urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
116 |
4. Check minimum number of eventsNone |
116 |
5. Include endpointsNone |
116 |
6. Filter based on genotype QC (FinnGen only) |
116 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria ex contactu
Similar endpoints
↥List of similar endpoints to
Contact urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 756 | 481 | 272 |
| Only index persons | 681 | 448 | 233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 33.99 | 36.01 | 30.25 |
| Only index persons | 36.48 | 36.75 | 35.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 116 | 87 | 29 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | 42.95 | 40.42 | 50.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 1001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.60
ICD-10 Finland
Allergic contact urticaria
1035.4
59.0
52
*
L50.6
ICD-10 Finland
Contact urticaria
+∞
30.8
28
*
L50.69
ICD-10 Finland
Other (non-immunological) contact urticaria
+∞
22.8
21
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
9.1
14.0
31
47
L50.8
ICD-10 Finland
Other urticaria
+∞
13.9
13
*
R06AE07
ATC
cetirizine; oral
3.9
9.6
63
303
L50.9
ICD-10 Finland
Urticaria, unspecified
22.4
8.7
12
6
L50.3
ICD-10 Finland
Dermatographic urticaria
86.2
7.5
8
*
XQ800
NOMESCO Finland
Prick test
5.3
6.4
19
42
J31.0
ICD-10 Finland
Chronic rhinitis
5.9
6.0
16
31
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
553
2.65
5.44
9.5
9.3
4.3
4.0
e9/l
0.49
69
489
15
42
3.95
4.95
1.2
1.5
—
—
—
0
0
52
299
2.34
4.71
3.2
3.0
—
—
—
0
0
14
40
3.84
4.49
1.2
1.3
—
—
—
0
0
14
41
3.75
4.34
1.6
1.4
—
—
—
0
0
29
141
2.41
3.73
2.5
2.4
1.3
1.1
e6/l
0.12
16
76
34
186
2.17
3.30
1.4
1.7
0.5
0.8
mg/l
1.66
24
141
25
120
2.38
3.29
2.6
2.8
0.8
0.8
mmol/l
0.38
25
111
94
755
2.29
3.12
4.2
4.1
14.5
14.5
pmol/l
0.08
88
698
110
976
3.45
3.03
15.6
11.4
21.5
20.3
mg/l
0.16
92
744
58
399
1.91
2.92
5.0
5.1
1.2
1.2
mmol/l
0.35
51
342
13
48
2.92
2.82
2.0
2.8
2.6
6.1
ug/l
1.59
13
43
39
238
1.96
2.78
6.5
3.3
0.0
0.0
estimate
—
8
88
39
240
1.94
2.71
3.2
2.7
0.2
0.2
e6/l
0.06
27
179
31
182
1.96
2.44
1.2
1.3
22.7
24.3
iu/ml
—
9
61
6
12
5.21
2.43
1.5
1.2
—
—
—
0
0
103
890
2.40
2.38
3.9
3.9
5.6
5.7
mmol/l
1.03
97
830
45
301
1.81
2.37
3.0
3.2
15.1
57.4
ng/l
1.35
29
167
10
35
3.03
2.37
1.2
1.4
—
—
—
0
0
10
35
3.03
2.37
2.9
2.7
53.7
50.2
%
—
10
35
85
690
1.87
2.29
8.9
6.7
72.3
75.1
u/l
0.47
79
646
5
9
5.75
2.23
1.2
1.2
—
—
—
0
0
31
189
1.87
2.17
3.1
3.0
2401.8
1166.3
ng/l
0.38
25
158
10
38
2.79
2.07
1.2
1.2
—
—
—
0
0
62
470
1.69
2.02
6.7
4.7
0.0
0.0
estimate
—
8
89
105
930
2.36
2.02
3.9
3.9
4.6
4.7
mmol/l
0.24
100
880
50
360
1.68
1.97
5.6
3.3
—
—
—
0
0
6
16
3.89
1.96
1.2
1.1
—
—
—
0
0
6
16
3.89
1.96
1.2
1.1
—
—
—
0
0
62
473
1.67
1.95
5.6
3.3
0.0
0.0
estimate
—
9
84
104
922
2.24
1.92
3.8
3.8
1.4
1.5
mmol/l
1.29
99
870
27
164
1.84
1.90
1.2
1.3
4.4
11.7
u/ml
0.86
13
70
61
466
1.65
1.89
5.5
3.2
0.0
0.0
estimate
—
9
92
24
142
1.87
1.83
3.5
3.5
109.4
68.0
ng/l
0.23
16
86
110
1015
2.62
1.80
15.8
12.4
68.7
70.7
umol/l
0.78
110
1015
22
131
1.84
1.64
1.5
1.8
—
—
—
0
0
5
15
3.43
1.54
1.8
1.9
—
—
—
0
0
6
21
2.95
1.52
1.0
1.0
—
—
—
0
0
104
940
2.03
1.52
4.5
4.2
2.9
2.8
mmol/l
0.30
98
882
9
37
2.55
1.52
2.1
1.3
—
—
—
0
0
95
839
1.73
1.46
4.3
4.7
37.5
38.4
mmol/mol
0.50
89
789
100
898
1.82
1.41
12.5
10.2
92.4
89.4
ml/min/173m2
0.73
89
710
5
17
3.02
1.37
2.0
1.4
—
—
—
0
0
5
17
3.02
1.37
1.4
1.5
—
—
—
0
0
34
242
1.57
1.33
1.6
1.2
1.0
1.5
u/ml
0.34
13
70
99
891
1.76
1.33
3.5
3.4
1.2
1.3
mmol/l
0.09
94
834
8
35
2.38
1.30
2.0
2.9
—
—
—
0
0
21
133
1.71
1.28
2.7
2.5
1.6
3.4
e6/l
—
9
69
33
236
1.56
1.26
1.5
1.4
—
—
—
0
0
30
215
1.53
1.13
1.9
1.8
—
—
—
0
0
36
271
1.48
1.08
2.6
1.7
—
—
—
0
0
15
92
1.72
1.03
8.8
6.9
—
—
—
0
0
7
35
2.06
1.02
1.1
1.2
—
—
—
0
0
7
35
2.06
1.02
1.1
1.2
—
—
—
0
0
33
247
1.47
1.01
2.0
2.1
137.8
190.7
u/l
0.66
33
238
11
63
1.82
0.94
8.6
5.0
1.7
1.3
mmol/l
0.34
11
58
6
29
2.13
0.91
2.0
2.1
—
—
—
0
0
6
29
2.13
0.91
2.2
2.3
—
—
—
0
0
15
96
1.65
0.89
1.4
1.6
—
—
—
0
0
15
96
1.65
0.89
1.4
1.6
—
—
—
0
0
9
53
1.76
0.77
1.1
1.9
—
—
—
0
0
5
23
2.22
0.77
1.6
1.3
—
—
—
0
0
5
25
2.04
0.73
1.2
1.5
—
—
—
0
0
15
103
1.52
0.69
3.1
3.1
1.1
1.0
mmol/l
0.25
15
91
5
28
1.82
0.67
1.2
1.1
—
—
—
0
0
5
29
1.76
0.64
1.0
1.2
—
—
—
0
0
10
64
1.62
0.61
1.1
1.0
—
—
—
0
0
10
64
1.62
0.61
1.4
1.4
—
—
—
0
0
7
46
1.55
0.49
1.3
1.5
—
—
—
0
0
19
147
1.35
0.49
2.0
3.0
2.5
2.4
mmol/l
0.79
19
126
13
94
1.43
0.48
2.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
7.7
—
0
8
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
7.5
—
0
14
23
191
1.25
0.37
2.4
2.2
—
—
—
0
0
6
41
1.49
0.36
1.5
1.6
—
—
—
0
0
6
45
1.35
0.34
4.0
3.7
25.6
25.3
mmol/l
—
6
45
82
775
1.20
0.34
4.0
3.6
—
—
—
0
0
37
332
1.17
0.28
2.0
1.6
98.8
98.3
pmol/l
0.03
22
162
24
207
1.20
0.28
2.6
2.4
—
—
—
0
0
15
123
1.25
0.27
2.8
1.8
—
—
—
0
0
6
84
0.70
0.25
1.5
1.3
—
105.9
—
0
34
10
124
0.79
0.23
2.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
5.5
—
11.8
—
0
12
0
12
0.00
0.21
0.0
1.8
—
13.0
—
0
12
5
69
0.71
0.17
1.2
1.7
—
—
—
0
0
9
80
1.14
0.15
3.0
3.1
—
—
—
0
0
31
290
1.09
0.11
1.9
3.2
2.4
2.4
mmol/l
0.38
31
252
50
481
1.07
0.09
3.1
3.8
—
—
—
0
0
5
62
0.80
0.08
1.2
1.6
—
—
—
0
0
5
62
0.80
0.08
1.2
1.6
—
—
—
0
0
5
62
0.80
0.08
1.2
1.6
—
—
—
0
0
11
119
0.92
0.04
1.3
1.6
—
—
—
0
0
16
151
1.07
0.03
3.4
4.1
1.0
1.8
ug/l
3.86
16
135
48
482
0.99
0.00
3.0
2.5
85.6
70.2
ug/l
0.37
43
449
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
15.2
—
0
6
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
54
0.92
0.00
1.8
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
0.00
1.0
2.0
2.5
2.8
mg/l
—
5
33
0
5
0.00
0.00
0.0
1.4
—
56.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.6
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.0
—
—
—
0
0
6
63
0.95
0.00
2.5
2.4
61.3
65.5
ng/l
—
6
58
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTIGA_CONTACT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTIGA_CONTACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTIGA_CONTACT – Contact urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data