No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
146 |
4. Check minimum number of eventsNone |
146 |
5. Include endpointsNone |
146 |
6. Filter based on genotype QC (FinnGen only) |
137 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Alia thrombocytopenia primaria
Similar endpoints
↥List of similar endpoints to
Other primary thrombocytopenia
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1180 | 637 | 530 |
| Only index persons | 901 | 512 | 389 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.63 | 48.40 | 57.23 |
| Only index persons | 45.98 | 40.32 | 53.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 137 | 82 | 55 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 50.24 | 39.64 | 66.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
169.8
128
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
493.0
81.4
74
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
68.2
60
*
XW000
NOMESCO Finland
Bone marrow biopsy
18.9
40.5
35
24
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
20.3
19
*
D64.9
ICD-10 Finland
Anaemia, unspecified
6.4
18.8
37
74
B02AA02
ATC
tranexamic acid; systemic
4.7
16.3
49
141
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
14.8
14
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
165.9
14.7
15
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
153.7
13.7
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.5
11.8
34
93
WW500
NOMESCO Finland
Blood transfusion
11.0
11.7
22
23
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
10.5
10
*
ZX120
NOMESCO Finland
Intravenous
4.2
9.2
27
74
6753
FHL
Transabdominal splenectomy
+∞
8.4
8
*
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
8.4
8
*
R04.0
ICD-10 Finland
Epistaxis
4.3
8.2
23
61
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
9.3
8.1
16
19
Z31.5
ICD-10 Finland
Genetic counselling
6.6
8.0
20
34
WX892
NOMESCO Finland
Monitored bed care
4.7
8.0
20
48
Z2221
NOMESCO Finland
Medical doctor
2.8
7.9
57
273
D70.89
ICD-10 Finland
Neutropenic splenomegaly
19.6
7.7
11
6
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
7.3
7
*
B02BX05
ATC
eltrombopag; oral
+∞
7.3
7
*
UJF32
NOMESCO Finland
Coloscopy
2.6
6.3
46
218
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
6.3
6
*
D69.0
ICD-10 Finland
Allergic purpura
+∞
6.3
6
*
2873C
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA ALIA DEFINITA]
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
6.2
78
474
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
6.0
39
174
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
61
180
5.10
20.18
3.3
2.2
12.63
14.68
umol/l
1.07
61
164
58
166
5.14
19.87
3.1
2.2
2.45
2.43
g/l
0.09
58
146
46
145
4.17
13.34
5.4
6.2
1.09
1.06
mmol/l
0.18
46
130
98
528
3.60
12.30
9.4
7.6
1.20
1.22
mmol/l
1.40
90
448
115
702
4.01
11.54
17.8
9.4
4.27
4.13
e9/l
0.24
107
622
22
25
10.15
11.25
4.9
1.8
—
—
—
0
0
23
50
5.27
10.42
2.0
2.0
1.27
1.42
g/l
0.27
17
42
62
294
2.93
8.94
3.8
3.1
341.42
4811.73
umol/l
1.30
55
251
59
283
2.82
8.21
3.2
1.8
3.11
2.98
mg/l
0.16
52
246
11
6
19.65
7.73
5.3
2.7
—
—
—
0
0
11
6
19.65
7.73
5.3
2.7
—
—
—
0
0
27
85
3.67
7.57
9.5
8.0
12.60
8.99
mmol/l
0.93
27
80
11
8
14.73
7.01
3.1
1.6
—
—
—
0
0
94
600
2.59
7.00
10.4
5.9
13.89
12.68
umol/l
0.24
94
567
17
40
4.68
6.96
2.0
2.4
—
—
—
0
0
76
449
2.44
6.56
7.9
4.8
35.42
35.87
g/l
0.31
71
422
6
0
+∞
6.29
1.2
0.0
—
—
—
0
0
23
74
3.50
6.21
14.4
6.5
23.53
24.79
mmol/l
0.87
23
74
72
425
2.37
6.11
2.7
1.9
98.18
95.93
pmol/l
0.12
44
210
17
35
5.36
5.97
1.1
1.3
—
—
—
0
0
80
505
2.29
5.69
16.7
12.1
1.10
1.24
inr
1.15
23
168
51
269
2.38
5.48
2.1
2.0
1.44
1.05
mg/l
0.53
38
208
15
30
5.45
5.43
2.1
2.9
0.00
0.00
g/l
-0.00
15
30
38
177
2.55
5.33
2.9
2.6
3.27
1.88
e6/l
0.41
17
94
30
130
2.65
4.83
12.2
7.7
104.57
104.36
mmol/l
0.09
30
130
49
268
2.25
4.75
4.2
2.0
—
—
—
0
0
27
112
2.73
4.73
8.0
11.9
-0.67
1.77
mmol/l
1.28
19
90
38
189
2.37
4.58
2.9
2.5
3.93
0.88
e6/l
0.71
18
105
56
330
2.13
4.47
4.3
2.8
1.52
0.42
e6/l
0.59
42
242
39
204
2.24
4.15
2.8
3.2
52.69
155.90
ng/l
0.98
34
149
77
530
1.96
3.87
4.4
2.6
—
—
—
0
0
6
5
12.43
3.79
1.0
6.4
116.33
103.40
%
—
6
5
20
81
2.70
3.65
3.4
4.4
138.50
72.39
ng/l
0.48
20
70
10
21
5.03
3.63
1.0
1.5
—
—
—
0
0
16
58
2.98
3.55
1.7
1.7
—
—
—
0
0
13
42
3.30
3.46
2.1
1.9
0.23
0.24
g/l
0.08
13
42
10
24
4.39
3.26
1.1
1.3
—
—
—
0
0
111
896
2.00
3.17
4.2
3.9
14.61
14.76
pmol/l
0.22
105
808
13
45
3.07
3.11
2.1
1.9
1.11
1.17
g/l
0.26
13
45
56
373
1.81
2.92
4.7
3.1
40.30
29.67
u/l
0.42
50
358
10
28
3.76
2.84
2.7
1.9
—
—
—
0
0
8
18
4.64
2.84
1.6
1.7
—
—
—
0
0
59
405
1.77
2.75
4.9
3.0
—
—
—
0
0
6
10
6.20
2.72
1.0
1.3
—
—
—
0
0
6
10
6.20
2.72
1.0
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
30
3.50
2.66
4.7
2.9
0.19
0.33
u/ml
—
5
14
9
25
3.77
2.62
2.7
1.5
—
—
—
0
0
8
21
3.97
2.50
8.0
4.6
66.25
55.76
%
—
8
21
8
21
3.97
2.50
1.5
1.7
12955.63
5793.87
e6/l
—
8
15
23
121
2.07
2.37
2.4
1.6
—
—
—
0
0
23
123
2.03
2.27
2.4
1.7
—
—
—
0
0
5
9
5.71
2.23
1.4
1.1
—
—
—
0
0
124
1086
1.94
2.18
25.7
12.1
79.55
83.11
ml/min/173m2
0.75
105
880
11
43
2.68
2.13
10.4
4.0
0.53
0.72
%
0.91
11
43
16
76
2.24
2.11
2.8
1.5
—
—
—
0
0
7
20
3.62
2.08
1.4
1.2
—
—
—
0
0
130
1163
2.07
2.06
29.1
13.2
21.86
21.82
mg/l
0.01
117
916
30
183
1.80
2.02
2.4
1.8
—
—
—
0
0
94
771
1.62
2.02
3.4
3.0
57.56
42.98
u/l
0.76
89
727
16
78
2.18
1.99
3.0
5.5
0.38
1.21
mmol/l
—
9
58
7
21
3.45
1.99
1.4
1.3
—
—
—
0
0
20
108
1.99
1.93
3.2
4.6
2.75
10.27
ug/l
1.02
13
82
11
46
2.50
1.90
1.3
1.5
—
—
—
0
0
5
12
4.27
1.84
1.2
1.3
—
—
—
0
0
11
47
2.45
1.82
10.4
3.9
1.45
1.16
%
0.26
11
47
7
23
3.14
1.82
2.0
1.3
—
—
—
0
0
8
29
2.86
1.82
1.3
1.3
—
—
—
0
0
7
24
3.01
1.74
2.4
1.5
—
—
—
0
0
5
14
3.66
1.63
1.4
1.1
—
—
—
0
0
8
32
2.58
1.62
2.1
1.3
—
—
—
0
0
5
15
3.41
1.53
1.2
1.3
—
—
—
0
0
6
22
2.80
1.45
2.0
1.4
—
—
—
0
0
6
22
2.80
1.45
2.0
1.4
—
—
—
0
0
50
380
1.48
1.38
4.1
3.1
2.31
2.36
mmol/l
1.42
41
334
9
42
2.22
1.36
2.4
2.4
—
—
—
0
0
29
197
1.59
1.33
2.7
3.0
2.42
2.46
mmol/l
0.78
21
171
44
329
1.48
1.31
5.0
3.8
6.96
9.87
mg/mmol
0.43
36
204
8
34
2.43
1.31
2.1
1.4
—
—
—
0
0
137
1292
1.98
1.29
48.5
19.8
39.02
40.28
%
2.46
128
1226
8
36
2.29
1.26
1.5
1.6
—
—
—
0
0
6
25
2.46
1.25
2.2
2.3
16.23
16.34
%
—
6
9
16
95
1.77
1.19
3.3
3.6
1.23
1.22
mmol/l
0.18
16
83
54
428
1.42
1.18
4.5
3.6
58.84
36.30
ng/l
0.50
39
281
8
39
2.11
1.17
1.1
1.7
0.56
8.53
ug/l
—
8
34
5
20
2.55
1.16
2.8
1.5
—
—
—
0
0
28
195
1.54
1.16
1.3
1.3
1.95
6.94
u/ml
1.28
11
77
69
573
1.39
1.14
4.8
3.7
0.00
0.00
estimate
-0.00
17
126
5
21
2.43
1.10
2.0
1.5
—
—
—
0
0
117
1067
1.49
1.09
4.2
3.9
1.40
1.25
mmol/l
0.85
110
974
69
578
1.37
1.06
4.8
3.8
0.00
0.00
estimate
-0.00
15
115
7
35
2.05
1.01
1.9
1.5
—
—
—
0
0
68
572
1.35
1.01
6.8
5.1
0.00
0.00
estimate
-0.00
17
121
121
1117
1.49
1.00
4.4
4.3
4.40
4.63
mmol/l
1.62
114
1032
5
23
2.21
0.99
1.8
1.3
—
—
—
0
0
29
211
1.47
0.98
1.3
1.3
74.59
30.67
iu/ml
—
9
71
6
31
1.97
0.85
1.0
1.2
—
—
—
0
0
6
31
1.97
0.85
1.0
1.2
—
—
—
0
0
6
31
1.97
0.85
1.2
1.1
—
—
—
0
0
11
65
1.75
0.85
1.5
1.2
—
—
—
0
0
8
46
1.78
0.84
2.5
3.7
38.14
47.42
%
—
8
46
6
33
1.85
0.80
2.2
1.7
—
—
—
0
0
119
1111
1.38
0.77
4.5
4.3
1.34
1.48
mmol/l
3.36
111
1015
7
38
1.88
0.74
1.3
1.2
—
—
—
0
0
7
40
1.79
0.72
2.0
1.5
—
—
—
0
0
5
26
1.95
0.71
1.2
1.2
—
—
—
0
0
8
127
0.61
0.67
1.4
1.8
—
—
—
0
0
8
122
0.64
0.57
6.9
7.1
—
—
—
0
0
22
169
1.36
0.57
2.9
3.1
0.72
0.71
ug/l
0.02
16
117
9
61
1.51
0.55
1.2
1.3
—
—
—
0
0
112
1054
1.27
0.55
6.3
5.5
39.15
39.69
mmol/mol
0.24
106
987
13
92
1.45
0.52
2.2
1.7
—
—
—
0
0
7
49
1.45
0.46
1.7
2.0
—
—
—
0
0
7
49
1.45
0.46
1.6
3.0
25.47
25.12
mmol/l
—
7
49
15
113
1.36
0.45
3.9
3.4
—
—
—
0
0
8
57
1.43
0.43
3.8
6.3
23.06
24.51
mmol/l
—
8
57
19
152
1.29
0.39
1.6
2.0
—
—
—
0
0
6
42
1.45
0.36
1.5
1.8
—
—
—
0
0
10
73
1.40
0.35
1.5
1.5
—
—
—
0
0
6
44
1.38
0.35
1.5
1.6
—
—
—
0
0
10
74
1.38
0.33
2.2
1.6
—
—
—
0
0
6
47
1.29
0.32
1.5
1.9
—
—
—
0
0
30
261
1.19
0.31
1.9
1.6
—
—
—
0
0
7
56
1.26
0.30
1.1
1.0
—
—
—
0
0
8
66
1.22
0.27
1.4
4.0
4.67
4.55
pmol/l
—
8
57
112
1092
1.11
0.17
5.0
4.4
5.84
5.91
mmol/l
0.25
101
991
19
211
0.89
0.14
1.4
1.4
—
—
—
0
0
85
824
1.08
0.13
3.8
3.3
—
—
—
0
0
5
43
1.17
0.10
1.6
1.5
—
—
—
0
0
5
43
1.17
0.10
1.6
1.5
—
—
—
0
0
5
43
1.17
0.10
1.6
1.5
—
—
—
0
0
15
137
1.11
0.08
1.5
1.9
—
—
—
0
0
25
239
1.06
0.04
3.8
4.3
22.13
21.93
%
—
8
127
33
321
1.04
0.02
5.8
3.9
0.00
0.00
estimate
-0.00
16
116
45
446
1.01
0.00
4.8
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
25.20
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
54.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.493 [1.72, 3.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.598 [1.6, 4.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHPRIMTHROMBOCYTOPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.238% | 0.479% |
| 5 | 1.336% | 2.855% |
| 10 | 3.226% | 6.937% |
| 15 | 6.591% | 13.331% |
| 20 | 11.845% | 21.59% |
Relationships between endpoints
↥Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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