Risteys · F5_PERSOCHANGE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F62 Cause of death: ICD-10 — F62 2 out of 7 registries used, show all original rules.	149
4. Check minimum number of events None	149
5. Include endpoints None	149
6. Filter based on genotype QC (FinnGen only)	149

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1229	593	625
Only index persons	1114	557	557
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	43.28	42.70	43.81
Only index persons	42.94	42.65	43.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	149	81	68
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	44.93	42.45	47.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1399

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F62.9

ICD-10 Finland

Enduring personality change, unspecified

+∞

57.3

F62.0

ICD-10 Finland

Enduring personality change after catastrophic experience

+∞

45.3

N05AH04

ATC

quetiapine; oral

15.0

40.5

108

F62.8

ICD-10 Finland

Other enduring personality changes

+∞

36.0

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

20.4

33.0

F32.9

ICD-10 Finland

Depressive episode, unspecified

13.0

33.0

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

17.3

29.8

N05AX08

ATC

risperidone; systemic

16.7

28.2

N05AH03

ATC

olanzapine; systemic

22.4

25.3

N06AB04

ATC

citalopram; systemic

8.1

24.8

143

F60.30

ICD-10 Finland

Emotionally unstable personality disorder, impulsive

+∞

24.7

N06AX16

ATC

venlafaxine; oral

8.7

24.3

111

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

15.4

22.5

N06AX11

ATC

mirtazapine; oral

6.0

21.7

279

N05AX12

ATC

aripiprazole; systemic

23.0

21.6

N05AA02

ATC

levomepromazine; systemic

24.0

20.6

T36

ICD-10 Finland

Poisoning by systemic antibiotics

19.5

20.5

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

10.7

20.2

F60.9

ICD-10 Finland

Personality disorder, unspecified

81.6

19.3

F62.1

ICD-10 Finland

Enduring personality change after psychiatric illness

+∞

19.2

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

8.8

18.0

N05AB03

ATC

perphenazine; systemic, rectal

23.1

17.6

N05BA01

ATC

diazepam; systemic, rectal

7.9

17.5

N05CD07

ATC

temazepam; oral

8.6

17.4

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

21.4

17.2

F60.31

ICD-10 Finland

Emotionally unstable personality disorder, borderline condition

+∞

17.0

F61.0

ICD-10 Finland

Mixed personality disorders

+∞

17.0

N06AB03

ATC

fluoxetine; oral

7.3

16.8

N05BA04

ATC

oxazepam; oral

5.3

16.8

181

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

7.9

16.5

N06AB06

ATC

sertraline; oral

7.6

16.0

N05AF03

ATC

chlorprothixene; systemic

27.2

15.6

F29

ICD-10 Finland

Unspecified nonorganic psychosis

15.8

14.9

N03AG01

ATC

valproic acid; systemic, rectal

11.4

14.8

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

13.0

14.8

N05CF01

ATC

zopiclone; oral

4.3

13.9

246

F60.3

ICD-10 Finland

Emotionally unstable personality disorder

154.3

13.7

P29

ICPC

Psychological sympt/compl other

10.2

13.5

N06AX03

ATC

mianserin; oral

15.1

13.5

N06AA09

ATC

amitriptyline; systemic

8.2

13.1

F32.11

ICD-10 Finland

Moderate depressive episode with somatic syndrome

17.7

13.1

N03AX09

ATC

lamotrigine; oral

10.6

12.9

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

8.4

11.7

N03AE01

ATC

clonazepam; systemic

9.4

11.7

F34.1

ICD-10 Finland

Dysthymia

12.7

11.5

ZY010

NOMESCO Finland

Hospital outpatient

9.1

11.5

N03AX16

ATC

pregabalin; oral

4.3

11.4

151

F41.2

ICD-10 Finland

Mixed anxiety and depressive disorder

5.9

11.4

ICB01

NOMESCO Finland

Psychiatric treatment plan, standard

19.8

11.0

N06AX21

ATC

duloxetine; oral

5.8

10.9

N03AX12

ATC

gabapentin; oral

4.8

10.9

104

F43.1

ICD-10 Finland

Post-traumatic stress disorder

15.9

10.8

F60.5

ICD-10 Finland

Anankastic personality disorder

118.5

10.6

F20.9

ICD-10 Finland

Schizophrenia, unspecified

25.7

10.5

P76

ICPC

Depressive disorder

7.4

10.5

IEY05

NOMESCO Finland

Dedicated profession-specific psychiatric intervention, individual

16.2

10.3

N05BA06

ATC

lorazepam; systemic, sublingual

10.8

10.1

N04AA02

ATC

biperiden; systemic

43.4

10.1

N05BE01

ATC

buspirone; oral

22.0

10.0

IGY99

NOMESCO Finland

Other psychiatric treatment contact

22.0

10.0

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

23.7

9.5

Z2446

NOMESCO Finland

Social worker

6.2

9.3

ICZ03

NOMESCO Finland

Participation in compiling a psychiatric treatment plan

17.1

9.2

N05AD01

ATC

haloperidol; systemic

17.1

9.2

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

9.7

9.1

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

20.3

9.1

N05BA12

ATC

alprazolam; oral

5.1

9.0

N06AB05

ATC

paroxetine; oral

7.9

8.9

N06AA12

ATC

doxepin; systemic

9.2

8.9

F32.1

ICD-10 Finland

Moderate depressive episode

6.1

8.8

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

6.1

8.8

F40.1

ICD-10 Finland

Social phobias

17.7

8.7

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

8.8

8.7

F33.30

ICD-10 Finland

Recurrent depression, severe episode without somatic syndrome

29.6

8.6

F61

ICD-10 Finland

Mixed and other personality disorders

+∞

8.4

A01

ICPC

Pain general/multiple sites

6.7

8.4

N06AG02

ATC

moclobemide; oral

9.4

8.1

N03AF01

ATC

carbamazepine; oral, rectal

9.4

8.1

IGY02

NOMESCO Finland

Psychiatric monitoring contact

14.2

8.1

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

5.6

8.0

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

5.4

7.8

ZXY51

NOMESCO Finland

2-person team, doctor-nurse

19.7

7.7

F32.8

ICD-10 Finland

Other depressive episodes

19.7

7.7

A06AD11

ATC

lactulose; oral

4.9

7.7

SPAT1240

SPAT

Therapeutic discussion

4.0

7.7

R51.80

ICD-10 Finland

Headache

3.8

7.7

109

SPAT1260

SPAT

Consultation of another employee

3.6

7.6

122

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.4

7.6

146

R52.2

ICD-10 Finland

Other chronic pain

14.4

7.5

F41.1

ICD-10 Finland

Generalized anxiety disorder

6.3

7.4

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

6.3

7.4

F40.01

ICD-10 Finland

Agoraphobia with concomitant panic disorder

+∞

7.3

F60.8

ICD-10 Finland

Other specific personality disorders

+∞

7.3

F51.0

ICD-10 Finland

Nonorganic insomnia

3.8

7.3

101

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

5.0

7.3

N05AN01

ATC

lithium; oral

13.0

7.2

L03

ICPC

Low back symptom/complaint

3.1

7.2

186

F99

ICD-10 Finland

Mental disorder, not otherwise specified

14.8

7.0

IAA01

NOMESCO Finland

Assessment of need for psychiatric treatment

10.1

7.0

N05AL01

ATC

sulpiride; systemic

23.9

6.8

N05CF02

ATC

zolpidem; oral

3.3

6.7

132

F33.11

ICD-10 Finland

Recurrent depression, moderate episode of somatic syndrome

10.8

6.7

P72

ICPC

Schizophrenia

15.2

6.5

ICC04

NOMESCO Finland

Psychiatric treatment plan, permanent discontinuation

15.2

6.5

3074A

ICD-9 Finland

Special symptoms or syndromes not elsewhere classified, Specific disorders of sleep of nonorganic origin[UNIHÄIRIÖ]

73.0

6.5

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

11.8

6.4

P99

ICPC

Psychological disorders other

11.8

6.4

L28

ICPC

Limited function/disability (L)

3.9

6.4

IGY01

NOMESCO Finland

Accelerated psychiatric treatment contact

19.1

6.3

F31.4

ICD-10 Finland

Bipolar affective disorder, current episode severe depression without psychotic symptoms

19.1

6.3

M54.4

ICD-10 Finland

Lumbago with sciatica

3.3

6.3

114

F60.2

ICD-10 Finland

Dissocial personality disorder

+∞

6.3

M54.5

ICD-10 Finland

Low back pain

2.6

6.3

317

F10.29

ICD-10 Finland

Addiction caused by alcohol UNS

13.3

6.2

N06CA01

ATC

amitriptyline and psycholeptics; systemic

4.1

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERSOCHANGE and mortality.

Females

Parameter	HR [95% CI]	p-value
F5_PERSOCHANGE	3.327 [2.45, 4.53]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.089

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 515 females with F5_PERSOCHANGE died.

Males

Parameter	HR [95% CI]	p-value
F5_PERSOCHANGE	2.806 [2.0, 3.94]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.016

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 545 males with F5_PERSOCHANGE died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSOCHANGE.

N-year risk	Females	Males
1	0.292%	0.583%
5	1.694%	3.167%
10	4.18%	7.849%
15	7.833%	15.454%
20	14.019%	26.046%

Relationships between endpoints

↥

Index endpoint: F5_PERSOCHANGE – Enduring personality changes

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	F5_PERSOCHANGE
CONTROL_EXCLUDE	F5_PERSOBEH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F62
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F62
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Enduring personality changes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints