hypertensive encephalopathy: Encephalopathy resulting from hypertension.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
125 |
4. Check minimum number of eventsNone |
125 |
5. Include endpointsNone |
125 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Encephalopathia hypertensiva
Similar endpoints
↥List of similar endpoints to
Hypertensive encephalopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Hypertension
- Hypertensive diseases (excluding secondary)
- Hypertensive diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1060 | 561 | 482 |
| Only index persons | 823 | 460 | 363 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 67.18 | 71.76 | 61.86 |
| Only index persons | 66.77 | 72.24 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 65 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 69.14 | 68.82 | 69.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 114
- Matched controls
- 1140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.4
ICD-10 Finland
Hypertensive encephalopathy
+∞
134.5
101
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
+∞
31.8
29
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
142.5
22.5
23
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
13.8
13
*
4372A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Hypertensive encephalopathy
+∞
12.7
12
*
I10
ICD-10 Finland
Essential (primary) hypertension
5.5
12.6
96
563
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.0
12.3
32
60
C08CA01
ATC
amlodipine; oral
4.1
11.8
70
316
AA1AD
NOMESCO Finland
CT of head and brain
4.2
10.7
49
172
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
54.3
8.8
10
*
XA800
NOMESCO Finland
Neuropsychological investigation
22.1
8.7
12
6
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.3
8.3
15
15
C07AB07
ATC
bisoprolol; oral
3.2
8.2
76
435
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.1
8.0
19
31
R56.8
ICD-10 Finland
Other and unspecified convulsions
8.7
7.7
16
21
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
7.4
7
*
205
Kela drug reimbursment
Chronic hypertension
3.1
7.2
55
266
TAB00
NOMESCO Finland
Lumbar puncture
10.3
7.0
13
14
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
6.7
33
118
Z01.9
ICD-10 Finland
Special examination, unspecified
6.5
6.1
15
26
R4110
NOMESCO Finland
Physiotherapy
3.0
6.1
41
179
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
83
409
4.06
12.84
2.8
2.1
pmol/l
97.0
96.5
0.03
52
202
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
49
209
3.21
8.75
4.1
3.1
mmol/l
2.5
2.5
0.60
44
178
(3015377) Calcium [Moles/volume] in Serum or Plasma
66
361
2.75
7.20
3.6
3.4
mmol/l
2.4
2.3
0.59
59
311
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
79
477
2.78
7.04
9.4
5.3
mmol/l
1.2
1.2
0.22
71
430
(3024561) Albumin [Mass/volume] in Serum or Plasma
76
454
2.72
6.85
11.3
4.2
g/l
34.5
34.6
0.04
71
418
(42870588) Differential panel, method unspecified - Blood
60
320
2.68
6.78
7.0
4.9
—
—
—
0
0
(3012544) pH of Venous blood
29
107
3.23
6.40
8.0
2.7
—
—
—
0
0
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
18
48
4.21
6.35
6.7
2.6
mmol/l
23.1
24.0
0.63
18
42
(3019309) Folate [Moles/volume] in Red Blood Cells
47
232
2.64
6.09
1.8
1.8
nmol/l
839.1
1277.0
3.29
33
172
(3014111) Lactate [Moles/volume] in Serum or Plasma
24
88
3.14
5.31
5.3
7.2
mmol/l
1.1
1.2
0.69
24
82
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
80
529
2.42
5.29
13.9
5.6
mmol/l
1.2
1.2
0.02
67
439
(3026250) Tacrolimus [Mass/volume] in Blood
5
0
+∞
5.24
40.0
0.0
ug/l
8.4
—
—
5
0
(3001604) Monocytes [#/volume] in Blood
71
452
2.32
5.04
7.5
5.3
e9/l
0.6
0.6
0.45
56
399
(3006315) Basophils [#/volume] in Blood
71
454
2.31
4.96
7.5
5.3
e9/l
0.0
0.0
0.20
56
402
(3018418) pH of Serum or Plasma
57
339
2.25
4.66
6.9
3.8
ph
7.4
7.4
—
6
77
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
9
11
8.71
4.64
1.7
1.1
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
71
463
2.23
4.62
7.6
5.3
e9/l
1.6
1.7
0.74
57
412
(3011397) Hemoglobin [Presence] in Urine by Test strip
40
206
2.38
4.56
3.4
4.3
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
71
468
2.20
4.44
7.9
5.5
e9/l
0.2
0.2
0.42
57
417
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
48
274
2.22
4.27
2.7
2.1
mg/l
3.6
3.3
0.31
42
231
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
9
13
7.36
4.24
1.4
1.8
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
9
13
7.36
4.24
1.7
1.2
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
33
162
2.41
4.15
4.5
2.8
e6/l
2.6
3.0
0.08
17
89
(3037467) Urinalysis macro (dipstick) panel - Urine
90
663
2.28
4.14
6.5
4.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
17
59
3.18
4.08
2.1
1.6
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
7
7
10.49
4.06
1.4
1.0
—
—
—
0
0
(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma
20
77
2.90
4.04
10.6
2.4
ng/l
114.8
77.9
0.98
20
67
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
15
49
3.34
3.96
2.5
2.4
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
15
49
3.34
3.96
2.5
2.4
g/l
3.7
3.7
—
10
33
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
15
49
3.34
3.96
2.5
2.4
g/l
7.4
7.7
—
10
35
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
6
5
12.50
3.80
1.5
1.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
54
336
2.07
3.76
3.4
3.4
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
7
9
8.15
3.60
1.4
1.0
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
7
9
8.15
3.60
1.4
1.0
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
33
172
2.25
3.58
4.5
2.7
e6/l
0.8
1.2
0.72
18
98
(3013650) Neutrophils [#/volume] in Blood by Automated count
75
533
2.02
3.55
10.2
9.3
e9/l
4.1
4.3
0.51
64
469
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
17
65
2.87
3.47
1.5
1.4
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
9
18
5.30
3.44
1.1
1.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
64
435
1.97
3.39
12.4
10.9
inr
1.4
1.3
—
6
141
(1761868) Lipid panel - Serum or Plasma
12
299
0.34
3.39
3.8
3.3
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
50
313
2.00
3.35
5.2
4.0
mg/mmol
28.0
8.9
1.07
38
190
(46235355) HIV 1 and 2 tests - Meaningful Use set
23
105
2.46
3.34
2.4
1.6
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
48
297
2.00
3.32
4.7
3.2
mg/l
1426.4
274.3
0.40
35
187
(3023368) Bacteria identified in Blood by Culture
51
324
1.97
3.26
4.9
4.3
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
7
11
6.66
3.23
1.4
1.0
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
95
752
2.10
3.13
10.8
7.4
u/l
87.5
80.3
0.34
88
694
(3023520) Reticulocytes [#/volume] in Blood
21
96
2.43
3.04
2.0
3.0
e9/l
68.9
66.1
0.14
12
76
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
104
856
2.28
3.04
5.8
4.8
mu/l
1.8
2.0
0.88
96
760
(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture
5
5
10.34
3.00
2.6
2.0
—
—
—
0
0
(3000991) Gas panel - Venous blood
19
84
2.49
2.95
10.6
8.0
—
—
—
0
0
(3014218) Bicarbonate [Moles/volume] standard in Arterial blood
13
47
2.97
2.92
6.8
11.7
mmol/l
24.7
25.1
0.17
13
41
(3045788) Cell count panel - Pleural fluid
6
9
6.93
2.90
1.3
1.2
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
47
301
1.90
2.87
4.7
3.1
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
5
6
8.61
2.77
1.6
1.0
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
5
6
8.61
2.77
1.4
1.0
mmol/l
1.8
1.9
—
5
6
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
58
401
1.83
2.77
5.0
3.2
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
7
14
5.23
2.77
1.6
1.1
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
40
246
1.92
2.74
2.8
2.8
e6/l
6.6
5.2
0.24
31
222
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
8
19
4.42
2.73
4.0
2.6
g/l
3.2
3.4
—
8
19
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
47
307
1.85
2.67
2.1
1.9
u/l
180.5
260.2
0.54
47
281
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
7
15
4.87
2.63
1.1
1.7
nmol/l
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
17
76
2.43
2.58
2.5
2.5
—
—
—
0
0
(21491868) Cryoglobulin [Mass/volume] in Serum
5
7
7.38
2.57
1.0
1.0
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
7
16
4.57
2.51
2.4
3.0
%
238.9
203.3
—
7
16
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
32
188
1.94
2.49
2.4
1.8
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
47
314
1.80
2.45
4.8
3.1
e6/l
0.1
0.5
3.06
37
239
(3009542) Hematocrit [Volume Fraction] of Blood
96
793
1.91
2.40
34.6
17.3
%
37.1
39.2
1.34
67
498
(3018095) Leukocytes [#/volume] in Urine
55
387
1.75
2.39
6.1
3.7
e6/l
18.3
106.8
2.44
39
288
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
9
28
3.38
2.36
1.3
1.1
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
11
41
2.85
2.34
1.7
1.7
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
27
153
1.98
2.32
2.0
1.9
—
—
—
0
0
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
23
123
2.07
2.30
7.0
6.8
kpa
4.6
5.0
1.10
23
117
(3027801) Oxygen [Partial pressure] in Arterial blood
23
123
2.07
2.30
7.0
6.8
kpa
10.4
11.3
0.51
23
118
(3002582) Erythrocytes [#/volume] in Urine
50
347
1.73
2.26
4.6
3.2
e6/l
67.5
48.3
0.31
38
272
(3026493) Urate [Moles/volume] in Serum or Plasma
40
264
1.76
2.14
3.3
2.7
umol/l
381.7
7495.2
1.78
32
223
(3012441) Differential panel - Pleural fluid
5
10
5.16
2.09
1.4
1.2
—
—
—
0
0
(3026782) Osmolality of Urine
36
232
1.77
2.08
3.1
2.8
mosm/kgh2o
512.7
532.9
0.26
27
201
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
10
38
2.77
2.06
1.9
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
7
21
3.47
1.99
1.6
1.1
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
34
223
1.72
1.83
2.1
1.7
mg/l
0.9
1.5
1.64
26
181
(3009445) Proteinase 3 Ab [Units/volume] in Serum
9
36
2.61
1.78
1.1
1.5
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
57
431
1.59
1.76
12.3
11.1
e9/l
0.0
0.0
0.51
39
364
(3024928) Oxygen saturation in Venous blood
7
24
3.03
1.75
4.1
2.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
16
83
2.06
1.74
3.1
1.4
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
34
227
1.68
1.71
2.4
2.1
—
—
—
0
0
(40758558) Short blood count panel - Blood
35
242
1.62
1.53
7.8
6.3
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
63
501
1.52
1.49
2.6
2.8
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
105
938
1.75
1.47
28.8
16.4
mg/l
25.8
26.2
0.04
92
774
(3041096) Erythrocytes [Presence] in Urine by Automated
18
287
0.56
1.43
5.4
4.3
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
7
29
2.50
1.41
1.4
6.1
—
—
—
0
0
(3019225) pH of Specimen
16
90
1.89
1.41
7.7
3.2
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
11
54
2.14
1.37
11.4
7.9
—
—
—
0
0
(3036481) Cortisol [Moles/volume] in Serum or Plasma
16
92
1.85
1.32
1.3
2.1
nmol/l
455.3
367.6
1.56
16
83
(3024891) Influenza virus A+B Ag [Presence] in Specimen
6
24
2.57
1.32
1.7
1.1
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
108
982
1.73
1.29
34.3
19.5
umol/l
99.6
81.7
1.88
108
982
(3022313) Gas panel - Capillary blood
8
36
2.30
1.27
4.9
2.5
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
107
972
1.70
1.26
26.0
15.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
28
388
0.64
1.24
4.7
4.8
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
12
64
1.97
1.23
7.4
7.1
mmol/l
25.9
25.0
0.51
12
64
(3044889) 12 lead EKG panel
81
696
1.47
1.21
5.0
4.2
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
67
556
1.44
1.20
4.3
2.9
u/l
89.1
53.0
0.51
61
509
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
99
888
1.55
1.17
8.4
6.3
mmol/mol
41.1
40.7
0.15
92
809
(3002256) Pathology report gross observation
18
113
1.69
1.13
1.3
1.3
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
98
881
1.52
1.11
28.2
16.2
ml/min/173m2
64.7
74.3
3.26
80
737
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
5
21
2.44
1.10
2.0
1.1
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
5
21
2.44
1.10
2.0
1.1
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
7
32
2.26
1.10
1.3
1.7
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
59
487
1.40
1.05
6.7
6.0
estimate
0.0
0.0
—
6
107
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
15
92
1.72
1.02
3.1
1.3
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
58
480
1.39
1.01
4.0
4.3
estimate
0.0
0.0
—
6
109
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
9
50
1.86
0.99
2.4
2.4
pmol/l
4.0
4.3
—
9
41
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
30
0.00
0.98
0.0
1.3
—
0.1
—
0
9
(40768797) Stomach Pathology biopsy report
21
143
1.56
0.98
1.4
1.2
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
41
321
1.41
0.98
2.7
2.2
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
18
118
1.61
0.97
12.6
8.7
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
79
692
1.38
0.95
4.6
4.0
pmol/l
15.4
15.1
0.36
72
615
(3007853) Bacteria identified in Skin by Aerobe culture
18
119
1.60
0.94
1.7
1.6
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
5
102
0.47
0.94
1.6
2.1
ug/g
120.3
165.9
—
5
81
(3000494) Fungus identified in Specimen by Culture
16
103
1.63
0.93
1.4
1.3
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
12
71
1.76
0.92
8.9
2.5
g/l
117.8
128.3
1.17
12
71
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
19
129
1.56
0.90
2.9
1.9
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
102
939
1.47
0.88
6.1
5.2
mmol/l
2.2
2.6
4.07
97
841
(3000492) Spirometry study
12
73
1.71
0.85
1.6
1.3
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
58
493
1.33
0.81
4.1
4.5
estimate
0.0
0.0
—
6
106
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
45
369
1.34
0.79
3.7
3.2
ng/l
4216.3
1635.9
1.02
37
312
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
5
23
2.22
0.77
1.4
1.8
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
5
23
2.22
0.77
1.4
1.8
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
5
23
2.22
0.77
1.8
1.0
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
5
25
2.04
0.73
1.2
1.5
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
5
25
2.04
0.73
1.2
1.4
—
—
—
0
0
(40768443) Skin Pathology biopsy report
7
40
1.79
0.72
1.0
1.2
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
9
58
1.59
0.71
10.9
2.6
mmol/l
24.5
24.9
—
9
58
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
5
26
1.96
0.71
1.2
1.3
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
18
128
1.47
0.70
3.1
1.8
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
98
910
1.36
0.67
6.1
4.9
mmol/l
6.3
6.0
0.79
90
811
(3009343) pH of Capillary blood
10
63
1.64
0.64
4.4
2.5
—
7.4
—
0
14
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
20
0.00
0.61
0.0
1.8
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
52
450
1.27
0.60
5.3
4.2
ng/l
192.1
54.1
0.39
40
338
(4010399)
8
54
1.51
0.58
1.8
1.4
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
6
36
1.70
0.57
1.8
1.7
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
9
60
1.54
0.56
4.2
2.2
%
1.3
1.5
—
9
60
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
96
901
1.28
0.51
5.2
4.7
mmol/l
1.4
1.5
1.94
87
802
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
10
67
1.54
0.51
9.4
9.4
%
0.6
0.7
—
10
67
(40761535) Cells panel - Urine sediment
11
76
1.49
0.50
2.8
4.3
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
12
85
1.46
0.49
2.4
1.4
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
7
47
1.52
0.48
2.1
2.7
—
—
—
0
0
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
10
69
1.49
0.46
9.4
8.9
%
1.0
1.7
—
10
69
(3052851) Hemolysis interference index of Serum or Plasma
5
32
1.59
0.42
2.6
2.1
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
32
1.59
0.42
1.6
2.0
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
33
1.54
0.42
1.2
2.0
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
5
33
1.54
0.42
2.0
1.4
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
11
148
0.72
0.41
1.1
1.2
—
9.0
—
0
55
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
124
1.33
0.41
3.3
4.1
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
18
0.00
0.40
0.0
2.4
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
1.3
—
21.6
—
0
18
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
96
911
1.23
0.40
5.3
4.7
mmol/l
4.1
4.5
3.04
88
821
(40760892) CBC W Ordered Manual Differential panel - Blood
16
201
0.77
0.39
9.9
5.7
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
50
448
1.19
0.39
3.8
4.0
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
36
1.40
0.38
1.2
2.2
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
31
266
1.22
0.37
3.8
4.4
%
20.7
23.0
0.37
15
145
(3020961) Endomysium IgA Ab [Titer] in Serum
6
46
1.32
0.33
1.0
1.1
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
91
866
1.19
0.32
4.7
4.1
mmol/l
1.3
1.2
0.43
81
764
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
9
118
0.74
0.29
1.3
1.3
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
64
1.27
0.28
1.9
1.3
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
8
104
0.75
0.22
7.5
5.0
mmol/l
1.2
1.2
—
8
92
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
10
80
1.27
0.21
1.9
1.6
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
13
0.00
0.21
0.0
4.1
—
66.7
—
0
13
(3005570) Glucose [Moles/volume] in Urine
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
14
0.00
0.20
0.0
2.8
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
1.4
—
2.9
—
0
14
(3013139) Helicobacter pylori Ag [Presence] in Stool
6
51
1.19
0.19
1.0
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
68
0.72
0.17
1.0
1.2
—
—
—
0
0
(3019060) Gas panel - Arterial blood
9
80
1.13
0.15
7.6
3.5
—
—
—
0
0
(4035726)
12
103
1.18
0.14
1.3
1.4
—
—
—
0
0
(3013512) EKG study
31
328
0.93
0.09
5.8
4.1
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
6
53
1.14
0.09
2.5
2.4
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
13
120
1.09
0.05
1.3
1.5
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
40
390
1.04
0.03
1.7
2.2
—
—
—
0
0
(3022145) Colonoscopy Study observation
10
108
0.92
0.03
1.1
1.2
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
16
156
1.03
0.00
1.2
1.2
iu/ml
23.4
48.8
—
7
53
(3003694) ABO and Rh group [Type] in Blood
24
237
1.02
0.00
1.5
1.3
—
—
—
0
0
(3026470) Cobalt [Mass/volume] in Blood
0
6
0.00
0.00
0.0
2.8
—
5.6
—
0
6
(3028707) Methadone [Presence] in Urine by Screen method
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
6
0.00
0.00
0.0
1.2
—
6.5
—
0
6
(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
59
1.02
0.00
1.3
1.2
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3020717) Zinc [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
11.6
—
0
5
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
8.2
—
237.6
—
0
5
(3007164) IgA [Mass/volume] in Serum or Plasma
17
170
1.00
0.00
1.6
1.6
g/l
2.5
2.8
—
9
96
(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
18.2
—
0
5
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
7
0.00
0.00
0.0
5.1
—
—
—
0
0
(3037556) Urate [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(4146454)
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
751.7
—
0
7
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
8
0.00
0.00
0.0
3.3
—
2143.8
—
0
8
(44806420)
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
7.1
—
0
7
(40768441) Liver Pathology biopsy report
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010838) Calcium [Moles/time] in 24 hour Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid
0
5
0.00
0.00
0.0
1.2
—
67.0
—
0
5
(3002619) Bacteria identified in Specimen by Culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
12.0
—
0
5
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPERTENC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.734 [1.28, 2.34] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 379 females with I9_HYPERTENC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPERTENC | 1.693 [1.05, 2.72] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 273 males with I9_HYPERTENC died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPERTENC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.273% |
| 5 | 1.208% | 1.923% |
| 10 | 2.592% | 4.794% |
| 15 | 4.882% | 8.678% |
| 20 | 8.622% | 14.586% |
Relationships between endpoints
↥Index endpoint: I9_HYPERTENC – Hypertensive encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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