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Absence of one kidney

Q17_ABSENCE_OF_ONE_KIDNEY_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 Q60.0
  • Hospital discharge: ICD-10 Q60.0
  • Cause of death: ICD-10 Q60.0

3 out of 7 registries used, show all original rules.

115

4. Check minimum number of events

None

115

5. Include endpoints

None

115

6. Filter based on genotype QC (FinnGen only)

104

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 104 52 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 50.27 40.04 60.50

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
115
Matched controls
1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
166.0
115
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
16.9
36.8
35
29
A11CC03
ATC
alfacalcidol; systemic
40.5
18.8
23
7
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
29.8
18.2
24
10
205
Kela drug reimbursment
Chronic hypertension
4.4
12.8
45
147
KA1AE
NOMESCO Finland
Kidney ultrasound examination
42.6
12.5
15
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
24.6
12.4
17
8
Z94.0
ICD-10 Finland
Kidney transplant status
34.1
12.0
15
5
A12AA04
ATC
calcium carbonate; oral
26.2
11.9
16
7
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.6
11.4
22
25
N19
ICD-10 Finland
Unspecified kidney failure
14.0
11.3
19
16
N18.8
ICD-10 Finland
Other chronic renal failure
15.0
11.1
18
14
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
66.3
10.8
12
*
UKC02
NOMESCO Finland
Cystoscopy
4.8
10.7
29
76
127
Kela drug reimbursment
Transplant complication
19.7
9.7
14
8
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
33.1
9.6
12
*
137
Kela drug reimbursment
Uraemia requiring dialysis
26.5
9.1
12
5
L04AD02
ATC
tacrolimus; systemic
54.2
8.8
10
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.1
8.8
28
83
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
30.1
8.7
11
*
7530A
ICD-9 Finland
Congenital anomalies of urinary system, Renal agenesis and dysgenesis[AGENESIA RENIS]
+∞
8.4
8
*
75301
ICD-8 Finland
Congenital anomalies of urinary system, Agenesis renis unilateralis
+∞
8.4
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.2
8.4
26
75
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
18.9
8.3
12
7
TK800
NOMESCO Finland
Hemodialysis
18.9
8.3
12
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
8.1
32
110
L04AA06
ATC
mycophenolic acid; systemic
16.5
7.9
12
8
N18.0
ICD-10 Finland
End-stage renal disease
85.4
7.5
8
*
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
7.4
7
*
B05DA
ATC
Isotonic solutions
32.2
7.3
9
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
32.2
7.3
9
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
42.6
6.8
8
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
42.6
6.8
8
*
TK820
NOMESCO Finland
Peritoneal dialysis
42.6
6.8
8
*
8312/3-C64.9
ICD-O-3
Renal cell carcinoma, NOS, of kidney, NOS
73.8
6.5
7
*
M04AA01
ATC
allopurinol; systemic
3.6
6.5
24
78
U14
ICPC
Kidney symptom/complaint
12.0
6.4
11
10
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.5
6.4
25
84
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
+∞
6.3
6
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
236
5.03
16.83
7.4
3.8
28.78
12.33
mg/mmol
1.19
48
142
61
220
4.78
15.71
6.8
3.1
175.66
87.34
mg/l
1.02
47
134
66
266
4.48
14.38
6.7
3.7
7.27
7.53
mmol/l
0.17
58
225
58
266
3.38
9.48
16.4
3.7
7.39
7.41
ph
—
10
50
32
100
4.05
9.35
11.8
10.1
—
—
—
0
0
21
47
5.24
9.27
4.4
6.6
0.32
0.49
g/l
0.30
15
24
47
198
3.32
8.69
6.2
2.9
524.50
552.67
mosm/kgh2o
0.37
42
167
32
111
3.61
7.96
10.4
9.0
0.57
1.18
mmol/l
0.46
32
87
32
112
3.57
7.84
10.4
8.9
5.98
5.62
kpa
1.64
32
112
26
79
3.96
7.81
9.1
10.8
22.86
23.39
mmol/l
0.44
26
79
81
490
3.21
7.72
6.2
3.7
0.00
0.00
estimate
-0.00
13
114
30
102
3.63
7.67
7.3
9.5
4.72
4.72
kpa
0.00
30
102
77
458
3.06
7.46
21.0
10.5
1.23
1.22
mmol/l
0.46
70
394
35
135
3.29
7.33
8.4
2.3
26.26
21.37
%
1.05
30
123
73
425
2.96
7.30
21.1
9.9
1.23
1.22
mmol/l
1.15
68
394
96
658
3.78
7.11
9.5
4.3
—
—
—
0
0
69
399
2.82
6.84
5.8
3.5
6.70
5.72
ph
—
5
32
60
323
2.79
6.83
9.7
3.3
84.78
45.40
e6/l
0.22
54
251
79
496
2.89
6.59
6.4
3.7
0.00
0.00
estimate
-0.00
12
105
65
374
2.70
6.36
11.0
4.0
43.37
62.27
e6/l
0.38
55
266
53
276
2.71
6.32
3.5
2.8
—
—
—
0
0
18
50
4.08
6.04
1.6
3.3
—
—
—
0
0
77
490
2.73
6.04
8.2
4.9
0.00
0.00
estimate
-0.00
13
109
67
399
2.63
6.00
10.3
5.9
35.19
35.92
g/l
0.46
62
376
37
165
2.83
5.89
5.5
3.5
3.15
1.94
e6/l
0.34
26
100
52
284
2.52
5.46
8.5
3.1
—
—
—
0
0
7
5
14.77
4.63
2.3
2.2
—
—
—
0
0
51
293
2.33
4.62
8.7
3.2
0.35
0.23
e6/l
0.28
45
223
9
12
8.02
4.44
1.0
1.6
—
—
—
0
0
9
15
6.41
3.90
2.0
3.0
—
—
—
0
0
13
34
4.18
3.84
2.2
1.5
—
—
—
0
0
41
230
2.22
3.81
5.6
3.9
—
—
—
0
0
22
93
2.69
3.77
2.0
4.3
66.88
67.68
e9/l
0.03
14
71
7
9
8.19
3.61
1.6
9.9
—
—
—
0
0
38
211
2.20
3.59
7.0
3.9
1.01
1.02
kg/l
—
6
23
14
48
3.18
3.43
7.6
11.1
0.65
0.69
%
0.17
14
48
24
114
2.40
3.23
8.7
11.5
104.33
104.28
mmol/l
0.03
24
114
50
322
1.98
3.12
4.9
3.5
2.40
2.36
mmol/l
1.56
45
285
8
16
5.29
3.11
1.7
1.3
—
—
—
0
0
11
32
3.69
2.99
2.0
2.7
—
—
—
0
0
9
22
4.34
2.95
4.6
25.3
—
—
—
0
0
51
336
1.93
2.94
2.2
1.8
100.09
96.52
pmol/l
0.23
27
185
43
270
1.95
2.84
5.6
3.2
—
—
—
0
0
5
6
8.64
2.77
2.4
23.3
13.14
175.83
g/mol
—
5
6
14
55
2.76
2.73
7.8
12.5
121.71
125.91
g/l
0.24
14
55
7
15
4.89
2.64
1.9
1.1
—
—
—
0
0
9
25
3.81
2.64
6.0
3.2
—
—
—
0
0
8
20
4.22
2.62
4.3
22.2
78.13
63.36
%
—
8
20
43
277
1.88
2.59
7.5
3.9
0.00
0.00
estimate
—
10
107
14
57
2.66
2.56
1.4
1.5
—
—
—
0
0
17
77
2.42
2.52
7.0
4.1
—
—
—
0
0
7
16
4.58
2.51
11.3
2.9
—
—
—
0
0
19
91
2.30
2.50
8.0
7.8
—
—
—
0
0
68
517
1.77
2.30
6.8
7.7
0.04
0.04
e9/l
0.23
61
452
6
13
4.80
2.30
1.0
1.8
—
—
—
0
0
6
13
4.80
2.30
2.8
33.2
13.25
10.47
%
—
6
13
11
41
2.86
2.28
10.5
3.8
25.51
24.04
mmol/l
0.94
11
41
76
600
1.79
2.23
7.7
11.5
4.24
4.11
e9/l
0.18
66
533
70
540
1.76
2.22
6.8
7.7
1.84
2.02
e9/l
1.01
62
490
65
496
1.71
2.10
7.2
8.6
—
—
—
0
0
67
516
1.72
2.09
6.8
7.7
0.59
0.59
e9/l
0.02
60
453
5
10
5.17
2.09
1.4
1.4
—
—
—
0
0
7
21
3.48
2.00
1.0
1.3
—
—
—
0
0
37
245
1.75
1.97
8.4
4.8
—
—
—
0
0
72
572
1.69
1.95
9.8
7.3
6.63
6.49
mmol/l
0.22
67
532
27
164
1.84
1.90
1.9
1.7
1256.45
1272.95
nmol/l
0.03
22
122
95
821
1.90
1.85
5.3
4.0
1.32
1.26
mmol/l
0.27
88
759
25
151
1.84
1.79
3.4
1.5
—
—
—
0
0
6
18
3.46
1.77
4.5
3.1
—
—
—
0
0
54
406
1.62
1.76
21.5
14.0
1.07
1.24
inr
0.92
13
127
43
307
1.64
1.71
3.2
2.9
—
—
—
0
0
67
535
1.60
1.67
7.0
8.3
0.19
0.19
e9/l
0.00
60
483
46
338
1.60
1.61
3.3
4.1
43.33
37.01
ng/l
0.13
33
235
6
20
3.11
1.60
3.3
3.3
62.00
57.50
%
—
6
20
6
20
3.11
1.60
1.8
2.5
1.43
1.73
mmol/l
—
6
20
6
20
3.11
1.60
3.3
3.1
4.08
4.78
e9/l
—
6
20
106
970
2.18
1.57
27.5
14.9
24.40
21.93
mg/l
0.31
89
766
16
87
1.97
1.55
2.4
1.6
—
—
—
0
0
96
849
1.79
1.51
5.8
4.3
1.48
1.44
mmol/l
0.45
89
781
9
38
2.48
1.49
14.9
4.4
—
—
—
0
0
7
28
2.59
1.47
1.9
1.3
—
—
—
0
0
9
39
2.42
1.47
1.8
1.8
—
—
—
0
0
96
853
1.76
1.43
5.9
4.4
4.42
4.56
mmol/l
0.76
89
793
97
865
1.78
1.42
5.9
4.8
2.51
2.71
mmol/l
1.49
89
792
16
90
1.90
1.41
7.8
15.3
1.40
1.11
mmol/l
0.06
11
72
7
29
2.50
1.41
7.0
5.6
22.70
24.38
mmol/l
—
7
29
14
75
1.99
1.41
10.9
5.4
—
—
—
0
0
34
239
1.60
1.41
3.1
2.0
—
—
—
0
0
0
37
0.00
1.37
0.0
1.5
—
—
—
0
0
15
86
1.86
1.26
1.9
1.3
—
—
—
0
0
57
465
1.45
1.14
15.2
12.1
0.01
0.03
e9/l
0.32
42
378
7
31
2.34
1.12
1.1
1.3
—
—
—
0
0
8
41
2.02
1.11
8.1
23.0
—
—
—
0
0
106
991
1.89
1.08
29.1
13.5
—
—
—
0
0
28
200
1.53
1.07
3.2
1.7
—
—
—
0
0
21
140
1.61
1.07
3.0
2.3
—
—
—
0
0
14
84
1.76
1.03
2.5
4.1
9.11
9.03
g/l
0.03
14
78
10
55
1.90
0.95
9.4
13.0
—
—
—
0
0
32
241
1.45
0.95
2.8
2.3
2.82
2.85
mg/l
0.04
25
202
12
71
1.77
0.93
2.1
2.1
1.10
1.14
g/l
0.06
12
66
31
239
1.41
0.81
4.0
4.5
—
—
—
0
0
9
53
1.76
0.77
1.3
2.4
296.56
212.26
ng/l
—
9
47
5
24
2.13
0.75
20.0
16.5
—
—
—
0
0
5
94
0.51
0.70
1.2
1.5
—
—
—
0
0
14
95
1.54
0.68
1.7
1.7
—
—
—
0
0
16
113
1.48
0.65
2.9
1.6
—
—
—
0
0
88
814
1.35
0.63
8.0
5.3
39.01
39.21
mmol/mol
0.08
83
758
8
50
1.64
0.63
2.5
3.5
—
—
—
0
0
17
123
1.45
0.62
1.5
1.2
—
—
—
0
0
0
20
0.00
0.61
0.0
4.0
—
—
—
0
0
22
168
1.38
0.61
2.5
2.8
2.52
2.44
mmol/l
1.87
17
147
6
38
1.61
0.55
5.0
14.8
25.92
23.89
mmol/l
—
6
38
11
75
1.52
0.53
2.9
6.7
0.00
0.09
%
—
5
23
67
607
1.25
0.51
4.0
3.7
—
—
—
0
0
11
77
1.47
0.47
2.9
6.6
0.00
0.16
%
—
5
25
13
172
0.72
0.45
2.2
2.8
0.69
0.80
ug/l
—
8
115
5
31
1.64
0.43
7.0
3.0
—
—
—
0
0
5
33
1.54
0.42
1.2
1.2
—
—
—
0
0
8
60
1.36
0.41
1.5
1.2
—
—
—
0
0
31
265
1.23
0.39
5.9
7.9
—
—
—
0
0
6
43
1.42
0.35
2.7
1.8
—
—
—
0
0
11
82
1.38
0.35
2.9
6.4
0.60
0.74
%
—
5
31
22
261
0.81
0.35
1.3
1.5
0.58
1.24
u/ml
—
6
59
7
52
1.37
0.32
1.6
1.2
—
—
—
0
0
12
93
1.32
0.31
8.3
3.4
—
—
—
0
0
20
167
1.24
0.31
2.4
3.0
97.23
252.36
ng/l
0.64
13
120
34
304
1.17
0.27
3.9
2.9
—
—
—
0
0
26
227
1.19
0.27
1.8
2.8
0.97
1.30
mg/l
0.42
20
187
9
72
1.27
0.26
1.7
1.3
229.00
542.26
u/ml
—
9
65
109
1069
1.38
0.25
39.8
22.4
39.52
40.37
%
0.88
101
1026
109
1069
1.38
0.25
39.8
22.0
4.43
4.53
e12/l
0.87
104
1039
109
1070
1.36
0.25
39.9
22.1
6.99
6.76
e9/l
0.53
104
1041
5
39
1.29
0.23
1.0
1.7
31.26
19.66
iu/l
—
5
30
33
298
1.15
0.23
1.5
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
25.67
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
12
142
0.83
0.18
1.5
1.6
—
—
—
0
0
22
246
0.87
0.18
1.5
1.6
1.96
2.14
g/l
0.21
14
145
90
874
1.14
0.17
4.4
4.4
2.25
1.92
mu/l
0.48
83
790
5
70
0.70
0.17
1.2
1.1
—
—
—
0
0
12
102
1.20
0.16
1.2
1.7
—
—
—
0
0
13
114
1.16
0.12
1.2
1.2
—
—
—
0
0
6
72
0.82
0.08
1.0
1.4
—
—
—
0
0
8
90
0.88
0.07
2.8
2.3
15.56
12.41
nmol/l
—
8
84
36
346
1.06
0.06
2.2
2.1
—
—
—
0
0
10
90
1.12
0.05
1.2
1.2
—
—
—
0
0
10
93
1.08
0.02
1.5
1.4
—
—
—
0
0
85
845
1.02
0.00
6.8
4.4
5.86
5.83
mmol/l
0.10
79
761
14
141
0.99
0.00
1.9
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
246.33
—
0
9
0
5
0.00
0.00
0.0
21.8
—
—
—
0
0
0
9
0.00
0.00
0.0
17.0
—
889.33
—
0
9
0
8
0.00
0.00
0.0
1.3
—
7.69
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
9.2
—
459.89
—
0
9
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
4.28
—
0
5
0
8
0.00
0.00
0.0
1.6
—
0.99
—
0
8
0
8
0.00
0.00
0.0
1.1
—
160.63
—
0
8
0
5
0.00
0.00
0.0
2.8
—
3.95
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
76.00
—
0
5
6
65
0.92
-0.00
1.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
66
0.90
-0.00
2.8
3.5
3.11
8.23
e9/l
—
6
58
6
59
1.02
-0.00
3.7
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
31.0
—
0.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
2.03
—
0
7
0
6
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_ABSENCE_OF_ONE_KIDNEY_WIDE – Absence of one kidney

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).