No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
743 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
146 |
4. Check minimum number of eventsNone |
146 |
5. Include endpointsNone |
146 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
- Control conditions
- not E4_THYROIDITAUTOIM
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Hypothyroidism, autoimmune, DX-based
based on the number of shared cases.
Similar with more cases:
- Autoimmune thyroiditis
- Thyroiditis
- Thyroiditis, ILD-related definition
- Disorders of thyroid, IBD co-morbidities
- Autoimmune diseases related-to ILD
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1013 | 858 | 154 |
| Only index persons | 972 | 826 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.77 | 27.49 | 15.90 |
| Only index persons | 26.47 | 28.23 | 16.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 128 | 14 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | 39.36 | 39.01 | 42.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
14259.0
191.6
141
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
10016.9
184.3
145
18
H03AA01
ATC
levothyroxine sodium; systemic
242.2
94.4
143
238
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
16.2
67.0
86
119
104
Kela drug reimbursment
Thyroid insufficiency
12.6
44.2
53
63
T86
ICPC
Hypothyroidism/myxoedema
11.6
24.0
27
28
E03.89
ICD-10 Finland
Other specified hypothyroidism
18.3
20.6
32
22
E03
ICD-10 Finland
Other hypothyroidism
6.8
17.9
32
58
A10AB05
ATC
insulin aspart; parenteral
7.6
15.0
23
35
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
10.5
12.9
25
28
XCK10
NOMESCO Finland
Photography of fundus of eye
6.2
12.3
23
43
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
19.0
11.5
17
10
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.0
11.3
40
127
A10AE04
ATC
insulin glargine; parenteral
5.6
11.2
23
47
103
Kela drug reimbursment
Diabetes, insulin-treated
3.9
11.1
40
129
A10AC01
ATC
insulin (human); parenteral
5.5
10.9
23
48
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.7
10.4
21
42
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
11.9
10.1
18
17
A10AE05
ATC
insulin detemir; parenteral
7.7
9.2
21
31
A10AB04
ATC
insulin lispro; parenteral
8.8
8.7
18
23
H04AA01
ATC
glucagon; nasal, parenteral
11.8
8.5
15
14
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
8.1
50
221
H03BB01
ATC
carbimazole; oral
4.8
7.2
17
39
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.2
7.1
15
20
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
7.1
37
148
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
10.1
6.9
13
14
A10AB01
ATC
insulin (human); parenteral
7.8
6.9
15
21
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
8.0
6.6
14
19
T89
ICPC
Diabetes insulin dependent
6.5
6.5
16
27
E03.8
ICD-10 Finland
Other specified hypothyroidism
72.9
6.5
7
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
11.8
6.4
11
10
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
6.3
6
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
9.2
6.2
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
96
10.78
43.58
4.3
3.5
4.42
4.80
pmol/l
1.27
57
82
46
134
4.55
14.96
1.5
1.2
371.45
188.80
iu/ml
1.53
31
50
23
50
5.27
10.42
2.0
1.7
3.47
9.07
iu/l
0.97
11
16
104
707
2.64
6.63
7.0
9.3
3.71
4.00
e9/l
0.69
93
630
81
498
2.41
6.33
6.5
6.3
1.21
1.22
mmol/l
0.72
72
431
51
255
2.54
6.27
1.5
1.3
18.13
21.95
iu/ml
0.23
16
83
64
360
2.38
6.05
1.8
1.3
4.40
1.10
u/ml
0.52
23
101
69
408
2.31
5.75
4.3
4.1
36.58
36.82
g/l
0.13
63
392
117
899
2.52
4.86
5.7
3.6
10.84
9.27
mm/h
0.87
108
827
47
253
2.26
4.73
1.6
1.3
5.13
6.87
u/ml
0.22
18
110
16
51
3.40
4.36
2.4
1.5
0.20
0.23
g/l
1.12
16
51
14
41
3.67
4.30
4.4
2.0
—
—
—
0
0
45
247
2.19
4.27
6.2
3.4
2.68
14.48
mg/mmol
2.45
33
134
74
501
1.97
3.92
2.9
2.4
75.81
74.48
nmol/l
0.16
67
449
8
11
7.62
3.91
1.0
1.4
—
—
—
0
0
58
361
2.01
3.90
3.8
2.8
—
—
—
0
0
9
16
5.92
3.72
2.2
1.9
—
—
—
0
0
68
459
1.90
3.53
6.1
5.7
1.21
1.22
mmol/l
1.03
63
425
57
363
1.94
3.53
2.2
3.0
2.34
2.36
mmol/l
0.82
51
326
59
396
1.82
3.02
6.7
9.3
1.08
1.13
inr
0.21
12
127
11
32
3.63
2.97
1.2
1.3
306.20
318.00
ug/g
—
5
15
88
669
1.79
2.94
4.3
3.9
6.92
6.18
mmol/l
2.38
81
591
33
187
1.99
2.80
1.5
1.6
465.52
41615377.42
pmol/l
0.50
27
161
138
1251
2.88
2.69
14.5
10.4
14.37
18.23
mg/l
1.46
117
929
13
52
2.65
2.43
1.7
1.4
—
—
—
0
0
49
331
1.72
2.36
2.7
3.0
19.48
19.31
ng/l
0.01
29
178
6
13
4.76
2.29
1.2
5.3
—
—
—
0
0
126
1107
2.01
2.23
10.9
9.3
91.93
91.33
ml/min/173m2
0.11
106
882
5
9
5.71
2.23
1.2
1.7
1.93
1.94
mmol/l
—
5
9
80
622
1.63
2.22
3.9
3.2
0.00
0.01
estimate
—
8
133
7
20
3.62
2.08
1.0
1.1
—
—
—
0
0
17
84
2.16
2.05
4.4
7.2
-0.17
1.22
mmol/l
0.65
11
67
28
167
1.84
2.03
2.4
2.4
0.99
0.93
e6/l
0.04
17
95
22
122
1.95
1.97
2.0
2.3
23.27
22.83
%
0.04
15
106
9
33
2.84
1.97
1.2
1.9
381.78
333.52
mg/l
—
9
33
5
11
4.66
1.95
1.0
3.4
—
—
—
0
0
5
11
4.66
1.95
1.0
1.3
—
—
—
0
0
79
629
1.56
1.87
5.3
4.5
0.00
0.00
estimate
—
8
124
6
17
3.63
1.85
2.8
2.6
129.28
86.15
ug/min
—
6
10
79
634
1.54
1.77
3.9
3.3
0.00
0.00
estimate
—
7
122
6
18
3.43
1.76
2.2
2.0
—
—
—
0
0
49
354
1.58
1.76
2.3
2.2
46.48
54.48
u/l
2.07
44
332
23
137
1.81
1.67
2.0
2.1
2.56
2.45
g/l
0.42
18
124
22
132
1.78
1.57
1.6
1.6
—
—
—
0
0
62
482
1.50
1.57
3.9
3.2
—
—
—
0
0
74
598
1.48
1.54
2.4
2.3
—
—
—
0
0
16
87
1.94
1.53
1.4
1.3
472.40
427.70
u/ml
0.04
16
81
24
150
1.72
1.50
2.0
2.2
12.98
14.15
umol/l
0.38
18
135
16
88
1.92
1.48
1.4
1.5
—
—
—
0
0
40
286
1.55
1.48
3.2
2.6
0.02
0.26
e6/l
4.23
29
215
5
16
3.20
1.45
2.0
1.0
—
—
—
0
0
45
332
1.51
1.44
4.1
3.3
0.00
0.00
estimate
—
7
126
13
67
2.03
1.43
1.6
1.3
—
—
—
0
0
11
53
2.16
1.42
1.5
1.5
—
—
—
0
0
7
29
2.48
1.41
2.7
1.1
0.64
0.89
nmol/l
—
7
24
24
153
1.68
1.40
2.7
2.7
3.69
4.55
e6/l
0.24
13
80
10
47
2.21
1.37
3.5
2.8
26.17
24.03
mmol/l
—
10
47
9
42
2.22
1.36
1.4
4.2
166.56
156.14
%
—
9
42
18
107
1.78
1.33
4.1
6.7
106.83
104.36
mmol/l
2.07
18
107
38
275
1.52
1.32
1.7
2.0
0.69
1.18
mg/l
0.70
29
197
11
55
2.08
1.31
2.2
1.4
—
—
—
0
0
5
18
2.84
1.29
1.4
1.2
—
—
—
0
0
15
87
1.81
1.20
1.2
1.5
—
—
—
0
0
5
20
2.55
1.16
2.0
2.6
25.20
23.43
mmol/l
—
5
20
80
680
1.39
1.15
3.6
2.8
61.16
65.95
ug/l
0.32
74
631
38
283
1.46
1.15
1.8
2.0
—
—
—
0
0
39
293
1.45
1.13
2.4
2.2
2.64
2.77
mg/l
0.17
33
241
125
1154
1.58
1.12
4.7
3.8
1.52
1.54
mmol/l
0.21
119
1074
8
148
0.51
1.11
3.1
1.6
—
—
—
0
0
7
32
2.25
1.09
2.3
8.6
23.57
24.30
mmol/l
—
7
32
126
1168
1.57
1.07
5.1
4.1
2.93
2.86
mmol/l
0.44
120
1083
22
148
1.57
1.06
1.4
1.6
978.63
1110.06
nmol/l
0.39
17
107
24
165
1.54
1.05
1.7
2.5
2.41
2.43
mmol/l
0.43
18
150
7
34
2.11
1.04
1.0
1.5
—
—
—
0
0
41
316
1.41
1.03
1.8
1.6
1.32
1.32
mmol/l
0.01
36
278
7
35
2.05
1.01
1.1
2.4
—
—
—
0
0
24
167
1.52
1.00
3.2
3.2
35.59
206.80
ng/l
0.82
13
100
0
29
0.00
0.99
0.0
2.0
—
—
—
0
0
47
378
1.36
0.91
2.5
1.7
—
—
—
0
0
6
29
2.11
0.90
1.0
1.2
—
—
—
0
0
8
43
1.91
0.89
4.8
3.4
47.26
44.93
%
—
8
43
119
1106
1.41
0.84
4.2
3.4
1.20
1.19
mmol/l
0.04
111
1023
6
33
1.85
0.80
1.3
1.2
—
—
—
0
0
6
33
1.85
0.80
1.2
1.4
—
—
—
0
0
5
24
2.12
0.75
1.2
1.1
—
—
—
0
0
14
95
1.52
0.67
1.3
1.7
—
—
—
0
0
12
79
1.57
0.65
1.4
1.3
—
—
—
0
0
47
397
1.27
0.63
2.0
1.7
99.24
100.18
pmol/l
0.04
30
200
94
864
1.25
0.59
2.9
3.0
41.97
35.45
u/l
0.45
89
822
6
35
1.74
0.58
1.8
2.0
—
—
—
0
0
6
36
1.69
0.57
1.7
2.0
—
—
—
0
0
6
99
0.59
0.54
2.7
3.1
—
—
—
0
0
7
46
1.55
0.49
1.4
1.1
—
10.85
—
0
8
12
85
1.45
0.48
1.5
2.8
—
76.03
—
0
31
17
129
1.36
0.48
1.6
1.4
—
—
—
0
0
16
121
1.36
0.46
3.2
2.5
41.80
4492.37
u/l
—
5
48
13
95
1.40
0.45
1.1
1.0
—
—
—
0
0
14
105
1.37
0.43
1.4
1.5
—
—
—
0
0
14
105
1.37
0.43
1.4
1.5
—
—
—
0
0
14
105
1.37
0.43
1.4
1.5
—
—
—
0
0
14
105
1.37
0.43
1.4
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
40
352
1.19
0.36
1.4
1.5
—
—
—
0
0
6
43
1.41
0.35
2.0
1.3
—
—
—
0
0
12
91
1.35
0.35
3.2
5.0
2.42
1.57
mmol/l
1.12
12
69
6
46
1.32
0.33
1.2
1.1
—
—
—
0
0
118
1141
1.18
0.28
4.4
3.7
6.10
5.60
mmol/l
1.99
112
1051
35
314
1.15
0.25
2.5
2.3
—
—
—
0
0
5
40
1.26
0.22
1.4
1.2
—
—
—
0
0
5
41
1.23
0.22
1.2
4.2
3.78
3.46
g/l
—
5
41
5
41
1.23
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
105.83
—
0
12
7
60
1.17
0.18
1.6
2.3
2.17
4.89
ug/l
—
7
54
5
65
0.76
0.17
1.2
1.3
—
—
—
0
0
8
71
1.13
0.16
1.6
1.5
—
—
—
0
0
13
113
1.17
0.13
1.5
1.6
—
—
—
0
0
31
289
1.09
0.12
2.3
2.2
—
—
—
0
0
21
194
1.10
0.09
1.6
1.5
—
—
—
0
0
5
48
1.04
0.09
3.2
3.9
2.82
1.16
%
—
5
48
6
73
0.81
0.08
1.3
1.8
—
—
—
0
0
8
90
0.88
0.07
1.3
1.3
—
—
—
0
0
19
202
0.93
0.05
2.9
1.9
—
—
—
0
0
10
90
1.12
0.05
1.5
1.6
—
—
—
0
0
15
156
0.96
0.00
2.5
1.8
—
—
—
0
0
104
1042
0.99
0.00
4.0
3.8
—
—
—
0
0
13
125
1.04
0.00
8.2
4.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
0.00
0.0
1.0
—
151.25
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
1581.71
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
112.40
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
3.3
4.2
1.89
1.68
ug/l
—
6
59
0
6
0.00
-0.00
0.0
4.0
—
20.70
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
-0.00
1.6
2.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHY_AI_DX and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYTHY_AI_DX.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYTHY_AI_DX – Hypothyroidism, autoimmune, DX-based
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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