urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
122 |
4. Check minimum number of eventsNone |
122 |
5. Include endpointsNone |
122 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria ex contactu
Similar endpoints
↥List of similar endpoints to
Contact urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 756 | 481 | 272 |
| Only index persons | 681 | 448 | 233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 33.99 | 36.01 | 30.25 |
| Only index persons | 36.48 | 36.75 | 35.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118 | 89 | 29 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | 42.90 | 41.46 | 47.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 122
- Matched controls
- 1220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.60
ICD-10 Finland
Allergic contact urticaria
+∞
78.9
67
*
L50.6
ICD-10 Finland
Contact urticaria
+∞
36.3
33
*
L50.69
ICD-10 Finland
Other (non-immunological) contact urticaria
+∞
26.0
24
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
8.0
23.0
38
65
L50.8
ICD-10 Finland
Other urticaria
+∞
16.0
15
*
XQ800
NOMESCO Finland
Prick test
7.6
15.7
25
40
R06AE07
ATC
cetirizine; oral
3.6
10.8
79
409
L50.3
ICD-10 Finland
Dermatographic urticaria
119.9
10.6
11
*
L50.9
ICD-10 Finland
Urticaria, unspecified
16.5
10.3
16
11
L50.0
ICD-10 Finland
Allergic urticaria
28.8
10.0
13
5
R06AX27
ATC
desloratadine; oral
3.2
8.8
57
265
H02AB06
ATC
prednisolone; systemic
3.0
8.3
73
401
XQ802
NOMESCO Finland
Epicutan test
8.6
7.7
16
21
M54.4
ICD-10 Finland
Lumbago with sciatica
3.4
7.7
34
125
H02AB04
ATC
methylprednisolone; systemic
3.7
7.2
26
83
R03DC03
ATC
montelukast; oral
3.3
7.1
32
118
T78.4
ICD-10 Finland
Allergy, unspecified
6.9
7.1
17
28
J31.0
ICD-10 Finland
Chronic rhinitis
4.1
6.9
21
59
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
6.9
35
139
C01CA24
ATC
epinephrine; parenteral
4.5
6.6
17
42
N02AX02
ATC
tramadol; systemic, rectal
2.6
6.2
58
316
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
6.1
61
342
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
580
2.74
6.04
9.3
9.3
4.27
4.00
e9/l
0.55
74
511
16
44
4.03
5.41
1.2
1.5
—
—
—
0
0
15
43
3.84
4.78
1.2
1.3
—
—
—
0
0
54
314
2.29
4.70
3.2
3.0
—
—
—
0
0
31
148
2.47
4.15
2.7
2.4
1.25
1.07
e6/l
0.10
17
80
37
194
2.30
4.01
1.6
1.7
0.54
0.79
mg/l
1.90
27
147
14
45
3.38
3.78
1.6
1.4
—
—
—
0
0
116
1021
3.77
3.50
15.9
11.6
21.18
20.18
mg/l
0.14
98
776
9
19
5.02
3.31
1.2
1.1
—
—
—
0
0
9
19
5.02
3.31
1.2
1.1
—
—
—
0
0
26
128
2.31
3.21
2.5
2.8
0.83
0.81
mmol/l
0.53
26
119
99
799
2.27
3.18
4.1
4.1
14.46
14.45
pmol/l
0.02
92
737
61
423
1.88
2.96
5.0
5.1
1.21
1.22
mmol/l
0.36
54
365
19
85
2.46
2.88
6.3
6.3
104.32
104.44
mmol/l
0.04
19
85
41
251
1.95
2.88
3.4
2.7
0.22
0.22
e6/l
0.01
29
186
13
48
2.91
2.82
2.0
2.7
2.61
6.15
ug/l
1.59
13
43
27
148
2.06
2.55
3.6
3.5
103.24
121.62
ng/l
0.08
17
90
33
196
1.94
2.50
3.0
3.0
2237.41
1146.84
ng/l
0.36
27
162
11
38
3.08
2.49
1.2
1.4
—
—
—
0
0
39
246
1.86
2.46
6.5
3.4
0.00
0.00
estimate
—
8
92
6
12
5.20
2.43
1.5
1.2
—
—
—
0
0
46
309
1.78
2.36
2.9
3.3
15.10
55.97
ng/l
1.34
29
172
11
40
2.92
2.34
1.9
1.4
—
—
—
0
0
88
715
1.83
2.30
8.9
6.8
71.80
76.31
u/l
0.91
83
670
52
365
1.74
2.28
5.7
10.9
1.01
1.14
inr
2.59
13
116
11
41
2.85
2.27
1.2
1.1
—
—
—
0
0
5
9
5.74
2.23
1.2
1.2
—
—
—
0
0
107
935
2.17
2.14
3.9
3.8
5.60
5.74
mmol/l
0.90
101
871
10
37
2.85
2.12
2.9
2.6
53.70
49.50
%
—
10
37
10
38
2.77
2.06
2.5
2.2
0.62
0.70
%
—
10
38
64
486
1.67
2.04
5.4
3.3
0.00
0.00
estimate
—
10
101
31
193
1.81
2.01
1.2
1.3
22.67
24.25
iu/ml
—
9
63
64
488
1.66
1.99
6.7
4.7
0.00
0.00
estimate
—
8
93
24
139
1.90
1.94
1.7
1.8
—
—
—
0
0
64
491
1.64
1.92
5.5
3.4
0.00
0.00
estimate
—
9
88
38
258
1.69
1.82
1.6
1.3
1.03
1.47
u/ml
0.32
13
73
7
25
2.91
1.67
1.6
1.3
—
—
—
0
0
50
373
1.58
1.62
5.6
3.3
—
—
—
0
0
6
20
3.10
1.60
6.8
3.9
59.17
60.40
%
—
6
20
23
140
1.79
1.59
2.9
2.6
1.40
3.27
e6/l
—
10
73
115
1067
2.35
1.57
16.1
12.5
68.59
70.38
umol/l
0.69
115
1067
6
21
2.95
1.52
1.0
1.0
—
—
—
0
0
27
175
1.70
1.51
1.2
1.3
4.38
11.16
u/ml
0.81
13
74
99
877
1.68
1.43
4.3
4.7
37.39
38.38
mmol/mol
0.56
93
823
5
17
3.02
1.37
1.8
1.9
—
—
—
0
0
108
983
1.86
1.37
4.4
4.1
2.87
2.80
mmol/l
0.30
103
920
5
18
2.85
1.30
2.0
1.3
—
—
—
0
0
17
101
1.79
1.28
1.6
1.6
—
—
—
0
0
104
942
1.71
1.27
13.0
10.4
92.50
89.85
ml/min/173m2
0.63
92
744
103
931
1.68
1.26
3.5
3.4
1.25
1.26
mmol/l
0.05
98
869
6
25
2.47
1.26
1.5
1.5
7.88
7.72
g/l
—
6
25
6
25
2.47
1.26
1.5
1.5
—
—
—
0
0
6
25
2.47
1.26
1.5
1.5
3.90
3.86
g/l
—
6
25
17
102
1.77
1.24
1.6
1.5
—
—
—
0
0
8
37
2.24
1.24
2.0
2.7
—
—
—
0
0
39
291
1.50
1.22
2.8
1.7
—
—
—
0
0
5
20
2.56
1.16
1.4
1.5
—
—
—
0
0
11
59
1.95
1.11
1.1
1.8
—
—
—
0
0
31
226
1.50
1.07
1.8
2.0
—
—
—
0
0
33
249
1.45
0.96
1.5
1.4
—
—
—
0
0
7
37
1.94
0.95
1.1
1.2
—
—
—
0
0
7
37
1.94
0.95
1.1
1.2
—
—
—
0
0
6
28
2.20
0.93
1.2
1.1
—
—
—
0
0
15
96
1.64
0.89
8.8
6.7
—
—
—
0
0
33
253
1.42
0.88
2.0
2.1
137.85
187.82
u/l
0.63
33
244
6
31
1.98
0.85
2.0
2.1
—
—
—
0
0
6
31
1.98
0.85
2.2
2.3
—
—
—
0
0
11
67
1.71
0.78
1.1
1.0
—
—
—
0
0
11
69
1.65
0.71
1.4
1.4
—
—
—
0
0
5
27
1.89
0.69
1.0
1.3
—
—
—
0
0
7
43
1.67
0.68
1.7
1.6
—
—
—
0
0
5
29
1.75
0.64
1.0
1.2
—
—
—
0
0
20
149
1.41
0.63
2.0
2.9
2.47
2.43
mmol/l
1.05
20
128
18
132
1.43
0.61
2.5
1.8
—
—
—
0
0
41
349
1.26
0.54
2.1
1.7
100.24
98.07
pmol/l
0.16
24
168
14
101
1.44
0.52
2.4
1.6
—
—
—
0
0
88
823
1.25
0.47
4.5
3.6
—
—
—
0
0
7
49
1.45
0.47
1.3
1.5
—
—
—
0
0
7
50
1.42
0.46
3.6
4.1
26.21
25.47
mmol/l
—
7
50
6
92
0.63
0.44
1.5
1.3
—
101.60
—
0
36
15
114
1.36
0.43
3.1
3.1
1.08
1.06
mmol/l
0.11
15
102
5
32
1.59
0.43
1.0
1.3
—
—
—
0
0
27
225
1.26
0.42
2.5
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
25
207
1.26
0.41
2.4
2.2
—
—
—
0
0
97
931
1.20
0.31
17.2
14.0
14.21
14.36
%
0.11
97
924
7
56
1.26
0.30
1.6
2.0
3.18
3.45
mg/l
—
7
37
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
5.5
—
11.82
—
0
12
0
13
0.00
0.21
0.0
1.8
—
13.03
—
0
13
6
75
0.79
0.16
1.2
1.7
—
—
—
0
0
33
305
1.11
0.16
1.8
3.2
2.37
2.36
mmol/l
0.41
33
267
11
127
0.85
0.13
2.5
1.7
—
—
—
0
0
53
513
1.06
0.08
3.0
2.6
82.32
69.66
ug/l
0.33
48
477
9
83
1.09
0.07
3.0
3.1
—
—
—
0
0
16
151
1.07
0.03
3.4
4.1
0.96
1.80
ug/l
3.85
16
135
51
500
1.03
0.03
2.1
2.5
—
—
—
0
0
12
126
0.95
0.00
1.3
1.6
—
—
—
0
0
6
67
0.89
0.00
1.2
1.6
—
—
—
0
0
6
67
0.89
0.00
1.2
1.6
—
—
—
0
0
6
67
0.89
0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
10.32
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
-0.00
2.5
2.6
61.33
64.68
ng/l
—
6
62
5
54
0.92
-0.00
1.8
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
15.17
—
0
6
0
5
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
4.89
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTIGA_CONTACT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTIGA_CONTACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTIGA_CONTACT – Contact urticaria
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data