Congenital stenosis of pulmonary valve

Q17_CONGENITAL_STENOSIS_OF_PULMONARY_VALVE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q22.1
  • Hospital discharge: ICD-9 7460C
  • Hospital discharge: ICD-8 74663
  • Cause of death: ICD-10 Q22.1
  • Cause of death: ICD-9 7460C
  • Cause of death: ICD-8 74663

2 out of 7 registries used, show all original rules.

266

4. Check minimum number of events

None

266

5. Include endpoints

None

266

6. Filter based on genotype QC (FinnGen only)

245

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 245 138 107
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 7.06 6.19 8.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
266
Matched controls
2660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
207.4
171
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
+∞
114.0
101
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
12.3
90.0
120
167
201
Kela drug reimbursment
Chronic cardiac insufficiency
29.6
88.3
62
27
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
9.8
79.7
147
298
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
14.1
71.7
75
72
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
15.2
61.2
59
49
Q21.10
ICD-10 Finland
Persistent ostium secundum
22.2
52.0
40
21
I37.0
ICD-10 Finland
Pulmonary valve stenosis
593.5
51.2
49
*
XF404
NOMESCO Finland
Ambulatory ECG
10.4
50.5
64
79
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
23.2
50.4
38
19
XF400
NOMESCO Finland
ECG with 12 standard connections
6.4
44.9
101
233
C01AA05
ATC
digoxin; systemic
17.7
43.4
37
24
XF402
NOMESCO Finland
ECG with work load test
9.2
40.7
55
73
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
14.2
37.4
36
29
B01AA03
ATC
warfarin; systemic
7.3
36.1
61
104
C03DA01
ATC
spironolactone; oral
7.6
34.5
55
88
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
34.1
32
*
WX872
NOMESCO Finland
Intensive care
14.5
32.8
31
24
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
31.9
30
*
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
31.9
30
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
97.1
31.6
34
*
C03CA01
ATC
furosemide; systemic
5.2
30.4
78
196
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
27.8
145
614
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.7
27.6
49
87
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.8
25.8
72
192
FM2CE, ,
NOMESCO Finland
8.6
25.7
35
46
TFP20
NOMESCO Finland
Cardiodefibrillation
9.2
24.9
32
39
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
54.0
24.8
29
6
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
262.7
24.1
24
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
49.8
22.8
27
6
TPH07
NOMESCO Finland
Cathetrisation of artery
5.1
22.3
53
123
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.3
21.8
49
108
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
65.6
21.3
24
*
Q87.14
ICD-10 Finland
Noonan's syndrome
119.4
20.9
22
*
207
Kela drug reimbursment
Chronic arrhythmias
6.1
20.6
39
73
31
HP
Congenital heart failure surgery
52.5
20.5
24
5
61
HP
Catheterization and pressure measurement of the left side of the heart
62.6
20.2
23
*
62
HP
Catheterization and pressure measurement of the right side of the heart
102.0
17.8
19
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
13.9
17.6
30
24
Z2221
NOMESCO Finland
Medical doctor
3.1
17.6
109
484
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.8
17.2
34
66
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
15.7
16.7
27
19
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
16.8
16.6
26
17
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.6
16.4
43
107
ZXE20
NOMESCO Finland
More than three and less than five hours
3.8
16.2
57
177
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.0
15.7
51
149
C01BD01
ATC
amiodarone; systemic
19.2
15.4
23
13
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
15.0
124
633
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
19.8
15.0
22
12
Q21.30
ICD-10 Finland
Tetralogy of Fallot
84.9
14.7
16
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
14.7
14
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
158.3
14.6
15
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.2
14.4
42
113
I50.9
ICD-10 Finland
Heart failure, unspecified
5.4
14.4
30
61
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
14.3
98
451
XF600
NOMESCO Finland
Bloodpressure measurement
4.2
14.1
41
110
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
36.1
13.7
17
5
C07AA07
ATC
sotalol; systemic
19.5
13.6
20
11
WX892
NOMESCO Finland
Monitored bed care
4.2
13.1
38
102
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
73.5
12.7
14
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
12.6
12
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
12.6
12
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
136.2
12.5
13
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
39.6
12.3
15
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
16.9
12.3
19
12
WX882
NOMESCO Finland
High dependency care
4.4
12.3
33
83
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
31.6
11.8
15
5
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
68.0
11.7
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
11.6
66
272
74734
ICD-8 Finland
Other congenital anomalies of circulatory system, Stenosis, hypoplasia sive aplasia arteriae pulmonalis
+∞
11.5
11
*
Q20.48
ICD-10 Finland
Single ventricle
125.2
11.5
12
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
16.4
11.0
17
11
R4110
NOMESCO Finland
Physiotherapy
2.5
10.8
89
440
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
10.6
71
317
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
10.2
105
572
Q21.0
ICD-10 Finland
Ventricular septal defect
41.8
10.0
12
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
5.2
10.0
21
43
Q22.0
ICD-10 Finland
Pulmonary valve atresia
57.1
9.7
11
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
57.1
9.7
11
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
18.4
9.5
14
8
ZX120
NOMESCO Finland
Intravenous
3.4
9.5
36
116
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
103.6
9.5
10
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
11.3
9.4
17
16
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
9.4
9
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.1
9.3
27
72
Z3226
NOMESCO Finland
Physiotherapist
2.5
9.0
68
320
Q25.0
ICD-10 Finland
Patent ductus arteriosus
14.7
8.8
14
10
Q21.21
ICD-10 Finland
Atrioventricular duct
51.7
8.7
10
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.7
8.7
18
22
Z3231
NOMESCO Finland
Registered nurse
2.2
8.6
97
543
K80
ICPC
Cardiac arrhythmia NOS
4.2
8.5
23
58
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
8.4
8
*
AEX
HP
Other pulmonary or pulmonary artery valve procedure
+∞
8.4
8
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
22.8
8.1
11
5
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.9
7.9
24
66
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
11.3
7.9
14
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
7.8
71
362
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
46.4
7.8
9
*
5253
FHL
Cardiac lung machine
46.4
7.8
9
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
10.5
7.6
14
14
ZXE00
NOMESCO Finland
One hour or less
2.1
7.6
116
723
I50.0
ICD-10 Finland
Congestive heart failure
6.8
7.6
18
28
ZXD05
NOMESCO Finland
Urgent procedure
2.1
7.5
91
520
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
82.3
7.5
8
*
XF620
NOMESCO Finland
Examination of circulation with color method
82.3
7.5
8
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
82.3
7.5
8
*
C07AB07
ATC
bisoprolol; oral
2.1
7.4
88
499
Q21.3
ICD-10 Finland
Tetralogy of Fallot
+∞
7.3
7
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
+∞
7.3
7
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
7.3
7
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
6.4
7.2
18
30
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
30.9
7.2
9
*
7505
FHL
Funicular lysis and orchidopexy
20.7
7.2
10
5
RD210, ,
NOMESCO Finland
4.0
6.9
20
53
I50.1
ICD-10 Finland
Left ventricular failure
8.6
6.9
14
17
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
41.1
6.8
8
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
12.7
6.6
11
9
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
12.7
6.6
11
9
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
71.5
6.5
7
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
71.5
6.5
7
*
Q24.0
ICD-10 Finland
Dextrocardia
71.5
6.5
7
*
7525A
ICD-9 Finland
Congenital anomalies of genital organs, Undescended testicle[RETENTIO TESTIS (CRYPTORCHISMUS)]
18.6
6.3
9
5
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
6.3
6
*
74669
ICD-8 Finland
Congenital anomalies of heart, Aliae maleformationes valvulae pulmonaris sive ventriculi dextri
+∞
6.3
6
*
5504
FHL
Subclavian pulmonary anastomosis (Blalock)
+∞
6.3
6
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
6.3
6
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
6.3
6
*
74646
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium primum
+∞
6.3
6
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.3
6
*
AP3
HP
Catheterization of the right and left side of the heart
+∞
6.3
6
*
Q22.41
ICD-10 Finland
Tricuspid atresia
+∞
6.3
6
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.4
6.2
49
233
XF640, ,
NOMESCO Finland
8.0
6.2
13
17
R62.0
ICD-10 Finland
Delayed milestone
3.8
6.2
19
53
B01AF02
ATC
apixaban; oral
3.8
6.2
19
53
I47.2
ICD-10 Finland
Ventricular tachycardia
8.9
6.1
12
14
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.4
6.0
22
69
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
6.0
36
150

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
146
334
8.47
69.29
6.9
4.3
676.59
683.39
ng/l
0.02
138
282
134
656
3.10
18.39
16.3
8.3
1.40
1.16
inr
1.33
31
193
112
561
2.72
13.83
3.2
2.5
—
—
—
0
0
73
312
2.85
12.01
5.2
3.2
1553.19
523.89
ng/l
1.54
58
191
142
869
2.36
10.70
3.2
2.7
—
—
—
0
0
56
251
2.56
8.15
13.2
12.0
—
—
—
0
0
166
1189
2.05
7.32
5.1
2.9
—
—
—
0
0
73
388
2.21
7.18
5.2
3.1
—
—
—
0
0
72
381
2.22
7.15
5.3
3.9
—
—
—
0
0
82
466
2.10
6.75
3.5
2.7
3.37
2.77
mg/l
0.63
74
407
154
1100
1.95
6.54
8.3
6.3
5.94
6.37
mmol/l
3.11
147
1016
72
395
2.13
6.47
2.8
3.4
1.13
1.07
mg/l
0.07
49
304
44
198
2.46
6.29
11.3
10.4
104.45
104.65
mmol/l
0.09
44
198
155
1149
1.84
5.48
8.6
7.1
28.13
31.89
%
4.64
148
1100
238
2048
2.54
5.41
23.5
12.2
139.10
139.60
mmol/l
2.35
238
1992
148
1091
1.80
5.24
8.9
7.2
3.01
3.02
%
0.01
140
1034
84
521
1.89
5.22
4.0
2.9
19.35
23.66
ng/l
0.27
56
285
149
1102
1.80
5.21
8.9
7.5
8.98
8.29
%
2.05
142
1052
144
1058
1.79
5.11
9.0
7.3
0.54
0.68
%
2.79
136
1000
151
1126
1.79
5.09
8.7
7.0
57.27
53.53
%
4.16
144
1076
50
261
2.13
5.02
18.5
14.4
25.07
24.83
mmol/l
0.21
50
261
93
603
1.83
4.99
8.1
7.8
—
—
—
0
0
119
836
1.77
4.86
15.9
10.2
1.22
1.22
mmol/l
0.64
114
790
50
265
2.09
4.82
8.8
9.7
1.54
1.19
mmol/l
0.42
44
204
47
246
2.11
4.68
2.4
1.9
—
—
—
0
0
126
908
1.74
4.65
15.4
9.9
1.22
1.22
mmol/l
0.30
119
802
22
81
2.87
4.64
17.8
18.4
—
—
—
0
0
15
37
4.23
4.48
5.8
16.3
—
—
—
0
0
154
1185
1.71
4.39
9.2
7.9
0.19
0.20
e9/l
0.19
141
1041
41
210
2.13
4.31
15.5
9.4
—
—
—
0
0
7
6
11.93
4.30
1.1
1.5
—
—
—
0
0
149
1148
1.68
4.13
9.1
7.3
0.04
0.04
e9/l
0.75
138
994
8
10
8.20
4.09
2.1
1.1
—
—
—
0
0
149
1150
1.67
4.08
9.2
7.3
0.62
0.56
e9/l
1.58
138
996
7
7
10.23
4.03
1.0
1.3
14.86
10.29
umol/l
—
7
7
7
7
10.23
4.03
1.1
1.6
—
—
—
0
0
153
1193
1.66
4.00
9.0
7.2
1.77
2.07
e9/l
6.08
143
1056
13
33
4.09
3.85
5.8
16.3
73.85
69.96
%
0.31
13
33
17
61
2.91
3.76
3.1
2.5
—
—
—
0
0
20
80
2.62
3.64
6.2
10.8
0.70
0.68
%
0.11
20
80
22
98
2.36
3.23
16.0
13.0
0.62
0.68
%
0.38
22
98
92
659
1.61
3.20
1.5
1.6
—
—
—
0
0
37
204
1.95
3.19
1.4
1.5
—
—
—
0
0
22
99
2.33
3.16
16.3
12.9
1.69
1.58
%
0.08
22
99
137
1092
1.52
2.90
9.4
8.0
—
—
—
0
0
159
1310
1.53
2.88
11.2
10.1
3.95
3.86
e9/l
0.21
146
1133
58
379
1.68
2.87
3.7
2.7
582.78
582.79
mosm/kgh2o
0.00
50
318
5
6
8.46
2.76
2.8
1.7
27.18
45.50
%
—
5
6
18
79
2.37
2.74
3.4
6.9
0.24
0.38
g/l
0.37
13
55
59
392
1.65
2.74
3.8
2.8
4.77
7.18
e6/l
0.55
51
344
10
30
3.42
2.63
2.4
2.2
—
—
—
0
0
94
704
1.52
2.61
4.6
4.2
8.70
81.83
e6/l
1.18
68
492
28
153
1.93
2.50
2.9
3.4
75.65
67.95
e9/l
0.43
21
109
244
2267
1.92
2.30
17.2
9.3
—
—
—
0
0
6
13
4.69
2.28
1.5
1.9
76.33
72.31
umol/l
—
6
13
11
42
2.69
2.17
1.2
1.2
4.67
3.27
u/ml
—
6
22
17
82
2.15
2.12
2.3
2.4
—
—
—
0
0
8
25
3.27
2.11
2.5
20.9
14.15
11.21
%
—
8
25
66
478
1.51
2.10
2.9
2.5
—
—
—
0
0
5
10
5.07
2.08
3.8
1.2
—
—
—
0
0
33
202
1.72
2.08
1.5
1.5
926.46
1175.70
nmol/l
1.20
27
150
6
15
4.07
2.05
4.3
2.6
—
—
—
0
0
183
1609
1.44
2.01
5.0
3.8
15.35
14.51
pmol/l
3.90
164
1489
36
229
1.66
1.98
2.1
1.7
—
—
—
0
0
9
33
2.79
1.95
2.2
3.4
15.67
8.67
%
—
9
33
9
33
2.79
1.95
2.2
3.5
46.56
62.97
%
—
9
33
5
11
4.61
1.95
2.0
6.9
—
—
—
0
0
78
596
1.44
1.88
4.5
3.6
23.73
46.96
e6/l
0.84
65
460
7
23
3.10
1.81
2.3
2.2
—
—
—
0
0
8
29
2.81
1.80
2.3
3.6
15.13
24.52
%
—
8
29
127
1067
1.36
1.73
11.0
9.2
0.00
0.00
e9/l
0.50
115
842
5
13
3.90
1.72
4.8
2.2
—
—
—
0
0
5
13
3.90
1.72
1.0
1.7
1.02
1.14
g/l
—
5
13
72
551
1.42
1.71
4.5
3.4
0.20
0.26
e6/l
0.16
61
415
72
555
1.41
1.64
4.3
3.3
—
—
—
0
0
180
1605
1.38
1.64
5.1
4.2
37.57
37.97
mmol/mol
0.23
170
1520
12
57
2.16
1.57
1.0
2.4
—
—
—
0
0
8
33
2.47
1.55
2.5
4.1
34.25
16.94
%
—
8
33
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
7
27
2.63
1.52
3.6
3.9
—
—
—
0
0
219
2030
1.45
1.49
26.0
14.1
14.36
14.01
%
0.48
219
2003
87
704
1.35
1.46
2.0
1.9
—
—
—
0
0
7
28
2.54
1.46
5.6
2.1
2.19
1.25
mmol/l
—
7
28
9
39
2.35
1.44
2.2
3.1
1.12
1.30
e9/l
—
9
29
6
22
2.77
1.44
1.2
2.5
—
—
—
0
0
28
184
1.58
1.38
5.6
3.0
10.07
9.40
g/l
0.26
28
176
17
281
0.58
1.38
1.4
1.3
—
—
—
0
0
15
83
1.86
1.34
2.1
1.9
—
—
—
0
0
6
24
2.53
1.31
6.3
2.3
9.62
6.99
mmol/l
—
6
24
153
1357
1.30
1.30
5.0
3.9
—
—
—
0
0
61
475
1.37
1.30
6.0
3.6
7.40
7.40
ph
0.19
12
85
42
308
1.43
1.26
1.7
1.4
20.16
21.00
nmol/l
0.15
37
268
8
36
2.26
1.25
6.2
3.6
52.13
53.14
%
—
8
36
8
36
2.26
1.25
6.3
3.6
2.92
3.60
e9/l
—
8
36
8
36
2.26
1.25
2.3
3.1
0.36
0.17
e9/l
—
8
26
56
709
0.73
1.25
1.5
1.5
0.89
2.28
u/ml
1.23
16
149
257
2493
1.91
1.23
28.5
16.1
29.79
29.77
pg
0.06
257
2468
257
2493
1.91
1.23
28.5
16.1
89.06
88.87
fl
0.24
257
2468
8
37
2.20
1.22
2.3
3.1
349.75
529.46
e6/l
—
8
26
45
338
1.40
1.19
3.3
3.3
3.69
2.47
e6/l
0.27
31
196
0
33
0.00
1.17
0.0
1.7
—
3.11
—
0
33
5
20
2.53
1.15
1.2
1.3
—
—
—
0
0
15
88
1.75
1.14
2.9
2.0
215.90
156.45
u/ml
—
10
42
257
2496
1.88
1.12
29.2
16.4
136.31
136.78
g/l
0.19
257
2468
204
1900
1.32
1.10
5.6
4.3
2.00
1.87
mu/l
0.78
192
1779
50
388
1.36
1.09
4.2
3.7
20.38
11.54
mg/mmol
0.45
32
263
7
33
2.15
1.06
2.0
2.3
638.43
640.09
e6/l
—
7
33
20
130
1.58
1.06
5.2
4.2
—
—
—
0
0
28
197
1.47
1.05
1.5
1.2
—
—
—
0
0
25
173
1.49
1.02
1.5
1.3
264.71
295.16
u/ml
0.07
25
160
228
2165
1.37
1.01
20.5
10.8
22.95
21.01
mg/l
0.39
184
1586
48
375
1.34
1.01
3.6
3.2
110.65
262.99
mg/l
0.41
31
264
233
2221
1.40
1.00
12.2
8.8
24.99
27.59
u/l
1.49
228
2149
18
117
1.58
0.96
4.4
3.6
1.24
1.23
mmol/l
0.21
18
104
59
480
1.29
0.94
1.6
1.8
1.31
1.44
mmol/l
0.56
54
419
67
557
1.27
0.90
1.8
1.7
87.94
99.98
pmol/l
1.80
42
297
11
64
1.75
0.87
1.5
1.9
—
—
—
0
0
8
140
0.56
0.85
3.0
2.3
—
—
—
0
0
6
31
1.96
0.85
2.8
3.6
436.67
374.71
e6/l
—
6
17
10
57
1.78
0.85
1.3
1.5
240.00
273.30
ug/g
—
5
34
65
544
1.26
0.83
3.9
3.4
6.86
8.40
mmol/l
2.29
60
496
13
199
0.64
0.82
1.9
1.9
—
—
—
0
0
17
114
1.52
0.81
1.1
1.1
—
—
—
0
0
6
33
1.84
0.79
11.0
8.3
—
—
—
0
0
159
1466
1.21
0.79
6.0
3.9
8.49
8.66
mm/h
0.07
148
1362
5
25
2.02
0.73
2.0
2.3
—
—
—
0
0
30
380
0.76
0.68
1.7
1.7
—
—
—
0
0
187
1764
1.20
0.67
3.9
3.4
5.68
5.71
mmol/l
0.07
179
1641
14
201
0.68
0.67
2.1
1.9
—
—
—
0
0
14
200
0.68
0.66
2.0
1.9
—
—
—
0
0
37
452
0.79
0.64
4.1
3.1
1.02
1.02
kg/l
—
6
63
28
218
1.32
0.63
1.6
1.9
—
—
—
0
0
14
198
0.69
0.63
2.0
1.9
—
—
—
0
0
5
30
1.68
0.61
1.2
1.1
—
—
—
0
0
33
265
1.28
0.60
1.2
1.4
497.78
528.33
titre
—
9
48
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
9.2
—
0.56
—
0
21
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
8
54
1.50
0.58
1.4
1.2
—
—
—
0
0
10
65
1.56
0.56
5.4
8.2
—
—
—
0
0
17
125
1.38
0.55
1.0
1.2
—
—
—
0
0
6
38
1.59
0.54
3.0
3.2
21.40
34.95
%
—
6
38
14
191
0.72
0.53
1.9
1.9
—
—
—
0
0
6
40
1.51
0.52
2.2
2.6
—
—
—
0
0
10
67
1.51
0.50
6.0
11.3
—
—
—
0
0
18
137
1.34
0.48
3.2
5.8
0.00
0.20
%
—
7
44
16
120
1.35
0.47
4.9
3.5
—
—
—
0
0
184
1762
1.14
0.43
4.0
3.3
1.25
1.27
mmol/l
0.17
176
1654
5
33
1.52
0.41
6.8
2.6
7.84
9.35
kpa
—
5
33
11
79
1.41
0.41
1.9
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
5
34
1.48
0.40
1.0
2.1
6.13
5.35
mmol/24h
—
5
28
55
616
0.86
0.40
1.9
2.1
—
—
—
0
0
12
89
1.36
0.38
1.0
1.1
—
—
—
0
0
9
67
1.36
0.38
1.3
1.1
—
—
—
0
0
9
67
1.36
0.38
1.3
1.1
—
—
—
0
0
12
158
0.75
0.38
2.1
2.0
—
—
—
0
0
14
180
0.77
0.38
1.1
1.3
—
15.00
—
0
6
5
37
1.36
0.37
2.0
1.9
—
—
—
0
0
5
37
1.36
0.37
1.2
1.3
—
—
—
0
0
6
41
1.47
0.36
5.8
2.4
—
—
—
0
0
16
199
0.79
0.34
2.3
2.2
0.54
0.63
ug/l
—
7
100
6
45
1.34
0.34
1.2
1.0
—
—
—
0
0
191
1847
1.12
0.33
4.5
3.8
2.65
2.83
mmol/l
2.11
182
1739
64
583
1.13
0.33
2.3
3.3
2.36
2.37
mmol/l
0.36
58
524
25
213
1.19
0.30
1.6
1.4
—
—
—
0
0
18
148
1.23
0.30
3.2
5.5
0.79
0.83
%
—
7
56
10
76
1.33
0.28
5.1
2.3
—
—
—
0
0
9
119
0.75
0.28
1.1
1.1
—
—
—
0
0
16
132
1.23
0.26
2.4
5.2
0.40
0.61
%
—
5
46
35
313
1.14
0.24
1.3
1.3
17.34
31.49
iu/ml
1.07
11
96
189
1843
1.09
0.22
4.3
3.6
4.36
4.68
mmol/l
4.10
182
1746
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
5.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
25.80
—
0
10
0
10
0.00
0.21
0.0
2.4
—
36.80
—
0
10
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
187
1825
1.08
0.21
4.3
3.6
1.33
1.44
mmol/l
3.26
178
1718
5
43
1.17
0.21
3.6
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
2.9
—
—
—
0
0
0
13
0.00
0.21
0.0
5.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
16
137
1.18
0.19
2.1
1.6
—
—
—
0
0
6
53
1.14
0.19
1.3
1.3
—
—
—
0
0
6
53
1.14
0.19
1.0
1.2
—
—
—
0
0
7
58
1.21
0.18
1.0
1.2
—
—
—
0
0
7
60
1.17
0.18
1.1
1.1
—
—
—
0
0
16
184
0.86
0.18
1.3
1.4
—
—
—
0
0
7
62
1.13
0.17
1.0
1.4
—
—
—
0
0
10
82
1.23
0.17
1.4
1.6
—
—
—
0
0
9
79
1.14
0.15
2.4
1.5
—
—
—
0
0
9
79
1.14
0.15
1.4
1.5
—
—
—
0
0
9
79
1.14
0.15
1.4
1.5
—
—
—
0
0
47
499
0.93
0.14
4.6
3.3
0.00
0.01
estimate
0.50
17
169
22
199
1.12
0.14
1.4
1.6
—
—
—
0
0
46
488
0.93
0.13
1.6
1.7
—
—
—
0
0
21
190
1.11
0.13
1.3
1.2
184.86
147.25
iu/ml
—
7
62
14
123
1.15
0.12
1.4
1.4
—
—
—
0
0
43
455
0.93
0.12
3.8
3.3
—
—
—
0
0
94
969
0.95
0.11
4.0
3.2
0.00
0.00
estimate
-0.00
17
165
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
26
244
1.07
0.08
1.2
1.2
—
—
—
0
0
56
540
1.05
0.08
3.6
2.6
—
—
—
0
0
71
730
0.96
0.07
2.5
2.3
—
—
—
0
0
10
112
0.89
0.07
2.3
1.6
—
—
—
0
0
10
89
1.13
0.07
2.2
2.3
—
—
—
0
0
28
295
0.94
0.07
1.3
1.2
—
—
—
0
0
94
959
0.97
0.06
5.4
4.5
0.00
0.00
estimate
-0.00
17
174
16
171
0.93
0.05
1.2
1.3
—
—
—
0
0
79
804
0.98
0.04
3.6
3.0
5.57
5.91
ph
—
7
81
95
962
0.98
0.03
3.9
3.1
0.00
0.00
estimate
-0.00
18
173
64
651
0.98
0.03
1.8
1.5
1.92
1.99
g/l
0.18
43
363
10
93
1.08
0.02
1.3
1.1
—
—
—
0
0
14
142
0.99
0.00
1.4
1.2
—
30.58
—
0
6
17
172
0.99
0.00
2.9
1.7
—
—
—
0
0
17
169
1.01
0.00
4.6
2.7
—
—
—
0
0
34
341
1.00
0.00
1.4
1.6
—
—
—
0
0
46
461
1.00
0.00
1.7
1.7
—
—
—
0
0
31
306
1.01
0.00
1.3
1.3
21.23
7.21
u/ml
0.30
13
122
37
374
0.99
0.00
2.8
2.9
258.11
90.58
ug/g
0.50
28
293
15
155
0.97
0.00
1.7
2.5
20621.74
3675.17
u/l
—
5
55
10
105
0.95
0.00
2.7
1.8
—
—
—
0
0
6
61
0.98
0.00
12.3
6.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
9
97
0.93
0.00
1.8
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
79
0.88
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
17.5
—
0.72
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
81.40
—
0
5
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
3.88
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
17.32
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
—
4.81
—
0
10
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.8
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
149.29
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
1.19
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.86
—
0
5

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_CONGENITAL_STENOSIS_OF_PULMONARY_VALVE – Congenital stenosis of pulmonary valve

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).