No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
153 |
4. Check minimum number of eventsNone |
153 |
5. Include endpointsNone |
153 |
6. Filter based on genotype QC (FinnGen only) |
147 |
Control definitions (FinnGen only)
- Control exclude
- F5_PERSOBEH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F60-F62
- Name in latin
- Commutationes personalitatis persistentes non laesioni neque morbo cerebri ascribendae
Similar endpoints
↥List of similar endpoints to
Enduring personality changes
based on the number of shared cases.
Similar with more cases:
- Disorders of adult personality and behaviour
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1229 | 593 | 625 |
| Only index persons | 1114 | 557 | 557 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.28 | 42.70 | 43.81 |
| Only index persons | 42.94 | 42.65 | 43.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 147 | 79 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 44.43 | 42.45 | 46.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 153
- Matched controls
- 1530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F62.9
ICD-10 Finland
Enduring personality change, unspecified
+∞
59.3
53
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
18.3
56.9
53
43
N05AH04
ATC
quetiapine; oral
11.2
52.1
88
165
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
14.9
50.9
54
54
N05AX08
ATC
risperidone; systemic
15.6
50.8
52
49
F32.9
ICD-10 Finland
Depressive episode, unspecified
11.6
49.7
69
101
F62.0
ICD-10 Finland
Enduring personality change after catastrophic experience
+∞
47.4
43
*
F62.8
ICD-10 Finland
Other enduring personality changes
+∞
45.0
41
*
N05AX12
ATC
aripiprazole; systemic
20.9
45.0
37
23
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
16.6
44.6
42
34
T36
ICD-10 Finland
Poisoning by systemic antibiotics
20.3
42.2
35
22
N05AH03
ATC
olanzapine; systemic
13.5
40.0
43
43
N06AX16
ATC
venlafaxine; oral
8.8
39.0
69
131
N06AB04
ATC
citalopram; systemic
8.3
37.8
74
156
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
9.1
31.3
46
69
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.5
31.2
50
83
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
8.0
30.0
51
90
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
12.2
27.4
30
30
N06AX11
ATC
mirtazapine; oral
5.9
26.8
96
338
N03AG01
ATC
valproic acid; systemic, rectal
11.2
26.6
31
34
N03AX09
ATC
lamotrigine; oral
11.4
26.2
30
32
N06AB06
ATC
sertraline; oral
7.1
25.3
47
90
N05CD07
ATC
temazepam; oral
7.7
25.1
42
72
N06AB03
ATC
fluoxetine; oral
6.7
24.5
49
101
F60.9
ICD-10 Finland
Personality disorder, unspecified
282.4
24.4
24
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
282.4
24.4
24
*
N05BA01
ATC
diazepam; systemic, rectal
6.7
24.2
48
98
ZY010
NOMESCO Finland
Hospital outpatient
9.8
23.5
30
37
N05AA02
ATC
levomepromazine; systemic
23.0
23.0
33
18
P76
ICPC
Depressive disorder
7.8
22.6
36
58
N03AE01
ATC
clonazepam; systemic
10.0
21.7
27
32
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
27.1
21.3
29
13
F62.1
ICD-10 Finland
Enduring personality change after psychiatric illness
+∞
20.2
19
*
N05AB03
ATC
perphenazine; systemic, rectal
24.9
19.4
27
13
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
5.9
19.4
42
92
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.9
19.0
29
44
P29
ICPC
Psychological sympt/compl other
6.9
18.7
33
59
N06AA09
ATC
amitriptyline; systemic
6.9
18.7
33
59
N05BA04
ATC
oxazepam; oral
4.5
18.4
69
237
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
18.1
17
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
15.3
17.5
29
23
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
17.0
16
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
15.3
16.4
27
21
SPAT1240
SPAT
Therapeutic discussion
5.2
16.0
39
94
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
+∞
15.9
15
*
Z2446
NOMESCO Finland
Social worker
6.8
15.5
27
47
N05BA12
ATC
alprazolam; oral
5.7
15.3
33
71
N05AF03
ATC
chlorprothixene; systemic
21.2
15.2
22
12
N05CF01
ATC
zopiclone; oral
3.9
15.1
73
293
N06AX21
ATC
duloxetine; oral
4.7
14.5
41
111
F34.1
ICD-10 Finland
Dysthymia
12.3
14.4
26
25
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
6.9
14.3
24
40
F43.1
ICD-10 Finland
Post-traumatic stress disorder
14.8
13.9
23
18
N03AX16
ATC
[U] pregabalin
3.8
13.3
55
196
N06AX03
ATC
mianserin; oral
11.2
12.8
24
25
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
14.1
12.6
21
17
F32.1
ICD-10 Finland
Moderate depressive episode
5.3
12.0
27
60
N03AX12
ATC
[U] gabapentin; oral
3.9
11.8
44
145
N05BA06
ATC
lorazepam; systemic, sublingual
11.0
11.7
22
23
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.8
11.5
29
71
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
11.4
49
177
L28
ICPC
Limited function/disability (L)
4.3
11.4
34
95
N05AD01
ATC
haloperidol; systemic
17.2
11.1
17
11
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
30.6
10.9
14
5
F32.8
ICD-10 Finland
Other depressive episodes
23.6
10.9
15
7
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
8.8
10.9
23
30
A01
ICPC
Pain general/multiple sites
4.8
10.7
27
66
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
117.8
10.6
11
*
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
16.1
10.3
16
11
F41.1
ICD-10 Finland
Generalized anxiety disorder
5.1
10.2
23
51
N06AB05
ATC
paroxetine; oral
5.7
10.1
20
39
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
8.4
10.1
22
30
F60.5
ICD-10 Finland
Anankastic personality disorder
43.1
10.1
12
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.4
9.9
20
24
P74
ICPC
Anxiety disorder/anxiety state
5.9
9.9
19
36
N06AX12
ATC
bupropion; oral
4.8
9.8
24
57
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.1
9.7
22
49
IGY02
NOMESCO Finland
Psychiatric monitoring contact
10.6
9.6
18
19
N04AA02
ATC
biperiden; systemic
23.5
9.5
13
6
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
7.9
9.4
21
30
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.3
9.2
26
69
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
9.2
26
69
F20.9
ICD-10 Finland
Schizophrenia, unspecified
13.7
9.1
15
12
F40.1
ICD-10 Finland
Social phobias
13.7
9.1
15
12
IGY99
NOMESCO Finland
Other psychiatric treatment contact
10.5
9.0
17
18
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.4
8.8
24
62
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
11.0
8.8
16
16
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
21.5
8.6
12
6
R53
ICD-10 Finland
Malaise and fatigue
3.0
8.5
51
221
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
11.7
8.5
15
14
F61
ICD-10 Finland
Mixed and other personality disorders
+∞
8.4
8
*
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
12.7
8.3
14
12
N06AB10
ATC
escitalopram; oral
2.9
8.2
51
225
N05AN01
ATC
lithium; oral
9.3
8.0
16
19
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.1
8.0
19
30
N06AA12
ATC
doxepin; systemic
6.6
8.0
20
34
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
8.0
27
82
SPAT1260
SPAT
Consultation of another employee
3.2
7.9
38
145
F99
ICD-10 Finland
Mental disorder, not otherwise specified
12.8
7.7
13
11
A06AD11
ATC
lactulose; oral
3.6
7.7
28
89
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
26.5
7.7
10
*
R02
ICPC
Shortness of breath/dyspnoea
3.8
7.7
26
79
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
8.4
7.6
16
21
L03
ICPC
Low back symptom/complaint
2.7
7.6
55
262
N06AG02
ATC
moclobemide; oral
6.9
7.5
18
29
F60.8
ICD-10 Finland
Other specific personality disorders
84.0
7.5
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.3
7.4
32
114
Z3231
NOMESCO Finland
Registered nurse
2.7
7.4
54
258
M54.5
ICD-10 Finland
Low back pain
2.6
7.4
70
380
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
9.5
7.2
14
16
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
7.6
7.2
16
23
P03
ICPC
Feeling depressed
3.5
7.2
27
88
S06.0
ICD-10 Finland
Concussion
3.6
7.1
25
78
SPAT1307
SPAT
Psychosocial counselling and guidance
4.7
6.9
17
40
U01
ICPC
Dysuria/painful urination
4.7
6.9
17
40
M54.4
ICD-10 Finland
Lumbago with sciatica
2.9
6.9
40
169
ZYC01
NOMESCO Finland
Remote contact by phone
4.4
6.8
18
45
N05AB01
ATC
dixyrazine; systemic
42.0
6.8
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
6.8
70
391
P01
ICPC
Feeling anxious/nervous/tense
3.0
6.8
34
132
C03CA01
ATC
furosemide; systemic
2.8
6.8
41
177
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.7
6.7
16
26
J01FF01
ATC
clindamycin; systemic
2.6
6.7
53
262
N05CF02
ATC
zolpidem; oral
2.8
6.5
38
160
N05BE01
ATC
buspirone; oral
7.1
6.5
15
23
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
8.8
6.5
13
16
F21
ICD-10 Finland
Schizotypal disorder
72.8
6.5
7
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.2
6.5
18
47
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.7
6.4
22
67
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
6.3
39
169
N07BB01
ATC
disulfiram; oral
6.3
6.3
16
28
R52.2
ICD-10 Finland
Other chronic pain
6.8
6.3
15
24
N05AL01
ATC
sulpiride; systemic
19.0
6.3
9
5
N06AA04
ATC
clomipramine; systemic
19.0
6.3
9
5
A02BA02
ATC
ranitidine; systemic
2.9
6.3
34
137
SPAT1219
SPAT
Assessment of need for vocational rehabilitation
+∞
6.3
6
*
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.0
6.3
19
53
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.3
6.3
26
90
Z2445
NOMESCO Finland
Psychologist
5.7
6.2
17
33
SPAT1263
SPAT
Sampling
2.3
6.2
71
412
N03AF01
ATC
carbamazepine; oral, rectal
6.0
6.2
16
29
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.3
6.2
25
85
N02BF02
ATC
pregabalin; oral
4.2
6.2
17
44
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
10.7
6.1
11
11
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
6.0
22
70
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
395
2.55
7.42
2.0
1.8
99.37
97.01
pmol/l
0.16
46
209
77
443
2.49
7.09
7.2
6.9
1.20
1.21
mmol/l
0.57
72
419
81
480
2.46
6.95
7.7
7.6
1.21
1.21
mmol/l
0.25
73
412
53
261
2.58
6.73
4.3
3.5
1.02
1.02
kg/l
—
10
33
21
61
3.83
6.56
1.4
1.4
—
—
—
0
0
28
103
3.10
6.09
12.0
11.4
5.47
5.19
kpa
0.86
28
97
28
103
3.10
6.09
12.0
11.4
10.56
13.05
kpa
1.90
28
98
18
53
3.72
5.50
2.2
2.9
1.46
1.21
mmol/l
—
8
44
46
235
2.37
5.24
2.3
1.9
2.91
2.87
mg/l
0.03
39
202
118
894
2.40
5.00
7.2
7.4
83.13
75.05
u/l
0.91
111
844
35
162
2.50
4.92
1.7
1.8
—
—
—
0
0
61
362
2.14
4.79
2.0
3.3
2.35
2.36
mmol/l
0.25
56
325
27
114
2.66
4.55
1.7
1.5
—
—
—
0
0
27
115
2.64
4.47
1.7
1.6
—
—
—
0
0
118
932
2.16
3.94
5.9
3.8
14.41
14.51
pmol/l
0.16
112
865
50
297
2.02
3.78
3.5
3.7
1.20
8.15
mg/mmol
3.41
30
190
27
125
2.41
3.76
12.8
6.7
105.37
103.90
mmol/l
1.51
27
125
67
451
1.86
3.44
4.4
5.1
36.01
36.85
g/l
0.60
62
433
35
191
2.08
3.28
2.7
1.9
—
—
—
0
0
33
178
2.09
3.19
1.9
2.9
2.46
2.44
mmol/l
0.72
27
154
69
478
1.81
3.17
27.3
11.1
1.20
1.18
inr
0.08
25
146
9
20
4.71
3.16
2.2
2.9
21.89
24.98
mmol/l
—
9
20
32
175
2.05
2.97
2.0
2.5
4.28
2.16
e6/l
0.66
13
97
60
405
1.79
2.96
3.6
2.9
—
—
—
0
0
81
600
1.74
2.88
5.9
6.4
8.93
10.90
umol/l
2.41
73
579
36
211
1.92
2.75
3.0
2.0
—
—
—
0
0
6
10
6.19
2.72
3.0
1.1
—
—
—
0
0
12
43
2.94
2.71
2.2
4.8
23.99
24.09
mmol/l
0.05
12
43
5
160
0.29
2.61
1.4
1.8
—
—
—
0
0
14
58
2.56
2.45
2.9
3.0
0.81
0.71
%
0.67
14
58
134
1179
2.10
2.42
5.4
3.8
6.00
5.79
mmol/l
0.60
128
1107
85
660
1.65
2.38
8.1
5.1
6.68
6.45
mmol/l
0.38
80
606
14
60
2.47
2.29
2.9
2.9
2.24
1.04
%
1.06
14
60
47
317
1.70
2.24
3.1
2.7
0.46
0.32
e6/l
0.24
33
236
79
609
1.61
2.23
4.2
3.3
0.00
0.00
estimate
-0.00
16
120
20
102
2.11
2.22
2.5
2.7
49.62
28.67
u/l
0.32
13
85
39
250
1.75
2.22
1.9
1.8
0.73
0.84
mg/l
0.27
30
189
46
310
1.69
2.19
4.1
3.6
0.00
0.00
estimate
-0.00
15
115
31
188
1.81
2.12
2.1
2.4
0.92
1.03
e6/l
0.08
12
109
13
56
2.44
2.11
1.8
1.7
—
3664.82
u/l
—
0
16
78
605
1.59
2.11
6.1
4.6
0.00
0.00
estimate
-0.00
15
115
5
10
5.13
2.08
1.0
1.4
—
—
—
0
0
57
411
1.62
2.08
4.6
3.3
14.74
55.00
ng/l
1.89
37
238
71
540
1.59
2.08
3.5
2.6
86.93
97.22
ug/l
0.19
66
508
127
1116
1.81
2.04
6.7
4.7
38.80
38.55
mmol/mol
0.11
122
1058
88
706
1.58
2.03
8.8
9.7
4.32
3.91
e9/l
0.68
78
622
129
1142
1.83
1.97
6.8
4.3
1.80
1.86
mu/l
0.31
122
1058
17
86
2.10
1.94
4.0
2.3
90.80
73.28
ml/min/173m2
—
5
36
78
615
1.55
1.90
4.3
3.3
0.00
0.00
estimate
-0.00
14
110
7
22
3.28
1.90
1.0
1.3
—
—
—
0
0
107
917
1.55
1.70
4.2
3.8
11.22
9.05
mm/h
0.94
102
862
29
187
1.68
1.61
3.3
2.9
38.48
212.43
ng/l
1.07
21
124
7
26
2.77
1.60
1.0
1.4
—
—
—
0
0
8
33
2.50
1.56
1.9
1.2
—
—
—
0
0
38
265
1.58
1.55
3.3
2.9
651.14
810.63
ng/l
0.33
33
222
5
15
3.41
1.53
4.8
2.5
3.28
2.11
u/ml
—
5
15
18
103
1.85
1.48
2.4
1.7
—
—
—
0
0
84
961
0.72
1.18
3.2
3.4
—
—
—
0
0
5
20
2.55
1.16
1.0
1.1
—
—
—
0
0
8
40
2.05
1.14
1.1
1.9
—
—
—
0
0
11
59
1.93
1.10
8.0
6.8
25.73
24.84
mmol/l
0.60
11
59
36
267
1.46
1.10
1.9
2.2
—
—
—
0
0
14
82
1.78
1.09
2.5
1.6
—
—
—
0
0
13
75
1.80
1.06
2.0
1.7
23.29
25.76
iu/l
—
7
64
59
485
1.35
1.00
4.8
3.4
—
—
—
0
0
12
70
1.78
0.95
1.5
1.4
—
—
—
0
0
10
56
1.84
0.90
1.4
1.5
—
—
—
0
0
9
57
1.61
0.72
1.1
1.4
—
—
—
0
0
7
41
1.74
0.71
1.6
2.2
—
—
—
0
0
5
27
1.88
0.69
1.6
3.8
193.20
174.78
%
—
5
27
47
393
1.28
0.68
3.6
4.1
1.13
1.66
ug/l
2.05
42
350
11
70
1.62
0.67
1.0
1.7
—
—
—
0
0
125
1178
1.33
0.66
15.3
10.4
92.66
88.51
ml/min/173m2
1.28
102
959
35
284
1.30
0.63
1.4
1.3
0.54
1.84
u/ml
—
8
86
6
35
1.74
0.58
1.2
1.6
—
—
—
0
0
8
54
1.51
0.58
2.3
1.8
39.88
36.65
nmol/l
—
8
54
133
1271
1.36
0.57
16.9
11.5
23.09
21.45
mg/l
0.20
109
953
7
47
1.51
0.48
2.3
1.5
—
—
—
0
0
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
5
31
1.63
0.43
1.4
3.4
91.00
95.42
%
—
5
31
100
938
1.19
0.43
5.3
3.0
46.44
44.63
u/l
0.10
95
903
0
17
0.00
0.41
0.0
1.9
—
13.55
—
0
17
5
35
1.44
0.39
1.2
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
—
—
0
0
35
302
1.21
0.38
1.3
1.6
—
—
—
0
0
37
322
1.20
0.37
1.6
1.7
1.72
1.40
mmol/l
1.19
32
279
15
125
1.22
0.23
13.9
7.1
—
—
—
0
0
117
1203
0.88
0.22
4.2
3.7
1.55
1.28
mmol/l
2.80
112
1123
25
221
1.16
0.22
1.2
1.3
146.75
26.19
iu/ml
—
6
76
0
11
0.00
0.21
0.0
2.1
—
782.18
—
0
11
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
4.2
—
88.19
—
0
14
13
109
1.21
0.19
5.5
2.9
—
—
—
0
0
19
214
0.87
0.17
1.2
1.3
1.40
7.57
u/ml
—
8
89
122
1245
0.90
0.15
4.4
4.0
1.33
1.46
mmol/l
2.71
117
1167
9
81
1.12
0.15
1.1
1.0
—
—
—
0
0
58
559
1.06
0.09
2.2
2.5
—
—
—
0
0
5
48
1.04
0.09
1.6
3.1
—
—
—
0
0
6
56
1.07
0.09
1.2
1.4
—
—
—
0
0
30
313
0.95
0.05
3.7
4.0
17.69
21.63
%
0.87
11
124
22
231
0.94
0.04
2.1
2.4
0.45
0.69
ug/l
1.70
17
125
25
242
1.04
0.02
1.6
1.4
—
—
—
0
0
127
1263
1.03
0.01
4.8
4.3
2.73
2.82
mmol/l
0.55
122
1187
143
1431
0.99
0.00
26.8
17.2
40.68
40.97
%
0.21
133
1375
143
1429
1.01
0.00
26.1
17.2
263.34
252.10
e9/l
1.44
138
1398
143
1433
0.97
0.00
26.5
17.2
137.38
138.01
g/l
0.22
143
1416
143
1432
0.98
0.00
26.0
17.1
4.59
4.58
e12/l
0.13
138
1400
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
162.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
1.0
—
131.80
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_PERSOCHANGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 3.327 [2.45, 4.53] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 515 females with F5_PERSOCHANGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PERSOCHANGE | 2.806 [2.0, 3.94] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 545 males with F5_PERSOCHANGE died.
Mortality risk
Mortality risk for people of age
years, who have F5_PERSOCHANGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.583% |
| 5 | 1.694% | 3.167% |
| 10 | 4.18% | 7.849% |
| 15 | 7.833% | 15.454% |
| 20 | 14.019% | 26.046% |
Relationships between endpoints
↥Index endpoint: F5_PERSOCHANGE – Enduring personality changes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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