Yaws

AB1_YAWNS_WIDE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — A66 Hospital discharge: ICD-10 — A66 Cause of death: ICD-10 — A66 3 out of 7 registries used, show all original rules.	140
4. Check minimum number of events None	140
5. Include endpoints None	140
6. Filter based on genotype QC (FinnGen only)	134

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_SPIROCHAETAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF13

NAME	AB1_YAWNS_WIDE
CONTROL_EXCLUDE	AB1_OTHER_SPIROCHAETAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	A66
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A66
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A66
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Yaws based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	134	77	57
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	56.15	52.86	60.59

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1400

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A66.1

ICD-10 Finland

Multiple papillomata and wet crab yaws

+∞

58.5

A66.3

ICD-10 Finland

Hyperkeratosis of yaws

+∞

28.1

A66.2

ICD-10 Finland

Other early skin lesions of yaws

+∞

22.5

A66.9

ICD-10 Finland

Yaws, unspecified

+∞

14.8

A66.0

ICD-10 Finland

Initial lesions of yaws

+∞

9.5

A66

ICD-10 Finland

Yaws

+∞

8.4

A69.2

ICD-10 Finland

Lyme disease

+∞

8.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768804) Tissue Pathology biopsy report

431

2.38

5.96

2.5

2.0

—

(3049717) Cytology report of Urine Cyto stain

4.00

3.48

3.2

2.8

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.40

2.79

1.8

2.2

73.75

71.15

ml/min/173m2

0.10

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

227

1.93

2.79

2.1

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

100

814

1.80

2.51

3.3

—

(3031040) Bacteria [#/volume] in Urine by Automated count

717

1.71

2.38

4.2

3.5

—

25.42

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

385

1.71

2.35

2.2

1.9

91.87

90.60

pmol/l

0.07

204

(3037467) Urinalysis macro (dipstick) panel - Urine

750

1.66

2.11

4.6

3.7

—

(3044640) Blood type and Crossmatch panel - Blood

310

1.67

2.00

2.2

2.3

—

(4035726) Immunohistochemistry procedure

2.11

1.95

1.3

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.49

1.65

1.2

1.6

51.80

36.43

nmol/l

—

(3002256) Pathology report gross observation

130

1.82

1.65

1.6

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

112

1.81

1.44

1.4

—

(3018095) Leukocytes [#/volume] in Urine

370

1.50

1.42

4.0

3.2

16.43

61.07

e6/l

1.62

270

(3002582) Erythrocytes [#/volume] in Urine

308

1.52

1.39

3.8

2.8

16.25

58.58

e6/l

1.23

248

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.90

1.37

3.5

2.2

0.21

0.22

g/l

0.24

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.01

1.37

1.0

1.1

—

(3024928) Oxygen saturation in Venous blood

2.84

1.29

5.0

3.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

126

1166

1.81

1.28

14.1

12.0

21.92

21.48

mg/l

0.05

100

898

(3020682) Albumin/Creatinine [Ratio] in Urine

314

1.48

1.26

4.3

3.9

13.29

12.78

mg/mmol

0.02

197

(4200892) Spirometry reversibility

1.83

1.25

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

280

1.49

1.22

3.7

2.8

0.18

0.38

e6/l

1.16

216

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.81

1.20

2.2

—

(40768443) Skin Pathology biopsy report

2.08

1.19

1.1

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

495

1.41

1.18

2.9

2.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.55

1.16

1.4

1.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

112

1.70

1.15

3.3

6.7

104.11

104.01

mmol/l

0.03

112

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.18

1.07

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

484

1.38

1.05

6.6

6.8

1.22

mmol/l

0.01

419

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.32

1.04

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.32

1.04

1.4

1.2

—

(3000494) Fungus identified in Specimen by Culture

125

1.60

1.00

1.2

1.6

—

(3012516) Albumin [Mass/volume] in Urine

291

1.42

1.00

4.1

3.3

1993.10

86.54

mg/l

0.48

196

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.76

0.99

1.1

1.4

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.99

0.0

5.0

—

32.72

—

(40768793) Breast Pathology biopsy report

0.00

0.96

0.0

1.3

—

(3022096) Basophils/100 leukocytes in Blood

509

1.35

0.95

7.0

5.6

0.68

0.66

0.10

475

(40768797) Stomach Pathology biopsy report

135

1.56

0.95

1.4

1.2

—

(40761536) Microorganisms panel - Urine sediment

101

0.48

0.94

6.0

3.1

—

(3006504) Eosinophils/100 leukocytes in Blood

530

1.34

0.93

6.6

5.4

3.24

2.79

0.72

498

(3013650) Neutrophils [#/volume] in Blood by Automated count

659

1.34

0.91

10.3

9.0

4.75

4.12

e9/l

0.80

583

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

123

1153

1.55

0.90

5.0

4.6

2.80

mmol/l

0.00

115

1066

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

121

1131

1.51

0.89

4.4

4.2

4.68

mmol/l

0.03

113

1053

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.04

0.88

14.5

2.5

130.33

189.37

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.04

0.88

1.0

1.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

553

1.33

0.88

6.4

5.5

29.94

28.33

0.55

522

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

181

1.46

0.88

1.4

1.3

12.79

36.58

iu/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

253

1.40

0.86

1.8

1.9

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

804

1.33

0.86

3.6

3.0

46.75

43.68

u/l

0.17

760

(3052851) Hemolysis interference index of Serum or Plasma

1.98

0.85

3.8

2.7

—

(3018418) pH of Serum or Plasma

299

1.37

0.85

3.9

3.6

7.40

—

(40758558) Short blood count panel - Blood

300

1.37

0.83

9.8

6.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

120

1124

1.47

0.83

4.2

1.44

1.46

mmol/l

0.25

113

1037

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

186

1.42

0.77

5.0

3.3

19.75

108.33

ng/l

1.36

131

(36304419) Bacteria [Presence] in Urine

277

1.35

0.75

3.9

2.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.84

0.73

1.3

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.84

0.73

1.4

2.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.04

0.73

1.8

2.0

—

(4034850) Laboratory test

1.79

0.72

3.4

11.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.59

0.71

4.8

5.1

25.89

25.35

mmol/l

—

(3005033) Fetal Nuchal fold Thickness US

1.96

0.71

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.96

0.71

1.4

—

(3036489) Thrombin time

1.74

0.71

5.7

2.0

19.86

21.97

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.70

0.69

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

366

1.29

0.67

3.8

2.9

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.81

0.67

1.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.81

0.67

1.4

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

2.2

1.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.67

0.63

2.1

2.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

112

1052

1.32

0.62

4.9

4.6

1.88

1.93

mu/l

0.17

101

966

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

231

1.32

0.60

2.5

1.7

0.74

1.31

mg/l

1.14

190

(3022217) INR in Platelet poor plasma by Coagulation assay

467

1.25

0.60

16.5

11.7

1.39

1.24

inr

0.45

155

(3015377) Calcium [Moles/volume] in Serum or Plasma

362

1.27

0.60

2.6

2.8

2.35

mmol/l

0.08

326

(3044889) 12 lead EKG panel

764

1.25

0.60

3.5

3.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.60

0.0

3.6

—

5.01

—

(3012501) Base excess in Blood by calculation

0.00

0.60

0.0

3.6

—

2.65

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.60

0.0

3.6

—

8.47

—

(3000330) Specific gravity of Urine by Test strip

1.54

0.59

3.0

3.5

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.75

0.58

2.7

10.8

24.40

24.59

mmol/l

—

(40761535) Cells panel - Urine sediment

0.55

0.58

2.6

3.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

291

0.75

0.57

1.5

1.3

7.40

2.18

u/ml

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.70

0.57

5.5

4.2

1.46

1.49

mg/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.70

0.57

1.5

1.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.70

0.57

1.0

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

549

1.23

0.55

3.5

3.3

0.00

estimate

—

104

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

111

1048

1.29

0.54

6.0

5.3

38.64

39.30

mmol/mol

0.41

106

982

(3019832) Treponema pallidum Ab [Presence] in Serum

136

1.37

0.52

1.9

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

542

1.22

0.52

4.5

4.4

0.00

estimate

—

113

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

855

1.22

0.49

8.2

6.8

84.18

77.49

u/l

0.69

800

(3045414) Leukocytes [Presence] in Urine

1.48

0.47

3.1

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

221

1.27

0.47

2.7

3.3

—

(3003694) ABO and Rh group [Type] in Blood

317

1.23

0.44

1.7

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

870

1.21

0.44

4.1

4.0

14.47

14.68

pmol/l

0.32

796

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.63

0.43

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.63

0.43

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.63

0.43

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.63

0.43

1.4

—

(3013115) Eosinophils [#/volume] in Blood

581

1.19

0.42

7.9

5.9

0.22

0.19

e9/l

0.59

516

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.53

0.42

1.6

—

(36660697) Celiac disease serology panel - Serum

104

0.66

0.41

1.0

1.2

—

(3019060) Gas panel - Arterial blood

1.35

0.41

2.1

12.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3023368) Bacteria identified in Blood by Culture

263

1.23

0.40

4.3

4.2

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.33

0.40

9.1

4.0

129.00

131.69

g/l

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.40

0.0

2.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.40

0.0

2.7

—

105.11

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.40

0.0

2.1

—

17.36

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.40

0.0

2.7

—

4.04

—

(3019198) Lymphocytes [#/volume] in Blood

583

1.18

0.40

6.4

5.4

2.01

1.95

e9/l

0.15

529

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.44

0.39

2.6

2.7

25.64

25.47

mmol/l

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.39

0.39

1.4

1.8

0.97

1.19

g/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

143

1.30

0.39

1.8

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.39

0.0

1.7

—

(3027008) Opiates [Presence] in Urine

1.37

0.39

1.3

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.37

0.39

1.3

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.40

0.38

7.4

2.1

113.20

86.47

—

(3028300) Cannabinoids [Presence] in Urine

1.35

0.38

1.3

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.35

0.38

1.3

1.4

—

(3001604) Monocytes [#/volume] in Blood

565

1.17

0.38

6.0

5.3

0.58

0.57

e9/l

0.11

496

(3015736) pH of Urine

428

1.18

0.38

2.3

3.1

6.29

5.79

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

113

1083

1.23

0.37

4.1

3.8

1.41

1.29

mmol/l

0.73

107

998

(3006315) Basophils [#/volume] in Blood

566

1.17

0.37

6.0

5.3

0.04

e9/l

0.82

498

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

108

1.33

0.37

1.9

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.45

0.36

1.8

2.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

192

1.24

0.35

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

312

0.83

0.32

4.6

3.4

0.00

estimate

—

110

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.36

0.31

2.5

2.0

—

(3035350) Ketones [Presence] in Urine by Test strip

545

1.14

0.29

3.5

3.3

0.00

0.01

estimate

—

121

(3016879) Cocaine [Presence] in Urine

1.26

0.28

1.3

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.26

0.28

1.1

1.2

—

(3019225) pH of Specimen

1.30

0.27

2.1

3.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.21

0.27

1.6

1.8

—

(3025941) Bacteria identified in Stool by Culture

1.25

0.26

1.1

1.2

—

(3022621) pH of Urine by Test strip

1.23

0.26

2.4

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.29

0.25

1.5

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

124

1.23

0.25

1.8

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

267

1.16

0.24

4.3

4.4

29.04

20.60

—

130

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.36

0.24

1.2

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

211

1.17

0.22

1.9

1.6

338.71

464.92

pmol/l

3.53

184

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

154

1.19

0.22

1.6

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

271

0.86

0.22

1.2

1.3

3.42

2.33

g/l

0.60

160

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

145

1.20

0.22

2.2

1.9

—

(3013512) EKG study

289

1.14

0.21

3.8

3.4

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.4

—

119.52

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

236.91

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.21

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.4

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.21

0.0

1.1

—

8.12

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.5

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.5

—

90.82

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.20

0.0

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.20

0.0

4.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

195

1.15

0.19

2.4

2.2

—

(3026008) Bacteria identified in Urine by Culture

292

1.12

0.18

4.2

2.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

186

1.15

0.18

1.8

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

254

1.13

0.17

1.8

1.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

110

1073

1.12

0.17

14.7

11.3

84.10

85.15

ml/min/173m2

0.17

864

(3021589) Normoblasts [#/volume] in Blood

530

0.91

0.17

9.7

8.5

0.00

e9/l

0.42

442

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.12

0.16

1.5

1.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.79

0.15

2.7

4.3

1.21

1.22

mmol/l

—

(3042936) Bacteria identified in Isolate by Culture

141

1.15

0.14

2.0

2.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

182

1.12

0.12

1.5

1.3

1.35

13.48

u/ml

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.18

0.11

1.8

1.4

—

(3022145) Colonoscopy Study observation

125

1.13

0.10

1.1

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

519

1.07

0.10

6.7

5.5

—

(40761511) CBC panel - Blood by Automated count

121

1226

0.90

0.10

11.7

11.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.14

0.10

1.4

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.09

0.09

1.2

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.14

0.09

1.3

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.09

0.09

1.3

1.9

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.07

0.09

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.10

0.08

1.6

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.10

0.08

1.1

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

333

0.95

0.05

3.8

2.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

179

1.07

0.05

2.1

2.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

110

1091

1.04

0.02

5.1

4.3

5.95

5.86

mmol/l

0.35

105

1001

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

107

0.93

0.02

2.7

3.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

193

1.04

0.01

2.6

2.9

0.95

0.74

ug/l

0.26

119

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.07

0.01

2.5

1.7

—

(21494755) Public health laboratory ask at order entry panel

144

1.05

0.00

1.5

1.4

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

169

1.01

0.00

5.1

3.8

0.82

0.81

mmol/l

0.03

162

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

441

1.00

0.00

3.5

3.3

—

(1761868) Lipid panel - Serum or Plasma

439

1.00

0.00

2.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

2.7

1.7

—

(3000492) Spirometry study

112

0.98

0.00

1.2

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

125

0.96

0.00

3.6

7.1

—

(3000991) Gas panel - Venous blood

0.97

0.00

5.0

6.7

—

(3036180) Methadone [Presence] in Urine

0.00

-0.00

0.0

1.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(43055246) Days in therapeutic INR range/Days INR result determined [Ratio]

0.00

-0.00

0.0

3.6

—

71.60

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.4

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

-0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

1.71

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.6

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

1.8

—

7.67

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.1

—

226.43

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

-0.00

0.0

2.0

—

(3008898) HLA-B27 [Presence]

0.87

-0.00

1.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

6.06

—

(3042891) Cardiolipin IgM Ab [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.4

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

277.11

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

400

1.00

-0.00

3.1

3.8

1738.39

20.55

ng/l

0.50

257

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.6

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.6

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

3.21

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.4

—

37.90

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

90.40

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

6.8

—

227.83

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

53.00

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1673.83

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_YAWNS_WIDE – Yaws

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Yaws

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Yaws (AB1_YAWNS_WIDE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints