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Unspecified organic or symptomatic mental disorder

DOID EFO Endpoint Browser PheWeb

F5_UNSORG

cognitive disorder: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F09
  • Cause of death: ICD-10 — F09

2 out of 7 registries used, show all original rules.

141

4. Check minimum number of events

None

141

5. Include endpoints

None

141

6. Filter based on genotype QC (FinnGen only)

134

Control definitions (FinnGen only)

Control exclude
F5_ORGANIC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F04-F09
Name in latin
Perturbatio mentis organica sive symptomatica non specificata

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2094 1063 995
Only index persons 1489 777 712
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 68.08 72.57 63.10
Only index persons 64.41 69.43 58.93

-FinnGen-

Key figures

All Female Male
Number of individuals 134 58 76
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 67.59 65.83 68.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
141
Matched controls
1410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F09
ICD-10 Finland
Unspecified organic or symptomatic mental disorder
+∞
200.6
140
*
N05AX08
ATC
risperidone; systemic
24.5
73.9
63
45
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
22.9
61.2
51
34
N05AH03
ATC
olanzapine; systemic
29.5
58.1
42
20
N05AH04
ATC
quetiapine; oral
10.1
39.7
60
96
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
25.8
24
*
N05BA06
ATC
lorazepam; systemic, sublingual
10.6
24.6
30
35
N06DX01
ATC
memantine; oral
150.6
24.5
25
*
F03
ICD-10 Finland
Unspecified dementia
100.6
23.5
25
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
26.1
22.5
31
15
N03AG01
ATC
valproic acid; systemic, rectal
19.3
21.0
32
21
N05BA04
ATC
oxazepam; oral
5.1
20.1
66
209
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.3
17.6
29
48
N06AB04
ATC
citalopram; systemic
4.6
16.1
53
164
R41.0
ICD-10 Finland
Disorientation, unspecified
30.5
16.1
21
8
F05.9
ICD-10 Finland
Delirium, unspecified
96.0
15.9
17
*
N05AX12
ATC
aripiprazole; systemic
22.1
14.8
21
11
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.5
14.2
32
72
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
59.7
14.1
16
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
25.5
13.3
18
8
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
6.5
11.4
20
35
N05AD01
ATC
haloperidol; systemic
13.5
11.2
19
16
N06DA02
ATC
donepezil; oral
47.4
11.1
13
*
N06DA03
ATC
rivastigmine; oral, transdermal
118.5
10.6
11
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
+∞
10.5
10
*
N05AA02
ATC
levomepromazine; systemic
10.8
10.1
19
20
F05.8
ICD-10 Finland
Other delirium
59.2
9.8
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
9.8
64
298
IGY99
NOMESCO Finland
Other psychiatric treatment contact
32.5
9.6
12
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
9.5
9
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
10.1
9.4
18
20
N03AX09
ATC
lamotrigine; oral
11.9
9.1
16
15
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.9
8.7
21
49
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
29.6
8.6
11
*
N05BA01
ATC
diazepam; systemic, rectal
3.6
8.5
32
105
G30.8
ICD-10 Finland
Other Alzheimer disease
95.5
8.5
9
*
A28
ICPC
Limited function/disability NOS
3.3
8.4
40
153
T36
ICD-10 Finland
Poisoning by systemic antibiotics
11.8
8.0
14
13
AA1AD
NOMESCO Finland
CT of head and brain
2.9
7.9
49
217
N06AX11
ATC
mirtazapine; oral
2.8
7.8
57
275
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
26.7
7.7
10
*
F22.0
ICD-10 Finland
Delusional disorder
26.7
7.7
10
*
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
+∞
7.3
7
*
N06AB03
ATC
fluoxetine; oral
3.7
7.3
26
82
N03AE01
ATC
clonazepam; systemic
7.7
7.2
16
23
N05CD07
ATC
temazepam; oral
3.2
7.2
34
128
N05AH02
ATC
clozapine; systemic
13.0
7.2
12
10
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.9
7.2
13
13
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
7.2
19
48
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
6.8
7.0
17
28
N05AB03
ATC
perphenazine; systemic, rectal
10.1
7.0
13
14
R53
ICD-10 Finland
Malaise and fatigue
2.8
6.9
44
196
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
17.8
6.8
10
6
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
17.8
6.8
10
6
SPAT1254
SPAT
Administration of medicine
3.2
6.6
30
110
N05CF01
ATC
zopiclone; oral
2.5
6.6
62
334
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
6.5
33
129
R44.3
ICD-10 Finland
Hallucinations, unspecified
73.0
6.5
7
*
N06DA04
ATC
galantamine; oral
73.0
6.5
7
*
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
73.0
6.5
7
*
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
73.0
6.5
7
*
N06AX16
ATC
venlafaxine; oral
3.3
6.5
27
94
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.4
6.4
17
43
N05AN01
ATC
lithium; oral
19.1
6.3
9
5
A06AD11
ATC
lactulose; oral
2.8
6.3
38
164
F06.0
ICD-10 Finland
Organic hallucinosis
+∞
6.3
6
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
13.3
6.2
10
8
N06AB06
ATC
sertraline; oral
3.5
6.1
23
75
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.4
6.1
16
40

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
288
2.64
7.03
2.9
1.9
445.18
216.35
u/l
0.46
51
273
40
169
2.91
6.94
1.8
1.7
1125.10
1187.33
nmol/l
0.15
27
132
74
460
2.28
5.46
10.5
6.6
1.23
1.21
mmol/l
0.89
64
393
68
426
2.15
4.73
9.0
5.5
1.22
1.21
mmol/l
0.87
62
391
51
292
2.17
4.41
6.9
4.0
7.40
7.40
ph
—
8
55
7
6
12.18
4.32
19.6
1.7
—
—
—
0
0
49
288
2.07
3.89
3.0
3.0
—
—
—
0
0
48
284
2.05
3.72
6.7
4.4
—
—
—
0
0
9
17
5.58
3.57
24.2
1.3
—
—
—
0
0
57
368
1.92
3.39
2.9
2.0
91.94
93.11
pmol/l
0.05
26
192
51
321
1.92
3.25
2.9
3.3
2.34
2.35
mmol/l
0.25
42
284
9
20
4.73
3.17
15.4
1.2
—
—
—
0
0
6
8
7.77
3.08
1.5
1.1
—
—
—
0
0
38
222
1.97
2.98
1.7
1.6
19.70
23.40
nmol/l
0.76
32
186
9
22
4.29
2.93
15.4
1.2
—
—
—
0
0
9
22
4.29
2.93
15.9
1.2
—
—
—
0
0
61
419
1.80
2.90
10.1
5.9
0.52
0.64
%
0.84
54
381
9
23
4.11
2.83
12.3
1.2
—
—
—
0
0
9
23
4.11
2.83
15.4
1.2
—
—
—
0
0
17
73
2.51
2.78
3.6
3.2
5.32
4.31
kpa
1.14
17
68
7
15
4.85
2.63
19.6
1.1
—
—
—
0
0
5
8
6.43
2.39
30.8
19.0
1299.00
1255.50
nmol/l
—
5
8
64
465
1.69
2.39
8.8
6.1
0.04
0.04
e9/l
0.25
50
401
62
448
1.69
2.35
8.9
6.2
25.91
26.93
%
0.27
55
412
61
439
1.69
2.35
10.2
6.3
8.60
8.59
%
0.01
54
405
59
422
1.68
2.32
10.1
6.9
—
—
—
0
0
63
460
1.67
2.28
9.0
6.2
0.64
0.60
e9/l
0.58
50
398
65
479
1.66
2.27
12.5
6.4
0.19
0.19
e9/l
0.01
50
422
12
48
2.64
2.25
2.9
7.2
—
—
—
0
0
60
434
1.67
2.25
8.9
5.9
2.56
2.70
%
0.20
53
398
64
472
1.65
2.22
10.4
6.2
1.93
1.91
e9/l
0.05
52
424
61
445
1.65
2.20
8.6
5.8
58.34
58.35
%
0.00
54
412
25
143
1.91
2.06
2.8
3.1
3.81
3.69
e6/l
0.02
12
81
21
115
1.97
1.96
6.4
6.6
3.03
1.16
mmol/l
1.22
13
86
6
16
3.87
1.95
1.5
1.4
—
—
—
0
0
7
22
3.29
1.90
6.1
5.2
—
—
—
0
0
55
404
1.59
1.87
5.0
4.3
35.55
35.08
g/l
0.24
49
380
71
558
1.55
1.78
16.8
10.2
4.77
4.21
e9/l
0.84
58
479
36
241
1.66
1.76
11.0
8.1
—
—
—
0
0
80
651
1.53
1.68
5.3
4.3
—
—
—
0
0
30
200
1.64
1.48
3.4
3.2
446.08
545.39
mosm/kgh2o
1.30
25
168
28
404
0.62
1.47
2.2
2.2
—
—
—
0
0
7
28
2.58
1.47
1.6
3.9
—
—
—
0
0
41
296
1.54
1.46
6.9
3.1
5.81
7.51
mmol/l
1.33
32
248
5
124
0.38
1.45
1.6
1.4
—
—
—
0
0
80
930
0.68
1.44
4.9
4.5
4.26
4.53
mmol/l
1.78
73
844
5
17
3.01
1.37
3.2
3.6
67.00
58.71
%
—
5
17
5
17
3.01
1.37
2.8
3.4
7.35
4.79
e9/l
—
5
17
80
923
0.69
1.32
5.0
4.5
1.32
1.44
mmol/l
2.40
72
834
63
508
1.43
1.28
5.3
6.6
9.57
12.35
umol/l
1.23
57
486
53
414
1.45
1.27
16.5
10.3
0.00
0.00
e9/l
0.56
44
332
10
49
2.12
1.25
2.3
3.7
—
—
—
0
0
19
120
1.67
1.16
8.9
6.6
98.79
104.10
mmol/l
1.39
19
120
78
893
0.72
1.13
4.3
4.0
1.42
1.28
mmol/l
0.72
69
805
60
489
1.40
1.12
24.2
14.9
1.38
1.30
inr
0.24
20
139
5
21
2.43
1.10
9.8
3.4
—
—
—
0
0
22
315
0.64
1.09
3.5
3.1
—
—
—
0
0
5
22
2.32
1.04
6.2
3.0
118.60
127.29
g/l
—
5
14
10
53
1.95
1.04
6.6
5.8
24.41
25.06
mmol/l
—
10
53
39
298
1.43
1.04
4.1
3.9
8.33
7.75
mg/mmol
0.04
24
188
0
31
0.00
0.97
0.0
1.1
—
—
—
0
0
13
78
1.73
0.95
4.6
6.4
—
—
—
0
0
6
29
2.12
0.90
3.8
4.5
—
—
—
0
0
31
235
1.41
0.86
2.8
1.9
2.86
3.39
mg/l
0.75
25
208
86
952
0.75
0.85
5.3
5.0
2.43
2.65
mmol/l
1.50
72
861
36
282
1.37
0.83
3.3
3.2
76.75
274.57
mg/l
0.42
24
183
11
66
1.72
0.81
9.1
4.4
—
—
—
0
0
20
141
1.49
0.80
2.3
1.7
—
—
—
0
0
6
33
1.85
0.80
1.2
1.1
—
—
—
0
0
18
124
1.52
0.80
1.7
1.5
—
—
—
0
0
24
176
1.44
0.79
1.4
1.4
2.02
2.67
g/l
0.89
11
110
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
46
377
1.33
0.79
3.2
3.7
6.20
5.70
ph
—
5
27
5
23
2.22
0.77
5.6
3.2
7.32
8.31
kpa
—
5
23
38
304
1.34
0.76
4.1
3.3
211.35
227.59
e6/l
0.02
27
240
74
651
1.29
0.75
4.2
3.9
—
—
—
0
0
20
145
1.44
0.70
1.7
2.1
—
—
—
0
0
54
459
1.29
0.70
3.6
3.9
0.00
0.00
estimate
—
10
92
75
665
1.27
0.70
4.8
4.0
14.89
15.02
pmol/l
0.14
69
602
24
181
1.39
0.69
3.3
2.7
2.47
2.46
mmol/l
0.16
19
153
45
375
1.29
0.68
5.4
4.3
35.18
37.10
ng/l
0.05
37
273
54
461
1.28
0.68
3.6
4.0
0.00
0.00
estimate
—
10
82
53
455
1.26
0.63
4.8
5.3
0.00
0.00
estimate
—
10
87
32
259
1.30
0.60
3.2
3.6
—
—
—
0
0
0
23
0.00
0.59
0.0
1.8
—
—
—
0
0
27
214
1.32
0.58
3.0
3.8
—
—
—
0
0
78
710
1.22
0.52
4.3
4.2
12.46
12.92
mm/h
0.08
69
641
9
65
1.41
0.52
6.4
2.8
—
—
—
0
0
37
314
1.24
0.48
1.8
2.4
—
—
—
0
0
14
103
1.40
0.47
1.6
1.6
—
—
—
0
0
33
278
1.24
0.45
4.2
3.2
0.19
0.53
e6/l
1.36
23
214
12
87
1.41
0.44
7.8
3.7
—
—
—
0
0
32
270
1.24
0.44
4.3
3.1
—
—
—
0
0
5
32
1.58
0.42
1.4
2.3
2.02
1.61
mg/l
—
5
27
8
59
1.38
0.42
14.5
7.8
93.57
95.41
%
—
8
59
0
15
0.00
0.41
0.0
4.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
7
103
0.66
0.41
1.3
1.3
—
—
—
0
0
16
124
1.33
0.41
1.1
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
13.04
—
0
12
9
70
1.30
0.37
1.8
1.2
—
—
—
0
0
33
378
0.83
0.36
4.1
5.1
1.59
2.86
ug/l
1.79
28
327
12
91
1.35
0.35
2.3
1.5
—
—
—
0
0
6
88
0.67
0.34
1.7
1.3
—
—
—
0
0
16
128
1.28
0.33
1.7
1.6
—
—
—
0
0
11
142
0.76
0.32
1.2
1.4
—
10.70
—
0
62
96
1005
0.86
0.31
27.6
17.4
81.55
79.90
umol/l
0.09
96
1005
90
853
1.15
0.31
6.0
4.5
1.96
1.86
mu/l
0.34
82
748
101
1051
0.86
0.29
42.2
22.0
7.39
6.79
e9/l
1.97
93
1012
101
1050
0.87
0.28
41.6
22.0
4.36
4.48
e12/l
1.19
92
1012
101
1050
0.87
0.28
41.6
21.9
38.41
39.97
%
1.28
92
994
94
981
0.87
0.27
24.8
13.7
—
—
—
0
0
101
1049
0.87
0.27
41.8
22.0
254.45
245.68
e9/l
0.74
96
1016
8
67
1.21
0.27
1.4
1.6
—
—
—
0
0
5
38
1.33
0.23
1.4
2.2
—
—
—
0
0
5
39
1.29
0.23
19.4
5.2
—
—
—
0
0
95
914
1.12
0.22
5.5
4.8
6.54
5.99
mmol/l
1.55
83
821
0
11
0.00
0.21
0.0
1.3
—
196.62
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.05
—
0
7
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
35
383
0.89
0.21
3.7
2.5
111.77
116.19
ug/l
0.05
30
349
38
348
1.13
0.21
4.9
3.8
29.70
36.09
e6/l
0.15
27
252
11
131
0.83
0.18
1.8
1.4
—
—
—
0
0
10
82
1.24
0.17
5.1
3.8
—
—
—
0
0
7
62
1.14
0.17
1.7
2.6
—
—
—
0
0
22
244
0.88
0.16
1.5
1.4
—
—
—
0
0
97
947
1.08
0.12
26.7
15.1
26.65
25.79
mg/l
0.11
85
754
7
66
1.06
0.08
1.0
1.6
—
—
—
0
0
31
294
1.07
0.08
4.9
3.8
—
—
—
0
0
9
86
1.05
0.07
4.4
3.4
—
—
—
0
0
28
269
1.05
0.04
4.1
4.1
0.00
0.00
estimate
—
7
82
14
146
0.95
0.00
1.1
1.3
11.94
45.42
iu/ml
—
5
51
26
264
0.98
0.00
2.3
3.0
326.40
7500.40
umol/l
1.57
15
226
88
885
0.98
0.00
8.6
5.9
43.65
40.50
mmol/mol
1.28
78
823
11
105
1.05
0.00
1.6
1.9
117.98
148.44
ug/g
—
5
86
5
58
0.86
0.00
3.4
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.63
—
0
6
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
12.33
—
0
7
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
0.86
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
41.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.5
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
42.20
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_UNSORG and mortality.

Females

Parameter HR [95% CI] p-value
F5_UNSORG 3.123 [2.53, 3.86] < 0.001
Birth year 0.996 [0.99, 1.0] 0.371

During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 887 females with F5_UNSORG died.

Males

Parameter HR [95% CI] p-value
F5_UNSORG 3.978 [2.97, 5.33] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 830 males with F5_UNSORG died.

Mortality risk

Mortality risk for people of age

years, who have F5_UNSORG.

N-year risk Females Males
1 0.285% 0.828%
5 1.639% 4.349%
10 4.299% 11.111%
15 9.38% 19.664%
20 14.909% 33.032%

Relationships between endpoints

↥

Index endpoint: F5_UNSORG – Unspecified organic or symptomatic mental disorder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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