Other specified/unspecified disorders of ear

H8_EARNAS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.8, H93.9 Hospital discharge: ICD-9 — 388[8-9] Cause of death: ICD-10 — H93.8, H93.9 Cause of death: ICD-9 — 388[8-9] 2 out of 7 registries used, show all original rules.	102
4. Check minimum number of events None	102
5. Include endpoints None	102
6. Filter based on genotype QC (FinnGen only)	102

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_EARNAS
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H93[8-9]
HD_ICD_9	388[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H93[8-9]
COD_ICD_9	388[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified/unspecified disorders of ear based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	846	451	389
Only index persons	716	406	310
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	46.76	50.76	41.95
Only index persons	48.46	51.62	44.31

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	102	72	30
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	54.87	53.65	57.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
87: Matched controls
868

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H93.9

ICD-10 Finland

Disorder of ear, unspecified

+∞

48.5

H93.8

ICD-10 Finland

Other specified disorders of ear

+∞

34.7

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

114.8

24.1

DFF00

NOMESCO Finland

Pure tone audiometry

59.8

16.8

Z01.1

ICD-10 Finland

Examination of ears and hearing

12.8

13.3

H92.0

ICD-10 Finland

Otalgia

13.7

10.1

UDC00

NOMESCO Finland

Ear microscopy

12.6

8.7

3888X

ICD-9 Finland

Other disorders of ear

+∞

8.5

N07CA01

ATC

betahistine; oral

9.3

7.5

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

7.4

Z46.1

ICD-10 Finland

Fitting and adjustment of hearing aid

29.0

6.3

3889X

ICD-9 Finland

Other disorders of ear, Unspecified disorder of ear

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021589) Normoblasts [#/volume] in Blood

348

2.65

5.47

8.0

8.7

0.0

e9/l

0.00

281

(3013115) Eosinophils [#/volume] in Blood

416

2.66

5.27

4.8

5.9

0.2

e9/l

0.62

373

(3019198) Lymphocytes [#/volume] in Blood

416

2.55

4.88

4.7

5.6

2.0

1.8

e9/l

0.76

374

(3001604) Monocytes [#/volume] in Blood

404

2.46

4.62

4.8

5.6

0.6

e9/l

0.39

354

(3006315) Basophils [#/volume] in Blood

405

2.45

4.58

4.8

5.6

0.0

e9/l

0.98

356

(42870588) Differential panel, method unspecified - Blood

244

2.32

4.03

5.1

5.5

—

(40768795) Lymph node Pathology biopsy report

7.42

3.42

1.0

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

837

3.50

2.92

17.2

13.2

16.2

22.1

mg/l

1.55

643

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

758

2.86

2.90

16.9

12.4

86.5

82.4

ml/min/173m2

0.99

591

(3013650) Neutrophils [#/volume] in Blood by Automated count

475

2.02

2.87

7.3

10.3

4.2

4.1

e9/l

0.15

415

(40758558) Short blood count panel - Blood

214

2.05

2.84

5.2

8.2

—

(40768804) Tissue Pathology biopsy report

362

1.97

2.83

1.9

—

(3044941) Cell count panel - Synovial fluid

8.68

2.78

1.2

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.39

2.65

1.6

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.83

2.30

1.3

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

256

1.85

2.23

2.2

2.1

—

(3044290) Cell count panel - Cerebral spinal fluid

4.48

2.18

1.0

1.7

—

(40768797) Stomach Pathology biopsy report

2.18

1.4

1.3

—

(3002256) Pathology report gross observation

2.13

2.07

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

633

1.88

2.00

4.4

3.9

15.2

14.6

pmol/l

1.28

565

(3037467) Urinalysis macro (dipstick) panel - Urine

581

1.81

1.97

5.2

3.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

163

1.89

1.97

1.9

1.8

0.8

mg/l

0.03

118

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

364

1.73

1.97

5.3

6.8

1.2

mmol/l

1.97

308

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

796

2.33

1.93

4.3

4.2

5.8

5.9

mmol/l

0.21

739

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

737

2.06

1.92

5.6

5.3

39.2

mmol/mol

0.01

695

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

385

1.72

1.91

4.0

3.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

293

1.74

1.91

3.9

3.2

18.2

42.6

ng/l

1.09

190

(3032080) INR in Blood by Coagulation assay

294

1.73

1.89

9.8

5.5

1.4

1.2

inr

0.60

(36304419) Bacteria [Presence] in Urine

224

1.78

1.88

3.6

2.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

762

2.13

1.88

19.8

13.9

39.7

39.5

0.09

582

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.68

1.86

1.2

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.68

1.86

1.2

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

225

1.77

1.85

3.8

3.0

0.3

0.6

e6/l

0.57

157

(3024928) Oxygen saturation in Venous blood

4.32

1.84

1.4

3.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

127

1.93

1.83

3.3

3.0

2.3

3.6

e6/l

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.47

1.77

1.0

1.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

245

1.73

1.77

3.2

2.4

143.5

54.9

u/l

0.54

228

(3018095) Leukocytes [#/volume] in Urine

299

1.69

1.75

4.6

3.5

136.3

58.8

e6/l

0.38

193

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

301

1.67

1.70

1.9

100.8

96.7

pmol/l

0.13

136

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

283

1.68

1.70

3.5

3.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.81

1.61

1.6

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

251

1.67

1.60

3.8

3.0

28.1

49.3

e6/l

0.39

181

(3049717) Cytology report of Urine Cyto stain

2.71

1.54

1.4

1.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.97

1.53

1.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

144

1.77

1.48

4.9

3.5

465.8

129.2

ng/l

0.35

(3052851) Hemolysis interference index of Serum or Plasma

2.61

1.48

2.1

2.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.61

1.48

1.0

1.2

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

3.23

1.45

1.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.13

1.45

1.8

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.52

1.42

1.7

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

188

1.67

1.42

2.3

—

(3042936) Bacteria identified in Isolate by Culture

106

1.85

1.41

2.0

1.8

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

1.37

0.0

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.04

1.37

1.2

1.5

—

(3013512) EKG study

216

1.63

1.36

4.3

3.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

182

1.66

1.34

1.3

1.4

2.7

2.2

g/l

0.56

110

(4035726)

1.95

1.33

1.2

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

141

1.71

1.31

3.3

2.8

0.4

1.2

e6/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

141

1.71

1.31

1.8

1.7

1211.1

1216.9

nmol/l

0.01

113

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

2.87

1.30

1.2

1.3

4.7

3.5

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

573

1.56

1.28

3.4

3.2

—

(3022145) Colonoscopy Study observation

1.87

1.27

1.9

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

607

1.56

1.22

5.1

3.9

11.1

11.4

mm/h

0.08

559

(3026008) Bacteria identified in Urine by Culture

260

1.53

1.16

3.1

2.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

751

1.67

1.15

3.5

3.8

1.3

1.2

mmol/l

0.26

690

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

2.45

1.10

1.4

1.6

15.1

11.1

mg/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.09

1.08

1.9

1.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.20

1.08

1.3

2.1

40.3

46.0

u/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

417

1.45

1.03

5.9

4.7

0.0

estimate

0.00

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

803

1.70

1.02

4.5

4.7

2.8

2.7

mmol/l

0.59

743

(3026493) Urate [Moles/volume] in Serum or Plasma

196

1.51

0.98

2.3

3.1

302.6

6426.7

umol/l

1.01

170

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.70

0.97

4.5

4.3

33.4

33.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

101

0.47

0.95

8.2

5.3

1.1

mmol/l

—

(3000492) Spirometry study

1.78

0.93

1.4

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.66

0.86

2.0

1.6

—

(3045414) Leukocytes [Presence] in Urine

1.99

0.86

2.8

2.3

—

(3035350) Ketones [Presence] in Urine by Test strip

418

1.38

0.84

4.2

3.4

0.0

estimate

0.00

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.64

0.83

2.0

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

212

1.44

0.82

2.5

3.1

851.3

1163.3

ng/l

0.43

181

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.70

0.82

5.2

3.1

—

(3037522) Nuclear Ab [Titer] in Serum

107

1.59

0.82

1.9

1.3

704.0

634.3

titre

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

382

1.37

0.80

3.8

2.7

89.6

86.2

ug/l

0.06

361

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

782

1.52

0.80

4.2

1.5

mmol/l

0.30

721

(3023368) Bacteria identified in Blood by Culture

205

1.43

0.78

6.4

4.2

—

(3009261) Glucose [Presence] in Urine by Test strip

424

1.35

0.75

4.3

3.5

0.0

estimate

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

774

1.48

0.75

5.2

4.7

2.0

1.9

mu/l

0.58

713

(3015736) pH of Urine

328

1.36

0.74

3.4

3.3

—

(3000330) Specific gravity of Urine by Test strip

1.85

0.74

3.3

3.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.61

0.73

26.4

25.6

—

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.67

0.71

2.4

2.2

0.2

g/l

0.53

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.97

0.71

1.6

5.0

24.3

24.4

mmol/l

—

(3022313) Gas panel - Capillary blood

1.97

0.71

1.6

4.9

—

(4010399)

1.71

0.71

1.3

1.5

—

(3018418) pH of Serum or Plasma

237

1.38

0.69

3.7

4.3

7.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.89

0.69

2.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

1.89

0.69

2.0

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

211

1.38

0.66

1.3

1.2

0.6

3.5

u/ml

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

131

1.45

0.65

1.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.76

0.64

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.76

0.64

2.0

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

222

1.36

0.63

3.9

3.0

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.61

0.0

1.7

—

131.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.55

0.60

1.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.66

0.56

9.2

4.8

25.9

25.4

mmol/l

—

(3002385) Erythrocyte distribution width [Ratio]

701

1.33

0.56

22.8

15.8

13.4

13.8

1.66

691

(3022621) pH of Urine by Test strip

1.52

0.55

6.0

2.4

—

(3019225) pH of Specimen

1.42

0.52

3.1

5.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

146

1.37

0.52

1.6

1.2

11.7

30.5

iu/ml

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

790

1.36

0.51

4.1

4.2

4.6

mmol/l

0.09

736

(40761536) Microorganisms panel - Urine sediment

1.52

0.49

3.5

3.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.64

0.45

1.3

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

141

1.34

0.44

1.5

1.2

1.3

4.7

u/ml

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.64

0.43

2.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.64

0.43

2.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.64

0.43

2.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.64

0.43

2.0

1.4

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.1

—

5.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.49

0.41

1.2

2.3

—

(4034850)

0.00

0.40

0.0

11.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.40

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.40

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.45

0.40

2.2

2.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.45

0.40

2.0

1.7

—

(3044889) 12 lead EKG panel

561

1.22

0.39

4.0

3.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

117

1.33

0.38

1.9

2.0

29.4

28.9

0.12

112

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

315

1.22

0.38

4.0

3.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.29

0.37

2.1

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.35

0.34

1.5

1.4

—

(36660697) Celiac disease serology panel - Serum

1.39

0.34

1.1

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.32

0.33

1.3

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.32

0.31

1.9

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.30

0.28

1.8

1.5

—

(40761535) Cells panel - Urine sediment

1.23

0.27

2.9

3.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

180

1.21

0.26

1.7

1.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

152

1.22

0.26

2.2

1.6

381.8

465.0

pmol/l

0.97

133

(3002032) Base excess in Venous blood by calculation

1.22

0.26

3.6

3.1

1.9

2.5

mmol/l

—

(21494755) Public health laboratory ask at order entry panel

1.20

0.25

1.0

1.3

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

0.72

0.25

9.7

6.3

4.5

5.2

kpa

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.72

0.25

2.2

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

229

1.18

0.25

4.2

3.6

0.0

estimate

0.00

(46235355) HIV 1 and 2 tests - Meaningful Use set

182

1.19

0.24

1.6

1.8

—

(3009343) pH of Capillary blood

1.33

0.23

1.6

4.0

—

7.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.26

0.23

1.6

3.9

4.8

4.9

kpa

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

38.2

—

(4281824)

0.00

0.21

0.0

1.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

213

1.17

0.21

4.0

3.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

156

1.19

0.20

1.5

1.7

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.20

0.0

1.7

—

23.4

—

(3003338) MCHC [Mass/volume]

726

0.89

0.17

23.6

17.6

332.0

331.9

g/l

0.02

726

(3017732) Neutrophils [#/volume] in Blood

0.73

0.17

1.8

2.7

4.0

3.8

e9/l

—

(3012544) pH of Venous blood

1.15

0.16

3.7

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.77

0.15

2.0

1.8

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.12

0.10

2.8

2.4

127.0

129.0

g/l

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

155

0.89

0.10

1.6

3.1

2.5

2.4

mmol/l

0.37

135

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.08

0.08

1.7

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

344

1.07

0.08

4.9

4.4

35.9

g/l

0.03

331

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.08

0.07

1.0

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

103

0.86

0.06

1.7

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

169

1.08

0.05

2.2

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

199

1.07

0.05

3.0

4.6

—

(3009508) Creatinine [Moles/volume] in Urine

240

1.06

0.04

2.2

2.9

6.0

7.5

mmol/l

1.46

205

(3020682) Albumin/Creatinine [Ratio] in Urine

229

0.95

0.03

3.8

3.9

2.7

11.1

mg/mmol

—

147

(3003694) ABO and Rh group [Type] in Blood

239

0.95

0.03

1.7

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

113

1.07

0.02

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

102

0.98

0.00

4.7

7.9

—

(3012516) Albumin [Mass/volume] in Urine

218

1.01

0.00

2.3

3.1

16.8

74.2

mg/l

—

143

(3017143) Hepatitis C virus Ab [Presence] in Serum

107

1.03

0.00

1.3

1.5

—

(1761868) Lipid panel - Serum or Plasma

277

1.01

0.00

4.0

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

115

0.95

0.00

2.0

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

11.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.6

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

2.6

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.94

0.00

3.6

2.2

282.3

376.7

nmol/l

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.4

—

16.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.9

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.4

—

6.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

129.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3019060) Gas panel - Arterial blood

0.92

0.00

1.6

3.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

4.4

—

2014.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.02

0.00

1.4

1.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.3

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.97

0.00

1.2

1.3

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.00

0.00

2.1

4.9

9.2

ug/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.98

0.00

1.2

2.4

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

2.0

—

0.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

10.6

—

0.7

—

(4146454)

0.00

0.0

2.6

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.4

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.1

—

(3019977) pH of Arterial blood

0.00

0.0

2.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3000991) Gas panel - Venous blood

0.92

0.00

10.7

7.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

4.2

—

1065.6

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

9.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_EARNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_EARNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_EARNAS – Other specified/unspecified disorders of ear

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of ear

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints