Streptococcus and staphylococcus as the cause of diseases classified to other chapters

AB1_STREPTSTAPHYCOCC_INOTHER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B95
  • Cause of death: ICD-10 B95

2 out of 7 registries used, show all original rules.

213

4. Check minimum number of events

None

213

5. Include endpoints

None

213

6. Filter based on genotype QC (FinnGen only)

201

Control definitions (FinnGen only)

Control exclude
AB1_BACT_BIR_OTHER_INF_AGENTS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2560 1085 1457
Only index persons 1924 822 1102
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.04 0.03 0.04
Median age at first event (years)
Whole population 38.73 37.89 39.06
Only index persons 40.34 40.80 39.99

-FinnGen-

Key figures

All Female Male
Number of individuals 201 82 119
Unadjusted period prevalence (%) 0.04 0.03 0.05
Median age at first event (years) 56.22 55.16 56.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
213
Matched controls
2130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B95.6
ICD-10 Finland
Staphylococcus aureus as the cause of diseases classified to other chapters
+∞
84.0
75
*
B95.0
ICD-10 Finland
Streptococcus, group A, as the cause of diseases classified to other chapters
+∞
33.2
31
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.8
27.9
63
143
J01FF01
ATC
clindamycin; systemic
4.6
27.1
109
396
A41.9
ICD-10 Finland
Sepsis, unspecified
9.4
24.1
31
38
B95.4
ICD-10 Finland
Other streptococcus as the cause of diseases classified to other chapters
+∞
23.4
22
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.1
22.4
37
61
B95.7
ICD-10 Finland
Other staphylococcus as the cause of diseases classified to other chapters
+∞
22.3
21
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.5
20.2
31
47
ZXD05
NOMESCO Finland
Urgent procedure
3.7
19.4
104
441
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
60.9
19.3
22
*
B95.3
ICD-10 Finland
Streptococcus pneumoniae as the cause of diseases classified to other chapters
+∞
19.0
18
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
19.9
18.8
28
16
A46
ICD-10 Finland
Erysipelas
4.2
18.6
61
184
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.7
18.4
38
78
J04AB02
ATC
rifampicin; systemic
34.8
17.4
22
7
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
7.5
17.0
26
39
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.6
16.8
46
120
C03CA01
ATC
furosemide; systemic
3.3
16.5
99
440
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.4
15.7
24
36
J01MA12
ATC
levofloxacin; systemic
3.6
15.3
65
232
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
15.1
62
216
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
14.9
105
506
B95.5
ICD-10 Finland
Unspecified streptococcus as the cause of diseases classified to other chapters
+∞
14.8
14
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
14.7
64
231
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.3
14.0
70
275
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
13.8
51
165
R50.9
ICD-10 Finland
Fever, unspecified
3.6
13.6
56
194
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
13.4
60
219
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.8
12.7
31
73
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
12.3
42
128
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.2
12.0
26
55
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
20.4
11.8
17
9
Z2446
NOMESCO Finland
Social worker
4.3
11.7
33
87
J01CF02
ATC
cloxacillin; systemic
11.5
11.6
21
20
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
11.1
75
343
TK800
NOMESCO Finland
Hemodialysis
12.9
11.1
19
16
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.9
11.1
19
16
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
5.0
11.0
25
55
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.7
10.8
21
40
127
Kela drug reimbursment
Transplant complication
15.3
10.7
17
12
Z49.1
ICD-10 Finland
Extracorporeal dialysis
34.4
10.5
13
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.6
10.4
26
62
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
8.6
10.4
22
28
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
9.9
10.3
20
22
J01MA02
ATC
ciprofloxacin; systemic
2.5
10.1
103
573
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.5
10.0
20
23
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
9.8
100
555
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.3
9.7
27
70
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
57.7
9.7
11
*
B01AA03
ATC
warfarin; systemic
2.8
9.7
60
260
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
9.3
41
146
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.2
9.3
26
68
M46.4
ICD-10 Finland
Discitis, unspecified
38.5
9.1
11
*
ZXA00
NOMESCO Finland
Right side
2.6
9.1
73
360
L04AA01
ATC
[U] ciclosporin
19.7
9.0
13
7
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
19.7
9.0
13
7
Z94.0
ICD-10 Finland
Kidney transplant status
25.3
9.0
12
5
ZXE00
NOMESCO Finland
One hour or less
2.4
9.0
102
588
J01MA14
ATC
moxifloxacin; systemic
3.6
8.9
32
100
J01CF05
ATC
flucloxacillin; systemic
4.0
8.9
27
75
WW200
NOMESCO Finland
Immunization
8.2
8.9
19
25
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
8.9
64
299
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
52.2
8.8
10
*
A10AC01
ATC
insulin (human); parenteral
3.4
8.7
34
112
WX892
NOMESCO Finland
Monitored bed care
3.9
8.7
27
76
N18.8
ICD-10 Finland
Other chronic renal failure
9.6
8.7
17
19
EBA15
NOMESCO Finland
Extraction of multiple teeth
7.9
8.7
19
26
Z3226
NOMESCO Finland
Physiotherapist
2.7
8.6
57
254
Z3231
NOMESCO Finland
Registered nurse
2.4
8.6
81
429
Z50.1
ICD-10 Finland
Other physical therapy
5.0
8.5
19
41
B95.1
ICD-10 Finland
Streptococcus, group B, as the cause of diseases classified to other chapters
+∞
8.4
8
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
8.4
37
132
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
8.2
35
122
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
8.2
46
188
V03AE01
ATC
polystyrene sulfonate; oral
18.0
8.2
12
7
QDB99
NOMESCO Finland
Other procedure for wound of skin of lower limb
34.8
8.1
10
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
23.1
8.1
11
5
TQW11
NOMESCO Finland
Vacuum treatment of wound
8.3
8.0
17
22
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.5
8.0
18
26
A12AA04
ATC
calcium carbonate; oral
11.4
7.9
14
13
B01AB05
ATC
enoxaparin; parenteral
2.3
7.8
79
428
L04AX01
ATC
azathioprine; systemic
4.8
7.8
18
40
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
7.2
7.8
18
27
V03AE02
ATC
sevelamer; oral
46.7
7.8
9
*
R4110
NOMESCO Finland
Physiotherapy
2.3
7.6
76
409
A11CC03
ATC
alfacalcidol; systemic
7.8
7.3
16
22
B95.2
ICD-10 Finland
Streptococcus group D and enterococcus as the cause of diseases classified to other chapters
+∞
7.3
7
*
L04AD01
ATC
ciclosporin; systemic
10.6
7.1
13
13
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.9
7.1
36
139
B99
ICD-10 Finland
Other and unspecified infectious diseases
8.0
7.0
15
20
Z2221
NOMESCO Finland
Medical doctor
2.3
7.0
72
391
L89
ICD-10 Finland
Decubitus ulcer and pressure area
11.5
6.9
12
11
WX002
NOMESCO Finland
Sedation and analgesia
2.5
6.9
53
253
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
41.4
6.8
8
*
ZXA05
NOMESCO Finland
Left side
2.3
6.8
65
341
N18.0
ICD-10 Finland
End-stage renal disease
23.4
6.7
9
*
WW500
NOMESCO Finland
Blood transfusion
4.1
6.7
19
50
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
5.7
6.6
18
34
L04AA06
ATC
mycophenolic acid; systemic
10.5
6.6
12
12
C09AA02
ATC
enalapril; systemic
2.4
6.6
54
264
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.5
68
369
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
6.5
70
385
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.0
6.4
30
110
NHQ40
NOMESCO Finland
Amputation of toe
8.6
6.4
13
16
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.8
6.3
20
57
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
18.7
6.3
9
5
C03DA01
ATC
spironolactone; oral
2.7
6.3
37
154
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
27.6
6.3
8
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.3
6.3
24
78
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
6.3
29
106
B03XA02
ATC
darbepoetin alfa; parenteral
8.1
6.2
13
17
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.0
6.1
10
8
A10AA02, ,
ATC
3.9
6.1
18
49
SPAT1255
SPAT
Intravenous administration of medicine
3.5
6.0
21
64
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.8
6.0
19
54
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.3
6.0
17
34

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
242
4.79
25.80
3.4
2.2
—
—
—
0
0
39
73
6.32
20.84
2.0
2.1
1.67
1.59
g/l
0.14
33
60
64
199
4.17
18.70
3.2
1.6
—
—
—
0
0
70
289
3.12
12.72
9.9
3.9
0.78
0.82
mmol/l
1.74
65
272
94
464
2.84
12.27
12.0
4.2
—
—
—
0
0
46
160
3.39
10.96
13.5
9.1
—
—
—
0
0
51
192
3.18
10.67
5.0
3.2
2.24
1.67
%
2.51
44
177
48
175
3.25
10.58
12.0
4.0
5.62
5.71
kpa
0.28
48
169
62
263
2.91
10.51
5.0
2.3
20.26
24.02
%
1.00
56
231
63
284
2.73
9.42
3.0
1.7
—
—
—
0
0
76
387
2.50
8.78
3.0
2.1
2.94
3.03
mg/l
0.11
66
342
82
436
2.43
8.59
25.9
7.3
—
—
—
0
0
115
712
2.34
8.47
13.0
4.9
33.31
35.77
g/l
3.26
110
667
111
688
2.28
8.02
5.2
2.6
147.49
129.39
ug/l
0.37
101
634
132
894
2.25
7.51
15.6
6.1
1.64
1.93
e9/l
2.91
124
788
87
503
2.23
7.28
6.0
2.4
—
—
—
0
0
120
791
2.18
7.19
28.9
13.9
1.54
1.26
inr
1.54
34
242
18
31
6.24
7.09
7.3
3.0
—
—
—
0
0
56
271
2.45
7.04
4.3
2.0
31.59
29.51
s
1.74
56
266
17
41
4.42
6.68
2.6
4.1
—
—
—
0
0
127
873
2.13
6.63
15.8
6.0
0.62
0.58
e9/l
0.91
119
752
127
875
2.12
6.57
15.8
6.0
0.04
0.04
e9/l
0.63
119
755
40
173
2.62
6.32
3.2
2.5
31.11
35.78
u/l
0.30
35
146
121
827
2.07
6.30
16.4
6.6
—
—
—
0
0
128
899
2.06
6.12
17.5
6.4
0.21
0.19
e9/l
0.28
120
789
23
78
3.18
5.61
5.5
2.9
0.55
0.66
%
0.74
23
78
78
470
2.04
5.58
5.1
2.9
—
—
—
0
0
43
204
2.39
5.57
1.7
1.6
—
—
—
0
0
80
488
2.02
5.53
5.4
3.0
0.67
0.45
e6/l
0.33
67
369
36
158
2.54
5.50
9.2
7.5
1.33
1.41
mmol/l
0.12
36
151
18
53
3.62
5.44
5.1
2.6
—
—
—
0
0
46
230
2.28
5.27
2.5
1.6
—
—
—
0
0
72
431
2.01
5.19
11.7
4.3
84.38
87.91
%
0.50
72
424
13
23
5.95
5.15
7.2
2.2
64.08
59.20
%
0.24
13
23
75
466
1.94
4.80
3.9
3.1
—
—
—
0
0
54
299
2.08
4.77
1.8
1.7
1144.21
1240.46
nmol/l
0.27
42
231
30
129
2.54
4.77
2.5
1.5
—
—
—
0
0
41
204
2.25
4.73
7.2
10.3
-2.35
1.12
mmol/l
3.01
32
167
105
732
1.86
4.69
14.9
7.1
1.19
1.21
mmol/l
1.29
94
671
9
11
8.48
4.61
1.4
1.3
163.83
193.40
iu/ml
—
9
11
51
281
2.07
4.55
3.9
2.9
1.50
1.87
e6/l
0.22
31
157
82
534
1.87
4.50
6.3
3.2
831.78
169.50
e6/l
0.40
69
415
57
329
2.00
4.47
6.8
3.9
307.91
267.34
ng/l
0.07
46
263
64
388
1.93
4.35
1.7
1.5
19.01
20.40
nmol/l
0.32
55
323
11
20
5.74
4.35
1.7
1.2
—
—
—
0
0
112
814
1.79
4.23
18.9
7.6
1.20
1.21
mmol/l
0.63
98
698
11
21
5.46
4.20
1.3
1.4
—
—
—
0
0
23
93
2.65
4.13
8.5
14.6
—
—
—
0
0
26
112
2.51
4.11
2.4
1.9
—
—
—
0
0
17
58
3.10
4.11
2.4
1.2
—
—
—
0
0
14
36
4.09
4.08
3.1
1.6
—
—
—
0
0
89
610
1.79
4.05
7.2
3.9
80.39
62.32
e6/l
0.21
71
439
11
23
4.98
3.93
2.5
2.8
—
—
—
0
0
132
1020
1.77
3.92
25.0
9.7
3.87
4.13
e9/l
0.75
126
887
75
495
1.80
3.84
13.3
4.1
7.40
7.40
ph
0.18
12
82
91
641
1.73
3.69
2.4
1.9
79.39
96.19
pmol/l
3.49
54
332
12
31
4.04
3.55
1.1
1.2
—
—
—
0
0
7
10
7.19
3.39
4.6
2.7
1229.43
732.00
u/ml
—
7
10
104
773
1.67
3.38
22.6
9.6
0.00
0.00
e9/l
0.16
89
623
57
359
1.80
3.35
5.4
3.0
538.62
573.59
mosm/kgh2o
0.77
52
303
10
23
4.51
3.35
1.6
1.2
—
—
—
0
0
15
54
2.91
3.33
1.4
1.2
—
—
—
0
0
11
29
3.94
3.23
1.2
1.0
—
—
—
0
0
12
35
3.57
3.16
1.2
1.1
—
—
—
0
0
9
20
4.65
3.15
2.3
2.2
37.88
32.76
%
—
9
20
132
1058
1.65
3.10
6.3
4.4
—
337.14
—
0
22
8
16
5.15
3.08
3.9
2.7
—
—
—
0
0
7
13
5.53
2.89
4.3
3.0
—
—
—
0
0
36
205
1.91
2.88
3.0
1.6
—
—
—
0
0
8
18
4.57
2.82
1.9
1.2
—
—
—
0
0
9
23
4.04
2.81
4.1
3.8
55.11
58.43
%
—
9
23
54
356
1.69
2.67
1.9
1.5
2.78
2.63
g/l
0.20
37
217
7
15
4.79
2.62
1.3
1.1
—
—
—
0
0
9
25
3.71
2.60
3.3
2.0
—
—
—
0
0
24
425
0.51
2.54
2.9
2.9
1.92
0.73
ug/l
0.42
16
276
8
21
3.91
2.49
4.4
3.1
5.58
4.44
e9/l
—
8
21
9
27
3.43
2.42
1.9
1.4
—
—
—
0
0
53
359
1.63
2.35
3.3
1.8
2.09
1.24
mg/l
0.44
45
273
72
528
1.55
2.28
7.0
3.1
2.33
2.35
mmol/l
0.56
65
459
7
18
3.98
2.27
1.0
1.2
—
—
—
0
0
5
9
5.66
2.22
1.0
1.2
—
—
—
0
0
22
116
2.00
2.20
10.1
7.6
22.71
24.71
mmol/l
0.97
22
116
7
19
3.77
2.17
2.7
1.2
—
—
—
0
0
10
36
2.86
2.17
4.8
2.0
—
—
—
0
0
9
31
2.98
2.10
2.0
2.0
—
11313.60
—
0
8
5
10
5.09
2.08
1.0
1.4
—
—
—
0
0
12
50
2.48
2.06
1.4
1.1
—
—
—
0
0
8
26
3.16
2.03
3.5
3.9
—
—
—
0
0
10
38
2.71
2.03
1.9
1.4
—
—
—
0
0
5
11
4.63
1.95
1.0
1.1
—
—
—
0
0
151
1676
0.66
1.94
5.2
4.9
2.51
2.72
mmol/l
1.94
136
1540
149
1302
1.48
1.85
20.7
7.9
95.87
81.41
u/l
2.31
142
1219
25
148
1.78
1.80
7.5
4.3
0.69
0.83
%
0.20
13
57
16
81
2.05
1.80
1.6
1.2
—
—
—
0
0
7
24
2.98
1.73
3.3
2.4
107.14
106.79
mmol/l
—
7
24
7
24
2.98
1.73
3.3
2.4
3.96
3.94
mmol/l
—
7
24
7
24
2.98
1.73
3.3
2.4
—
—
—
0
0
5
13
3.91
1.72
1.0
1.0
—
—
—
0
0
23
135
1.79
1.71
7.2
4.4
0.09
0.16
%
0.26
11
43
22
128
1.80
1.68
7.3
4.3
0.60
0.53
%
—
10
39
54
397
1.48
1.64
3.1
3.6
—
—
—
0
0
148
1633
0.69
1.62
4.7
4.4
1.32
1.41
mmol/l
1.70
131
1497
8
166
0.46
1.55
1.3
1.3
—
—
—
0
0
7
27
2.65
1.53
1.1
1.4
—
—
—
0
0
7
28
2.55
1.46
9.9
2.0
—
—
—
0
0
33
226
1.54
1.40
1.1
1.3
—
—
—
0
0
5
17
2.99
1.36
2.2
1.7
—
—
—
0
0
22
137
1.68
1.36
8.4
4.4
—
—
—
0
0
47
612
0.70
1.32
3.1
2.9
—
—
—
0
0
20
123
1.69
1.29
3.1
8.0
—
—
—
0
0
9
44
2.09
1.28
1.1
1.4
—
60.00
—
0
7
146
1595
0.73
1.28
4.7
4.5
6.24
6.00
mmol/l
1.00
130
1457
144
1576
0.73
1.27
4.4
4.0
1.38
1.30
mmol/l
0.64
128
1444
13
70
1.91
1.27
1.0
1.2
—
—
—
0
0
15
85
1.82
1.26
4.7
4.5
—
—
—
0
0
179
1890
0.67
1.26
55.7
21.0
37.24
40.58
%
6.00
166
1779
151
1640
0.73
1.26
4.8
4.5
4.32
4.56
mmol/l
2.02
137
1518
20
126
1.65
1.19
1.2
1.2
—
—
—
0
0
14
80
1.80
1.16
2.7
2.3
—
—
—
0
0
12
66
1.87
1.11
3.3
12.0
2.54
1.55
%
1.01
12
61
34
455
0.70
1.11
6.6
3.5
—
—
—
0
0
9
46
2.00
1.05
1.6
1.5
—
—
—
0
0
15
91
1.70
1.03
8.5
4.3
—
—
—
0
0
9
47
1.95
1.03
3.9
16.1
1.19
1.22
mmol/l
—
9
42
16
100
1.65
1.00
5.4
2.5
—
—
—
0
0
7
36
1.98
0.98
2.7
1.2
—
—
—
0
0
9
51
1.80
0.96
4.0
5.6
—
—
—
0
0
6
27
2.26
0.94
1.0
1.6
—
—
—
0
0
141
1523
0.78
0.92
8.0
5.9
42.69
40.41
mmol/mol
1.22
127
1418
57
469
1.29
0.87
5.4
3.3
1212.05
313.92
mg/l
0.38
42
322
8
44
1.85
0.87
1.8
1.6
—
—
—
0
0
31
233
1.39
0.86
1.5
1.4
417.78
373.06
titre
—
9
49
60
499
1.28
0.84
6.5
3.9
22.88
7.93
mg/mmol
1.14
44
331
126
1143
1.25
0.84
6.7
4.1
—
—
—
0
0
18
122
1.52
0.83
2.7
1.5
—
—
—
0
0
6
32
1.90
0.82
1.0
1.4
—
—
—
0
0
60
504
1.27
0.78
5.5
3.2
6.89
8.01
mmol/l
1.22
50
428
27
202
1.39
0.77
1.2
1.2
—
—
—
0
0
7
38
1.87
0.74
3.4
2.3
—
—
—
0
0
23
170
1.40
0.71
1.7
1.4
—
—
—
0
0
9
58
1.58
0.70
1.7
2.7
—
—
—
0
0
10
61
1.67
0.70
2.0
1.4
—
—
—
0
0
61
702
0.82
0.64
4.0
4.8
2.91
2.46
ug/l
0.10
53
626
10
63
1.62
0.63
2.0
1.4
—
—
—
0
0
5
30
1.68
0.62
5.4
2.7
7.94
8.65
kpa
—
5
30
5
30
1.68
0.62
7.8
2.2
—
—
—
0
0
5
30
1.68
0.62
5.4
2.7
4.82
4.93
kpa
—
5
30
5
30
1.68
0.62
1.0
1.2
—
—
—
0
0
135
1257
1.20
0.61
7.3
4.2
16.55
11.30
mm/h
2.84
124
1146
10
64
1.59
0.59
2.0
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
3.7
—
—
—
0
0
41
342
1.25
0.57
1.9
1.8
363.03
441.04
pmol/l
1.54
36
296
18
133
1.39
0.57
8.2
4.4
0.00
0.24
%
—
5
41
10
65
1.56
0.56
2.0
1.4
—
—
—
0
0
10
65
1.56
0.56
2.0
1.4
—
—
—
0
0
171
1778
0.81
0.56
27.4
13.2
—
—
—
0
0
173
1795
0.81
0.54
24.6
10.6
28.95
27.13
u/l
0.70
167
1728
9
62
1.47
0.54
1.6
1.9
—
—
—
0
0
52
457
1.18
0.44
4.0
4.0
—
—
—
0
0
128
1206
1.15
0.44
3.9
3.8
14.49
14.77
pmol/l
0.53
118
1089
31
366
0.82
0.42
3.9
4.2
1.01
1.02
kg/l
—
7
50
0
17
0.00
0.41
0.0
3.1
—
—
—
0
0
15
115
1.33
0.40
1.4
1.2
—
25.44
—
0
7
69
626
1.15
0.39
2.3
2.0
—
—
—
0
0
90
832
1.14
0.39
6.7
5.1
0.00
0.00
estimate
-0.00
12
156
0
19
0.00
0.39
0.0
6.3
—
7.44
—
0
5
42
367
1.18
0.38
1.5
1.4
0.74
0.83
u/ml
—
7
92
173
1674
1.18
0.38
43.4
14.7
28.13
23.60
mg/l
1.22
158
1318
6
42
1.44
0.36
6.2
1.9
0.45
0.70
nmol/l
—
6
35
6
44
1.37
0.34
1.3
1.1
—
—
—
0
0
90
840
1.12
0.33
4.9
3.8
0.00
0.00
estimate
-0.00
15
146
89
832
1.12
0.32
4.6
3.7
0.00
0.00
estimate
-0.00
15
164
49
441
1.14
0.31
1.8
1.7
1.64
1.36
mmol/l
0.68
40
373
16
131
1.24
0.28
6.2
3.5
—
—
—
0
0
13
104
1.27
0.27
1.2
1.3
92.46
132.11
iu/ml
—
5
37
8
66
1.22
0.27
4.8
5.5
—
—
—
0
0
5
74
0.67
0.26
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
0.97
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
13.4
—
819.21
—
0
14
0
14
0.00
0.20
0.0
20.6
—
1293.86
—
0
14
41
445
0.90
0.20
4.5
4.0
0.00
0.01
estimate
0.50
13
145
21
186
1.14
0.17
1.3
1.3
—
—
—
0
0
46
430
1.09
0.16
1.7
1.4
—
—
—
0
0
121
1177
1.06
0.14
5.6
3.8
—
—
—
0
0
19
171
1.12
0.13
1.9
1.4
—
—
—
0
0
30
278
1.09
0.13
1.2
1.3
4.01
8.83
u/ml
0.63
15
108
5
44
1.14
0.10
1.4
1.4
—
329.33
—
0
21
16
146
1.10
0.08
1.7
1.4
—
—
—
0
0
67
663
1.02
0.01
3.6
3.9
36.31
41.81
ng/l
0.19
49
464
12
124
0.97
0.00
1.4
1.3
—
—
—
0
0
149
1491
1.00
0.00
4.9
4.5
1.91
1.92
mu/l
0.04
137
1352
15
153
0.98
0.00
1.3
1.6
—
—
—
0
0
114
1145
0.99
0.00
4.3
3.3
82.14
49.24
u/l
1.41
104
1072
14
138
1.02
0.00
2.6
3.8
—
—
—
0
0
29
292
0.99
0.00
1.3
1.3
18.70
34.37
iu/ml
—
9
99
0
6
0.00
0.00
0.0
1.3
—
94.42
—
0
6
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
4.2
—
—
—
0
0
7
79
0.88
0.00
1.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.6
1.7
129.60
267.12
pmol/l
—
5
49
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
83
0.96
-0.00
1.5
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
4.48
—
0
9
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
4.33
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
1.57
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
38.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_STREPTSTAPHYCOCC_INOTHER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_STREPTSTAPHYCOCC_INOTHER 2.548 [1.94, 3.35] < 0.001
Birth year 0.997 [0.99, 1.01] 0.489

During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 872 females with AB1_STREPTSTAPHYCOCC_INOTHER died.

Males

Parameter HR [95% CI] p-value
AB1_STREPTSTAPHYCOCC_INOTHER 3.059 [2.4, 3.9] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 1147 males with AB1_STREPTSTAPHYCOCC_INOTHER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_STREPTSTAPHYCOCC_INOTHER.

N-year risk Females Males
1 0.3% 0.628%
5 1.742% 3.201%
10 4.149% 8.239%
15 7.55% 15.117%
20 13.582% 24.671%

Relationships between endpoints

Index endpoint: AB1_STREPTSTAPHYCOCC_INOTHER – Streptococcus and staphylococcus as the cause of diseases classified to other chapters

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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