≡ Risteys
FG R12 + FR

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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Findings of drugs and other substances, not normally found in blood

Endpoint Browser

R18_FINDI_DRUGS_OTHER_SUBST_NOT_NORMALLY_FOUND_BLOOD

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — R78
  • Cause of death: ICD-10 — R78

2 out of 7 registries used, show all original rules.

155

4. Check minimum number of events

None

155

5. Include endpoints

None

155

6. Filter based on genotype QC (FinnGen only)

155

Control definitions (FinnGen only)

Control exclude
R18_ABNORMAL_FINDI_EXAMI_BLOOD_WO_DIAGNOSIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R7
Name in latin
Reperta medicamentorum et aliarum substantiarum non usitate in sanguine praesentium

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 155 70 85
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 56.27 51.76 59.98

-FinnGen-

Age distribution of first events

01020304050607080051015202530AgeIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023051015202530YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
136
Matched controls
1357
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R78.8
ICD-10 Finland
Finding of other specified substances, not normally found in blood
+∞
40.7
37
*
R78.0
ICD-10 Finland
Finding of alcohol in blood
+∞
38.4
35
*
N05AN01
ATC
lithium; oral
39.8
32.1
40
14
R78.5
ICD-10 Finland
Finding of psychotropic drug in blood
+∞
24.7
23
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
10.2
20.8
44
61
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
30.2
20.5
27
11
R78.4
ICD-10 Finland
Finding of other drugs of addictive potential in blood
+∞
20.3
19
*
N03AG01
ATC
valproic acid; systemic, rectal
13.4
19.1
34
33
N05AH04
ATC
quetiapine; oral
6.6
18.4
55
127
T36
ICD-10 Finland
Poisoning by systemic antibiotics
14.5
18.2
31
27
N05AH03
ATC
olanzapine; systemic
10.8
17.6
35
42
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
30.4
17.6
23
9
R78.9
ICD-10 Finland
Finding of unspecified substance, not normally found in blood
+∞
14.9
14
*
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
55.7
13.1
15
*
F31
ICD-10 Finland
Bipolar affective disorder
35.9
12.9
16
5
N07BB01
ATC
disulfiram; oral
12.3
12.9
23
22
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
33.4
11.9
15
5
F31.8
ICD-10 Finland
Other bipolar affective disorders
38.7
11.5
14
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.1
10.8
27
46
N05AF03
ATC
chlorprothixene; systemic
11.4
10.4
19
19
N05AA02
ATC
levomepromazine; systemic
8.2
10.0
22
31
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
59.3
9.8
11
*
N05BA01
ATC
diazepam; systemic, rectal
4.5
9.6
36
100
AA1AD
NOMESCO Finland
CT of head and brain
3.5
9.2
51
197
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
17.8
8.7
13
8
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
14.0
8.6
14
11
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
14.0
8.6
14
11
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.1
8.4
17
21
N05AX08
ATC
risperidone; systemic
4.9
8.2
27
65
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
35.7
8.2
10
*
E86
ICD-10 Finland
Volume depletion
12.9
7.8
13
11
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
26.7
7.7
10
*
R53
ICD-10 Finland
Malaise and fatigue
3.4
7.5
40
149
SPAT1243
SPAT
Psychiatric/psychological examination
13.0
7.2
12
10
N05BA06
ATC
lorazepam; systemic, sublingual
6.1
6.9
18
33
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.0
6.9
44
185
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
17.8
6.9
10
6
N05AB03
ATC
perphenazine; systemic, rectal
8.5
6.8
14
18
N03AX09
ATC
lamotrigine; oral
5.9
6.8
18
34
N05AH02
ATC
clozapine; systemic
10.0
6.4
12
13
103
Kela drug reimbursment
Diabetes, insulin-treated
2.8
6.3
46
210
I20.90
ICD-10 Finland
Angina pectoris, unspecified
9.3
6.2
12
14
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.8
6.2
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
10
36.96
46.25
18.8
8.9
0.78
0.62
mmol/l
—
25
10
34
100
4.07
10.60
9.3
7.4
10.29
10.30
mmol/l
0.00
34
95
14
19
8.00
9.87
1.8
1.7
—
—
—
0
0
70
350
2.82
9.04
3.6
4.2
—
—
—
0
0
30
90
3.89
9.04
4.0
3.1
4.42
4.37
kpa
0.05
30
84
13
9
15.62
8.36
11.1
20.0
1850.69
1456.89
nmol/l
—
13
9
30
98
3.56
7.95
4.9
9.5
—
—
—
0
0
15
28
5.82
7.90
2.0
1.5
—
—
—
0
0
12
9
14.32
7.52
8.8
16.2
731.42
945.78
nmol/l
—
12
9
66
351
2.53
7.19
3.6
3.1
6.44
8.19
mmol/l
3.05
59
286
93
600
2.38
6.38
7.7
5.2
0.63
0.58
e9/l
1.10
80
517
93
601
2.37
6.34
7.2
5.2
0.03
0.04
e9/l
1.61
81
517
56
290
2.46
6.32
11.0
6.9
—
—
—
0
0
94
615
2.34
6.16
8.6
5.4
0.20
0.18
e9/l
0.40
84
538
12
23
5.57
6.11
2.2
2.1
—
—
—
0
0
73
431
2.31
6.08
6.2
3.1
—
—
—
0
0
55
287
2.42
6.07
2.9
2.0
3.19
3.13
mg/l
0.06
47
251
15
37
4.38
5.77
2.1
1.5
—
—
—
0
0
44
214
2.47
5.61
1.7
1.6
1154.44
1253.57
nmol/l
0.32
36
164
92
613
2.23
5.56
9.5
5.2
1.91
2.02
e9/l
0.21
80
541
58
322
2.28
5.47
4.2
2.8
—
—
—
0
0
15
39
4.15
5.40
2.1
1.5
—
—
—
0
0
15
39
4.15
5.40
2.3
1.5
—
—
—
0
0
15
39
4.15
5.40
2.1
1.5
—
—
—
0
0
19
59
3.53
5.37
3.6
2.7
1.23
1.39
%
0.21
19
59
19
59
3.53
5.37
2.1
3.1
4.40
4.57
pmol/l
0.29
19
49
61
351
2.22
5.24
4.5
4.2
11.00
10.00
mg/mmol
0.07
43
224
101
709
2.22
5.23
13.7
9.4
4.39
4.12
e9/l
0.68
90
611
85
560
2.15
5.15
7.4
5.2
57.19
57.96
%
0.21
76
528
85
562
2.13
5.08
8.6
5.5
8.56
8.70
%
0.12
77
533
86
572
2.13
5.05
8.2
5.4
26.68
27.04
%
0.10
75
539
58
331
2.20
5.05
3.9
3.2
1010.24
63.58
mg/l
0.49
41
221
77
495
2.10
4.91
8.9
8.2
1.06
1.23
inr
3.08
17
153
106
774
2.17
4.76
6.1
3.9
—
—
—
0
0
47
253
2.23
4.68
6.1
3.4
—
—
—
0
0
71
450
2.07
4.63
2.3
1.9
87.80
95.50
pmol/l
0.81
45
237
101
732
2.09
4.53
8.5
4.4
7.02
6.68
mmol/l
0.73
96
687
82
558
2.00
4.30
7.5
5.2
2.90
2.62
%
0.48
74
523
78
529
1.96
4.06
10.1
6.2
1.22
1.21
mmol/l
0.81
72
485
30
141
2.40
4.04
1.8
1.6
—
—
—
0
0
83
576
1.95
4.03
14.5
7.3
1.22
1.21
mmol/l
1.22
77
489
20
77
2.83
3.99
4.5
2.2
—
—
—
0
0
73
490
1.93
3.87
5.3
3.9
22.81
44.19
ng/l
1.65
52
358
13
39
3.55
3.85
2.5
1.4
—
—
—
0
0
62
396
1.94
3.80
6.2
5.0
—
—
—
0
0
51
308
1.98
3.65
5.1
2.9
0.16
0.45
e6/l
2.11
40
230
56
350
1.94
3.63
6.7
4.0
7.40
7.40
ph
—
5
68
55
342
1.94
3.61
5.6
3.0
108.73
48.55
e6/l
0.37
44
266
78
545
1.87
3.58
8.1
5.2
0.64
0.66
%
0.11
71
511
10
27
3.89
3.41
1.2
1.1
—
—
—
0
0
49
299
1.93
3.37
4.9
2.8
—
—
—
0
0
38
212
2.05
3.36
5.0
3.3
37.33
148.27
ng/l
1.85
30
166
14
49
3.04
3.29
13.3
4.7
—
—
—
0
0
7
11
6.60
3.22
1.6
1.8
—
—
—
0
0
27
134
2.23
3.20
1.5
1.3
—
—
—
0
0
60
398
1.83
3.16
6.7
3.4
95.67
81.37
e6/l
0.08
45
287
19
82
2.50
3.05
8.9
4.1
—
—
—
0
0
7
12
6.05
3.05
1.3
2.0
—
—
—
0
0
7
12
6.05
3.05
1.3
2.0
—
—
—
0
0
7
12
6.05
3.05
1.3
2.0
—
—
—
0
0
7
12
6.05
3.05
1.3
2.0
—
—
—
0
0
28
144
2.15
3.04
1.6
1.4
—
—
—
0
0
22
102
2.35
3.04
4.5
3.1
—
—
—
0
0
77
558
1.75
2.97
6.2
3.3
0.00
0.00
estimate
0.00
12
119
32
175
2.04
2.97
2.2
2.1
—
—
—
0
0
6
9
6.88
2.89
1.3
4.3
—
—
—
0
0
77
566
1.72
2.77
6.2
3.3
0.00
0.00
estimate
0.00
12
109
7
14
5.18
2.76
1.1
1.1
—
—
—
0
0
76
558
1.71
2.73
8.1
4.4
0.00
0.00
estimate
0.00
13
117
37
221
1.89
2.66
4.2
2.6
539.53
546.25
mosm/kgh2o
0.06
30
182
30
169
1.96
2.56
3.2
2.8
4.66
2.70
e6/l
0.22
20
90
17
79
2.29
2.35
9.1
10.2
0.84
0.68
%
1.39
17
79
17
80
2.26
2.28
9.1
10.1
1.71
1.64
%
0.10
17
80
15
67
2.37
2.26
7.1
8.6
24.10
24.87
mmol/l
0.28
15
67
7
19
3.81
2.17
2.0
3.6
—
—
—
0
0
24
133
1.95
2.14
2.2
4.8
3.11
87.53
ug/l
0.86
19
116
106
884
1.63
2.09
6.6
3.7
14.85
14.87
pmol/l
0.02
101
778
102
844
1.61
2.07
5.1
3.9
—
—
—
0
0
6
15
4.12
2.06
1.3
1.1
—
—
—
0
0
72
551
1.57
2.03
10.6
9.8
0.00
0.00
e9/l
0.70
58
446
7
21
3.44
1.99
1.1
1.4
—
—
—
0
0
6
16
3.86
1.95
1.2
1.4
—
—
—
0
0
12
52
2.42
1.93
2.4
4.2
—
—
—
0
0
28
170
1.79
1.90
3.7
2.4
2.39
2.31
g/l
0.23
28
160
40
270
1.65
1.87
8.0
5.1
—
—
—
0
0
6
17
3.63
1.85
1.2
1.1
—
—
—
0
0
6
17
3.63
1.85
1.3
1.2
—
—
—
0
0
26
156
1.80
1.84
1.9
1.6
—
—
—
0
0
30
441
0.60
1.69
4.8
3.0
—
—
—
0
0
45
322
1.56
1.65
7.1
3.5
0.00
0.00
estimate
0.00
12
111
49
358
1.54
1.64
5.7
4.1
—
—
—
0
0
45
329
1.52
1.49
2.7
2.9
368.23
4587.69
umol/l
1.05
39
284
30
200
1.62
1.47
2.4
1.8
—
—
—
0
0
34
234
1.58
1.46
1.9
1.8
522.38
487.63
pmol/l
0.13
26
193
5
16
3.19
1.45
1.6
3.1
—
—
—
0
0
6
22
2.79
1.45
4.7
2.7
—
—
—
0
0
6
23
2.67
1.38
5.5
1.7
—
—
—
0
0
5
17
3.00
1.37
2.2
2.6
57.60
66.68
%
—
5
17
19
114
1.76
1.36
1.3
1.6
—
—
—
0
0
21
131
1.70
1.32
1.9
1.6
—
—
—
0
0
35
250
1.52
1.28
1.8
1.8
0.87
1.19
mg/l
0.58
29
196
120
1088
1.46
1.14
7.8
4.4
1.81
1.96
mu/l
0.72
112
965
16
97
1.72
1.12
2.5
4.5
0.95
0.89
%
—
10
37
103
914
1.38
1.07
4.6
3.7
12.40
11.77
mm/h
0.19
95
834
35
260
1.45
1.06
1.3
1.3
0.76
1.32
u/ml
—
8
66
7
34
2.11
1.04
1.0
1.3
—
—
—
0
0
5
22
2.31
1.04
12.2
6.2
—
—
—
0
0
5
22
2.31
1.04
1.8
2.6
—
—
—
0
0
5
22
2.31
1.04
1.0
1.6
—
—
—
0
0
11
61
1.86
1.01
2.4
2.5
—
—
—
0
0
6
27
2.27
0.94
1.7
1.2
—
—
—
0
0
10
55
1.87
0.94
1.1
1.3
—
—
—
0
0
18
119
1.58
0.93
2.9
2.3
0.20
0.21
g/l
0.18
18
112
14
87
1.67
0.91
1.9
1.8
—
—
—
0
0
22
154
1.50
0.89
1.5
1.3
266.67
412.50
titre
—
6
32
14
88
1.65
0.88
2.6
4.7
0.00
0.23
%
—
8
31
31
238
1.38
0.79
1.7
1.4
1.72
2.48
g/l
2.86
19
137
13
83
1.62
0.77
1.4
1.4
—
—
—
0
0
13
83
1.62
0.77
1.4
1.5
—
—
—
0
0
9
53
1.74
0.77
2.2
3.4
16.89
240.73
u/ml
—
9
44
130
1223
1.39
0.75
26.9
13.9
24.13
24.30
mg/l
0.02
121
957
5
24
2.12
0.75
1.8
1.2
—
—
—
0
0
7
39
1.83
0.73
2.0
1.7
—
—
—
0
0
7
44
1.62
0.66
1.3
2.8
—
—
—
0
0
124
1168
1.31
0.63
6.7
4.5
6.25
5.97
mmol/l
0.86
117
1057
5
30
1.69
0.62
2.0
1.2
—
—
—
0
0
47
398
1.26
0.61
2.4
2.4
—
—
—
0
0
7
115
0.59
0.60
1.1
1.4
—
—
—
0
0
123
1160
1.29
0.60
5.2
3.9
1.56
1.28
mmol/l
2.45
117
1051
8
53
1.54
0.59
4.9
3.5
—
—
—
0
0
136
1302
1.36
0.57
31.6
16.3
93.62
80.59
umol/l
1.20
136
1302
118
1113
1.25
0.53
25.4
13.9
37.73
40.52
%
1.44
73
813
14
103
1.39
0.47
2.7
2.1
9.77
15.19
nmol/l
1.32
14
95
5
31
1.63
0.43
1.0
1.1
—
—
—
0
0
18
141
1.31
0.42
1.4
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
13
97
1.37
0.41
1.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
1.09
—
0
7
10
71
1.44
0.40
1.1
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
7.33
—
0
11
10
76
1.34
0.29
3.4
2.5
—
—
—
0
0
31
274
1.16
0.27
3.9
2.7
0.62
0.71
ug/l
0.45
24
166
11
87
1.28
0.25
3.1
4.7
0.00
0.31
%
—
6
29
5
37
1.36
0.24
2.6
4.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
25.41
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
14
117
1.22
0.21
15.0
5.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
0.14
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
131
1280
1.15
0.21
24.5
13.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
9
111
0.80
0.21
1.8
1.4
—
—
—
0
0
9
111
0.80
0.21
5.4
3.4
—
—
—
0
0
21
185
1.16
0.19
1.2
1.3
0.89
11.70
u/ml
—
7
76
34
313
1.11
0.17
1.9
1.7
1.55
1.38
mmol/l
0.47
29
258
23
208
1.12
0.15
1.1
1.3
11.74
27.70
iu/ml
—
8
65
30
325
0.90
0.15
1.3
1.4
—
—
—
0
0
31
329
0.93
0.10
5.4
2.9
—
—
—
0
0
51
493
1.05
0.07
6.4
4.4
3.40
1.87
ug/l
1.40
46
435
137
1366
1.03
0.00
42.6
20.4
133.53
136.66
g/l
1.64
137
1345
12
119
1.01
0.00
1.6
1.4
—
—
—
0
0
18
181
0.99
0.00
1.1
1.3
—
—
—
0
0
49
488
1.01
0.00
2.5
2.0
—
—
—
0
0
137
1365
1.03
0.00
42.3
20.2
30.40
30.39
pg
0.01
137
1345
137
1365
1.03
0.00
42.4
20.2
92.10
91.09
fl
1.39
137
1345
0
8
0.00
0.00
0.0
4.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
5.0
12.5
—
—
—
0
0
6
65
0.92
0.00
2.3
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
27.60
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
6.67
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
2.07
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
9
95
0.94
0.00
9.7
4.8
1.23
1.22
mmol/l
—
9
85
0
7
0.00
-0.00
0.0
1.4
—
270.94
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: R18_FINDI_DRUGS_OTHER_SUBST_NOT_NORMALLY_FOUND_BLOOD – Findings of drugs and other substances, not normally found in blood

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).