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Problems related to care-provider dependency

Z21_PROBL_RELATED_CARE__DEPENDENCY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z74
  • Cause of death: ICD-10 Z74

2 out of 7 registries used, show all original rules.

271

4. Check minimum number of events

None

271

5. Include endpoints

None

271

6. Filter based on genotype QC (FinnGen only)

271

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_OTH_CIRCUMSTANC1

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 271 111 160
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 75.45 74.76 75.92

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
239
Matched controls
2390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z74.0
ICD-10 Finland
Need for assistance due to reduced mobility
+∞
95.3
85
*
Z74.2
ICD-10 Finland
Need for assistance at home and no other household member able to render care
+∞
57.6
53
*
Z74.1
ICD-10 Finland
Need for assistance with personal care
+∞
50.8
47
*
Z74.8
ICD-10 Finland
Other problems related to care-provider dependency
+∞
37.5
35
*
Z75.5
ICD-10 Finland
Holiday relief care
+∞
35.3
33
*
Z74.9
ICD-10 Finland
Problem related to care-provider dependency, unspecified
+∞
21.1
20
*
R51
NOMESCO Finland
Aids services
217.0
19.9
20
*
A29
ICPC
General symptom/complaint other
5.9
19.8
60
128
N05AX08
ATC
risperidone; systemic
5.2
17.5
59
141
N03AG01
ATC
valproic acid; systemic, rectal
7.9
15.9
37
54
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.2
14.3
47
108
A06AD11
ATC
lactulose; oral
3.3
14.0
88
361
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
13.0
113
568
F03
ICD-10 Finland
Unspecified dementia
4.5
12.7
48
127
N05AH04
ATC
quetiapine; oral
3.8
12.3
57
182
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.4
12.1
66
241
A28
ICPC
Limited function/disability NOS
3.2
11.8
74
297
N03AF01
ATC
carbamazepine; oral, rectal
6.0
11.5
32
60
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.2
11.3
66
251
WYA20
NOMESCO Finland
Home visit
12.0
11.3
20
18
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.4
11.1
29
50
N05BA04
ATC
oxazepam; oral
2.9
11.1
80
351
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.8
11.0
49
151
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.8
10.7
48
148
L89
ICD-10 Finland
Decubitus ulcer and pressure area
9.4
10.0
20
23
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.6
9.9
47
152
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.7
9.9
28
54
N05BA01
ATC
diazepam; systemic, rectal
3.5
9.8
47
154
N06AB04
ATC
citalopram; systemic
2.8
9.7
70
304
SPAT1262
SPAT
Handing over of treatment supplies
3.0
9.4
60
241
C03CA01
ATC
furosemide; systemic
2.4
9.3
127
776
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
38.2
9.1
11
*
N05AH03
ATC
olanzapine; systemic
5.8
9.0
25
47
R53
ICD-10 Finland
Malaise and fatigue
2.7
9.0
73
338
SPAT1229
SPAT
Assessment of need for aid
3.8
9.0
39
117
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.6
8.8
30
72
N03AE01
ATC
clonazepam; systemic
5.8
8.7
24
45
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
12.2
8.7
15
13
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.5
8.7
30
73
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.3
8.5
22
38
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.4
8.5
14
11
WW200
SPAT
NA
4.2
8.5
32
85
N03AX14
ATC
levetiracetam; systemic
11.3
8.4
15
14
N02AA05
ATC
oxycodone; systemic
2.9
8.3
56
231
CA1ME
NOMESCO Finland
Ultrasound oculometry
17.9
8.2
12
7
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
8.1
61
269
N05AA02
ATC
levomepromazine; systemic
5.9
7.9
21
38
K90
ICPC
Stroke/cerebrovascular accident
7.9
7.8
17
23
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
7.8
54
226
N05AD01
ATC
haloperidol; systemic
5.5
7.8
22
43
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
7.7
51
207
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
12.4
7.7
13
11
N30.0
ICD-10 Finland
Acute cystitis
2.9
7.5
46
179
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
8.8
7.4
15
18
XKW99
NOMESCO Finland
Other physiological examination of urinary or male genital system
9.8
7.4
14
15
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.9
7.3
23
51
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.6
7.3
20
38
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
7.1
96
564
WX704
NOMESCO Finland
Intubation
4.2
6.9
25
64
N03AX12
ATC
gabapentin; oral
3.1
6.9
39
143
SPAT1249
SPAT
Treatment-related counselling outside office
2.2
6.8
91
527
K59.0
ICD-10 Finland
Constipation
4.2
6.8
25
65
WX892
NOMESCO Finland
Monitored bed care
3.7
6.7
28
82
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.6
6.7
29
88
M03BX01
ATC
baclofen; systemic
12.7
6.6
11
9
N05CD07
ATC
temazepam; oral
2.5
6.5
55
256
WZC00
SPAT
NA
5.5
6.5
18
35
Z75.0
ICD-10 Finland
Medical services not available in home
71.6
6.5
7
*
P29
ICPC
Psychological sympt/compl other
5.8
6.4
17
31
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.2
6.4
23
59
N06DX01
ATC
memantine; oral
2.8
6.4
41
164
J01MA02
ATC
ciprofloxacin; systemic
2.0
6.3
105
661
A60
ICPC
General and Unspecified, Result test/procedure
4.7
6.3
20
45
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
4.1
6.3
23
60
Z74.3
ICD-10 Finland
Need for continuous supervision
+∞
6.3
6
*
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
8.0
6.2
13
17
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.4
6.2
55
263
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
6.2
71
385
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
13.0
6.1
10
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PROBL_RELATED_CARE__DEPENDENCY – Problems related to care-provider dependency

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).