Other specified/unspecified disorders of ear

H8_EARNAS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H93.8, H93.9
  • Hospital discharge: ICD-9 388[8-9]
  • Cause of death: ICD-10 H93.8, H93.9
  • Cause of death: ICD-9 388[8-9]

2 out of 7 registries used, show all original rules.

102

4. Check minimum number of events

None

102

5. Include endpoints

None

102

6. Filter based on genotype QC (FinnGen only)

102

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 846 451 389
Only index persons 716 406 310
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 46.76 50.76 41.95
Only index persons 48.46 51.62 44.31

-FinnGen-

Key figures

All Female Male
Number of individuals 102 72 30
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 54.87 53.65 57.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
87
Matched controls
868
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H93.9
ICD-10 Finland
Disorder of ear, unspecified
+∞
48.5
42
*
H93.8
ICD-10 Finland
Other specified disorders of ear
+∞
34.7
31
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
114.8
24.1
25
*
DFF00
NOMESCO Finland
Pure tone audiometry
59.8
16.8
19
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
12.8
13.3
24
25
H92.0
ICD-10 Finland
Otalgia
13.7
10.1
17
15
UDC00
NOMESCO Finland
Ear microscopy
12.6
8.7
15
14
3888X
ICD-9 Finland
Other disorders of ear
+∞
8.5
8
*
N07CA01
ATC
betahistine; oral
9.3
7.5
15
19
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
7.4
7
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
29.0
6.3
8
*
3889X
ICD-9 Finland
Other disorders of ear, Unspecified disorder of ear
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
348
2.65
5.47
8.0
8.7
0.0
0.0
e9/l
0.00
46
281
66
416
2.66
5.27
4.8
5.9
0.2
0.2
e9/l
0.62
56
373
65
416
2.55
4.88
4.7
5.6
2.0
1.8
e9/l
0.76
57
374
63
404
2.46
4.62
4.8
5.6
0.6
0.6
e9/l
0.39
54
354
63
405
2.45
4.58
4.8
5.6
0.0
0.0
e9/l
0.98
53
356
43
244
2.32
4.03
5.1
5.5
—
—
—
0
0
7
10
7.42
3.42
1.0
1.1
—
—
—
0
0
96
837
3.50
2.92
17.2
13.2
16.2
22.1
mg/l
1.55
83
643
65
475
2.02
2.87
7.3
10.3
4.2
4.1
e9/l
0.15
56
415
36
214
2.05
2.84
5.2
8.2
—
—
—
0
0
53
362
1.97
2.83
1.9
1.9
—
—
—
0
0
5
6
8.68
2.78
1.2
1.3
—
—
—
0
0
19
89
2.39
2.65
1.6
1.5
—
—
—
0
0
39
256
1.85
2.23
2.2
2.1
—
—
—
0
0
6
14
4.48
2.18
1.0
1.7
—
—
—
0
0
19
97
2.18
2.18
1.4
1.3
—
—
—
0
0
19
99
2.13
2.07
1.2
1.2
—
—
—
0
0
77
633
1.88
2.00
4.4
3.9
15.2
14.6
pmol/l
1.28
66
565
72
581
1.81
1.97
5.2
3.9
—
—
—
0
0
27
163
1.89
1.97
1.9
1.8
0.8
0.8
mg/l
0.03
19
118
91
796
2.33
1.93
4.3
4.2
5.8
5.9
mmol/l
0.21
79
739
86
737
2.06
1.92
5.6
5.3
39.2
39.2
mmol/mol
0.01
76
695
42
293
1.74
1.91
3.9
3.2
18.2
42.6
ng/l
1.09
25
190
42
294
1.73
1.89
9.8
5.5
1.4
1.2
inr
0.60
13
86
34
224
1.78
1.88
3.6
2.8
—
—
—
0
0
88
762
2.13
1.88
19.8
13.9
39.7
39.5
%
0.09
62
582
34
225
1.77
1.85
3.8
3.0
0.3
0.6
e6/l
0.57
26
157
5
12
4.32
1.84
1.4
3.1
—
—
—
0
0
36
245
1.73
1.77
3.2
2.4
143.5
54.9
u/l
0.54
31
228
42
299
1.69
1.75
4.6
3.5
136.3
58.8
e6/l
0.38
31
193
42
301
1.67
1.70
1.9
1.9
100.8
96.7
pmol/l
0.13
19
136
36
251
1.67
1.60
3.8
3.0
28.1
49.3
e6/l
0.39
28
181
7
27
2.71
1.54
1.4
1.9
—
—
—
0
0
6
21
2.97
1.53
1.7
1.7
—
—
—
0
0
23
144
1.77
1.48
4.9
3.5
465.8
129.2
ng/l
0.35
18
98
7
28
2.61
1.48
2.1
2.6
—
—
—
0
0
7
28
2.61
1.48
1.0
1.2
—
—
—
0
0
5
16
3.23
1.45
1.0
1.3
—
—
—
0
0
18
106
1.85
1.41
2.0
1.8
—
—
—
0
0
31
216
1.63
1.36
4.3
3.6
—
—
—
0
0
27
182
1.66
1.34
1.3
1.4
2.7
2.2
g/l
0.56
16
110
14
77
1.95
1.33
1.2
1.3
—
—
—
0
0
22
141
1.71
1.31
1.8
1.7
1211.1
1216.9
nmol/l
0.01
16
113
5
18
2.87
1.30
1.2
1.3
4.7
3.5
mmol/l
—
5
18
15
86
1.87
1.27
1.9
1.2
—
—
—
0
0
71
607
1.56
1.22
5.1
3.9
11.1
11.4
mm/h
0.08
65
559
35
260
1.53
1.16
3.1
2.7
—
—
—
0
0
84
751
1.67
1.15
3.5
3.8
1.3
1.2
mmol/l
0.26
75
690
5
21
2.45
1.10
1.4
1.6
15.1
11.1
mg/l
—
5
21
51
417
1.45
1.03
5.9
4.7
0.0
0.0
estimate
0.00
12
75
88
803
1.70
1.02
4.5
4.7
2.8
2.7
mmol/l
0.59
78
743
27
196
1.51
0.98
2.3
3.1
302.6
6426.7
umol/l
1.01
20
170
5
101
0.47
0.95
8.2
5.3
1.1
1.1
mmol/l
—
5
91
12
71
1.78
0.93
1.4
1.5
—
—
—
0
0
6
31
1.99
0.86
2.8
2.3
—
—
—
0
0
50
418
1.38
0.84
4.2
3.4
0.0
0.0
estimate
0.00
11
74
16
107
1.59
0.82
1.9
1.3
704.0
634.3
titre
—
5
28
46
382
1.37
0.80
3.8
2.7
89.6
86.2
ug/l
0.06
41
361
85
782
1.52
0.80
4.2
4.2
1.5
1.5
mmol/l
0.30
76
721
27
205
1.43
0.78
6.4
4.2
—
—
—
0
0
50
424
1.35
0.75
4.3
3.5
0.0
0.0
estimate
—
9
69
84
774
1.48
0.75
5.2
4.7
2.0
1.9
mu/l
0.58
73
713
40
328
1.36
0.74
3.4
3.3
—
—
—
0
0
7
39
1.85
0.74
3.3
3.8
—
—
—
0
0
13
85
1.61
0.73
26.4
25.6
—
1.2
—
0
18
11
69
1.67
0.71
2.4
2.2
0.2
0.2
g/l
0.53
11
64
5
26
1.97
0.71
1.6
5.0
24.3
24.4
mmol/l
—
5
26
5
26
1.97
0.71
1.6
4.9
—
—
—
0
0
10
61
1.71
0.71
1.3
1.5
—
—
—
0
0
30
237
1.38
0.69
3.7
4.3
7.4
7.4
ph
—
6
43
5
27
1.89
0.69
2.0
1.4
—
—
—
0
0
5
27
1.89
0.69
2.0
1.4
—
—
—
0
0
27
211
1.38
0.66
1.3
1.2
0.6
3.5
u/ml
—
5
53
5
29
1.76
0.64
2.0
1.6
—
—
—
0
0
28
222
1.36
0.63
3.9
3.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.7
—
131.5
—
0
12
6
37
1.66
0.56
9.2
4.8
25.9
25.4
mmol/l
—
6
37
76
701
1.33
0.56
22.8
15.8
13.4
13.8
%
1.66
76
691
9
61
1.52
0.55
6.0
2.4
—
—
—
0
0
9
65
1.42
0.52
3.1
5.0
—
—
—
0
0
19
146
1.37
0.52
1.6
1.2
11.7
30.5
iu/ml
—
7
56
84
790
1.36
0.51
4.1
4.2
4.6
4.6
mmol/l
0.09
76
736
10
68
1.52
0.49
3.5
3.2
—
—
—
0
0
18
141
1.34
0.44
1.5
1.2
1.3
4.7
u/ml
—
6
55
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
11.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
5
35
1.45
0.40
2.2
2.0
—
—
—
0
0
61
561
1.22
0.39
4.0
3.6
—
—
—
0
0
15
117
1.33
0.38
1.9
2.0
29.4
28.9
s
0.12
15
112
10
74
1.39
0.34
1.1
1.2
—
—
—
0
0
6
46
1.32
0.33
1.3
1.2
—
—
—
0
0
12
95
1.30
0.28
1.8
1.5
—
—
—
0
0
8
66
1.23
0.27
2.9
3.3
—
—
—
0
0
18
152
1.22
0.26
2.2
1.6
381.8
465.0
pmol/l
0.97
12
133
9
75
1.22
0.26
3.6
3.1
1.9
2.5
mmol/l
—
9
55
9
76
1.20
0.25
1.0
1.3
—
—
—
0
0
6
82
0.72
0.25
9.7
6.3
4.5
5.2
kpa
—
6
77
26
229
1.18
0.25
4.2
3.6
0.0
0.0
estimate
0.00
11
69
21
182
1.19
0.24
1.6
1.8
—
—
—
0
0
5
38
1.33
0.23
1.6
4.0
—
7.4
—
0
5
5
40
1.26
0.23
1.6
3.9
4.8
4.9
kpa
—
5
34
0
10
0.00
0.21
0.0
1.3
—
38.2
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
24
213
1.17
0.21
4.0
3.4
—
—
—
0
0
18
156
1.19
0.20
1.5
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
23.4
—
0
8
70
726
0.89
0.17
23.6
17.6
332.0
331.9
g/l
0.02
70
726
5
67
0.73
0.17
1.8
2.7
4.0
3.8
e9/l
—
5
57
9
79
1.15
0.16
3.7
3.0
—
—
—
0
0
7
89
0.77
0.15
2.0
1.8
—
—
—
0
0
5
45
1.12
0.10
2.8
2.4
127.0
129.0
g/l
—
5
45
14
155
0.89
0.10
1.6
3.1
2.5
2.4
mmol/l
0.37
14
135
36
344
1.07
0.08
4.9
4.4
35.9
35.9
g/l
0.03
36
331
9
84
1.08
0.07
1.0
1.6
—
—
—
0
0
21
199
1.07
0.05
3.0
4.6
—
—
—
0
0
25
240
1.06
0.04
2.2
2.9
6.0
7.5
mmol/l
1.46
18
205
22
229
0.95
0.03
3.8
3.9
2.7
11.1
mg/mmol
—
10
147
23
239
0.95
0.03
1.7
1.5
—
—
—
0
0
12
113
1.07
0.02
1.6
1.6
—
—
—
0
0
22
218
1.01
0.00
2.3
3.1
16.8
74.2
mg/l
—
10
143
11
107
1.03
0.00
1.3
1.5
—
—
—
0
0
28
277
1.01
0.00
4.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
11.0
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
7
74
0.94
0.00
3.6
2.2
282.3
376.7
nmol/l
—
7
66
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
6.1
—
0
5
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
5
54
0.92
0.00
1.6
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
2014.8
—
0
5
7
69
1.02
0.00
1.4
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
2.1
2.1
4.9
9.2
ug/l
—
7
64
5
51
0.98
0.00
1.2
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
0.2
—
0
5
0
7
0.00
0.00
0.0
10.6
—
0.7
—
0
7
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
6
65
0.92
0.00
10.7
7.3
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
1065.6
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_EARNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_EARNAS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_EARNAS – Other specified/unspecified disorders of ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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