No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Alia thrombocytopenia primaria
Similar endpoints
↥List of similar endpoints to
Other primary thrombocytopenia
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1180 | 637 | 530 |
| Only index persons | 901 | 512 | 389 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.63 | 48.40 | 57.23 |
| Only index persons | 45.98 | 40.32 | 53.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 82 | 56 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 49.90 | 39.64 | 64.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 125
- Matched controls
- 1249
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
146.1
110
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
1309.6
74.2
65
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
54.2
48
*
XW000
NOMESCO Finland
Bone marrow biopsy
19.2
20.3
31
21
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
16.0
15
*
B02AA02
ATC
tranexamic acid; systemic
5.7
13.6
44
109
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
71.9
11.8
13
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
+∞
11.6
11
*
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
11.6
11
*
D64.9
ICD-10 Finland
Anaemia, unspecified
6.9
11.3
29
52
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
9.5
9
*
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
8.4
8
*
6753
FHL
Transabdominal splenectomy
+∞
8.4
8
*
WW500
NOMESCO Finland
Blood transfusion
8.2
8.3
18
25
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
11.2
8.3
15
15
D70.89
ICD-10 Finland
Neutropenic splenomegaly
23.9
8.2
11
5
B02BX05
ATC
eltrombopag; oral
+∞
7.4
7
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
7.4
7
*
ZX120
NOMESCO Finland
Intravenous
4.6
7.0
24
61
Z31.5
ICD-10 Finland
Genetic counselling
7.2
6.9
16
25
A02BC01
ATC
omeprazole; systemic
3.0
6.5
44
193
D69.0
ICD-10 Finland
Allergic purpura
+∞
6.3
6
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
6.3
6
*
2873C
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA ALIA DEFINITA]
+∞
6.3
6
*
M04AA01
ATC
allopurinol; systemic
4.2
6.2
23
63
R04.0
ICD-10 Finland
Epistaxis
5.4
6.2
18
38
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
23
10.59
17.79
5.0
1.9
—
—
—
0
0
54
159
4.94
17.77
3.3
2.1
2.5
2.5
g/l
0.02
54
138
45
134
4.50
14.26
5.5
6.3
1.1
1.1
mmol/l
0.19
45
122
91
496
3.45
11.01
9.7
7.8
1.2
1.2
mmol/l
1.41
83
419
107
661
3.75
10.24
18.6
9.7
4.3
4.1
e9/l
0.24
102
588
17
31
6.11
9.23
1.1
1.3
—
—
—
0
0
20
44
5.15
8.92
2.1
2.1
1.2
1.4
g/l
0.28
15
37
59
280
2.93
8.53
3.9
3.1
342.9
4155.9
umol/l
1.05
53
236
11
5
23.70
8.15
5.3
3.0
—
—
—
0
0
11
5
23.70
8.15
5.3
3.0
—
—
—
0
0
14
24
6.38
8.03
2.1
3.2
0.0
0.0
g/l
0.00
14
24
55
266
2.78
7.51
3.3
1.8
3.2
3.0
mg/l
0.18
49
232
16
34
5.19
7.37
2.1
2.6
—
—
—
0
0
11
8
14.79
7.02
3.1
1.6
—
—
—
0
0
89
568
2.60
6.66
10.6
6.0
14.2
12.6
umol/l
0.31
89
538
22
67
3.72
6.46
15.0
7.1
23.7
25.0
mmol/l
0.82
22
67
6
0
+∞
6.29
1.2
0.0
—
—
—
0
0
71
424
2.39
5.92
8.3
4.8
35.1
36.0
g/l
0.68
66
400
68
403
2.36
5.72
2.7
1.9
96.5
96.0
pmol/l
0.03
41
203
48
250
2.41
5.35
4.3
2.0
—
—
—
0
0
36
164
2.62
5.31
3.1
2.5
3.3
1.5
e6/l
0.60
17
89
26
104
2.85
4.90
8.2
12.6
-0.5
2.1
mmol/l
1.27
18
82
47
252
2.31
4.84
2.1
2.1
1.4
1.0
mg/l
0.50
34
196
10
21
5.06
4.61
1.0
1.5
—
—
—
0
0
36
176
2.41
4.53
3.1
2.4
3.9
0.8
e6/l
0.72
18
100
53
310
2.15
4.35
4.4
2.8
1.6
0.4
e6/l
0.61
41
227
37
192
2.27
4.04
2.9
3.2
52.1
165.7
ng/l
1.02
32
138
13
38
3.67
4.01
2.1
2.0
0.2
0.2
g/l
0.13
13
38
10
24
4.41
3.96
1.1
1.3
—
—
—
0
0
6
5
12.45
3.80
1.0
6.4
116.3
103.4
%
—
6
5
11
30
3.90
3.72
2.4
2.2
555.4
339.4
ug/l
0.23
11
30
19
75
2.78
3.64
3.5
4.1
144.2
68.1
ng/l
0.54
19
66
13
41
3.40
3.60
2.1
2.0
1.1
1.2
g/l
0.31
13
41
10
26
4.07
3.59
2.7
1.8
—
—
—
0
0
72
498
1.93
3.55
7.1
4.2
—
—
—
0
0
15
54
2.99
3.38
1.7
1.6
—
—
—
0
0
10
29
3.64
3.11
2.5
2.6
22.4
23.9
mmol/l
—
10
23
57
381
1.85
2.99
5.0
2.9
—
—
—
0
0
8
17
4.92
2.96
1.6
1.8
—
—
—
0
0
9
22
4.30
2.94
2.7
1.5
—
—
—
0
0
6
9
6.91
2.90
1.0
1.0
—
—
—
0
0
104
849
1.91
2.73
4.2
3.9
14.6
14.8
pmol/l
0.33
99
768
6
10
6.21
2.72
1.0
1.3
—
—
—
0
0
53
356
1.79
2.69
4.7
3.1
41.5
29.1
u/l
0.48
47
342
22
113
2.13
2.42
2.5
1.6
—
—
—
0
0
7
17
4.28
2.39
1.4
1.1
—
—
—
0
0
22
115
2.09
2.32
2.5
1.7
—
—
—
0
0
91
732
1.71
2.31
3.4
3.0
59.0
43.7
u/l
0.78
86
690
7
18
4.04
2.28
1.4
1.4
—
—
—
0
0
5
9
5.71
2.23
1.4
1.1
—
—
—
0
0
13
55
2.51
2.19
8.8
4.0
118.1
130.2
g/l
1.40
13
55
29
172
1.87
2.15
2.4
1.8
—
—
—
0
0
116
1019
1.87
1.95
26.6
12.1
79.2
83.3
ml/min/173m2
0.88
100
820
16
79
2.16
1.94
3.4
5.5
4.8
5.0
kpa
0.89
16
73
7
22
3.29
1.90
2.4
1.5
—
—
—
0
0
11
46
2.51
1.90
10.4
3.6
1.5
1.2
%
0.26
11
46
8
28
2.97
1.89
1.3
1.3
—
—
—
0
0
19
102
2.00
1.87
3.3
4.7
2.7
6.6
ug/l
0.96
13
78
5
12
4.28
1.84
1.2
1.3
—
—
—
0
0
15
74
2.15
1.83
3.1
5.7
0.4
1.0
mmol/l
—
8
55
115
1016
1.79
1.78
36.5
14.1
39.2
40.1
%
0.93
92
763
15
75
2.12
1.77
2.9
1.5
—
—
—
0
0
8
30
2.77
1.75
2.1
1.4
—
—
—
0
0
122
1103
1.91
1.66
30.1
13.3
21.5
21.7
mg/l
0.03
109
868
8
32
2.59
1.62
2.1
1.4
—
—
—
0
0
5
15
3.42
1.53
1.2
1.3
—
—
—
0
0
9
39
2.40
1.46
2.6
2.5
—
—
—
0
0
6
22
2.80
1.45
2.2
1.3
—
—
—
0
0
5
18
2.84
1.29
2.8
1.6
—
—
—
0
0
47
359
1.47
1.28
4.3
3.1
2.3
2.4
mmol/l
1.36
37
313
42
315
1.48
1.24
3.5
2.0
1016.0
236.5
u/l
0.51
42
297
5
19
2.69
1.22
2.0
1.5
—
—
—
0
0
27
185
1.57
1.20
1.3
1.3
1.9
7.3
u/ml
—
10
71
11
58
1.97
1.15
1.5
1.2
—
—
—
0
0
65
538
1.39
1.11
5.0
3.7
0.0
0.0
estimate
0.00
14
113
111
1012
1.49
1.06
4.2
3.9
1.4
1.3
mmol/l
0.83
106
929
9
46
2.02
1.06
1.3
1.5
—
—
—
0
0
28
200
1.50
1.04
1.4
1.3
74.6
31.2
iu/ml
—
9
69
7
34
2.11
1.04
1.4
1.5
—
—
—
0
0
5
22
2.32
1.04
2.4
2.5
15.5
16.3
%
—
5
8
115
1058
1.52
1.03
4.4
4.3
4.4
4.6
mmol/l
1.45
109
980
50
401
1.39
1.01
4.7
3.6
58.8
35.9
ng/l
0.50
39
262
65
545
1.36
1.00
5.0
3.7
0.0
0.0
estimate
0.00
15
109
26
186
1.49
0.96
3.0
3.1
2.4
2.5
mmol/l
0.68
19
160
7
37
1.94
0.95
2.0
1.5
—
—
—
0
0
64
539
1.35
0.95
7.1
5.0
0.0
0.0
estimate
0.00
15
114
6
28
2.19
0.92
1.0
1.2
—
—
—
0
0
6
28
2.19
0.92
1.2
1.1
—
—
—
0
0
6
28
2.19
0.92
1.0
1.2
—
—
—
0
0
8
44
1.87
0.87
2.5
3.6
38.1
47.9
%
—
8
44
14
90
1.62
0.82
3.6
3.7
1.2
1.2
mmol/l
0.16
14
79
113
1053
1.40
0.77
4.5
4.2
1.3
1.5
mmol/l
3.03
107
965
5
23
2.22
0.77
1.8
1.3
—
—
—
0
0
9
55
1.68
0.75
1.2
1.3
—
—
—
0
0
7
116
0.58
0.71
7.7
7.2
—
—
—
0
0
5
30
1.69
0.62
2.4
1.6
—
—
—
0
0
6
35
1.75
0.58
1.8
1.5
—
—
—
0
0
8
54
1.51
0.58
3.8
6.6
23.1
24.3
mmol/l
—
8
54
8
123
0.63
0.58
1.4
1.8
—
—
—
0
0
6
38
1.60
0.55
1.3
1.2
—
—
—
0
0
6
40
1.52
0.52
1.5
1.8
—
—
—
0
0
7
47
1.52
0.48
1.7
2.1
—
—
—
0
0
12
87
1.42
0.44
2.3
1.7
—
—
—
0
0
105
998
1.22
0.40
6.4
5.6
39.0
39.7
mmol/mol
0.33
100
939
14
107
1.34
0.39
4.1
3.4
—
—
—
0
0
9
71
1.29
0.37
1.4
1.5
—
—
—
0
0
9
71
1.29
0.37
2.2
1.6
—
—
—
0
0
20
163
1.27
0.36
3.0
3.0
0.7
0.7
ug/l
0.07
15
113
6
45
1.35
0.34
1.5
2.0
—
—
—
0
0
29
251
1.20
0.32
1.9
1.6
—
—
—
0
0
8
64
1.27
0.28
1.4
4.0
4.7
4.6
pmol/l
—
8
55
17
145
1.20
0.22
1.7
2.1
—
—
—
0
0
5
42
1.20
0.21
1.6
1.5
—
—
—
0
0
5
42
1.20
0.21
1.6
1.5
—
—
—
0
0
5
42
1.20
0.21
1.6
1.5
—
—
—
0
0
81
785
1.08
0.13
3.9
3.3
—
—
—
0
0
5
43
1.17
0.10
1.6
1.6
—
—
—
0
0
105
1032
1.07
0.09
5.0
4.4
5.8
5.9
mmol/l
0.50
95
941
6
55
1.09
0.09
1.2
1.0
—
—
—
0
0
19
201
0.94
0.05
1.4
1.4
—
—
—
0
0
30
299
1.00
0.00
6.2
3.9
0.0
0.0
estimate
0.00
14
109
42
421
1.00
0.00
5.1
3.8
—
—
—
0
0
23
232
0.99
0.00
3.9
4.2
22.1
21.9
%
—
8
123
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
13
130
1.00
0.00
1.6
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.493 [1.72, 3.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.598 [1.6, 4.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHPRIMTHROMBOCYTOPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.238% | 0.479% |
| 5 | 1.336% | 2.855% |
| 10 | 3.226% | 6.937% |
| 15 | 6.591% | 13.331% |
| 20 | 11.845% | 21.59% |
Relationships between endpoints
↥Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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