thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
- Control exclude
- I9_DOAAC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I73
- Name in latin
- Tromboangi(i)tis obliterans (Bürger)
Similar endpoints
↥List of similar endpoints to
Thromboangiitis obliterans
based on the number of shared cases.
Similar with more cases:
- Other peripheral vascular diseases
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1319 | 389 | 900 |
| Only index persons | 869 | 322 | 547 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.03 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.80 | 53.06 | 52.44 |
| Only index persons | 51.00 | 51.70 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | 48 | 86 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 49.36 | 46.15 | 51.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 136
- Matched controls
- 1360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
118.8
96
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
155.6
61.1
61
7
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
21.3
41.5
34
21
44310
ICD-8 Finland
Other peripheral vascular disease, Thrombo-angiitis obliterans (Buerger's disease)
+∞
36.1
33
*
C08CA05
ATC
nifedipine; systemic
10.0
27.8
37
49
4431A
ICD-9 Finland
Other peripheral vascular disease, Thromboangiitis obliterans [Buerger's disease]
+∞
24.7
23
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
+∞
14.9
14
*
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
+∞
12.7
12
*
I73.0
ICD-10 Finland
Raynaud syndrome
47.5
11.1
13
*
2424
FHL
Sympatectomy, lumbar
+∞
10.5
10
*
I73.9
ICD-10 Finland
Peripheral vascular disease, unspecified
107.2
9.5
10
*
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
+∞
9.5
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
10.6
9.1
17
18
C08CA02
ATC
felodipine; oral
4.0
8.5
27
79
I71.3
ICD-10 Finland
Abdominal aortic aneurysm, ruptured
+∞
8.4
8
*
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
+∞
8.4
8
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
15.8
8.4
13
9
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
47.8
7.8
9
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
84.5
7.5
8
*
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
7.4
7
*
2423
FHL
Sympatectomy, thoracic
+∞
7.4
7
*
9571
FHL
Amputation of toe or toes
+∞
7.4
7
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
7.4
7
*
J01FF01
ATC
clindamycin; systemic
2.8
7.1
49
229
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
+∞
6.3
6
*
PD4AD
NOMESCO Finland
CT of lower extremity arteries
+∞
6.3
6
*
9573
FHL
Leg amputation
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
18
7.86
6.09
1.4
1.6
—
—
—
0
0
12
26
4.96
4.17
1.6
1.6
—
—
—
0
0
35
181
2.26
3.85
5.4
3.3
347.88
86.14
ng/l
0.52
26
148
11
24
4.89
3.84
1.4
1.4
72.80
17.82
u/ml
—
5
5
63
429
1.87
3.17
3.4
2.6
—
—
—
0
0
71
503
1.86
3.15
23.0
16.7
1.43
1.33
inr
0.30
28
150
20
89
2.46
3.04
3.0
3.8
3.27
2.13
mmol/l
0.44
14
70
42
261
1.88
2.75
2.5
2.0
5.75
3.02
mg/l
1.60
37
216
28
154
2.03
2.59
3.4
2.2
2.54
2.29
g/l
1.05
28
131
67
488
1.74
2.55
4.2
3.6
0.00
0.00
estimate
-0.00
16
80
66
484
1.71
2.42
5.6
5.1
0.00
0.00
estimate
-0.00
17
87
66
487
1.69
2.34
4.2
3.6
0.00
0.00
estimate
-0.00
19
97
6
13
4.77
2.29
2.0
1.3
21.08
15.01
ug/l
—
6
13
67
499
1.68
2.28
8.0
6.7
1.21
1.21
mmol/l
0.13
56
418
54
385
1.67
2.14
2.8
2.2
79.05
78.29
nmol/l
0.05
48
334
19
102
2.00
1.87
4.2
3.5
—
—
—
0
0
39
265
1.66
1.82
4.3
3.8
0.00
0.00
estimate
-0.00
16
82
7
24
3.02
1.74
1.3
1.3
—
—
—
0
0
16
83
2.05
1.73
1.5
3.1
63.08
66.63
g/l
1.11
16
71
41
287
1.61
1.69
4.7
2.8
1.14
0.31
e6/l
0.39
33
209
35
236
1.65
1.67
3.4
2.1
—
—
—
0
0
50
369
1.56
1.65
4.8
2.9
—
—
—
0
0
11
51
2.26
1.55
2.3
2.5
1.46
1.28
%
0.27
11
51
6
21
2.94
1.52
1.0
1.7
—
—
—
0
0
11
53
2.17
1.43
10.3
4.1
24.41
24.61
mmol/l
0.04
11
53
19
113
1.79
1.41
2.3
1.6
—
—
—
0
0
13
68
2.01
1.38
1.3
1.5
—
—
—
0
0
51
393
1.48
1.34
4.3
3.8
—
—
—
0
0
20
123
1.73
1.33
8.1
6.1
1.02
1.02
mmol/l
0.02
20
111
35
250
1.54
1.31
2.1
1.6
15.48
21.24
nmol/l
1.30
28
206
71
587
1.44
1.28
12.2
9.0
4.88
4.25
e9/l
1.08
61
512
10
49
2.12
1.25
1.9
2.5
0.64
0.68
%
—
10
49
26
176
1.59
1.22
2.5
1.7
—
—
—
0
0
5
20
2.55
1.16
1.2
1.6
—
—
—
0
0
5
20
2.55
1.16
1.2
1.6
—
—
—
0
0
79
898
0.71
1.11
4.6
4.4
2.04
1.94
mu/l
0.20
71
800
23
155
1.58
1.10
4.7
2.6
1.07
1.47
e6/l
0.25
14
87
7
32
2.25
1.10
2.9
3.3
—
—
—
0
0
11
61
1.87
1.02
1.9
1.6
—
—
—
0
0
56
462
1.36
0.95
7.3
6.0
1.20
1.21
mmol/l
0.35
51
413
88
970
0.74
0.89
4.5
4.8
5.99
5.94
mmol/l
0.17
79
876
83
921
0.75
0.86
6.4
5.8
40.73
39.95
mmol/mol
0.32
75
846
10
57
1.81
0.86
1.2
1.4
—
—
—
0
0
11
65
1.75
0.85
3.6
2.6
0.04
0.14
e6/l
1.60
11
65
17
114
1.56
0.84
2.5
1.7
—
—
—
0
0
5
23
2.22
0.77
1.8
1.3
—
—
—
0
0
17
118
1.50
0.73
3.2
3.5
254.88
235.44
u/l
0.66
17
111
29
225
1.37
0.71
1.8
1.8
350.73
464.28
pmol/l
1.77
22
188
7
42
1.70
0.69
1.0
3.0
2.76
3.00
g/l
—
7
35
7
42
1.70
0.69
2.1
2.0
28.71
37.99
u/l
—
7
37
18
129
1.46
0.67
10.8
8.8
5.20
5.05
kpa
0.18
18
123
18
129
1.46
0.67
10.8
8.8
10.03
11.62
kpa
1.32
18
123
7
44
1.62
0.66
1.0
2.9
6.77
7.54
g/l
—
7
37
7
44
1.62
0.66
1.0
2.9
3.10
3.51
g/l
—
7
37
7
44
1.62
0.66
1.0
2.9
—
—
—
0
0
18
130
1.44
0.65
2.1
4.9
3.01
43.67
ug/l
0.71
18
112
51
442
1.25
0.56
5.9
3.8
44.10
44.01
ng/l
0.00
43
338
9
131
0.67
0.55
1.7
1.5
—
—
—
0
0
21
164
1.33
0.50
4.0
2.5
0.43
0.98
e6/l
0.97
12
96
7
48
1.48
0.47
3.1
1.6
—
—
—
0
0
7
49
1.45
0.46
3.3
1.7
—
—
—
0
0
86
801
1.20
0.43
30.7
18.0
16.39
15.39
%
0.71
86
789
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
6
41
1.48
0.36
1.0
3.0
9.43
10.24
g/l
—
6
33
67
718
0.87
0.31
3.5
3.7
15.49
14.89
pmol/l
0.94
59
642
95
993
0.86
0.31
4.9
5.1
2.47
2.64
mmol/l
0.91
87
898
9
118
0.75
0.29
1.6
1.4
—
—
—
0
0
88
922
0.87
0.28
24.9
14.0
79.14
76.79
ml/min/173m2
0.38
75
747
35
315
1.15
0.24
4.7
3.5
15.88
6.52
mg/mmol
0.60
26
193
23
262
0.85
0.24
2.7
3.1
0.74
0.81
ug/l
0.14
13
185
92
956
0.88
0.23
4.6
4.6
1.33
1.45
mmol/l
1.86
84
866
17
198
0.84
0.22
1.3
1.1
0.30
1.59
u/ml
—
5
51
93
964
0.89
0.22
4.7
4.6
4.28
4.51
mmol/l
1.20
85
880
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
45
417
1.12
0.20
2.5
2.0
96.14
94.72
pmol/l
0.06
33
208
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
0.48
—
0
9
34
367
0.90
0.16
3.9
4.3
23.46
21.76
%
0.17
12
195
23
212
1.10
0.11
2.1
1.8
1142.62
1213.91
nmol/l
0.15
17
159
77
748
1.07
0.10
6.7
4.0
15.56
14.02
mm/h
0.30
71
678
105
1068
0.93
0.09
40.3
22.1
38.49
39.84
%
0.87
93
1011
92
933
0.96
0.05
4.2
4.1
1.27
1.23
mmol/l
0.35
85
841
45
463
0.96
0.05
4.0
5.1
2.67
3.18
ug/l
0.21
39
401
55
543
1.02
0.01
3.0
2.8
—
—
—
0
0
98
974
1.02
0.00
30.3
15.1
32.18
26.15
mg/l
0.85
93
783
13
135
0.96
0.00
15.2
7.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
14
140
1.00
-0.00
1.3
1.3
25.78
6.55
u/ml
—
6
46
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
995.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 2.288 [1.72, 3.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.357 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 1.982 [1.58, 2.48] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.265% | 0.289% |
| 5 | 1.479% | 2.21% |
| 10 | 3.389% | 5.427% |
| 15 | 6.828% | 9.841% |
| 20 | 11.912% | 16.326% |
Relationships between endpoints
↥Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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