No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
123 |
4. Check minimum number of eventsNone |
123 |
5. Include endpointsNone |
123 |
6. Filter based on genotype QC (FinnGen only) |
123 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L95
- Name in latin
- Vasculitis lividoides
Similar endpoints
↥List of similar endpoints to
Livedoid vasculitis
based on the number of shared cases.
Similar with more cases:
- Vasculitis limited to skin, not elsewhere classified
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 736 | 442 | 289 |
| Only index persons | 645 | 394 | 251 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 62.30 | 64.34 | 59.28 |
| Only index persons | 60.70 | 62.60 | 57.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 123 | 73 | 50 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 61.66 | 62.75 | 60.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1109
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L95.0
ICD-10 Finland
Livedoid vasculitis
+∞
160.1
111
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
48.5
43
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
628.1
44.5
41
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
22.5
34.6
53
43
L95.8
ICD-10 Finland
Other vasculitis limited to skin
+∞
34.1
31
*
S97
ICPC
Chronic ulcer skin
27.3
26.1
36
19
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
302.4
24.7
24
*
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
47.6
19.4
23
6
H02AB06
ATC
prednisolone; systemic
7.2
19.3
87
372
D69.0
ICD-10 Finland
Allergic purpura
212.3
18.1
18
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
20.8
17.6
26
16
L04AX01
ATC
azathioprine; systemic
19.5
17.2
26
17
A46
ICD-10 Finland
Erysipelas
7.5
16.0
42
83
J01FF01
ATC
clindamycin; systemic
5.4
14.9
58
186
J01MA02
ATC
ciprofloxacin; systemic
5.0
14.3
71
289
ZZA00
NOMESCO Finland
Split skin graft
26.4
13.4
18
8
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
145.7
12.7
13
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
9.6
11.6
24
31
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.4
11.0
36
90
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
10.5
10.9
21
24
C03CA01
ATC
furosemide; systemic
4.0
10.4
55
219
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
10.0
60
262
E0000UV
ATC
NA
3.7
9.8
62
283
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
33.2
9.6
12
*
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
5.6
9.0
27
60
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
8.8
70
371
N02AX02
ATC
tramadol; systemic, rectal
3.4
8.8
65
325
H02AB07
ATC
prednisone; oral
4.7
8.6
31
84
D07AC01
ATC
betamethasone; topical
3.4
8.4
55
249
D07AD01
ATC
clobetasol; topical
4.4
8.4
33
98
J01CF05
ATC
flucloxacillin; systemic
13.1
8.3
14
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
8.3
30
82
L04AD01
ATC
ciclosporin; systemic
24.1
8.2
11
5
R60.0
ICD-10 Finland
Localized oedema
5.1
8.0
26
63
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.2
8.0
33
102
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
6.5
7.8
20
36
S76
ICPC
Skin infection other
8.7
7.7
16
21
XF400
NOMESCO Finland
ECG with 12 standard connections
4.1
7.6
32
100
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.7
7.4
26
68
N02AJ06
ATC
codeine and paracetamol; systemic
3.1
7.3
54
260
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
32.3
7.3
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
7.2
44
185
N02AA05
ATC
oxycodone; systemic
4.0
7.0
29
89
A41.9
ICD-10 Finland
Sepsis, unspecified
10.3
7.0
13
14
A28
ICPC
Limited function/disability NOS
3.8
6.9
31
103
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
6.7
35
129
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.3
6.7
20
44
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
12.0
6.4
11
10
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.0
6.4
15
24
J01DA01
ATC
[U] cefalexin; systemic
2.9
6.4
80
521
J01MA12
ATC
levofloxacin; systemic
3.5
6.3
33
120
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.7
6.3
21
52
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
6.3
6
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.6
6.3
29
98
TQW80
NOMESCO Finland
Local dermatologic skincare
10.9
6.2
11
11
S91.3
ICD-10 Finland
Open wound of other parts of foot
16.1
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
11
29.70
36.99
1.2
1.1
—
—
—
0
0
25
17
18.20
28.77
1.4
1.3
—
—
—
0
0
22
18
14.67
22.70
2.5
2.7
3.6
4.6
g/l
0.87
22
18
22
47
5.48
10.23
3.9
3.0
—
—
—
0
0
41
148
3.66
9.70
2.6
1.8
32.0
29.7
s
1.35
41
143
52
219
3.38
9.66
1.8
1.6
1.0
1.4
mg/l
0.87
43
177
53
229
3.31
9.40
3.5
2.4
—
—
—
0
0
97
608
3.82
9.07
16.6
9.3
5.1
4.4
e9/l
0.57
89
534
15
27
6.19
8.24
1.2
1.0
—
—
—
0
0
24
73
3.84
7.13
1.9
1.4
—
—
—
0
0
45
204
2.90
7.02
4.6
3.5
98.6
66.2
ng/l
0.18
39
165
83
517
2.86
6.99
9.7
7.6
1.2
1.2
mmol/l
0.26
74
435
15
32
5.20
6.89
1.9
1.6
—
—
—
0
0
15
32
5.20
6.89
2.4
2.1
—
—
—
0
0
71
411
2.72
6.86
2.3
2.0
86.6
95.2
pmol/l
0.98
43
192
10
14
7.69
6.80
1.1
1.3
—
—
—
0
0
67
382
2.66
6.60
5.1
3.4
—
—
—
0
0
21
62
3.88
6.48
2.9
1.7
—
—
—
0
0
40
180
2.81
6.24
2.8
1.9
—
—
—
0
0
31
123
3.03
6.05
27.6
20.3
1.5
1.2
inr
0.63
13
15
15
36
4.61
6.01
2.5
2.2
—
—
—
0
0
76
476
2.56
5.96
9.1
6.8
1.2
1.2
mmol/l
0.22
68
433
70
437
2.40
5.32
2.9
2.3
75.9
77.0
nmol/l
0.09
63
380
62
367
2.39
5.32
5.6
3.1
2.4
2.4
mmol/l
0.07
55
314
48
258
2.41
5.06
3.8
2.8
352.1
7115.1
umol/l
1.54
41
220
12
29
4.48
4.74
1.1
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
25
4.73
4.66
2.6
2.4
0.3
0.5
u/ml
—
6
12
28
123
2.65
4.45
3.5
2.7
7.1
8.0
umol/l
0.17
23
109
37
193
2.31
4.06
3.2
3.0
0.9
0.9
e6/l
0.03
23
110
35
182
2.29
3.85
3.3
3.4
2.0
2.4
e6/l
0.13
21
100
7
8
9.19
3.82
1.1
1.3
—
—
—
0
0
6
5
12.51
3.80
1.3
1.2
15.2
13.0
umol/l
—
6
5
19
78
2.70
3.41
1.8
2.4
6.3
7.1
ug/l
0.12
14
70
23
105
2.46
3.35
6.6
3.2
—
—
—
0
0
52
331
1.99
3.34
2.8
3.1
77.9
29.7
u/l
0.53
47
313
7
11
6.67
3.23
1.3
1.4
—
—
—
0
0
33
187
2.05
2.87
1.3
1.3
27.6
28.5
iu/ml
—
8
63
25
129
2.18
2.75
2.9
1.8
—
—
—
0
0
65
469
1.82
2.69
5.5
4.2
—
—
—
0
0
41
257
1.89
2.65
1.8
1.6
20.5
21.9
nmol/l
0.18
34
215
68
501
1.80
2.60
3.6
3.8
0.0
0.0
estimate
—
9
101
47
315
1.80
2.43
5.1
3.2
0.4
0.4
e6/l
0.07
37
242
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
24
130
2.05
2.33
3.0
1.8
—
—
—
0
0
107
926
2.20
2.29
5.3
4.7
2.2
2.0
mu/l
0.71
97
833
5
9
5.73
2.23
1.0
1.0
—
—
—
0
0
5
9
5.73
2.23
1.0
1.1
—
—
—
0
0
8
24
3.49
2.22
1.3
1.2
—
—
—
0
0
67
509
1.69
2.16
5.1
5.2
0.0
0.0
estimate
—
9
98
5
10
5.16
2.09
1.0
1.3
—
—
—
0
0
6
15
4.15
2.06
1.2
1.1
—
—
—
0
0
82
665
1.70
2.01
4.4
3.0
73.0
49.5
u/l
0.81
76
621
91
764
1.73
1.91
4.4
3.9
14.8
14.9
pmol/l
0.15
84
683
7
22
3.31
1.91
1.4
1.6
—
—
—
0
0
7
22
3.31
1.91
1.4
1.6
—
—
—
0
0
27
164
1.83
1.88
1.4
1.3
40.4
12.4
u/ml
0.57
13
57
12
53
2.40
1.87
2.7
3.5
0.2
0.1
e6/l
0.31
12
53
66
517
1.60
1.77
3.8
3.8
0.0
0.0
estimate
—
8
95
7
24
3.03
1.75
2.1
1.5
—
—
—
0
0
112
1013
2.18
1.70
36.6
15.0
28.0
22.8
mg/l
1.00
102
795
7
25
2.91
1.67
1.4
1.2
—
—
—
0
0
18
100
1.94
1.63
6.3
6.9
1.3
1.2
mmol/l
0.26
18
92
13
65
2.12
1.55
7.2
6.1
24.1
25.1
mmol/l
0.41
13
65
6
21
2.95
1.52
1.2
1.4
—
—
—
0
0
23
143
1.75
1.49
5.9
6.7
103.4
103.7
mmol/l
0.07
23
138
33
229
1.60
1.42
1.2
1.2
1.1
0.9
u/ml
—
7
66
7
29
2.50
1.41
2.7
2.3
—
—
—
0
0
5
17
3.02
1.37
1.8
1.4
—
—
—
0
0
6
25
2.47
1.26
1.3
2.0
—
—
—
0
0
105
956
1.67
1.19
34.5
14.1
78.3
79.3
ml/min/173m2
0.17
89
773
20
131
1.63
1.08
9.2
11.1
0.3
1.3
mmol/l
0.47
15
108
43
335
1.44
1.06
3.5
3.4
1368.8
1210.1
ng/l
0.19
38
287
0
31
0.00
0.98
0.0
1.6
—
—
—
0
0
8
42
1.97
0.90
1.3
1.4
—
—
—
0
0
107
1003
1.51
0.77
5.9
4.5
6.6
6.0
mmol/l
0.61
98
915
5
23
2.22
0.77
1.4
1.4
—
—
—
0
0
9
55
1.69
0.75
1.9
4.0
24.8
24.7
mmol/l
—
9
49
9
56
1.65
0.74
1.9
2.8
1.5
1.2
%
—
9
56
10
61
1.70
0.71
2.0
3.3
3.8
4.3
pmol/l
—
10
56
100
931
1.40
0.70
7.8
5.8
42.3
40.1
mmol/mol
1.17
94
861
5
29
1.75
0.64
1.6
1.4
—
—
—
0
0
33
267
1.32
0.63
4.4
4.0
0.0
0.0
estimate
—
9
94
10
64
1.61
0.60
1.5
1.4
—
—
—
0
0
108
1029
1.41
0.54
5.1
5.0
2.5
2.7
mmol/l
1.80
100
938
27
220
1.29
0.49
3.2
4.2
20.8
21.6
%
0.09
11
90
5
81
0.60
0.47
3.8
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.49
0.41
1.2
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
14
110
1.31
0.33
6.1
4.9
34.8
31.9
%
—
8
68
11
83
1.36
0.33
2.9
3.3
90.4
59.8
ml/min/173m2
—
5
31
15
121
1.27
0.30
5.1
4.2
2.5
46.7
ug/l
—
9
100
5
74
0.66
0.27
3.8
1.8
—
—
—
0
0
5
37
1.37
0.24
1.2
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
43
402
1.11
0.17
4.9
4.1
31.8
53.3
ng/l
0.75
32
289
7
85
0.81
0.15
9.7
4.0
1.2
1.2
mmol/l
—
7
74
13
112
1.18
0.15
6.2
8.2
—
—
—
0
0
18
161
1.14
0.14
2.2
2.7
0.6
0.7
ug/l
0.50
13
98
6
54
1.12
0.09
1.3
1.0
—
—
—
0
0
40
388
1.05
0.04
3.9
3.8
—
—
—
0
0
97
971
1.00
0.00
4.2
4.0
1.3
1.3
mmol/l
0.01
91
884
62
617
1.01
0.00
2.9
2.9
—
—
—
0
0
15
155
0.96
0.00
1.3
1.4
—
—
—
0
0
17
165
1.04
0.00
2.0
1.4
—
—
—
0
0
101
1006
1.02
0.00
4.8
4.5
4.3
4.6
mmol/l
2.61
95
924
100
999
1.01
0.00
4.7
4.4
1.4
1.5
mmol/l
3.00
94
910
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
7
72
0.97
0.00
11.6
13.1
22.8
24.8
mmol/l
—
7
66
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.9
—
—
—
0
0
5
59
0.84
0.00
1.4
1.3
—
—
—
0
0
7
79
0.88
0.00
1.1
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_LIVEDOIDVASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LIVEDOIDVASC | 2.31 [1.71, 3.12] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 387 females with L12_LIVEDOIDVASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LIVEDOIDVASC | 2.531 [1.81, 3.53] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 258 males with L12_LIVEDOIDVASC died.
Mortality risk
Mortality risk for people of age
years, who have L12_LIVEDOIDVASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.23% | 0.457% |
| 5 | 1.255% | 2.884% |
| 10 | 3.34% | 7.557% |
| 15 | 5.871% | 13.411% |
| 20 | 10.136% | 22.15% |
Relationships between endpoints
↥Index endpoint: L12_LIVEDOIDVASC – Livedoid vasculitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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