No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
151 |
4. Check minimum number of eventsNone |
151 |
5. Include endpointsNone |
151 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis acuta
Similar endpoints
↥List of similar endpoints to
Acute thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1138 | 842 | 289 |
| Only index persons | 1081 | 812 | 269 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.43 | 45.51 | 49.44 |
| Only index persons | 45.78 | 44.95 | 48.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | 116 | 35 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 46.66 | 45.10 | 51.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
174.6
127
*
H03AA01
ATC
levothyroxine sodium; systemic
76.6
59.0
65
16
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
33.8
31
*
104
Kela drug reimbursment
Thyroid insufficiency
304.0
25.6
25
*
H03BB01
ATC
carbimazole; oral
289.2
24.5
24
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
45.7
19.3
23
6
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
19.2
18
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
15.9
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
13.7
15.1
26
23
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
14.9
14
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
142.7
12.7
13
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
71.3
11.8
13
*
H02AB06
ATC
prednisolone; systemic
3.2
9.8
82
436
E03.89
ICD-10 Finland
Other specified hypothyroidism
+∞
9.5
9
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
9.5
9
*
H02AB07
ATC
prednisone; oral
4.2
8.6
34
99
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
95.8
8.5
9
*
2450A
ICD-9 Finland
Thyroiditis, Acute thyroiditis
+∞
7.4
7
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
7.4
7
*
T86
ICPC
Hypothyroidism/myxoedema
42.2
6.8
8
*
J01FA06
ATC
roxithromycin; oral
2.6
6.5
68
380
C07AA05
ATC
propranolol; systemic
3.0
6.2
40
165
R03AC02
ATC
salbutamol; inhalant
2.5
6.2
84
536
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITACU | 1.181 [0.92, 1.52] | 0.199 |
| Birth year | 0.999 [0.99, 1.01] | 0.739 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | No data |
| 5 | 0.776% | No data |
| 10 | 1.927% | No data |
| 15 | 3.803% | No data |
| 20 | 6.664% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITACU – Acute thyroiditis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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