Typhoid and paratyphoid fevers

AB1_TYPHOIDPARATHYPHOID

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A01 Hospital discharge: ICD-9 — 002. Hospital discharge: ICD-8 — 00[1-2] Cause of death: ICD-10 — A01 Cause of death: ICD-9 — 002. Cause of death: ICD-8 — 00[1-2] 2 out of 7 registries used, show all original rules.	169
4. Check minimum number of events None	169
5. Include endpoints None	169
6. Filter based on genotype QC (FinnGen only)	169

Control definitions (FinnGen only)

Control exclude: AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_TYPHOIDPARATHYPHOID
CONTROL_EXCLUDE	AB1_INTESTINAL_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A01
HD_ICD_9	002.
HD_ICD_8	00[1-2]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A01
COD_ICD_9	002.
COD_ICD_8	00[1-2]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Typhoid and paratyphoid fevers based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1560	772	765
Only index persons	1249	640	609
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	34.76	36.42	32.62
Only index persons	29.08	30.04	28.08

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	169	100	69
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	36.36	35.40	37.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
146: Matched controls
1461

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

00210

ICD-8 Finland

Paratyphoid fever B

+∞

26.9

A01.0

ICD-10 Finland

Typhoid fever

+∞

24.7

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

6.1

10.8

00299

ICD-8 Finland

Paratyphoid fever unspecified

+∞

10.5

A01.4

ICD-10 Finland

Paratyphoid fever, unspecified

+∞

9.5

M01.3*A01.4

ICD-10 Finland

Arthritis in typhoid or paratyphoid fever

+∞

8.4

00199

ICD-8 Finland

Typhoid fever, Unspecified

+∞

8.4

I39.8*A01.0

ICD-10 Finland

Endocarditis in typhoid fever

+∞

7.3

0020A

ICD-9 Finland

Typhoid and paratyphoid fevers, Typhoid fever

+∞

7.3

0022A

ICD-9 Finland

Typhoid and paratyphoid fevers, Paratyphoid fever B

+∞

7.3

A01.1

ICD-10 Finland

Paratyphoid fever A

+∞

7.3

0029X

ICD-9 Finland

Typhoid and paratyphoid fevers, Paratyphoid fever, unspecified

+∞

6.3

R50.9

ICD-10 Finland

Fever, unspecified

3.4

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.89

5.35

1.3

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.70

3.70

1.8

1.4

—

(3042936) Bacteria identified in Isolate by Culture

178

2.14

3.52

2.5

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

527

1.72

2.94

2.1

1.9

92.1

97.6

pmol/l

0.44

274

(3048689) Calprotectin [Mass/mass] in Stool

155

2.05

2.83

3.0

2.4

200.5

119.5

ug/g

0.67

125

(1761482) Bacteria [#/volume] in Urine by Culture

3.37

2.82

5.6

5.1

—

(3003396) Base excess in Arterial blood by calculation

143

2.06

2.70

11.5

6.4

1.8

1.3

mmol/l

0.37

114

(3027801) Oxygen [Partial pressure] in Arterial blood

144

2.04

2.65

11.4

6.3

11.7

12.2

kpa

0.23

139

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

144

2.04

2.65

11.4

6.3

5.0

5.1

kpa

0.38

139

(3023368) Bacteria identified in Blood by Culture

328

1.74

2.62

5.2

4.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

559

1.65

2.60

2.6

2.2

82.0

76.8

nmol/l

0.68

507

(3019060) Gas panel - Arterial blood

2.34

2.58

4.2

3.8

—

(3025941) Bacteria identified in Stool by Culture

2.46

2.57

1.3

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.46

2.43

1.2

1.4

—

(3026008) Bacteria identified in Urine by Culture

378

1.67

2.41

4.9

2.9

—

(3012544) pH of Venous blood

108

2.08

2.27

4.8

3.0

—

(3000330) Specific gravity of Urine by Test strip

2.41

2.21

4.1

3.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

193

1.81

2.20

1.9

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

779

1.58

2.19

7.3

4.1

6.6

6.7

mmol/l

0.02

715

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

653

1.57

2.19

9.6

5.5

1.2

mmol/l

0.55

542

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.01

2.10

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.22

1.88

1.0

1.1

—

(36660697) Celiac disease serology panel - Serum

102

1.97

1.85

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

605

1.50

1.82

7.2

3.7

—

(3022313) Gas panel - Capillary blood

2.43

1.82

4.6

3.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

3.42

1.76

3.2

2.6

—

(3005570) Glucose [Moles/volume] in Urine

3.93

1.72

1.0

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

143

1.79

1.72

1.8

1.7

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

710

1.46

1.66

5.7

5.5

10.0

11.1

umol/l

1.25

670

(3019069) Monocytes/100 leukocytes in Blood

634

1.46

1.63

8.3

5.3

8.5

8.6

0.10

594

(3044640) Blood type and Crossmatch panel - Blood

393

1.51

1.62

4.6

2.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

782

1.46

1.60

12.2

9.2

3.9

4.0

e9/l

0.28

685

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.07

1.59

1.0

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

140

1.74

1.55

2.0

1.7

—

(40758558) Short blood count panel - Blood

352

1.51

1.54

8.2

6.9

—

(42870588) Differential panel, method unspecified - Blood

434

1.47

1.52

7.1

4.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

105

898

1.45

1.51

5.5

4.1

—

(3006504) Eosinophils/100 leukocytes in Blood

632

1.43

1.50

7.9

5.0

2.7

2.8

0.04

592

(3022096) Basophils/100 leukocytes in Blood

615

1.43

1.47

7.9

4.9

0.6

0.7

0.24

571

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

3.19

1.45

1.8

1.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

120

1057

1.47

1.44

8.6

6.6

78.9

77.8

u/l

0.11

113

987

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.02

1.42

19.9

6.9

—

(21494755) Public health laboratory ask at order entry panel

150

0.44

1.39

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

654

1.39

1.30

8.1

5.1

27.7

28.9

0.48

607

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.10

1.29

3.8

2.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

293

1.48

1.28

1.3

1.2

0.5

1.1

u/ml

—

(3019225) pH of Specimen

108

1.75

1.28

7.0

3.7

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

588

1.39

1.28

8.7

5.0

1.2

mmol/l

0.81

539

(3018010) Neutrophils/100 leukocytes in Blood

646

1.39

1.27

8.0

4.8

57.1

56.4

0.27

605

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

260

1.49

1.24

4.3

3.8

2791.7

268.0

ng/l

0.43

201

(3009343) pH of Capillary blood

1.90

1.23

4.5

3.4

—

7.4

—

(3044941) Cell count panel - Synovial fluid

2.68

1.22

1.0

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.54

1.16

1.0

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.85

1.14

1.5

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.05

1.13

1.5

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.05

1.13

1.5

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.05

1.13

1.5

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

2.31

1.12

2.0

3.5

—

(3006315) Basophils [#/volume] in Blood

676

1.35

1.11

8.3

5.2

0.0

e9/l

0.04

586

(3007853) Bacteria identified in Skin by Aerobe culture

154

1.57

1.11

2.2

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.00

1.10

1.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

284

1.44

1.10

2.7

2.3

—

(3035350) Ketones [Presence] in Urine by Test strip

658

1.34

1.09

3.6

3.8

0.0

estimate

0.00

125

(3013115) Eosinophils [#/volume] in Blood

700

1.33

1.05

8.8

5.5

0.2

e9/l

0.68

617

(3050129) First trimester maternal screen panel - Serum or Plasma

2.31

1.04

1.4

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.31

1.04

1.0

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.31

1.04

1.0

1.5

—

(3047181) Lactate [Moles/volume] in Blood

2.04

1.01

9.4

4.7

1.1

1.2

mmol/l

—

(3001604) Monocytes [#/volume] in Blood

675

1.32

0.99

8.3

5.1

0.6

e9/l

0.13

581

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.80

0.99

1.8

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

695

1.32

0.99

8.2

5.2

1.7

2.1

e9/l

1.17

614

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.21

0.98

1.0

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.75

0.98

1.0

1.2

—

(40768804) Tissue Pathology biopsy report

523

1.33

0.96

2.6

2.1

—

(3036489) Thrombin time

1.95

0.90

1.3

1.7

19.8

22.6

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.90

0.88

3.5

3.9

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

519

1.31

0.88

3.8

4.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

378

1.34

0.88

3.1

3.5

—

(1002224) Polysomnography panel

1.77

0.88

1.2

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.04

0.88

1.0

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

306

1.36

0.86

2.4

2.0

2.7

3.2

mg/l

0.56

259

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

116

1059

1.30

0.83

4.2

3.9

14.7

14.6

pmol/l

0.07

110

962

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.80

0.0

3.2

—

3.9

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.80

0.0

1.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.79

0.0

3.2

—

56.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.79

0.0

3.3

—

(3015736) pH of Urine

507

1.28

0.79

3.8

3.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

576

1.27

0.76

3.1

2.6

186.4

116.4

ug/l

0.39

536

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

141

1330

1.36

0.75

4.9

4.4

6.1

5.9

mmol/l

0.42

134

1227

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.62

0.74

2.4

3.3

0.2

0.1

e6/l

0.12

(3009261) Glucose [Presence] in Urine by Test strip

676

1.26

0.73

3.8

0.0

estimate

0.00

120

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

1.95

0.71

1.8

1.1

0.8

nmol/l

—

(40768443) Skin Pathology biopsy report

1.58

0.71

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.74

0.71

1.7

2.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

119

1.48

0.70

1.8

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.65

0.67

1.9

2.4

—

(3028707) Methadone [Presence] in Urine by Screen method

1.81

0.66

1.6

—

(3020891) Body temperature

1.66

0.63

3.9

3.6

—

(3000494) Fungus identified in Specimen by Culture

157

1.39

0.63

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

313

1.28

0.60

1.8

1.6

1.0

1.1

mg/l

0.05

250

(40768795) Lymph node Pathology biopsy report

0.00

0.60

0.0

1.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

668

1.22

0.60

5.9

5.0

0.0

estimate

0.00

122

(40768800) Prostate Pathology biopsy report

0.00

0.58

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.74

0.58

1.7

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

234

1.29

0.54

1.4

1.9

878.6

1225.6

nmol/l

1.40

178

(3007164) IgA [Mass/volume] in Serum or Plasma

271

1.27

0.54

1.3

1.4

2.2

2.6

g/l

0.59

178

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.56

0.53

1.2

1.7

89.5

92.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.45

0.53

1.9

2.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.52

0.52

3.2

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.41

0.51

1.8

1.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

143

0.68

0.50

1.7

—

(3032080) INR in Blood by Coagulation assay

534

1.19

0.47

8.8

8.4

1.2

inr

0.05

153

(40768797) Stomach Pathology biopsy report

177

1.28

0.43

1.2

—

(3013512) EKG study

374

1.20

0.43

4.0

3.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.46

0.42

1.5

2.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.58

0.42

1.0

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.53

0.41

1.0

1.6

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(40761536) Microorganisms panel - Urine sediment

102

0.67

0.41

2.7

3.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.35

0.41

1.3

2.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.40

0.0

1.1

—

0.9

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.40

0.0

1.7

—

33.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.44

0.39

1.0

1.2

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.39

0.0

1.1

—

3.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.39

0.0

1.8

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.39

0.0

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

503

1.17

0.39

3.9

3.5

26.5

38.9

ng/l

0.47

331

(3011397) Hemoglobin [Presence] in Urine by Test strip

302

1.20

0.38

4.1

3.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

135

1299

1.20

0.37

13.6

12.4

83.2

82.0

ml/min/173m2

0.27

110

1066

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

418

1.17

0.37

3.1

2.3

53.0

56.1

u/l

0.27

383

(3021589) Normoblasts [#/volume] in Blood

613

1.15

0.36

9.6

9.0

0.0

e9/l

1.23

494

(46235355) HIV 1 and 2 tests - Meaningful Use set

200

1.23

0.36

1.6

2.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.41

0.35

1.5

—

(3000991) Gas panel - Venous blood

100

1.32

0.34

20.5

7.2

—

(3000850) Epithelial cells [#/volume] in Urine

281

0.83

0.32

2.5

2.4

8.9

4.2

e6/l

1.08

248

(3024561) Albumin [Mass/volume] in Serum or Plasma

572

1.13

0.29

6.0

3.6

34.7

36.0

g/l

0.80

538

(4035726)

117

0.76

0.28

1.1

1.4

—

(3018095) Leukocytes [#/volume] in Urine

485

1.14

0.28

3.8

3.6

42.6

134.3

e6/l

0.85

337

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

208

1.18

0.25

3.2

2.8

5.4

3.8

e6/l

0.16

106

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

865

0.90

0.25

3.6

3.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.70

0.24

1.7

1.8

—

(3044889) 12 lead EKG panel

102

977

1.11

0.24

3.9

3.7

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.36

0.24

1.4

2.6

1.4

1.5

mg/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.36

0.24

1.6

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

393

1.13

0.23

3.2

2.8

6.6

7.7

mmol/l

1.19

343

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

131

1274

1.13

0.22

5.8

5.3

39.4

39.6

mmol/mol

0.11

126

1196

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.23

0.22

1.0

2.3

—

3906.8

—

(3011288) Drugs identified in Urine by Screen method

1.23

0.22

2.8

1.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.3

—

13.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

1.1

—

(4211845)

0.00

0.21

0.0

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.5

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

5.6

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

10.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

107

1032

1.10

0.20

5.1

3.8

14.3

10.9

mm/h

1.34

100

948

(40761535) Cells panel - Urine sediment

115

0.77

0.20

4.3

3.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.1

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

279.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.20

0.0

1.5

—

6.9

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.20

0.0

1.1

—

36.9

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.6

—

2.6

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

489.7

—

(3002385) Erythrocyte distribution width [Ratio]

112

1155

0.91

0.19

25.1

16.4

13.5

13.7

0.62

112

1136

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

398

1.11

0.19

4.1

4.6

1.9

2.5

ug/l

0.71

353

(3009542) Hematocrit [Volume Fraction] of Blood

128

1250

1.10

0.17

23.3

13.7

38.1

40.2

1.24

957

(3020682) Albumin/Creatinine [Ratio] in Urine

372

1.10

0.16

3.7

3.5

7.7

mg/mmol

1.24

241

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

942

0.93

0.16

3.5

2.8

53.1

45.6

u/l

0.44

880

(3029937) Albumin [Presence] in Urine by Test strip

367

0.91

0.15

4.0

4.2

0.0

estimate

0.00

119

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

254

0.89

0.15

1.7

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

129

0.84

0.15

1.7

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

132

1293

1.10

0.15

3.9

1.5

1.3

mmol/l

1.22

122

1192

(3015377) Calcium [Moles/volume] in Serum or Plasma

453

1.08

0.14

3.2

2.9

2.4

mmol/l

0.25

401

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

129

1265

1.08

0.13

5.1

4.6

2.0

1.9

mu/l

0.23

123

1160

(1761868) Lipid panel - Serum or Plasma

536

0.93

0.13

3.1

2.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.19

0.12

2.2

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

148

1460

1.11

0.12

20.7

15.1

79.5

76.4

umol/l

0.29

148

1460

(3022621) pH of Urine by Test strip

1.17

0.12

3.6

2.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

132

1342

0.93

0.12

4.5

4.3

1.5

mmol/l

0.01

123

1241

(3030467) Casts [#/volume] in Urine by Automated count

368

1.08

0.11

2.9

2.8

0.0

0.5

e6/l

2.87

267

(3017143) Hepatitis C virus Ab [Presence] in Serum

144

1.12

0.11

1.9

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

156

0.89

0.10

1.4

2.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.17

0.10

1.8

1.4

—

(3003694) ABO and Rh group [Type] in Blood

370

1.07

0.10

1.3

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

410

1.07

0.09

3.1

3.0

21.1

238.1

e6/l

0.74

308

(3049717) Cytology report of Urine Cyto stain

1.07

0.09

2.2

2.6

—

(3012516) Albumin [Mass/volume] in Urine

358

0.94

0.09

2.8

2.9

2781.7

410.6

mg/l

0.39

228

(36304419) Bacteria [Presence] in Urine

367

0.94

0.08

2.8

2.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

139

1374

1.07

0.07

20.3

12.9

26.6

22.6

mg/l

0.61

113

1051

(3004588) Protein electrophoresis panel - Serum or Plasma

1.09

0.07

5.4

2.0

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.08

0.07

1.1

1.3

—

25.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.86

0.07

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

316

1.06

0.06

4.0

4.3

22.3

22.2

0.01

138

(3002256) Pathology report gross observation

178

1.08

0.06

1.6

1.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.12

0.05

2.9

4.5

4.4

pmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

317

1.05

0.05

3.9

5.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

136

1373

0.95

0.05

5.2

4.8

2.7

2.8

mmol/l

0.40

126

1271

(40761511) CBC panel - Blood by Automated count

145

1438

1.06

0.05

17.8

12.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

150

0.93

0.04

8.7

7.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

220

1.05

0.04

3.0

2.5

1.2

1.1

e6/l

0.07

119

(3022145) Colonoscopy Study observation

131

1.07

0.03

1.1

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

241

1.04

0.03

1.6

1.3

12.9

15.4

u/ml

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

299

0.96

0.02

1.4

1.8

429.6

458.6

pmol/l

0.37

255

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

168

0.95

0.02

1.6

—

(4010399)

103

1.07

0.02

1.2

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

207

0.96

0.01

1.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.04

0.00

2.7

2.4

—

5.1

—

(3019150) Specific gravity of Urine by Refractometry

309

1.00

0.00

4.0

4.2

1.0

kg/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

481

1.00

0.00

2.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

143

0.98

0.00

1.5

2.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

237

1.01

0.00

2.7

2.8

0.5

0.9

ug/l

1.56

137

(3031040) Bacteria [#/volume] in Urine by Automated count

857

1.01

0.00

6.2

4.3

—

348.3

—

(3000492) Spirometry study

132

0.98

0.00

2.2

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

128

1.02

0.00

3.0

3.4

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.8

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.8

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.6

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

6.6

—

(3009876) Amylase isoenzyme 3 panel - Serum or Plasma

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(3016879) Cocaine [Presence] in Urine

0.96

0.00

2.8

1.4

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

3.1

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3045684) Alkaline phosphatase.other fractions [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

17.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.87

0.00

2.8

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.84

0.00

2.8

1.4

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(3035400) Alkaline phosphatase.liver [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

85.7

—

(3028300) Cannabinoids [Presence] in Urine

0.84

0.00

2.8

1.4

—

(3000012) Reticulocyte production index

0.00

0.0

2.6

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

240.6

—

(4027681)

0.00

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

0.86

0.00

1.6

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.96

0.00

1.6

1.9

—

(3005685) Amylase.salivary [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

52.4

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.8

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3022689) Creatine [Moles/volume] in Urine

0.00

0.0

1.8

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.1

—

251.7

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

203.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

135

1350

1.00

0.00

4.5

4.3

4.7

mmol/l

0.00

126

1253

(3027008) Opiates [Presence] in Urine

0.84

0.00

2.8

1.4

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(4198724)

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_TYPHOIDPARATHYPHOID and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_TYPHOIDPARATHYPHOID.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_TYPHOIDPARATHYPHOID – Typhoid and paratyphoid fevers

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Typhoid and paratyphoid fevers

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints