≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Enduring personality changes

DOID Endpoint Browser PheWeb

F5_PERSOCHANGE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F62
  • Cause of death: ICD-10 — F62

2 out of 7 registries used, show all original rules.

149

4. Check minimum number of events

None

149

5. Include endpoints

None

149

6. Filter based on genotype QC (FinnGen only)

149

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F60-F62
Name in latin
Commutationes personalitatis persistentes non laesioni neque morbo cerebri ascribendae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1229 593 625
Only index persons 1114 557 557
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 43.28 42.70 43.81
Only index persons 42.94 42.65 43.22

-FinnGen-

Key figures

All Female Male
Number of individuals 149 81 68
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 44.93 42.45 47.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
140
Matched controls
1399
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F62.9
ICD-10 Finland
Enduring personality change, unspecified
+∞
57.3
51
*
F62.0
ICD-10 Finland
Enduring personality change after catastrophic experience
+∞
45.3
41
*
N05AH04
ATC
quetiapine; oral
15.0
40.5
78
108
F62.8
ICD-10 Finland
Other enduring personality changes
+∞
36.0
33
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
20.4
33.0
51
38
F32.9
ICD-10 Finland
Depressive episode, unspecified
13.0
33.0
65
87
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
17.3
29.8
49
42
N05AX08
ATC
risperidone; systemic
16.7
28.2
47
41
N05AH03
ATC
olanzapine; systemic
22.4
25.3
37
22
N06AB04
ATC
citalopram; systemic
8.1
24.8
67
143
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
24.7
23
*
N06AX16
ATC
venlafaxine; oral
8.7
24.3
60
111
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
15.4
22.5
38
33
N06AX11
ATC
mirtazapine; oral
6.0
21.7
84
279
N05AX12
ATC
aripiprazole; systemic
23.0
21.6
31
17
N05AA02
ATC
levomepromazine; systemic
24.0
20.6
29
15
T36
ICD-10 Finland
Poisoning by systemic antibiotics
19.5
20.5
31
20
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
10.7
20.2
41
52
F60.9
ICD-10 Finland
Personality disorder, unspecified
81.6
19.3
21
*
F62.1
ICD-10 Finland
Enduring personality change after psychiatric illness
+∞
19.2
18
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.8
18.0
41
63
N05AB03
ATC
perphenazine; systemic, rectal
23.1
17.6
25
13
N05BA01
ATC
diazepam; systemic, rectal
7.9
17.5
43
74
N05CD07
ATC
temazepam; oral
8.6
17.4
40
62
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
21.4
17.2
25
14
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
17.0
16
*
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
17.0
16
*
N06AB03
ATC
fluoxetine; oral
7.3
16.8
44
83
N05BA04
ATC
oxazepam; oral
5.3
16.8
62
181
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
7.9
16.5
40
67
N06AB06
ATC
sertraline; oral
7.6
16.0
40
70
N05AF03
ATC
chlorprothixene; systemic
27.2
15.6
21
9
F29
ICD-10 Finland
Unspecified nonorganic psychosis
15.8
14.9
24
18
N03AG01
ATC
valproic acid; systemic, rectal
11.4
14.8
28
30
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
13.0
14.8
26
24
N05CF01
ATC
zopiclone; oral
4.3
13.9
67
246
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
154.3
13.7
14
*
P29
ICPC
Psychological sympt/compl other
10.2
13.5
27
32
N06AX03
ATC
mianserin; oral
15.1
13.5
22
17
N06AA09
ATC
amitriptyline; systemic
8.2
13.1
30
45
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
17.7
13.1
20
13
N03AX09
ATC
lamotrigine; oral
10.6
12.9
25
28
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
8.4
11.7
26
37
N03AE01
ATC
clonazepam; systemic
9.4
11.7
24
30
F34.1
ICD-10 Finland
Dysthymia
12.7
11.5
20
18
N03AX16
ATC
pregabalin; oral
4.3
11.4
48
151
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
5.9
11.4
33
69
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
19.8
11.0
16
9
N06AX21
ATC
duloxetine; oral
5.8
10.9
32
68
N03AX12
ATC
gabapentin; oral
4.8
10.9
39
104
F43.1
ICD-10 Finland
Post-traumatic stress disorder
15.9
10.8
17
12
F60.5
ICD-10 Finland
Anankastic personality disorder
118.5
10.6
11
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
25.7
10.5
14
6
P76
ICPC
Depressive disorder
7.4
10.5
25
40
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
16.2
10.3
16
11
N05BA06
ATC
lorazepam; systemic, sublingual
10.8
10.1
19
20
N04AA02
ATC
biperiden; systemic
43.4
10.1
12
*
N05BE01
ATC
buspirone; oral
22.0
10.0
14
7
IGY99
NOMESCO Finland
Other psychiatric treatment contact
22.0
10.0
14
7
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
23.7
9.5
13
6
N05AD01
ATC
haloperidol; systemic
17.1
9.2
14
9
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
17.1
9.2
14
9
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
20.3
9.1
13
7
N05BA12
ATC
alprazolam; oral
5.1
9.0
29
68
N06AB05
ATC
paroxetine; oral
7.9
8.9
20
29
N06AA12
ATC
doxepin; systemic
9.2
8.9
18
22
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.1
8.8
24
46
F32.1
ICD-10 Finland
Moderate depressive episode
6.1
8.8
24
46
F40.1
ICD-10 Finland
Social phobias
17.7
8.7
13
8
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
29.6
8.6
11
*
F61
ICD-10 Finland
Mixed and other personality disorders
+∞
8.4
8
*
A01
ICPC
Pain general/multiple sites
6.7
8.4
21
36
N03AF01
ATC
carbamazepine; oral, rectal
9.4
8.1
16
19
N06AG02
ATC
moclobemide; oral
9.4
8.1
16
19
IGY02
NOMESCO Finland
Psychiatric monitoring contact
14.2
8.1
13
10
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.4
7.8
23
49
F32.8
ICD-10 Finland
Other depressive episodes
19.7
7.7
11
6
A06AD11
ATC
lactulose; oral
4.9
7.7
25
59
SPAT1240
SPAT
Therapeutic discussion
4.0
7.7
32
97
R51.80
ICD-10 Finland
Headache
3.8
7.7
34
109
SPAT1260
SPAT
Consultation of another employee
3.6
7.6
36
122
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
7.6
40
146
R52.2
ICD-10 Finland
Other chronic pain
14.4
7.5
12
9
F41.1
ICD-10 Finland
Generalized anxiety disorder
6.3
7.4
19
34
F40.01
ICD-10 Finland
Agoraphobia with concomitant panic disorder
+∞
7.3
7
*
F60.8
ICD-10 Finland
Other specific personality disorders
+∞
7.3
7
*
F51.0
ICD-10 Finland
Nonorganic insomnia
3.8
7.3
32
101
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.0
7.3
23
53
N05AN01
ATC
lithium; oral
13.0
7.2
12
10
L03
ICPC
Low back symptom/complaint
3.1
7.2
45
186
F99
ICD-10 Finland
Mental disorder, not otherwise specified
14.8
7.0
11
8
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
10.1
7.0
13
14
N05AL01
ATC
sulpiride; systemic
23.9
6.8
9
*
N05CF02
ATC
zolpidem; oral
3.3
6.7
36
132
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
10.8
6.7
12
12
P72
ICPC
Schizophrenia
15.2
6.5
10
7
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
15.2
6.5
10
7
3074A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Specific disorders of sleep of nonorganic origin[UNIHÄIRIÖ]
73.0
6.5
7
*
P99
ICPC
Psychological disorders other
11.8
6.4
11
10
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
11.8
6.4
11
10
L28
ICPC
Limited function/disability (L)
3.9
6.4
26
77
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
19.1
6.3
9
5
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
19.1
6.3
9
5
M54.4
ICD-10 Finland
Lumbago with sciatica
3.3
6.3
32
114
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
M54.5
ICD-10 Finland
Low back pain
2.6
6.3
60
317
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
13.3
6.2
10
8
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.1
6.1
23
64

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
28
11.04
22.43
2.3
1.6
—
—
—
0
0
24
40
6.96
14.36
4.0
1.7
—
—
—
0
0
26
53
5.73
12.70
2.6
1.4
—
—
—
0
0
26
63
4.79
10.39
3.2
1.5
—
—
—
0
0
26
66
4.56
9.80
3.3
1.5
—
—
—
0
0
26
67
4.49
9.61
3.2
1.5
—
—
—
0
0
26
67
4.49
9.61
3.3
1.5
—
—
—
0
0
25
68
4.22
8.60
3.4
1.5
—
—
—
0
0
62
310
2.71
7.87
3.5
3.0
7.2
8.3
mmol/l
0.81
50
269
71
388
2.59
7.43
2.0
1.8
99.7
97.1
pmol/l
0.18
45
206
28
92
3.52
7.35
12.0
12.5
93.4
96.5
%
0.67
28
87
28
101
3.18
6.32
12.0
11.5
5.5
5.2
kpa
0.93
28
95
28
101
3.18
6.32
12.0
11.5
10.6
13.1
kpa
1.89
28
96
74
437
2.38
6.28
7.5
6.9
1.2
1.2
mmol/l
0.59
69
410
51
257
2.50
6.13
4.4
3.6
1.0
1.0
kg/l
—
9
32
24
85
3.17
5.56
11.5
13.4
120.0
125.5
g/l
0.66
24
80
45
230
2.37
5.13
2.3
1.9
2.9
2.9
mg/l
0.02
38
198
60
358
2.13
4.65
2.0
3.3
2.3
2.4
mmol/l
0.27
54
319
22
83
2.94
4.56
12.7
7.6
—
—
—
0
0
114
875
2.29
4.47
7.3
7.4
83.5
75.3
u/l
0.89
107
826
9
12
7.90
4.42
14.3
9.6
0.8
0.6
mmol/l
—
9
12
49
278
2.14
4.26
4.3
2.5
—
—
—
0
0
19
70
2.96
4.10
2.4
3.2
66.4
72.1
e9/l
0.40
14
51
5
201
0.22
4.08
1.4
1.3
—
—
—
0
0
7
7
10.41
4.05
1.3
1.0
—
—
—
0
0
86
611
1.96
3.92
6.1
6.3
2.0
1.9
e9/l
0.67
75
549
83
588
1.93
3.76
6.4
6.4
0.0
0.0
e9/l
0.41
72
522
61
390
1.96
3.76
14.6
7.8
1.2
1.1
inr
0.42
22
118
85
608
1.93
3.73
7.1
6.8
0.2
0.2
e9/l
0.18
75
546
17
62
2.97
3.73
5.0
11.8
—
—
—
0
0
12
35
3.64
3.70
1.4
1.2
—
—
—
0
0
67
444
1.92
3.70
4.4
5.1
36.0
36.8
g/l
0.56
62
425
47
276
2.03
3.67
3.1
3.2
1944.4
316.6
mg/l
0.39
26
177
114
906
2.10
3.63
6.1
3.8
14.3
14.5
pmol/l
0.37
109
840
82
588
1.88
3.50
6.3
6.3
0.6
0.6
e9/l
0.67
73
523
48
290
1.97
3.43
3.6
4.0
1.2
8.4
mg/mmol
3.40
29
184
44
259
1.99
3.38
4.6
4.2
—
—
—
0
0
33
176
2.12
3.30
1.9
2.9
2.5
2.4
mmol/l
0.74
27
152
21
96
2.38
3.00
3.1
4.6
—
—
—
0
0
12
41
3.10
2.93
1.9
2.4
—
—
—
0
0
57
381
1.80
2.92
5.0
6.0
—
—
—
0
0
79
582
1.76
2.90
5.6
6.1
29.8
29.0
%
0.26
74
555
78
573
1.76
2.89
5.3
6.0
55.6
56.3
%
0.21
72
548
42
259
1.87
2.77
2.5
1.9
—
—
—
0
0
45
287
1.81
2.66
3.5
4.1
7.4
7.4
ph
—
7
58
66
472
1.72
2.62
4.6
3.1
—
—
—
0
0
41
258
1.81
2.52
3.8
3.3
—
—
—
0
0
39
242
1.83
2.50
1.9
1.8
0.7
0.9
mg/l
0.31
30
182
27
149
1.99
2.45
2.1
2.1
—
—
—
0
0
77
588
1.64
2.30
6.1
6.5
8.8
10.9
umol/l
2.57
70
567
7
18
4.03
2.28
1.4
1.2
—
—
—
0
0
11
42
2.75
2.24
13.8
21.0
—
—
—
0
0
70
526
1.62
2.21
3.5
2.6
88.1
98.7
ug/l
0.19
65
495
130
1152
2.01
2.15
5.4
3.9
6.0
5.8
mmol/l
0.53
124
1081
98
808
1.62
2.05
4.3
3.7
—
—
—
0
0
50
351
1.64
2.04
3.1
2.8
19.4
50.2
e6/l
0.87
38
272
76
591
1.58
2.03
4.1
3.3
0.0
0.0
estimate
0.00
15
112
81
641
1.58
2.00
8.4
5.1
6.7
6.5
mmol/l
0.30
76
589
124
1092
1.81
1.96
6.7
4.7
38.6
38.6
mmol/mol
0.04
119
1036
44
305
1.63
1.87
4.2
3.6
0.0
0.0
estimate
0.00
15
113
5
12
4.27
1.84
2.0
1.3
—
—
—
0
0
75
591
1.54
1.83
5.8
4.6
0.0
0.0
estimate
0.00
15
113
23
133
1.86
1.83
2.1
1.4
—
—
—
0
0
85
689
1.54
1.82
9.1
9.8
4.2
3.9
e9/l
0.59
76
606
7
23
3.14
1.82
1.1
3.0
8.8
8.8
kpa
—
7
23
25
149
1.81
1.81
2.0
1.7
—
—
—
0
0
125
1113
1.76
1.77
6.9
4.3
1.8
1.9
mu/l
0.43
119
1030
9
36
2.59
1.77
1.2
3.1
21.7
20.5
s
—
9
31
6
18
3.43
1.76
1.2
1.1
—
—
—
0
0
29
183
1.73
1.74
3.3
2.9
39.9
128.2
ng/l
0.95
20
123
54
403
1.53
1.66
4.8
3.3
15.1
53.4
ng/l
1.72
35
233
44
314
1.57
1.64
3.2
2.6
0.5
0.3
e6/l
0.25
32
232
75
601
1.50
1.64
4.2
3.4
0.0
0.0
estimate
0.00
14
108
5
14
3.66
1.63
1.2
3.4
—
—
—
0
0
12
58
2.16
1.54
3.2
3.0
0.8
0.7
%
0.75
12
58
5
15
3.41
1.53
4.8
2.5
3.3
2.1
u/ml
—
5
15
66
522
1.47
1.51
10.4
9.2
0.0
0.0
e9/l
0.50
53
421
40
285
1.55
1.50
6.1
6.4
—
—
—
0
0
31
208
1.62
1.49
1.7
1.6
—
—
—
0
0
103
893
1.50
1.45
4.3
3.8
11.3
9.1
mm/h
0.88
98
840
12
60
2.09
1.42
3.2
2.9
2.2
1.0
%
0.85
12
60
16
90
1.87
1.39
1.8
1.7
—
—
—
0
0
21
129
1.73
1.39
1.3
1.6
—
—
—
0
0
6
23
2.67
1.38
1.2
1.4
—
—
—
0
0
53
408
1.46
1.37
4.0
3.2
83.5
37.8
e6/l
0.41
37
290
11
54
2.12
1.36
2.0
1.7
—
3664.8
u/l
—
0
16
0
37
0.00
1.36
0.0
1.5
—
—
—
0
0
24
155
1.65
1.33
1.4
1.3
—
—
—
0
0
9
43
2.16
1.33
8.8
4.6
—
—
—
0
0
8
34
2.43
1.31
1.3
1.1
—
—
—
0
0
5
18
2.84
1.29
1.0
1.2
—
—
—
0
0
14
78
1.88
1.26
3.4
1.7
0.9
1.5
g/l
0.88
14
71
6
26
2.36
1.20
1.3
3.9
—
—
—
0
0
13
72
1.88
1.19
2.0
1.7
23.3
26.1
iu/l
—
7
63
109
1190
0.69
1.16
18.2
12.1
40.3
40.9
%
0.40
77
971
40
515
0.69
1.15
2.7
2.6
—
—
—
0
0
16
98
1.71
1.08
3.6
2.4
11.3
10.2
g/l
0.52
16
86
7
33
2.18
1.07
1.0
1.9
—
—
—
0
0
45
353
1.39
1.02
2.0
2.2
—
—
—
0
0
7
35
2.05
1.01
2.6
16.8
2.1
1.6
%
—
7
30
10
54
1.91
0.99
1.4
2.7
—
—
—
0
0
90
791
1.35
0.98
3.5
3.4
—
—
—
0
0
7
37
1.93
0.95
11.6
8.8
—
—
—
0
0
36
276
1.40
0.93
4.8
3.4
—
—
—
0
0
40
318
1.35
0.83
3.3
2.5
—
—
—
0
0
37
292
1.36
0.80
7.5
5.4
—
—
—
0
0
10
59
1.74
0.78
8.6
6.8
25.9
24.8
mmol/l
—
10
59
7
43
1.66
0.68
1.4
1.3
—
—
—
0
0
28
352
0.75
0.66
1.4
1.4
—
—
—
0
0
12
79
1.56
0.65
2.6
4.5
—
—
—
0
0
5
29
1.75
0.64
5.2
4.4
—
—
—
0
0
46
387
1.27
0.63
3.6
4.1
1.1
1.7
ug/l
1.98
41
346
33
267
1.30
0.61
2.2
1.4
2.3
2.3
g/l
0.04
20
169
8
53
1.54
0.59
2.3
1.8
39.9
36.4
nmol/l
—
8
53
34
279
1.28
0.57
1.4
1.3
0.5
1.6
u/ml
—
8
85
14
100
1.44
0.54
1.2
1.2
—
—
—
0
0
107
1133
0.80
0.53
23.7
14.6
332.9
333.6
g/l
0.29
107
1124
19
146
1.35
0.50
2.3
1.7
—
—
—
0
0
129
1238
1.31
0.48
17.2
11.6
23.4
21.0
mg/l
0.31
105
926
16
208
0.74
0.48
1.3
1.3
1.5
7.7
u/ml
—
6
87
11
78
1.44
0.44
7.6
3.8
—
—
—
0
0
6
92
0.64
0.44
2.0
1.6
—
—
—
0
0
12
87
1.41
0.44
1.6
1.4
—
—
—
0
0
5
32
1.58
0.42
1.0
1.2
—
—
—
0
0
5
35
1.44
0.39
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.2
—
17.6
—
0
19
5
79
0.62
0.36
1.0
1.1
—
—
—
0
0
11
139
0.77
0.28
1.1
1.4
—
—
—
0
0
12
149
0.79
0.27
1.5
1.2
—
—
—
0
0
5
72
0.68
0.26
1.2
1.0
—
—
—
0
0
14
169
0.81
0.25
1.2
1.5
—
—
—
0
0
7
94
0.73
0.23
2.6
2.2
—
19.8
—
0
5
5
40
1.26
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
1.0
—
0
10
39
357
1.13
0.21
3.8
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
10
120
0.82
0.17
1.1
1.4
—
—
—
0
0
10
83
1.22
0.16
1.7
2.1
—
—
—
0
0
10
84
1.20
0.14
2.0
1.2
85.1
187.3
u/ml
—
10
76
5
48
1.04
0.09
1.2
2.1
—
—
—
0
0
6
53
1.14
0.09
5.3
3.3
—
—
—
0
0
8
75
1.07
0.07
1.0
1.1
—
—
—
0
0
8
78
1.03
0.07
1.3
1.2
—
—
—
0
0
22
228
0.96
0.02
2.1
2.4
0.5
0.7
ug/l
1.70
17
125
139
1397
0.93
0.02
26.9
17.3
137.1
137.9
g/l
0.31
139
1381
139
1396
0.94
0.01
26.4
17.2
90.8
90.6
fl
0.20
139
1380
139
1396
0.94
0.01
26.4
17.3
4.6
4.6
e12/l
0.02
134
1365
139
1396
0.94
0.01
26.5
17.3
7.0
6.5
e9/l
2.10
134
1364
22
214
1.03
0.00
1.3
1.3
173.9
26.7
iu/ml
—
5
74
13
126
1.03
0.00
1.2
1.7
—
—
—
0
0
130
1304
0.98
0.00
16.4
10.7
—
—
—
0
0
139
1393
0.97
0.00
26.5
17.3
264.0
251.7
e9/l
1.59
134
1364
139
1395
0.95
0.00
26.4
17.2
30.2
30.3
pg
0.30
139
1378
48
476
1.01
0.00
1.9
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
3.9
3.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
10.5
—
0
6
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
0.7
—
0
5
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERSOCHANGE and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERSOCHANGE 3.327 [2.45, 4.53] < 0.001
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 515 females with F5_PERSOCHANGE died.

Males

Parameter HR [95% CI] p-value
F5_PERSOCHANGE 2.806 [2.0, 3.94] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 545 males with F5_PERSOCHANGE died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSOCHANGE.

N-year risk Females Males
1 0.292% 0.583%
5 1.694% 3.167%
10 4.18% 7.849%
15 7.833% 15.454%
20 14.019% 26.046%

Relationships between endpoints

↥

Index endpoint: F5_PERSOCHANGE – Enduring personality changes

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data