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Carcinoma in situ of uteri, other/unspecified

DOID EFO Endpoint Browser

CD2_INSITU_CERVIX_UTERI_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D06.7&, D06.9&
  • Hospital discharge: ICD-9 — 2331
  • Cause of death: ICD-10 — D06.7&, D06.9&
  • Cause of death: ICD-9 — 2331

2 out of 7 registries used, show all original rules.

227

4. Check minimum number of events

None

227

5. Include endpoints

None

227

6. Filter based on genotype QC (FinnGen only)

227

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 227 227 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 35.79 35.79 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
212
Matched controls
2118
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
594.3
160.9
141
7
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
+∞
138.1
117
*
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
109.0
95
*
8326
FHL
Batch conization
415.6
63.0
60
*
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
194.3
32.7
33
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
10.5
30.6
64
84
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
6.9
29.8
87
193
ULA02
NOMESCO Finland
Kolposcopy
6.6
29.2
89
208
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
14.7
23.5
40
33
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.4
19.0
48
81
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
4.5
18.7
80
253
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
43.9
16.6
20
5
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
5.0
15.2
53
133
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
+∞
14.8
14
*
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
+∞
13.7
13
*
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
8.4
8
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
7.6
7.6
17
24
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
82.9
7.5
8
*
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
41.4
6.8
8
*
ZXC00
NOMESCO Finland
Use of diathermy
13.0
6.1
10
8

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_CERVIX_UTERI_NOS – Carcinoma in situ of uteri, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).