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Hypothyroidism, autoimmune, DX-based

Endpoint Browser PheWeb

E4_HYTHY_AI_DX

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • E4_THYROIDITAUTOIM
706

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E03.80
  • Cause of death: ICD-10 — E03.80

2 out of 7 registries used, show all original rules.

138

4. Check minimum number of events

None

138

5. Include endpoints

None

138

6. Filter based on genotype QC (FinnGen only)

138

Control definitions (FinnGen only)

Control conditions
not E4_THYROIDITAUTOIM

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1013 858 154
Only index persons 972 826 146
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.00
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 25.77 27.49 15.90
Only index persons 26.47 28.23 16.49

-FinnGen-

Key figures

All Female Male
Number of individuals 138 125 13
Unadjusted period prevalence (%) 0.04 0.04 0.01
Median age at first event (years) 40.89 40.78 41.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
125
Matched controls
1248
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
9971.0
163.2
120
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
8490.9
157.7
124
15
H03AA01
ATC
levothyroxine sodium; systemic
300.3
80.6
123
211
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
13.3
34.0
70
109
104
Kela drug reimbursment
Thyroid insufficiency
18.2
30.6
50
44
E03.89
ICD-10 Finland
Other specified hypothyroidism
14.5
14.3
24
20
E03
ICD-10 Finland
Other hypothyroidism
7.4
10.7
26
43
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.9
10.5
17
13
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
12.0
9.1
16
15
T86
ICPC
Hypothyroidism/myxoedema
9.6
8.6
17
20
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
7.2
8.4
20
32
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
23.9
8.2
11
5
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.5
8.0
15
16
XCK10
NOMESCO Finland
Photography of fundus of eye
6.1
7.5
20
38
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
9.7
7.3
14
16
H3600, E103
ICD-10 Finland
NA
42.4
6.8
8
*
A10AA01
ATC
NA
13.2
6.7
11
9
A10AE05
ATC
insulin detemir; parenteral
5.8
6.6
18
35
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
15.4
6.5
10
7
A10AA02
ATC
NA
11.9
6.4
11
10
A10AE04
ATC
insulin glargine; parenteral
5.1
6.3
19
42
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
6.3
6
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.0
6.2
19
43

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
92
10.15
38.62
4.4
3.5
4.4
4.8
pmol/l
1.37
52
78
39
126
3.92
10.80
1.5
1.2
399.5
191.6
iu/ml
1.57
27
48
44
171
3.31
9.07
2.0
1.5
545.9
446.7
titre
0.13
17
36
20
47
4.81
8.25
2.0
1.7
3.9
10.0
iu/l
—
9
14
99
668
2.71
6.56
7.2
9.4
3.7
4.0
e9/l
0.55
88
596
49
242
2.59
6.24
1.5
1.3
18.8
21.3
iu/ml
0.13
15
72
67
386
2.43
6.11
4.3
4.1
36.5
36.7
g/l
0.11
62
368
60
338
2.37
5.66
1.8
1.3
4.6
1.1
u/ml
0.52
22
93
111
851
2.56
4.71
5.8
3.6
11.0
9.4
mm/h
0.77
102
784
16
49
3.56
4.63
2.4
1.5
0.2
0.2
g/l
1.01
16
49
45
241
2.29
4.62
1.6
1.3
5.4
5.4
u/ml
0.00
17
102
86
601
2.14
4.45
6.3
6.3
0.2
0.2
e9/l
0.08
80
545
12
31
4.14
4.36
1.4
1.2
—
—
—
0
0
94
685
2.17
4.29
3.0
3.0
—
—
—
0
0
82
577
2.04
4.00
6.2
6.1
0.5
0.5
e9/l
0.52
75
514
82
580
2.02
3.91
6.2
6.1
0.0
0.0
e9/l
0.18
75
515
42
235
2.13
3.79
6.4
3.5
1.8
15.1
mg/mmol
2.84
30
127
55
342
2.01
3.74
2.2
3.0
2.3
2.4
mmol/l
0.71
48
303
19
75
2.78
3.64
3.9
3.0
—
—
—
0
0
68
464
1.92
3.47
3.6
3.0
—
—
—
0
0
43
251
2.04
3.44
3.7
3.3
1.0
1.0
kg/l
—
6
29
39
221
2.07
3.37
5.5
2.9
15.1
87.4
mg/l
2.48
26
124
65
441
1.90
3.34
6.3
5.5
1.2
1.2
mmol/l
1.17
60
402
54
346
1.92
3.29
1.8
2.0
—
—
—
0
0
104
830
2.03
3.19
5.6
3.9
—
—
—
0
0
84
628
1.86
3.11
4.4
3.8
7.0
6.2
mmol/l
2.25
76
552
43
260
1.95
3.08
4.0
3.3
—
—
—
0
0
32
174
2.09
3.06
1.5
1.6
465.5
470.9
pmol/l
0.02
27
151
48
303
1.90
3.02
1.6
1.4
1.8
2.0
g/l
0.81
21
191
131
1179
3.19
2.98
14.9
10.4
14.7
18.1
mg/l
1.10
112
877
75
546
1.82
2.98
6.5
5.8
2.7
2.8
%
0.14
70
517
12
41
3.11
2.94
1.4
2.9
—
—
—
0
0
73
529
1.81
2.93
6.8
5.9
0.8
0.7
%
0.78
68
499
10
31
3.40
2.83
1.2
1.2
306.2
329.4
ug/g
—
5
14
5
6
8.58
2.77
1.6
1.2
19.3
25.3
mg/l
—
5
6
31
173
2.02
2.76
1.5
1.5
—
—
—
0
0
47
303
1.84
2.73
5.9
6.8
—
—
—
0
0
24
123
2.15
2.66
1.6
1.3
—
—
—
0
0
49
323
1.80
2.64
4.0
6.7
1.2
1.1
inr
—
7
107
48
316
1.80
2.59
2.8
3.0
19.6
19.7
ng/l
0.01
28
169
7
16
4.55
2.51
1.1
1.6
—
—
—
0
0
6
13
4.77
2.29
1.7
1.6
—
—
—
0
0
12
48
2.64
2.25
3.1
2.6
—
—
—
0
0
5
9
5.71
2.23
1.2
1.7
1.9
1.9
mmol/l
—
5
9
21
110
2.07
2.20
1.9
2.2
23.1
22.2
%
0.07
14
96
7
19
3.82
2.18
2.0
1.2
—
—
—
0
0
6
14
4.43
2.17
2.2
2.1
—
—
—
0
0
9
31
3.03
2.11
1.2
1.9
381.8
340.3
mg/l
—
9
31
53
377
1.66
2.10
3.5
3.6
14.5
67.6
e6/l
2.26
36
248
8
26
3.20
2.05
3.1
3.5
—
—
—
0
0
41
274
1.71
2.05
5.3
3.7
7.4
7.4
ph
—
5
54
48
336
1.66
2.01
2.8
2.6
—
—
—
0
0
46
321
1.65
1.94
1.7
1.8
—
—
—
0
0
16
80
2.13
1.89
4.6
6.5
-0.2
1.2
mmol/l
0.66
11
62
47
333
1.62
1.86
2.4
2.2
46.6
54.7
u/l
1.95
42
311
22
125
1.90
1.85
2.0
2.1
2.5
2.5
g/l
0.27
17
113
7
23
3.15
1.82
1.4
1.1
—
—
—
0
0
7
163
0.40
1.81
1.0
1.3
—
—
—
0
0
10
41
2.55
1.80
5.7
5.0
—
—
—
0
0
7
25
2.89
1.67
1.1
2.0
—
—
—
0
0
67
528
1.52
1.63
8.5
8.8
0.0
0.0
e9/l
0.49
54
439
73
586
1.52
1.63
4.0
3.2
0.0
0.0
estimate
—
6
120
5
14
3.66
1.63
1.4
2.3
—
—
—
0
0
10
44
2.37
1.57
1.7
1.5
—
—
—
0
0
38
266
1.59
1.56
3.9
3.1
—
—
—
0
0
41
293
1.57
1.54
3.0
2.8
54.6
39.2
e6/l
0.12
31
222
5
15
3.42
1.53
1.0
1.0
—
—
—
0
0
38
267
1.58
1.53
3.1
3.5
101.6
94.6
%
1.04
38
261
117
1052
1.74
1.52
18.6
13.4
331.7
332.2
g/l
0.29
117
1047
120
1087
1.80
1.51
4.6
3.8
1.5
1.5
mmol/l
0.17
114
1012
18
103
1.86
1.49
1.5
1.4
—
—
—
0
0
37
260
1.58
1.49
1.7
2.0
0.7
1.1
mg/l
0.52
28
189
121
1101
1.80
1.47
5.0
4.1
2.9
2.8
mmol/l
0.55
115
1021
5
16
3.20
1.45
2.8
2.9
154.5
86.1
ug/min
—
5
10
10
46
2.27
1.43
4.4
6.7
96.8
95.6
%
—
10
46
22
136
1.73
1.43
2.1
2.1
12.5
13.9
umol/l
0.46
16
120
38
273
1.54
1.38
3.0
2.7
0.0
0.3
e6/l
3.67
27
205
5
17
3.01
1.37
1.2
1.2
—
—
—
0
0
21
130
1.73
1.36
1.2
1.1
—
—
—
0
0
24
156
1.65
1.31
3.2
3.3
35.6
218.4
ng/l
0.81
13
93
76
635
1.44
1.28
3.5
2.7
58.5
63.6
ug/l
0.37
70
590
72
596
1.44
1.28
5.4
4.6
0.0
0.0
estimate
—
6
120
8
36
2.30
1.26
1.0
1.0
—
—
—
0
0
49
378
1.46
1.26
5.7
5.6
—
—
—
0
0
8
37
2.23
1.23
1.0
1.1
—
1.7
—
0
6
72
601
1.41
1.20
4.0
3.3
0.0
0.0
estimate
—
6
118
28
194
1.56
1.19
2.1
2.4
110.4
96.6
ug/g
0.17
16
143
41
309
1.47
1.18
4.2
3.4
0.0
0.0
estimate
—
5
122
14
81
1.81
1.14
1.5
1.3
529.9
451.3
u/ml
0.06
14
75
29
205
1.52
1.13
3.0
3.6
—
—
—
0
0
114
1043
1.53
1.09
4.1
3.4
1.2
1.2
mmol/l
0.21
106
966
16
98
1.72
1.09
5.1
4.2
—
—
—
0
0
9
46
2.02
1.06
3.8
2.9
26.1
24.0
mmol/l
—
9
46
18
115
1.65
1.06
1.2
1.4
—
—
—
0
0
131
1245
2.03
1.05
13.5
9.3
—
—
—
0
0
9
47
1.98
1.04
2.2
1.7
—
—
—
0
0
21
141
1.58
1.02
1.5
1.5
994.1
1091.9
nmol/l
0.26
16
103
36
272
1.44
1.02
2.4
2.2
2.7
2.8
mg/l
0.16
31
222
12
70
1.78
0.96
1.3
1.4
—
—
—
0
0
16
102
1.64
0.95
1.4
1.7
—
—
—
0
0
10
55
1.88
0.95
6.4
3.5
—
—
—
0
0
116
1077
1.48
0.90
4.4
3.8
6.1
5.6
mmol/l
1.94
110
992
8
42
1.96
0.90
1.6
2.1
—
—
—
0
0
20
139
1.51
0.85
1.2
1.2
—
—
—
0
0
22
158
1.47
0.81
1.5
2.4
2.4
2.4
mmol/l
0.33
16
143
5
23
2.22
0.77
1.2
1.3
—
—
—
0
0
9
56
1.65
0.74
2.2
1.8
—
—
—
0
0
5
25
2.04
0.73
2.0
2.0
—
—
—
0
0
35
279
1.34
0.72
3.1
2.6
—
—
—
0
0
5
27
1.88
0.69
1.8
2.1
—
—
—
0
0
12
78
1.59
0.68
1.8
1.5
—
—
—
0
0
45
377
1.29
0.65
2.0
1.8
99.2
99.2
pmol/l
0.00
30
189
6
101
0.58
0.65
1.5
1.5
—
—
—
0
0
8
50
1.64
0.62
1.6
1.1
—
—
—
0
0
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
11
74
1.53
0.55
2.8
6.8
—
—
—
0
0
53
464
1.23
0.52
2.2
1.8
—
—
—
0
0
12
84
1.47
0.51
1.8
1.5
—
—
—
0
0
12
84
1.47
0.51
1.8
1.5
—
—
—
0
0
12
85
1.45
0.48
1.8
1.5
—
—
—
0
0
26
211
1.29
0.48
1.5
1.5
—
—
—
0
0
36
305
1.24
0.47
4.6
4.5
—
—
—
0
0
5
32
1.58
0.42
1.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
5.1
—
70.1
—
0
16
44
387
1.20
0.41
2.4
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
5.1
—
—
—
0
0
5
35
1.44
0.39
7.6
5.5
—
—
—
0
0
5
36
1.40
0.38
18.2
7.2
—
—
—
0
0
5
36
1.40
0.38
1.4
1.2
—
—
—
0
0
9
69
1.33
0.38
1.6
1.3
—
—
—
0
0
10
72
1.42
0.38
1.8
1.4
—
—
—
0
0
9
71
1.29
0.37
1.8
2.5
—
—
—
0
0
16
129
1.27
0.32
1.1
1.2
—
—
—
0
0
38
424
0.86
0.30
2.0
1.7
—
—
—
0
0
7
56
1.26
0.30
4.1
3.7
138.9
130.4
g/l
—
7
56
11
85
1.32
0.29
1.6
1.5
—
—
—
0
0
5
38
1.33
0.23
1.2
1.9
—
—
—
0
0
10
79
1.29
0.23
1.3
1.1
—
—
—
0
0
11
89
1.26
0.21
3.4
5.1
2.5
1.6
mmol/l
0.95
11
65
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
0.2
—
0
7
0
14
0.00
0.20
0.0
15.2
—
823.4
—
0
14
0
14
0.00
0.20
0.0
20.1
—
1533.6
—
0
14
7
58
1.22
0.18
1.6
2.3
2.2
4.7
ug/l
—
7
52
11
92
1.21
0.16
3.4
5.0
—
—
—
0
0
10
83
1.22
0.16
1.1
1.1
—
—
—
0
0
9
107
0.83
0.13
6.0
3.1
—
—
—
0
0
5
46
1.09
0.09
3.2
4.0
2.8
1.1
%
—
5
46
6
58
1.04
0.08
3.3
3.9
1.9
1.8
ug/l
—
6
51
29
274
1.07
0.08
1.9
1.8
—
—
—
0
0
7
66
1.06
0.08
1.1
1.4
—
—
—
0
0
8
75
1.07
0.07
1.3
1.3
—
—
—
0
0
9
83
1.09
0.07
1.6
1.5
—
—
—
0
0
9
83
1.09
0.07
1.6
1.5
—
—
—
0
0
9
85
1.06
0.07
1.8
1.6
—
—
—
0
0
45
437
1.04
0.05
3.3
2.3
—
—
—
0
0
36
348
1.05
0.04
2.9
2.7
—
—
—
0
0
10
91
1.11
0.04
1.0
1.2
—
—
—
0
0
10
109
0.91
0.04
1.9
1.3
—
—
—
0
0
114
1130
1.05
0.03
14.5
11.3
39.9
39.7
%
0.24
81
924
19
183
1.04
0.01
2.1
2.0
—
—
—
0
0
12
122
0.98
0.00
2.1
1.4
—
—
—
0
0
12
122
0.98
0.00
2.3
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
14.2
—
—
—
0
0
0
5
0.00
0.00
0.0
7.4
—
—
—
0
0
5
52
0.96
0.00
1.4
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
10.4
—
0.7
—
0
9
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
7.3
—
14.3
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYTHY_AI_DX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYTHY_AI_DX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: E4_HYTHY_AI_DX – Hypothyroidism, autoimmune, DX-based

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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