thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
136 |
Control definitions (FinnGen only)
- Control exclude
- I9_DOAAC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I73
- Name in latin
- Tromboangi(i)tis obliterans (Bürger)
Similar endpoints
↥List of similar endpoints to
Thromboangiitis obliterans
based on the number of shared cases.
Similar with more cases:
- Other peripheral vascular diseases
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1319 | 389 | 900 |
| Only index persons | 869 | 322 | 547 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.03 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.80 | 53.06 | 52.44 |
| Only index persons | 51.00 | 51.70 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 136 | 49 | 87 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 49.49 | 46.58 | 51.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 120
- Matched controls
- 1198
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
102.2
83
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
210.9
51.5
50
*
44310
ICD-8 Finland
Other peripheral vascular disease, Thrombo-angiitis obliterans (Buerger's disease)
+∞
35.1
32
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
32.8
23.1
30
12
4431A
ICD-9 Finland
Other peripheral vascular disease, Thromboangiitis obliterans [Buerger's disease]
+∞
21.5
20
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
+∞
13.8
13
*
C08CA05
ATC
nifedipine; systemic
7.6
12.4
30
50
2424
FHL
Sympatectomy, lumbar
+∞
10.6
10
*
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
60.0
9.8
11
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
+∞
8.4
8
*
I71.3
ICD-10 Finland
Abdominal aortic aneurysm, ruptured
+∞
8.4
8
*
I73.0
ICD-10 Finland
Raynaud syndrome
36.0
8.2
10
*
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
+∞
7.4
7
*
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
7.4
7
*
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
+∞
7.4
7
*
9571
FHL
Amputation of toe or toes
+∞
7.4
7
*
I73.9
ICD-10 Finland
Peripheral vascular disease, unspecified
+∞
7.4
7
*
J01FF01
ATC
clindamycin; systemic
3.2
6.8
41
168
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.2
6.6
14
19
9573
FHL
Leg amputation
+∞
6.3
6
*
2423
FHL
Sympatectomy, thoracic
+∞
6.3
6
*
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
18
7.88
9.01
1.4
1.6
—
—
—
0
0
12
26
4.97
5.37
1.7
1.6
—
—
—
0
0
11
24
4.90
4.87
1.4
1.4
72.8
17.8
u/ml
—
5
5
35
181
2.26
3.85
5.4
3.3
347.9
83.9
ng/l
0.53
26
148
63
430
1.87
3.14
5.1
4.2
—
—
—
0
0
20
90
2.43
2.97
3.1
3.8
3.3
2.2
mmol/l
0.40
13
70
42
265
1.85
2.61
2.5
2.0
5.8
3.0
mg/l
1.60
37
218
67
491
1.72
2.47
4.2
3.6
0.0
0.0
estimate
0.00
16
81
28
158
1.97
2.41
3.4
2.2
2.5
2.3
g/l
0.99
28
136
66
487
1.69
2.34
4.0
3.5
0.0
0.0
estimate
0.00
16
91
66
487
1.69
2.34
5.6
5.0
0.0
0.0
estimate
0.00
17
88
6
13
4.77
2.29
2.0
1.3
21.1
15.0
ug/l
—
6
13
67
500
1.67
2.25
8.0
6.8
1.2
1.2
mmol/l
0.13
56
414
54
386
1.66
2.11
2.8
2.2
79.0
78.0
nmol/l
0.08
48
335
19
104
1.96
1.78
4.2
3.5
—
—
—
0
0
39
267
1.65
1.76
4.3
3.8
0.0
0.0
estimate
0.00
16
83
7
24
3.02
1.74
1.3
1.3
—
—
—
0
0
41
286
1.62
1.72
4.7
2.7
1.2
0.3
e6/l
0.39
32
208
35
235
1.66
1.70
3.4
2.1
—
—
—
0
0
50
370
1.56
1.63
4.8
2.9
—
—
—
0
0
22
133
1.78
1.54
9.0
4.9
103.0
103.8
mmol/l
0.29
22
127
11
52
2.21
1.49
2.3
2.5
1.5
1.3
%
0.26
11
52
6
22
2.80
1.45
1.0
1.7
—
—
—
0
0
11
53
2.17
1.43
10.3
4.1
24.4
24.6
mmol/l
0.04
11
53
13
68
2.01
1.38
1.3
1.5
—
—
—
0
0
19
115
1.76
1.33
2.3
1.6
—
—
—
0
0
51
394
1.47
1.32
4.3
3.8
—
—
—
0
0
20
125
1.70
1.26
8.1
6.1
1.0
1.0
mmol/l
0.08
20
113
35
253
1.52
1.24
2.1
1.6
15.5
21.4
nmol/l
1.34
28
209
71
591
1.42
1.21
12.2
9.1
4.9
4.3
e9/l
0.95
61
515
5
20
2.55
1.16
1.2
1.6
—
—
—
0
0
5
20
2.55
1.16
1.2
1.6
—
—
—
0
0
79
900
0.71
1.14
4.6
4.4
2.0
1.9
mu/l
0.20
71
801
23
154
1.59
1.13
4.7
2.5
1.1
1.4
e6/l
0.21
14
85
26
180
1.55
1.11
2.5
1.7
—
—
—
0
0
7
32
2.25
1.10
2.9
3.3
—
—
—
0
0
56
463
1.36
0.94
7.3
6.1
1.2
1.2
mmol/l
0.41
51
411
11
63
1.81
0.93
1.9
1.7
—
—
—
0
0
88
971
0.73
0.91
4.5
4.8
6.0
5.9
mmol/l
0.15
79
876
10
56
1.85
0.90
1.2
1.4
—
—
—
0
0
83
923
0.74
0.89
6.4
5.9
40.7
40.0
mmol/mol
0.28
75
845
11
65
1.75
0.85
3.6
2.6
0.0
0.1
e6/l
1.56
11
65
17
116
1.53
0.79
2.5
1.7
—
—
—
0
0
5
23
2.22
0.77
1.8
1.3
—
—
—
0
0
7
43
1.66
0.68
2.1
1.9
28.7
39.3
u/l
—
7
38
18
129
1.46
0.67
2.1
4.9
3.0
44.1
ug/l
0.71
18
111
29
227
1.35
0.67
1.8
1.8
350.7
459.4
pmol/l
1.67
22
191
7
44
1.62
0.66
1.0
2.9
—
—
—
0
0
18
130
1.44
0.65
10.8
8.7
10.0
11.5
kpa
1.24
18
124
18
130
1.44
0.65
10.8
8.7
5.2
5.0
kpa
0.21
18
124
17
124
1.42
0.59
3.2
3.5
254.9
237.2
u/l
0.59
17
117
51
445
1.23
0.52
5.9
3.9
44.1
44.0
ng/l
0.00
43
339
21
163
1.34
0.52
4.0
2.4
0.4
1.0
e6/l
0.98
12
94
7
49
1.45
0.46
3.1
1.7
—
—
—
0
0
9
129
0.68
0.46
1.7
1.5
—
—
—
0
0
7
50
1.42
0.46
3.3
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
67
719
0.87
0.32
3.5
3.7
15.5
14.9
pmol/l
0.94
59
643
95
994
0.85
0.32
4.9
5.1
2.5
2.6
mmol/l
0.85
87
898
7
53
1.34
0.31
14.3
6.5
25.1
24.7
mmol/l
—
7
48
9
117
0.75
0.29
1.6
1.4
—
—
—
0
0
88
918
0.88
0.24
24.9
14.2
79.5
76.6
ml/min/173m2
0.49
74
740
92
957
0.88
0.24
4.6
4.6
1.3
1.5
mmol/l
1.85
84
866
23
261
0.86
0.23
2.7
3.1
0.7
0.8
ug/l
0.16
13
185
93
965
0.89
0.22
4.7
4.6
4.3
4.5
mmol/l
1.16
85
880
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
0.6
—
0
7
17
195
0.85
0.19
1.3
1.1
0.3
1.6
u/ml
—
5
50
45
420
1.11
0.18
2.5
2.0
96.1
94.9
pmol/l
0.05
33
213
34
366
0.91
0.15
3.9
4.3
23.5
21.8
%
0.17
12
195
23
212
1.10
0.11
2.1
1.8
1142.6
1212.4
nmol/l
0.14
17
159
77
749
1.06
0.10
6.7
4.0
15.6
14.0
mm/h
0.31
71
678
45
464
0.95
0.05
4.0
5.0
2.7
3.2
ug/l
0.21
39
401
92
933
0.96
0.05
4.2
4.1
1.3
1.2
mmol/l
0.36
85
840
13
136
0.95
0.00
15.2
7.7
—
—
—
0
0
98
975
1.02
0.00
30.3
15.2
32.2
26.0
mg/l
0.89
93
784
55
546
1.01
0.00
3.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
14
140
1.00
0.00
1.3
1.3
25.8
6.6
u/ml
—
6
46
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
995.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
4.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 2.288 [1.72, 3.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.357 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 1.982 [1.58, 2.48] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.265% | 0.289% |
| 5 | 1.479% | 2.21% |
| 10 | 3.389% | 5.427% |
| 15 | 6.828% | 9.841% |
| 20 | 11.912% | 16.326% |
Relationships between endpoints
↥Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data