≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Onychogryphosis

DOID Endpoint Browser PheWeb

L12_NAIL_GRYPHOSIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L60.2
  • Hospital discharge: ICD-9 — 7038C
  • Hospital discharge: ICD-8 — 70305
  • Cause of death: ICD-10 — L60.2
  • Cause of death: ICD-9 — 7038C
  • Cause of death: ICD-8 — 70305

2 out of 7 registries used, show all original rules.

93

4. Check minimum number of events

None

93

5. Include endpoints

None

93

6. Filter based on genotype QC (FinnGen only)

90

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60
Name in latin
Onychogryposis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1009 654 347
Only index persons 760 483 277
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 55.13 56.57 52.13
Only index persons 52.59 53.62 50.79

-FinnGen-

Key figures

All Female Male
Number of individuals 90 59 31
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 50.75 51.08 50.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.2
ICD-10 Finland
Onychogryphosis
2686.4
87.8
71
*
70305
ICD-8 Finland
Diseases of nail, Onychogryphosis
+∞
17.2
16
*
QDH00
NOMESCO Finland
Avulsion of toe nail
73.4
16.4
18
*
B35.1
ICD-10 Finland
Tinea unguium
7.0
11.6
20
35
L84
ICD-10 Finland
Corns and callosities
15.7
10.7
17
13
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.6
7.9
22
59
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
49.3
7.9
9
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.8
7.6
14
15
SPAT1229
SPAT
Assessment of need for aid
7.2
7.5
18
30
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.8
7.2
18
44
L03.0
ICD-10 Finland
Cellulitis of finger and toe
4.9
6.9
17
41
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
24.6
6.8
9
*
D01BA02
ATC
terbinafine; oral
3.3
6.7
35
144
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
6.6
20
57
N30.0
ICD-10 Finland
Acute cystitis
3.9
6.6
23
73
V03AE01
ATC
polystyrene sulfonate; oral
28.8
6.3
8
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
28.8
6.3
8
*
7038C
ICD-9 Finland
Diseases of nail, Other specified diseases of nail[ONYCHOGRYPHOSIS]
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
88
3.71
6.77
3.7
1.6
—
—
—
0
0
53
292
2.90
5.94
2.0
1.8
89.57
98.57
pmol/l
0.71
28
143
21
70
3.58
5.52
13.0
4.5
—
—
—
0
0
21
76
3.28
4.84
1.6
1.5
—
—
—
0
0
43
232
2.59
4.75
2.9
2.2
—
—
—
0
0
13
27
5.42
4.71
5.1
3.9
23.77
24.90
mmol/l
0.53
13
27
37
187
2.63
4.66
4.5
4.3
—
—
—
0
0
56
346
2.55
4.61
21.2
14.7
1.27
1.18
inr
0.25
15
99
22
87
3.00
4.36
2.4
1.7
—
—
—
0
0
14
35
4.52
4.32
10.0
3.8
—
—
—
0
0
16
53
3.44
4.20
3.6
2.4
5.42
4.40
kpa
0.63
16
53
17
60
3.24
4.05
4.5
3.2
5.70
5.75
kpa
0.08
17
60
53
333
2.38
4.03
8.4
5.4
3.15
2.87
%
0.57
48
311
21
85
2.90
3.98
16.5
4.1
1.10
1.03
mmol/l
0.56
21
75
33
169
2.48
3.95
2.5
2.0
3.40
3.30
mg/l
0.09
33
143
53
338
2.32
3.83
9.0
5.8
8.58
8.48
%
0.08
48
316
18
68
3.04
3.83
2.7
1.5
—
—
—
0
0
41
235
2.33
3.80
4.4
4.0
—
—
—
0
0
16
58
3.12
3.64
2.8
1.6
—
—
—
0
0
53
344
2.26
3.60
8.8
5.7
24.29
28.11
%
1.64
46
323
51
326
2.25
3.60
8.7
5.3
0.80
0.72
%
0.53
46
301
32
168
2.38
3.59
1.8
1.8
439.25
473.84
pmol/l
0.26
24
140
68
493
2.41
3.51
5.9
4.3
—
5444.45
—
0
11
33
178
2.32
3.46
1.5
1.5
18.97
22.75
nmol/l
0.93
25
145
23
106
2.55
3.38
5.0
2.2
11.27
14.72
umol/l
1.67
23
99
52
341
2.19
3.38
8.1
5.5
60.17
56.96
%
1.20
46
322
39
231
2.19
3.24
4.5
2.7
6.13
7.43
mmol/l
1.21
29
191
37
215
2.20
3.22
4.6
3.0
1723.55
68.88
mg/l
0.50
25
124
51
337
2.14
3.19
10.0
5.9
—
—
—
0
0
38
227
2.14
3.06
6.1
3.5
19.03
11.34
mg/mmol
0.25
21
130
15
58
2.89
3.05
4.7
3.5
—
—
—
0
0
61
438
2.14
3.00
7.0
4.4
7.09
6.65
mmol/l
0.68
56
409
19
85
2.55
2.95
1.2
1.2
—
—
—
0
0
59
422
2.09
2.89
9.5
9.4
3.74
3.98
e9/l
0.62
52
359
52
361
2.00
2.70
16.0
5.7
1.20
1.22
mmol/l
0.84
44
306
66
499
2.11
2.70
6.8
4.3
—
—
—
0
0
45
297
2.00
2.70
4.8
4.0
88.31
47.54
ng/l
0.47
29
210
22
110
2.31
2.69
4.1
1.9
—
—
—
0
0
13
50
2.86
2.66
14.4
7.4
—
—
—
0
0
9
25
3.87
2.65
1.3
1.2
—
—
—
0
0
9
25
3.87
2.65
2.0
2.8
—
—
—
0
0
52
365
1.96
2.58
8.6
5.6
0.20
0.19
e9/l
0.12
44
319
26
142
2.15
2.57
2.2
1.8
1152.45
1280.75
nmol/l
0.30
20
112
10
35
3.08
2.29
1.2
1.5
—
—
—
0
0
5
9
5.79
2.24
1.6
1.6
—
—
—
0
0
49
352
1.83
2.14
8.7
5.3
0.04
0.04
e9/l
0.03
43
299
49
353
1.82
2.11
8.7
5.2
0.57
0.57
e9/l
0.07
43
299
22
122
2.05
2.07
2.5
2.8
0.83
0.81
mmol/l
0.31
22
113
44
309
1.80
2.04
2.0
2.0
—
—
—
0
0
84
740
2.39
1.90
6.1
4.5
6.39
5.97
mmol/l
0.76
75
681
29
183
1.85
1.88
3.8
2.8
401.83
7687.48
umol/l
1.31
24
155
49
362
1.75
1.87
8.8
5.3
1.59
1.78
e9/l
0.87
43
319
30
195
1.79
1.76
4.7
2.5
0.76
0.25
e6/l
0.51
19
140
34
232
1.73
1.68
3.7
2.9
—
—
—
0
0
10
42
2.54
1.68
1.2
1.5
—
—
—
0
0
8
32
2.64
1.64
2.0
1.8
—
—
—
0
0
6
21
2.98
1.53
1.8
3.9
—
—
—
0
0
24
152
1.78
1.51
1.9
1.7
0.93
1.09
mg/l
0.17
19
121
15
81
2.02
1.50
9.1
5.9
4.91
5.04
kpa
0.22
15
76
86
780
2.36
1.48
24.9
13.3
—
—
—
0
0
13
68
2.06
1.41
3.1
3.1
2.11
1.81
%
0.34
13
57
29
198
1.68
1.40
4.9
2.5
—
—
—
0
0
81
719
1.98
1.39
8.8
5.5
41.99
40.49
mmol/mol
0.64
72
673
23
154
1.66
1.18
4.7
3.8
—
—
—
0
0
8
39
2.15
1.18
1.4
1.3
—
—
—
0
0
7
30
2.44
1.15
17.7
8.7
23.81
24.04
mmol/l
—
7
30
30
218
1.56
1.11
4.7
2.8
31.61
347.39
e6/l
0.53
18
164
83
756
1.91
1.11
27.5
13.7
24.00
22.47
mg/l
0.19
72
583
7
32
2.28
1.11
21.0
5.7
24.61
24.55
mmol/l
—
7
32
5
21
2.46
1.10
3.2
1.8
—
—
—
0
0
11
60
1.95
1.08
1.4
1.5
—
—
—
0
0
9
47
2.01
1.06
14.3
7.0
0.73
0.71
%
—
9
47
67
582
1.54
1.04
4.6
4.1
14.96
14.86
pmol/l
0.10
58
525
9
48
1.97
1.04
14.3
7.0
1.37
1.71
%
—
9
48
65
562
1.52
1.03
6.1
3.9
16.52
11.96
mm/h
1.56
56
510
10
54
1.95
1.01
1.1
1.4
—
—
—
0
0
83
762
1.83
0.99
5.9
5.0
2.72
2.76
mmol/l
0.13
74
699
33
251
1.49
0.98
5.7
3.3
21.71
74.93
e6/l
1.45
19
171
88
829
2.14
0.96
37.1
20.4
252.55
250.74
e9/l
0.09
88
804
43
347
1.44
0.94
4.8
3.7
0.00
0.00
estimate
—
9
69
8
42
1.99
0.91
2.9
2.5
122.38
127.52
g/l
—
8
42
26
191
1.50
0.90
4.3
3.9
0.00
0.00
estimate
—
9
63
13
81
1.70
0.86
10.4
5.9
94.63
95.53
%
0.18
13
76
13
81
1.70
0.86
12.4
6.2
105.69
103.91
mmol/l
0.75
13
81
26
193
1.48
0.86
1.6
1.3
—
—
—
0
0
10
58
1.81
0.83
6.2
3.9
—
—
—
0
0
88
830
2.12
0.83
37.1
20.4
4.30
4.47
e12/l
2.43
88
802
88
830
2.12
0.83
36.9
20.3
92.66
91.29
fl
1.85
88
817
88
830
2.12
0.83
36.9
20.3
30.57
30.36
pg
0.53
88
817
88
830
2.12
0.83
38.5
20.4
39.21
40.10
%
1.04
83
785
43
354
1.40
0.82
5.0
3.7
0.33
0.00
estimate
—
9
61
6
33
1.87
0.80
2.0
2.4
—
—
—
0
0
78
716
1.55
0.78
5.6
4.7
1.77
1.96
mu/l
0.74
69
653
9
53
1.77
0.78
1.4
3.8
—
—
—
0
0
34
271
1.40
0.77
3.5
3.1
2.39
2.36
mmol/l
0.56
29
237
7
39
1.86
0.74
1.4
1.6
1.47
1.18
g/l
—
7
33
42
349
1.37
0.74
7.2
4.9
0.00
0.00
estimate
—
9
67
7
40
1.81
0.73
3.1
2.4
0.71
0.64
%
—
7
40
7
41
1.76
0.72
3.1
2.4
0.89
1.16
%
—
7
41
5
29
1.76
0.65
1.8
3.2
3.54
3.82
mmol/l
—
5
29
22
169
1.40
0.60
4.3
7.1
—
—
—
0
0
6
37
1.66
0.57
20.5
7.4
—
—
—
0
0
76
715
1.34
0.45
5.2
4.0
1.39
1.28
mmol/l
0.79
67
652
5
33
1.54
0.42
3.8
3.7
—
—
—
0
0
5
33
1.54
0.42
2.4
2.8
23.30
25.20
mmol/l
—
5
33
79
751
1.34
0.40
5.7
4.5
4.59
4.71
mmol/l
0.49
70
699
0
18
0.00
0.40
0.0
2.4
—
15.39
—
0
18
24
200
1.27
0.39
4.0
3.1
—
—
—
0
0
19
155
1.28
0.36
4.8
3.9
1.01
1.02
kg/l
—
5
22
12
93
1.33
0.32
1.2
1.2
—
—
—
0
0
61
647
0.83
0.30
23.2
16.5
15.15
15.52
%
0.19
61
637
8
64
1.27
0.28
8.0
3.8
1.24
1.22
mmol/l
—
8
55
9
72
1.28
0.26
1.4
1.2
—
—
—
0
0
16
133
1.25
0.26
1.3
1.3
12.55
25.95
iu/ml
—
8
50
18
152
1.23
0.26
1.5
1.4
2.47
2.74
g/l
0.26
13
87
12
147
0.79
0.25
1.8
3.3
2.49
2.45
mmol/l
1.03
12
131
5
37
1.37
0.24
1.6
3.4
—
—
—
0
0
17
145
1.21
0.22
3.3
2.6
511.92
529.23
mosm/kgh2o
0.13
12
123
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
3.91
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
77
745
1.20
0.20
5.8
4.4
1.43
1.52
mmol/l
0.84
68
686
13
111
1.20
0.17
1.5
1.3
—
—
—
0
0
5
45
1.12
0.10
2.4
1.4
—
—
—
0
0
5
63
0.78
0.08
1.4
1.1
—
—
—
0
0
26
275
0.92
0.08
2.8
3.0
—
—
—
0
0
14
129
1.10
0.06
1.1
1.3
0.94
14.27
u/ml
—
5
44
52
526
0.97
0.00
4.0
3.7
—
—
—
0
0
22
222
0.99
0.00
6.7
3.6
7.40
7.40
ph
—
8
43
32
315
1.02
0.00
16.5
9.9
0.00
0.00
e9/l
0.71
26
245
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
54
0.92
0.00
3.6
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
33.12
—
0
8
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.90
-0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
0.50
—
0
9
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.3
—
31.90
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
6.70
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
209.17
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint L12_NAIL_GRYPHOSIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_NAIL_GRYPHOSIS 1.729 [1.08, 2.77] 0.023
Birth year 0.996 [0.99, 1.0] 0.325

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 308 females with L12_NAIL_GRYPHOSIS died.

Males

Parameter HR [95% CI] p-value
L12_NAIL_GRYPHOSIS 1.993 [1.26, 3.15] 0.003
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 199 males with L12_NAIL_GRYPHOSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAIL_GRYPHOSIS.

N-year risk Females Males
1 0.15% 0.353%
5 0.942% 2.183%
10 2.462% 5.526%
15 4.902% 10.297%
20 8.73% 16.677%

Relationships between endpoints

↥

Index endpoint: L12_NAIL_GRYPHOSIS – Onychogryphosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data