HSIL lesion of the cervix uteri

N14_CERVICAL_HSIL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06, N87.1, N87.2
  • Hospital discharge: ICD-9 6221B|6221C|2331A
  • Cause of death: ICD-10 D06, N87.1, N87.2
  • Cause of death: ICD-9 6221B|6221C|2331A

2 out of 7 registries used, show all original rules.

8654

4. Check minimum number of events

None

8654

5. Include endpoints

None

8654

6. Filter based on genotype QC (FinnGen only)

8291

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 53171 53171 -
Only index persons 51989 51989 -
Unadjusted period prevalence (%)
Whole population 1.52 1.52 -
Only index persons 1.91 1.91 -
Median age at first event (years)
Whole population - 34.59 -
Only index persons - 34.40 -

-FinnGen-

Key figures

All Female Male
Number of individuals 8291 8291 -
Unadjusted period prevalence (%) 2.94 2.94 -
Median age at first event (years) 35.28 35.28 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
8654
Matched controls
86540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZXC00
NOMESCO Finland
Use of diathermy
32.8
307.7
413
132
ULA02
NOMESCO Finland
Kolposcopy
38.5
307.7
6673
6966
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
24.5
307.7
5004
4585
A63.0
ICD-10 Finland
Anogenital (venereal) warts
4.9
307.7
1094
2507
C539, 6666, 0
ICD-O-3
186.9
307.7
1207
75
N87.0
ICD-10 Finland
Mild cervical dysplasia
8.2
307.7
1272
1773
LDA10
NOMESCO Finland
Curettage of cervix uteri
18.0
307.7
2819
2257
N87.1
ICD-10 Finland
Moderate cervical dysplasia
7895.7
307.7
4129
10
8326
FHL
Batch conization
74.5
307.7
295
41
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
13589.4
307.7
4685
7
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
85.5
307.7
337
41
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
37.2
307.7
6669
7175
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
+∞
307.7
457
*
LEB00
NOMESCO Finland
Biopsy of vagina
7.6
307.7
521
728
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
434.1
307.7
2893
100
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
129.4
307.7
5722
1286
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
13.8
307.7
5429
9388
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
6.8
307.7
713
1121
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
9.3
302.5
369
411
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
+∞
271.3
259
*
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
15.2
256.6
226
152
6221C
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI GRAVIS]
+∞
242.8
232
*
6221B
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI MODERATA]
+∞
201.8
193
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.9
179.3
4467
31156
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
308.8
177.7
180
6
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
69.9
165.5
90
13
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
10.5
154.6
171
166
R87.2
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of other drugs, medicaments and biological substances
25.2
152.8
107
43
G01AA10
ATC
clindamycin; vaginal
1.9
143.9
2270
13424
R87.1
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of hormones
30.6
138.9
91
30
8077/2-C53.1
ICD-O-3
Squamous intraepithelial neoplasia, high grade of exocervix
240.6
138.5
142
6
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
1287.9
130.6
127
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
3.7
120.4
402
1136
X86
ICPC
Abnormal cervix smear
4.6
116.9
286
643
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
8.4
116.6
153
186
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
15.6
108.5
94
61
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
106.5
102
*
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
14.0
97.1
89
64
C53.01
ICD-10 Finland
Squamous cell carcinoma of the endocervix
16.1
91.5
78
49
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
14.8
84.4
75
51
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.4
81.8
583
2500
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
80.8
1535
9395
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
17.0
79.8
66
39
N89.0
ICD-10 Finland
Mild vaginal dysplasia
7.1
73.9
111
158
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
13.9
67.2
62
45
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
7.8
66.2
91
117
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
63.9
2921
21931
P01AB01
ATC
metronidazole; oral, rectal
1.5
63.6
3853
30586
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.6
62.4
1657
11009
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
17.1
61.7
51
30
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
10.7
61.0
66
62
O34.4
ICD-10 Finland
Maternal care for other abnormalities of cervix
9.0
58.4
72
81
N87
ICD-10 Finland
Dysplasia of cervix uteri
13.2
57.9
55
42
D06BB04
ATC
podophyllotoxin; topical
1.9
51.3
728
4044
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.6
51.2
1404
9350
R87.9
ICD-10 Finland
Abnormal findings in specimens from female genital organs, unspecified abnormal finding
8.0
51.1
69
87
N07BA03
ATC
varenicline; oral
2.2
50.7
471
2251
Z3232
NOMESCO Finland
Midwife
1.6
48.4
1502
10279
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
9.4
48.0
57
61
Z3231
NOMESCO Finland
Registered nurse
1.5
45.4
1900
13829
TLC02
NOMESCO Finland
Simple extraction of IUD
1.8
43.6
677
3860
LDB00
NOMESCO Finland
Excision of lesion of cervix uteri
3.1
41.2
173
564
Z2221
NOMESCO Finland
Medical doctor
1.4
41.2
2421
18707
D06BB10
ATC
imiquimod; topical
2.0
38.4
421
2140
N90.0
ICD-10 Finland
Mild vulvar dysplasia
5.8
37.4
68
118
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
7.0
36.8
56
81
X23
ICPC
Fear sexually transm dis female
1.6
36.7
823
5190
R2110
NOMESCO Finland
Giving the first information
1.7
35.2
744
4620
8140/2-C53.1
ICD-O-3
Adenocarcinoma in situ, NOS, of exocervix
175.7
33.7
35
*
8140/2-C53.0
ICD-O-3
Adenocarcinoma in situ, NOS, of endocervix
+∞
33.3
32
*
X92
ICPC
Chlamydia infection genital female
2.5
32.1
207
846
SPAT1193
SPAT
Pap smear
1.4
32.0
1477
10860
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
31.6
6195
56466
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
3.6
31.1
103
290
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
2.3
30.1
228
1003
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
10.0
30.0
34
34
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
82.9
29.7
33
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.4
29.7
1427
10556
K05.31
ICD-10 Finland
Periodontitis pronounced
1.7
29.4
548
3287
LCH11
NOMESCO Finland
Pharmacologic abortion
1.6
28.3
659
4186
N76.0
ICD-10 Finland
Acute vaginitis
1.5
28.2
976
6778
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
2.0
28.1
332
1731
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
2.3
28.1
216
956
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.5
27.9
996
6959
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
2.0
27.2
303
1549
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
26.8
2650
21860
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
3.8
25.6
78
208
Z64.0
ICD-10 Finland
Problems related to unwanted pregnancy
1.8
24.2
404
2348
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
1.4
24.0
991
7110
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.2
23.5
208
976
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
1.8
23.5
353
1990
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
22.5
745
5115
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
4.6
22.1
52
114
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
4.0
22.1
62
156
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
1.8
21.9
334
1891
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
1.5
21.8
684
4644
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
21.8
420
2541
SPAT1308
SPAT
Sexual health counselling
1.3
21.3
1805
14502
SPAT1283
SPAT
Restricted health certificate
1.3
21.1
2161
17793
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
21.0
6434
60051
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.3
20.9
2171
17902
G01AF01
ATC
metronidazole; vaginal
1.4
20.8
823
5853
N93.0
ICD-10 Finland
Postcoital and contact bleeding
2.4
20.7
137
569
N02AX02
ATC
tramadol; systemic, rectal
1.3
20.5
2664
22559
N02BE01
ATC
paracetamol; systemic, rectal
1.3
20.4
7268
69005
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
1.3
19.9
1565
12430
Z5132
NOMESCO Finland
Nursing associate professional
3.9
19.6
56
143
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
2.6
19.5
110
424
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
19.4
228
1189
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
15.8
18.7
30
19
M03BX02
ATC
tizanidine; oral
1.2
18.6
5339
49044
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.3
18.5
2301
19336
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
6.8
18.2
28
41
X85
ICPC
Cervical disease NOS
7.1
18.2
27
38
W11
ICPC
Contraception oral
1.3
18.2
1236
9604
Z72.0
ICD-10 Finland
Tobacco use
2.0
18.1
188
939
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
2.2
18.1
144
649
J01DB01
ATC
cefalexin; oral
1.3
18.0
6924
65555
M54.5
ICD-10 Finland
Low back pain
1.2
17.8
2957
25635
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
1.7
17.1
339
2067
LCD10
NOMESCO Finland
Vaginal hysterectomy
1.8
16.7
258
1468
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
4.0
16.6
46
115
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.7
16.3
325
1985
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
16.3
4565
41559
R87.0
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of enzymes
5.2
16.2
33
64
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.4
16.0
617
4361
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
15.7
3274
28935
J01CA08
ATC
pivmecillinam; oral
1.2
15.7
4316
39164
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
1.8
15.5
225
1257
EBA00
NOMESCO Finland
Extraction of tooth
1.2
15.0
2562
22182
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
14.8
2186
18635
P17
ICPC
Tobacco abuse
2.3
14.8
111
489
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.3
14.8
1269
10157
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.3
14.8
1109
8720
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
14.6
7939
76993
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
6.7
14.0
22
33
R87.3
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of substances chiefly nonmedicinal as to source
17.5
13.8
21
12
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
13.8
3104
27539
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.4
13.7
684
5057
R87.8
ICD-10 Finland
Abnormal findings in specimens from female genital organs, other abnormal findings
3.2
13.6
53
167
K02.1
ICD-10 Finland
Caries of dentine
1.2
13.6
5151
47815
WZC00
NOMESCO Finland
Treatment plan or consultation
1.2
13.4
2602
22750
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
13.4
3160
28135
Z30.0
ICD-10 Finland
General counselling and advice on contraception
1.3
13.2
855
6577
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.5
13.0
383
2567
SDE04
NOMESCO Finland
Periodontal treatment by dental hygienist, very extensive
1.4
12.9
647
4785
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
12.9
3084
27463
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
1.5
12.9
434
2990
X15
ICPC
Vaginal symptom/complaint other
1.5
12.9
460
3206
C53.12
ICD-10 Finland
Adenocarcinoma of the exocervix
11.5
12.8
23
20
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.5
12.7
358
2377
N05CF01
ATC
zopiclone; oral
1.2
12.7
1873
15931
ZXD10
NOMESCO Finland
Scheduled procedure
1.2
12.6
2520
22063
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
12.4
3954
36038
T74.1
ICD-10 Finland
Physical abuse
1.8
12.4
176
979
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
4.7
12.3
28
60
Z87.4
ICD-10 Finland
Personal history of diseases of the genitourinary system
2.2
12.3
98
444
M03BC01
ATC
orphenadrine (citrate); systemic
1.2
12.2
1898
16220
O04.6
ICD-10 Finland
Medical abortion, complete or unspecified, complicated by delayed or excessive haemorrhage
1.9
12.1
144
758
W14
ICPC
Contraception female other
1.4
12.0
666
5007
SPAT1192
SPAT
Gynaecological examination
1.2
12.0
1362
11255
SPAT1312
SPAT
General health counselling
1.2
12.0
2381
20823
N06AX11
ATC
mirtazapine; oral
1.2
11.9
2474
21713
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.3
11.9
831
6460
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
3.4
11.9
41
120
WX290
NOMESCO Finland
Other blockage of nerve
1.2
11.8
4310
39658
SPAT1263
SPAT
Sampling
1.2
11.7
3176
28520
SFA30
NOMESCO Finland
Three-surface restoration
1.2
11.6
2992
26744
LDA96
NOMESCO Finland
Other biopsy of cervix uteri
18.9
11.6
17
9
WX408
NOMESCO Finland
General anesthesy, balanced
1.2
11.5
1596
13474
R74
ICPC
Upper respiratory infection acute
1.2
11.5
3324
29997
8077/2-C53.0
ICD-O-3
Squamous intraepithelial neoplasia, high grade of endocervix
120.2
11.4
12
*
LCH13
NOMESCO Finland
Vacuum aspiration from uterus after medically induced abortion
1.7
11.4
213
1282
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
1.6
11.3
288
1870
SDA03
NOMESCO Finland
Periodontal treatment
1.2
11.1
3359
30388
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
2.3
11.1
80
348
XLA10, ,
NOMESCO Finland
1.4
11.1
427
3019
X14
ICPC
Vaginal discharge
1.5
11.1
289
1888
N88.2
ICD-10 Finland
Stricture and stenosis of cervix uteri
4.3
11.0
28
66
J02AC01
ATC
fluconazole; systemic
1.2
10.9
4175
38455
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
10.8
5877
55615
O04.1
ICD-10 Finland
Medical abortion, incomplete, complicated by delayed or excessive haemorrhage
2.0
10.5
115
589
C53.00
ICD-10 Finland
Malignant tumor of endocervix without histology
10.0
10.5
20
20
SFA10
NOMESCO Finland
One-surface restoration
1.2
10.4
4551
42285
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.2
10.3
1559
13255
LDB10
NOMESCO Finland
Cryotherapy of cervix uteri
3.0
10.3
44
147
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
10.3
3189
28856
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
10.2
5978
56749
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
0.7
10.2
472
6373
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.2
10.1
1164
9621
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.2
10.1
1443
12206
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.2
10.0
1906
16558
M01AB05
ATC
diclofenac; systemic, rectal
1.2
10.0
5075
47610
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.2
10.0
1848
16015
F17.2
ICD-10 Finland
Mental and behavioural disorders due to use of tobacco, dependence syndrome
2.4
9.9
65
272
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
2.2
9.9
81
373
D82
ICPC
Teeth/gum disease
1.2
9.9
3186
28894
X29
ICPC
Genital sympt/compl female other
1.8
9.8
143
804
8327
FHL
Amputation portionis and conization
26.0
9.8
13
5
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
9.7
1401
11859
M79.6
ICD-10 Finland
Pain in limb
1.2
9.6
3140
28483
1390
FHL
Colposcopy
4.2
9.6
25
60
A03
ICPC
Fever
1.2
9.6
1490
12699
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
9.5
5070
47647
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.0
9.5
98
493
D11
ICPC
Diarrhoea
1.2
9.5
1032
8477
LDA00
NOMESCO Finland
Dilatation of cervix uteri
2.1
9.4
83
393
AA1AD
NOMESCO Finland
CT of head and brain
1.2
9.4
1110
9194
N93.9
ICD-10 Finland
Abnormal uterine and vaginal bleeding, unspecified
1.5
9.4
256
1690
8010/2-C53.9
ICD-O-3
Carcinoma in situ, NOS, of cervix uteri
100.2
9.4
10
*
SFA20
NOMESCO Finland
Two-surface restoration
1.2
9.4
5009
47048
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
9.4
9
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.1
9.3
84
402
N97.2
ICD-10 Finland
Female infertility of uterine origin
3.9
9.3
26
66
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.3
9.2
581
4454
7950A
ICD-9 Finland
Nonspecific abnormal histological and immunological findings, Nonspecific abnormal Papanicolaou smear of cervix
7.3
9.2
21
29
N72
ICD-10 Finland
Inflammatory disease of cervix uteri
2.2
9.2
77
358
J01AA02
ATC
doxycycline; systemic
1.2
9.1
5946
56611
Z30.8
ICD-10 Finland
Other contraceptive management
1.5
9.0
316
2197
J05AB01
ATC
aciclovir; systemic
1.2
8.9
1652
14303
C53.0
ICD-10 Finland
Malignant neoplasm: Endocervix
12.5
8.8
15
12
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.3
8.8
864
7015
Z30.2
ICD-10 Finland
Sterilization
1.2
8.8
994
8199
WF002
NOMESCO Finland
Radical radiotherapy
1.7
8.7
138
796
M77.1
ICD-10 Finland
Lateral epicondylitis
1.3
8.6
682
5392
Z71.8
ICD-10 Finland
Other specified counselling
1.2
8.6
2543
22855
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
8.6
177
1097
8070/3-C53.1
ICD-O-3
Squamous cell carcinoma, NOS, of exocervix
11.6
8.6
15
13
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.2
8.5
1437
12329
X91
ICPC
Condylomata acuminata female
2.8
8.5
42
153
LDC10
NOMESCO Finland
Partial excision of cervix uteri
9.0
8.5
17
19
L03
ICPC
Low back symptom/complaint
1.2
8.5
2081
18427
M01AH05
ATC
etoricoxib; oral
1.1
8.5
4762
44726
Z09.9
ICD-10 Finland
Follow-up examination after unspecified treatment for other conditions
1.9
8.5
100
527
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
8.5
2199
19558
6440A
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]
1.7
8.5
146
864
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
1.2
8.4
1095
9161
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
8.4
2216
19737
LCD30
NOMESCO Finland
Radical hysterectomy
4.5
8.3
20
45
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
1.5
8.3
277
1908
T810, N872,
ICD-10 Finland
+∞
8.3
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.2
8.3
2208
19673
W12
ICPC
Contraception intrauterine
1.2
8.1
1403
12057
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
3.9
8.1
23
59
Z01.2
ICD-10 Finland
Dental examination
1.1
8.1
3812
35348
SDA05
NOMESCO Finland
Very demanding periodontal treatment
1.3
8.1
456
3441
LCH00
NOMESCO Finland
Vacuum aspiration of products of conception from uterus
1.4
8.0
337
2425
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.3
8.0
790
6415
OAA64, ,
SPAT
1.4
8.0
415
3091
N06AX16
ATC
venlafaxine; oral
1.2
8.0
1216
10332
J01DA01
ATC
[U] cefalexin
1.1
7.9
4844
45656
ZXE00
NOMESCO Finland
One hour or less
1.1
7.9
2903
26457
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
1.6
7.9
199
1294
N05BA04
ATC
oxazepam; oral
1.2
7.9
1885
16645
M01AE02
ATC
naproxen; oral, rectal
1.1
7.8
4621
43445
WX002
NOMESCO Finland
Sedation and analgesia
1.2
7.8
931
7723
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
2.1
7.7
65
304
C539, 8085, 3
ICD-O-3
15.0
7.7
12
8
4044, ,
NOMESCO Finland
6.3
7.7
19
30
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
1.6
7.7
172
1089
J01FA10
ATC
azithromycin; systemic
1.1
7.7
5034
47615
J01FF01
ATC
clindamycin; systemic
1.2
7.7
1757
15464
M54
ICD-10 Finland
Dorsalgia
1.2
7.6
991
8288
ULC02
NOMESCO Finland
Hysteroscopy
1.3
7.6
419
3150
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.3
7.6
448
3402
ZXC96
NOMESCO Finland
Robot assisted procedure
2.1
7.6
69
332
XQ900
NOMESCO Finland
Photography of physically assaulted person
18.4
7.6
11
6
LDC96
NOMESCO Finland
Other excision of cervix uteri
18.4
7.6
11
6
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.2
7.6
865
7137
SPAT1301
SPAT
No procedures
1.2
7.6
1929
17114
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
0.8
7.6
1046
12352
N07BB01
ATC
disulfiram; oral
1.5
7.6
191
1244
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
1.5
7.6
198
1300
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.1
7.5
3120
28643
H02AB06
ATC
prednisolone; systemic
1.1
7.5
3189
29323
SXA20
NOMESCO Finland
Local application of medicine to mouth
1.3
7.5
506
3921
LWE00
NOMESCO Finland
Reoperation for deep haemorrhage in gynaecological surgery
2.8
7.5
36
130
Z30
ICD-10 Finland
Contraceptive management
1.4
7.4
295
2102
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.2
7.4
1815
16047
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.5
7.3
222
1504
N06AB04
ATC
citalopram; systemic
1.2
7.3
1485
12937
R21
ICPC
Throat symptom/complaint
1.2
7.3
2126
19043
C539, 8483, 2
ICD-O-3
+∞
7.3
7
*
M54.4
ICD-10 Finland
Lumbago with sciatica
1.2
7.3
1278
10995
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.2
7.3
1410
12234
X84
ICPC
Vaginitis/vulvitis NOS
1.8
7.3
95
520
SPAT1254
SPAT
Administration of medicine
1.3
7.1
663
5354
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.2
7.1
1566
13737
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.2
7.0
1049
8890
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
1.4
7.0
270
1915
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.1
7.0
4159
39002
H00.00
ICD-10 Finland
Hordeolum
1.4
6.9
325
2385
L04AX01
ATC
azathioprine; systemic
1.4
6.9
264
1872
F51.0
ICD-10 Finland
Nonorganic insomnia
1.2
6.8
1477
12925
N93.8
ICD-10 Finland
Other specified abnormal uterine and vaginal bleeding
1.6
6.8
169
1097
TLE30
NOMESCO Finland
Tamponation of vagina
4.1
6.8
18
44
WZA90
NOMESCO Finland
Other medical or dental certificate
1.2
6.7
1621
14306
Z72.1
ICD-10 Finland
Alcohol use
2.1
6.7
57
268
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.2
6.7
1952
17469
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.3
6.7
551
4380
N05AH04
ATC
quetiapine; oral
1.2
6.6
1341
11674
SPAT1249
SPAT
Treatment-related counselling outside office
1.1
6.6
3046
28093
P01
ICPC
Feeling anxious/nervous/tense
1.2
6.6
1274
11049
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.2
6.6
1044
8900
8140/3-C53.0
ICD-O-3
Adenocarcinoma, NOS, of endocervix
10.0
6.5
12
12
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
1.3
6.5
533
4235
WX402
NOMESCO Finland
General anaesthesia
1.2
6.5
1440
12623
TKC20
NOMESCO Finland
Catheterisation of bladder
1.5
6.5
211
1453
P01BA02
ATC
hydroxychloroquine; oral
1.3
6.4
521
4135
TAC99
NOMESCO Finland
Other blockade for chronic pain
2.5
6.4
39
159
SGC10
NOMESCO Finland
Pulp capping
1.2
6.4
749
6202
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
1.6
6.3
155
1006
X59
ICD-10 Finland
Exposure to unspecified factor
1.2
6.3
1087
9335
D01
ICPC
Abdominal pain/cramps general
1.2
6.3
880
7415
8070/2-C53.1
ICD-O-3
Squamous cell carcinoma in situ, NOS, of exocervix
+∞
6.2
6
*
62191
ICD-8 Finland
Other diseases of cervix, Dysplasia portionis uteri
3.1
6.2
25
82
LDD00
NOMESCO Finland
Suture of cervix uteri
5.3
6.1
17
32
8112
FHL
Scraping the cervix
5.7
6.1
16
28
B02AA02
ATC
tranexamic acid; systemic
1.2
6.1
1442
12698
P19
ICPC
Drug abuse
2.0
6.1
59
292
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.3
6.1
594
4818
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
2.7
6.1
30
110
J01CA04
ATC
amoxicillin; systemic
1.2
6.1
6987
67893
M03BC51
ATC
orphenadrine, combinations; systemic
1.1
6.1
2047
18486
SPAT1153
SPAT
Removal of sutures
1.2
6.0
1604
14249
LCD11
NOMESCO Finland
Laparoscopically assisted vaginal hysterectomy
1.9
6.0
70
370
N05CF02
ATC
zolpidem; oral
1.2
6.0
1226
10675
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
2.5
6.0
35
140

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1627
1818
10.79
307.65
2.3
1.5
—
—
—
0
0
4911
31385
2.31
305.28
2.6
1.9
—
—
—
0
0
944
4905
2.04
82.54
1.4
1.3
—
—
—
0
0
82
154
5.37
41.48
1.6
2.1
7.02
4.36
ug/l
0.19
54
87
3049
26522
1.23
17.77
2.1
2.0
—
—
—
0
0
1212
9450
1.33
17.32
1.3
1.2
—
—
—
0
0
5521
51332
1.21
15.23
4.1
3.9
—
—
—
0
0
5337
49531
1.20
14.73
4.0
3.9
1788.75
1872.93
e6/l
0.03
55
515
5703
53403
1.20
13.70
3.9
3.7
9.49
9.67
mm/h
0.60
5373
50424
4094
37364
1.18
12.80
3.4
3.2
0.00
0.00
estimate
2.96
830
7389
4064
37109
1.18
12.52
4.5
4.4
0.00
0.00
estimate
0.05
850
7507
7690
74534
1.28
11.75
10.9
10.1
18.69
18.20
mg/l
0.66
5939
57140
4040
37026
1.17
11.50
3.3
3.2
0.00
0.00
estimate
0.36
874
7654
7340
70792
1.24
11.45
10.2
9.6
3.90
3.89
mmol/l
0.74
7112
68764
1088
8814
1.27
11.34
2.2
2.2
4249.26
6218.15
u/l
1.51
430
3663
2572
22787
1.18
10.94
2.1
1.9
—
—
—
0
0
5376
50496
1.17
10.93
6.9
6.6
70.94
71.92
u/l
1.24
5069
47835
7312
70589
1.23
10.72
10.1
9.5
139.48
139.55
mmol/l
1.66
7100
68751
476
3458
1.40
10.61
4.0
2.7
—
—
—
0
0
3903
35973
1.15
9.64
5.9
5.6
0.04
0.04
e9/l
0.26
3471
31934
2567
22963
1.17
9.39
3.3
3.2
56.16
72.43
e6/l
1.03
1642
14759
3886
35905
1.15
9.05
5.9
5.6
0.53
0.52
e9/l
0.70
3470
31968
3672
33801
1.15
9.01
6.5
6.0
—
—
—
0
0
3656
33710
1.15
8.63
6.1
5.6
2.71
2.77
%
0.93
3447
31795
7920
77422
1.27
8.61
9.0
8.4
23.57
23.84
u/l
0.41
7700
75365
585
4535
1.31
8.57
2.8
1.9
—
—
—
0
0
3672
33890
1.15
8.50
6.4
5.9
7.81
7.83
%
0.19
3474
32048
1849
16243
1.18
8.32
2.9
2.7
0.30
0.29
e6/l
0.08
1354
11896
628
4948
1.29
8.15
2.7
1.9
—
—
—
0
0
5582
53070
1.15
8.14
2.9
2.7
34.18
32.99
u/l
0.63
5337
50890
304
2146
1.43
8.05
3.4
2.5
—
—
—
0
0
1123
9465
1.21
8.01
2.4
2.3
0.98
1.15
e6/l
0.74
597
5059
631
4989
1.29
7.97
2.7
1.9
—
—
—
0
0
3517
32463
1.14
7.95
6.2
5.7
0.68
0.69
%
0.32
3294
30431
1447
12496
1.19
7.94
1.7
1.6
—
—
—
0
0
628
4973
1.28
7.84
2.3
1.9
—
—
—
0
0
1892
16737
1.17
7.73
2.1
1.9
—
—
—
0
0
3892
36205
1.14
7.73
2.5
2.4
—
—
—
0
0
4011
37390
1.14
7.70
6.0
5.6
1.98
1.97
e9/l
0.16
3657
34083
4005
37338
1.14
7.66
6.2
5.8
0.18
0.18
e9/l
0.09
3633
33730
3756
34918
1.13
7.43
5.8
5.5
56.49
56.47
%
0.04
3558
33096
4368
41028
1.13
7.25
8.3
8.3
3.99
3.94
e9/l
0.70
3874
36340
3470
32158
1.13
7.11
5.3
5.2
9.13
9.49
umol/l
1.84
3252
30323
491
3818
1.30
7.07
3.0
2.0
—
—
—
0
0
3795
35377
1.13
7.05
6.1
5.6
29.72
29.79
%
0.18
3600
33555
1866
16602
1.16
6.98
3.3
3.2
—
—
—
0
0
613
4911
1.27
6.98
2.6
1.8
—
—
—
0
0
2281
20591
1.15
6.96
2.5
2.4
—
—
—
0
0
2170
19528
1.15
6.92
3.7
3.5
0.00
0.00
estimate
0.07
849
7422
3257
30108
1.13
6.88
3.0
3.0
6.02
5.96
ph
0.62
336
3434
1843
16409
1.16
6.81
2.8
2.6
—
—
—
0
0
3430
31827
1.13
6.79
8.3
7.9
0.00
0.00
e9/l
3.45
2841
26159
1043
8874
1.20
6.71
2.6
2.5
4.94
5.03
e6/l
0.07
518
4490
1997
17913
1.15
6.63
2.9
2.7
40.39
70.74
e6/l
1.29
1473
13277
8456
83684
1.46
6.38
16.3
15.2
39.73
39.82
%
0.47
8157
80132
1710
15212
1.15
6.35
1.3
1.3
11.77
8.85
u/ml
0.99
673
6581
750
6215
1.23
6.32
2.2
2.7
47.55
37.21
u/ml
0.24
726
6005
3020
27904
1.13
6.27
5.8
5.3
1.22
1.22
mmol/l
1.09
2578
23859
74
403
1.84
5.83
1.2
1.1
—
—
—
0
0
2697
24848
1.12
5.76
5.1
4.6
1.22
1.22
mmol/l
0.73
2474
22978
8038
79087
1.23
5.67
10.1
9.5
—
—
—
0
0
2704
24941
1.12
5.64
4.4
4.2
36.79
36.80
g/l
0.03
2545
23343
1744
15680
1.14
5.48
3.6
3.3
98.18
98.75
%
0.49
1686
15177
8460
83813
1.42
5.47
16.3
15.2
269.62
269.37
e9/l
0.13
8320
82396
7312
71409
1.15
5.42
5.0
5.1
1.66
2.00
mu/l
3.58
6916
68129
8465
83878
1.42
5.39
16.2
15.1
30.23
29.99
pg
33.44
8396
83210
8465
83881
1.42
5.36
16.2
15.2
90.69
90.11
fl
30.49
8394
83216
2411
22146
1.12
5.35
6.8
7.0
1.08
1.07
inr
0.13
797
7313
8465
83891
1.41
5.25
16.3
15.2
4.42
4.46
e12/l
13.91
8320
82382
8465
83901
1.41
5.14
16.3
15.2
6.79
6.69
e9/l
4.50
8318
82336
6562
63718
1.12
5.01
4.4
4.4
14.28
14.27
pmol/l
0.15
6161
60203
8466
83926
1.40
5.00
16.4
15.3
133.01
133.00
g/l
0.04
8397
83250
2057
18813
1.12
4.84
1.7
1.7
—
—
—
0
0
80
476
1.69
4.74
4.7
2.2
—
—
—
0
0
1741
15845
1.12
4.42
1.3
1.3
43.00
28.17
iu/ml
0.39
564
5125
2181
20110
1.11
4.39
2.4
2.4
53.30
58.28
u/l
3.17
2017
18720
406
3292
1.24
4.28
1.6
1.7
—
—
—
0
0
1288
11541
1.14
4.20
2.8
2.5
521.38
519.16
mosm/kgh2o
0.12
1095
9831
604
5124
1.19
4.06
1.3
1.2
—
—
—
0
0
79
490
1.62
4.05
1.6
1.5
1.49
1.25
promille
0.81
58
368
1046
9278
1.14
3.98
1.3
1.3
24.07
25.60
iu/l
0.87
915
8142
4536
43471
1.09
3.95
2.7
2.7
—
—
—
0
0
542
4576
1.20
3.86
1.4
1.3
—
—
—
0
0
2443
22784
1.10
3.86
1.7
1.8
—
—
—
0
0
1381
12495
1.13
3.85
2.4
2.3
10.16
8.59
e6/l
0.96
1216
11053
1728
15847
1.11
3.79
1.9
2.0
175.44
137.75
u/l
0.68
1645
15055
6873
67209
1.11
3.73
3.4
3.4
5.54
5.57
mmol/l
1.41
6450
63417
2490
23275
1.10
3.73
1.7
1.8
99.36
99.63
pmol/l
0.10
1375
12504
1882
17351
1.11
3.73
6.1
6.3
—
—
—
0
0
1356
12286
1.12
3.68
1.4
1.4
542.94
568.28
titre
0.18
279
2499
236
1836
1.29
3.57
2.3
1.9
1.43
1.35
g/l
0.52
206
1598
2061
19179
1.10
3.35
2.5
2.5
29.40
67.43
ng/l
0.46
815
7856
2207
20604
1.10
3.34
2.9
3.0
2.35
2.34
mmol/l
0.17
2010
18740
14
48
2.92
3.29
9.1
11.0
4.61
4.96
mmol/l
0.26
14
48
7
11
6.37
3.18
1.0
1.0
—
—
—
0
0
1701
15738
1.10
3.10
3.5
3.4
1.02
1.02
kg/l
0.34
247
2422
1295
11830
1.11
3.04
2.5
2.4
107.25
97.21
ug/g
0.52
994
9300
897
8025
1.13
3.02
1.6
1.6
—
—
—
0
0
588
5118
1.16
2.96
3.0
3.3
—
—
—
0
0
88
604
1.46
2.96
1.7
1.4
55.76
67.10
mmol/l
1.72
75
473
764
6780
1.14
2.93
3.7
3.3
—
—
—
0
0
2568
24264
1.08
2.88
3.3
3.0
29.41
29.52
u/l
0.03
2439
23254
825
7375
1.13
2.83
3.0
2.4
5.66
6.05
umol/l
0.35
674
6156
3779
36256
1.08
2.82
4.0
3.8
6.21
6.27
mmol/l
1.02
3394
32525
158
1209
1.31
2.79
1.3
1.5
—
—
—
0
0
6817
66884
1.09
2.77
13.0
12.1
14.87
14.75
%
0.07
6714
65831
1017
9216
1.12
2.77
2.7
2.8
244.80
279.62
ng/l
0.22
507
4648
1085
9871
1.11
2.75
2.4
2.4
2.42
2.42
mmol/l
0.03
942
8594
1792
16713
1.09
2.73
4.0
3.5
7.40
7.40
ph
0.30
343
3217
10
29
3.45
2.68
1.2
1.3
—
—
—
0
0
510
4437
1.16
2.62
7.1
6.5
13.28
13.86
kpa
1.53
482
4237
814
7308
1.13
2.61
1.4
1.3
—
—
—
0
0
510
4438
1.16
2.61
7.1
6.5
5.06
5.02
kpa
0.53
484
4244
241
1961
1.24
2.60
10.0
8.4
24.22
24.11
mmol/l
0.18
232
1908
99
715
1.39
2.57
3.1
2.5
1.28
1.46
%
0.25
88
654
237
1929
1.24
2.56
1.5
1.6
—
—
—
0
0
1345
12431
1.10
2.50
3.9
3.6
—
—
—
0
0
891
8069
1.12
2.47
1.5
1.5
—
—
—
0
0
905
8207
1.11
2.45
1.8
1.8
—
—
—
0
0
36
210
1.72
2.45
2.8
2.7
—
—
—
0
0
758
6805
1.12
2.45
3.0
3.3
32.94
32.73
%
0.22
602
5214
622
5535
1.13
2.33
2.4
2.3
4.60
4.41
e9/l
0.21
532
4850
48
307
1.57
2.31
2.3
2.3
122.82
171.81
umol/l
0.78
33
152
2240
21219
1.08
2.29
1.3
1.3
1.64
1.44
u/ml
0.31
663
6341
48
308
1.56
2.29
1.9
1.9
—
—
—
0
0
421
3654
1.16
2.27
7.9
7.2
119.90
121.03
g/l
0.61
410
3545
438
3814
1.16
2.27
7.4
7.0
96.22
96.36
%
0.16
420
3653
118
896
1.32
2.27
1.0
1.1
—
—
—
0
0
507
4462
1.14
2.26
7.0
6.5
0.82
0.78
mmol/l
0.09
385
3404
63
431
1.47
2.24
3.4
2.5
54.95
55.06
%
0.01
56
369
393
3398
1.16
2.24
9.5
7.5
—
—
—
0
0
350
3000
1.17
2.23
1.4
1.5
82.37
97.19
pmol/l
0.41
345
2929
174
1397
1.25
2.18
1.9
2.0
2.87
2.84
g/l
0.16
159
1295
330
2821
1.18
2.18
1.4
1.4
20.77
24.07
u/l
1.21
248
2348
11
42
2.62
2.14
1.0
1.5
—
—
—
0
0
2764
26429
1.07
2.13
1.7
1.8
—
—
—
0
0
2293
21797
1.07
2.10
3.0
2.8
—
—
—
0
0
229
1901
1.21
2.10
2.6
2.1
10.42
10.11
mg/l
0.26
220
1796
38
236
1.61
2.09
24.4
25.5
114.28
112.18
ug/l
0.08
32
194
14
62
2.26
2.07
13.1
4.9
—
—
—
0
0
250
2097
1.20
2.07
8.6
8.3
—
—
—
0
0
143
1131
1.27
2.05
1.8
1.9
38.70
39.07
g/l
0.33
128
1028
49
326
1.51
2.02
1.1
1.1
1.96
2.56
u/ml
0.15
30
180
925
8491
1.10
2.01
3.3
3.0
0.82
0.83
mmol/l
1.43
870
8035
75
542
1.39
2.01
2.2
2.3
—
—
—
0
0
178
1449
1.23
2.00
1.9
2.0
3.64
3.54
g/l
0.45
163
1348
178
1450
1.23
1.99
1.9
2.0
7.25
7.21
g/l
0.14
163
1347
1323
12352
1.08
1.97
1.4
1.4
21.21
21.10
nmol/l
0.11
1163
11013
176
1435
1.23
1.95
2.9
3.3
161.89
259.35
u/ml
0.34
151
1232
546
4884
1.13
1.93
4.2
3.8
0.73
0.65
%
0.12
160
1252
38
583
0.65
1.92
1.3
1.5
—
—
—
0
0
480
4261
1.13
1.92
1.4
1.4
—
—
—
0
0
276
2354
1.18
1.91
9.3
8.1
93.77
94.38
%
0.68
276
2343
6148
60355
1.06
1.91
3.9
4.1
36.79
37.32
mmol/mol
6.30
5791
57324
265
2253
1.18
1.91
2.5
2.5
3.67
3.60
g/l
0.34
242
2121
1866
17672
1.07
1.90
1.4
1.4
2.13
2.10
g/l
0.43
1148
11403
0
52
0.00
1.88
0.0
1.6
—
31.05
—
0
39
545
4886
1.12
1.87
2.4
2.2
0.23
0.23
g/l
2.24
506
4635
171
1398
1.23
1.87
3.6
2.9
1.38
1.30
mg/l
0.57
163
1320
314
2713
1.16
1.86
2.5
2.0
0.22
0.23
g/l
0.47
294
2593
323
2797
1.16
1.86
2.5
2.0
1.14
1.17
g/l
0.85
305
2681
367
3210
1.15
1.84
1.3
1.2
—
—
—
0
0
280
2401
1.17
1.83
3.5
4.6
—
—
—
0
0
116
916
1.27
1.74
2.6
3.2
34.50
40.82
mg/l
0.44
95
739
1515
14295
1.07
1.71
2.7
2.7
—
—
—
0
0
52
364
1.43
1.71
3.2
3.0
9.47
7.84
mg/l
0.54
41
277
504
4527
1.12
1.70
3.4
3.2
—
—
—
0
0
588
5328
1.11
1.69
2.6
2.5
10.55
10.45
g/l
0.25
539
4893
277
2391
1.16
1.69
1.4
1.6
8.60
9.98
u/ml
—
5
63
27
164
1.65
1.67
4.5
5.0
—
—
—
0
0
36
235
1.53
1.67
1.2
1.4
—
—
—
0
0
921
8535
1.09
1.66
2.4
2.2
2.44
2.49
g/l
1.98
832
7930
8
31
2.58
1.65
1.5
1.3
387.60
524.95
nmol/l
—
8
31
268
3097
0.86
1.65
1.1
1.2
—
—
—
0
0
40
268
1.49
1.65
2.1
2.0
—
—
—
0
0
944
8764
1.09
1.64
1.7
1.7
1158.90
1193.82
nmol/l
0.59
753
6947
115
916
1.26
1.63
2.7
3.2
27.26
38.14
mg/l
0.81
94
739
106
837
1.27
1.61
3.5
3.0
31.61
33.16
umol/l
0.43
101
782
582
5288
1.11
1.60
4.4
4.0
0.72
0.87
%
0.51
174
1403
316
2769
1.15
1.59
1.9
2.1
6.97
5.35
ug/l
0.28
278
2414
31
199
1.56
1.56
3.6
4.6
5485.13
3738.30
mg/l
0.12
24
142
552
5012
1.11
1.55
1.4
1.3
203.29
236.35
miu/ml
1.72
273
2585
160
1329
1.21
1.55
1.9
2.0
10.46
10.12
g/l
0.45
144
1220
256
2216
1.16
1.54
1.3
1.3
—
—
—
0
0
797
7373
1.09
1.52
1.1
1.2
—
—
—
0
0
559
5086
1.11
1.52
4.5
4.1
0.07
0.13
%
1.41
152
1203
0
45
0.00
1.49
0.0
1.7
—
12.92
—
0
39
507
4594
1.11
1.49
3.2
3.6
6.09
21.94
ug/l
1.17
373
3276
540
4911
1.11
1.48
4.4
4.1
0.13
0.38
%
0.75
135
1038
287
2513
1.15
1.48
1.9
2.0
—
—
—
0
0
824
7643
1.09
1.48
2.0
2.1
29.26
29.07
s
0.30
796
7388
10
45
2.22
1.46
1.0
1.6
—
—
—
0
0
65
488
1.33
1.46
2.8
2.8
41596.49
39527.75
ug/l
0.37
65
488
7178
70989
1.07
1.45
3.6
3.7
2.90
2.92
mmol/l
1.03
6826
67640
30
197
1.52
1.39
1.9
1.5
—
—
—
0
0
47
338
1.39
1.39
2.3
2.8
39.88
47.30
%
1.31
20
211
586
5373
1.10
1.38
1.3
1.3
27.29
39.51
au/ml
1.50
21
261
68
519
1.31
1.38
2.9
2.7
—
—
—
0
0
632
5819
1.09
1.36
2.3
2.3
17.78
22.74
au/ml
1.23
58
595
5
17
2.94
1.36
1.0
1.2
159.96
219.17
nmol/l
—
5
17
206
1777
1.16
1.33
2.2
2.2
—
—
—
0
0
451
4091
1.11
1.33
1.6
1.8
1.31
1.34
g/l
0.20
416
3802
149
1253
1.19
1.31
3.3
2.7
7.42
7.42
ph
0.05
133
1162
180
1539
1.17
1.31
1.3
1.3
—
—
—
0
0
108
881
1.23
1.30
2.7
3.2
1.47
1.33
ratio
—
6
103
1783
17080
1.06
1.26
2.1
2.1
2.67
2.68
mg/l
0.06
1531
14792
496
4539
1.10
1.24
2.7
2.6
—
—
—
0
0
4348
42557
1.04
1.22
2.9
3.0
71.63
66.37
ug/l
1.40
4103
40596
53
401
1.32
1.18
3.0
2.6
0.12
0.28
e9/l
1.36
53
396
77
613
1.26
1.17
1.8
1.9
18.29
26.11
mg/l
1.02
21
170
349
3150
1.11
1.16
2.4
2.5
71.05
71.80
e9/l
0.11
264
2288
823
7717
1.07
1.16
1.4
1.4
—
—
—
0
0
0
36
0.00
1.14
0.0
1.5
—
0.97
—
0
30
3182
30977
1.04
1.13
2.3
2.3
75.25
2891.06
nmol/l
0.50
2952
29116
649
6039
1.08
1.13
2.5
2.3
33.64
35.89
u/l
0.37
546
5152
5
113
0.44
1.12
1.4
1.1
—
—
—
0
0
119
1413
0.84
1.12
1.1
1.1
115.49
119.28
%
0.64
109
1299
311
2800
1.11
1.10
2.2
2.4
135.12
108.30
ng/l
0.56
274
2492
106
882
1.20
1.09
1.5
1.6
—
—
—
0
0
300
2699
1.12
1.08
3.0
2.8
—
—
—
0
0
127
1077
1.18
1.07
2.4
2.0
131.52
130.72
g/l
0.15
94
806
397
3631
1.10
1.05
4.5
3.6
5.85
5.82
kpa
0.20
389
3512
33
237
1.39
1.04
1.2
1.3
—
—
—
0
0
106
888
1.20
1.03
5.3
5.6
376.09
375.32
umol/l
0.02
99
759
87
715
1.22
1.03
1.1
1.1
—
—
—
0
0
809
7620
1.07
1.03
2.6
2.3
24.62
23.91
%
0.71
695
6612
120
1019
1.18
1.01
2.1
1.8
36.82
34.81
iu/ml
0.06
11
59
401
3678
1.09
1.01
8.0
6.1
1.24
1.24
mmol/l
0.02
390
3594
424
3899
1.09
1.01
1.3
1.3
1.38
1.05
u/ml
0.17
31
320
725
7713
0.93
1.00
1.6
1.7
—
—
—
0
0
7104
70409
1.05
1.00
3.4
3.4
4.84
4.85
mmol/l
0.44
6797
67431
393
3602
1.10
1.00
4.5
3.6
1.85
1.77
mmol/l
0.18
335
3035
7070
70065
1.05
1.00
3.3
3.4
1.55
1.55
mmol/l
0.24
6758
67014
204
1806
1.13
0.99
1.2
1.2
—
—
—
0
0
1024
9732
1.06
0.98
2.5
2.4
650.78
569.31
ng/l
0.53
838
7833
110
930
1.19
0.98
4.6
6.4
11.08
11.10
mmol/l
0.02
99
832
268
2413
1.11
0.98
1.4
1.3
6.79
9.02
u/ml
0.52
54
393
72
584
1.23
0.98
1.1
1.2
—
—
—
0
0
33
447
0.74
0.97
1.1
1.3
—
—
—
0
0
110
931
1.18
0.97
4.6
6.4
106.31
105.62
mmol/l
1.15
99
833
103
867
1.19
0.97
5.3
3.6
—
—
—
0
0
173
1518
1.14
0.96
4.0
4.9
1.17
1.22
mmol/l
0.40
156
1334
159
1387
1.15
0.96
2.5
2.6
—
—
—
0
0
24
165
1.46
0.96
2.0
2.4
—
—
—
0
0
12
69
1.74
0.96
1.0
1.1
1.51
1.53
umol/24h
0.02
12
69
294
2664
1.11
0.96
1.3
1.3
35.37
34.64
u/ml
0.03
23
190
264
2380
1.11
0.95
1.4
1.3
14.30
6.84
u/ml
0.70
41
243
0
32
0.00
0.95
0.0
1.0
—
0.05
—
0
22
1774
17118
1.05
0.95
1.7
1.7
0.98
0.85
mg/l
0.83
1312
12720
1006
9570
1.06
0.94
2.4
2.2
15.05
14.50
umol/l
1.43
930
8982
659
6187
1.07
0.94
6.5
4.9
1.04
1.04
mmol/l
0.21
624
5816
81
669
1.21
0.93
1.2
1.2
—
—
—
0
0
1215
12695
0.95
0.93
2.0
2.1
—
—
—
0
0
188
1665
1.13
0.92
1.3
1.4
334.04
313.63
ug/g
0.55
102
847
110
937
1.18
0.91
2.8
2.1
17.00
16.83
%
0.16
57
449
405
3737
1.09
0.91
4.4
3.5
7.35
7.38
ph
—
6
20
1612
15537
1.05
0.91
3.5
3.1
7.44
7.52
mmol/l
0.27
1427
13714
108
1264
0.85
0.90
1.4
1.5
0.55
0.62
g/l
0.43
76
960
8
42
1.91
0.88
1.4
1.6
322.25
306.21
umol/24h
—
8
42
6797
67357
1.04
0.87
3.1
3.1
1.19
1.18
mmol/l
0.42
6456
64180
133
1527
0.87
0.87
1.3
1.2
2.87
4.12
u/ml
1.23
62
615
16
103
1.55
0.87
1.3
1.2
—
—
—
0
0
31
415
0.75
0.87
1.1
1.1
—
—
—
0
0
208
1862
1.12
0.87
1.4
1.3
2.55
2.98
u/ml
0.11
21
135
6
30
2.00
0.87
1.2
1.1
—
—
—
0
0
59
476
1.24
0.86
4.0
2.8
—
—
—
0
0
288
2625
1.10
0.86
2.3
2.1
44.63
4.38
iu/l
0.51
136
1116
34
255
1.33
0.86
1.4
1.7
191.26
145.31
au/ml
—
5
32
29
212
1.37
0.86
1.0
1.1
—
—
—
0
0
44
343
1.28
0.85
2.3
2.4
10.56
10.89
%
0.21
44
343
102
870
1.17
0.85
1.1
1.1
1.47
1.47
g/l
0.03
95
796
12
72
1.67
0.85
1.7
1.8
—
—
—
0
0
317
2906
1.09
0.84
3.8
3.0
4.63
4.65
kpa
0.08
310
2800
258
2839
0.91
0.84
1.2
1.2
—
—
—
0
0
8
45
1.78
0.84
1.1
1.1
—
—
—
0
0
78
931
0.84
0.84
2.6
2.5
52.96
85.93
ug/min
0.65
50
597
194
1735
1.12
0.83
1.3
1.3
—
—
—
0
0
45
568
0.79
0.83
17.6
16.8
1492.51
4436.45
nmol/l
0.79
45
547
8
139
0.58
0.83
1.4
1.2
—
—
—
0
0
500
4676
1.07
0.82
2.3
2.5
1.72
1.70
%
0.14
448
4185
146
1655
0.88
0.81
1.1
1.1
11.41
10.56
au/ml
0.06
12
126
12
73
1.64
0.81
1.0
1.1
0.08
0.63
u/ml
—
5
29
23
318
0.72
0.80
1.3
1.2
—
—
—
0
0
35
267
1.31
0.80
2.3
1.9
56.80
21.96
ug/l
0.46
35
262
44
554
0.79
0.80
1.1
1.3
1.68
1.61
g/l
1.22
44
554
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
16
106
1.51
0.78
1.2
1.3
—
—
—
0
0
181
1620
1.12
0.78
1.3
1.3
141.75
108.86
u/ml
0.61
39
385
29
384
0.75
0.78
1.3
1.5
124.59
129.58
nmol/l
0.27
29
384
27
199
1.36
0.78
1.1
1.1
—
—
—
0
0
27
199
1.36
0.78
1.1
1.1
—
—
—
0
0
27
199
1.36
0.78
1.1
1.1
—
—
—
0
0
28
208
1.35
0.77
2.8
2.6
117.33
98.60
ng/l
0.11
13
106
372
3454
1.08
0.76
9.9
6.9
7.80
7.08
mmol/l
1.42
353
3331
352
3265
1.08
0.74
2.2
2.3
67.05
67.31
g/l
0.28
323
3018
6
108
0.56
0.72
1.0
1.4
—
—
—
0
0
14
92
1.52
0.72
1.0
1.0
0.07
0.22
u/ml
—
8
57
20
142
1.41
0.72
3.4
2.1
—
—
—
0
0
165
1479
1.12
0.71
1.0
1.0
0.22
0.25
u/ml
0.07
31
380
44
545
0.81
0.71
14.0
12.1
850.48
843.25
nmol/l
0.04
44
524
1134
11777
0.96
0.71
1.3
1.3
—
—
—
0
0
121
1065
1.14
0.70
3.6
2.8
2.04
2.22
mmol/l
0.26
67
651
465
4371
1.07
0.70
1.1
1.1
—
—
—
0
0
619
5871
1.06
0.69
1.5
1.6
285.01
312.72
mu/l
1.10
552
5221
2974
30337
0.97
0.69
2.2
2.2
—
—
—
0
0
192
1740
1.11
0.69
2.8
2.4
—
—
—
0
0
41
328
1.25
0.68
3.4
3.2
—
—
—
0
0
9
59
1.53
0.68
1.1
1.0
—
—
—
0
0
783
7480
1.05
0.68
1.3
1.4
—
—
—
0
0
86
995
0.86
0.68
3.9
4.3
101.89
109.45
u/ml
0.04
38
338
209
1906
1.10
0.67
1.1
1.1
—
—
—
0
0
52
429
1.21
0.66
1.3
1.5
29401.38
32407.90
e6/l
0.04
34
298
264
2435
1.09
0.66
5.4
6.3
24.18
24.28
mmol/l
0.17
253
2301
190
1727
1.10
0.65
1.3
1.3
19.34
20.07
u/ml
—
5
38
257
2785
0.92
0.65
2.3
2.2
—
—
—
0
0
82
708
1.16
0.64
3.2
2.4
—
—
—
0
0
5
29
1.72
0.64
1.2
1.2
—
—
—
0
0
198
1807
1.10
0.63
3.8
3.1
1.58
1.35
%
1.68
198
1795
471
4447
1.06
0.63
3.6
3.0
1.23
1.23
mmol/l
0.80
409
3903
184
1674
1.10
0.63
1.3
1.2
285.97
265.83
u/ml
0.49
130
1133
699
6676
1.05
0.63
3.4
3.4
4.60
4.55
pmol/l
0.62
627
6053
208
1905
1.09
0.62
1.1
1.1
—
—
—
0
0
37
297
1.25
0.62
2.6
3.2
0.78
0.79
nmol/l
0.11
24
223
8
49
1.63
0.62
1.0
1.7
—
—
—
0
0
28
358
0.78
0.62
2.8
3.0
—
—
—
0
0
10
152
0.66
0.61
1.0
1.0
0.10
0.16
u/ml
—
5
83
32
253
1.27
0.60
1.2
1.3
6.01
6.15
mmol/l
0.09
27
233
13
88
1.48
0.60
1.8
2.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
725
6942
1.05
0.59
1.4
1.4
—
—
—
0
0
193
1767
1.09
0.59
3.8
3.1
0.61
0.66
%
1.93
193
1757
822
8556
0.96
0.59
1.5
1.4
—
—
—
0
0
319
3410
0.93
0.59
1.7
1.7
—
—
—
0
0
217
1998
1.09
0.59
1.3
1.3
111.82
154.61
titre
0.29
22
191
174
1586
1.10
0.59
4.5
4.7
0.88
0.94
%
1.14
164
1479
11
72
1.53
0.59
1.1
2.0
0.73
0.92
u/field
0.26
11
72
169
1539
1.10
0.58
3.3
4.2
—
—
—
0
0
74
853
0.87
0.58
1.4
1.4
0.40
0.37
g/l
0.22
50
603
10
64
1.56
0.58
1.0
1.0
0.10
0.83
u/ml
—
5
33
175
1597
1.10
0.58
4.5
4.6
1.93
1.75
%
0.97
164
1488
74
852
0.87
0.58
1.4
1.4
2.78
3.02
g/l
0.80
49
598
74
852
0.87
0.58
1.4
1.4
6.77
6.59
g/l
0.12
49
601
258
2396
1.08
0.57
1.2
1.2
—
—
—
0
0
133
1199
1.11
0.56
1.4
1.4
—
—
—
0
0
228
2110
1.08
0.56
1.1
1.1
2.50
1.56
u/ml
0.54
101
1024
241
2237
1.08
0.55
1.1
1.1
—
—
—
0
0
68
588
1.16
0.55
1.1
1.1
—
—
—
0
0
176
1613
1.09
0.54
1.2
1.2
—
—
—
0
0
53
450
1.18
0.53
2.1
2.3
—
—
—
0
0
95
843
1.13
0.53
1.2
1.4
—
—
—
0
0
84
741
1.13
0.52
1.2
1.2
—
—
—
0
0
81
713
1.14
0.52
6.2
3.6
60.27
62.27
%
0.37
81
713
54
461
1.17
0.52
1.6
1.6
36.43
40.82
%
0.33
32
272
38
314
1.21
0.51
1.1
1.1
—
—
—
0
0
561
5865
0.95
0.51
1.5
1.5
—
—
—
0
0
546
5711
0.95
0.51
1.4
1.4
—
—
—
0
0
665
6920
0.96
0.50
1.3
1.3
—
—
—
0
0
547
5717
0.95
0.50
1.4
1.5
—
—
—
0
0
79
697
1.13
0.50
2.7
3.4
—
—
—
0
0
60
519
1.16
0.50
1.6
1.7
280.89
282.40
mosm/kgh2o
0.21
46
425
364
3445
1.06
0.49
1.2
1.2
10.17
11.55
u/l
1.39
304
2892
17
224
0.76
0.49
1.4
1.5
—
—
—
0
0
23
180
1.28
0.49
1.0
1.0
—
—
—
0
0
199
1845
1.08
0.49
1.1
1.1
4.60
4.15
u/ml
0.11
90
853
26
207
1.26
0.49
1.3
1.4
—
—
—
0
0
1214
12480
0.97
0.48
3.3
3.3
385.02
498.74
mg/l
0.38
773
7688
27
334
0.81
0.48
1.6
1.7
—
—
—
0
0
7
108
0.65
0.48
1.1
1.0
—
—
—
0
0
40
335
1.19
0.48
1.7
1.9
8.64
9.62
mg/l
0.57
31
276
6717
67568
0.97
0.48
13.6
12.7
332.24
331.89
g/l
2.99
6672
67091
118
1300
0.91
0.48
3.7
3.3
27.77
21.43
mg/l
0.61
57
776
21
163
1.29
0.48
1.7
1.7
—
—
—
0
0
31
377
0.82
0.48
1.7
1.3
84.00
174.22
nmol/24h
0.78
31
377
59
512
1.15
0.47
1.7
1.4
—
—
—
0
0
7
47
1.49
0.47
1.0
1.2
—
—
—
0
0
76
856
0.89
0.46
1.4
1.5
—
—
—
0
0
7
49
1.43
0.46
1.9
3.9
—
—
—
0
0
19
147
1.29
0.45
1.1
1.1
—
—
—
0
0
943
9148
1.03
0.45
1.2
1.2
—
—
—
0
0
12
164
0.73
0.45
1.0
1.1
—
—
—
0
0
891
8636
1.04
0.44
1.2
1.2
174.45
152.10
iu/ml
0.68
351
3460
12
86
1.40
0.44
1.2
1.2
—
—
—
0
0
197
1837
1.07
0.44
3.3
2.8
0.18
0.32
g/l
4.56
73
733
121
1323
0.91
0.43
2.4
1.9
4.77
1.64
ug/l
0.92
103
1166
22
274
0.80
0.43
1.5
2.2
296.67
183.03
e6/l
0.34
12
152
11
78
1.41
0.43
2.7
2.2
—
—
—
0
0
40
340
1.18
0.43
2.3
2.4
—
—
—
0
0
107
973
1.10
0.42
2.1
2.0
—
—
—
0
0
80
716
1.12
0.42
1.0
1.0
—
—
—
0
0
64
565
1.13
0.42
3.9
4.1
5.94
7.15
mmol/l
2.75
55
463
186
1735
1.07
0.42
1.1
1.1
4.55
4.51
u/ml
0.01
72
722
123
1128
1.09
0.41
1.7
1.7
6632.68
8427.15
e6/l
0.62
92
845
101
918
1.10
0.41
1.6
1.4
—
—
—
0
0
48
416
1.15
0.41
1.4
1.3
—
—
—
0
0
11
150
0.73
0.41
1.3
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
0.23
—
0
9
63
709
0.89
0.40
1.1
1.2
0.44
1.44
u/ml
1.59
23
376
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
49
560
0.87
0.39
5.8
6.6
—
—
—
0
0
7
105
0.67
0.39
6.1
4.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
0.10
—
0
14
14
106
1.32
0.39
1.1
1.2
—
—
—
0
0
15
115
1.30
0.38
1.5
1.4
—
—
—
0
0
1377
13476
1.03
0.38
1.4
1.5
—
—
—
0
0
11
80
1.38
0.38
1.5
1.1
—
—
—
0
0
133
1433
0.93
0.36
1.4
1.3
1.43
1.29
nmol/l
0.33
116
1225
209
2215
0.94
0.36
7.9
6.9
—
—
—
0
0
6
42
1.43
0.35
1.2
1.2
—
—
—
0
0
516
4981
1.04
0.35
1.1
1.1
72.77
221.45
titre
3.11
13
127
18
144
1.25
0.35
1.2
1.8
—
—
—
0
0
71
641
1.11
0.35
1.2
1.2
—
—
—
0
0
348
3633
0.96
0.35
1.1
1.1
—
—
—
0
0
283
2966
0.95
0.34
1.1
1.1
3.66
4.54
u/ml
0.34
59
477
25
209
1.20
0.33
1.1
1.1
—
—
—
0
0
85
777
1.09
0.33
1.0
1.1
0.33
1.53
u/ml
1.54
22
239
6
46
1.30
0.33
1.7
1.4
—
—
—
0
0
6
86
0.70
0.33
2.8
2.3
—
—
—
0
0
392
3773
1.04
0.32
3.7
3.3
79.97
74.57
ng/l
0.51
359
3380
78
712
1.10
0.32
1.0
1.0
0.82
0.33
u/ml
0.39
14
143
113
1049
1.08
0.32
3.2
3.4
—
—
—
0
0
349
3352
1.04
0.32
1.7
1.7
—
—
—
0
0
163
1728
0.94
0.30
1.5
1.5
7.01
6.61
mmol/l
0.93
155
1577
67
609
1.10
0.30
1.8
1.7
48.66
49.37
%
0.05
41
375
140
1314
1.07
0.30
2.3
2.1
405.62
320.89
ug/l
0.24
127
1153
30
259
1.16
0.29
1.0
1.1
—
—
—
0
0
228
2390
0.95
0.29
1.2
1.3
—
—
—
0
0
42
472
0.89
0.29
1.0
1.1
0.08
2.43
nmol/l
—
6
84
289
2773
1.04
0.29
2.0
2.2
4.46
5.05
umol/l
0.84
205
2007
16
130
1.23
0.28
1.9
1.7
—
—
—
0
0
294
2827
1.04
0.27
2.4
2.4
0.24
0.23
e6/l
0.10
282
2694
652
6357
1.03
0.27
1.2
1.3
282.96
182.21
u/ml
0.90
605
5891
162
1709
0.95
0.27
1.0
1.1
2.44
2.86
u/ml
0.26
96
954
9
120
0.75
0.27
3.8
4.9
—
—
—
0
0
18
215
0.84
0.27
1.1
1.0
0.14
0.99
u/ml
1.00
11
146
128
1205
1.06
0.26
1.4
1.3
33.96
56.46
u/ml
—
8
79
163
1717
0.95
0.26
1.1
1.1
—
—
—
0
0
60
548
1.10
0.26
1.5
1.7
—
—
—
0
0
112
1193
0.94
0.26
1.1
1.1
128.64
8619.60
iu/ml
0.63
29
312
137
1294
1.06
0.26
1.2
1.1
—
—
—
0
0
165
1736
0.95
0.26
3.2
2.7
—
—
—
0
0
49
444
1.10
0.25
2.8
2.8
157.83
57.49
mg/l
0.39
34
313
18
151
1.19
0.25
1.1
1.4
—
—
—
0
0
111
1044
1.06
0.24
4.0
2.6
—
—
—
0
0
22
255
0.86
0.24
1.0
1.1
4.96
5.03
mg/g
0.04
22
240
11
87
1.26
0.24
1.0
1.1
—
—
—
0
0
6
85
0.71
0.24
1.0
1.0
0.31
0.59
u/ml
—
6
77
44
398
1.11
0.23
3.1
2.6
122.05
92.43
nmol/l
0.25
44
391
63
581
1.08
0.23
2.4
2.6
—
—
—
0
0
134
1271
1.06
0.23
3.2
2.3
—
—
—
0
0
37
332
1.11
0.23
1.1
1.2
—
—
—
0
0
65
601
1.08
0.23
1.4
1.5
5.80
5.81
mmol/l
0.01
50
490
29
256
1.13
0.23
1.2
1.4
14180.83
2976.71
e6/l
0.47
24
178
109
1028
1.06
0.23
1.5
1.3
—
—
—
0
0
131
1243
1.05
0.22
1.2
1.3
—
—
—
0
0
129
1224
1.05
0.22
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
51
556
0.92
0.22
3.0
2.5
565.82
514.00
e6/l
0.54
45
456
5
41
1.22
0.22
1.0
1.2
286.80
152.77
ug/g
—
5
31
263
2540
1.04
0.22
3.2
2.7
5.21
5.08
kpa
1.71
252
2433
34
378
0.90
0.21
1.9
2.1
—
—
—
0
0
79
739
1.07
0.21
1.3
1.4
—
—
—
0
0
5
42
1.19
0.21
1.0
1.2
—
—
—
0
0
122
1158
1.05
0.21
2.9
3.8
3.79
3.76
mmol/l
0.32
122
1148
256
2474
1.04
0.21
1.1
1.1
2.82
1.78
u/ml
0.70
128
1209
1545
15263
1.01
0.20
2.2
2.0
1870.37
2429.17
umol/l
0.44
1405
13869
60
557
1.08
0.20
1.1
1.2
7.00
15.87
u/ml
—
6
67
82
872
0.94
0.20
1.2
1.2
—
—
—
0
0
149
1557
0.96
0.20
3.3
2.6
24.73
24.65
mmol/l
0.13
142
1455
9
111
0.81
0.20
1.1
1.1
—
—
—
0
0
22
193
1.14
0.19
2.0
1.6
8.00
8.42
ug/l
0.23
22
193
24
212
1.13
0.19
1.3
1.5
—
—
—
0
0
140
1339
1.05
0.19
1.1
1.1
—
—
—
0
0
22
249
0.88
0.19
1.3
1.6
—
—
—
0
0
136
1421
0.96
0.18
1.4
1.4
31.43
31.56
nmol/l
0.02
128
1308
73
686
1.06
0.18
1.2
1.1
1.04
1.05
ratio
0.11
22
260
21
238
0.88
0.18
1.0
1.2
—
—
—
0
0
206
1990
1.04
0.18
1.3
1.3
1291.82
954.53
titre
0.33
11
86
21
185
1.14
0.18
7.7
2.3
12.27
9.82
mmol/l
1.73
21
179
172
1784
0.96
0.17
1.1
1.2
3.52
3.58
mmol/l
0.33
166
1673
51
548
0.93
0.17
3.1
2.5
0.25
0.23
e9/l
0.24
46
457
20
176
1.14
0.17
1.2
1.1
—
—
—
0
0
40
434
0.92
0.17
1.3
1.2
63.43
70.25
%
—
7
44
5
67
0.75
0.17
1.0
1.2
—
—
—
0
0
33
301
1.10
0.17
1.5
2.2
1.10
1.42
nmol/l
1.12
28
252
53
566
0.94
0.16
1.1
1.1
—
—
—
0
0
6
80
0.75
0.15
1.0
1.1
11.78
12.62
pmol/l
—
6
80
32
293
1.09
0.15
1.6
1.8
—
—
—
0
0
569
5594
1.02
0.15
1.2
1.2
—
—
—
0
0
16
182
0.88
0.15
1.0
1.0
—
—
—
0
0
65
615
1.06
0.14
1.2
1.2
—
—
—
0
0
49
459
1.07
0.14
2.8
2.7
0.78
1.29
g/24h
1.98
26
243
7
88
0.80
0.14
2.6
2.1
1.18
1.19
mmol/l
—
7
81
25
275
0.91
0.14
1.2
1.2
6.43
5.75
nmol/l
0.52
25
260
228
2220
1.03
0.14
1.0
1.1
5.85
4.92
u/ml
0.34
108
1158
43
460
0.93
0.14
1.5
1.4
4.30
5.19
u/l
1.88
33
398
274
2805
0.98
0.14
1.8
1.9
20.62
20.60
s
0.03
228
2336
30
326
0.92
0.14
1.3
1.1
—
—
—
0
0
81
774
1.05
0.13
1.3
1.3
—
—
—
0
0
1290
13021
0.99
0.13
3.9
3.8
13.18
10.29
mg/mmol
0.67
814
8144
27
294
0.92
0.13
2.5
2.1
1.82
1.16
ug/l
0.67
27
281
27
294
0.92
0.13
1.1
1.2
—
—
—
0
0
13
113
1.15
0.13
2.3
2.1
—
—
—
0
0
1660
16475
1.01
0.12
1.6
1.6
1.35
1.33
mmol/l
0.28
1434
14423
221
2159
1.02
0.12
1.3
1.3
46.37
37.62
u/ml
0.38
30
222
41
436
0.94
0.12
1.5
1.4
—
—
—
0
0
76
728
1.04
0.12
2.6
2.4
1.41
1.36
e9/l
0.11
70
636
214
2090
1.02
0.12
1.0
1.1
1.65
0.96
u/ml
0.51
80
865
45
476
0.95
0.11
1.0
1.1
13.12
9.87
u/ml
—
6
87
256
2508
1.02
0.11
3.2
2.7
7.41
7.41
ph
0.30
45
337
56
533
1.05
0.11
1.2
1.2
219.09
207.21
titre
0.04
11
104
12
105
1.14
0.11
1.2
1.3
—
—
—
0
0
15
134
1.12
0.10
1.7
1.1
—
—
—
0
0
80
831
0.96
0.10
1.2
1.5
—
—
—
0
0
31
290
1.07
0.10
1.3
1.1
—
—
—
0
0
36
382
0.94
0.10
1.1
1.1
14.01
9.36
u/ml
0.75
18
243
205
2007
1.02
0.10
1.2
1.3
517.99
450.79
mg/l
0.37
196
1922
5
44
1.14
0.10
1.6
3.1
—
—
—
0
0
5
44
1.14
0.10
1.6
3.1
—
—
—
0
0
64
614
1.04
0.10
1.1
1.2
—
—
—
0
0
18
197
0.91
0.09
2.0
1.4
—
—
—
0
0
5
46
1.09
0.09
1.2
1.0
—
—
—
0
0
79
763
1.04
0.09
1.0
1.0
1.13
0.79
u/ml
0.15
14
169
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
74
766
0.97
0.09
2.4
2.4
1.40
1.35
mmol/l
0.23
74
747
105
1079
0.97
0.08
2.8
2.8
0.95
0.84
nmol/l
0.78
92
905
40
420
0.95
0.08
1.0
1.0
—
—
—
0
0
39
371
1.05
0.08
1.2
1.2
—
—
—
0
0
24
224
1.07
0.08
1.3
1.4
26120.00
77551.53
e6/l
0.73
18
122
94
967
0.97
0.08
1.2
1.2
0.49
1.72
nmol/l
0.53
89
937
91
884
1.03
0.08
1.1
1.2
33.03
35.90
mg/l
0.41
67
745
68
657
1.04
0.08
2.8
3.1
—
—
—
0
0
70
677
1.03
0.08
1.0
1.1
11.23
7.91
iu/ml
0.46
23
213
28
297
0.94
0.08
1.2
1.1
—
—
—
0
0
14
127
1.10
0.07
1.2
1.2
—
—
—
0
0
1258
12506
1.01
0.07
1.5
1.6
30402685.45
30631306.37
pmol/l
0.01
1069
10953
174
1773
0.98
0.07
1.2
1.4
689.03
3484.10
e6/l
0.73
141
1460
16
174
0.92
0.07
1.2
1.1
—
—
—
0
0
16
174
0.92
0.07
1.2
1.1
—
—
—
0
0
16
174
0.92
0.07
1.2
1.1
—
—
—
0
0
174
1772
0.98
0.07
1.2
1.3
80.98
23.77
e6/l
0.38
137
1386
149
1520
0.98
0.07
1.3
1.2
—
—
—
0
0
7
80
0.87
0.07
3.0
6.8
—
—
—
0
0
14
153
0.91
0.07
1.1
1.1
—
213.33
—
0
9
17
157
1.08
0.07
1.1
1.0
—
—
—
0
0
170
1671
1.02
0.06
1.2
1.3
—
—
—
0
0
59
571
1.03
0.06
1.2
1.2
15.31
20.70
u/l
0.73
53
499
88
858
1.03
0.06
1.0
1.1
194.84
205.17
mg/l
0.46
73
753
78
759
1.03
0.06
3.4
3.5
198.12
536.86
u/ml
0.47
72
701
53
548
0.97
0.06
1.0
1.1
1450.12
1490.14
miu/ml
0.09
53
548
151
1484
1.02
0.06
3.1
3.7
35.16
26.64
u/ml
0.46
140
1437
27
284
0.95
0.06
2.4
2.4
594.40
616.98
ml
0.14
20
227
42
436
0.96
0.06
1.7
1.8
4.73
1.94
u/field
0.78
22
223
15
139
1.08
0.05
1.1
1.1
—
—
—
0
0
74
723
1.02
0.05
1.1
1.0
—
—
—
0
0
62
605
1.02
0.04
2.0
1.7
—
—
—
0
0
17
160
1.06
0.04
1.6
1.7
—
—
—
0
0
38
368
1.03
0.04
1.2
1.1
—
—
—
0
0
80
815
0.98
0.04
1.6
1.5
862.52
533.12
pmol/l
0.43
73
728
14
131
1.07
0.03
2.5
2.4
407.00
821.96
e6/l
—
8
89
36
349
1.03
0.03
1.4
1.6
1.71
2.44
u/field
0.51
24
255
87
884
0.98
0.03
2.0
1.8
32.73
51.87
mu/l
1.82
82
811
53
519
1.02
0.03
1.1
1.1
—
—
—
0
0
35
360
0.97
0.03
1.3
1.3
133.82
142.14
mmol/24h
0.34
35
360
12
112
1.07
0.03
1.8
2.8
—
—
—
0
0
11
118
0.93
0.02
2.9
2.2
1075.00
23248.98
e6/l
—
5
62
289
2907
0.99
0.02
1.5
1.5
0.54
0.50
nmol/l
0.25
235
2354
38
389
0.98
0.02
1.2
1.2
—
—
—
0
0
10
107
0.93
0.02
3.1
2.2
—
—
—
0
0
71
701
1.01
0.01
1.3
1.3
—
—
—
0
0
25
257
0.97
0.01
1.6
1.5
2.40
4.52
%
—
5
54
47
477
0.99
0.01
1.5
1.4
67.13
68.03
umol/l
0.15
47
477
72
713
1.01
0.01
1.7
1.6
—
—
—
0
0
12
114
1.05
0.00
2.4
2.6
—
—
—
0
0
737
7361
1.00
0.00
2.0
2.0
387.42
376.65
nmol/l
0.81
681
6792
38
374
1.02
0.00
1.2
1.1
—
—
—
0
0
12
123
0.98
0.00
1.0
1.3
0.85
122.30
mg/l
—
6
92
47
467
1.01
0.00
2.0
2.1
—
—
—
0
0
18
184
0.98
0.00
3.2
2.2
—
—
—
0
0
70
704
0.99
0.00
2.5
2.5
6.86
7.10
mmol/l
0.36
70
687
23
225
1.02
0.00
2.5
3.0
7.42
7.43
ph
0.09
11
48
25
255
0.98
0.00
1.2
1.2
27.80
15.13
%
—
5
40
90
898
1.00
0.00
1.7
1.5
—
—
—
0
0
337
3371
1.00
0.00
1.3
1.3
3.79
3.17
ug/l
0.29
312
3114
42
419
1.00
0.00
2.0
1.6
1.48
15.71
nmol/l
0.59
34
346
11
109
1.01
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.6
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
12.3
9.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
160.20
—
0
5
20
200
1.00
-0.00
1.5
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
79
0.89
-0.00
1.6
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.58
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
319.00
—
0
5

Mortality – FinRegistry

Association

Association between endpoint N14_CERVICAL_HSIL and mortality.

Females

Parameter HR [95% CI] p-value
N14_CERVICAL_HSIL 1.314 [1.17, 1.48] < 0.001
Birth year 0.991 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 1401 out of 43721 females with N14_CERVICAL_HSIL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_CERVICAL_HSIL.

N-year risk Females Males
1 0.103% No data
5 0.634% No data
10 1.524% No data
15 3.107% No data
20 5.718% No data

Relationships between endpoints

Index endpoint: N14_CERVICAL_HSIL – HSIL lesion of the cervix uteri

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data