Acute thyroiditis

E4_THYROIDITACU

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E06.0 Hospital discharge: ICD-9 — 2450 Cause of death: ICD-10 — E06.0 Cause of death: ICD-9 — 2450 2 out of 7 registries used, show all original rules.	151
4. Check minimum number of events None	151
5. Include endpoints None	151
6. Filter based on genotype QC (FinnGen only)	151

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E06
Name in latin: Thyreoiditis acuta

NAME	E4_THYROIDITACU
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E060
HD_ICD_9	2450
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E060
COD_ICD_9	2450
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute thyroiditis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1138	842	289
Only index persons	1081	812	269
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.03	0.01
Median age at first event (years)
Whole population	46.43	45.51	49.44
Only index persons	45.78	44.95	48.29

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	151	116	35
Unadjusted period prevalence (%)	0.03	0.04	0.02
Median age at first event (years)	46.66	45.10	51.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
135: Matched controls
1350

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E06.0

ICD-10 Finland

Acute thyroiditis

+∞

174.6

127

H03AA01

ATC

levothyroxine sodium; systemic

76.6

59.0

E06.1

ICD-10 Finland

Subacute thyroiditis

+∞

33.8

104

Kela drug reimbursment

Thyroid insufficiency

304.0

25.6

H03BB01

ATC

carbimazole; oral

289.2

24.5

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

45.7

19.3

E05.0

ICD-10 Finland

Thyrotoxicosis with diffuse goitre

+∞

19.2

E06.9

ICD-10 Finland

Thyroiditis, unspecified

+∞

15.9

EP1AE

NOMESCO Finland

Neck ultrasound examination

13.7

15.1

BAA60

NOMESCO Finland

Total thyroidectomy

+∞

14.9

E05.9

ICD-10 Finland

Thyrotoxicosis, unspecified

142.7

12.7

E04.2

ICD-10 Finland

Nontoxic multinodular goitre

71.3

11.8

H02AB06

ATC

prednisolone; systemic

3.2

9.8

436

E03.89

ICD-10 Finland

Other specified hypothyroidism

+∞

9.5

E89.01

ICD-10 Finland

Postsurgical hypothyroidism

+∞

9.5

H02AB07

ATC

prednisone; oral

4.2

8.6

E03.80

ICD-10 Finland

Hypothyroidism caused by autoimmune thyroiditis

95.8

8.5

E06.3

ICD-10 Finland

Autoimmune thyroiditis

+∞

7.4

2450A

ICD-9 Finland

Thyroiditis, Acute thyroiditis

+∞

7.4

T86

ICPC

Hypothyroidism/myxoedema

42.2

6.8

J01FA06

ATC

roxithromycin; oral

2.6

6.5

380

C07AA05

ATC

propranolol; systemic

3.0

6.2

165

R03AC02

ATC

salbutamol; inhalant

2.5

6.2

536

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

5.04

12.11

1.3

1.2

148.3

126.1

iu/ml

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

127

919

3.40

7.55

7.8

2.6

15.5

14.4

pmol/l

2.65

121

828

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

267

2.17

4.40

2.9

2.0

2.9

2.8

mg/l

0.01

233

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

136

1140

2.94

4.10

8.7

3.3

1.6

1.8

mu/l

1.54

128

1038

(3036481) Cortisol [Moles/volume] in Serum or Plasma

102

2.61

3.99

2.1

2.0

405.3

361.5

nmol/l

0.31

(3022948) Iron [Moles/volume] in Serum or Plasma

171

2.19

3.55

2.5

1.7

13.3

14.4

umol/l

0.38

158

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

5.24

3.43

1.3

—

(3032080) INR in Blood by Coagulation assay

444

1.86

3.40

9.3

7.5

1.3

1.2

inr

0.44

137

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

438

1.85

3.31

2.1

1.8

108.9

92.6

pmol/l

1.44

209

(3037522) Nuclear Ab [Titer] in Serum

161

2.16

3.30

1.4

822.2

515.0

titre

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

562

1.80

3.15

6.1

5.2

1.2

mmol/l

0.55

480

(3013826) Glucose [Moles/volume] in Serum or Plasma

699

1.81

3.09

4.5

4.0

6.8

6.4

mmol/l

0.98

644

(3037467) Urinalysis macro (dipstick) panel - Urine

106

848

1.84

2.92

4.6

4.2

—

(3018418) pH of Serum or Plasma

348

1.81

2.86

4.6

2.9

7.4

0.03

(42870588) Differential panel, method unspecified - Blood

383

1.78

2.85

7.6

4.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

113

929

1.86

2.77

5.6

3.9

13.9

10.4

mm/h

1.92

106

845

(3007853) Bacteria identified in Skin by Aerobe culture

128

2.14

2.75

1.9

1.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

115

953

1.87

2.72

8.7

6.7

74.6

76.1

u/l

0.13

110

888

(3001604) Monocytes [#/volume] in Blood

608

1.72

2.71

7.3

5.2

0.5

e9/l

0.12

535

(3006315) Basophils [#/volume] in Blood

609

1.71

2.68

7.3

5.2

0.0

e9/l

0.04

536

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

500

1.70

2.59

5.8

4.6

1.2

mmol/l

0.15

462

(3002030) Lymphocytes/100 leukocytes in Blood

585

1.69

2.57

8.2

5.1

28.2

28.3

0.03

554

(3019198) Lymphocytes [#/volume] in Blood

619

1.67

2.45

7.4

5.3

1.9

e9/l

0.11

557

(3009508) Creatinine [Moles/volume] in Urine

319

1.74

2.44

5.0

2.7

8.0

7.3

mmol/l

0.35

260

(3018010) Neutrophils/100 leukocytes in Blood

573

1.66

2.41

8.3

5.0

57.3

57.2

0.05

547

(3006504) Eosinophils/100 leukocytes in Blood

574

1.65

2.39

8.2

5.0

2.6

2.7

0.06

540

(3015377) Calcium [Moles/volume] in Serum or Plasma

382

1.69

2.38

2.3

3.2

2.3

2.4

mmol/l

0.77

341

(3013115) Eosinophils [#/volume] in Blood

632

1.65

2.37

7.4

5.6

0.2

e9/l

0.54

569

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

152

1.95

2.31

3.1

1.6

21.8

24.1

0.34

132

(3023420) DNA double strand Ab [Units/volume] in Serum

4.76

2.29

1.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

4.76

2.29

1.3

1.1

—

(3025941) Bacteria identified in Stool by Culture

2.38

2.26

1.2

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

226

1.78

2.21

1.3

2.5

12.0

u/ml

2.24

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.81

2.18

1.4

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

238

1.73

2.08

1.2

1.3

10.9

31.0

iu/ml

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.35

2.08

1.4

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

162

1.81

1.91

3.0

1.8

74.0

110.7

ug/g

0.58

122

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

367

1.59

1.86

2.2

2.3

52.1

54.7

u/l

0.35

343

(3000494) Fungus identified in Specimen by Culture

140

1.85

1.6

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

137

1247

2.06

1.84

4.6

4.0

1.5

1.6

mmol/l

2.08

129

1152

(3020682) Albumin/Creatinine [Ratio] in Urine

306

1.62

1.84

4.0

3.6

1.6

9.8

mg/mmol

2.91

182

(3013512) EKG study

333

1.60

1.82

3.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.54

1.79

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

3.94

1.73

1.0

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

137

1254

2.00

1.70

4.7

4.1

4.8

mmol/l

0.06

128

1164

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

656

1.51

1.69

5.5

10.3

umol/l

0.01

621

(3017143) Hepatitis C virus Ab [Presence] in Serum

137

1.80

1.67

1.6

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.88

1.67

3.0

2.0

—

(3005570) Glucose [Moles/volume] in Urine

3.65

1.63

1.4

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

147

1.75

1.59

1.8

1.9

—

(3008898) HLA-B27 [Presence]

2.13

1.59

1.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

134

1227

1.82

1.52

4.8

4.0

5.9

5.8

mmol/l

0.64

126

1132

(3012516) Albumin [Mass/volume] in Urine

293

1.55

1.51

3.6

3.0

14.9

279.9

mg/l

0.61

181

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

447

1.48

1.50

3.1

3.6

47.3

25.5

ng/l

0.31

286

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

250

1.58

1.50

1.9

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

134

1.75

1.49

1.7

1.9

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.39

1.46

1.3

1.7

0.2

g/l

—

(3022621) pH of Urine by Test strip

1.89

1.43

2.4

2.5

—

(3002256) Pathology report gross observation

152

1.69

1.43

1.5

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

128

1.74

1.42

1.7

1.9

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

131

1198

1.71

1.41

14.1

11.1

84.4

84.8

ml/min/173m2

0.08

116

968

(3015736) pH of Urine

480

1.45

1.41

3.0

3.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.27

1.39

2.2

2.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

334

1.49

1.39

2.1

1.6

1.5

1.3

mmol/l

0.68

280

(3035350) Ketones [Presence] in Urine by Test strip

615

1.44

1.38

3.3

3.5

0.0

estimate

—

122

(3018095) Leukocytes [#/volume] in Urine

426

1.46

1.37

2.9

3.4

28.0

54.7

e6/l

0.65

284

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.00

1.37

1.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

213

1.57

1.35

1.7

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

137

1272

1.83

1.34

5.3

4.5

2.9

2.8

mmol/l

0.67

127

1171

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.16

1.33

1.3

1.6

1.3

1.2

g/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.84

1.29

1.0

1.2

—

(3004616) Nuclear Ab [Presence] in Serum

2.84

1.29

1.6

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

412

1.44

1.29

2.4

2.8

—

(3014051) Protein [Presence] in Urine by Test strip

2.36

1.20

1.2

2.1

—

(36660697) Celiac disease serology panel - Serum

1.77

1.19

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

185

1.56

1.19

1.7

1.9

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

142

1348

1.90

1.17

13.1

9.3

25.5

24.8

u/l

0.26

135

1299

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

212

1.52

1.16

3.6

3.2

31.0

104.9

ng/l

1.27

152

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

130

1203

1.58

1.13

4.1

3.7

1.3

1.2

mmol/l

0.96

123

1111

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.43

1.10

1.2

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

136

1274

1.68

1.09

16.1

12.3

18.5

23.4

mg/l

1.34

119

985

(3045414) Leukocytes [Presence] in Urine

1.99

1.09

1.3

1.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

277

1.44

1.08

1.3

1.2

0.6

1.9

u/ml

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.31

1.04

3.2

2.9

4.1

5.5

e9/l

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.31

1.04

2.8

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.78

1.02

1.3

—

47.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.73

1.02

1.1

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.05

1.01

1.3

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.21

0.99

3.6

3.7

62.4

62.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.27

0.94

1.0

1.3

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.19

0.92

2.0

2.5

25.9

25.2

mmol/l

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.19

0.92

1.0

1.8

5.0

3.8

g/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

277

1.39

0.91

3.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.11

0.90

1.0

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.95

0.90

1.1

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.95

0.90

1.1

1.0

—

(3009261) Glucose [Presence] in Urine by Test strip

628

1.31

0.89

3.5

0.0

estimate

—

119

(42529406) Shigella sp [Presence] in Stool by Culture

1.91

0.89

1.1

—

(40768443) Skin Pathology biopsy report

1.91

0.89

1.3

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.72

0.88

3.2

1.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.65

0.88

2.4

—

19.7

—

(3019150) Specific gravity of Urine by Refractometry

262

1.38

0.85

3.4

3.6

1.0

kg/l

—

(3000330) Specific gravity of Urine by Test strip

1.75

0.85

1.7

3.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

140

1335

1.67

0.84

18.1

14.1

71.8

71.1

umol/l

0.20

140

1335

(3019225) pH of Specimen

1.63

0.84

2.9

3.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

622

1.30

0.84

4.9

5.0

0.0

estimate

—

123

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

124

1156

1.41

0.83

6.9

5.0

39.5

38.8

mmol/mol

0.36

117

1086

(3023511) Choriogonadotropin [Units/volume] in Urine

1.91

0.82

2.2

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

273

1.37

0.81

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

193

1.42

0.80

1.7

1.6

1271.5

1309.9

nmol/l

0.09

147

(3013650) Neutrophils [#/volume] in Blood by Automated count

714

1.29

0.80

10.4

9.6

3.9

4.0

e9/l

0.41

628

(3049717) Cytology report of Urine Cyto stain

1.80

0.77

2.3

1.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.12

0.75

1.4

1.2

—

(1002224) Polysomnography panel

1.68

0.75

1.2

1.1

—

(40768797) Stomach Pathology biopsy report

161

1.43

0.73

1.1

1.2

—

(3011288) Drugs identified in Urine by Screen method

2.03

0.73

28.0

1.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

1.95

0.71

2.8

3.0

4.9

5.3

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

1.95

0.71

2.8

3.0

10.5

8.5

kpa

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.74

0.71

2.1

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

363

1.30

0.71

2.4

2.8

20.3

73.5

e6/l

1.44

269

(3000764) Benzodiazepines [Presence] in Urine

1.70

0.69

4.3

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.70

0.69

4.1

1.4

—

(3027008) Opiates [Presence] in Urine

1.70

0.69

4.3

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

479

1.27

0.68

3.3

3.6

—

(3027944) Amphetamines [Presence] in Urine

1.66

0.68

4.3

1.3

—

(3023368) Bacteria identified in Blood by Culture

309

1.31

0.68

5.5

3.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.66

0.67

2.3

3.5

5.0

5.2

kpa

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

1.81

0.67

1.8

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.81

0.67

2.2

1.6

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

1.62

0.66

1.4

1.2

—

2.5

—

(40768804) Tissue Pathology biopsy report

510

1.26

0.65

2.4

1.9

—

(3026008) Bacteria identified in Urine by Culture

367

1.28

0.65

3.2

2.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.75

0.64

1.0

1.8

—

(4035726)

113

1.47

0.64

1.3

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.63

0.62

1.4

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

1.69

0.62

1.4

2.4

3.6

4.2

umol/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

304

1.29

0.61

3.3

3.0

674.1

1146.3

ng/l

0.81

254

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.57

0.61

1.1

1.0

—

(1761868) Lipid panel - Serum or Plasma

495

1.24

0.60

3.1

2.7

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.74

0.58

1.2

1.1

—

4.2

—

(3021589) Normoblasts [#/volume] in Blood

565

1.23

0.57

13.3

8.5

0.0

e9/l

0.80

463

(3052851) Hemolysis interference index of Serum or Plasma

1.65

0.56

2.7

2.5

—

(36304419) Bacteria [Presence] in Urine

327

1.26

0.55

2.4

2.6

—

(3000991) Gas panel - Venous blood

1.52

0.55

5.0

7.0

—

(3022313) Gas panel - Capillary blood

1.60

0.55

1.7

3.8

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.48

0.53

2.8

2.5

66.8

68.4

g/l

0.54

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

181

1.32

0.52

2.0

2.5

0.9

3.1

e6/l

1.66

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

229

1.27

0.48

1.8

1.7

400.7

452.7

pmol/l

0.78

204

(3003694) ABO and Rh group [Type] in Blood

358

0.80

0.47

1.3

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

131

1.34

0.44

3.7

3.0

—

(3033658) Prothrombin time (PT) actual/Normal

307

1.23

0.44

3.7

2.9

102.3

95.6

0.77

300

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.40

0.42

7.6

7.8

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.40

0.41

3.7

4.9

0.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.49

0.40

5.4

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.40

0.0

1.1

—

(3026782) Osmolality of Urine

235

1.24

0.40

2.3

2.5

526.0

554.3

mosm/kgh2o

0.22

205

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.39

0.39

6.4

4.6

24.9

25.0

mmol/l

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.38

0.39

4.0

5.1

0.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

302

1.21

0.38

4.2

4.8

—

(40761511) CBC panel - Blood by Automated count

138

1342

1.33

0.38

14.9

11.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

135

1.29

0.37

39.1

22.3

—

1.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.28

0.37

1.2

1.4

36.1

27.4

iu/l

—

(3036489) Thrombin time

1.48

0.36

1.2

1.6

21.0

20.8

—

(4010399)

1.37

0.35

1.2

1.3

—

(3017181) Myelocytes/100 leukocytes in Blood

100

1.33

0.35

3.8

4.7

0.8

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.38

0.35

1.5

2.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

164

1.25

0.35

1.9

2.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

192

1.23

0.34

2.0

2.4

0.5

0.8

e6/l

0.88

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

137

1.27

0.34

1.3

1.5

—

(3003338) MCHC [Mass/volume]

106

1107

0.86

0.33

21.6

15.9

331.5

331.9

g/l

0.20

106

1102

(3025159) Blasts/100 leukocytes in Blood

1.35

0.33

4.2

5.3

0.0

—

(3012544) pH of Venous blood

101

1.31

0.33

3.1

2.8

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.29

0.32

1.3

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.29

0.32

1.3

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.29

0.32

1.3

1.5

—

(3020891) Body temperature

1.29

0.32

5.2

4.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.29

0.32

1.3

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.36

0.31

1.9

2.9

0.9

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

289

1.18

0.31

1.7

1.6

0.8

1.1

mg/l

0.88

234

(3015171) Extractable nuclear Ab [Units/volume] in Serum

1.29

0.30

1.3

—

5.2

—

(3044640) Blood type and Crossmatch panel - Blood

379

1.15

0.28

2.1

2.0

—

(40761536) Microorganisms panel - Urine sediment

106

1.25

0.24

3.5

3.4

—

(3016879) Cocaine [Presence] in Urine

1.33

0.23

5.4

1.4

—

(40758558) Short blood count panel - Blood

316

1.14

0.23

8.8

6.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.26

0.22

1.2

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.26

0.22

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

2.3

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(44813793)

0.00

0.21

0.0

1.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.27

0.21

1.7

1.3

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

16.2

—

1831.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

9.3

—

973.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

242

1.14

0.20

1.9

1.3

2.0

2.3

g/l

0.59

150

(3029937) Albumin [Presence] in Urine by Test strip

330

1.12

0.19

3.5

0.0

estimate

—

122

(3044889) 12 lead EKG panel

856

1.10

0.18

3.8

3.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.20

0.18

1.4

1.3

—

(40761535) Cells panel - Urine sediment

1.23

0.18

3.0

3.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.17

0.17

1.1

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

589

1.09

0.16

3.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.21

0.16

1.4

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

334

1.10

0.15

2.6

2.7

0.2

0.5

e6/l

0.89

240

(3009542) Hematocrit [Volume Fraction] of Blood

120

1177

1.10

0.13

17.6

13.1

39.8

39.3

0.29

890

(3041096) Erythrocytes [Presence] in Urine by Automated

357

1.09

0.13

3.1

3.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.17

0.10

1.4

—

(3005033) Fetal Nuchal fold Thickness US

1.17

0.10

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.11

0.10

1.6

1.5

—

(3022145) Colonoscopy Study observation

145

1.12

0.10

1.4

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

282

1.08

0.09

2.2

2.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.12

0.09

1.5

1.6

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.09

0.09

3.2

6.0

1.4

1.5

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.09

0.09

3.2

6.1

1.0

0.9

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.04

0.08

1.0

2.3

4.5

2.6

mg/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.83

0.08

1.0

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.80

0.08

4.0

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.10

0.07

3.1

2.2

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.07

0.07

7.5

8.1

24.9

25.2

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

147

1.10

0.07

2.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.04

0.07

1.6

—

(3042936) Bacteria identified in Isolate by Culture

162

0.92

0.06

1.9

2.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

130

1.08

0.05

1.8

—

(21494755) Public health laboratory ask at order entry panel

140

0.92

0.04

1.1

1.3

—

(3016502) Oxygen saturation in Arterial blood

111

1.09

0.04

7.1

7.7

96.8

95.5

0.79

106

(3000492) Spirometry study

112

1.08

0.03

1.6

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

133

1.06

0.01

1.8

1.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

183

1.04

0.01

3.5

3.9

16.5

22.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

867

0.98

0.01

3.1

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

246

0.97

0.00

2.2

1.9

—

(3027801) Oxygen [Partial pressure] in Arterial blood

127

1.03

0.00

6.6

7.2

12.3

12.2

kpa

0.03

122

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

127

1.03

0.00

6.6

7.2

5.2

kpa

0.02

122

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

138

1.02

0.00

8.1

8.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.06

0.00

2.9

1.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.00

0.00

1.5

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.7

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.1

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.2

—

10.2

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

0.0

1.3

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40768793) Breast Pathology biopsy report

0.98

0.00

1.0

1.3

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

156.6

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.5

—

8.3

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(4198724)

0.00

0.0

1.1

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.96

0.00

1.6

1.7

0.6

1.7

ug/l

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.4

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(3019060) Gas panel - Arterial blood

0.92

0.00

5.3

5.0

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

130

1.00

0.00

3.5

2.9

0.6

0.7

ug/l

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.0

—

(3013293) Extractable nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

21.3

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.89

0.00

1.9

1.3

231.3

191.4

u/ml

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

10.7

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

12.9

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.4

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40761539) Cells [Type] in Urine sediment by Light microscopy

0.00

0.0

1.2

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

6.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITACU and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_THYROIDITACU	1.181 [0.92, 1.52]	0.199
Birth year	0.999 [0.99, 1.01]	0.739

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITACU.

N-year risk	Females	Males
1	0.117%	No data
5	0.776%	No data
10	1.927%	No data
15	3.803%	No data
20	6.664%	No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITACU – Acute thyroiditis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acute thyroiditis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints