Other specified/unspecified disorders of ear

H8_EARNAS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.8, H93.9 Hospital discharge: ICD-9 — 388[8-9] Cause of death: ICD-10 — H93.8, H93.9 Cause of death: ICD-9 — 388[8-9] 2 out of 7 registries used, show all original rules.	111
4. Check minimum number of events None	111
5. Include endpoints None	111
6. Filter based on genotype QC (FinnGen only)	106

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	H8_EARNAS
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H93[8-9]
HD_ICD_9	388[8-9]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H93[8-9]
COD_ICD_9	388[8-9]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other specified/unspecified disorders of ear based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	846	451	389
Only index persons	716	406	310
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	46.76	50.76	41.95
Only index persons	48.46	51.62	44.31

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	106	74	32
Unadjusted period prevalence (%)	0.02	0.03	0.01
Median age at first event (years)	55.54	53.76	59.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1110

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H93.9

ICD-10 Finland

Disorder of ear, unspecified

+∞

63.8

H93.8

ICD-10 Finland

Other specified disorders of ear

+∞

46.1

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

50.6

25.5

Z01.1

ICD-10 Finland

Examination of ears and hearing

10.5

25.3

DFF00

NOMESCO Finland

Pure tone audiometry

22.6

17.5

H92.0

ICD-10 Finland

Otalgia

9.1

9.7

H93.1

ICD-10 Finland

Tinnitus

33.3

9.6

L01

ICPC

Neck symptom/complaint

4.0

9.1

UDC00

NOMESCO Finland

Ear microscopy

9.1

8.8

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

97.1

8.5

3888X

ICD-9 Finland

Other disorders of ear

+∞

8.4

Z3229

NOMESCO Finland

Other healthcare associate professional

6.9

8.2

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

3.6

8.0

111

K80

ICPC

Cardiac arrhythmia NOS

5.0

7.2

N07CA01

ATC

betahistine; oral

6.1

6.8

3889X

ICD-9 Finland

Other disorders of ear, Unspecified disorder of ear

+∞

6.3

L03

ICPC

Low back symptom/complaint

2.8

6.2

203

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013115) Eosinophils [#/volume] in Blood

463

2.58

5.35

5.2

5.9

0.20

0.17

e9/l

0.61

417

(3021589) Normoblasts [#/volume] in Blood

381

2.51

5.33

8.2

8.4

0.00

e9/l

-0.00

306

(3019198) Lymphocytes [#/volume] in Blood

466

2.45

4.86

5.1

5.5

2.04

1.86

e9/l

0.94

424

(3006315) Basophils [#/volume] in Blood

450

2.41

4.75

5.2

5.5

0.03

0.04

e9/l

0.86

398

(3001604) Monocytes [#/volume] in Blood

451

2.40

4.72

5.2

5.5

0.57

0.55

e9/l

0.32

399

(3044941) Cell count panel - Synovial fluid

8.20

3.61

3.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.58

3.47

1.7

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

418

2.02

3.26

5.3

5.9

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.65

3.25

2.8

1.0

—

(40768795) Lymph node Pathology biopsy report

6.70

3.23

1.0

1.1

—

(3021788) Differential panel - Synovial fluid

7.84

3.09

3.0

1.3

—

(40758558) Short blood count panel - Blood

233

2.04

3.01

5.6

7.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

523

1.99

2.99

7.5

9.8

4.18

4.04

e9/l

0.19

456

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

104

912

3.22

2.92

17.9

12.9

15.87

22.36

mg/l

1.87

697

(40768804) Tissue Pathology biopsy report

398

1.89

2.74

2.1

1.9

—

(3030467) Casts [#/volume] in Urine by Automated count

234

1.95

2.65

4.2

3.0

0.31

0.54

e6/l

0.57

162

(40768797) Stomach Pathology biopsy report

104

2.26

2.57

1.4

1.3

—

(40761511) CBC panel - Blood by Automated count

105

937

3.23

2.56

15.8

11.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.59

2.52

1.1

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.59

2.52

1.1

1.4

—

(3018095) Leukocytes [#/volume] in Urine

317

1.84

2.45

5.6

3.5

124.57

60.45

e6/l

0.34

205

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

137

2.06

2.38

3.6

2.8

3.00

3.40

e6/l

0.11

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

321

1.81

2.33

1.9

2.0

98.31

97.70

pmol/l

0.02

152

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.66

2.32

1.6

2.0

14.74

11.28

mg/l

—

(36304419) Bacteria [Presence] in Urine

235

1.86

2.31

3.8

2.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.08

2.29

1.3

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

263

1.81

2.23

4.6

3.0

26.13

48.51

e6/l

0.45

190

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

298

1.79

2.23

3.9

3.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

464

1.76

2.23

6.3

6.9

13.40

10.97

umol/l

0.53

438

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

836

2.27

2.21

18.3

11.9

86.00

83.25

ml/min/173m2

0.51

657

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.87

2.13

2.9

2.3

39.20

46.39

u/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

629

1.81

2.12

5.5

3.9

—

(3024928) Oxygen saturation in Venous blood

4.16

2.07

14.3

2.9

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

4.16

2.07

2.7

11.7

—

139.80

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

262

1.75

2.00

3.3

2.5

134.41

54.70

u/l

0.53

242

(3044290) Cell count panel - Cerebral spinal fluid

3.90

1.96

1.0

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

399

1.69

1.95

9.8

7.0

1.23

1.21

mmol/l

1.50

343

(3044640) Blood type and Crossmatch panel - Blood

281

1.73

1.95

2.4

2.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

3.67

1.86

1.3

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

150

1.86

1.83

3.6

2.7

0.35

1.15

e6/l

2.46

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

183

1.79

1.82

1.9

1.8

0.97

0.88

mg/l

0.12

132

(3007164) IgA [Mass/volume] in Serum or Plasma

200

1.76

1.80

1.5

1.4

2.61

2.19

g/l

0.54

125

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

159

1.83

1.80

4.8

3.5

441.96

335.25

ng/l

0.09

109

(3034770) Mitochondria Ab [Titer] in Serum

2.92

1.68

1.0

1.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

374

1.61

1.66

17.6

10.6

1.30

1.18

inr

0.42

115

(3002256) Pathology report gross observation

108

1.92

1.63

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.69

1.63

1.4

—

(3042936) Bacteria identified in Isolate by Culture

116

1.88

1.62

2.3

1.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

148

1.79

1.61

1.7

1269.53

1168.81

nmol/l

0.23

120

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.80

1.61

1.6

1.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

864

1.97

1.58

4.2

5.78

5.87

mmol/l

0.28

802

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

1.56

0.0

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

698

1.67

1.55

4.3

3.9

15.23

14.60

pmol/l

1.42

627

(3049717) Cytology report of Urine Cyto stain

2.70

1.54

1.4

2.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.96

1.52

1.0

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

419

1.56

1.50

2.8

2.4

—

(3052851) Hemolysis interference index of Serum or Plasma

2.51

1.41

2.1

2.4

—

(3037522) Nuclear Ab [Titer] in Serum

123

1.76

1.35

1.8

1.3

704.00

607.27

titre

—

(4035726) Immunohistochemistry procedure

1.91

1.35

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

315

1.54

1.32

3.9

3.1

18.20

41.38

ng/l

1.09

202

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

208

1.61

1.32

2.5

2.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

809

1.69

1.30

6.1

5.2

39.56

38.98

mmol/mol

0.22

765

(3023511) Choriogonadotropin [Units/volume] in Urine

2.86

1.30

1.2

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.01

1.28

1.8

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

449

1.50

1.28

6.1

4.7

0.00

estimate

-0.00

(3026008) Bacteria identified in Urine by Culture

282

1.53

1.24

3.2

2.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

631

1.52

1.24

3.4

3.2

—

(3022145) Colonoscopy Study observation

1.84

1.22

1.9

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

453

1.48

1.20

4.2

3.4

0.00

estimate

-0.00

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.88

1.16

2.3

0.20

0.23

g/l

0.53

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

2.57

1.16

1.2

1.3

4.66

3.54

mmol/l

—

(3013512) EKG study

232

1.53

1.16

4.3

3.4

—

(3000492) Spirometry study

1.83

1.15

1.4

1.6

—

(3000330) Specific gravity of Urine by Test strip

2.08

1.14

3.3

3.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.42

1.14

1.0

1.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.42

1.14

1.6

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

215

1.54

1.14

3.1

3.0

319.48

5814.42

umol/l

1.01

189

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

876

1.71

1.11

4.6

2.78

2.72

mmol/l

0.22

814

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

226

1.52

1.09

2.4

3.1

986.06

1128.09

ng/l

0.18

194

(3013707) Erythrocyte sedimentation rate by Westergren method

661

1.47

1.08

5.5

3.9

11.09

11.39

mm/h

0.08

611

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.19

1.07

1.7

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

822

1.59

1.07

3.6

3.8

1.30

1.25

mmol/l

0.19

759

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.99

1.05

1.9

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

416

1.42

1.00

4.1

2.7

97.01

90.25

ug/l

0.12

392

(3045414) Leukocytes [Presence] in Urine

2.01

0.99

2.9

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.69

0.96

1.9

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

458

1.40

0.95

4.3

3.4

0.00

estimate

—

(3023368) Bacteria identified in Blood by Culture

215

1.47

0.94

6.2

4.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

233

1.46

0.94

1.3

1.2

0.56

3.24

u/ml

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.67

0.93

1.9

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

854

1.55

0.90

4.3

4.1

1.47

1.50

mmol/l

0.25

792

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

138

1.55

0.89

1.8

—

(4200892) Spirometry reversibility

1.77

0.86

1.3

1.5

—

(3022313) Gas panel - Capillary blood

1.99

0.86

1.8

4.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.66

0.82

4.9

3.0

—

(3022621) pH of Urine by Test strip

1.71

0.78

6.0

2.3

—

(3000494) Fungus identified in Specimen by Culture

100

1.58

0.77

2.0

1.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

100

1.58

0.77

4.5

4.3

35.67

33.44

—

(3018418) pH of Serum or Plasma

260

1.38

0.77

6.7

4.2

7.39

7.40

—

(3014051) Protein [Presence] in Urine by Test strip

2.13

0.75

3.6

2.0

—

(36660697) Celiac disease serology panel - Serum

1.63

0.72

1.1

1.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.97

0.71

1.0

2.9

255.80

170.04

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.75

0.71

1.1

2.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

310

1.34

0.71

3.3

3.6

2.38

2.35

mmol/l

0.83

279

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.67

0.68

9.1

4.4

25.74

25.35

mmol/l

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.82

0.67

2.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

1.82

0.67

2.0

1.4

—

(3009343) pH of Capillary blood

1.63

0.66

1.7

3.8

—

7.43

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.61

0.0

1.8

—

131.50

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.61

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.61

0.0

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

223

1.34

0.60

4.2

3.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

862

1.39

0.60

4.2

4.57

4.65

mmol/l

0.36

807

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

161

1.38

0.57

1.9

1.2

11.21

29.52

iu/ml

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

108

0.62

0.51

19.6

6.2

1.16

1.11

mmol/l

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

110

0.61

0.51

1.4

1.3

1.44

1.38

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

849

1.32

0.48

5.2

4.6

1.99

1.85

mu/l

0.57

785

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.49

0.48

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

157

1.33

0.47

1.6

1.2

1.28

5.66

u/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

203

1.30

0.47

2.0

1.9

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.64

0.43

2.0

1.5

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.64

0.43

1.6

4.6

24.34

24.32

mmol/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

1.2

1.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.64

0.43

1.2

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.59

0.43

1.0

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.59

0.43

2.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.59

0.43

2.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.59

0.43

2.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.59

0.43

2.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

244

1.26

0.42

3.8

2.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.38

0.42

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.1

—

4.99

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.36

0.41

1.8

1.6

—

(3019225) pH of Specimen

1.45

0.41

6.7

4.9

—

(4034850) Laboratory test

0.00

0.40

0.0

10.8

—

(40761535) Cells panel - Urine sediment

1.33

0.38

3.4

3.3

—

(40761536) Microorganisms panel - Urine sediment

1.43

0.38

3.5

3.1

—

(3002032) Base excess in Venous blood by calculation

1.40

0.38

13.2

3.5

1.95

2.46

mmol/l

0.24

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

154

1.28

0.37

2.1

1.6

381.75

462.47

pmol/l

0.94

135

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

0.67

0.34

9.7

6.5

4.55

5.13

kpa

—

(3044889) 12 lead EKG panel

605

1.18

0.33

3.9

3.5

—

(3012544) pH of Venous blood

1.34

0.31

13.3

3.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

343

1.16

0.27

3.8

3.5

—

(3017732) Neutrophils [#/volume] in Blood

0.66

0.27

1.8

2.5

3.97

3.67

e9/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.20

0.25

2.4

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.31

0.25

2.0

1.6

—

(40768443) Skin Pathology biopsy report

1.33

0.23

1.4

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.33

0.23

2.0

1.6

—

(3008898) HLA-B27 [Presence]

1.33

0.23

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.74

0.23

2.0

1.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.30

0.23

17.0

2.2

0.56

0.67

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.30

0.23

1.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

173

1.19

0.23

2.0

1.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.23

0.22

17.0

2.2

0.70

1.17

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

101

0.78

0.22

2.0

1.8

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

35.06

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

2.7

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.21

0.0

1.7

—

7.99

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(3002385) Erythrocyte distribution width [Ratio]

790

1.15

0.21

24.4

15.2

13.85

14.91

1.75

780

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.26

0.20

15.3

3.3

119.67

129.29

g/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.26

0.20

1.5

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

194

1.17

0.20

1.7

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.22

0.18

1.3

2.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

120

0.82

0.17

1.7

1.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.76

0.17

1.4

1.3

—

(3000991) Gas panel - Venous blood

1.12

0.16

21.4

7.0

—

(3003338) MCHC [Mass/volume]

795

0.90

0.16

25.6

17.2

331.53

331.99

g/l

0.19

795

(3003694) ABO and Rh group [Type] in Blood

261

0.90

0.13

1.7

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

250

1.11

0.12

4.1

3.6

0.00

estimate

-0.00

(3009508) Creatinine [Moles/volume] in Urine

262

1.09

0.10

3.4

2.9

5.82

7.55

mmol/l

2.13

228

(3001019) Free T4 and TSH panel - Serum or Plasma

1.17

0.10

2.2

1.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

133

0.89

0.08

2.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.09

0.07

2.1

2.2

4.38

9.18

ug/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

193

0.92

0.07

2.2

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

111

0.89

0.06

4.7

7.4

—

(3012516) Albumin [Mass/volume] in Urine

238

1.07

0.05

3.6

3.1

14.18

72.08

mg/l

2.23

156

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

1.08

0.04

2.1

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

121

1.08

0.04

1.5

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.10

0.03

16.4

6.2

102.00

103.88

mmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

248

1.01

0.00

4.4

3.7

2.41

10.83

mg/mmol

2.01

161

(1761868) Lipid panel - Serum or Plasma

303

0.99

0.00

3.8

2.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

105

1.05

0.00

2.0

2.7

0.44

0.74

ug/l

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.4

—

2014.80

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.7

—

129.67

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

5.83

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.88

-0.00

1.2

1.4

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.3

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

-0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.92

-0.00

1.0

1.6

—

(3019060) Gas panel - Arterial blood

0.90

-0.00

1.6

3.7

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(21494755) Public health laboratory ask at order entry panel

1.01

-0.00

1.0

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.99

-0.00

3.3

2.1

272.50

386.47

nmol/l

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.7

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.2

—

1065.60

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.86

-0.00

1.8

1.5

—

(3019977) pH of Arterial blood

0.00

-0.00

0.0

2.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

10.6

—

0.71

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

11.01

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

6.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3010503) CD19 cells [#/volume] in Blood

0.00

-0.00

0.0

1.8

—

0.17

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

2.6

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

32.08

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.1

—

8.54

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

2.5

—

16.18

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_EARNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_EARNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_EARNAS – Other specified/unspecified disorders of ear

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other specified/unspecified disorders of ear

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints