No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
154 |
4. Check minimum number of eventsNone |
154 |
5. Include endpointsNone |
154 |
6. Filter based on genotype QC (FinnGen only) |
146 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis acuta
Similar endpoints
↥List of similar endpoints to
Acute thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1138 | 842 | 289 |
| Only index persons | 1081 | 812 | 269 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.43 | 45.51 | 49.44 |
| Only index persons | 45.78 | 44.95 | 48.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 146 | 112 | 34 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 47.58 | 46.31 | 51.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 154
- Matched controls
- 1540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
197.3
144
*
H03AA01
ATC
levothyroxine sodium; systemic
55.5
115.8
72
24
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
37.0
34
*
H03BB01
ATC
carbimazole; oral
169.7
27.6
28
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.5
27.1
29
28
104
Kela drug reimbursment
Thyroid insufficiency
162.4
26.5
27
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
50.4
24.6
29
7
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
21.3
20
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
19.2
18
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
15.9
15
*
BAA60
NOMESCO Finland
Total thyroidectomy
165.0
14.7
15
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
13.7
13
*
H02AB07
ATC
prednisone; oral
4.4
13.3
40
113
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
55.0
13.1
15
*
T86
ICPC
Hypothyroidism/myxoedema
+∞
11.6
11
*
H02AB06
ATC
prednisolone; systemic
3.3
11.6
97
526
C07AA05
ATC
propranolol; systemic
3.4
11.2
53
204
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
106.3
9.5
10
*
2450A
ICD-9 Finland
Thyroiditis, Acute thyroiditis
+∞
9.5
9
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
95.0
8.5
9
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
8.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
8.1
81
455
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
47.4
7.8
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
7.2
72
400
E03
ICD-10 Finland
Other hypothyroidism
42.0
6.8
8
*
J01FA06
ATC
roxithromycin; oral
2.4
6.6
77
453
XQ800
NOMESCO Finland
Prick test
3.9
6.3
19
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
59
6.33
16.39
1.3
1.2
139.36
97.07
iu/ml
0.18
11
20
130
934
3.51
8.00
7.7
2.5
15.51
14.36
pmol/l
2.67
124
841
49
270
2.20
4.60
2.9
2.1
2.85
2.87
mg/l
0.02
43
235
139
1161
3.03
4.32
8.7
3.2
1.67
1.83
mu/l
1.17
131
1057
34
172
2.25
3.87
2.6
1.7
13.18
14.26
umol/l
0.38
29
161
24
106
2.50
3.68
2.1
2.1
405.29
363.02
nmol/l
0.30
24
94
75
521
1.86
3.49
18.8
12.1
1.33
1.16
inr
0.47
23
157
9
18
5.24
3.42
1.3
1.3
—
—
—
0
0
94
704
1.86
3.41
4.5
4.0
6.81
6.39
mmol/l
0.96
89
649
66
444
1.85
3.37
2.1
1.8
108.85
93.33
pmol/l
1.34
34
214
49
302
1.91
3.27
2.7
2.2
7454.89
7180.91
umol/l
0.01
44
273
79
575
1.77
3.02
6.1
5.2
1.23
1.22
mmol/l
0.52
66
495
116
947
1.91
3.01
5.6
3.9
13.88
10.36
mm/h
2.01
109
862
118
978
1.88
2.80
8.6
6.7
74.43
75.80
u/l
0.12
113
912
28
152
2.03
2.65
3.1
1.6
21.63
24.26
%
0.42
20
132
70
512
1.67
2.50
5.7
4.6
1.22
1.22
mmol/l
0.22
65
477
38
235
1.82
2.45
1.3
1.3
2.55
11.74
u/ml
2.22
11
99
56
388
1.70
2.44
2.3
3.1
2.33
2.36
mmol/l
0.78
47
352
6
12
5.15
2.42
1.3
1.1
—
—
—
0
0
39
248
1.77
2.29
1.2
1.3
10.64
31.81
iu/ml
3.16
11
89
14
66
2.23
1.88
1.4
1.5
—
—
—
0
0
52
375
1.58
1.87
2.2
2.4
51.68
54.47
u/l
0.39
47
351
33
212
1.71
1.85
3.6
3.2
150.64
104.42
ng/l
0.15
22
153
140
1283
2.00
1.71
4.7
4.1
4.78
4.79
mmol/l
0.03
132
1192
60
456
1.52
1.68
3.1
3.6
46.29
25.02
ng/l
0.31
34
294
38
260
1.61
1.68
1.9
1.6
—
—
—
0
0
44
314
1.56
1.63
4.0
3.4
1.64
8.59
mg/mmol
2.81
32
188
82
668
1.49
1.63
5.5
5.5
10.26
10.27
umol/l
0.00
77
633
139
1276
1.92
1.61
4.6
4.0
1.47
1.56
mmol/l
1.91
132
1180
7
26
2.77
1.60
3.0
2.2
—
—
—
0
0
137
1255
1.83
1.55
4.8
4.0
5.93
5.81
mmol/l
0.63
129
1159
134
1226
1.72
1.44
13.9
11.0
84.60
84.93
ml/min/173m2
0.07
118
992
46
341
1.50
1.42
2.1
1.6
1.53
1.31
mmol/l
0.63
39
286
9
41
2.27
1.39
1.3
1.7
0.25
0.22
g/l
—
9
41
77
634
1.43
1.37
3.4
3.5
0.00
0.00
estimate
-0.00
11
137
9
42
2.21
1.36
2.2
2.1
—
—
—
0
0
140
1301
1.84
1.36
5.3
4.5
2.91
2.82
mmol/l
0.57
131
1200
22
138
1.69
1.35
1.7
1.9
—
—
—
0
0
21
131
1.70
1.32
1.7
1.9
—
—
—
0
0
54
420
1.44
1.30
2.4
2.8
—
—
—
0
0
5
19
2.68
1.22
1.0
1.2
—
—
—
0
0
5
19
2.68
1.22
1.0
1.2
—
—
—
0
0
38
281
1.47
1.18
1.4
1.3
0.63
1.86
u/ml
—
9
83
145
1378
1.89
1.16
13.3
9.2
25.64
24.89
u/l
0.28
138
1329
139
1300
1.71
1.16
16.2
12.2
18.07
23.08
mg/l
1.42
122
1002
133
1232
1.58
1.14
4.0
3.6
1.34
1.21
mmol/l
1.01
126
1138
8
41
2.00
1.10
2.5
1.5
—
—
—
0
0
5
21
2.43
1.10
2.8
1.2
—
—
—
0
0
5
21
2.43
1.10
1.2
1.4
—
—
—
0
0
9
45
2.06
1.07
1.3
1.6
1.28
1.15
g/l
—
9
45
27
190
1.51
1.06
1.7
1.9
—
—
—
0
0
7
36
1.99
0.98
1.3
1.2
—
—
—
0
0
127
1177
1.45
0.96
6.7
4.9
39.34
38.76
mmol/mol
0.29
120
1106
75
644
1.32
0.93
3.5
3.5
0.00
0.00
estimate
—
10
124
6
29
2.11
0.90
1.0
1.8
4.98
3.84
g/l
—
6
29
6
29
2.11
0.90
1.0
1.3
—
—
—
0
0
8
42
1.95
0.90
1.1
1.0
—
—
—
0
0
8
42
1.95
0.90
1.1
1.0
—
—
—
0
0
74
637
1.31
0.89
4.9
4.9
0.00
0.00
estimate
—
10
129
143
1363
1.69
0.88
17.8
14.0
71.76
71.01
umol/l
0.21
143
1363
83
728
1.30
0.86
10.8
9.6
3.91
4.01
e9/l
0.21
77
640
6
31
1.97
0.85
1.0
1.3
—
—
—
0
0
5
24
2.12
0.75
3.6
3.8
62.40
62.21
%
—
5
24
5
24
2.12
0.75
1.4
1.2
—
—
—
0
0
7
38
1.88
0.74
1.1
1.1
—
4.23
—
0
6
58
493
1.28
0.74
3.3
3.5
—
—
—
0
0
26
197
1.38
0.72
1.7
1.7
1271.50
1324.70
nmol/l
0.12
20
151
5
27
1.88
0.69
1.8
1.6
—
—
—
0
0
35
281
1.32
0.68
1.4
1.4
—
—
—
0
0
5
28
1.81
0.66
2.2
1.5
—
—
—
0
0
24
182
1.38
0.66
2.0
2.5
0.94
3.02
e6/l
1.60
14
85
7
44
1.62
0.66
1.4
1.2
—
2.52
—
0
5
5
29
1.75
0.64
1.4
2.4
3.64
4.20
umol/l
—
5
22
5
29
1.75
0.64
1.0
1.8
—
—
—
0
0
5
30
1.69
0.62
1.6
1.2
—
—
—
0
0
11
72
1.57
0.61
1.1
1.0
—
—
—
0
0
8
54
1.51
0.58
1.4
1.4
—
—
—
0
0
37
307
1.27
0.57
3.3
3.0
674.11
1126.58
ng/l
0.78
32
257
12
82
1.50
0.56
2.8
2.5
66.82
68.51
g/l
0.58
12
76
11
75
1.50
0.52
1.3
1.4
31.99
27.43
iu/l
0.17
11
69
35
295
1.24
0.47
1.7
1.6
0.73
1.06
mg/l
0.98
27
241
24
193
1.29
0.47
1.9
2.4
0.49
0.81
e6/l
0.88
14
94
21
170
1.27
0.40
1.9
2.1
—
—
—
0
0
17
134
1.30
0.39
3.7
3.0
—
—
—
0
0
9
67
1.36
0.39
6.4
4.6
24.86
24.93
mmol/l
—
9
67
28
237
1.22
0.37
1.8
1.7
400.74
455.26
pmol/l
0.84
23
212
6
45
1.35
0.34
1.5
2.4
—
—
—
0
0
6
46
1.32
0.33
1.3
1.5
—
—
—
0
0
6
46
1.32
0.33
1.3
1.5
—
—
—
0
0
6
46
1.32
0.33
1.3
1.5
—
—
—
0
0
7
54
1.31
0.31
1.9
2.9
0.93
1.42
%
—
7
54
63
590
1.11
0.23
2.4
2.3
—
—
—
0
0
147
1447
1.35
0.23
24.2
18.2
39.92
39.80
%
0.11
135
1365
5
42
1.20
0.21
1.2
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
37
339
1.12
0.20
2.5
2.7
0.18
0.46
e6/l
0.87
26
245
6
52
1.16
0.19
7.7
7.9
24.25
24.48
mmol/l
—
6
52
16
138
1.18
0.18
5.3
6.0
104.31
104.28
mmol/l
0.01
16
138
7
60
1.17
0.18
1.4
1.3
—
—
—
0
0
8
69
1.17
0.17
1.1
1.2
—
—
—
0
0
17
151
1.14
0.14
1.9
2.0
—
—
—
0
0
36
340
1.08
0.10
3.5
3.4
0.00
0.00
estimate
—
9
128
30
281
1.08
0.10
2.2
2.0
—
—
—
0
0
5
43
1.17
0.10
1.2
1.2
—
—
—
0
0
6
53
1.14
0.09
1.5
1.6
—
—
—
0
0
20
185
1.09
0.08
3.4
3.9
16.53
22.34
%
—
10
83
5
62
0.80
0.08
1.0
1.5
—
—
—
0
0
6
74
0.80
0.08
4.0
1.8
—
—
—
0
0
9
86
1.05
0.07
1.6
1.6
—
—
—
0
0
14
131
1.08
0.03
1.8
1.8
—
—
—
0
0
88
890
0.97
0.02
3.2
3.4
—
—
—
0
0
10
94
1.07
0.01
2.9
1.9
—
—
—
0
0
13
131
0.99
0.00
3.5
2.8
0.62
0.73
ug/l
—
8
84
14
141
0.99
0.00
8.1
7.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
10.16
—
0
6
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
61
0.98
-0.00
1.0
2.3
4.48
2.84
mg/l
—
6
43
0
5
0.00
-0.00
0.0
2.8
—
156.60
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
21.27
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.7
0.56
1.78
ug/l
—
5
46
13
130
1.00
-0.00
6.6
7.1
12.28
12.16
kpa
0.04
13
125
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
13
130
1.00
-0.00
6.6
7.2
5.17
5.17
kpa
0.01
13
125
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
-0.00
7.5
7.9
24.86
25.38
mmol/l
—
8
74
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITACU | 1.181 [0.92, 1.52] | 0.199 |
| Birth year | 0.999 [0.99, 1.01] | 0.739 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | No data |
| 5 | 0.776% | No data |
| 10 | 1.927% | No data |
| 15 | 3.803% | No data |
| 20 | 6.664% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITACU – Acute thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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