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Carcinoma in situ of uteri, other/unspecified

CD2_INSITU_CERVIX_UTERI_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06.7&, D06.9&
  • Hospital discharge: ICD-9 2331
  • Cause of death: ICD-10 D06.7&, D06.9&
  • Cause of death: ICD-9 2331

2 out of 7 registries used, show all original rules.

227

4. Check minimum number of events

None

227

5. Include endpoints

None

227

6. Filter based on genotype QC (FinnGen only)

227

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 227 227 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 35.79 35.79 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
212
Matched controls
2118
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
594.3
160.9
141
7
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
+∞
138.1
117
*
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
109.0
95
*
8326
FHL
Batch conization
415.6
63.0
60
*
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
194.3
32.7
33
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
10.5
30.6
64
84
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
6.9
29.8
87
193
ULA02
NOMESCO Finland
Kolposcopy
6.6
29.2
89
208
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
14.7
23.5
40
33
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.4
19.0
48
81
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.5
18.7
80
253
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
43.9
16.6
20
5
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
5.0
15.2
53
133
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
+∞
14.8
14
*
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
+∞
13.7
13
*
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
8.4
8
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
7.6
7.6
17
24
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
82.9
7.5
8
*
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
41.4
6.8
8
*
ZXC00
NOMESCO Finland
Use of diathermy
13.0
6.1
10
8

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
38
4.16
5.53
2.3
1.9
—
—
—
0
0
12
31
4.03
4.31
1.2
1.7
—
—
—
0
0
15
60
2.61
2.76
9.7
5.7
—
—
—
0
0
79
571
1.59
2.68
1.8
2.1
—
—
—
0
0
0
57
0.00
2.08
0.0
1.1
—
—
—
0
0
13
57
2.36
2.02
1.3
1.4
—
—
—
0
0
13
57
2.36
2.02
1.3
1.4
—
—
—
0
0
13
57
2.36
2.02
1.3
1.4
—
—
—
0
0
13
57
2.36
2.02
1.3
1.4
—
—
—
0
0
17
84
2.11
2.01
8.2
2.9
—
—
—
0
0
5
11
4.62
1.95
5.8
6.3
—
—
—
0
0
27
428
0.58
1.91
1.2
1.3
1.9
2.1
g/l
0.93
18
261
60
438
1.50
1.88
3.2
3.5
—
—
—
0
0
10
214
0.44
1.79
2.5
1.4
—
—
—
0
0
25
155
1.69
1.54
3.1
3.4
—
—
—
0
0
5
15
3.38
1.53
1.0
1.0
—
—
—
0
0
177
1902
0.68
1.49
5.4
5.1
1.7
2.4
mu/l
0.59
169
1775
134
1502
0.74
1.43
7.2
6.9
77.5
77.0
u/l
0.06
129
1402
8
165
0.47
1.42
3.9
3.9
—
—
—
0
0
16
90
1.84
1.37
1.8
1.8
—
—
—
0
0
0
40
0.00
1.34
0.0
1.2
—
—
—
0
0
35
483
0.67
1.33
1.3
1.3
2.1
2.1
u/ml
0.00
11
138
9
43
2.14
1.32
1.3
1.3
—
—
—
0
0
56
706
0.73
1.27
1.9
1.8
91.7
100.5
pmol/l
0.92
30
342
9
169
0.51
1.24
1.1
1.1
—
—
—
0
0
168
1806
0.73
1.22
12.6
12.5
38.7
39.6
%
0.72
134
1397
6
127
0.46
1.21
4.3
2.1
67.3
67.4
g/l
—
6
118
8
38
2.14
1.19
5.5
3.7
—
—
—
0
0
0
33
0.00
1.17
0.0
5.9
—
40.8
—
0
28
0
33
0.00
1.17
0.0
1.2
—
—
—
0
0
186
1963
0.71
1.13
11.2
11.5
18.6
19.3
mg/l
0.12
146
1496
19
287
0.63
1.11
2.1
1.5
—
—
—
0
0
10
177
0.54
1.07
2.7
1.8
—
—
—
0
0
22
314
0.67
1.00
1.8
1.3
275.6
485.8
titre
—
9
69
27
192
1.46
0.98
1.6
1.5
—
—
—
0
0
181
1910
0.74
0.98
4.2
4.2
5.9
5.7
mmol/l
0.67
169
1787
0
30
0.00
0.98
0.0
1.6
—
—
—
0
0
79
918
0.79
0.95
5.8
5.6
30.1
29.3
%
0.24
74
855
85
979
0.79
0.94
6.6
5.6
2.0
1.9
e9/l
0.26
78
870
9
52
1.76
0.93
1.3
1.4
—
—
—
0
0
45
560
0.76
0.91
5.8
3.1
—
—
—
0
0
6
30
2.03
0.87
1.0
1.0
—
0.3
—
0
7
88
763
1.25
0.86
4.1
3.2
—
—
—
0
0
75
639
1.26
0.86
3.1
3.1
196.0
20.2
ng/l
0.79
34
378
6
31
1.96
0.85
3.7
2.5
7.7
7.5
mmol/l
—
6
31
201
2080
0.71
0.83
13.7
13.2
67.1
67.7
umol/l
0.24
201
2080
20
140
1.47
0.80
1.5
1.2
—
—
—
0
0
6
33
1.84
0.79
3.7
2.5
1.4
1.3
mmol/l
—
6
33
0
25
0.00
0.79
0.0
6.7
—
—
—
0
0
51
613
0.78
0.79
5.9
5.4
—
—
—
0
0
0
27
0.00
0.78
0.0
1.9
—
—
—
0
0
85
963
0.81
0.77
6.0
5.6
0.0
0.0
e9/l
0.21
76
832
191
1987
0.76
0.76
12.2
12.4
3.9
3.9
mmol/l
0.31
186
1933
9
56
1.63
0.73
6.3
4.2
—
—
—
0
0
172
1809
0.80
0.72
5.3
5.0
39.0
38.6
mmol/mol
0.23
161
1700
85
957
0.82
0.72
5.8
5.6
0.5
0.5
e9/l
0.23
76
831
19
135
1.44
0.71
3.4
2.8
—
—
—
0
0
191
1984
0.76
0.71
12.1
12.3
139.8
139.9
mmol/l
0.13
186
1932
7
120
0.57
0.69
1.0
1.6
1.5
1.5
g/l
—
7
109
90
1004
0.83
0.68
5.8
5.9
0.2
0.2
e9/l
1.54
80
893
7
44
1.61
0.65
2.3
2.0
—
—
—
0
0
18
130
1.42
0.63
3.3
2.9
3.0
2.5
mmol/l
0.25
12
106
140
1494
0.84
0.62
3.8
4.0
11.6
10.6
mm/h
0.42
134
1378
9
141
0.62
0.62
2.3
3.1
48.8
71.9
ng/l
—
9
125
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
13
184
0.69
0.59
1.1
1.3
168.7
153.2
iu/ml
—
7
85
20
150
1.37
0.58
5.3
3.3
4.6
4.6
pmol/l
0.08
20
133
6
35
1.73
0.58
1.5
1.6
—
—
—
0
0
10
147
0.67
0.55
1.2
2.5
10.9
10.0
g/l
—
10
137
48
410
1.22
0.54
1.2
1.3
28.6
31.8
iu/ml
0.09
21
139
9
132
0.67
0.53
2.2
1.3
—
—
—
0
0
14
191
0.72
0.53
4.4
4.2
1.0
1.1
mmol/l
0.13
14
172
112
1032
1.17
0.53
3.1
3.9
6.6
6.4
mmol/l
0.52
106
958
125
1337
0.86
0.53
4.7
4.0
—
—
—
0
0
28
225
1.28
0.52
1.7
1.8
—
—
—
0
0
103
1117
0.86
0.52
10.4
9.3
3.9
3.9
e9/l
0.14
92
971
21
163
1.32
0.50
1.4
1.4
—
—
—
0
0
12
84
1.45
0.50
4.1
8.4
91.9
94.9
%
1.06
12
84
106
978
1.16
0.48
6.8
4.8
0.0
0.0
estimate
0.00
16
188
12
165
0.71
0.48
2.4
2.4
—
9.6
—
0
5
86
782
1.16
0.47
2.7
2.7
—
—
—
0
0
34
402
0.82
0.46
1.4
1.4
22.3
22.5
nmol/l
0.02
29
330
49
558
0.84
0.45
1.5
1.7
1.5
1.4
mmol/l
0.30
41
475
5
31
1.63
0.43
1.4
1.4
—
—
—
0
0
6
94
0.63
0.43
1.3
1.1
—
—
—
0
0
106
986
1.14
0.42
4.6
3.5
0.0
0.0
estimate
0.80
15
184
158
1647
0.87
0.42
4.4
4.4
14.8
14.5
pmol/l
0.61
149
1529
0
15
0.00
0.41
0.0
1.1
—
33.0
—
0
15
0
15
0.00
0.41
0.0
2.7
—
51.9
—
0
8
52
584
0.86
0.40
2.8
2.2
49.6
56.7
u/l
1.11
46
540
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.8
—
—
—
0
0
142
1351
1.14
0.38
3.2
3.3
—
—
—
0
0
58
520
1.15
0.38
1.4
1.4
—
—
—
0
0
19
234
0.79
0.38
1.2
1.3
—
—
—
0
0
69
628
1.14
0.37
3.5
3.2
9.9
61.2
e6/l
3.99
51
415
5
78
0.63
0.36
1.0
1.2
—
—
—
0
0
12
156
0.76
0.36
3.1
3.5
—
—
—
0
0
56
506
1.14
0.33
4.2
3.6
3.9
8.1
mg/mmol
0.79
34
285
6
86
0.69
0.33
3.5
3.3
—
7.4
—
0
14
6
88
0.67
0.33
3.5
3.3
5.3
5.3
kpa
—
6
81
92
859
1.12
0.33
2.1
2.0
—
—
—
0
0
57
517
1.14
0.32
2.5
2.7
6.3
6.9
mmol/l
0.41
52
431
15
120
1.27
0.31
5.3
2.6
—
—
—
0
0
21
249
0.83
0.31
2.0
1.9
—
—
—
0
0
8
107
0.74
0.29
1.0
1.1
—
—
—
0
0
25
289
0.85
0.28
1.5
1.6
1343.0
1178.2
nmol/l
0.40
20
214
41
454
0.88
0.27
3.5
1.7
1.3
0.9
mg/l
0.44
34
359
60
648
0.90
0.26
10.0
5.5
1.1
1.1
inr
0.26
23
208
21
180
1.18
0.25
1.2
1.4
—
—
—
0
0
9
77
1.18
0.24
4.2
2.1
1.3
1.1
%
—
9
77
6
81
0.73
0.24
3.8
5.7
24.5
25.5
mmol/l
—
6
81
6
85
0.70
0.24
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
11.4
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
88.2
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.5
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
12
144
0.82
0.20
1.2
1.3
—
33.9
—
0
6
0
14
0.00
0.20
0.0
1.1
—
17.7
—
0
14
0
14
0.00
0.20
0.0
1.4
—
1.0
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
17
146
1.18
0.20
2.2
3.3
1.8
1.8
%
0.08
17
131
20
176
1.15
0.18
4.5
6.0
104.5
104.0
mmol/l
0.24
20
169
6
80
0.74
0.15
1.8
1.6
—
—
—
0
0
21
233
0.89
0.15
1.4
1.3
—
—
—
0
0
12
139
0.86
0.14
1.3
1.4
—
—
—
0
0
12
139
0.86
0.14
5.8
4.8
—
0.2
—
0
26
29
315
0.91
0.14
2.1
1.7
—
—
—
0
0
24
218
1.11
0.14
1.1
1.4
—
—
—
0
0
83
861
0.94
0.13
7.7
8.3
0.0
0.0
e9/l
0.72
72
700
16
179
0.89
0.12
1.9
1.3
—
—
—
0
0
53
557
0.94
0.12
2.0
2.0
171.8
128.8
u/l
0.32
53
531
33
353
0.92
0.12
1.8
2.3
2.5
6.7
e6/l
5.33
27
317
100
972
1.05
0.11
4.1
3.5
0.0
0.0
estimate
0.00
14
187
60
575
1.06
0.11
3.1
2.7
—
—
—
0
0
204
2058
0.91
0.10
10.9
10.8
—
—
—
0
0
44
462
0.94
0.10
2.3
2.6
—
—
—
0
0
195
1969
0.93
0.10
4.0
4.3
5.0
5.0
mmol/l
0.18
185
1862
5
48
1.04
0.09
1.6
2.6
—
—
—
0
0
22
237
0.92
0.09
1.1
1.4
—
—
—
0
0
46
480
0.95
0.09
2.7
2.9
17.2
338.4
mg/l
0.87
26
279
6
58
1.04
0.08
2.7
3.6
—
—
—
0
0
5
63
0.79
0.08
1.8
1.6
212.2
260.6
mu/l
—
5
55
6
71
0.84
0.08
1.8
1.2
—
—
—
0
0
55
532
1.04
0.07
3.6
3.7
0.0
0.0
estimate
0.00
16
189
13
118
1.11
0.07
1.5
1.2
—
—
—
0
0
10
89
1.13
0.07
4.0
4.5
—
—
—
0
0
8
93
0.86
0.07
2.5
2.4
—
—
—
0
0
8
95
0.84
0.07
8.6
6.3
26.5
25.3
mmol/l
—
8
90
198
1994
0.95
0.06
4.5
4.7
3.0
3.0
mmol/l
0.07
186
1868
51
495
1.04
0.05
5.8
7.4
—
—
—
0
0
10
110
0.90
0.05
4.6
7.7
—
—
—
0
0
189
1878
1.04
0.04
3.5
3.8
1.3
1.2
mmol/l
0.36
174
1759
43
418
1.04
0.04
1.3
1.3
34.8
10.8
u/ml
0.50
14
176
37
381
0.97
0.03
3.0
3.5
—
—
—
0
0
34
331
1.03
0.02
4.5
2.3
489.7
519.5
mosm/kgh2o
0.37
29
284
15
158
0.95
0.02
1.4
2.2
0.2
0.2
g/l
0.41
15
153
48
471
1.02
0.02
5.3
4.6
—
—
—
0
0
195
1957
0.97
0.01
3.8
4.2
1.6
1.6
mmol/l
0.74
184
1839
16
158
1.01
0.00
1.6
1.6
—
—
—
0
0
29
286
1.02
0.00
1.1
1.2
—
—
—
0
0
32
319
1.00
0.00
2.5
3.4
51.3
318.9
ng/l
0.68
18
215
57
571
1.00
0.00
2.2
3.6
7.4
7.4
ph
—
8
106
51
509
1.00
0.00
3.8
3.2
—
—
—
0
0
16
163
0.98
0.00
3.6
7.0
5.4
5.2
kpa
0.61
16
158
16
163
0.98
0.00
3.6
7.0
11.1
12.4
kpa
0.53
16
158
46
463
0.99
0.00
3.3
2.8
0.2
0.5
e6/l
1.62
36
341
170
1697
1.01
0.00
16.2
15.2
331.6
330.9
g/l
0.44
170
1688
50
502
0.99
0.00
3.3
2.8
11.3
72.7
e6/l
1.30
41
377
23
235
0.98
0.00
2.7
1.8
29.0
29.7
s
0.26
23
224
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
0.00
4.6
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
80.2
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
1.7
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
10.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
27
270
1.00
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
2.6
2.7
8.0
1878.5
u/ml
—
7
63
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
0.3
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
4.5
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
34.8
—
109.0
—
0
6
0
5
0.00
0.00
0.0
1.2
—
17.3
—
0
5
0
9
0.00
0.00
0.0
3.7
—
—
—
0
0
5
52
0.96
0.00
1.6
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_NOS – Carcinoma in situ of uteri, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).