8
13
*
C08CA05
ATC
nifedipine; systemic
7.6
12.4
30
50
2424
FHL
Sympatectomy, lumbar
+∞
10.6
10
*
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
60.0
9.8
11
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
+∞
8.4
8
*
I71.3
ICD-10 Finland
Abdominal aortic aneurysm, ruptured
+∞
8.4
8
*
I73.0
ICD-10 Finland
Raynaud syndrome
36.0
8.2
10
*
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
+∞
7.4
7
*
I73.9
ICD-10 Finland
Peripheral vascular disease, unspecified
+∞
7.4
7
*
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
7.4
7
*
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
+∞
7.4
7
*
9571
FHL
Amputation of toe or toes
+∞
7.4
7
*
J01FF01
ATC
clindamycin; systemic
3.2
6.8
41
168
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.2
6.6
14
19
9573
FHL
Leg amputation
+∞
6.3
6
*
2423
FHL
Sympatectomy, thoracic
+∞
6.3
6
*
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 2.288 [1.72, 3.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.357 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 1.982 [1.58, 2.48] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.265% | 0.289% |
| 5 | 1.479% | 2.21% |
| 10 | 3.389% | 5.427% |
| 15 | 6.828% | 9.841% |
| 20 | 11.912% | 16.326% |
Relationships between endpoints
↥Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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