Hypertensive encephalopathy

I9_HYPERTENC

hypertensive encephalopathy: Encephalopathy resulting from hypertension.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I67.4 Hospital discharge: ICD-9 — 4372 Cause of death: ICD-10 — I67.4 Cause of death: ICD-9 — 4372 2 out of 7 registries used, show all original rules.	125
4. Check minimum number of events None	125
5. Include endpoints None	125
6. Filter based on genotype QC (FinnGen only)	125

Control definitions (FinnGen only)

Control exclude: I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: I67
Name in latin: Encephalopathia hypertensiva

NAME	I9_HYPERTENC
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I674
HD_ICD_9	4372
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I674
COD_ICD_9	4372
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypertensive encephalopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1060	561	482
Only index persons	823	460	363
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	67.18	71.76	61.86
Only index persons	66.77	72.24	59.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	125	65	60
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	69.14	68.82	69.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
114: Matched controls
1140

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I67.4

ICD-10 Finland

Hypertensive encephalopathy

+∞

134.5

101

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

+∞

31.8

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

142.5

22.5

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

+∞

13.8

4372A

ICD-9 Finland

Other and ill-defined cerebrovascular disease, Hypertensive encephalopathy

+∞

12.7

I10

ICD-10 Finland

Essential (primary) hypertension

5.5

12.6

563

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

7.0

12.3

C08CA01

ATC

amlodipine; oral

4.1

11.8

316

AA1AD

NOMESCO Finland

CT of head and brain

4.2

10.7

172

I67.3

ICD-10 Finland

Progressive vascular leukoencephalopathy

54.3

8.8

XA800

NOMESCO Finland

Neuropsychological investigation

22.1

8.7

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

11.3

8.3

C07AB07

ATC

bisoprolol; oral

3.2

8.2

435

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.1

8.0

R56.8

ICD-10 Finland

Other and unspecified convulsions

8.7

7.7

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

+∞

7.4

205

Kela drug reimbursment

Chronic hypertension

3.1

7.2

266

TAB00

NOMESCO Finland

Lumbar puncture

10.3

7.0

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.5

6.7

118

Z01.9

ICD-10 Finland

Special examination, unspecified

6.5

6.1

R4110

NOMESCO Finland

Physiotherapy

3.0

6.1

179

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

409

4.06

12.84

2.8

2.1

97.0

96.5

pmol/l

0.03

202

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

209

3.21

8.75

4.1

3.1

2.5

mmol/l

0.60

178

(3015377) Calcium [Moles/volume] in Serum or Plasma

361

2.75

7.20

3.6

3.4

2.4

2.3

mmol/l

0.59

311

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

477

2.78

7.04

9.4

5.3

1.2

mmol/l

0.22

430

(3024561) Albumin [Mass/volume] in Serum or Plasma

454

2.72

6.85

11.3

4.2

34.5

34.6

g/l

0.04

418

(42870588) Differential panel, method unspecified - Blood

320

2.68

6.78

7.0

4.9

—

(3012544) pH of Venous blood

107

3.23

6.40

8.0

2.7

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

4.21

6.35

6.7

2.6

23.1

24.0

mmol/l

0.63

(3019309) Folate [Moles/volume] in Red Blood Cells

232

2.64

6.09

1.8

839.1

1277.0

nmol/l

3.29

172

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.14

5.31

5.3

7.2

1.1

1.2

mmol/l

0.69

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

529

2.42

5.29

13.9

5.6

1.2

mmol/l

0.02

439

(3026250) Tacrolimus [Mass/volume] in Blood

+∞

5.24

40.0

0.0

8.4

—

ug/l

—

(3001604) Monocytes [#/volume] in Blood

452

2.32

5.04

7.5

5.3

0.6

e9/l

0.45

399

(3006315) Basophils [#/volume] in Blood

454

2.31

4.96

7.5

5.3

0.0

e9/l

0.20

402

(3018418) pH of Serum or Plasma

339

2.25

4.66

6.9

3.8

7.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

8.71

4.64

1.7

1.1

—

(3019198) Lymphocytes [#/volume] in Blood

463

2.23

4.62

7.6

5.3

1.6

1.7

e9/l

0.74

412

(3011397) Hemoglobin [Presence] in Urine by Test strip

206

2.38

4.56

3.4

4.3

—

(3013115) Eosinophils [#/volume] in Blood

468

2.20

4.44

7.9

5.5

0.2

e9/l

0.42

417

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

274

2.22

4.27

2.7

2.1

3.6

3.3

mg/l

0.31

231

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

7.36

4.24

1.4

1.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

7.36

4.24

1.7

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

162

2.41

4.15

4.5

2.8

2.6

3.0

e6/l

0.08

(3037467) Urinalysis macro (dipstick) panel - Urine

663

2.28

4.14

6.5

4.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.18

4.08

2.1

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

10.49

4.06

1.4

1.0

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.90

4.04

10.6

2.4

114.8

77.9

ng/l

0.98

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

3.96

2.5

2.4

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

3.96

2.5

2.4

3.7

g/l

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.34

3.96

2.5

2.4

7.4

7.7

g/l

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

12.50

3.80

1.5

1.0

—

(3026008) Bacteria identified in Urine by Culture

336

2.07

3.76

3.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

8.15

3.60

1.4

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

8.15

3.60

1.4

1.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

172

2.25

3.58

4.5

2.7

0.8

1.2

e6/l

0.72

(3013650) Neutrophils [#/volume] in Blood by Automated count

533

2.02

3.55

10.2

9.3

4.1

4.3

e9/l

0.51

469

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.87

3.47

1.5

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.30

3.44

1.1

—

(3032080) INR in Blood by Coagulation assay

435

1.97

3.39

12.4

10.9

1.4

1.3

inr

—

141

(1761868) Lipid panel - Serum or Plasma

299

0.34

3.39

3.8

3.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

313

2.00

3.35

5.2

4.0

28.0

8.9

mg/mmol

1.07

190

(46235355) HIV 1 and 2 tests - Meaningful Use set

105

2.46

3.34

2.4

1.6

—

(3012516) Albumin [Mass/volume] in Urine

297

2.00

3.32

4.7

3.2

1426.4

274.3

mg/l

0.40

187

(3023368) Bacteria identified in Blood by Culture

324

1.97

3.26

4.9

4.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.66

3.23

1.4

1.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

752

2.10

3.13

10.8

7.4

87.5

80.3

u/l

0.34

694

(3023520) Reticulocytes [#/volume] in Blood

2.43

3.04

2.0

3.0

68.9

66.1

e9/l

0.14

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

104

856

2.28

3.04

5.8

4.8

1.8

2.0

mu/l

0.88

760

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

10.34

3.00

2.6

2.0

—

(3000991) Gas panel - Venous blood

2.49

2.95

10.6

8.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.97

2.92

6.8

11.7

24.7

25.1

mmol/l

0.17

(3045788) Cell count panel - Pleural fluid

6.93

2.90

1.3

1.2

—

(36304419) Bacteria [Presence] in Urine

301

1.90

2.87

4.7

3.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

8.61

2.77

1.6

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

8.61

2.77

1.4

1.0

1.8

1.9

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

401

1.83

2.77

5.0

3.2

—

(3044290) Cell count panel - Cerebral spinal fluid

5.23

2.77

1.6

1.1

—

(3000850) Epithelial cells [#/volume] in Urine

246

1.92

2.74

2.8

6.6

5.2

e6/l

0.24

222

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

4.42

2.73

4.0

2.6

3.2

3.4

g/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

307

1.85

2.67

2.1

1.9

180.5

260.2

u/l

0.54

281

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

4.87

2.63

1.1

1.7

—

nmol/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.43

2.58

2.5

—

(21491868) Cryoglobulin [Mass/volume] in Serum

7.38

2.57

1.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

4.57

2.51

2.4

3.0

238.9

203.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

188

1.94

2.49

2.4

1.8

—

(3030467) Casts [#/volume] in Urine by Automated count

314

1.80

2.45

4.8

3.1

0.1

0.5

e6/l

3.06

239

(3009542) Hematocrit [Volume Fraction] of Blood

793

1.91

2.40

34.6

17.3

37.1

39.2

1.34

498

(3018095) Leukocytes [#/volume] in Urine

387

1.75

2.39

6.1

3.7

18.3

106.8

e6/l

2.44

288

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.38

2.36

1.3

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.85

2.34

1.7

—

(3042936) Bacteria identified in Isolate by Culture

153

1.98

2.32

2.0

1.9

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

123

2.07

2.30

7.0

6.8

4.6

5.0

kpa

1.10

117

(3027801) Oxygen [Partial pressure] in Arterial blood

123

2.07

2.30

7.0

6.8

10.4

11.3

kpa

0.51

118

(3002582) Erythrocytes [#/volume] in Urine

347

1.73

2.26

4.6

3.2

67.5

48.3

e6/l

0.31

272

(3026493) Urate [Moles/volume] in Serum or Plasma

264

1.76

2.14

3.3

2.7

381.7

7495.2

umol/l

1.78

223

(3012441) Differential panel - Pleural fluid

5.16

2.09

1.4

1.2

—

(3026782) Osmolality of Urine

232

1.77

2.08

3.1

2.8

512.7

532.9

mosm/kgh2o

0.26

201

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.77

2.06

1.9

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.47

1.99

1.6

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

223

1.72

1.83

2.1

1.7

0.9

1.5

mg/l

1.64

181

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.61

1.78

1.1

1.5

—

(3021589) Normoblasts [#/volume] in Blood

431

1.59

1.76

12.3

11.1

0.0

e9/l

0.51

364

(3024928) Oxygen saturation in Venous blood

3.03

1.75

4.1

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.06

1.74

3.1

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

227

1.68

1.71

2.4

2.1

—

(40758558) Short blood count panel - Blood

242

1.62

1.53

7.8

6.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

501

1.52

1.49

2.6

2.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

105

938

1.75

1.47

28.8

16.4

25.8

26.2

mg/l

0.04

774

(3041096) Erythrocytes [Presence] in Urine by Automated

287

0.56

1.43

5.4

4.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.50

1.41

1.4

6.1

—

(3019225) pH of Specimen

1.89

1.41

7.7

3.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.14

1.37

11.4

7.9

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.85

1.32

1.3

2.1

455.3

367.6

nmol/l

1.56

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.57

1.32

1.7

1.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

108

982

1.73

1.29

34.3

19.5

99.6

81.7

umol/l

1.88

108

982

(3022313) Gas panel - Capillary blood

2.30

1.27

4.9

2.5

—

(40761511) CBC panel - Blood by Automated count

107

972

1.70

1.26

26.0

15.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

388

0.64

1.24

4.7

4.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.97

1.23

7.4

7.1

25.9

25.0

mmol/l

0.51

(3044889) 12 lead EKG panel

696

1.47

1.21

5.0

4.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

556

1.44

1.20

4.3

2.9

89.1

53.0

u/l

0.51

509

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

888

1.55

1.17

8.4

6.3

41.1

40.7

mmol/mol

0.15

809

(3002256) Pathology report gross observation

113

1.69

1.13

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

881

1.52

1.11

28.2

16.2

64.7

74.3

ml/min/173m2

3.26

737

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.44

1.10

2.0

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.44

1.10

2.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.26

1.10

1.3

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

487

1.40

1.05

6.7

6.0

0.0

estimate

—

107

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.72

1.02

3.1

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

480

1.39

1.01

4.0

4.3

0.0

estimate

—

109

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.86

0.99

2.4

4.0

4.3

pmol/l

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.98

0.0

1.3

—

0.1

—

(40768797) Stomach Pathology biopsy report

143

1.56

0.98

1.4

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

321

1.41

0.98

2.7

2.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

118

1.61

0.97

12.6

8.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

692

1.38

0.95

4.6

4.0

15.4

15.1

pmol/l

0.36

615

(3007853) Bacteria identified in Skin by Aerobe culture

119

1.60

0.94

1.7

1.6

—

(3048689) Calprotectin [Mass/mass] in Stool

102

0.47

0.94

1.6

2.1

120.3

165.9

ug/g

—

(3000494) Fungus identified in Specimen by Culture

103

1.63

0.93

1.4

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.76

0.92

8.9

2.5

117.8

128.3

g/l

1.17

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

129

1.56

0.90

2.9

1.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

102

939

1.47

0.88

6.1

5.2

2.2

2.6

mmol/l

4.07

841

(3000492) Spirometry study

1.71

0.85

1.6

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

493

1.33

0.81

4.1

4.5

0.0

estimate

—

106

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

369

1.34

0.79

3.7

3.2

4216.3

1635.9

ng/l

1.02

312

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.22

0.77

1.4

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.22

0.77

1.4

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.22

0.77

1.8

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.04

0.73

1.2

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.04

0.73

1.2

1.4

—

(40768443) Skin Pathology biopsy report

1.79

0.72

1.0

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.59

0.71

10.9

2.6

24.5

24.9

mmol/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.96

0.71

1.2

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

128

1.47

0.70

3.1

1.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

910

1.36

0.67

6.1

4.9

6.3

6.0

mmol/l

0.79

811

(3009343) pH of Capillary blood

1.64

0.64

4.4

2.5

—

7.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

450

1.27

0.60

5.3

4.2

192.1

54.1

ng/l

0.39

338

(4010399)

1.51

0.58

1.8

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.70

0.57

1.8

1.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.54

0.56

4.2

2.2

1.3

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

901

1.28

0.51

5.2

4.7

1.4

1.5

mmol/l

1.94

802

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.54

0.51

9.4

0.6

0.7

—

(40761535) Cells panel - Urine sediment

1.49

0.50

2.8

4.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.46

0.49

2.4

1.4

—

(3049717) Cytology report of Urine Cyto stain

1.52

0.48

2.1

2.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.49

0.46

9.4

8.9

1.0

1.7

—

(3052851) Hemolysis interference index of Serum or Plasma

1.59

0.42

2.6

2.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.59

0.42

1.6

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.54

0.42

1.2

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.54

0.42

2.0

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

148

0.72

0.41

1.1

1.2

—

9.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.41

0.0

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

124

1.33

0.41

3.3

4.1

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.40

0.0

2.4

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.3

—

21.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

911

1.23

0.40

5.3

4.7

4.1

4.5

mmol/l

3.04

821

(40760892) CBC W Ordered Manual Differential panel - Blood

201

0.77

0.39

9.9

5.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

448

1.19

0.39

3.8

4.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.40

0.38

1.2

2.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

266

1.22

0.37

3.8

4.4

20.7

23.0

0.37

145

(3020961) Endomysium IgA Ab [Titer] in Serum

1.32

0.33

1.0

1.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

866

1.19

0.32

4.7

4.1

1.3

1.2

mmol/l

0.43

764

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

118

0.74

0.29

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.27

0.28

1.9

1.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

104

0.75

0.22

7.5

5.0

1.2

mmol/l

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.27

0.21

1.9

1.6

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.5

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.1

—

66.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.20

0.0

2.6

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.20

0.0

2.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.20

0.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

2.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.19

0.19

1.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.72

0.17

1.0

1.2

—

(3019060) Gas panel - Arterial blood

1.13

0.15

7.6

3.5

—

(4035726)

103

1.18

0.14

1.3

1.4

—

(3013512) EKG study

328

0.93

0.09

5.8

4.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.09

2.5

2.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

120

1.09

0.05

1.3

1.5

—

(40768804) Tissue Pathology biopsy report

390

1.04

0.03

1.7

2.2

—

(3022145) Colonoscopy Study observation

108

0.92

0.03

1.1

1.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

156

1.03

0.00

1.2

23.4

48.8

iu/ml

—

(3003694) ABO and Rh group [Type] in Blood

237

1.02

0.00

1.5

1.3

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.8

—

5.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

6.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.02

0.00

1.3

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

11.6

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

8.2

—

237.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

170

1.00

0.00

1.6

2.5

2.8

g/l

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.4

—

18.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

5.1

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(4146454)

0.00

0.0

3.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

751.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(3012565) Volume of 24 hour Urine

0.00

0.0

3.3

—

2143.8

—

(44806420)

0.00

0.0

2.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

7.1

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.2

—

67.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

12.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_HYPERTENC and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_HYPERTENC	1.734 [1.28, 2.34]	< 0.001
Birth year	0.994 [0.98, 1.0]	0.144

During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 379 females with I9_HYPERTENC died.

Males

Parameter	HR [95% CI]	p-value
I9_HYPERTENC	1.693 [1.05, 2.72]	0.03
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 273 males with I9_HYPERTENC died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPERTENC.

N-year risk	Females	Males
1	0.233%	0.273%
5	1.208%	1.923%
10	2.592%	4.794%
15	4.882%	8.678%
20	8.622%	14.586%

Relationships between endpoints

↥

Index endpoint: I9_HYPERTENC – Hypertensive encephalopathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypertensive encephalopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints