Unspecified organic or symptomatic mental disorder

F5_UNSORG

cognitive disorder: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F09 Cause of death: ICD-10 — F09 2 out of 7 registries used, show all original rules.	138
4. Check minimum number of events None	138
5. Include endpoints None	138
6. Filter based on genotype QC (FinnGen only)	138

Control definitions (FinnGen only)

Control exclude: F5_ORGANIC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F04-F09
Name in latin: Perturbatio mentis organica sive symptomatica non specificata

NAME	F5_UNSORG
CONTROL_EXCLUDE	F5_ORGANIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F09
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F09
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Unspecified organic or symptomatic mental disorder based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2094	1063	995
Only index persons	1489	777	712
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	68.08	72.57	63.10
Only index persons	64.41	69.43	58.93

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	138	62	76
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	67.50	67.33	67.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
122: Matched controls
1220

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F09

ICD-10 Finland

Unspecified organic or symptomatic mental disorder

+∞

173.0

121

N05AX08

ATC

risperidone; systemic

21.6

33.3

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

17.3

27.8

N05AH03

ATC

olanzapine; systemic

37.1

26.2

N05AH04

ATC

quetiapine; oral

9.9

22.8

F29

ICD-10 Finland

Unspecified nonorganic psychosis

32.5

21.6

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

+∞

21.5

F03

ICD-10 Finland

Unspecified dementia

53.1

19.0

N06DX01

ATC

memantine; oral

78.9

18.3

N03AG01

ATC

valproic acid; systemic, rectal

15.4

14.7

N05BA04

ATC

oxazepam; oral

5.3

14.3

155

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

45.5

13.5

F05.9

ICD-10 Finland

Delirium, unspecified

144.2

12.7

N06AB04

ATC

citalopram; systemic

4.9

12.3

133

N05AX12

ATC

aripiprazole; systemic

14.8

11.6

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

8.4

11.3

N05BA06

ATC

lorazepam; systemic, sublingual

9.3

10.7

R41.0

ICD-10 Finland

Disorientation, unspecified

13.9

10.2

N06DA02

ATC

donepezil; oral

44.0

10.2

F05.8

ICD-10 Finland

Other delirium

+∞

9.5

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.6

9.2

214

N05AD01

ATC

haloperidol; systemic

20.5

9.2

G30.1

ICD-10 Finland

Alzheimer disease with late onset

22.0

8.7

F32.9

ICD-10 Finland

Depressive episode, unspecified

5.7

8.6

R53

ICD-10 Finland

Malaise and fatigue

3.9

8.3

121

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

7.6

8.3

F20.9

ICD-10 Finland

Schizophrenia, unspecified

18.8

8.3

F22.0

ICD-10 Finland

Delusional disorder

36.0

8.2

N05AA02

ATC

levomepromazine; systemic

8.4

8.0

N03AE01

ATC

clonazepam; systemic

8.6

7.7

N05BA01

ATC

diazepam; systemic, rectal

3.9

7.3

N06AX11

ATC

mirtazapine; oral

3.2

7.3

188

F31.7

ICD-10 Finland

Bipolar affective disorder, currently in remission

32.1

7.3

A28

ICPC

Limited function/disability NOS

3.9

7.1

N06DA03

ATC

rivastigmine; oral, transdermal

42.5

6.8

N05AH02

ATC

clozapine; systemic

15.4

6.5

F20

ICD-10 Finland

Schizophrenia

73.5

6.5

N05AB03

ATC

perphenazine; systemic, rectal

10.1

6.5

F10.20

ICD-10 Finland

Alcohol dependence currently independent

19.2

6.4

F00.10*G30.1

ICD-10 Finland

Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms

+∞

6.3

T36

ICD-10 Finland

Poisoning by systemic antibiotics

7.9

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019309) Folate [Moles/volume] in Red Blood Cells

170

2.80

6.36

1.8

1125.1

1176.8

nmol/l

0.12

133

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

288

2.44

5.78

3.0

1.9

468.4

224.9

u/l

0.46

274

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

457

2.14

4.61

8.6

6.5

1.2

mmol/l

1.18

385

(3028707) Methadone [Presence] in Urine by Screen method

12.19

4.32

19.6

1.7

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

422

2.02

3.96

7.0

5.4

1.2

mmol/l

1.08

381

(3011288) Drugs identified in Urine by Screen method

5.58

3.57

24.4

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.57

3.56

3.2

3.8

—

(3018418) pH of Serum or Plasma

289

2.01

3.54

4.1

7.4

—

(3023368) Bacteria identified in Blood by Culture

278

1.98

3.33

5.5

4.4

—

(3016879) Cocaine [Presence] in Urine

4.74

3.17

15.4

1.2

—

(3023410) Appearance of Cerebral spinal fluid

7.77

3.08

1.5

1.1

—

(3026008) Bacteria identified in Urine by Culture

287

1.90

2.99

3.0

3.1

—

(3028300) Cannabinoids [Presence] in Urine

4.30

2.94

15.9

1.2

—

(3027008) Opiates [Presence] in Urine

4.30

2.94

15.4

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

317

1.85

2.83

2.9

3.2

2.3

mmol/l

0.06

277

(3027944) Amphetamines [Presence] in Urine

4.11

2.83

12.3

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

4.11

2.83

15.4

1.2

—

(3002032) Base excess in Venous blood by calculation

2.41

2.67

3.2

4.3

2.2

2.0

mmol/l

0.09

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

375

1.78

2.65

2.9

2.0

91.9

92.4

pmol/l

0.02

202

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.85

2.63

19.6

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

7.35

2.57

30.8

21.4

1299.0

1120.9

nmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.76

2.43

2.9

6.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

231

1.82

2.35

1.7

1.6

18.3

23.0

nmol/l

1.32

193

(3022096) Basophils/100 leukocytes in Blood

415

1.69

2.29

10.3

5.9

0.5

0.6

0.84

377

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.69

2.15

1.1

1.0

—

(3003396) Base excess in Arterial blood by calculation

111

2.05

2.15

6.4

2.4

1.1

mmol/l

1.11

(3044290) Cell count panel - Cerebral spinal fluid

3.87

1.95

1.5

1.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.22

1.94

4.0

3.2

5.2

4.3

kpa

0.99

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.90

0.0

1.5

—

(3002030) Lymphocytes/100 leukocytes in Blood

443

1.58

1.83

9.1

6.2

25.9

27.1

0.30

406

(3012544) pH of Venous blood

2.10

1.83

3.9

4.3

—

(3019069) Monocytes/100 leukocytes in Blood

434

1.58

1.83

10.4

6.3

8.5

8.6

0.18

401

(3006315) Basophils [#/volume] in Blood

462

1.57

1.83

9.0

6.1

0.0

e9/l

0.38

398

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

283

1.64

1.79

4.3

3.0

34.2

33.4

u/l

0.06

270

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.60

1.77

1.4

1.2

—

(3001604) Monocytes [#/volume] in Blood

456

1.56

1.75

9.1

6.2

0.6

e9/l

0.54

393

(3013115) Eosinophils [#/volume] in Blood

475

1.55

1.75

12.8

6.4

0.2

e9/l

0.05

419

(3006504) Eosinophils/100 leukocytes in Blood

429

1.56

1.73

9.0

5.9

2.6

2.7

0.10

393

(42870588) Differential panel, method unspecified - Blood

294

1.62

1.73

7.1

5.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

144

1.81

1.72

2.8

3.1

3.8

3.7

e6/l

0.02

(3019198) Lymphocytes [#/volume] in Blood

468

1.54

1.70

10.6

6.2

1.9

e9/l

0.06

417

(3018010) Neutrophils/100 leukocytes in Blood

441

1.54

1.68

8.8

5.8

58.8

58.3

0.11

406

(40768804) Tissue Pathology biopsy report

392

0.59

1.67

2.0

2.2

—

(40758558) Short blood count panel - Blood

238

1.63

1.61

11.2

8.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.17

1.54

2.1

1.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.94

1.52

7.0

5.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

393

1.52

4.7

4.3

35.4

35.1

g/l

0.12

369

(3037467) Urinalysis macro (dipstick) panel - Urine

634

1.49

1.47

5.3

4.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

910

0.67

1.47

4.9

4.5

4.3

4.5

mmol/l

1.47

829

(3052851) Hemolysis interference index of Serum or Plasma

2.49

1.41

1.6

3.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

550

1.47

1.40

17.4

10.2

4.8

4.2

e9/l

0.92

472

(3009508) Creatinine [Moles/volume] in Urine

290

1.53

1.40

7.0

3.1

5.8

7.5

mmol/l

1.31

243

(3022217) INR in Platelet poor plasma by Coagulation assay

138

1.71

1.36

31.3

24.9

1.3

inr

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

903

0.69

1.34

5.0

4.4

1.3

1.4

mmol/l

2.28

817

(1761868) Lipid panel - Serum or Plasma

313

0.61

1.25

3.5

3.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.37

1.20

1.2

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.37

1.20

1.2

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

872

0.71

1.13

4.2

4.0

1.4

1.3

mmol/l

0.73

788

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

494

1.38

1.04

5.3

6.5

9.6

12.4

umol/l

1.12

472

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

2.32

1.04

1.8

1.4

—

(3000330) Specific gravity of Urine by Test strip

1.94

1.03

2.4

3.9

—

(3026782) Osmolality of Urine

193

1.50

1.00

3.3

3.1

445.5

538.7

mosm/kgh2o

1.04

163

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

931

0.73

1.00

5.3

5.0

2.5

2.7

mmol/l

1.25

842

(3020682) Albumin/Creatinine [Ratio] in Urine

291

1.42

1.00

4.3

4.1

8.6

7.8

mg/mmol

0.06

184

(3008898) HLA-B27 [Presence]

0.00

0.98

0.0

1.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

160

1.52

0.97

2.9

0.7

0.9

e6/l

0.31

(3021589) Normoblasts [#/volume] in Blood

406

1.36

0.93

12.8

10.4

0.0

e9/l

0.56

325

(3019060) Gas panel - Arterial blood

1.81

0.93

9.1

4.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

315

1.38

0.89

3.9

3.0

975.9

1787.0

ng/l

1.41

252

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

163

1.49

0.89

3.1

1.9

—

(3042936) Bacteria identified in Isolate by Culture

138

1.53

0.88

1.7

2.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.98

0.85

1.2

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.98

0.85

1.2

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.98

0.85

3.8

4.5

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.91

0.83

1.2

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

175

1.45

0.82

1.4

2.0

2.7

g/l

0.90

112

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.68

0.81

1.6

—

(40768793) Breast Pathology biopsy report

0.00

0.80

0.0

1.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.80

0.0

2.2

—

3.9

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.80

0.0

2.4

—

192.2

—

(3012516) Albumin [Mass/volume] in Urine

276

1.36

0.77

3.3

83.2

281.0

mg/l

0.40

178

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.22

0.77

1.2

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

117

1.52

0.76

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

371

1.32

0.74

2.9

2.4

68.1

77.5

nmol/l

2.15

331

(3044889) 12 lead EKG panel

633

1.29

0.73

4.0

3.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

119

1.49

0.71

3.1

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.70

0.69

4.3

2.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.88

0.69

2.0

1.3

—

(3000991) Gas panel - Venous blood

1.59

0.68

4.9

6.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

138

1.44

0.67

2.1

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.81

0.67

1.4

1.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.75

0.64

1.2

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

122

1.45

0.64

3.1

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.60

0.61

6.9

5.6

24.5

24.9

mmol/l

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.61

0.0

1.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

654

1.25

0.60

4.8

4.0

14.6

15.0

pmol/l

0.67

592

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.54

0.59

3.3

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

297

1.29

0.59

4.0

3.4

213.6

228.8

e6/l

0.02

234

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.59

0.0

1.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

179

1.34

0.56

3.3

2.7

2.5

mmol/l

0.12

151

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

108

1.44

0.56

8.7

7.6

—

(3022145) Colonoscopy Study observation

0.60

0.54

1.3

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.49

0.54

1.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

236

1.29

0.52

2.9

1.9

2.9

3.3

mg/l

0.50

210

(3041096) Erythrocytes [Presence] in Urine by Automated

255

1.28

0.52

2.9

3.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

369

1.24

0.51

4.9

4.2

32.9

36.9

ng/l

0.11

270

(3032080) INR in Blood by Coagulation assay

398

1.23

0.50

7.5

9.2

1.3

inr

0.07

115

(3044640) Blood type and Crossmatch panel - Blood

304

1.25

0.49

1.9

2.4

—

(3015736) pH of Urine

363

1.23

0.46

3.1

3.8

—

(3019225) pH of Specimen

1.43

0.46

7.8

3.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

366

0.80

0.45

4.2

5.2

1.6

2.8

ug/l

1.60

317

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

139

0.70

0.44

1.1

1.4

—

11.0

—

(3035350) Ketones [Presence] in Urine by Test strip

452

1.20

0.44

3.5

4.0

0.0

estimate

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.58

0.42

1.0

1.2

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.58

0.42

1.4

2.3

2.0

1.6

mg/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

384

0.82

0.42

3.0

2.5

94.0

119.2

ug/l

0.44

349

(3014007) Fractional oxyhemoglobin in Arterial blood

1.40

0.42

14.5

7.7

93.6

95.3

—

(3003694) ABO and Rh group [Type] in Blood

236

0.77

0.42

1.4

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

80.1

—

(4094501)

0.00

0.41

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

455

1.19

0.40

3.5

4.0

0.0

estimate

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.40

0.0

1.6

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.1

—

13.9

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.40

0.0

3.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.44

0.39

1.8

1.7

—

(3049717) Cytology report of Urine Cyto stain

1.40

0.38

1.4

2.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

981

0.84

0.38

26.4

17.4

75.7

79.8

umol/l

0.73

981

(3021601) Nitrite [Presence] in Urine by Test strip

449

1.18

0.36

4.6

5.4

0.0

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

210

1.23

0.36

3.0

3.9

—

(3010813) Leukocytes [#/volume] in Blood

1027

0.84

0.35

39.7

22.1

7.4

6.8

e9/l

2.11

987

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.35

0.35

2.3

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

100

1.33

0.35

1.3

1.6

—

(3026361) Erythrocytes [#/volume] in Blood

1026

0.85

0.34

39.0

22.1

4.4

4.5

e12/l

1.15

987

(3007461) Platelets [#/volume] in Blood

1025

0.85

0.33

39.3

22.1

254.7

245.6

e9/l

0.76

992

(3013707) Erythrocyte sedimentation rate by Westergren method

700

1.16

0.33

4.4

4.3

12.1

12.9

mm/h

0.15

633

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

110

0.71

0.30

1.8

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

272

1.18

0.29

4.2

3.3

0.2

0.4

e6/l

1.02

209

(36304419) Bacteria [Presence] in Urine

263

1.18

0.29

4.2

3.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.27

0.28

7.1

2.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.24

0.27

1.4

1.6

—

(3000492) Spirometry study

0.69

0.24

1.7

1.3

—

(40761511) CBC panel - Blood by Automated count

957

0.88

0.24

21.9

13.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

125

1.22

0.23

1.5

1.6

—

(40768797) Stomach Pathology biopsy report

125

1.22

0.23

1.0

1.3

—

(3020891) Body temperature

1.33

0.23

19.4

5.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

16.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.5

—

39.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

222

1.15

0.21

1.7

2.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(4306422)

0.00

0.21

0.0

1.3

—

(4268621)

0.00

0.20

0.0

2.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.20

0.0

5.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.23

0.20

1.3

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

349

1.12

0.20

4.9

3.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

528

1.10

0.18

2.9

3.1

—

(3000494) Fungus identified in Specimen by Culture

131

0.83

0.18

1.8

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

287

0.88

0.18

3.4

4.9

21.0

21.3

—

149

(3025941) Bacteria identified in Stool by Culture

1.15

0.16

1.6

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.15

0.15

4.2

3.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

893

1.09

0.15

5.6

4.8

6.5

6.0

mmol/l

1.59

802

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

833

1.09

0.14

6.1

4.5

2.0

1.9

mu/l

0.28

732

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.19

0.12

1.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

617

1.07

0.11

4.2

3.0

44.3

50.0

u/l

0.33

573

(3018095) Leukocytes [#/volume] in Urine

340

1.08

0.11

4.8

3.8

30.7

36.2

e6/l

0.12

246

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

362

1.07

0.09

3.7

4.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

418

0.94

0.08

4.7

4.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

256

0.92

0.08

2.5

3.0

323.1

7793.0

umol/l

1.57

217

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.04

0.08

5.7

3.1

1.9

1.4

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.10

0.08

1.0

1.6

—

(40761535) Cells panel - Urine sediment

1.08

0.07

4.6

3.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

197

1.08

0.06

12.7

6.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

874

0.96

0.05

22.3

13.9

80.2

79.0

ml/min/173m2

0.14

721

(3013512) EKG study

289

1.05

0.04

4.8

3.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

929

1.04

0.03

23.6

15.0

26.6

25.5

mg/l

0.13

739

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

141

1.07

0.03

1.4

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

107

0.93

0.02

1.7

1.9

118.0

146.7

ug/g

—

(3029937) Albumin [Presence] in Urine by Test strip

264

1.03

0.00

3.8

4.2

0.0

estimate

—

(3009542) Hematocrit [Volume Fraction] of Blood

815

1.02

0.00

27.9

15.2

38.0

39.5

0.55

591

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

864

0.99

0.00

8.6

6.0

43.7

40.5

mmol/mol

1.27

807

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.87

0.00

3.4

2.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.7

—

(3035880) pH of Pleural fluid

0.00

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

107.8

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.7

—

12.3

—

(3022621) pH of Urine by Test strip

1.02

0.00

1.8

2.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.9

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3004451) EKG impression Narrative

0.00

0.0

1.0

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

7.7

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(4281824)

0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.2

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.8

—

56.6

—

(4010399)

0.98

0.00

1.2

1.4

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

15.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.5

—

13.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.6

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.7

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.9

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.8

—

40.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(36660697) Celiac disease serology panel - Serum

0.93

0.00

1.7

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint F5_UNSORG and mortality.

Females

Parameter	HR [95% CI]	p-value
F5_UNSORG	3.123 [2.53, 3.86]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.371

During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 887 females with F5_UNSORG died.

Males

Parameter	HR [95% CI]	p-value
F5_UNSORG	3.978 [2.97, 5.33]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.012

During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 830 males with F5_UNSORG died.

Mortality risk

Mortality risk for people of age

years, who have F5_UNSORG.

N-year risk	Females	Males
1	0.285%	0.828%
5	1.639%	4.349%
10	4.299%	11.111%
15	9.38%	19.664%
20	14.909%	33.032%

Relationships between endpoints

↥

Index endpoint: F5_UNSORG – Unspecified organic or symptomatic mental disorder

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Unspecified organic or symptomatic mental disorder

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints