autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
743 |
4. Check minimum number of eventsNone |
743 |
5. Include endpointsNone |
743 |
6. Filter based on genotype QC (FinnGen only) |
724 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis autoimmunis
Similar endpoints
↥List of similar endpoints to
Autoimmune thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5469 | 4605 | 837 |
| Only index persons | 5134 | 4357 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.02 |
| Only index persons | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 38.53 | 38.87 | 36.49 |
| Only index persons | 38.30 | 38.64 | 36.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 724 | 626 | 98 |
| Unadjusted period prevalence (%) | 0.20 | 0.22 | 0.04 |
| Median age at first event (years) | 44.75 | 43.96 | 49.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 743
- Matched controls
- 7430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
259.7
307.7
582
102
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
241.1
307.7
310
22
E06.3
ICD-10 Finland
Autoimmune thyroiditis
4503599627370496.0
307.7
695
*
104
Kela drug reimbursment
Thyroid insufficiency
1437.8
225.1
208
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
1156.2
189.3
177
*
H03BB01
ATC
carbimazole; oral
344.4
142.8
140
5
E03
ICD-10 Finland
Other hypothyroidism
262.0
130.5
130
6
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
1192.0
108.2
103
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
365.6
96.3
95
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
201.8
87.3
89
5
T86
ICPC
Hypothyroidism/myxoedema
163.9
84.0
87
6
BAA60
NOMESCO Finland
Total thyroidectomy
709.1
67.1
65
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
27.4
63.8
44
17
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
168.8
59.9
62
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
54.9
52
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
19.8
54.8
43
23
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
53.8
51
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
72.1
36.3
41
6
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
35.1
72
143
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
57.1
32.6
38
7
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.4
29.5
60
118
E06.9
ICD-10 Finland
Thyroiditis, unspecified
107.7
28.9
31
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.4
24.8
42
69
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
24.1
23
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
23.0
22
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
33.5
22.6
29
9
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
107.9
19.7
21
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.7
19.3
31
48
A10AE05
ATC
insulin detemir; parenteral
4.1
18.4
52
134
H02AB06
ATC
prednisolone; systemic
2.0
18.3
361
2401
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
18.6
17.9
27
15
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
17.8
17
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
17.4
59
173
A10AB05
ATC
insulin aspart; parenteral
3.4
17.2
65
204
A10AB04
ATC
insulin lispro; parenteral
4.7
17.2
40
88
H04AA01
ATC
glucagon; nasal, parenteral
5.5
17.0
33
62
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
16.7
16
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
16.1
216
1243
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.9
16.0
29
51
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.3
15.8
42
103
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
87.0
15.6
17
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
22.6
15.6
22
10
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
57.9
14.8
17
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
14.6
14
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
14.6
14
*
C07AB07
ATC
bisoprolol; oral
1.9
14.3
291
1912
A10AB01
ATC
insulin (human); parenteral
4.3
14.1
37
90
T85
ICPC
Hyperthyroidism/thyrotoxicosis
76.6
13.6
15
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
13.2
307
2088
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
12.5
13.2
23
19
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.7
13.0
24
43
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
12.5
12
*
A10AA02, ,
ATC
4.7
12.5
29
64
A10AA01, ,
ATC
4.8
12.4
28
60
A02BC02
ATC
pantoprazole; systemic
1.8
12.4
484
3800
C07AA05
ATC
propranolol; systemic
1.9
12.1
183
1084
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
11.7
146
808
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
5.1
11.5
24
48
A10AC01
ATC
insulin (human); parenteral
2.8
11.5
61
233
H02AB09
ATC
hydrocortisone; systemic
5.0
11.3
24
49
T89
ICPC
Diabetes insulin dependent
3.4
11.1
40
122
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
5.5
10.9
21
39
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
111.5
10.4
11
*
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
+∞
10.4
10
*
A10AE04
ATC
insulin glargine; parenteral
2.6
10.3
62
253
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
10.3
221
1449
BA1AE, ,
SPAT
9.7
9.8
19
20
R00.2
ICD-10 Finland
Palpitations
2.4
9.8
73
329
R06.0
ICD-10 Finland
Dyspnoea
1.8
9.6
182
1148
K90.0
ICD-10 Finland
Coeliac disease
3.5
9.4
32
94
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
9.4
9
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
9.4
9
*
B03BA03
ATC
hydroxocobalamin; parenteral
3.1
9.1
37
122
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.0
9.0
103
550
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.7
8.9
15
12
177
Kela drug reimbursment
Insulin glargine 300 U / ml
4.8
8.9
20
43
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
8.8
8.8
18
21
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
16.5
8.6
13
8
M25.5
ICD-10 Finland
Pain in joint
1.6
8.5
252
1781
106
Kela drug reimbursment
Hypoparathyroidism
+∞
8.3
8
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
8.3
219
1502
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
9.6
8.3
16
17
A02BC03
ATC
lansoprazole; oral
1.7
8.2
196
1311
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
8.2
160
1014
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
8.1
54
231
J01FF01
ATC
clindamycin; systemic
1.7
8.1
189
1256
N03AX12
ATC
[U] gabapentin; oral
1.8
7.8
120
706
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
7.8
215
1488
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.9
7.7
22
57
H3600, E103,
ICD-10 Finland
7.5
7.7
17
23
SXA20
NOMESCO Finland
Local application of medicine to mouth
2.2
7.5
61
285
SPAT1097
SPAT
Recording of ECG
2.0
7.5
87
466
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.5
143
896
R53
ICD-10 Finland
Malaise and fatigue
1.7
7.5
172
1134
2504
FHL
Unilateral resection or enucleation
80.9
7.4
8
*
R07.0
ICD-10 Finland
Pain in throat
2.2
7.4
65
314
J01AA02
ATC
doxycycline; systemic
1.6
7.3
540
4642
UJF32
NOMESCO Finland
Coloscopy
1.7
7.3
158
1025
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
7.3
7
*
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
7.3
7
*
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
15.9
7.2
11
7
ZXH06, ,
SPAT
2.7
7.2
39
151
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.0
119
721
R06AE07
ATC
cetirizine; oral
1.5
6.8
340
2669
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
4.0
6.7
19
49
K29.4
ICD-10 Finland
Chronic atrophic gastritis
5.6
6.6
18
33
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.6
236
1724
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
6.6
63
315
TEA00
NOMESCO Finland
Biopsy of lip
8.8
6.6
13
15
R03AC02
ATC
salbutamol; inhalant
1.5
6.5
412
3384
CKC12
NOMESCO Finland
Photocoagulation of retina
3.0
6.5
28
96
H3602, E103,
ICD-10 Finland
70.4
6.4
7
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
70.4
6.4
7
*
N06AX21
ATC
duloxetine; oral
1.8
6.3
92
532
XKD00
NOMESCO Finland
Uroflowmetry
2.2
6.3
52
245
M54.5
ICD-10 Finland
Low back pain
1.5
6.3
263
1985
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
6.3
6
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
6.3
6
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
6.3
6
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
6.3
6
*
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
6.3
57
280
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.7
6.3
128
817
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.8
6.3
31
115
H36.00
ICD-10 Finland
Diabetic background retinopathy
7.1
6.2
14
20
WZC30
NOMESCO Finland
Teaching
1.8
6.2
97
573
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.2
83
467
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
6.2
39
163
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.2
166
1133
EP1AE, ,
SPAT
3.5
6.2
21
62
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
6.1
49
228
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
6.1
39
164
J01
ICD-10 Finland
Acute sinusitis
2.2
6.1
50
235
E83.51
ICD-10 Finland
Hypocalcemia
12.6
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
281
201
21.87
307.65
4.8
1.3
4.70
4.52
pmol/l
0.88
257
176
155
72
26.94
214.93
2.3
1.2
4.01
1.69
iu/l
2.34
73
13
272
353
11.58
211.39
1.6
1.2
304.25
82.60
iu/ml
12.63
160
116
714
4810
13.41
66.87
11.5
2.5
15.49
14.20
pmol/l
32.24
694
4404
146
477
3.56
37.26
2.5
1.8
409.03
383.65
nmol/l
0.82
134
437
719
5739
8.83
34.68
12.9
3.3
2.13
1.81
mu/l
3.69
700
5327
406
2538
2.32
27.66
6.9
5.8
1.22
1.22
mmol/l
0.07
348
2171
292
1587
2.38
27.59
1.4
1.3
3.18
1.49
u/ml
0.68
93
404
580
4434
2.40
21.83
4.9
3.8
11.26
10.77
mm/h
0.39
546
4120
452
3172
2.09
20.48
4.5
4.1
6.77
6.42
mmol/l
2.14
421
2894
572
4441
2.25
19.23
7.6
6.4
72.78
75.41
u/l
1.20
544
4175
349
2272
2.01
18.99
6.0
5.1
1.22
1.22
mmol/l
0.19
320
2086
239
1360
2.12
18.78
1.5
1.5
2.03
2.23
g/l
1.45
144
833
478
3499
2.03
18.36
8.7
8.1
3.76
3.97
e9/l
1.30
420
3051
74
253
3.14
17.08
1.4
1.2
1.43
2.47
u/ml
0.26
12
20
336
2218
1.94
17.01
4.4
4.2
36.48
36.23
g/l
0.38
313
2073
248
1495
1.99
16.22
2.2
2.0
137.47
203.98
u/l
0.79
239
1420
205
1164
2.05
15.79
1.4
1.3
17.84
30.25
iu/ml
2.20
60
374
284
1814
1.92
15.52
2.8
3.1
2.34
2.36
mmol/l
1.93
260
1618
358
2469
1.87
15.37
2.6
2.3
76.95
75.92
nmol/l
0.29
332
2269
403
2890
1.86
15.23
5.2
5.2
9.60
10.33
umol/l
1.20
384
2742
699
6161
3.27
14.36
14.9
11.6
139.48
139.62
mmol/l
0.91
688
5980
700
6175
3.31
14.36
14.9
11.6
3.92
3.92
mmol/l
0.08
688
5975
260
1685
1.84
13.10
2.5
2.3
54.23
58.35
u/l
0.80
238
1558
53
178
3.13
12.58
1.5
1.2
7.40
43.16
u/ml
—
5
15
699
6240
3.03
12.46
14.2
11.0
18.00
21.14
mg/l
2.00
576
4743
273
1826
1.78
12.20
3.1
3.0
32.03
26.79
ng/l
0.14
159
1031
181
1073
1.91
11.90
1.7
1.6
57639339.84
43825567.21
pmol/l
0.09
144
915
183
1110
1.86
11.13
1.4
1.2
2.72
9.97
u/ml
2.89
71
457
91
429
2.28
11.02
2.6
2.6
11.39
10.51
g/l
1.19
82
391
43
139
3.22
10.88
1.4
1.2
52.71
38.16
u/ml
—
9
18
214
1377
1.78
10.66
4.5
3.7
5.27
8.75
mg/mmol
1.50
145
862
234
1547
1.75
10.60
3.5
3.0
6.97
7.47
mmol/l
0.97
215
1347
135
767
1.93
9.94
3.7
2.9
0.83
0.82
mmol/l
0.85
128
730
51
194
2.75
9.72
3.3
3.4
25.89
25.07
mmol/l
1.03
51
188
51
202
2.64
9.00
2.3
2.1
—
—
—
0
0
151
918
1.81
8.93
2.3
2.5
2.43
2.44
mmol/l
0.41
130
801
496
4109
1.62
8.61
4.6
4.0
4219.60
2736.05
e6/l
—
10
43
297
2181
1.60
8.60
8.5
10.3
1.20
1.16
inr
0.41
97
676
73
348
2.22
8.59
2.6
4.0
57.97
79.44
ng/l
3.79
63
310
378
2940
1.58
8.56
6.1
5.5
30.42
29.09
%
1.63
350
2772
395
3107
1.58
8.49
3.8
3.3
0.00
0.01
estimate
0.80
65
576
390
3061
1.58
8.45
3.8
3.3
0.00
0.00
estimate
0.80
70
620
383
2996
1.57
8.40
3.3
2.7
99.29
77.88
ug/l
1.00
356
2802
374
2910
1.57
8.39
5.9
5.3
55.02
56.75
%
2.11
345
2738
391
3074
1.57
8.38
4.9
4.6
0.00
0.00
estimate
0.50
62
594
43
162
2.76
8.37
1.6
1.2
20.22
3.07
u/ml
—
6
22
43
164
2.72
8.18
1.6
1.2
6.79
5.59
u/ml
—
7
36
34
114
3.08
8.14
1.5
1.2
—
—
—
0
0
710
6586
2.76
8.04
11.5
8.7
24.59
24.11
u/l
0.28
695
6372
178
1176
1.68
7.75
2.9
2.7
670.27
834.98
ng/l
0.64
147
963
313
2373
1.55
7.66
4.0
3.3
—
—
—
0
0
83
446
1.97
7.13
2.8
2.3
13.89
26.19
au/ml
—
7
37
103
597
1.84
7.04
4.7
5.3
1.04
1.06
mmol/l
0.45
97
559
76
399
2.01
6.97
1.6
1.3
41.48
31.56
au/ml
—
6
25
192
1326
1.60
6.92
3.6
3.4
1.02
1.02
kg/l
0.05
23
179
490
4159
1.52
6.69
3.2
2.7
40.76
39.00
u/l
0.19
457
3930
20
55
3.71
6.51
1.3
1.1
—
—
—
0
0
597
5317
1.63
6.39
6.2
4.6
40.50
38.21
mmol/mol
5.23
572
4988
74
399
1.95
6.30
3.2
4.0
2.23
1.94
mmol/l
0.35
66
328
194
1377
1.55
6.13
2.3
2.1
2.39
2.86
mg/l
3.15
164
1184
196
1395
1.55
6.11
1.8
1.7
0.88
1.00
mg/l
0.36
143
1039
629
5696
1.68
6.07
11.7
9.7
88.17
87.70
ml/min/173m2
0.21
533
4567
42
184
2.36
6.06
3.0
2.8
0.66
0.67
%
0.01
42
184
35
142
2.54
5.94
1.4
1.4
331.88
326.19
ug/g
0.05
17
75
42
188
2.31
5.78
3.0
2.8
1.35
1.19
%
0.29
42
188
24
81
3.03
5.73
1.3
1.2
—
—
—
0
0
121
779
1.66
5.70
2.3
2.1
14.25
13.98
umol/l
0.17
107
720
259
1984
1.47
5.60
3.5
2.9
31.94
28.71
u/l
0.56
245
1889
213
1576
1.49
5.46
1.9
1.6
—
—
—
0
0
65
353
1.92
5.43
2.4
2.8
68.43
67.83
g/l
0.32
60
324
91
550
1.75
5.40
6.5
5.9
104.26
104.38
mmol/l
0.07
91
550
216
1607
1.49
5.37
2.8
2.8
43.93
80.08
e6/l
0.67
171
1188
51
256
2.07
5.32
3.2
3.5
131.06
127.65
g/l
0.56
51
251
71
403
1.84
5.19
3.7
3.1
1.23
1.23
mmol/l
0.10
61
349
159
1117
1.54
5.18
2.3
2.3
6.91
7.34
e6/l
0.14
138
989
199
1468
1.49
5.13
2.9
2.7
0.24
0.35
e6/l
0.67
155
1064
103
657
1.66
5.02
2.4
2.2
24.74
23.47
%
0.40
79
561
27
105
2.63
5.02
3.0
2.3
—
—
—
0
0
16
47
3.46
4.77
1.3
1.0
0.90
1.11
u/l
—
9
19
215
1636
1.44
4.67
4.4
3.5
0.00
0.00
estimate
0.80
61
584
126
861
1.56
4.62
2.6
2.4
0.74
0.97
e6/l
0.64
75
443
40
194
2.12
4.58
1.6
1.3
15.69
11.15
u/l
0.74
30
154
15
45
3.38
4.34
1.1
1.2
—
—
—
0
0
731
7067
3.13
4.14
22.5
16.2
270.06
260.95
e9/l
3.94
720
6908
731
7067
3.13
4.14
22.6
16.1
39.86
39.75
%
0.22
689
6688
107
722
1.56
4.14
2.3
2.1
2.42
2.41
g/l
0.07
95
666
179
1343
1.44
4.14
2.4
2.2
2489.68
5400.21
umol/l
0.62
150
1195
69
419
1.71
4.05
1.5
1.3
32.23
25.23
iu/l
0.80
55
358
254
2033
1.38
4.03
2.1
1.8
97.04
96.08
pmol/l
0.11
138
1048
118
821
1.52
3.98
1.7
1.6
1177.56
1211.16
nmol/l
0.19
99
626
731
7076
3.05
3.95
22.5
16.1
4.48
4.46
e12/l
0.53
722
6900
112
774
1.53
3.89
1.8
1.8
—
—
—
0
0
731
7081
3.00
3.85
22.5
16.2
133.97
133.62
g/l
0.36
725
6994
197
1533
1.39
3.66
1.8
1.6
1.35
1.33
mmol/l
0.13
160
1326
22
94
2.38
3.44
2.0
2.7
100.08
84.01
ug/min
0.09
16
58
614
5715
1.43
3.35
4.1
3.4
1.22
1.22
mmol/l
0.07
575
5336
53
319
1.71
3.25
3.1
2.6
103.13
134.76
ng/l
0.52
46
289
645
6070
1.47
3.21
5.2
4.1
2.91
2.86
mmol/l
0.80
610
5686
30
152
2.01
3.14
1.6
1.5
2.72
7.38
e6/l
1.35
25
113
89
616
1.51
3.09
2.7
2.5
5.11
5.92
umol/l
0.47
65
522
340
2927
1.30
3.07
2.5
2.4
—
—
—
0
0
634
5959
1.44
3.06
4.6
3.7
1.51
1.55
mmol/l
1.67
598
5593
623
5838
1.42
3.05
4.4
3.8
5.84
5.71
mmol/l
1.19
584
5379
636
5983
1.44
3.03
4.7
3.8
4.81
4.81
mmol/l
0.06
607
5635
601
5601
1.38
3.01
16.0
13.2
14.33
14.47
%
0.29
591
5505
14
51
2.78
3.00
1.4
1.2
—
—
—
0
0
14
51
2.78
3.00
1.4
1.2
—
—
—
0
0
18
76
2.40
2.91
1.3
1.1
—
—
—
0
0
14
52
2.72
2.90
1.4
1.2
—
—
—
0
0
14
52
2.72
2.90
1.4
1.2
—
—
—
0
0
14
52
2.72
2.90
1.4
1.2
—
—
—
0
0
177
1410
1.34
2.76
2.1
2.0
—
—
—
0
0
48
295
1.67
2.76
1.4
1.4
—
—
—
0
0
42
250
1.72
2.71
1.8
2.4
0.10
0.16
e6/l
0.39
42
239
53
336
1.62
2.71
2.1
1.7
—
—
—
0
0
8
19
4.24
2.68
1.3
1.0
—
—
—
0
0
125
949
1.38
2.65
3.9
3.0
109.32
340.73
ng/l
1.22
71
608
77
541
1.47
2.51
1.8
1.7
—
—
—
0
0
34
195
1.78
2.51
2.4
2.2
98.00
93.93
%
0.86
34
189
76
533
1.47
2.50
1.7
1.7
—
—
—
0
0
65
444
1.51
2.43
1.3
1.2
190.68
227.49
u/ml
0.14
60
410
106
799
1.38
2.36
2.5
2.5
4.33
3.76
e6/l
0.17
57
382
71
502
1.46
2.26
7.1
7.6
1.66
1.30
mmol/l
0.29
55
402
29
165
1.79
2.22
2.9
2.4
3.36
3.69
g/l
0.62
29
157
13
54
2.43
2.20
1.8
1.3
—
—
—
0
0
22
115
1.94
2.17
1.0
1.2
—
—
—
0
0
10
36
2.80
2.14
1.7
1.6
10.26
10.90
umol/l
—
10
36
32
190
1.72
2.13
1.3
1.2
—
—
—
0
0
50
334
1.53
2.10
1.6
1.4
291.88
291.27
mu/l
0.00
42
293
16
75
2.16
2.09
1.3
1.1
—
—
—
0
0
5
10
5.03
2.07
1.0
1.1
—
—
—
0
0
23
125
1.87
2.04
3.6
3.7
18.11
41.20
mg/l
4.30
17
100
23
125
1.87
2.04
3.6
3.7
18.29
51.10
mg/l
0.74
17
98
8
26
3.10
2.02
1.0
1.0
—
—
—
0
0
32
195
1.67
1.96
1.8
1.4
—
—
—
0
0
22
120
1.86
1.94
1.2
1.1
8.78
3.27
u/ml
—
9
41
5
11
4.57
1.94
1.2
1.1
—
—
—
0
0
55
382
1.47
1.94
5.9
5.9
1.23
1.25
mmol/l
0.06
55
372
9
33
2.75
1.93
2.1
1.9
—
—
—
0
0
21
113
1.88
1.93
1.2
1.3
—
—
—
0
0
25
143
1.77
1.91
1.5
1.4
0.42
0.39
nmol/l
0.07
17
123
58
409
1.45
1.90
1.1
1.0
—
—
—
0
0
24
136
1.79
1.89
1.0
1.1
3.00
1.04
u/ml
0.56
11
59
13
59
2.22
1.85
1.4
1.4
—
—
—
0
0
8
30
2.68
1.72
3.9
3.4
725.88
514.30
u/ml
—
8
30
10
40
2.52
1.67
2.0
2.3
0.25
0.17
e9/l
—
10
35
11
49
2.26
1.64
1.1
1.5
—
—
—
0
0
60
439
1.40
1.64
3.7
2.4
72.61
74.08
ml/min/173m2
0.11
23
166
37
246
1.53
1.63
2.1
1.7
—
—
—
0
0
20
113
1.79
1.62
1.2
1.0
1.63
1.82
u/ml
—
6
57
21
121
1.76
1.60
1.2
1.1
8.91
4.74
u/ml
0.26
11
39
10
43
2.34
1.59
2.0
2.2
513.30
512.06
e6/l
—
10
36
70
529
1.36
1.58
2.8
2.6
—
—
—
0
0
11
50
2.22
1.57
1.0
1.0
—
—
—
0
0
15
79
1.92
1.50
2.1
2.1
—
—
—
0
0
71
543
1.34
1.49
1.8
2.1
28.89
33.45
u/l
0.86
61
453
49
667
0.72
1.47
1.8
1.6
—
—
—
0
0
138
1160
1.23
1.40
1.6
1.5
21.51
21.66
nmol/l
0.04
125
1002
11
53
2.09
1.39
1.5
1.4
—
—
—
0
0
11
53
2.09
1.39
2.5
2.5
4.00
3.98
mmol/l
0.08
11
53
11
53
2.09
1.39
2.5
2.5
106.55
106.72
mmol/l
0.06
11
53
0
38
0.00
1.34
0.0
1.0
—
—
—
0
0
16
90
1.79
1.34
1.0
1.1
—
—
—
0
0
6
24
2.51
1.30
1.8
1.7
26.82
30.79
umol/l
—
6
24
26
169
1.56
1.30
1.1
1.1
3.63
3.16
u/ml
0.05
13
88
16
91
1.77
1.30
1.4
1.3
—
—
—
0
0
506
4788
1.18
1.29
3.7
3.5
—
—
—
0
0
8
34
2.37
1.29
1.5
1.9
—
83.20
%
—
0
5
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
5
18
2.79
1.28
1.0
1.2
—
—
—
0
0
48
355
1.38
1.27
1.5
1.7
—
—
—
0
0
43
313
1.40
1.25
1.5
1.3
254.19
240.34
miu/ml
0.09
27
163
6
25
2.41
1.24
1.2
1.6
—
—
—
0
0
5
19
2.64
1.21
1.0
1.3
—
—
—
0
0
18
109
1.67
1.19
2.2
2.1
130.70
130.99
g/l
—
10
78
6
26
2.32
1.19
1.0
1.3
—
—
—
0
0
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
35
253
1.40
1.08
3.2
4.2
1.22
1.51
mmol/l
0.20
28
185
18
113
1.61
1.06
1.4
1.1
—
—
—
0
0
17
106
1.62
1.03
1.1
1.1
—
—
—
0
0
20
131
1.54
1.00
1.5
1.3
—
—
—
0
0
21
307
0.67
0.99
1.7
1.7
—
—
—
0
0
5
23
2.18
0.98
1.6
1.4
—
—
—
0
0
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
60
483
1.26
0.93
2.8
2.2
5881.33
6220.12
u/l
0.02
22
205
6
28
2.15
0.91
1.3
1.1
151.85
202.51
iu/ml
—
6
28
6
29
2.08
0.89
1.2
1.2
—
—
—
0
0
13
79
1.66
0.88
1.2
1.1
—
—
—
0
0
8
43
1.87
0.87
1.3
1.4
—
—
—
0
0
6
31
1.94
0.84
1.0
1.1
—
—
—
0
0
8
45
1.79
0.84
1.8
1.3
—
—
—
0
0
8
45
1.79
0.84
1.8
1.3
—
—
—
0
0
8
45
1.79
0.84
1.8
1.3
—
—
—
0
0
19
130
1.47
0.81
1.3
1.3
—
—
—
0
0
18
122
1.49
0.80
1.3
1.3
295.29
214.85
u/ml
0.56
13
69
9
54
1.67
0.74
1.3
1.3
—
—
—
0
0
9
55
1.64
0.73
1.3
1.3
—
—
—
0
0
10
60
1.68
0.72
1.2
1.4
—
—
—
0
0
26
194
1.35
0.72
1.9
1.9
—
—
—
0
0
28
212
1.33
0.71
1.4
1.3
—
—
—
0
0
10
61
1.65
0.68
1.2
1.4
—
—
—
0
0
10
61
1.65
0.68
1.5
1.4
—
—
—
0
0
10
61
1.65
0.68
1.2
1.4
—
—
—
0
0
14
94
1.50
0.67
2.3
2.1
16.06
16.50
%
—
5
44
5
28
1.79
0.66
1.0
1.1
—
54.00
—
0
5
5
28
1.79
0.66
1.6
1.4
—
—
—
0
0
15
103
1.47
0.65
1.1
1.1
113.80
120.31
%
0.30
15
97
10
62
1.62
0.65
1.2
1.4
—
—
—
0
0
10
62
1.62
0.65
1.2
1.4
—
—
—
0
0
10
62
1.62
0.65
1.2
1.4
—
—
—
0
0
57
479
1.21
0.64
3.6
4.0
44.86
18.39
ug/l
0.37
43
389
5
30
1.67
0.61
1.0
1.1
—
—
—
0
0
8
50
1.61
0.61
1.3
1.4
—
—
—
0
0
24
184
1.31
0.58
1.9
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
35
1.72
0.57
1.2
1.2
—
—
—
0
0
15
107
1.41
0.55
1.0
1.3
—
—
—
0
0
15
107
1.41
0.55
1.0
1.3
—
—
—
0
0
6
38
1.58
0.54
1.5
1.3
0.98
1.31
nmol/l
—
6
33
60
517
1.17
0.54
5.5
4.7
1.67
2.28
ug/l
1.04
52
459
14
100
1.41
0.52
1.6
2.0
13.21
13.14
%
0.11
14
100
17
128
1.34
0.48
2.9
3.5
13.25
27.32
mg/l
—
8
77
12
85
1.42
0.47
1.5
1.4
—
—
—
0
0
48
415
1.17
0.43
4.9
4.2
19.54
20.86
%
0.28
25
200
8
56
1.43
0.42
4.5
3.9
—
—
—
0
0
12
87
1.39
0.42
1.7
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
4.5
—
—
—
0
0
22
178
1.24
0.39
2.0
1.8
—
—
—
0
0
20
160
1.26
0.39
2.4
2.3
8.42
6.06
umol/l
0.41
13
120
11
80
1.38
0.38
2.2
1.2
—
—
—
0
0
11
80
1.38
0.38
1.1
1.1
88.91
94.04
%
0.25
11
75
15
188
0.79
0.33
1.8
1.5
—
—
—
0
0
12
92
1.31
0.32
1.5
1.3
—
—
—
0
0
58
641
0.90
0.31
4.3
3.7
33.37
32.55
%
0.23
46
445
14
112
1.25
0.28
1.9
1.8
7255.63
10811.91
e6/l
—
8
79
13
103
1.27
0.28
1.5
1.3
—
—
—
0
0
13
103
1.27
0.28
1.5
1.3
—
—
—
0
0
5
72
0.69
0.26
1.2
1.1
—
—
—
0
0
9
73
1.24
0.25
1.3
1.3
—
—
—
0
0
10
78
1.29
0.24
1.7
1.3
—
—
—
0
0
10
78
1.29
0.24
1.7
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.5
—
—
—
0
0
5
39
1.28
0.23
4.6
2.7
—
—
—
0
0
5
40
1.25
0.22
1.8
1.1
—
—
—
0
0
25
284
0.88
0.22
1.6
1.9
—
—
—
0
0
22
252
0.87
0.22
1.7
1.7
—
—
—
0
0
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.4
1.3
83.20
72.05
umol/l
—
5
43
52
481
1.09
0.20
1.3
1.4
—
—
—
0
0
6
50
1.20
0.19
1.2
1.1
—
—
—
0
0
67
712
0.94
0.18
1.4
1.5
—
—
—
0
0
42
387
1.09
0.18
1.3
1.4
—
—
—
0
0
7
62
1.13
0.17
1.6
1.3
—
—
—
0
0
42
388
1.09
0.17
1.3
1.4
—
—
—
0
0
42
388
1.09
0.17
1.3
1.4
—
—
—
0
0
5
67
0.74
0.17
2.0
1.2
—
—
—
0
0
42
389
1.08
0.16
1.3
1.4
—
—
—
0
0
68
643
1.06
0.16
1.8
1.7
—
—
—
0
0
8
72
1.11
0.16
3.5
2.2
2.65
9.46
u/ml
—
8
72
10
119
0.84
0.15
3.2
3.7
54.00
57.83
%
—
10
119
9
79
1.14
0.15
1.7
1.3
—
—
—
0
0
37
342
1.09
0.15
1.4
1.4
—
—
—
0
0
15
132
1.14
0.13
1.5
1.4
—
—
—
0
0
77
737
1.05
0.13
1.5
1.6
1.32
1.35
%
0.22
69
660
119
1152
1.04
0.12
2.0
2.1
—
—
—
0
0
162
1661
0.97
0.12
1.5
1.5
—
—
—
0
0
10
116
0.86
0.12
3.0
3.6
4.41
4.22
e9/l
—
10
116
12
136
0.88
0.11
1.6
1.5
—
—
—
0
0
15
134
1.12
0.11
1.5
1.4
—
—
—
0
0
24
259
0.92
0.10
1.4
1.5
—
—
—
0
0
40
420
0.95
0.08
1.4
1.4
—
—
—
0
0
8
91
0.88
0.07
1.5
1.5
—
—
—
0
0
29
303
0.96
0.05
4.1
2.9
0.64
0.79
ug/l
0.80
22
196
16
171
0.93
0.05
1.2
1.1
—
—
—
0
0
33
342
0.96
0.04
1.5
1.5
—
—
—
0
0
43
418
1.03
0.04
1.3
1.5
—
—
—
0
0
21
200
1.05
0.03
1.1
1.2
—
—
—
0
0
21
200
1.05
0.03
1.1
1.2
—
—
—
0
0
36
349
1.03
0.03
1.4
1.6
—
—
—
0
0
12
112
1.07
0.03
1.1
1.7
—
—
—
0
0
30
309
0.97
0.02
1.7
1.8
3.28
4.63
mg/l
0.30
20
220
14
134
1.05
0.00
1.1
1.2
—
—
—
0
0
82
825
0.99
0.00
2.0
1.9
—
—
—
0
0
61
607
1.01
0.00
7.6
5.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
14.94
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
79
0.88
0.00
1.1
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
15.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
1.14
—
0
7
6
65
0.92
-0.00
1.2
3.5
34.28
70.10
u/ml
—
6
65
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
12
120
1.00
-0.00
1.2
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
5.83
—
0
6
6
61
0.98
-0.00
3.8
1.2
—
—
—
0
0
5
54
0.93
-0.00
1.4
1.4
—
—
—
0
0
127
1270
1.00
-0.00
2.2
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITAUTOIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITAUTOIM | 1.029 [0.88, 1.2] | 0.713 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 3629 females with E4_THYROIDITAUTOIM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITAUTOIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.497% | No data |
| 10 | 1.444% | No data |
| 15 | 2.964% | No data |
| 20 | 5.351% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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