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Thrombotic microangiopathy

DOID EFO Endpoint Browser PheWeb

M13_HTROMBMICROANG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.1
  • Hospital discharge: ICD-9 — 4466
  • Hospital discharge: ICD-8 — 4464
  • Cause of death: ICD-10 — M31.1
  • Cause of death: ICD-9 — 4466
  • Cause of death: ICD-8 — 4464

2 out of 7 registries used, show all original rules.

225

4. Check minimum number of events

None

225

5. Include endpoints

None

225

6. Filter based on genotype QC (FinnGen only)

216

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Microangiopathia thrombotica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1214 706 498
Only index persons 1034 606 428
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 56.61 55.13 58.60
Only index persons 55.82 54.53 57.64

-FinnGen-

Key figures

All Female Male
Number of individuals 216 128 88
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 54.29 52.08 57.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
225
Matched controls
2250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
232.6
181
*
L04AX01
ATC
azathioprine; systemic
100.5
214.0
117
24
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
28.4
150.1
138
119
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
108.3
95
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
13.6
61.9
67
68
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
61.3
56
*
L04AA06
ATC
mycophenolic acid; systemic
100.7
61.0
65
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
12.5
58.3
67
74
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
57.8
53
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
29.3
56.1
39
16
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
17.6
55.4
49
35
M05BA04
ATC
alendronic acid; oral
10.7
53.4
69
89
L04AX03
ATC
methotrexate; systemic
10.5
51.9
68
89
ZX120
NOMESCO Finland
Intravenous
9.5
51.5
75
112
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.4
48.9
51
48
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.5
48.8
153
499
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
46.5
43
*
L01BA01
ATC
methotrexate; systemic
19.1
44.5
37
23
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
19.3
43.6
36
22
H02AB06
ATC
prednisolone; systemic
6.7
38.2
170
711
L01AA01
ATC
cyclophosphamide; systemic
435.5
38.2
37
*
WW400
NOMESCO Finland
Plasmaferesis
+∞
36.4
34
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.5
35.2
72
151
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
34.8
162
686
H02AB07
ATC
prednisone; oral
6.4
34.7
72
153
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.2
34.0
46
61
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.2
34.0
46
61
P01BA02
ATC
hydroxychloroquine; oral
8.3
33.9
51
77
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
9.8
33.7
43
53
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
85.1
33.0
36
5
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.2
32.0
48
72
GD1AD
NOMESCO Finland
Thorax CT examination
9.7
31.4
40
49
H02AB04
ATC
methylprednisolone; systemic
5.7
30.5
73
175
TPH04
NOMESCO Finland
Cathetrisation of vein
4.8
28.6
93
287
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.1
28.3
32
33
R50.9
ICD-10 Finland
Fever, unspecified
5.3
27.6
72
185
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.4
25.9
98
336
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
39.6
25.0
31
9
TDM10
NOMESCO Finland
Puncture of maxillary antrum
10.0
24.8
30
34
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
24.4
23
*
TK800
NOMESCO Finland
Hemodialysis
24.6
22.9
32
15
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
242.6
22.0
22
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.9
21.8
32
46
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.1
21.2
41
79
Z2446
NOMESCO Finland
Social worker
6.5
21.2
38
68
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
20.8
47
105
C08CA05
ATC
nifedipine; systemic
6.7
20.3
35
60
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
20.3
69
214
A11CC03
ATC
alfacalcidol; systemic
16.8
20.1
32
22
Z94.0
ICD-10 Finland
Kidney transplant status
34.9
19.7
25
8
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.3
19.7
45
101
Z49.1
ICD-10 Finland
Extracorporeal dialysis
38.1
19.3
24
7
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.3
19.0
35
64
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
19.0
18
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
19.0
18
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
19.0
18
*
B03XA02
ATC
darbepoetin alfa; parenteral
21.7
18.7
27
14
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.4
18.2
25
33
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
17.9
17
*
L04AD01
ATC
ciclosporin; systemic
31.8
17.8
23
8
ZX108
NOMESCO Finland
Inhalation
194.7
17.8
18
*
1XC02, ,
NOMESCO Finland
54.5
17.3
20
*
A12AA04
ATC
calcium carbonate; oral
24.2
17.3
24
11
N18.0
ICD-10 Finland
End-stage renal disease
38.4
17.0
21
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.5
17.0
48
128
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
16.9
16
*
WX892
NOMESCO Finland
Monitored bed care
5.6
16.5
34
69
127
Kela drug reimbursment
Transplant complication
20.5
16.4
24
13
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
64.9
16.0
18
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
64.9
16.0
18
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
15.8
15
*
C03CA01
ATC
furosemide; systemic
3.2
15.7
94
413
XG410
NOMESCO Finland
Flow-volume spirometry
7.1
15.2
24
37
J01MA12
ATC
levofloxacin; systemic
3.5
15.2
69
255
L04AD02
ATC
tacrolimus; systemic
27.3
15.0
20
8
KA1AE
NOMESCO Finland
Kidney ultrasound examination
13.9
14.8
25
20
V03AE02
ATC
sevelamer; oral
85.8
14.8
16
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
14.7
14
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
29.4
14.5
19
7
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.0
14.5
47
138
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.0
14.4
23
36
N18.8
ICD-10 Finland
Other chronic renal failure
14.0
14.3
24
19
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
32.4
14.1
18
6
L04AA01
ATC
[U] ciclosporin
32.4
14.1
18
6
J01MA14
ATC
moxifloxacin; systemic
4.4
14.0
39
102
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
13.7
13
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
148.6
13.6
14
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
22.9
13.6
19
9
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
30.5
13.2
17
6
C09AA02
ATC
enalapril; systemic
3.1
12.7
67
269
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
12.6
12
*
JN4AD
NOMESCO Finland
Body CT examination
4.2
12.1
35
94
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.9
12.0
40
119
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.2
12.0
26
55
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.4
11.9
32
81
RS221, ,
NOMESCO Finland
17.7
11.9
18
11
C08CA02
ATC
felodipine; oral
4.1
11.8
35
96
J01MA02
ATC
ciprofloxacin; systemic
2.7
11.8
112
610
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
68.6
11.7
13
*
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
68.6
11.7
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
11.7
85
404
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
11.6
11
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.5
11.5
22
23
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
11.5
69
296
A41.9
ICD-10 Finland
Sepsis, unspecified
9.4
11.3
23
27
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.1
11.3
34
94
Z3226
NOMESCO Finland
Physiotherapist
3.0
11.3
64
266
TPH07
NOMESCO Finland
Cathetrisation of artery
3.7
11.2
40
125
Z3231
NOMESCO Finland
Registered nurse
2.7
11.2
85
412
TGC00
NOMESCO Finland
Bronchial lavation
9.3
10.8
22
26
B07.9
ICD-10 Finland
Verruca simplex
5.8
10.6
20
37
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
10.5
10
*
H26.3
ICD-10 Finland
Drug-induced cataract
34.3
10.4
13
*
B03XA01
ATC
erythropoietin; parenteral
24.7
10.4
14
6
R4110
NOMESCO Finland
Physiotherapy
2.6
10.3
86
434
ZXA00
NOMESCO Finland
Right side
2.6
10.1
79
385
Z49.2
ICD-10 Finland
Other dialysis
42.1
10.1
12
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
10.0
62
268
JN3AD
NOMESCO Finland
Abdominal CT examination
3.6
10.0
37
118
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.7
9.9
35
108
137
Kela drug reimbursment
Uraemia requiring dialysis
21.2
9.9
14
7
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
9.9
84
425
A02BC02
ATC
pantoprazole; systemic
2.7
9.8
168
1172
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
9.8
35
109
J01FF01
ATC
clindamycin; systemic
2.6
9.7
79
391
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
9.7
57
239
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.7
9.6
20
25
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.9
9.5
22
49
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
9.5
39
133
6BA02, ,
NOMESCO Finland
104.2
9.5
10
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
9.4
9
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
9.4
9
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
9.3
60
264
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
12.2
9.2
16
14
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.4
9.0
24
60
V03AE01
ATC
polystyrene sulfonate; oral
19.6
9.0
13
7
B05DB
ATC
Hypertonic solutions
25.2
9.0
12
5
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
11.4
8.9
16
15
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.5
8.8
20
29
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.1
8.8
19
40
205
Kela drug reimbursment
Chronic hypertension
2.5
8.7
73
364
A02BC03
ATC
lansoprazole; oral
2.4
8.6
83
441
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
8.4
8.5
18
23
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
8.5
22
54
H02AB09
ATC
hydrocortisone; systemic
9.1
8.5
17
20
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
8.4
8
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
8.4
8
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
8.4
8
*
4466A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Thrombotic microangiopathy
+∞
8.4
8
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.2
8.3
13
9
WX203
NOMESCO Finland
Infraclavicular plexus blockade
8.7
8.3
17
21
H65.2
ICD-10 Finland
Chronic serous otitis media
12.3
8.2
14
12
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
8.2
35
122
N05CD07
ATC
temazepam; oral
3.2
8.2
35
122
A07AA02
ATC
nystatin; oral
3.9
8.1
25
70
B05DA
ATC
Isotonic solutions
23.0
8.1
11
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.0
8.1
11
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
8.1
98
572
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.0
7.9
15
16
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.8
75
396
M05BA07
ATC
risedronic acid; oral
7.1
7.8
18
27
A10AC01
ATC
insulin (human); parenteral
3.3
7.7
31
104
M35.3
ICD-10 Finland
Polymyalgia rheumatica
12.5
7.7
13
11
Z2221
NOMESCO Finland
Medical doctor
2.3
7.6
80
437
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.6
7.6
17
24
Z49.0
ICD-10 Finland
Preparatory care for dialysis
26.0
7.6
10
*
J31.0
ICD-10 Finland
Chronic rhinitis
3.4
7.6
29
94
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
8.8
7.4
15
18
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
11.4
7.4
13
12
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
7.3
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
7.3
58
280
ZXE00
NOMESCO Finland
One hour or less
2.2
7.3
104
642
UDM02
NOMESCO Finland
Sinoscopy
8.4
7.2
15
19
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
31.1
7.2
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
7.2
107
670
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.4
7.1
16
23
R04.0
ICD-10 Finland
Epistaxis
3.5
7.1
26
82
M13.9
ICD-10 Finland
Arthritis, unspecified
3.6
7.1
24
72
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
7.0
32
116
C08CA01
ATC
amlodipine; oral
2.1
6.8
98
602
M05BB03
ATC
alendronic acid and colecalciferol; oral
7.6
6.8
15
21
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
41.3
6.8
8
*
H15.0
ICD-10 Finland
Scleritis
41.3
6.8
8
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
41.3
6.8
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
6.8
45
199
A02BC01
ATC
omeprazole; systemic
2.2
6.8
76
424
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.8
6.8
18
33
L88
ICPC
Rheumatoid/seropositive arthritis
6.3
6.8
17
29
ZXD05
NOMESCO Finland
Urgent procedure
2.1
6.7
85
497
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
6.7
29
102
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
12.8
6.7
11
9
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
6.6
27
91
AA1AD
NOMESCO Finland
CT of head and brain
2.2
6.6
69
373
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.6
6.6
22
65
R04.2
ICD-10 Finland
Haemoptysis
6.5
6.6
16
26
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
6.5
66
352
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
6.5
101
636
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
71.8
6.5
7
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
71.8
6.5
7
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.9
6.5
15
23
UKC02
NOMESCO Finland
Cystoscopy
2.5
6.4
44
198
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
9.7
6.4
12
13
M05BX04
ATC
denosumab; parenteral
3.9
6.3
19
52
J45.1
ICD-10 Finland
Nonallergic asthma
3.5
6.3
22
67
3AC01, ,
NOMESCO Finland
18.7
6.3
9
5
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.2
6.3
17
43
N085, M318,
ICD-10 Finland
+∞
6.3
6
*
4464A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Wegener's granulomatosis
+∞
6.3
6
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
6.3
6
*
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
+∞
6.3
6
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
8.0
6.2
13
17
ZXA05
NOMESCO Finland
Left side
2.2
6.1
67
368
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.3
6.1
24
79
J05AB01
ATC
aciclovir; systemic
2.2
6.0
60
317

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
61
67
12.12
52.97
9.2
1.9
1.34
1.42
g/l
0.20
54
56
43
28
18.75
50.78
7.2
1.1
—
—
—
0
0
45
44
12.53
41.83
4.2
1.2
10.36
—
iu/ml
—
9
0
90
217
6.25
38.28
6.4
2.4
26.00
23.11
%
0.72
79
187
176
791
6.63
35.41
23.7
6.0
—
—
—
0
0
169
773
5.77
32.10
23.0
5.4
0.58
0.64
%
0.72
169
722
177
843
6.15
31.93
22.3
5.2
0.64
0.57
e9/l
2.99
172
737
177
847
6.11
31.62
22.3
5.2
0.04
0.04
e9/l
0.31
171
740
35
36
11.33
31.14
1.4
1.4
—
—
—
0
0
62
128
6.31
30.47
5.9
2.8
85.82
67.55
e9/l
1.65
46
103
170
804
5.56
30.32
23.8
5.7
9.57
8.41
%
3.11
170
756
178
876
5.94
30.13
22.4
5.2
1.61
2.01
e9/l
2.15
171
792
169
800
5.47
29.97
23.2
5.4
2.42
2.71
%
1.08
169
751
178
881
5.89
29.77
23.5
5.6
0.17
0.18
e9/l
0.79
172
789
170
817
5.42
29.34
22.0
5.3
61.26
57.74
%
3.28
170
768
170
829
5.30
28.45
23.6
5.5
24.00
28.01
%
5.41
170
781
31
31
11.44
28.02
1.6
1.3
125.80
97.67
u/ml
—
5
6
30
30
11.38
27.09
2.1
1.1
6.36
5.00
u/ml
0.15
14
14
62
143
5.60
26.81
6.7
4.9
0.88
0.78
%
0.15
36
52
158
758
4.64
26.22
22.8
6.1
1.21
1.21
mmol/l
0.17
153
697
29
29
11.33
26.16
1.5
1.2
188.74
216.05
u/ml
0.11
23
21
125
513
4.23
25.67
14.6
3.8
7.39
7.40
ph
0.17
22
86
70
190
4.90
24.87
2.6
1.5
—
—
—
0
0
56
131
5.36
23.64
6.9
5.1
0.07
0.15
%
0.47
30
39
182
1019
5.11
23.34
26.6
8.7
4.42
4.22
e9/l
0.54
174
896
162
840
4.32
22.95
27.3
6.9
1.21
1.21
mmol/l
0.02
144
728
55
132
5.19
22.47
24.4
8.3
—
—
—
0
0
31
14
25.42
22.41
1.6
1.2
—
—
—
0
0
60
156
4.88
22.28
15.1
3.4
1.12
1.89
mmol/l
1.01
54
125
51
116
5.39
22.14
1.8
1.4
—
—
—
0
0
52
125
5.11
21.13
6.4
5.0
0.46
0.35
%
0.26
26
36
67
199
4.37
20.90
3.3
1.5
—
—
—
0
0
68
207
4.27
20.49
2.1
1.3
710.40
335.32
titre
1.34
25
47
78
264
3.99
20.28
7.6
3.5
0.81
0.82
mmol/l
0.08
73
253
108
460
3.59
19.81
9.0
4.1
—
—
—
0
0
89
335
3.74
19.73
2.5
2.0
—
—
—
0
0
123
570
3.55
19.71
11.4
3.1
34.68
155.14
e6/l
0.54
114
436
80
282
3.85
19.52
2.7
1.7
—
—
—
0
0
50
124
4.90
19.49
6.4
5.1
0.04
0.03
%
0.09
23
33
133
654
3.53
19.25
13.0
3.6
41.01
71.85
e6/l
0.60
119
465
114
510
3.50
19.21
10.7
2.9
—
—
—
0
0
115
520
3.48
19.00
9.8
3.1
6.94
7.67
mmol/l
1.09
109
448
141
727
3.52
18.74
13.6
4.5
34.04
35.73
g/l
2.65
135
692
33
58
6.50
18.65
7.1
1.5
22.06
20.90
s
0.91
33
52
109
482
3.45
18.58
9.0
3.3
147.51
64.75
mg/l
1.29
94
326
30
22
15.54
18.38
1.4
1.2
—
—
—
0
0
112
515
3.34
17.72
11.0
3.9
32.59
10.14
mg/mmol
1.75
94
334
32
58
6.27
17.52
1.5
1.2
—
—
—
0
0
73
262
3.64
17.07
3.7
2.1
—
—
—
0
0
111
517
3.26
17.03
11.7
3.0
0.24
0.32
e6/l
0.41
104
386
20
5
43.70
16.63
2.0
2.2
—
—
—
0
0
23
32
7.89
15.99
6.4
3.3
63.09
58.41
%
0.68
23
32
105
504
3.03
14.82
2.9
1.9
124.61
239.14
u/l
1.85
99
476
88
394
3.03
13.91
4.5
1.6
1.96
0.93
mg/l
3.65
78
315
98
466
2.95
13.89
6.4
2.6
368.63
7789.57
umol/l
2.40
91
402
55
192
3.47
13.11
13.6
9.4
0.53
1.20
mmol/l
0.60
42
153
148
896
2.90
13.02
9.4
3.4
0.00
0.01
estimate
0.50
36
183
92
439
2.85
12.74
10.0
3.4
97.98
91.21
%
1.41
92
431
42
125
3.90
12.66
2.9
2.3
60.64
66.27
g/l
3.02
42
112
147
897
2.84
12.56
12.7
4.6
0.00
0.00
estimate
-0.00
35
172
148
908
2.84
12.48
9.4
3.4
0.00
0.00
estimate
-0.00
34
164
85
397
2.83
12.17
8.2
3.4
—
—
—
0
0
20
17
12.79
11.58
1.2
1.3
—
—
—
0
0
56
213
3.17
11.51
18.5
6.4
103.71
104.29
mmol/l
0.37
56
213
36
103
3.97
11.42
10.3
3.6
7.41
7.41
ph
—
8
13
133
803
2.61
11.09
23.1
13.2
1.04
1.25
inr
4.83
37
261
26
59
4.85
11.05
6.5
3.5
0.60
0.26
g/l
0.68
19
21
68
295
2.87
11.04
9.0
2.8
1.52
2.75
e6/l
0.60
48
165
20
19
11.43
11.02
2.5
2.6
—
—
—
0
0
23
30
8.41
10.69
6.0
2.8
4.80
4.57
e9/l
0.14
23
30
35
103
3.84
10.65
3.1
1.9
—
—
—
0
0
54
212
3.04
10.44
2.5
1.4
—
—
—
0
0
90
467
2.55
10.12
19.8
6.7
—
—
—
0
0
129
790
2.48
10.11
29.3
8.8
0.01
0.00
e9/l
0.51
119
645
176
1249
2.88
10.10
14.6
4.0
—
—
—
0
0
22
48
4.97
9.76
3.2
2.5
—
—
—
0
0
103
580
2.43
9.58
4.3
2.3
—
—
—
0
0
103
581
2.43
9.54
5.6
3.2
2.35
2.35
mmol/l
0.01
94
522
154
1041
2.52
9.46
14.0
4.8
6.88
6.73
mmol/l
0.27
148
962
19
23
8.91
9.28
3.8
3.7
—
—
—
0
0
97
540
2.40
9.17
3.9
3.0
—
—
—
0
0
14
9
16.48
9.16
1.6
1.3
15.07
9.89
umol/l
—
14
9
21
32
7.12
8.90
2.0
1.3
—
—
—
0
0
15
13
12.26
8.71
1.5
1.2
—
—
—
0
0
17
19
9.58
8.70
1.2
1.2
—
—
—
0
0
26
72
3.95
8.57
9.3
3.8
—
—
—
0
0
19
27
7.58
8.45
3.4
5.3
—
—
—
0
0
39
143
3.09
8.39
1.8
1.3
—
—
—
0
0
79
417
2.38
8.27
3.4
2.0
3.27
3.03
mg/l
0.37
71
365
15
15
10.62
8.16
2.3
1.1
—
—
—
0
0
12
8
15.75
7.80
3.1
1.4
14.42
10.13
%
—
12
8
71
366
2.37
7.78
2.2
1.4
1.62
2.51
g/l
4.31
57
221
19
31
6.59
7.73
6.8
3.0
—
—
—
0
0
18
30
6.42
7.24
13.9
2.9
—
—
—
0
0
28
92
3.33
7.18
1.2
1.2
45.47
364.39
u/ml
0.68
23
85
16
24
7.09
6.95
14.1
1.8
74.28
65.07
%
0.90
16
24
35
136
2.86
6.76
8.6
3.2
—
—
—
0
0
26
86
3.29
6.59
20.0
13.9
—
—
—
0
0
18
47
4.08
6.40
4.6
1.6
35.31
38.42
g/l
1.01
18
41
9
5
18.66
6.31
3.2
2.2
—
—
—
0
0
15
24
6.61
6.28
1.6
2.3
—
—
—
0
0
13
17
8.04
6.21
4.2
2.9
1.66
1.47
g/24h
—
7
9
30
116
2.83
5.83
4.6
7.8
—
—
—
0
0
10
10
10.40
5.59
1.9
4.1
—
—
—
0
0
12
17
7.39
5.51
6.5
3.6
—
—
—
0
0
16
34
4.98
5.42
5.4
2.9
—
—
—
0
0
5
0
+∞
5.22
5.4
0.0
4.81
—
mg/l
—
5
0
12
20
6.27
4.98
1.9
3.0
—
—
—
0
0
61
350
2.02
4.86
4.1
3.8
220.27
216.53
ng/l
0.01
49
268
14
30
4.90
4.77
4.4
2.3
15.58
16.44
%
—
9
16
7
5
14.38
4.60
3.1
1.2
32.00
29.20
%
—
7
5
76
480
1.88
4.54
11.4
3.7
0.00
0.00
estimate
-0.00
32
166
8
9
9.16
4.31
1.3
1.2
—
—
—
0
0
7
6
11.98
4.30
1.1
1.2
—
—
—
0
0
14
34
4.32
4.29
3.6
3.0
1.66
2.83
mmol/l
—
8
22
13
30
4.53
4.20
5.5
2.5
—
—
—
0
0
65
403
1.86
4.05
1.5
1.5
16.65
20.40
nmol/l
1.76
57
339
7
7
10.27
4.04
1.3
1.0
—
—
—
0
0
7
7
10.27
4.04
2.4
3.7
2147.43
1005.86
u/ml
—
7
7
18
65
2.92
3.96
2.8
2.7
—
—
—
0
0
6
5
12.27
3.78
1.0
1.0
—
—
—
0
0
97
689
1.72
3.77
2.1
1.9
94.38
96.88
pmol/l
0.23
56
352
15
51
3.08
3.65
1.6
1.2
—
—
—
0
0
27
126
2.30
3.59
11.9
3.9
1.22
1.22
mmol/l
0.02
27
108
18
69
2.75
3.57
2.4
1.7
—
—
—
0
0
76
512
1.73
3.53
8.9
3.1
—
—
—
0
0
100
732
1.66
3.38
2.5
2.0
—
—
—
0
0
53
326
1.82
3.34
2.5
2.9
2.48
2.45
mmol/l
0.72
48
287
6
7
8.76
3.28
1.0
1.0
1335.67
1579.00
miu/ml
—
6
7
91
655
1.65
3.26
5.2
3.5
47.06
41.28
ng/l
0.15
71
438
8
15
5.49
3.22
1.8
1.1
—
—
—
0
0
7
11
6.53
3.21
1.4
1.0
—
—
—
0
0
22
100
2.33
3.11
1.6
1.2
—
—
—
0
0
6
8
7.67
3.07
5.7
2.5
—
—
—
0
0
29
149
2.09
3.07
13.3
4.1
—
—
—
0
0
8
17
4.84
2.94
1.0
1.2
—
—
—
0
0
7
13
5.52
2.89
1.0
1.2
—
—
—
0
0
6
9
6.81
2.88
1.5
1.1
—
—
—
0
0
15
59
2.65
2.85
1.3
1.2
—
—
—
0
0
7
14
5.12
2.75
1.4
1.1
—
—
—
0
0
6
10
6.13
2.71
5.7
2.6
—
—
—
0
0
8
19
4.32
2.70
1.3
1.4
86.23
90.62
%
—
8
19
9
25
3.70
2.60
5.7
2.5
—
—
—
0
0
12
44
2.82
2.59
1.5
1.5
320.43
282.58
ug/g
—
7
24
28
153
1.95
2.52
14.3
3.7
—
—
—
0
0
8
21
3.91
2.48
1.8
1.3
—
—
—
0
0
11
38
2.99
2.45
1.3
1.1
4.36
3.86
mmol/l
0.54
11
38
7
17
4.21
2.38
1.1
1.2
—
—
—
0
0
43
636
0.60
2.37
4.3
2.8
—
—
—
0
0
10
34
3.03
2.31
1.1
1.2
—
—
—
0
0
5
9
5.65
2.22
7.0
5.0
53.80
48.33
%
—
5
9
33
199
1.77
2.21
2.0
1.8
—
—
—
0
0
6
14
4.37
2.16
10.0
1.9
10.23
11.62
%
—
6
14
57
401
1.56
2.13
10.1
3.6
1.01
1.02
kg/l
—
6
54
7
20
3.58
2.07
5.6
2.2
35.86
32.55
pg
—
7
20
46
311
1.60
2.03
1.7
1.7
1153.62
1196.52
nmol/l
0.13
40
244
28
166
1.78
1.99
2.2
2.3
42.43
30.54
u/l
0.81
23
139
8
27
3.03
1.95
1.9
1.4
—
—
—
0
0
5
11
4.62
1.95
1.2
1.0
—
—
—
0
0
5
11
4.62
1.95
1.2
1.6
2.42
1.94
mmol/l
—
5
11
6
16
3.82
1.95
2.0
1.3
—
—
—
0
0
199
1834
1.74
1.90
50.0
12.9
18.48
23.35
mg/l
2.35
190
1432
5
12
4.23
1.83
1.6
1.4
13.26
13.41
ug/l
—
5
12
7
23
3.11
1.81
1.1
1.1
—
—
—
0
0
6
19
3.21
1.67
3.8
1.2
—
—
—
0
0
24
145
1.73
1.62
3.3
2.4
4.11
8.19
ug/l
1.11
19
127
11
50
2.26
1.59
1.6
1.6
—
—
—
0
0
6
21
2.91
1.51
1.2
1.1
277.83
279.06
mosm/kgh2o
—
6
16
6
21
2.91
1.51
1.2
1.1
—
—
—
0
0
13
67
2.00
1.41
9.2
4.1
—
—
—
0
0
16
89
1.86
1.41
9.2
3.4
—
—
—
0
0
47
346
1.45
1.41
1.7
1.7
166667078.45
468.61
pmol/l
0.49
42
295
5
17
2.98
1.36
3.0
3.8
35.84
101.04
u/ml
—
5
17
62
486
1.38
1.31
2.0
1.7
1.53
1.39
mmol/l
0.59
56
416
23
149
1.61
1.23
2.1
1.4
—
—
—
0
0
66
528
1.35
1.22
1.8
1.5
—
—
—
0
0
175
1616
1.37
1.17
55.8
15.8
15.17
14.89
%
0.32
175
1597
12
66
1.86
1.11
1.2
1.2
—
—
—
0
0
140
1257
1.30
1.11
5.4
3.6
—
—
—
0
0
8
41
1.99
1.10
3.1
2.1
—
—
—
0
0
8
41
1.99
1.10
1.1
1.1
—
—
—
0
0
5
23
2.20
0.98
1.2
1.2
—
—
—
0
0
50
397
1.33
0.97
1.4
1.3
2.82
1.38
u/ml
0.39
14
109
23
320
0.69
0.92
1.9
3.1
0.75
0.73
ug/l
0.06
16
213
162
1729
0.77
0.92
5.7
4.4
5.97
5.94
mmol/l
0.07
153
1586
11
63
1.78
0.92
1.1
1.3
262.20
281.61
miu/ml
—
5
31
8
43
1.89
0.88
3.0
3.3
1.44
1.41
mmol/l
—
8
43
20
137
1.50
0.87
1.2
1.2
—
—
—
0
0
31
234
1.38
0.83
1.4
1.2
—
—
—
0
0
149
1374
1.25
0.83
4.1
4.0
14.71
14.78
pmol/l
0.11
143
1238
12
186
0.63
0.81
1.3
1.4
—
—
—
0
0
26
192
1.40
0.79
1.8
1.8
—
—
—
0
0
172
1810
0.79
0.75
6.5
4.7
2.58
2.74
mmol/l
1.66
165
1675
7
42
1.69
0.69
3.3
3.2
7.94
7.48
mmol/l
—
7
42
169
1776
0.81
0.67
6.1
4.3
4.54
4.63
mmol/l
0.52
162
1656
5
28
1.80
0.66
3.8
2.4
3.50
5.14
umol/l
—
5
20
13
186
0.68
0.62
1.2
1.5
—
—
—
0
0
28
220
1.31
0.60
1.6
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
6
35
1.73
0.58
3.2
1.8
—
—
—
0
0
169
1763
0.83
0.52
6.1
4.2
1.45
1.46
mmol/l
0.11
161
1633
199
2043
0.78
0.52
70.7
19.3
38.46
40.30
%
5.35
183
1931
36
299
1.24
0.52
1.2
1.3
2.90
12.38
u/ml
—
10
122
24
192
1.28
0.47
1.5
1.3
—
—
—
0
0
175
1680
1.19
0.46
5.0
4.7
2.01
2.61
mu/l
0.39
165
1526
172
1650
1.18
0.45
8.1
5.6
38.99
39.82
mmol/mol
0.50
166
1547
8
57
1.42
0.42
5.1
4.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
185.66
—
0
16
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
15
117
1.30
0.36
5.5
2.7
—
—
—
0
0
6
45
1.34
0.34
12.7
1.6
—
—
—
0
0
21
175
1.22
0.31
3.0
4.5
3.11
73.94
ug/l
0.91
16
144
165
1701
0.89
0.30
5.6
3.9
1.46
1.27
mmol/l
2.53
157
1572
15
121
1.26
0.29
1.3
1.3
—
—
—
0
0
6
82
0.72
0.24
1.0
1.1
—
—
—
0
0
56
519
1.11
0.23
5.5
3.7
—
—
—
0
0
10
79
1.28
0.22
2.1
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
43.00
—
0
5
0
14
0.00
0.20
0.0
19.6
—
994.36
—
0
14
0
14
0.00
0.20
0.0
28.8
—
1940.07
—
0
14
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
34
311
1.11
0.18
1.2
1.3
38.29
35.90
iu/ml
—
10
95
8
71
1.13
0.16
5.0
1.4
—
—
—
0
0
6
80
0.74
0.15
1.2
1.1
—
—
—
0
0
5
63
0.79
0.08
18.2
9.8
—
—
—
0
0
5
63
0.79
0.08
2.8
1.4
338.80
320.64
mu/l
—
5
58
8
75
1.07
0.07
5.0
1.4
—
—
—
0
0
8
76
1.05
0.07
3.5
1.4
—
—
—
0
0
8
76
1.05
0.07
5.0
1.4
—
—
—
0
0
8
76
1.05
0.07
5.0
1.4
—
—
—
0
0
9
102
0.88
0.06
1.1
1.2
—
—
—
0
0
192
1933
0.95
0.05
37.6
12.1
—
—
—
0
0
55
553
0.99
0.00
3.4
4.8
1.83
2.61
ug/l
0.67
49
492
0
8
0.00
-0.00
0.0
1.8
—
1.48
—
0
8
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
53
0.94
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
53
0.94
-0.00
1.6
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.6
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
19.60
—
0
5
6
59
1.02
-0.00
6.3
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_HTROMBMICROANG and mortality.

Females

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 3.027 [2.31, 3.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 569 females with M13_HTROMBMICROANG died.

Males

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 2.429 [1.94, 3.05] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 411 males with M13_HTROMBMICROANG died.

Mortality risk

Mortality risk for people of age

years, who have M13_HTROMBMICROANG.

N-year risk Females Males
1 0.267% 0.436%
5 1.504% 2.909%
10 3.987% 7.723%
15 7.418% 14.785%
20 12.635% 24.923%

Relationships between endpoints

↥

Index endpoint: M13_HTROMBMICROANG – Thrombotic microangiopathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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