≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Autoimmune thyroiditis

DOID EFO Endpoint Browser PheWeb

E4_THYROIDITAUTOIM

autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.3
  • Hospital discharge: ICD-9 — 2452
  • Cause of death: ICD-10 — E06.3
  • Cause of death: ICD-9 — 2452

2 out of 7 registries used, show all original rules.

706

4. Check minimum number of events

None

706

5. Include endpoints

None

706

6. Filter based on genotype QC (FinnGen only)

706

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E06
Name in latin
Thyreoiditis autoimmunis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5469 4605 837
Only index persons 5134 4357 777
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.02
Only index persons 0.14 0.16 0.03
Median age at first event (years)
Whole population 38.53 38.87 36.49
Only index persons 38.30 38.64 36.40

-FinnGen-

Key figures

All Female Male
Number of individuals 706 614 92
Unadjusted period prevalence (%) 0.19 0.21 0.04
Median age at first event (years) 44.37 43.56 49.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
626
Matched controls
6259
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
16384.0
323.0
581
*
H03AA01
ATC
levothyroxine sodium; systemic
351.6
323.0
495
66
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
800.3
270.0
247
5
104
Kela drug reimbursment
Thyroid insufficiency
2964.5
211.9
193
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
937.3
154.2
145
*
H03BB01
ATC
carbimazole; oral
151.9
98.3
102
8
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
93.1
87
*
E03
ICD-10 Finland
Other hypothyroidism
95.5
89.0
97
12
E03.89
ICD-10 Finland
Other specified hypothyroidism
771.5
71.6
69
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
199.7
69.6
71
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
58.2
55
*
T86
ICPC
Hypothyroidism/myxoedema
91.2
52.9
58
7
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
50.7
48
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
82.7
47.8
53
7
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
39.0
37
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
340.0
32.2
32
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.4
27.7
39
17
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
75.7
26.0
29
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
86.7
22.8
25
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
54.1
22.2
26
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
21.4
65
128
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
15.3
19.6
32
22
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
18.8
18
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
68.6
17.8
20
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
17.8
17
*
H02AB06
ATC
prednisolone; systemic
2.1
17.7
301
1903
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
19.1
16.1
24
13
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
14.6
14
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
13.9
174
941
C07AB07
ATC
bisoprolol; oral
2.0
13.4
232
1432
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.6
13.1
45
103
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
17.2
13.1
20
12
A02BC02
ATC
pantoprazole; systemic
1.9
13.0
383
2853
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
12.5
12
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
21.8
12.1
17
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
11.5
247
1624
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
11.5
11
*
C07AA05
ATC
propranolol; systemic
2.1
11.3
142
763
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.8
11.0
47
132
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
44.1
11.0
13
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
61.0
10.7
12
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.6
10.1
25
39
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
9.7
32
71
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
9.6
32
72
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.6
9.5
32
73
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
101.5
9.4
10
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
9.4
9
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
9.4
9
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
9.1
51
175
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
37.2
9.0
11
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.5
8.8
25
47
H04AA01
ATC
glucagon; nasal, parenteral
4.8
8.8
28
60
R00.2
ICD-10 Finland
Palpitations
2.8
8.8
55
206
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.0
8.4
49
175
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
91.2
8.4
9
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
8.3
8
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
8.3
8
*
A10AE05
ATC
insulin detemir; parenteral
3.3
8.2
41
132
B03BA03
ATC
hydroxocobalamin; parenteral
3.9
8.2
32
85
N06AX21
ATC
duloxetine; oral
2.3
8.0
74
342
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.0
107
583
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
7.9
36
109
H02AB09
ATC
hydrocortisone; systemic
6.0
7.7
20
34
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.7
133
796
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.8
7.7
31
85
2504
FHL
Unilateral resection or enucleation
81.0
7.4
8
*
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
7.3
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.1
164
1075
K90.0
ICD-10 Finland
Coeliac disease
3.8
7.0
28
76
A10AA01
ATC
NA
4.2
6.8
24
59
A02BC03
ATC
lansoprazole; oral
1.7
6.7
160
1057
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.1
6.6
74
374
TEA00
NOMESCO Finland
Biopsy of lip
10.2
6.6
12
12
N03AX12
ATC
gabapentin; oral
2.0
6.5
89
490
R03AC02
ATC
salbutamol; inhalant
1.5
6.5
327
2599
E06.0
ICD-10 Finland
Acute thyroiditis
70.5
6.4
7
*
107
Kela drug reimbursment
Pernicious anaemia
8.3
6.4
13
16
T89
ICPC
Diabetes insulin dependent
3.3
6.3
30
95
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
6.3
6
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
6.3
6
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
+∞
6.3
6
*
M79.1
ICD-10 Finland
Myalgia
1.9
6.2
89
497
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
6.2
58
271
N03AX16
ATC
pregabalin; oral
1.7
6.2
126
793
A10AA02
ATC
NA
3.8
6.1
24
65
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.1
110
663

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
263
203
20.05
292.34
4.8
1.5
4.7
4.5
pmol/l
0.66
239
179
138
83
20.42
170.23
2.2
1.2
4.2
1.7
iu/l
2.40
68
15
247
375
9.59
167.23
1.5
1.2
309.1
88.1
iu/ml
11.67
148
124
680
4599
14.00
63.24
11.6
2.6
15.5
14.2
pmol/l
31.67
660
4217
140
458
3.57
35.71
2.5
1.8
401.8
386.8
nmol/l
0.39
128
421
685
5470
9.48
33.32
13.0
3.4
2.1
1.8
mu/l
2.72
666
5079
279
1519
2.38
26.30
1.4
1.3
3.3
1.5
u/ml
0.71
89
388
387
2435
2.30
25.83
7.2
5.8
1.2
1.2
mmol/l
0.26
333
2062
176
811
2.56
23.55
1.6
1.3
541.5
608.4
titre
0.21
54
167
556
4229
2.48
21.86
4.9
3.8
11.4
10.8
mm/h
0.56
523
3930
435
3008
2.16
21.33
4.6
4.1
6.7
6.4
mmol/l
1.74
406
2740
551
4241
2.36
19.96
7.7
6.4
72.9
75.6
u/l
1.22
524
3974
335
2178
2.02
18.44
6.1
5.1
1.2
1.2
mmol/l
0.69
304
1973
73
239
3.29
18.14
1.4
1.2
1.3
2.5
u/ml
0.31
13
20
249
1461
2.09
18.11
4.2
3.2
7.4
7.4
ph
0.24
46
268
455
3328
2.03
17.61
8.8
8.0
3.8
4.0
e9/l
1.35
402
2890
323
2105
1.99
17.35
4.5
4.2
36.4
36.2
g/l
0.33
300
1963
241
1421
2.06
17.12
2.3
2.0
134.3
206.7
u/l
0.84
232
1352
226
1305
2.08
16.96
1.5
1.5
2.0
2.2
g/l
1.34
138
792
390
2754
1.93
16.12
5.2
5.2
9.5
10.4
umol/l
1.42
372
2603
92
375
2.67
15.41
2.0
1.3
—
—
—
0
0
197
1117
2.06
15.30
1.4
1.2
18.5
27.9
iu/ml
1.59
56
343
273
1741
1.93
15.09
2.8
3.0
2.3
2.4
mmol/l
1.99
248
1538
344
2366
1.89
15.06
2.7
2.3
77.3
75.7
nmol/l
0.49
319
2174
666
5873
3.37
13.83
15.1
11.6
139.5
139.6
mmol/l
0.86
654
5700
667
5889
3.40
13.77
15.2
11.6
3.9
3.9
mmol/l
0.02
654
5698
251
1611
1.87
13.23
2.5
2.3
54.1
55.1
u/l
0.22
230
1485
178
1030
1.97
12.77
1.6
1.6
58451155.1
45776686.4
pmol/l
0.08
142
876
399
2968
1.79
12.74
5.8
5.6
0.2
0.2
e9/l
0.37
359
2624
502
4039
1.84
11.92
4.6
4.0
—
—
—
0
0
393
2948
1.75
11.83
5.8
5.3
1.9
1.9
e9/l
0.37
362
2620
664
5940
2.98
11.55
14.5
10.9
17.5
21.2
mg/l
2.57
550
4510
260
1748
1.77
11.40
3.2
3.0
32.7
26.8
ng/l
0.15
153
988
382
2864
1.73
11.33
5.7
5.4
0.0
0.0
e9/l
0.17
338
2478
380
2847
1.72
11.28
5.7
5.4
0.5
0.5
e9/l
1.58
339
2473
32
84
3.94
11.04
1.3
1.7
0.6
0.8
g/l
0.42
23
73
88
410
2.31
10.99
2.6
2.6
11.3
10.5
g/l
0.91
80
377
214
1373
1.80
10.91
3.8
4.0
—
—
—
0
0
131
723
2.00
10.59
3.7
3.0
0.8
0.8
mmol/l
0.44
123
682
174
1064
1.84
10.31
1.4
1.2
2.8
10.1
u/ml
2.79
68
441
311
2258
1.67
9.97
3.3
3.1
—
—
—
0
0
203
1322
1.75
9.65
4.7
3.9
4.5
9.8
mg/mmol
2.79
137
823
220
1476
1.71
9.36
3.5
3.0
7.0
7.4
mmol/l
0.82
198
1270
363
2788
1.62
9.01
6.1
5.4
30.6
29.1
%
1.81
336
2605
360
2761
1.62
8.98
5.9
5.2
54.9
56.8
%
2.25
333
2586
43
156
2.87
8.97
1.6
1.2
20.2
3.0
u/ml
—
6
21
368
2857
1.60
8.58
3.3
2.7
100.4
78.0
ug/l
1.01
341
2673
339
2583
1.60
8.54
6.2
5.5
0.7
0.7
%
0.98
308
2402
351
2701
1.60
8.45
6.3
5.6
8.6
8.1
%
1.57
323
2533
144
879
1.80
8.42
2.3
2.5
2.4
2.4
mmol/l
0.52
124
765
456
3739
1.62
8.37
3.6
3.1
—
—
—
0
0
371
2897
1.59
8.36
3.8
3.3
0.0
0.0
estimate
0.50
65
549
472
3908
1.63
8.27
4.7
4.0
4219.6
2684.9
e6/l
—
10
44
48
193
2.60
8.24
3.4
3.5
25.8
25.1
mmol/l
0.78
48
187
376
2953
1.58
8.21
3.9
3.3
0.0
0.0
estimate
0.80
64
537
372
2926
1.57
7.98
5.0
4.6
0.0
0.0
estimate
0.50
61
556
244
1742
1.61
7.91
2.9
2.6
—
—
—
0
0
676
6266
2.86
7.90
11.7
8.7
24.4
24.1
u/l
0.14
661
6062
70
341
2.17
7.84
2.7
4.0
57.7
79.8
ng/l
3.77
60
306
346
2690
1.56
7.72
6.0
5.4
3.0
2.7
%
0.99
316
2503
66
321
2.16
7.42
1.5
1.8
1.3
1.4
g/l
0.28
58
297
248
1802
1.58
7.36
5.9
7.4
1.2
1.2
inr
0.22
80
561
101
575
1.88
7.34
4.8
5.4
1.0
1.1
mmol/l
0.39
95
539
132
819
1.75
7.23
2.3
2.4
80.3
96.4
ug/g
0.64
99
625
187
1275
1.63
7.20
4.0
3.2
964.1
428.7
mg/l
0.47
119
801
194
1337
1.62
7.15
3.4
3.2
—
—
—
0
0
17
41
4.22
6.58
1.9
1.4
—
—
—
0
0
182
1259
1.60
6.53
3.6
3.5
1.0
1.0
kg/l
0.05
22
174
672
6282
2.45
6.41
14.2
10.1
—
—
—
0
0
19
51
3.80
6.40
1.1
1.2
—
—
nmol/l
—
0
0
254
1905
1.52
6.34
3.1
3.3
69.4
54.0
e6/l
0.29
185
1237
22
66
3.41
6.32
1.7
1.2
—
—
—
0
0
28
98
2.93
6.27
1.6
1.4
—
—
—
0
0
119
747
1.71
6.21
2.3
2.2
14.3
13.9
umol/l
0.24
105
685
19
53
3.66
6.07
1.3
1.2
2.7
2.9
g/l
0.10
13
44
19
53
3.66
6.07
1.3
1.2
6.7
6.8
g/l
0.03
13
45
19
53
3.66
6.07
1.3
1.2
0.3
0.4
g/l
1.74
13
45
569
5074
1.63
6.05
6.3
4.6
40.4
38.2
mmol/mol
4.65
545
4763
156
1060
1.61
5.98
2.3
2.3
7.0
8.2
e6/l
0.39
135
921
209
1525
1.53
5.85
2.8
2.8
44.6
83.1
e6/l
0.70
168
1131
188
1341
1.55
5.83
1.8
1.7
0.9
1.0
mg/l
0.25
135
1000
64
338
1.98
5.80
2.4
2.8
68.4
67.8
g/l
0.28
59
310
19
55
3.52
5.76
1.3
1.2
—
—
—
0
0
91
543
1.78
5.66
1.2
1.2
—
—
—
0
0
239
1809
1.49
5.56
6.4
5.5
—
—
—
0
0
69
381
1.90
5.50
3.3
4.1
2.3
2.0
mmol/l
0.41
58
301
33
136
2.50
5.45
1.5
1.4
311.7
323.8
ug/g
0.12
15
72
192
1394
1.52
5.44
2.9
2.7
0.2
0.4
e6/l
0.85
152
1002
182
1307
1.53
5.43
2.3
2.1
2.4
2.9
mg/l
2.42
154
1123
69
383
1.89
5.42
3.8
3.1
1.2
1.2
mmol/l
0.20
59
330
101
629
1.71
5.41
2.4
2.2
25.0
23.4
%
0.51
77
535
17
48
3.60
5.35
1.2
1.2
—
—
—
0
0
10
18
5.62
5.33
2.3
1.7
—
—
—
0
0
143
978
1.58
5.29
2.4
2.5
533.3
535.1
mosm/kgh2o
0.03
121
824
40
186
2.22
5.07
1.7
1.3
15.7
10.5
u/l
0.89
30
149
208
1557
1.48
5.03
4.4
3.5
0.0
0.0
estimate
0.80
60
545
39
181
2.22
4.97
3.1
2.9
1.3
1.2
%
0.30
39
181
49
251
2.02
4.86
3.1
3.2
—
—
—
0
0
85
523
1.71
4.76
6.9
6.1
104.4
104.3
mmol/l
0.01
85
510
55
297
1.92
4.71
2.2
2.2
—
—
—
0
0
316
2580
1.41
4.70
8.9
8.0
0.0
0.0
e9/l
0.60
262
2096
28
115
2.49
4.68
3.5
4.5
—
—
—
0
0
186
1384
1.47
4.58
2.9
2.7
—
—
—
0
0
7
5
14.12
4.58
1.0
1.0
—
—
—
0
0
17
54
3.20
4.51
1.1
1.2
—
—
—
0
0
42
210
2.06
4.46
1.5
1.2
—
—
—
0
0
105
694
1.60
4.46
2.3
2.1
2.4
2.4
g/l
0.06
93
642
192
1449
1.45
4.37
7.1
6.0
—
—
—
0
0
115
784
1.56
4.28
1.7
1.6
1190.9
1207.6
nmol/l
0.08
96
600
22
84
2.67
4.26
1.1
1.0
—
—
—
0
0
246
1950
1.40
4.23
2.1
1.8
96.7
96.2
pmol/l
0.05
136
1001
42
216
2.00
4.15
2.0
2.0
22.4
20.4
s
0.58
36
188
47
252
1.93
4.13
3.4
3.5
131.6
127.8
g/l
0.66
47
247
171
1278
1.45
4.07
2.4
2.3
2610.9
5725.9
umol/l
0.63
142
1123
695
6719
3.21
4.00
22.8
16.2
270.0
260.9
e9/l
3.69
685
6568
695
6724
3.16
3.89
22.7
16.1
90.2
90.5
fl
0.82
690
6640
695
6725
3.15
3.87
22.7
16.1
30.0
30.1
pg
0.56
690
6640
695
6726
3.14
3.85
22.8
16.1
4.5
4.5
e12/l
0.40
687
6559
20
77
2.64
3.83
1.1
1.7
—
—
—
0
0
695
6728
3.12
3.81
22.9
16.2
6.5
6.6
e9/l
0.79
687
6559
222
1757
1.38
3.78
2.1
2.0
—
—
—
0
0
12
34
3.57
3.78
1.1
1.4
—
—
—
0
0
52
298
1.80
3.74
3.2
2.7
103.1
136.2
ng/l
0.55
46
271
113
790
1.51
3.74
1.6
1.5
—
—
—
0
0
695
6731
3.09
3.74
22.8
16.2
133.8
133.6
g/l
0.28
689
6648
107
740
1.53
3.73
1.3
1.2
—
—
—
0
0
207
1626
1.39
3.68
3.7
2.9
—
—
—
0
0
598
5556
1.50
3.67
4.5
3.8
5.9
5.7
mmol/l
1.27
560
5119
22
91
2.46
3.67
1.1
1.0
—
—
—
0
0
37
191
1.99
3.65
8.3
7.5
—
—
—
0
0
31
152
2.09
3.51
6.0
5.2
—
—
—
0
0
65
405
1.67
3.50
1.5
1.3
32.4
24.9
iu/l
0.84
53
347
176
1355
1.40
3.50
3.5
3.3
—
—
—
0
0
14
47
3.02
3.43
1.4
1.1
—
—
—
0
0
76
496
1.60
3.42
1.4
1.4
—
—
—
0
0
46
262
1.81
3.40
5.8
6.7
—
—
—
0
0
187
1469
1.37
3.28
1.8
1.6
1.3
1.3
mmol/l
0.03
151
1274
154
1174
1.40
3.23
4.5
3.7
—
—
—
0
0
584
5438
1.43
3.19
4.1
3.4
1.2
1.2
mmol/l
0.19
546
5078
42
239
1.81
3.13
1.8
2.3
0.1
0.2
e6/l
0.36
42
230
20
87
2.34
3.03
3.9
4.3
—
—
—
0
0
558
5171
1.38
3.00
16.5
13.3
13.4
13.5
%
1.00
546
5066
613
5775
1.47
2.99
5.2
4.2
2.9
2.9
mmol/l
0.83
579
5400
65
423
1.59
2.98
1.1
1.2
—
—
—
0
0
121
897
1.42
2.97
4.0
3.0
110.9
344.2
ng/l
1.17
70
579
84
583
1.50
2.89
2.7
2.5
5.1
6.0
umol/l
0.51
62
493
61
396
1.59
2.83
3.3
3.1
—
—
—
0
0
67
448
1.55
2.75
3.0
3.8
0.9
0.9
%
0.01
17
122
602
5672
1.42
2.74
4.6
3.7
1.5
1.6
mmol/l
1.61
567
5314
604
5695
1.42
2.73
4.7
3.8
4.8
4.8
mmol/l
0.00
576
5356
52
328
1.63
2.72
6.2
7.7
—
—
—
0
0
20
92
2.21
2.69
2.2
2.8
82.9
109.2
ug/min
0.15
14
59
10
32
3.16
2.65
1.7
1.7
10.3
10.8
umol/l
—
10
32
321
2788
1.28
2.64
4.0
3.8
—
—
—
0
0
60
399
1.55
2.53
3.0
4.0
0.3
0.1
%
0.30
13
89
42
256
1.68
2.51
2.2
2.2
—
—
—
0
0
102
757
1.41
2.49
2.6
2.6
4.3
3.4
e6/l
0.32
57
359
69
477
1.49
2.45
7.3
7.6
1.6
1.4
mmol/l
0.21
55
376
82
587
1.45
2.44
1.2
1.3
—
—
—
0
0
23
118
1.98
2.38
3.6
3.7
18.3
52.7
mg/l
0.73
17
93
23
118
1.98
2.38
3.6
3.7
18.1
42.0
mg/l
4.27
17
95
166
1340
1.31
2.37
2.2
2.0
—
—
—
0
0
60
408
1.51
2.31
3.1
3.7
0.3
0.6
%
0.84
11
82
108
823
1.37
2.26
1.4
1.4
—
—
—
0
0
37
225
1.68
2.25
7.2
10.1
—
—
—
0
0
18
86
2.12
2.24
2.1
2.5
—
—
—
0
0
10
36
2.80
2.21
2.0
2.4
0.3
0.2
e9/l
—
10
31
10
36
2.80
2.21
1.1
1.2
—
—
—
0
0
8
24
3.36
2.18
1.0
1.0
—
—
—
0
0
6
14
4.31
2.15
1.3
1.0
—
—
—
0
0
61
424
1.48
2.13
3.1
3.9
0.0
0.1
%
2.84
15
107
8
25
3.22
2.10
1.0
1.0
—
—
—
0
0
48
318
1.55
2.09
1.6
1.5
293.1
293.8
mu/l
0.00
41
276
23
125
1.87
2.04
1.6
1.4
—
—
—
0
0
25
140
1.81
2.03
1.5
1.4
0.4
0.4
nmol/l
0.08
17
120
24
133
1.83
2.02
1.0
1.1
2.1
5.4
u/ml
1.14
11
73
23
127
1.84
1.96
1.0
1.1
0.2
1.6
u/ml
—
10
55
10
39
2.59
1.92
2.0
2.3
513.3
514.7
e6/l
—
10
32
61
434
1.44
1.91
5.7
3.6
—
—
—
0
0
6
17
3.55
1.84
1.2
1.1
—
—
—
0
0
82
624
1.36
1.76
1.4
1.3
—
—
—
0
0
26
155
1.70
1.75
1.1
1.1
4.3
1.7
u/ml
0.30
11
59
20
110
1.84
1.74
1.2
1.2
10.4
3.4
u/ml
—
7
38
5
13
3.87
1.71
1.4
1.0
4.1
6.2
mg/g
—
5
13
60
436
1.41
1.70
1.4
1.4
—
—
—
0
0
43
293
1.50
1.69
1.5
1.3
254.2
244.5
miu/ml
0.06
27
150
38
252
1.54
1.69
1.4
1.3
—
—
—
0
0
19
104
1.85
1.68
1.5
1.2
—
—
—
0
0
52
372
1.43
1.61
2.9
2.6
—
—
—
0
0
7
26
2.71
1.58
2.9
1.2
—
—
—
0
0
67
503
1.37
1.58
5.4
3.4
—
—
—
0
0
66
495
1.37
1.57
12.5
16.8
1.0
1.2
inr
3.17
13
73
13
64
2.05
1.55
1.0
1.1
—
—
—
0
0
10
44
2.29
1.53
1.1
1.0
—
—
—
0
0
5
15
3.35
1.52
1.2
1.5
—
—
—
0
0
134
1119
1.24
1.45
1.6
1.5
21.4
21.8
nmol/l
0.13
121
972
11
52
2.13
1.45
2.5
2.5
—
—
—
0
0
158
1346
1.22
1.42
1.7
1.7
—
—
—
0
0
27
173
1.58
1.42
1.0
1.2
—
—
—
0
0
10
46
2.19
1.40
3.1
2.0
33.2
32.2
pg
—
10
46
11
53
2.09
1.39
2.5
2.4
4.0
4.0
mmol/l
0.10
11
53
11
53
2.09
1.39
2.5
2.4
106.5
106.8
mmol/l
0.11
11
53
6
23
2.62
1.37
1.8
1.5
26.8
31.5
umol/l
—
6
23
23
143
1.63
1.36
2.0
1.6
—
—
—
0
0
10
47
2.14
1.34
1.3
1.1
—
—
—
0
0
9
42
2.16
1.34
2.7
3.5
—
—
—
0
0
86
689
1.28
1.32
2.2
1.9
—
—
—
0
0
0
41
0.00
1.31
0.0
1.2
—
—
—
0
0
16
91
1.78
1.30
1.2
1.2
—
—
—
0
0
19
114
1.69
1.29
2.7
2.1
—
—
—
0
0
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
13
70
1.87
1.24
2.1
2.1
—
—
—
0
0
47
349
1.37
1.23
1.3
1.2
—
—
—
0
0
26
172
1.53
1.22
3.1
3.3
0.2
0.3
g/l
0.69
11
70
19
117
1.64
1.19
1.3
1.3
—
—
—
0
0
20
125
1.62
1.18
1.1
1.1
—
—
—
0
0
20
125
1.62
1.18
1.1
1.1
—
—
—
0
0
20
125
1.62
1.18
2.3
1.1
—
—
—
0
0
16
94
1.72
1.18
2.8
2.4
1.3
2.3
mmol/l
—
10
64
0
33
0.00
1.16
0.0
1.5
—
—
—
0
0
8
39
2.06
1.15
1.3
1.1
—
—
—
0
0
58
450
1.31
1.15
2.9
2.2
5447.1
4858.3
u/l
0.04
21
197
33
457
0.71
1.14
1.4
1.4
—
—
—
0
0
39
285
1.39
1.13
1.1
1.1
—
—
—
0
0
241
2181
1.16
1.08
3.1
2.4
—
—
—
0
0
14
82
1.72
1.05
4.1
2.7
—
—
—
0
0
17
106
1.62
1.03
2.2
2.1
130.7
130.5
g/l
—
10
76
15
91
1.66
1.01
2.1
1.7
—
—
—
0
0
18
115
1.58
1.00
1.3
1.2
—
—
—
0
0
48
371
1.32
1.00
1.4
1.4
—
—
—
0
0
57
453
1.28
0.97
3.6
4.0
44.9
18.0
ug/l
0.38
43
368
0
30
0.00
0.97
0.0
2.5
—
9.1
—
0
23
35
260
1.36
0.95
3.4
4.2
7.4
7.4
ph
—
5
36
6
27
2.23
0.93
1.3
1.1
151.8
207.4
iu/ml
—
6
27
9
52
1.74
0.92
1.0
1.1
—
—
—
0
0
42
324
1.32
0.90
3.5
2.8
58.5
72.5
e9/l
2.81
34
230
8
44
1.83
0.86
1.1
2.1
—
—
—
0
0
31
231
1.36
0.84
1.3
1.3
—
—
—
0
0
10
57
1.77
0.84
1.5
1.5
—
—
—
0
0
6
32
1.88
0.82
3.5
3.0
—
—
—
0
0
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
17
116
1.48
0.75
1.4
1.3
291.3
208.9
u/ml
0.52
12
66
5
24
2.09
0.74
1.0
1.5
162.0
156.3
nmol/l
—
5
24
72
609
1.20
0.74
2.2
1.5
—
—
—
0
0
83
712
1.19
0.74
1.2
1.2
—
—
—
0
0
17
117
1.46
0.72
2.9
3.6
13.3
25.5
mg/l
—
8
72
5
28
1.79
0.66
4.0
3.3
—
—
—
0
0
29
224
1.31
0.65
2.3
2.0
—
—
—
0
0
40
323
1.25
0.65
1.8
1.5
—
—
—
0
0
61
716
0.84
0.64
1.3
1.3
—
—
—
0
0
40
324
1.25
0.64
1.8
1.5
—
—
—
0
0
13
87
1.50
0.63
2.4
2.1
16.1
16.3
%
—
5
45
174
1595
1.12
0.63
2.1
2.0
—
—
—
0
0
40
325
1.24
0.62
1.8
1.5
—
—
—
0
0
14
96
1.47
0.62
1.6
1.9
13.2
13.1
%
0.14
14
96
32
254
1.27
0.60
1.8
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
67.8
—
0
14
0
20
0.00
0.60
0.0
6.1
—
—
—
0
0
0
21
0.00
0.60
0.0
3.9
—
89.4
—
0
15
580
5670
1.13
0.59
15.7
11.8
39.4
39.5
%
0.11
424
4429
18
132
1.37
0.57
1.9
2.0
—
—
—
0
0
6
36
1.67
0.56
1.3
1.0
—
—
—
0
0
12
82
1.47
0.54
1.2
1.6
—
—
—
0
0
39
322
1.22
0.54
1.8
1.5
—
—
—
0
0
9
60
1.51
0.54
1.7
2.8
—
—
—
0
0
9
61
1.48
0.54
2.0
1.5
—
—
—
0
0
13
91
1.44
0.53
1.5
1.8
—
—
—
0
0
56
488
1.16
0.46
5.7
4.7
1.7
2.3
ug/l
0.97
48
432
7
51
1.38
0.44
1.0
1.1
—
—
—
0
0
8
57
1.41
0.42
1.0
1.1
—
—
—
0
0
10
70
1.43
0.42
1.7
1.3
—
—
—
0
0
10
70
1.43
0.42
1.7
1.3
—
—
—
0
0
10
70
1.43
0.42
1.7
1.3
—
—
—
0
0
10
70
1.43
0.42
1.7
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
15.1
—
0
15
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
—
—
0
0
0
17
0.00
0.40
0.0
2.2
—
2764.7
—
0
9
14
106
1.33
0.39
1.9
1.8
7255.6
11135.4
e6/l
—
8
75
11
80
1.38
0.38
1.1
1.1
—
—
—
0
0
25
206
1.22
0.38
2.7
4.2
24.3
24.2
mmol/l
0.07
20
187
5
37
1.35
0.37
3.0
2.3
—
—
—
0
0
9
70
1.29
0.36
3.0
2.3
—
—
—
0
0
35
301
1.17
0.35
1.8
1.6
—
—
—
0
0
6
43
1.40
0.35
1.0
1.0
—
0.5
—
0
10
6
44
1.37
0.34
2.3
1.4
—
—
—
0
0
30
256
1.18
0.33
1.9
1.5
—
—
—
0
0
6
46
1.31
0.33
1.2
1.3
—
—
—
0
0
23
193
1.20
0.31
3.7
4.5
—
—
—
0
0
7
53
1.32
0.31
3.6
2.9
0.7
0.9
nmol/l
—
7
42
7
54
1.30
0.30
2.0
2.2
—
—
—
0
0
14
111
1.27
0.30
1.2
1.5
—
—
—
0
0
17
139
1.23
0.29
1.8
1.8
—
—
—
0
0
15
121
1.24
0.28
1.1
1.1
—
—
—
0
0
251
2430
1.05
0.24
2.3
1.9
—
—
—
0
0
23
265
0.86
0.24
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.4
1.4
—
65.0
—
0
5
5
40
1.25
0.22
1.0
1.1
—
0.1
—
0
12
5
41
1.22
0.22
1.8
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
33.7
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
7.8
—
25.8
—
0
12
0
13
0.00
0.21
0.0
1.1
—
0.6
—
0
7
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
52
1.16
0.19
1.2
1.3
—
—
—
0
0
86
816
1.06
0.18
1.8
1.9
—
—
—
0
0
22
195
1.13
0.17
1.1
1.2
—
—
—
0
0
8
68
1.18
0.16
3.5
2.1
2.6
8.1
u/ml
—
8
61
6
80
0.75
0.15
2.3
2.7
—
—
—
0
0
28
306
0.91
0.14
1.6
1.5
—
—
—
0
0
17
151
1.13
0.13
2.6
2.3
9.0
6.2
umol/l
0.46
12
112
28
258
1.09
0.12
1.7
1.8
—
—
—
0
0
28
300
0.93
0.10
1.5
1.4
—
—
—
0
0
42
399
1.06
0.09
2.5
2.3
3.8
4.1
e9/l
0.25
36
334
21
194
1.09
0.09
1.1
1.2
—
—
—
0
0
28
298
0.94
0.08
1.5
1.4
—
—
—
0
0
6
72
0.83
0.07
1.2
1.4
—
—
—
0
0
188
1909
0.98
0.07
1.7
1.6
—
—
—
0
0
8
93
0.86
0.06
1.3
1.5
—
—
—
0
0
28
294
0.95
0.06
4.3
2.9
0.6
0.8
ug/l
0.81
22
192
10
110
0.91
0.05
3.2
3.9
54.0
57.6
%
—
10
110
56
545
1.03
0.05
1.6
1.3
—
—
—
0
0
109
1080
1.01
0.02
1.5
1.7
—
—
—
0
0
10
107
0.93
0.02
3.0
3.8
4.4
4.3
e9/l
—
10
107
15
144
1.04
0.00
2.2
3.1
—
—
—
0
0
5
50
1.00
0.00
2.6
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
1.6
—
0
8
0
7
0.00
0.00
0.0
5.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
166.8
—
0
6
0
9
0.00
0.00
0.0
10.6
—
—
—
0
0
0
5
0.00
0.00
0.0
9.2
—
0.3
—
0
5
7
71
0.99
0.00
1.3
2.6
48.7
62.3
%
—
7
71
0
9
0.00
0.00
0.0
10.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
9
95
0.95
0.00
1.4
3.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITAUTOIM and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITAUTOIM 1.029 [0.88, 1.2] 0.713
Birth year 0.996 [0.99, 1.0] 0.367

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 3629 females with E4_THYROIDITAUTOIM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITAUTOIM.

N-year risk Females Males
1 0.083% No data
5 0.497% No data
10 1.444% No data
15 2.964% No data
20 5.351% No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data