Hypertensive encephalopathy

I9_HYPERTENC

hypertensive encephalopathy: Encephalopathy resulting from hypertension.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I67.4 Hospital discharge: ICD-9 — 4372 Cause of death: ICD-10 — I67.4 Cause of death: ICD-9 — 4372 2 out of 7 registries used, show all original rules.	141
4. Check minimum number of events None	141
5. Include endpoints None	141
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: I67
Name in latin: Encephalopathia hypertensiva

NAME	I9_HYPERTENC
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I674
HD_ICD_9	4372
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I674
COD_ICD_9	4372
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypertensive encephalopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1060	561	482
Only index persons	823	460	363
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	67.18	71.76	61.86
Only index persons	66.77	72.24	59.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	70	69
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	70.93	71.14	70.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
141: Matched controls
1410

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I67.4

ICD-10 Finland

Hypertensive encephalopathy

+∞

172.6

128

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

171.7

37.8

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

221.8

34.4

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

8.5

29.6

AA1AD

NOMESCO Finland

CT of head and brain

4.1

15.4

247

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

166.5

14.8

I67.3

ICD-10 Finland

Progressive vascular leukoencephalopathy

59.7

14.1

G30.1

ICD-10 Finland

Alzheimer disease with late onset

5.2

13.8

4372A

ICD-9 Finland

Other and ill-defined cerebrovascular disease, Hypertensive encephalopathy

+∞

12.7

C08CA01

ATC

amlodipine; oral

3.4

11.2

465

XA800

NOMESCO Finland

Neuropsychological investigation

23.8

10.9

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

5.2

10.2

N06DX01

ATC

memantine; oral

4.0

9.6

I10

ICD-10 Finland

Essential (primary) hypertension

3.9

9.4

117

779

Z01.9

ICD-10 Finland

Special examination, unspecified

5.2

9.4

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

5.4

9.4

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

8.3

8.8

XF400

NOMESCO Finland

ECG with 12 standard connections

3.3

8.7

162

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

5.4

8.6

Z3226

NOMESCO Finland

Physiotherapist

3.2

8.4

171

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.1

8.2

193

TPH07

NOMESCO Finland

Cathetrisation of artery

3.8

8.2

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

2.9

8.2

248

205

Kela drug reimbursment

Chronic hypertension

2.8

8.0

325

Z2446

NOMESCO Finland

Social worker

5.0

7.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

7.7

515

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

14.4

7.5

R56.8

ICD-10 Finland

Other and unspecified convulsions

7.3

7.4

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

+∞

7.3

Z2221

NOMESCO Finland

Medical doctor

2.7

7.2

241

C03AA03

ATC

hydrochlorothiazide; oral

3.6

7.1

ZXD10

NOMESCO Finland

Scheduled procedure

2.6

7.1

373

R5110, ,

SPAT

4.6

6.8

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.0

6.7

140

C07AB07

ATC

bisoprolol; oral

2.6

6.6

644

TKC20

NOMESCO Finland

Catheterisation of bladder

4.1

6.4

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

10.0

6.4

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

+∞

6.3

4019X

ICD-9 Finland

Essential hypertension, Unspecified

6.6

6.2

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.8

6.1

166

R41.3

ICD-10 Finland

Other amnesia

5.9

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

468

4.16

14.75

2.9

2.1

95.59

95.49

pmol/l

0.01

232

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

232

3.35

10.56

4.0

3.2

2.48

2.47

mmol/l

0.44

195

(3015377) Calcium [Moles/volume] in Serum or Plasma

396

2.99

9.40

3.6

2.36

2.34

mmol/l

0.49

343

(3024561) Albumin [Mass/volume] in Serum or Plasma

514

2.81

8.12

10.7

4.4

34.51

34.63

g/l

0.08

476

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

547

2.70

7.44

9.6

5.4

1.20

1.21

mmol/l

0.66

495

(3018418) pH of Serum or Plasma

379

2.46

6.39

6.2

3.8

7.39

7.40

—

(3019309) Folate [Moles/volume] in Red Blood Cells

263

2.55

6.29

1.9

1.8

858.22

1238.98

nmol/l

2.66

193

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

599

2.39

5.75

13.6

5.9

1.21

mmol/l

0.25

499

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

309

2.35

5.47

2.9

2.1

3.54

3.31

mg/l

0.24

258

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

8.41

5.45

1.5

1.7

—

(3001604) Monocytes [#/volume] in Blood

516

2.21

5.03

8.6

5.3

0.63

0.60

e9/l

0.33

458

(3006315) Basophils [#/volume] in Blood

517

2.20

5.00

8.6

5.3

0.04

e9/l

0.18

458

(3037467) Urinalysis macro (dipstick) panel - Urine

103

751

2.38

5.00

6.3

4.8

—

(3019198) Lymphocytes [#/volume] in Blood

528

2.19

4.93

8.6

5.4

1.60

1.70

e9/l

0.65

477

(3014111) Lactate [Moles/volume] in Serum or Plasma

110

2.80

4.91

6.4

1.42

1.29

mmol/l

0.15

105

(3023368) Bacteria identified in Blood by Culture

355

2.20

4.85

4.8

4.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.44

4.66

2.7

2.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

111

858

2.38

4.36

10.8

7.4

87.86

80.13

u/l

0.45

104

792

(3013115) Eosinophils [#/volume] in Blood

536

2.08

4.34

9.0

5.5

0.18

0.19

e9/l

0.20

477

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

7.31

4.23

1.7

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

487

2.03

4.14

10.6

6.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.78

4.05

1.7

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

613

2.03

4.01

10.7

8.9

4.13

4.27

e9/l

0.27

535

(3011397) Hemoglobin [Presence] in Urine by Test strip

238

2.16

4.00

3.2

4.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.98

3.93

2.1

1.5

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

329

2.04

3.89

2.1

1.9

212.31

254.85

u/l

0.22

301

(3000850) Epithelial cells [#/volume] in Urine

272

2.09

3.88

2.8

5.78

5.11

e6/l

0.13

250

(36304419) Bacteria [Presence] in Urine

339

2.02

3.82

4.6

3.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

196

2.20

3.82

4.5

2.8

2.38

3.18

e6/l

0.22

106

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

5.93

3.72

1.2

1.6

—

nmol/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

119

975

2.41

3.65

5.7

4.7

1.78

1.97

mu/l

1.27

111

861

(3026008) Bacteria identified in Urine by Culture

387

1.96

3.63

3.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.04

3.63

1.1

1.0

—

(1761868) Lipid panel - Serum or Plasma

337

0.35

3.62

3.6

3.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

8.11

3.60

1.4

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

10.37

3.53

1.7

2.2

—

(3030467) Casts [#/volume] in Urine by Automated count

357

1.94

3.48

4.7

3.1

0.11

0.44

e6/l

2.89

269

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.76

3.45

1.5

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

204

2.10

3.43

4.5

2.7

0.77

1.12

e6/l

0.64

113

(3022217) INR in Platelet poor plasma by Coagulation assay

586

1.90

3.40

32.9

17.1

1.40

1.35

inr

—

176

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

7.29

3.40

1.4

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

7.29

3.40

1.4

1.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

449

1.88

3.34

4.9

3.2

—

(3012516) Albumin [Mass/volume] in Urine

344

1.92

3.34

4.5

3.2

1281.73

239.79

mg/l

0.41

217

(3018095) Leukocytes [#/volume] in Urine

441

1.88

3.31

5.7

3.8

23.87

105.28

e6/l

2.43

323

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

8.88

3.29

1.5

2.0

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.54

3.26

10.6

2.8

114.83

79.90

ng/l

0.91

(46235355) HIV 1 and 2 tests - Meaningful Use set

120

2.32

3.23

2.3

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

366

1.88

3.17

4.9

3.7

25.72

8.25

mg/mmol

1.08

223

(3002582) Erythrocytes [#/volume] in Urine

395

1.85

3.08

4.5

3.3

58.37

48.21

e6/l

0.17

306

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

7.77

3.08

1.3

1.1

1.80

1.88

mmol/l

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

10.30

3.00

2.0

1.8

—

(3044290) Cell count panel - Cerebral spinal fluid

4.92

2.96

1.5

1.4

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

4.29

2.93

3.8

2.6

3.20

3.11

g/l

—

(3023520) Reticulocytes [#/volume] in Blood

111

2.28

2.93

2.0

3.5

66.91

69.10

e9/l

0.11

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

4.64

2.84

2.4

2.9

248.13

190.50

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.40

2.78

2.6

2.4

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

8.58

2.77

2.6

2.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.20

2.76

1.4

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

354

1.80

2.73

4.3

3.1

7.14

7.29

mmol/l

0.08

288

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

136

2.12

2.73

9.4

6.8

4.68

5.03

kpa

0.98

130

(3027801) Oxygen [Partial pressure] in Arterial blood

136

2.12

2.73

9.3

6.8

10.77

11.36

kpa

0.33

131

(3045788) Cell count panel - Pleural fluid

6.21

2.72

1.3

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

205

1.94

2.71

2.3

1.8

—

(3042936) Bacteria identified in Isolate by Culture

175

1.99

2.66

1.9

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

7.35

2.57

1.4

1.3

352.00

330.00

pmol/l

—

(21491868) Cryoglobulin [Mass/volume] in Serum

7.35

2.57

1.0

—

(3026782) Osmolality of Urine

268

1.81

2.49

3.2

3.0

525.70

525.94

mosm/kgh2o

0.00

235

(3026493) Urate [Moles/volume] in Serum or Plasma

303

1.77

2.45

3.2

2.7

384.11

6529.74

umol/l

1.77

258

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

6.43

2.39

1.6

1.1

—

(3000991) Gas panel - Venous blood

100

2.17

2.35

12.1

7.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

559

1.63

2.16

2.4

2.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.15

2.11

2.9

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.03

2.11

1.3

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.63

2.06

1.7

1.8

—

(40758558) Short blood count panel - Blood

274

1.70

2.04

8.1

6.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.37

1.97

16.2

8.3

—

(3044889) 12 lead EKG panel

788

1.63

1.95

5.0

4.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

4.28

1.84

1.2

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.15

1.82

1.6

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

615

1.56

1.80

8.5

6.0

16.99

11.73

umol/l

0.96

583

(40761511) CBC panel - Blood by Automated count

123

1102

1.91

1.80

25.0

15.9

—

(3021589) Normoblasts [#/volume] in Blood

482

1.56

1.78

13.8

11.1

0.00

0.01

e9/l

0.51

408

(3002256) Pathology report gross observation

135

1.84

1.76

1.3

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

329

0.54

1.76

5.6

4.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

120

1072

1.80

1.71

28.4

16.3

25.38

25.84

mg/l

0.05

103

878

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.61

1.70

1.9

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

124

1119

1.90

1.70

33.7

19.5

98.23

82.10

umol/l

1.94

124

1119

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

631

1.53

1.68

4.1

3.0

87.14

51.20

u/l

0.62

582

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.55

1.68

1.1

1.4

—

(3012441) Differential panel - Pleural fluid

3.66

1.63

1.4

1.2

—

(3024928) Oxygen saturation in Venous blood

2.59

1.62

4.6

2.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.59

1.62

1.4

5.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

343

1.56

1.61

3.5

2.7

31.40

33.81

u/l

0.26

322

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

257

1.60

1.56

2.1

1.7

0.96

1.46

mg/l

1.14

210

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

439

0.62

1.51

4.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.02

1.50

9.5

6.7

26.01

24.89

mmol/l

0.82

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.58

1.47

1.6

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

263

1.55

1.41

2.5

2.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

118

1066

1.66

1.39

6.1

5.2

2.24

2.64

mmol/l

5.03

113

950

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

113

1011

1.59

1.38

28.4

15.9

65.16

74.35

ml/min/173m2

3.58

847

(3044941) Cell count panel - Synovial fluid

3.01

1.37

1.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

113

1015

1.57

1.32

8.2

6.3

40.73

40.87

mmol/mol

0.05

106

923

(3019832) Treponema pallidum Ab [Presence] in Serum

2.43

1.31

1.3

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.46

1.25

1.8

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.46

1.25

1.8

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

142

1.65

1.23

2.7

1.8

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

103

1.74

1.19

1.4

2.0

443.94

386.54

nmol/l

0.76

(40761536) Microorganisms panel - Urine sediment

110

0.43

1.19

9.4

4.7

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

1.18

0.0

1.3

—

0.08

—

(3009542) Hematocrit [Volume Fraction] of Blood

125

1159

1.69

1.16

42.4

23.9

38.52

39.55

1.14

118

1076

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.55

1.16

1.2

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

104

1.72

1.15

2.9

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

775

1.40

1.12

4.7

3.9

15.36

15.07

pmol/l

0.45

690

(3029937) Albumin [Presence] in Urine by Test strip

313

0.65

1.06

4.1

4.6

0.00

estimate

—

112

(40768797) Stomach Pathology biopsy report

166

1.54

1.03

1.4

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

141

1.57

1.02

2.8

1.8

—

(3049717) Cytology report of Urine Cyto stain

1.89

1.01

2.3

2.6

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.99

0.0

2.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.19

0.92

1.3

1.6

—

(3022313) Gas panel - Capillary blood

1.96

0.90

4.9

2.9

—

(3019225) pH of Specimen

104

1.61

0.89

7.7

3.6

—

(40768443) Skin Pathology biopsy report

1.82

0.86

1.1

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

131

1.52

0.84

1.7

1.6

—

(3000492) Spirometry study

1.62

0.81

1.5

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

167

1.45

0.80

9.3

6.1

104.91

103.81

mmol/l

0.57

167

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

230

1.39

0.78

3.7

3.1

0.62

0.77

ug/l

1.13

150

(3000494) Fungus identified in Specimen by Culture

125

1.50

0.77

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

111

1030

1.37

0.76

6.3

4.9

6.26

6.07

mmol/l

0.64

103

914

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.84

0.73

1.4

1.6

—

(3000475) Leukocytes [#/volume] in Synovial fluid

2.04

0.73

1.0

1.6

8772.00

14602.28

e6/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

554

1.28

0.73

6.6

6.0

0.00

estimate

—

113

(3044640) Blood type and Crossmatch panel - Blood

372

1.31

0.72

2.8

2.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

420

1.30

0.71

3.8

3.1

3860.55

1623.32

ng/l

0.99

354

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.96

0.71

1.4

2.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.96

0.71

1.8

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.96

0.71

1.4

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

129

1.45

0.67

12.6

8.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.53

0.67

2.2

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

551

1.26

0.64

4.1

4.4

0.00

estimate

—

121

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.75

0.64

1.2

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.60

0.64

12.2

9.3

0.62

0.74

0.37

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.69

0.62

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.69

0.62

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.69

0.62

1.2

1.5

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.69

0.62

1.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.57

0.61

12.2

8.8

1.05

1.64

1.46

(3048689) Calprotectin [Mass/mass] in Stool

114

0.59

0.61

3.6

2.1

143.33

157.37

ug/g

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.8

—

(40761535) Cells panel - Urine sediment

1.51

0.56

2.8

4.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.56

0.56

2.4

3.0

4.03

4.25

pmol/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.60

0.55

1.7

2.1

—

(4200892) Spirometry reversibility

1.43

0.52

1.7

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.52

0.52

1.8

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.52

0.52

1.8

—

(3009261) Glucose [Presence] in Urine by Test strip

563

1.22

0.50

4.1

4.4

0.00

estimate

—

113

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

108

1021

1.25

0.48

5.1

4.7

1.36

1.47

mmol/l

2.15

907

(40768804) Tissue Pathology biopsy report

439

1.22

0.47

1.8

2.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

109

1032

1.25

0.47

5.1

4.7

4.08

4.53

mmol/l

4.07

101

928

(3009343) pH of Capillary blood

1.46

0.43

4.4

2.8

—

7.41

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

141

1.32

0.43

3.2

4.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.41

0.0

2.5

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

3.9

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.41

0.0

1.2

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.3

—

21.60

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.44

0.39

1.2

2.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

321

1.21

0.39

4.2

4.3

22.76

22.74

0.00

161

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.37

1.8

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.29

0.37

4.2

2.3

0.73

0.69

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

156

0.75

0.37

1.1

1.3

—

9.20

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.40

0.35

4.3

2.3

1.45

1.36

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

511

1.16

0.33

5.4

4.1

181.10

53.12

ng/l

0.39

382

(3013512) EKG study

375

0.84

0.33

5.6

4.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

984

1.17

0.32

4.5

4.1

1.26

1.23

mmol/l

0.23

867

(3007164) IgA [Mass/volume] in Serum or Plasma

190

1.19

0.25

1.6

2.21

2.84

g/l

0.69

107

(3052851) Hemolysis interference index of Serum or Plasma

1.36

0.24

2.4

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.33

0.23

1.2

2.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

2.9

—

76.34

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

3.6

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.5

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

113

0.78

0.21

7.3

4.8

1.21

1.23

mmol/l

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.20

0.0

2.9

—

667.50

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.24

0.20

1.8

1.5

—

(3003694) ABO and Rh group [Type] in Blood

278

0.88

0.19

1.5

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.17

2.3

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

130

1.17

0.16

1.3

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

119

0.83

0.16

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

511

1.09

0.16

2.9

2.6

—

(3022145) Colonoscopy Study observation

126

0.86

0.12

1.2

—

(3019060) Gas panel - Arterial blood

1.16

0.09

10.2

3.9

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.14

0.09

1.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

0.81

0.08

1.3

—

(4035726) Immunohistochemistry procedure

116

1.04

0.00

1.3

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

169

1.01

0.00

1.2

1.3

23.43

40.61

iu/ml

—

(36660697) Celiac disease serology panel - Serum

0.93

0.00

1.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.95

0.00

1.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.86

0.00

1.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

7.0

—

235.83

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

75.14

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

6.51

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

76.45

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.0

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

-0.00

0.0

1.2

—

67.00

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.8

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

7.09

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

30.06

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

18.16

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.6

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

5.6

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

686.75

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

-0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.1

—

57.43

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_HYPERTENC and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_HYPERTENC	1.734 [1.28, 2.34]	< 0.001
Birth year	0.994 [0.98, 1.0]	0.144

During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 379 females with I9_HYPERTENC died.

Males

Parameter	HR [95% CI]	p-value
I9_HYPERTENC	1.693 [1.05, 2.72]	0.03
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 273 males with I9_HYPERTENC died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPERTENC.

N-year risk	Females	Males
1	0.233%	0.273%
5	1.208%	1.923%
10	2.592%	4.794%
15	4.882%	8.678%
20	8.622%	14.586%

Relationships between endpoints

↥

Index endpoint: I9_HYPERTENC – Hypertensive encephalopathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypertensive encephalopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints