skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Other infiltrative disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_OTHERINFILTRATIVESKIN
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
169 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L98
- Name in latin
- Aliae morbositates infiltrativae cutis et textus subcutanei
Similar endpoints
↥List of similar endpoints to
Other infiltrative disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1124 | 634 | 485 |
| Only index persons | 1034 | 597 | 437 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.18 | 56.99 | 52.63 |
| Only index persons | 55.43 | 57.00 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 169 | 104 | 65 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | 56.69 | 55.95 | 57.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L98.6
ICD-10 Finland
Other infiltrative disorders of skin and subcutaneous tissue
+∞
88.2
77
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
19.6
77.3
73
62
L98.69
ICD-10 Finland
Other infiltrative disease of the skin and subcutaneous tissue
+∞
54.0
49
*
L98.60
ICD-10 Finland
Pseudolymphoma of the skin
+∞
29.0
27
*
L98.64
ICD-10 Finland
Benign lymphocyte infiltration into the skin [Jessner-Kanof]
+∞
20.2
19
*
L98.63
ICD-10 Finland
Lymphocytoma of the skin
+∞
18.0
17
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
16.2
59
193
D07AC01
ATC
betamethasone; topical
3.3
13.8
89
416
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.3
13.4
30
66
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
6.0
13.2
25
47
L93.0
ICD-10 Finland
Discoid lupus erythematosus
139.7
12.6
13
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
19.9
12.3
18
10
D07AD01
ATC
clobetasol; topical
3.7
12.1
48
164
D07AC13
ATC
mometasone; topical
3.0
10.5
68
309
D07AB08
ATC
desonide; topical
3.6
8.6
32
103
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
21.3
8.6
12
6
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.1
7.9
23
62
L93.2
ICD-10 Finland
Other local lupus erythematosus
+∞
7.3
7
*
P01BA02
ATC
hydroxychloroquine; oral
3.6
7.3
26
81
S18
ICPC
Laceration/cut
2.4
7.2
91
550
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
31.4
7.2
9
*
E0000UV, ,
ATC
2.3
7.0
83
487
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
72.4
6.5
7
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
5.5
6.4
18
36
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
821
2.18
5.54
11.0
10.0
3.69
4.00
e9/l
1.01
104
724
16
37
4.65
5.09
1.9
2.2
—
—
—
0
0
42
216
2.24
4.58
2.1
1.8
—
—
—
0
0
31
147
2.35
4.05
1.8
1.7
—
—
—
0
0
31
152
2.26
3.75
2.0
1.8
—
—
—
0
0
46
271
1.95
3.44
4.5
3.6
267.74
157.37
ng/l
0.33
35
205
92
674
1.77
3.41
8.4
6.5
1.22
1.21
mmol/l
0.19
82
581
6
7
8.82
3.29
1.5
2.1
—
—
—
0
0
130
1063
1.88
3.26
5.6
4.1
10.57
12.22
mm/h
1.06
124
974
18
74
2.60
3.17
1.4
1.7
—
—
—
0
0
20
89
2.41
3.00
1.5
1.3
—
—
—
0
0
36
208
1.92
2.82
2.6
1.9
29.33
29.59
s
0.13
36
203
55
368
1.72
2.68
3.2
2.9
6865.65
10404.72
umol/l
0.20
49
309
31
175
1.94
2.60
11.2
6.0
103.48
104.05
mmol/l
0.25
31
175
47
306
1.73
2.50
2.4
1.8
1.35
1.19
mg/l
0.16
40
238
5
9
5.68
2.23
5.6
1.9
14.20
13.33
%
—
5
9
9
30
3.11
2.18
1.0
1.3
—
—
—
0
0
10
38
2.73
2.04
1.0
1.1
—
—
—
0
0
55
392
1.59
2.04
3.8
2.8
0.14
0.35
e6/l
1.65
42
291
5
11
4.64
1.95
1.4
1.2
—
—
—
0
0
7
22
3.27
1.90
1.7
1.9
—
—
—
0
0
7
22
3.27
1.90
1.7
1.9
—
—
—
0
0
13
59
2.30
1.89
2.3
2.3
—
—
—
0
0
6
17
3.62
1.85
1.8
1.5
—
—
—
0
0
5
12
4.26
1.83
1.4
1.1
—
—
—
0
0
9
35
2.66
1.83
1.4
1.3
—
—
—
0
0
11
47
2.43
1.81
2.6
2.1
—
—
—
0
0
82
654
1.48
1.77
11.3
12.2
1.20
1.26
inr
0.25
29
184
9
36
2.58
1.76
1.4
1.6
—
—
—
0
0
7
24
2.99
1.74
6.7
3.1
52.14
56.96
%
—
7
24
20
112
1.89
1.73
4.7
3.1
61.38
64.29
ml/min/173m2
—
8
49
5
13
3.93
1.72
1.8
2.3
—
—
—
0
0
5
13
3.93
1.72
1.8
2.3
—
—
—
0
0
5
13
3.93
1.72
1.8
2.3
—
—
—
0
0
65
499
1.48
1.68
3.9
2.8
—
—
—
0
0
79
631
1.46
1.67
7.0
5.7
1.21
1.21
mmol/l
0.12
72
577
5
14
3.64
1.62
1.2
1.4
—
—
—
0
0
35
237
1.60
1.58
2.3
2.5
0.52
1.05
e6/l
1.23
19
134
29
188
1.65
1.56
2.1
2.1
24.07
22.12
%
0.33
23
161
5
15
3.40
1.53
1.0
1.4
—
—
—
0
0
43
308
1.53
1.53
1.3
1.2
1.11
0.89
u/ml
0.15
13
88
6
21
2.92
1.52
1.5
1.4
—
—
—
0
0
85
698
1.43
1.51
4.1
3.6
0.00
0.01
estimate
0.50
16
137
85
698
1.43
1.51
5.4
4.9
0.00
0.00
estimate
-0.00
13
130
10
45
2.30
1.49
1.0
1.2
—
—
—
0
0
5
16
3.18
1.45
2.0
2.1
—
—
—
0
0
5
16
3.18
1.45
1.2
1.2
—
—
—
0
0
6
22
2.79
1.44
1.7
1.3
—
—
—
0
0
10
46
2.25
1.43
2.7
2.7
0.00
0.11
g/l
—
10
46
9
41
2.26
1.39
1.8
1.4
—
—
—
0
0
6
23
2.66
1.38
2.0
1.6
—
—
—
0
0
73
591
1.41
1.37
3.2
2.6
150.43
115.32
ug/l
0.63
67
541
6
24
2.55
1.31
1.3
1.2
—
—
—
0
0
35
248
1.51
1.31
1.2
1.3
45.27
42.73
iu/ml
0.03
13
81
102
881
1.38
1.27
3.1
3.0
—
—
—
0
0
6
25
2.45
1.25
1.3
1.2
3.77
3.55
mmol/l
—
6
19
6
25
2.45
1.25
1.8
1.8
—
—
—
0
0
84
707
1.36
1.21
4.1
3.7
0.00
0.00
estimate
-0.00
12
129
71
582
1.37
1.21
2.4
2.1
80.44
75.70
nmol/l
0.83
63
506
5
20
2.54
1.16
1.4
1.2
—
—
—
0
0
9
45
2.05
1.06
2.4
2.7
0.00
0.00
g/l
—
9
45
9
45
2.05
1.06
2.4
2.7
0.00
0.00
g/l
—
9
45
13
75
1.79
1.06
1.0
1.3
—
—
—
0
0
121
1091
1.36
1.05
4.8
4.0
14.65
14.77
pmol/l
0.24
115
988
138
1271
1.41
1.05
21.5
16.3
14.48
15.06
%
0.66
138
1255
17
107
1.65
1.04
2.4
2.3
4.15
6.90
ug/l
1.15
12
94
7
34
2.10
1.04
1.6
1.6
—
—
—
0
0
31
226
1.45
1.02
2.5
2.7
0.62
2.90
e6/l
2.50
15
125
5
23
2.21
0.98
1.6
1.6
—
—
—
0
0
65
540
1.33
0.98
4.3
3.6
—
—
—
0
0
33
246
1.42
0.97
1.4
1.4
—
—
—
0
0
12
70
1.77
0.95
20.9
6.1
26.02
25.10
mmol/l
0.45
12
70
9
52
1.77
0.94
2.4
2.0
—
—
—
0
0
6
29
2.11
0.90
1.5
1.3
—
—
—
0
0
151
1432
1.41
0.78
19.9
13.3
22.16
21.28
mg/l
0.14
127
1120
93
830
1.26
0.77
7.0
4.4
6.30
6.67
mmol/l
1.56
93
768
5
25
2.03
0.73
1.6
1.6
—
—
—
0
0
5
26
1.95
0.71
1.6
1.6
—
—
—
0
0
7
41
1.74
0.71
2.9
5.5
47.09
26.18
mg/l
—
7
35
7
41
1.74
0.71
3.0
5.5
22.71
186.94
mg/l
—
7
35
76
672
1.23
0.65
4.3
2.6
—
—
—
0
0
28
220
1.33
0.62
1.6
1.3
—
—
—
0
0
5
30
1.69
0.62
3.4
1.2
—
—
—
0
0
5
30
1.69
0.62
2.4
1.3
—
—
—
0
0
8
51
1.60
0.61
2.5
1.7
—
—
—
0
0
50
426
1.24
0.60
4.8
3.5
16.63
12.78
mg/mmol
0.13
35
253
52
449
1.23
0.55
2.6
2.3
61.46
68.93
u/l
0.29
46
415
139
1324
1.25
0.52
5.4
4.7
2.11
1.90
mu/l
0.98
131
1205
11
75
1.50
0.52
1.1
1.1
—
—
—
0
0
7
45
1.58
0.49
1.0
1.2
—
—
—
0
0
7
45
1.58
0.49
1.0
1.2
—
—
—
0
0
11
76
1.48
0.49
3.4
2.8
4.31
4.53
pmol/l
0.44
11
65
18
139
1.33
0.46
3.5
3.2
—
—
—
0
0
10
70
1.45
0.42
2.2
2.3
0.59
0.68
%
—
10
70
0
16
0.00
0.41
0.0
1.1
—
4.20
—
0
9
0
16
0.00
0.41
0.0
3.9
—
28.40
—
0
5
29
243
1.23
0.41
1.2
1.3
22.86
12.11
u/ml
0.31
16
87
0
17
0.00
0.41
0.0
1.1
—
4.18
—
0
17
39
338
1.20
0.40
1.9
1.5
24.34
21.73
nmol/l
0.56
33
283
143
1378
1.21
0.39
18.6
12.4
80.43
80.48
ml/min/173m2
0.01
124
1116
20
245
0.79
0.39
3.4
2.9
0.57
0.71
ug/l
0.50
15
145
5
36
1.40
0.38
1.0
2.3
—
—
—
0
0
6
41
1.48
0.36
1.8
1.6
28.00
38.27
nmol/l
—
6
41
164
1606
1.37
0.36
26.9
19.8
4.49
4.49
e12/l
0.02
158
1566
164
1606
1.37
0.36
28.1
19.8
40.35
40.24
%
0.10
157
1510
137
1415
0.85
0.33
4.9
4.5
5.76
5.97
mmol/l
1.91
129
1294
58
529
1.14
0.32
4.1
3.8
22.72
38.64
ng/l
1.24
40
375
8
64
1.26
0.28
2.0
1.5
—
—
—
0
0
61
564
1.13
0.27
2.8
1.9
92.15
98.48
pmol/l
0.67
31
260
36
322
1.15
0.26
2.2
2.0
2.68
3.19
mg/l
0.72
31
275
9
76
1.19
0.25
2.1
1.3
—
—
—
0
0
5
37
1.36
0.23
1.0
1.4
—
—
—
0
0
32
355
0.88
0.23
3.1
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
9
82
1.10
0.15
2.1
2.1
—
—
—
0
0
141
1435
0.91
0.15
4.7
4.3
1.42
1.49
mmol/l
1.08
135
1316
16
142
1.14
0.13
1.9
2.2
—
—
—
0
0
136
1383
0.92
0.12
4.4
3.9
1.32
1.27
mmol/l
0.25
126
1256
18
162
1.12
0.12
3.7
4.5
3.29
12.52
ug/l
2.02
12
133
145
1467
0.93
0.09
5.5
4.9
2.70
2.77
mmol/l
0.40
138
1344
7
66
1.06
0.08
2.1
1.8
—
—
—
0
0
15
163
0.91
0.07
8.9
7.4
—
—
—
0
0
143
1442
0.95
0.05
4.9
4.4
4.60
4.68
mmol/l
0.40
138
1331
26
254
1.03
0.00
1.5
1.7
1096.42
1182.18
nmol/l
0.20
19
190
13
126
1.03
0.00
2.0
1.6
—
—
—
0
0
33
334
0.99
0.00
4.2
4.1
22.58
21.92
%
0.07
12
149
37
371
1.00
0.00
5.8
3.8
0.00
0.00
estimate
-0.00
13
126
41
415
0.98
0.00
3.8
3.2
2291.46
1094.14
ng/l
0.75
36
359
12
118
1.02
0.00
2.1
2.1
—
—
—
0
0
5
50
1.00
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.2
—
241.60
—
0
5
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
59
1.02
-0.00
3.7
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERINFILTRATIVESKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERINFILTRATIVESKIN | 1.16 [0.89, 1.5] | 0.264 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 583 females with L12_OTHERINFILTRATIVESKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERINFILTRATIVESKIN | 1.305 [0.99, 1.71] | 0.055 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 442 males with L12_OTHERINFILTRATIVESKIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERINFILTRATIVESKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.224% |
| 5 | 0.767% | 1.307% |
| 10 | 1.624% | 3.239% |
| 15 | 3.128% | 6.275% |
| 20 | 5.646% | 10.793% |
Relationships between endpoints
↥Index endpoint: L12_OTHERINFILTRATIVESKIN – Other infiltrative disorders of skin and subcutaneous tissue
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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