Crushing injury of ankle and foot

ST19_CRUSHI_INJURY_ANKLE_FOOT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — S97 Cause of death: ICD-10 — S97 2 out of 7 registries used, show all original rules.	133
4. Check minimum number of events None	133
5. Include endpoints None	133
6. Filter based on genotype QC (FinnGen only)	133

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_ANKLE_FOOT

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: S90
Name in latin: Conquassatio tarsi/pedis

NAME	ST19_CRUSHI_INJURY_ANKLE_FOOT
CONTROL_EXCLUDE	ST19_INJURI_ANKLE_FOOT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	S97
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	S97
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Crushing injury of ankle and foot based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	133	44	89
Unadjusted period prevalence (%)	0.03	0.01	0.04
Median age at first event (years)	49.65	48.81	50.07

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
118: Matched controls
1180

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S97.8

ICD-10 Finland

Crushing injury of other parts of ankle and foot

+∞

62.1

S97.1

ICD-10 Finland

Crushing injury of toe(s)

+∞

44.7

S97.0

ICD-10 Finland

Crushing injury of ankle

+∞

26.0

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

22.4

22.6

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

62.7

22.1

NHQ40

NOMESCO Finland

Amputation of toe

74.7

17.3

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

14.0

17.2

ZZA00

NOMESCO Finland

Split skin graft

19.3

14.1

NHJ50

NOMESCO Finland

Open reduction of fracture of foot or toe

+∞

13.8

QDE35

NOMESCO Finland

Repair of skin defect in lower limb after surgery or injury

144.8

12.7

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

15.8

12.5

SPAT1148

SPAT

Treatment of chronic ulcer or burn

6.0

11.2

S92.5

ICD-10 Finland

Fracture of other toe

48.3

11.2

W23

ICD-10 Finland

Caught, crushed, jammed or pinched in or between objects

48.3

11.2

X59

ICD-10 Finland

Exposure to unspecified factor

4.7

11.0

123

W31

ICD-10 Finland

Contact with other and unspecified machinery

16.3

10.9

TQW11

NOMESCO Finland

Vacuum treatment of wound

60.1

9.8

T93.6

ICD-10 Finland

Sequelae of crushing injury and traumatic amputation of lower limb

+∞

9.5

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.8

9.4

180

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

9.2

9.3

NH1AD

NOMESCO Finland

Ankle and foot CT

30.0

8.6

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

5.7

8.6

X58

ICD-10 Finland

Exposure to other specified factors

4.4

8.6

WX213

NOMESCO Finland

Lower leg blockade

+∞

8.4

J01FF01

ATC

clindamycin; systemic

3.3

7.4

185

A46

ICD-10 Finland

Erysipelas

4.3

7.4

S92.0

ICD-10 Finland

Fracture of calcaneus

+∞

7.4

S97

ICD-10 Finland

Crushing injury of ankle and foot

+∞

7.4

S97

ICPC

Chronic ulcer skin

8.4

7.2

W22

ICD-10 Finland

Striking against or struck by other object(s)

6.4

7.1

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

15.0

7.0

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

7.3

6.6

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

73.7

6.5

S92.3

ICD-10 Finland

Fracture of metatarsal bone

73.7

6.5

J01MA12

ATC

levofloxacin; systemic

3.5

6.4

114

S92.4

ICD-10 Finland

Fracture of great toe

+∞

6.3

QDE20

NOMESCO Finland

Excision and repair of scar or web of skin of lower limb

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

127

3.00

6.20

2.9

1.6

—

(3042936) Bacteria identified in Isolate by Culture

157

2.77

5.85

2.6

2.5

—

(3023368) Bacteria identified in Blood by Culture

273

2.26

4.61

4.7

5.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.66

3.41

2.3

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

123

1062

3.10

3.21

20.6

14.0

27.7

23.3

mg/l

0.66

103

842

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

2.44

3.21

2.1

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

104

2.34

2.95

2.0

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

332

1.81

2.65

2.7

2.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

7.36

2.57

1.0

—

(3032080) INR in Blood by Coagulation assay

425

1.75

2.54

15.7

9.1

1.4

1.2

inr

0.54

125

(3016879) Cocaine [Presence] in Urine

2.83

2.34

2.3

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.70

2.15

2.3

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.70

2.15

1.4

1.6

—

(3027008) Opiates [Presence] in Urine

2.70

2.15

2.3

1.4

—

(3027944) Amphetamines [Presence] in Urine

2.64

2.07

2.3

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

2.64

2.07

2.3

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

464

1.63

2.02

5.2

7.7

1.2

mmol/l

0.47

388

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.09

1.97

1.0

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.09

1.97

1.0

1.9

—

(42870588) Differential panel, method unspecified - Blood

339

1.65

1.96

5.5

5.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.30

1.91

1.3

2.0

181.9

244.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

360

1.62

1.88

2.9

3.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

117

1.94

1.88

3.8

3.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

3.64

1.86

1.2

1.8

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.64

1.86

1.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

118

1.93

1.83

1.2

1.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

618

1.58

1.82

6.0

5.4

7.1

6.7

mmol/l

0.72

573

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

134

1.87

1.81

13.4

7.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

150

1.82

1.79

2.8

1.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.44

1.76

1.0

1.8

—

(3003396) Base excess in Arterial blood by calculation

112

1.92

1.76

7.0

11.8

2.4

0.9

mmol/l

1.23

(3016502) Oxygen saturation in Arterial blood

105

1.94

1.74

7.3

12.1

95.2

0.00

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.26

1.68

1.2

1.8

—

(3027801) Oxygen [Partial pressure] in Arterial blood

115

1.87

1.64

7.0

11.4

11.0

11.9

kpa

0.51

108

(3044889) 12 lead EKG panel

759

1.57

1.63

4.1

3.9

—

(44790049)

3.67

1.63

1.0

1.7

—

(44790047)

3.67

1.63

1.0

1.7

—

(44790048)

3.67

1.63

1.0

1.7

—

(44806118)

3.67

1.63

1.0

1.7

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.01

1.57

4.5

7.3

1.8

1.3

mmol/l

1.23

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.68

1.53

1.0

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

755

1.54

1.52

4.5

3.7

13.1

10.7

mm/h

0.64

689

(3011397) Hemoglobin [Presence] in Urine by Test strip

226

1.61

1.48

4.2

3.5

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.88

1.47

8.0

13.1

126.6

122.3

g/l

0.37

(3010813) Leukocytes [#/volume] in Blood

128

1207

2.61

1.46

27.7

20.0

6.8

6.7

e9/l

0.25

123

1174

(3026361) Erythrocytes [#/volume] in Blood

128

1207

2.61

1.46

27.7

19.9

4.6

e12/l

0.28

123

1174

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

491

1.49

1.45

4.5

4.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.00

1.45

1.6

1.7

—

(3011288) Drugs identified in Urine by Screen method

2.81

1.45

2.8

1.9

—

(3028707) Methadone [Presence] in Urine by Screen method

3.20

1.45

3.4

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

708

1.51

1.45

5.1

4.1

—

(3026008) Bacteria identified in Urine by Culture

281

1.55

1.42

3.8

2.9

—

(40758558) Short blood count panel - Blood

246

1.57

1.41

7.5

6.4

—

(3015736) pH of Urine

400

1.49

1.39

3.9

3.6

—

(3037756) Immunofixation for Serum or Plasma

3.01

1.37

1.0

1.1

—

(3006504) Eosinophils/100 leukocytes in Blood

478

1.47

1.34

6.1

5.8

2.5

2.8

0.51

450

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.57

1.32

1.2

1.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.17

1.31

2.7

2.1

—

(36304419) Bacteria [Presence] in Urine

268

1.53

1.31

3.1

2.7

—

(3000492) Spirometry study

108

1.77

1.30

1.6

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

278

1.51

1.28

3.2

2.8

0.4

0.6

e6/l

0.23

203

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

669

1.45

1.25

3.3

3.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

316

1.48

1.24

3.1

2.7

2226.8

1491.2

ng/l

0.26

255

(3009261) Glucose [Presence] in Urine by Test strip

532

1.43

1.23

4.4

3.6

0.0

estimate

0.00

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

245

1.52

1.22

2.6

2.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.69

1.22

1.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.69

1.22

1.2

1.6

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

438

1.44

1.20

5.1

6.6

1.2

mmol/l

1.17

391

(3035350) Ketones [Presence] in Urine by Test strip

518

1.41

1.14

4.4

3.6

0.0

estimate

0.00

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.74

1.13

1.6

2.1

344.1

373.6

nmol/l

0.30

(3021601) Nitrite [Presence] in Urine by Test strip

520

1.40

1.11

5.6

4.9

0.0

estimate

0.00

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

559

1.40

1.11

5.4

6.9

12.8

11.1

umol/l

0.44

530

(3019309) Folate [Moles/volume] in Red Blood Cells

172

1.56

1.10

2.0

1.7

1104.9

1299.3

nmol/l

0.55

133

(40761535) Cells panel - Urine sediment

1.81

1.07

5.0

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

380

1.41

1.07

2.2

1.8

96.1

95.6

pmol/l

0.02

188

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

217

1.49

1.06

1.4

1.7

1.0

1.4

mg/l

0.66

174

(3013115) Eosinophils [#/volume] in Blood

533

1.39

1.06

5.8

6.0

0.2

e9/l

0.66

472

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.12

1.04

1.6

2.9

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.88

1.02

4.5

3.5

147.5

219.9

ng/l

0.41

(3018095) Leukocytes [#/volume] in Urine

365

1.40

1.00

3.5

3.4

29.2

72.7

e6/l

0.75

257

(3013650) Neutrophils [#/volume] in Blood by Automated count

606

1.37

0.99

8.5

9.3

4.4

4.1

e9/l

0.23

533

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.99

0.0

1.6

—

246.9

—

(3012544) pH of Venous blood

1.69

0.99

1.5

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

314

1.39

0.92

3.1

3.0

24.6

225.9

e6/l

0.48

237

(3001604) Monocytes [#/volume] in Blood

514

1.35

0.90

5.8

5.7

0.6

e9/l

0.21

448

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.91

0.89

1.6

1.8

—

(3006315) Basophils [#/volume] in Blood

515

1.34

0.89

5.8

0.0

e9/l

0.17

451

(3020779) Urea [Moles/volume] in Serum or Plasma

1.69

0.88

3.1

8.7

7.7

9.5

mmol/l

0.86

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

420

1.35

0.87

4.8

3.5

70.6

45.1

ng/l

0.24

300

(3019198) Lymphocytes [#/volume] in Blood

527

1.33

0.85

6.1

5.9

1.8

e9/l

0.11

470

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.80

0.0

5.5

—

1008.0

—

(3018418) pH of Serum or Plasma

276

1.36

0.78

2.7

3.8

7.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.75

0.77

2.4

2.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.22

0.77

1.4

1.3

—

(4094501)

2.22

0.77

1.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.12

0.75

2.4

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.72

0.74

1.5

4.2

132.2

129.5

g/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

827

1.32

0.73

7.4

7.6

87.2

79.4

u/l

0.59

771

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

180

1.41

0.71

4.1

3.8

307.8

151.6

ng/l

0.22

141

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.65

0.71

12.7

13.3

25.5

24.5

mmol/l

0.45

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

111

1041

1.40

0.70

4.5

4.4

5.9

6.0

mmol/l

0.60

945

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.75

0.64

1.2

1.4

—

(3019060) Gas panel - Arterial blood

1.60

0.64

8.0

10.9

—

(3021589) Normoblasts [#/volume] in Blood

466

1.27

0.63

10.1

9.2

0.0

e9/l

0.53

381

(3012516) Albumin [Mass/volume] in Urine

295

1.30

0.62

3.1

3.4

1403.4

94.1

mg/l

0.47

197

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

765

1.27

0.61

2.9

3.8

14.4

14.9

pmol/l

0.91

692

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.57

0.61

1.5

3.5

27.4

24.9

mmol/l

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

0.60

0.0

3.2

—

0.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.61

0.60

1.2

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

115

1092

1.39

0.60

4.7

4.9

2.7

mmol/l

0.07

101

1007

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

108

1017

1.33

0.59

15.6

12.4

84.4

83.6

ml/min/173m2

0.13

811

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

161

1.36

0.56

2.3

2.7

0.6

2.3

e6/l

1.42

(3000330) Specific gravity of Urine by Test strip

1.54

0.56

1.8

3.8

—

(40761536) Microorganisms panel - Urine sediment

1.44

0.50

7.8

3.2

—

(3019150) Specific gravity of Urine by Refractometry

238

1.28

0.50

4.6

4.2

1.0

kg/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

104

982

1.27

0.49

22.4

13.9

39.7

40.5

0.31

712

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

102

962

1.26

0.48

3.9

4.3

2.0

1.9

mu/l

0.28

875

(21494755) Public health laboratory ask at order entry panel

116

0.67

0.48

1.4

—

(1002224) Polysomnography panel

1.48

0.47

1.0

—

(4010399)

1.45

0.44

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.58

0.42

2.2

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

386

1.21

0.42

2.2

73.7

72.7

nmol/l

0.08

336

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.53

0.42

1.2

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

310

1.22

0.41

3.2

7.2

8.0

mmol/l

0.47

261

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

142

1.31

0.41

1.3

22.7

43.0

iu/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

171

1.27

0.39

2.4

2.5

0.8

e6/l

0.04

104

(40761511) CBC panel - Blood by Automated count

117

1130

1.29

0.38

19.3

13.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.41

0.35

1.7

1.8

—

(3020891) Body temperature

1.32

0.33

10.0

3.4

—

(3000991) Gas panel - Venous blood

1.38

0.33

5.9

8.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

104

998

1.19

0.32

7.1

5.7

40.3

40.2

mmol/mol

0.03

937

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.31

0.31

10.3

18.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

122

1.26

0.28

2.7

2.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

312

1.17

0.28

3.7

4.3

7.1

16.5

mg/mmol

1.27

206

(3022621) pH of Urine by Test strip

1.32

0.27

2.3

2.0

—

(40768797) Stomach Pathology biopsy report

133

1.23

0.25

1.3

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

257

1.16

0.25

3.5

5.5

—

(3003694) ABO and Rh group [Type] in Blood

296

1.15

0.24

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.72

0.23

1.3

1.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.29

0.23

6.6

17.0

1.0

0.9

—

(4034850)

1.26

0.22

7.2

12.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

101

0.78

0.22

1.3

1.4

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.20

0.21

6.6

15.9

1.5

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

1.9

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.0

—

38.4

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.5

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

478.0

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

267.6

—

(4062490)

0.00

0.21

0.0

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.7

—

89.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.7

—

(1761868) Lipid panel - Serum or Plasma

423

0.89

0.20

2.4

2.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.26

0.20

1.5

2.7

1.7

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

176

1.16

0.18

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

215

0.86

0.18

2.1

1.8

411.7

424.3

pmol/l

0.08

180

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.18

0.18

1.1

—

(3025941) Bacteria identified in Stool by Culture

0.73

0.17

1.4

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

306

0.89

0.16

2.8

2.9

0.5

0.7

ug/l

0.84

193

(3015377) Calcium [Moles/volume] in Serum or Plasma

334

1.11

0.16

2.0

3.5

2.3

mmol/l

0.13

292

(3019225) pH of Specimen

103

1.18

0.14

2.6

3.9

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

109

1068

1.11

0.14

4.5

4.4

4.5

4.6

mmol/l

0.41

993

(3019832) Treponema pallidum Ab [Presence] in Serum

105

0.85

0.13

2.0

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

416

1.09

0.13

5.5

3.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

158

0.87

0.13

1.3

1.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

106

1039

1.10

0.12

3.9

4.0

1.3

mmol/l

0.29

956

(46235355) HIV 1 and 2 tests - Meaningful Use set

208

0.90

0.11

2.3

1.9

—

(3045414) Leukocytes [Presence] in Urine

1.12

0.10

1.6

1.3

—

(40768443) Skin Pathology biopsy report

1.09

0.09

1.2

1.1

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.07

0.09

1.0

1.3

243.0

215.5

u/ml

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.83

0.08

2.8

2.5

3.7

1.5

mmol/l

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.77

0.08

2.8

2.5

5.6

5.1

kpa

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

108

1065

1.07

0.07

4.3

1.3

1.4

mmol/l

1.10

986

(3029937) Albumin [Presence] in Urine by Test strip

285

1.07

0.07

6.9

3.9

0.0

estimate

0.00

(36660697) Celiac disease serology panel - Serum

0.82

0.07

1.4

1.1

—

(3013512) EKG study

317

1.05

0.05

5.7

3.8

—

(40768804) Tissue Pathology biopsy report

397

1.05

0.05

1.8

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

308

1.05

0.05

4.6

3.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

539

1.03

0.03

4.0

4.6

1.2

2.7

ug/l

1.65

482

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

781

0.97

0.03

3.7

3.4

83.3

52.4

u/l

0.94

729

(3002256) Pathology report gross observation

118

0.93

0.03

1.1

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

228

0.96

0.02

1.3

1.2

0.6

0.9

u/ml

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

126

0.95

0.00

1.1

1.6

—

(3022145) Colonoscopy Study observation

109

1.01

0.00

1.5

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

111

0.99

0.00

1.9

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

209

1.01

0.00

1.4

3.2

2.7

g/l

0.55

135

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

432

0.99

0.00

3.7

4.2

25.7

20.9

0.87

200

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

138

1.02

0.00

3.1

2.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

125

1.04

0.00

1.3

1.4

1.1

14.7

u/ml

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.1

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

6.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.99

0.00

1.3

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

5.7

—

25.4

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.2

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

1.4

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.8

—

11.8

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

1.6

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.4

—

0.6

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1559.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.6

—

157.9

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.4

—

(4211845)

0.00

0.0

1.3

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

1211.8

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.96

0.00

1.0

1.6

—

(4024509)

0.00

0.0

1.3

—

(3021162) Amylase [Enzymatic activity/volume] in Specimen

0.00

0.0

2.2

—

10944.8

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.3

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3034037) Hematocrit [Volume Fraction] of Mixed venous blood

0.00

0.0

13.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.6

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.6

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(3006576) Bicarbonate [Moles/volume] in Blood

0.00

0.0

10.2

—

26.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.2

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_CRUSHI_INJURY_ANKLE_FOOT – Crushing injury of ankle and foot

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Crushing injury of ankle and foot

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Crushing injury of ankle and foot (ST19_CRUSHI_INJURY_ANKLE_FOOT)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints