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This is a non-core endpoint: only basic statistics are computed.

Melanoma in situ, other sites/unspecified

CD2_INSITU_MELANOMA_NOS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 102 52 50
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 66.86 63.36 70.50

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
931
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.9
ICD-10 Finland
Melanoma in situ, unspecified
+∞
98.0
76
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
31.0
29.0
39
21
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
79.6
22.1
24
*
D03.8
ICD-10 Finland
Melanoma in situ of other sites
+∞
20.6
19
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
24.8
19.2
27
15
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
16.1
15
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
176.6
14.9
15
*
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
176.6
14.9
15
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
13.9
13
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
13.9
13
*
L57.0
ICD-10 Finland
Actinic keratosis
9.8
13.3
28
39
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
13.8
11.7
20
18
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
+∞
11.7
11
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.4
11.0
25
39
D03.5
ICD-10 Finland
Melanoma in situ of trunk
+∞
10.6
10
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.2
10.4
30
66
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
23.2
10.2
14
7
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
13.6
10.1
17
15
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
+∞
9.5
9
*
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
9.5
9
*
TQW99
NOMESCO Finland
Other minor procedure on skin
11.8
8.9
16
16
A04AA02
ATC
granisetron; systemic, transdermal
+∞
8.5
8
*
130
Kela drug reimbursment
Malignant tumour
+∞
8.5
8
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
86.7
7.5
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.4
7
*
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
+∞
7.4
7
*
C43
ICD-10 Finland
Malignant melanoma of skin
+∞
7.4
7
*
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
+∞
7.4
7
*
C43.99
ICD-10 Finland
Unspecified localization of malignant melanoma of the skin other or unspecified histology
+∞
7.4
7
*
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
8.2
7.4
16
23
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
43.3
6.9
8
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
24.6
6.8
9
*
S18
ICPC
Laceration/cut
3.2
6.5
53
275
L03AA13
ATC
pegfilgrastim; parenteral
+∞
6.3
6
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
6.3
6
*
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
+∞
6.3
6
*
S77
ICPC
Malignant neoplasm of skin
+∞
6.3
6
*
XQ846
NOMESCO Finland
Digital dermatoscopy and registration of nevi
+∞
6.3
6
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
SPAT1153
SPAT
Removal of sutures
3.2
6.3
45
212
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
16.4
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
59
14.48
39.96
1.8
1.0
—
—
—
0
0
83
241
14.12
33.27
4.7
1.5
—
—
—
0
0
28
23
16.40
29.37
1.5
1.3
—
—
—
0
0
45
244
2.51
4.82
3.0
2.0
—
—
—
0
0
7
5
14.88
4.64
1.1
1.4
—
—
—
0
0
58
361
2.41
4.51
5.9
5.0
1.2
1.2
mmol/l
0.52
52
324
43
250
2.24
3.75
3.3
2.1
2.4
2.3
mmol/l
0.17
37
212
64
438
2.24
3.72
9.5
5.8
3.9
4.5
e9/l
1.32
55
381
59
398
2.14
3.47
3.4
3.7
0.0
0.0
estimate
0.00
16
58
58
389
2.14
3.46
3.4
3.7
0.0
0.0
estimate
0.00
15
62
80
611
2.43
3.43
5.2
4.0
14.9
15.0
pmol/l
0.18
71
548
30
156
2.31
3.36
2.8
2.5
10.7
4.9
e6/l
0.58
25
131
58
393
2.10
3.32
4.2
5.1
0.0
0.0
estimate
0.00
16
63
22
102
2.48
3.15
1.9
1.8
—
—
—
0
0
31
170
2.18
3.03
5.1
4.8
—
—
—
0
0
15
58
2.86
3.03
3.7
3.6
—
—
—
0
0
34
201
2.04
2.71
4.1
4.2
0.0
0.0
estimate
0.00
15
61
13
53
2.67
2.39
5.8
4.1
—
—
—
0
0
72
566
1.93
2.33
5.5
3.9
—
—
—
0
0
16
74
2.38
2.29
1.1
1.3
—
—
—
0
0
41
273
1.84
2.25
4.4
4.0
—
—
—
0
0
38
251
1.82
2.12
3.4
2.7
—
—
—
0
0
33
209
1.86
2.10
3.8
3.4
—
—
—
0
0
52
378
1.77
2.10
3.8
3.9
32.6
54.4
ng/l
0.96
35
275
44
305
1.78
2.08
3.1
3.6
—
—
—
0
0
55
407
1.76
2.08
7.0
5.1
0.2
0.2
e9/l
1.93
47
354
37
244
1.81
2.06
4.0
2.8
16.4
332.0
e6/l
0.59
31
178
14
64
2.38
2.05
1.1
1.2
—
—
—
0
0
32
202
1.85
2.05
2.8
2.1
3.4
2.8
mg/l
0.87
27
171
18
93
2.14
2.00
1.1
1.4
—
—
—
0
0
16
79
2.22
1.98
3.6
1.7
548.1
399.4
nmol/l
0.37
16
71
53
393
1.73
1.95
6.7
5.1
0.6
0.6
e9/l
0.05
45
339
92
808
2.41
1.94
21.9
13.0
22.3
24.4
mg/l
0.30
82
635
53
394
1.72
1.93
6.7
5.1
0.0
0.0
e9/l
0.66
45
343
40
275
1.75
1.92
3.4
2.9
7.3
7.5
mmol/l
0.09
31
232
9
35
2.72
1.85
2.0
2.1
229.3
1785.8
ug/l
—
9
30
5
12
4.32
1.84
1.0
1.2
104.0
56.0
pmol/l
—
5
12
13
61
2.30
1.80
5.7
3.4
5.1
5.1
kpa
0.03
13
54
53
400
1.68
1.78
6.7
5.2
1.8
1.9
e9/l
0.49
47
353
40
280
1.71
1.78
4.3
3.5
84.4
65.5
e6/l
0.18
33
195
47
344
1.68
1.77
13.8
8.3
1.2
1.3
inr
0.10
16
95
33
219
1.75
1.77
3.9
2.7
2.0
0.6
e6/l
0.33
27
152
86
745
1.98
1.74
6.3
4.8
2.1
1.9
mu/l
0.29
77
676
95
860
2.52
1.73
23.9
15.2
88.1
82.3
umol/l
0.36
95
860
89
781
2.10
1.72
4.9
4.4
1.3
1.3
mmol/l
0.35
82
717
17
94
1.97
1.59
2.8
2.2
1.9
1.6
%
0.44
17
84
33
226
1.68
1.56
3.9
2.4
347.1
9820.0
umol/l
1.54
27
191
12
58
2.21
1.56
4.8
3.8
0.6
0.9
%
—
5
16
43
317
1.62
1.53
4.0
2.7
200.6
122.7
ug/l
0.87
38
291
31
210
1.68
1.53
3.9
2.6
—
—
—
0
0
9
37
2.57
1.52
2.2
1.8
1.4
1.7
g/l
—
9
32
38
272
1.63
1.52
3.5
3.0
43.4
295.9
mg/l
0.54
27
174
9
39
2.43
1.47
2.3
1.8
—
—
—
0
0
9
39
2.43
1.47
1.7
1.2
—
—
—
0
0
40
292
1.61
1.47
4.9
3.8
11.5
8.6
mg/mmol
0.14
26
188
15
82
1.97
1.45
6.4
3.5
—
—
—
0
0
9
40
2.37
1.44
6.8
3.9
—
—
—
0
0
17
98
1.88
1.41
3.2
4.9
105.4
103.6
mmol/l
0.53
17
93
33
233
1.62
1.37
5.7
3.2
7.4
7.4
ph
0.07
11
38
92
836
2.02
1.30
22.3
12.7
—
—
—
0
0
90
816
1.88
1.22
5.5
4.9
4.5
4.5
mmol/l
0.02
83
761
26
179
1.61
1.19
1.7
1.3
—
—
—
0
0
90
819
1.84
1.16
5.8
4.8
6.4
6.0
mmol/l
0.77
81
748
89
809
1.79
1.13
5.5
4.8
1.5
1.5
mmol/l
0.02
82
749
5
21
2.45
1.10
2.8
1.8
—
—
—
0
0
5
21
2.45
1.10
1.6
2.4
—
—
—
0
0
81
721
1.60
1.09
19.1
13.6
37.8
39.6
%
0.75
48
483
46
367
1.46
1.06
7.7
5.1
2.5
2.9
%
0.83
40
341
41
320
1.47
1.06
5.8
3.9
2.6
2.0
ug/l
0.56
35
293
46
368
1.46
1.04
8.3
5.5
9.0
8.5
%
0.29
40
343
26
185
1.54
1.03
2.4
3.6
—
—
—
0
0
7
35
2.07
1.02
1.4
1.3
—
—
—
0
0
9
50
1.88
0.99
1.9
6.5
0.9
0.7
%
—
9
50
0
28
0.00
0.99
0.0
1.1
—
—
—
0
0
42
333
1.44
0.99
15.6
8.4
0.0
0.0
e9/l
0.49
33
256
9
51
1.84
0.97
1.9
6.4
1.7
1.6
%
—
9
51
46
375
1.41
0.92
8.0
5.3
27.2
26.7
%
0.10
40
348
29
217
1.47
0.91
1.5
1.5
23.7
20.5
nmol/l
0.26
21
189
90
834
1.67
0.87
5.9
5.4
2.6
2.6
mmol/l
0.02
83
773
66
581
1.39
0.80
5.2
3.9
—
—
—
0
0
43
354
1.37
0.79
8.0
5.0
0.6
0.7
%
0.23
38
328
6
34
1.81
0.77
1.5
3.6
—
—
—
0
0
7
40
1.80
0.73
1.6
1.3
—
—
—
0
0
26
199
1.41
0.72
1.6
1.8
393.3
460.0
pmol/l
0.78
20
163
17
120
1.50
0.70
1.7
1.7
—
—
—
0
0
44
370
1.33
0.68
7.9
5.1
56.0
58.1
%
0.40
38
346
27
210
1.39
0.68
8.5
3.8
—
—
—
0
0
5
28
1.82
0.67
4.6
3.5
—
—
—
0
0
23
175
1.41
0.66
4.7
2.6
1.0
0.7
ug/l
0.51
14
120
13
88
1.55
0.64
1.8
2.1
11.1
6.8
umol/l
0.30
13
74
32
260
1.34
0.62
7.9
4.8
—
—
—
0
0
83
777
1.37
0.54
7.4
6.7
42.5
40.9
mmol/mol
0.63
74
726
9
63
1.47
0.54
1.8
1.6
—
—
—
0
0
10
69
1.50
0.46
2.3
2.3
—
—
—
0
0
41
358
1.24
0.44
2.4
1.9
98.5
96.7
pmol/l
0.06
21
184
0
15
0.00
0.41
0.0
1.3
—
123.8
—
0
6
0
16
0.00
0.41
0.0
6.7
—
106.1
—
0
16
0
16
0.00
0.41
0.0
6.7
—
11.1
—
0
16
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
22
181
1.27
0.39
2.4
1.8
1191.2
1139.3
nmol/l
0.09
13
138
5
36
1.41
0.39
1.0
1.3
—
—
—
0
0
34
295
1.23
0.38
3.3
3.5
—
—
—
0
0
16
128
1.30
0.34
1.4
1.2
—
—
—
0
0
7
51
1.40
0.32
1.4
2.4
8.6
11.6
g/l
—
7
43
10
76
1.35
0.29
1.9
1.4
—
—
—
0
0
68
642
1.18
0.28
25.9
15.5
14.0
13.7
%
1.02
63
625
21
180
1.21
0.26
6.1
4.3
—
—
—
0
0
26
230
1.18
0.24
1.6
1.6
1.2
1.4
mmol/l
0.63
17
197
0
11
0.00
0.21
0.0
1.4
—
339.0
—
0
11
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
552.3
—
0
8
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
59
1.20
0.18
1.3
4.3
—
—
—
0
0
7
61
1.16
0.18
1.9
7.8
—
—
—
0
0
16
139
1.18
0.17
1.1
1.3
1.5
20.0
u/ml
—
7
57
9
78
1.17
0.16
2.7
3.1
142.4
224.7
ng/l
—
9
70
11
93
1.20
0.15
1.5
1.7
—
—
—
0
0
11
96
1.16
0.11
1.9
5.6
5.3
5.2
kpa
0.12
11
91
5
43
1.17
0.10
2.6
6.3
24.6
25.5
mmol/l
—
5
37
5
46
1.09
0.10
2.0
2.2
0.9
1.2
%
—
5
46
6
56
1.08
0.09
2.8
2.4
—
—
—
0
0
6
58
1.04
0.08
3.3
2.9
—
—
—
0
0
7
63
1.12
0.08
1.7
1.6
—
—
—
0
0
15
151
0.99
0.00
1.2
1.2
0.6
1.2
u/ml
—
5
45
9
96
0.93
0.00
2.2
3.7
—
—
—
0
0
5
51
0.98
0.00
5.2
5.5
24.7
24.9
mmol/l
—
5
51
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.8
1.4
—
—
—
0
0
6
68
0.88
0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
10.5
—
0
7
0
5
0.00
0.00
0.0
1.0
—
12.6
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
6
59
1.02
0.00
1.8
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
2791.7
—
0
6
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
6.1
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_NOS_EXALLC – Melanoma in situ, other sites/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).