HSIL lesion of the cervix uteri, vagina or vulva

N14_FEMALE_GENITAL_HSIL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

8982

4. Check minimum number of events

None

8982

5. Include endpoints

None

8982

6. Filter based on genotype QC (FinnGen only)

8982

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 57280 57280 -
Only index persons 55872 55872 -
Unadjusted period prevalence (%)
Whole population 1.64 1.64 -
Only index persons 2.05 2.05 -
Median age at first event (years)
Whole population - 35.16 -
Only index persons - 35.02 -

-FinnGen-

Key figures

All Female Male
Number of individuals 8982 8982 -
Unadjusted period prevalence (%) 3.06 3.06 -
Median age at first event (years) 35.60 35.60 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
7974
Matched controls
79740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
+∞
323.0
381
*
ULA02
NOMESCO Finland
Kolposcopy
43.6
323.0
6177
5822
A63.0
ICD-10 Finland
Anogenital (venereal) warts
5.7
323.0
1068
2117
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
24.8
323.0
4413
3801
LEB00
NOMESCO Finland
Biopsy of vagina
12.1
323.0
635
565
N87.0
ICD-10 Finland
Mild cervical dysplasia
9.2
323.0
1114
1388
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
34.1
323.0
5864
6007
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
116.1
323.0
4929
1093
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
378.8
323.0
2296
85
LDA10
NOMESCO Finland
Curettage of cervix uteri
18.8
323.0
2523
1912
C539, 6666, 0
ICD-O-3
NA
197.8
323.0
1123
66
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
14.4
323.0
4930
8065
N87.1
ICD-10 Finland
Moderate cervical dysplasia
15476.4
323.0
3560
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
13792.4
323.0
3796
5
ZXC00
NOMESCO Finland
Use of diathermy
36.1
302.9
395
115
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
73.5
283.7
325
46
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
+∞
278.8
266
*
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
2485.7
260.6
251
*
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
+∞
254.5
243
*
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
+∞
247.1
236
*
8326
FHL
Batch conization
79.5
243.4
276
36
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
7.2
239.3
616
918
6221C
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI GRAVIS]
+∞
217.7
208
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.1
207.5
4034
26300
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
+∞
191.4
183
*
6221B
ICD-9 Finland
Noninflammatory disorders of cervix, Dysplasia of cervix (uteri)[DYSPLASIA CERVICIS UTERI MODERATA]
+∞
184.0
176
*
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
22.3
183.6
272
126
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
10.7
182.3
366
358
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
382.0
150.6
151
*
G01AA10
ATC
clindamycin; vaginal
2.0
139.6
2176
12407
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
+∞
135.8
130
*
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
6.3
132.3
370
610
8077/2-C53.1
ICD-O-3
Squamous intraepithelial neoplasia, high grade of exocervix
438.1
130.3
130
*
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
1196.5
121.2
118
*
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
1165.6
118.1
115
*
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
15.1
111.3
189
128
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
1073.0
108.7
106
*
2331A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Cervix uteri
+∞
99.1
95
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
7.4
94.2
233
323
N89.0
ICD-10 Finland
Mild vaginal dysplasia
14.0
88.2
154
112
LFC00
NOMESCO Finland
Partial excision of vulva
27.0
84.1
117
44
N90.0
ICD-10 Finland
Mild vulvar dysplasia
15.7
74.7
124
80
R87.2
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of other drugs, medicaments and biological substances
26.2
72.2
101
39
X86
ICPC
Abnormal cervix smear
4.9
68.4
236
498
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
51.1
67.3
81
16
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
67.2
1382
8369
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
7.0
67.2
171
248
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
9.6
65.5
137
145
R87.1
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of hormones
34.9
63.9
83
24
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
59.0
2549
18755
P01AB01
ATC
metronidazole; oral, rectal
1.5
58.3
3432
26991
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.4
57.8
524
2267
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.7
56.5
1379
8745
D06BB10
ATC
imiquimod; topical
2.6
53.4
427
1727
D06BB04
ATC
podophyllotoxin; topical
2.1
52.0
676
3446
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
16.9
51.1
82
49
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
16.3
38.9
63
39
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.6
35.4
1162
7870
C53.01
ICD-10 Finland
Squamous cell carcinoma of the endocervix
14.0
35.0
60
43
TLC02
NOMESCO Finland
Simple extraction of IUD
1.9
34.6
575
3196
8140/2-C53.0
ICD-O-3
Adenocarcinoma in situ, NOS, of endocervix
+∞
32.3
31
*
WX110
NOMESCO Finland
Local anesthesy
1.3
32.0
5403
48653
8140/2-C53.1
ICD-O-3
Adenocarcinoma in situ, NOS, of exocervix
+∞
31.3
30
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
30.8
2179
17144
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
14.1
30.5
52
37
N07BA03
ATC
varenicline; oral
2.0
29.6
411
2143
SPAT1193
SPAT
Pap smear
1.5
29.1
1278
9192
R2110
NOMESCO Finland
Giving the first information
1.7
28.6
684
4253
LDB00
NOMESCO Finland
Excision of lesion of cervix uteri
3.1
28.6
159
514
O34.4
ICD-10 Finland
Maternal care for other abnormalities of cervix
8.6
28.3
62
73
N87
ICD-10 Finland
Dysplasia of cervix uteri
15.6
27.6
45
29
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
27.3
1830
14214
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.5
27.3
1251
9067
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
2.5
26.9
222
914
R87.9
ICD-10 Finland
Abnormal findings in specimens from female genital organs, unspecified abnormal finding
8.4
26.7
59
71
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
26.4
695
4438
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
7.3
25.8
62
85
N76.0
ICD-10 Finland
Acute vaginitis
1.6
24.8
723
4733
X23
ICPC
Fear sexually transm dis female
1.6
24.7
611
3836
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.6
24.4
648
4143
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
4.4
23.8
88
204
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.5
23.6
837
5732
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
46.8
23.3
28
6
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
22.9
22
*
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
25.9
22.6
31
12
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
2.1
22.3
271
1338
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
7.4
22.3
53
72
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
22.0
210
933
G01AF01
ATC
metronidazole; vaginal
1.5
21.7
838
5845
X92
ICPC
Chlamydia infection genital female
2.6
21.6
162
636
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
21.2
421
2480
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
20.8
20
*
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
14.4
19.8
33
23
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.5
19.7
614
4080
LCH11
NOMESCO Finland
Pharmacologic abortion
1.6
19.6
532
3414
N02AX02
ATC
tramadol; systemic, rectal
1.3
19.6
2346
19650
M03BX02
ATC
tizanidine; oral
1.2
19.4
4792
43651
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
2.0
19.3
240
1202
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.4
18.6
984
7288
N02BE01
ATC
paracetamol; systemic, rectal
1.3
18.2
6313
59583
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
21.7
18.1
26
12
SPAT1283
SPAT
Restricted health certificate
1.3
18.0
1858
15234
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
18.1
17.7
27
15
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
1.8
17.7
334
1937
K05.31
ICD-10 Finland
Periodontitis pronounced
1.6
17.5
418
2597
LCD10
NOMESCO Finland
Vaginal hysterectomy
1.9
17.4
269
1461
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
17.0
3095
27100
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
2.2
16.9
173
797
Z64.0
ICD-10 Finland
Problems related to unwanted pregnancy
1.7
16.9
330
1936
SPAT1308
SPAT
Sexual health counselling
1.3
16.7
1457
11663
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
16.7
16
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
16.3
2175
18363
J01DB01
ATC
cefalexin; oral
1.3
16.2
6176
58343
J02AC01
ATC
fluconazole; systemic
1.2
16.2
3863
34724
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
1.5
16.1
567
3870
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
16.1
2732
23698
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
16.0
5582
52155
M54.5
ICD-10 Finland
Low back pain
1.2
16.0
2332
19887
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
15.7
7159
69051
8010/2-C53.9
ICD-O-3
Carcinoma in situ, NOS, of cervix uteri
+∞
15.6
15
*
W11
ICPC
Contraception oral
1.4
15.3
950
7212
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
1.4
15.3
730
5297
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
1.7
15.2
308
1828
R87.3
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of substances chiefly nonmedicinal as to source
23.4
15.1
21
9
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
15.0
189
953
J01CA08
ATC
pivmecillinam; oral
1.2
14.9
3806
34328
Z72.0
ICD-10 Finland
Tobacco use
2.1
14.7
164
785
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
14.6
1570
12892
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
7.3
14.4
34
47
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
1.7
14.0
288
1718
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
30.1
13.9
18
6
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
3.7
13.8
60
165
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
8.6
13.7
29
34
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
1.3
13.6
1490
12243
6230B
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE MODERATA]
+∞
13.5
13
*
N05CF01
ATC
zopiclone; oral
1.2
13.4
1711
14314
N06AX11
ATC
mirtazapine; oral
1.2
13.3
2056
17574
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
2.8
13.2
83
297
4044
NOMESCO Finland
NA
12.1
13.1
23
19
WX002
NOMESCO Finland
Sedation and analgesia
1.3
13.0
950
7393
SPAT1263
SPAT
Sampling
1.2
12.9
2904
25748
N93.0
ICD-10 Finland
Postcoital and contact bleeding
2.6
12.9
93
362
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
12.6
1544
12841
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
12.5
4047
37050
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
12.5
12
*
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.6
12.4
313
1976
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
12.2
3623
32890
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.6
12.1
282
1747
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
46.7
11.9
14
*
WX290
NOMESCO Finland
Other blockade of nerve
1.2
11.9
3593
32644
J01AA02
ATC
doxycycline; systemic
1.2
11.8
5531
52183
R87.0
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of enzymes
5.6
11.7
33
59
J05AB01
ATC
aciclovir; systemic
1.2
11.6
1450
12080
SPAT1312
SPAT
General health counselling
1.2
11.6
2167
18833
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
11.5
2843
25347
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
11.5
2689
23866
C53.12
ICD-10 Finland
Adenocarcinoma of the exocervix
13.6
11.4
19
14
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.3
11.4
1034
8279
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
2.2
11.4
109
493
X15
ICPC
Vaginal symptom/complaint other
1.5
11.3
349
2316
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.2
11.3
1389
11552
K02.1
ICD-10 Finland
Caries of dentine
1.2
11.2
4376
40530
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
1.9
11.1
163
875
ZXC10
NOMESCO Finland
Use of laser
2.1
10.9
123
598
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.5
10.8
315
2061
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
10.8
2163
18895
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
3.8
10.8
44
116
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
3.9
10.7
43
112
8070/3-C53.1
ICD-O-3
Squamous cell carcinoma, NOS, of exocervix
17.8
10.7
16
9
EBA00
NOMESCO Finland
Extraction of tooth
1.2
10.7
2039
17727
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
10.7
159
858
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
1.8
10.6
167
920
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.2
10.6
1604
13627
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
10.6
2376
20968
W14
ICPC
Contraception female other
1.4
10.6
510
3707
L04AX01
ATC
azathioprine; systemic
1.6
10.5
258
1618
D82
ICPC
Teeth/gum disease
1.2
10.5
2618
23314
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
10.5
3817
35077
R74
ICPC
Upper respiratory infection acute
1.2
10.4
2521
22384
LEB10
NOMESCO Finland
Excision of lesion of vagina
3.1
10.3
55
179
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
10.3
1934
16775
N93.9
ICD-10 Finland
Abnormal uterine and vaginal bleeding, unspecified
1.7
10.3
197
1155
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
18.8
10.2
15
8
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
10.2
1007
8150
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.2
10.2
2666
23826
6350C
ICD-9 Finland
Legally induced abortion, Complicated by genital tract and pelvic infection[ABORTUS PROV LEGAL SINE COMPL,SOSIAALISET SYYT]
1.4
10.1
415
2932
8327
FHL
Amputation portionis and conization
40.1
10.0
12
*
T74.1
ICD-10 Finland
Physical abuse
1.9
9.9
145
781
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
9.9
5343
50547
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
3.8
9.8
40
106
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
1.6
9.8
258
1653
L04AA06
ATC
mycophenolic acid; systemic
2.3
9.7
86
377
X85
ICPC
Cervical disease NOS
6.8
9.6
23
34
N90.4
ICD-10 Finland
Leukoplakia of vulva
3.9
9.6
37
94
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
9.5
3892
35968
C53.00
ICD-10 Finland
Malignant tumor of endocervix without histology
10.0
9.5
18
18
M79.6
ICD-10 Finland
Pain in limb
1.2
9.4
2255
19965
D06.7
ICD-10 Finland
Carcinoma in situ: Other parts of cervix
+∞
9.4
9
*
8077/2-C53.0
ICD-O-3
Squamous intraepithelial neoplasia, high grade of endocervix
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.2
9.4
4077
37841
M01AB05
ATC
diclofenac; systemic, rectal
1.2
9.4
4635
43437
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
9.3
2565
22968
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
2.5
9.2
71
290
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
3.5
9.1
40
114
R87.8
ICD-10 Finland
Abnormal findings in specimens from female genital organs, other abnormal findings
3.2
9.0
45
141
7950A
ICD-9 Finland
Nonspecific abnormal histological and immunological findings, Nonspecific abnormal Papanicolaou smear of cervix
7.0
9.0
21
30
SDE04
NOMESCO Finland
Periodontal treatment by dental hygienist, very extensive
1.3
9.0
600
4606
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.2
9.0
1661
14367
SPAT1301
SPAT
No procedures
1.2
8.9
1790
15595
J01DA01
ATC
[U] cefalexin; systemic
1.2
8.9
4538
42544
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.3
8.8
632
4895
M03BC01
ATC
orphenadrine (citrate); systemic
1.2
8.8
1743
15168
N06AB04
ATC
citalopram; systemic
1.2
8.7
1394
11884
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
8.7
1112
9261
Z30.0
ICD-10 Finland
General counselling and advice on contraception
1.3
8.7
660
5157
J01MA02
ATC
ciprofloxacin; systemic
1.2
8.7
2025
17869
LDA96
NOMESCO Finland
Other biopsy of cervix uteri
14.0
8.7
14
10
B01AB10
ATC
tinzaparin; parenteral
1.5
8.7
310
2131
WF002
NOMESCO Finland
Radical radiotherapy
1.9
8.6
116
607
L03
ICPC
Low back symptom/complaint
1.2
8.6
1544
13308
N93.8
ICD-10 Finland
Other specified abnormal uterine and vaginal bleeding
1.8
8.6
147
836
O04.6
ICD-10 Finland
Medical abortion, complete or unspecified, complicated by delayed or excessive haemorrhage
1.9
8.6
120
639
AA1AD
NOMESCO Finland
CT of head and brain
1.3
8.5
894
7286
N05BA04
ATC
oxazepam; oral
1.2
8.4
1593
13794
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
2.4
8.4
71
303
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
90.1
8.4
9
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
1.6
8.3
225
1452
XLA10
NOMESCO Finland
NA
1.4
8.3
410
2997
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
8.2
2668
24141
J05AB11
ATC
valaciclovir; oral
1.3
8.2
806
6511
H02AB06
ATC
prednisolone; systemic
1.2
8.2
2846
25879
SPAT1192
SPAT
Gynaecological examination
1.2
8.2
1115
9345
J01FF01
ATC
clindamycin; systemic
1.2
8.1
1586
13766
M01AH05
ATC
etoricoxib; oral
1.1
8.1
3987
37172
X14
ICPC
Vaginal discharge
1.6
8.1
216
1395
Z30.2
ICD-10 Finland
Sterilization
1.2
8.0
919
7561
ZXC96
NOMESCO Finland
Robot assisted procedure
2.3
8.0
72
321
M54
ICD-10 Finland
Dorsalgia
1.3
8.0
735
5897
X91
ICPC
Condylomata acuminata female
3.2
7.9
39
122
R51.80
ICD-10 Finland
Headache
1.2
7.9
1084
9093
8140/3-C53.0
ICD-O-3
Adenocarcinoma, NOS, of endocervix
13.0
7.9
13
10
SPAT1153
SPAT
Removal of sutures
1.2
7.8
1561
13577
Z87.4
ICD-10 Finland
Personal history of diseases of the genitourinary system
2.1
7.8
85
409
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.3
7.8
651
5155
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.2
7.7
1400
12072
SPAT1254
SPAT
Administration of medicine
1.3
7.7
609
4790
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
2.4
7.7
63
267
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
7.4
7.7
17
23
Z09.9
ICD-10 Finland
Follow-up examination after unspecified treatment for other conditions
2.0
7.6
97
498
LDB10
NOMESCO Finland
Cryotherapy of cervix uteri
3.1
7.6
39
127
A03
ICPC
Fever
1.2
7.6
1183
10059
D11
ICPC
Diarrhoea
1.2
7.5
821
6721
N06AX16
ATC
venlafaxine; oral
1.2
7.4
1018
8539
M77.1
ICD-10 Finland
Lateral epicondylitis
1.3
7.4
500
3843
127
Kela drug reimbursment
Transplant complication
2.4
7.4
60
255
LCH13
NOMESCO Finland
Vacuum aspiration from uterus after medically induced abortion
1.6
7.4
177
1111
M54.4
ICD-10 Finland
Lumbago with sciatica
1.2
7.4
1002
8396
ZX095
NOMESCO Finland
Combined chemoradiotherapy
3.3
7.4
34
102
D07AD01
ATC
clobetasol; topical
1.2
7.4
831
6828
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.3
7.3
517
4001
1390
FHL
Colposcopy
4.3
7.3
25
58
T810, N872
ICD-10 Finland
NA
+∞
7.3
7
*
6230C
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE GRAVIS]
+∞
7.3
7
*
8111
FHL
Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)
4.5
7.2
24
54
D10
ICPC
Vomiting
1.3
7.2
467
3568
C53.10
ICD-10 Finland
Malignant tumor of the exocervix without histology
15.7
7.2
11
7
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
1.6
7.2
167
1041
LCD30
NOMESCO Finland
Radical hysterectomy
5.8
7.2
19
33
P17
ICPC
Tobacco abuse
2.0
7.1
89
454
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
20.0
7.1
10
5
JN3AD
NOMESCO Finland
Abdominal CT examination
1.4
7.1
293
2076
Z71.8
ICD-10 Finland
Other specified counselling
1.2
7.1
1668
14693
YX9VG
NOMESCO Finland
Other MRI eamination with high intensity magnet for dose design of radiotherapy
7.9
7.1
15
19
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.1
7.1
73
347
J01EA01
ATC
trimethoprim; systemic
1.2
7.0
1803
15991
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.2
7.0
1129
9618
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.3
7.0
469
3602
ULC02
NOMESCO Finland
Hysteroscopy
1.4
7.0
395
2957
R21
ICPC
Throat symptom/complaint
1.2
7.0
1673
14755
N30.0
ICD-10 Finland
Acute cystitis
1.2
7.0
891
7416
TAC99
NOMESCO Finland
Other blockade for chronic pain
2.9
6.9
40
139
N02AA05
ATC
oxycodone; systemic
1.3
6.9
445
3402
N72
ICD-10 Finland
Inflammatory disease of cervix uteri
2.1
6.9
71
336
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.2
6.8
1301
11255
LDC10
NOMESCO Finland
Partial excision of cervix uteri
8.2
6.8
14
17
SAA02
NOMESCO Finland
Basic examination of mouth
1.1
6.8
5057
48168
D01
ICPC
Abdominal pain/cramps general
1.3
6.8
685
5558
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
4.1
6.8
24
58
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.3
6.7
593
4730
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
6.7
1957
17514
LFC96
NOMESCO Finland
Other partial excision of vulva or perineum
16.7
6.7
10
6
N89.3
ICD-10 Finland
Dysplasia of vagina, unspecified
16.7
6.7
10
6
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.3
6.7
498
3882
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
0.8
6.7
861
10200
A11CC03
ATC
alfacalcidol; systemic
2.1
6.7
71
343
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.2
6.7
1050
8924
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.2
6.7
1803
16045
LFD00
NOMESCO Finland
Vulvectomy
22.5
6.7
9
*
M01AE02
ATC
naproxen; oral, rectal
1.1
6.7
4100
38568
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
0.8
6.7
411
5276
WX402
NOMESCO Finland
General anaesthesia
1.2
6.7
981
8290
L04AA01
ATC
[U] ciclosporin; systemic
2.1
6.6
74
362
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.2
6.6
966
8153
B02AA02
ATC
tranexamic acid; systemic
1.2
6.6
1258
10881
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
4.6
6.6
21
46
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
8.7
6.5
13
15
SPAT1249
SPAT
Treatment-related counselling outside office
1.1
6.5
2736
25107
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.2
6.5
694
5664
N03AX12
ATC
gabapentin; oral
1.2
6.5
795
6588
O04.1
ICD-10 Finland
Medical abortion, incomplete, complicated by delayed or excessive haemorrhage
1.9
6.5
93
504
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
2.7
6.5
42
157
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
2.8
6.5
38
135
X29
ICPC
Genital sympt/compl female other
1.8
6.4
111
636
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.2
6.4
893
7501
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.2
6.4
58
261
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
14.3
6.4
10
7
C53.09
ICD-10 Finland
Malignant tumor of endocervix, unspecified histology
14.3
6.4
10
7
SGC10
NOMESCO Finland
Covering pulpa of tooth
1.2
6.4
673
5488
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.2
6.4
668
5441
N97.2
ICD-10 Finland
Female infertility of uterine origin
3.9
6.4
24
62
8411
FHL
Local change laser, coagulation, biopsy or removal
3.6
6.4
26
72
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.2
6.3
1305
11362
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.2
6.3
58
263
J01FA10
ATC
azithromycin; systemic
1.1
6.3
4532
42967
KAY40
NOMESCO Finland
NA
0.6
6.3
73
1275
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
1.5
6.3
179
1175
4750B
ICD-9 Finland
Peritonsillar abscess[PERITONSILLITIS ABSCEDENS]
2.1
6.3
67
324
P01BA02
ATC
hydroxychloroquine; oral
1.3
6.3
471
3682
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
3.7
6.2
25
68
LWW96
NOMESCO Finland
Other reoperation in gynaecological surgery
3.7
6.2
25
68
SXA20
NOMESCO Finland
Local application of medicine to mouth
1.3
6.2
421
3243
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
26.7
6.2
8
*
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
26.7
6.2
8
*
N05CF02
ATC
zolpidem; oral
1.2
6.2
1110
9547
R05
ICPC
Cough
1.2
6.1
1378
12079
SDA05
NOMESCO Finland
Very demanding and lengthy parodonthologic therapy
1.4
6.1
268
1925
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.3
6.1
519
4121
A12AA04
ATC
calcium carbonate; oral
2.4
6.1
47
195
128
Kela drug reimbursment
Cancers of female genital organs
1.9
6.1
85
455
TKC20
NOMESCO Finland
Catheterisation of bladder
1.5
6.1
201
1368
R42
ICD-10 Finland
Dizziness and giddiness
1.2
6.0
1021
8737
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.1
6.0
4339
41085
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
1.6
6.0
153
981

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5117
32962
2.28
309.10
2.9
1.9
—
—
—
0
0
1661
1834
10.88
307.65
2.4
1.5
—
—
—
0
0
1061
5365
2.11
100.65
1.4
1.4
—
—
—
0
0
116
162
7.24
78.53
1.7
2.1
7.7
2.7
ug/l
0.59
76
92
1327
9922
1.40
25.46
1.3
1.2
—
—
—
0
0
5800
53153
1.26
22.51
4.3
4.0
—
—
—
0
0
5606
51303
1.25
21.41
4.2
3.9
2205.3
1917.6
e6/l
0.09
53
555
2761
23685
1.24
18.28
2.2
2.0
—
—
—
0
0
2741
23661
1.23
16.76
6.3
5.8
—
—
—
0
0
4286
38697
1.21
16.49
3.5
3.3
0.0
0.0
estimate
2.96
850
7583
6008
56042
1.22
16.33
4.1
3.8
9.9
10.0
mm/h
0.11
5656
52835
5749
53395
1.21
16.33
7.2
6.7
71.9
72.7
u/l
0.97
5421
50458
4253
38437
1.20
15.99
4.7
4.5
0.0
0.0
estimate
0.04
863
7686
8024
77430
1.34
15.81
11.7
10.4
18.9
18.5
mg/l
0.54
6226
59524
2910
25414
1.21
15.58
2.1
2.0
—
—
—
0
0
4132
37336
1.20
15.30
3.9
3.8
—
—
—
0
0
7724
74268
1.29
14.70
11.3
10.2
3.9
3.9
mmol/l
0.26
7495
72173
2055
17443
1.23
14.35
2.1
1.9
—
—
—
0
0
7696
74055
1.27
13.93
11.2
10.1
139.5
139.6
mmol/l
1.81
7484
72141
4204
38256
1.19
13.79
3.4
3.3
0.0
0.0
estimate
0.03
836
7449
4123
37513
1.18
13.40
6.1
5.6
0.0
0.0
e9/l
0.21
3659
33171
4099
37379
1.18
12.70
6.1
5.6
0.5
0.5
e9/l
0.46
3660
33140
2738
24128
1.19
12.67
3.5
3.2
55.2
76.8
e6/l
1.76
1783
15640
3854
35073
1.17
11.99
6.2
5.7
2.7
2.8
%
0.86
3614
32851
3870
35246
1.17
11.89
6.5
5.9
7.9
7.9
%
0.32
3654
33303
4238
38925
1.17
11.58
6.3
5.8
0.2
0.2
e9/l
0.00
3839
35064
1037
8332
1.28
11.53
2.2
2.2
4120.6
5958.2
u/l
1.30
407
3463
1990
17200
1.20
11.14
3.0
2.7
0.3
0.3
e6/l
0.08
1457
12545
3716
33850
1.17
11.13
6.4
5.7
0.7
0.7
%
0.42
3473
31719
4626
42863
1.16
11.07
8.6
8.4
4.0
3.9
e9/l
0.76
4111
37924
4222
38862
1.16
10.98
6.1
5.6
2.0
2.0
e9/l
0.08
3827
35150
1225
10093
1.25
10.97
2.6
2.4
1.0
1.2
e6/l
0.94
668
5405
3955
36235
1.16
10.91
6.0
5.5
56.6
56.5
%
0.22
3722
34213
3750
34255
1.16
10.68
5.5
5.3
9.2
9.6
umol/l
2.16
3519
32272
8265
80648
1.31
10.66
9.4
8.6
23.7
23.9
u/l
0.21
8033
78468
2992
26871
1.17
10.58
5.2
4.7
1.2
1.2
mmol/l
0.82
2705
24594
3326
30145
1.16
10.41
6.0
5.4
1.2
1.2
mmol/l
1.32
2816
25547
3993
36702
1.16
10.35
6.3
5.6
29.6
29.7
%
0.46
3750
34552
451
3282
1.39
9.95
4.0
2.5
—
—
—
0
0
2430
21552
1.17
9.91
2.6
2.5
—
—
—
0
0
2969
26771
1.16
9.78
4.6
4.2
36.6
36.7
g/l
0.07
2793
24982
1980
17305
1.18
9.58
2.9
2.6
—
—
—
0
0
2150
18926
1.18
9.55
3.0
2.8
36.5
72.9
e6/l
1.80
1600
14055
1978
17291
1.18
9.54
3.4
3.3
—
—
—
0
0
1906
16620
1.19
9.46
3.7
3.3
98.1
98.3
%
0.17
1849
16100
1126
9427
1.22
8.58
2.7
2.5
4.7
5.0
e6/l
0.30
571
4767
811
6577
1.26
8.29
2.3
2.8
45.9
38.2
u/ml
0.19
785
6352
2263
20193
1.16
8.27
3.8
3.6
0.0
0.0
estimate
0.01
865
7604
8368
82063
1.29
8.24
10.8
9.8
—
—
—
0
0
5763
54827
1.14
8.12
3.0
2.7
36.0
34.1
u/l
1.17
5502
52424
2761
25029
1.15
8.08
1.8
1.8
99.7
99.6
pmol/l
0.06
1494
13214
291
2043
1.44
7.94
3.4
2.4
—
—
—
0
0
7624
74127
1.19
7.70
5.1
5.1
1.7
2.0
mu/l
3.92
7197
70468
554
4327
1.30
7.68
2.8
1.9
—
—
—
0
0
1426
12351
1.18
7.49
1.7
1.6
—
—
—
0
0
84
438
1.93
7.43
1.1
1.1
—
—
—
0
0
2358
21283
1.15
7.18
2.5
2.4
53.3
56.7
u/l
4.39
2184
19781
593
4723
1.27
7.07
2.7
1.8
—
—
—
0
0
597
4763
1.27
7.02
2.7
1.8
—
—
—
0
0
3570
33143
1.13
6.96
8.6
8.0
0.0
0.0
e9/l
2.54
2959
27230
1781
15795
1.16
6.90
1.3
1.3
10.9
9.2
u/ml
0.50
677
6795
594
4747
1.27
6.90
2.3
1.8
—
—
—
0
0
468
3629
1.31
6.88
3.0
1.9
—
—
—
0
0
4069
38167
1.12
6.51
4.1
3.8
6.3
6.3
mmol/l
0.72
3678
34394
8778
86898
1.45
6.33
17.4
15.7
269.3
269.0
e9/l
0.17
8627
85368
6837
66173
1.14
6.29
4.5
4.4
14.3
14.3
pmol/l
0.28
6409
62361
2298
20864
1.14
6.27
5.7
5.4
1.1
1.1
inr
0.06
734
6927
1374
12030
1.17
6.26
2.8
2.5
516.3
521.0
mosm/kgh2o
0.32
1168
10184
8783
86964
1.45
6.24
17.3
15.6
30.2
30.0
pg
32.08
8703
86235
1920
17232
1.15
6.23
1.9
2.0
171.4
141.3
u/l
0.57
1823
16332
8783
86966
1.45
6.22
17.3
15.7
90.8
90.2
fl
29.43
8701
86240
8783
86976
1.44
6.11
17.4
15.7
4.4
4.5
e12/l
14.29
8622
85346
8784
86996
1.44
6.02
17.4
15.8
6.8
6.7
e9/l
5.01
8625
85313
978
8359
1.19
5.95
1.7
1.6
—
—
—
0
0
578
4695
1.25
5.87
2.6
1.8
—
—
—
0
0
8784
87010
1.43
5.86
17.5
15.8
132.9
132.9
g/l
0.12
8704
86275
1490
13213
1.15
5.70
2.5
2.3
9.0
8.5
e6/l
0.38
1281
11431
2018
18268
1.13
5.69
6.4
6.3
—
—
—
0
0
1995
18056
1.13
5.64
4.0
3.5
7.4
7.4
ph
0.43
376
3451
463
3691
1.27
5.54
8.8
7.4
—
—
—
0
0
674
5606
1.22
5.49
3.3
3.5
—
—
—
0
0
434
3441
1.27
5.44
1.6
1.7
—
—
—
0
0
1821
16443
1.13
5.30
1.3
1.3
43.0
29.8
iu/ml
0.34
561
5148
1426
12672
1.15
5.27
1.4
1.4
577.7
567.4
titre
0.07
301
2580
1002
8680
1.17
5.20
1.9
1.8
—
—
—
0
0
4846
46225
1.11
5.14
2.9
2.8
—
—
—
0
0
264
1974
1.35
5.10
2.2
1.9
1.5
1.4
g/l
0.92
225
1716
627
5238
1.21
4.91
2.4
2.2
0.2
0.2
g/l
1.54
587
4959
592
4919
1.22
4.89
6.6
6.4
13.2
13.7
kpa
1.22
563
4695
592
4921
1.22
4.88
6.6
6.4
5.0
5.0
kpa
0.14
565
4703
1050
9183
1.16
4.83
3.2
3.0
0.8
0.8
mmol/l
1.57
989
8592
2406
22196
1.11
4.81
3.1
3.1
2.3
2.3
mmol/l
0.34
2151
19947
1796
16299
1.13
4.78
3.6
3.5
1.0
1.0
kg/l
0.18
260
2503
99
622
1.60
4.74
1.3
1.3
18.6
60.3
u/ml
—
6
34
524
4322
1.23
4.67
1.4
1.3
—
—
—
0
0
491
4026
1.23
4.63
7.3
7.1
119.8
120.6
g/l
0.39
478
3868
513
4226
1.23
4.63
6.9
6.9
96.2
96.3
%
0.18
494
4051
176
1253
1.41
4.62
1.3
1.5
—
—
—
0
0
589
4933
1.21
4.51
6.6
6.4
0.7
0.9
mmol/l
0.27
442
3752
625
5265
1.20
4.50
1.3
1.2
—
—
—
0
0
43
214
2.01
4.49
2.7
2.8
—
—
—
0
0
2260
20850
1.11
4.47
2.7
2.6
28.0
66.9
ng/l
0.57
974
9166
675
5731
1.19
4.46
7.0
6.1
104.7
104.9
mmol/l
0.49
663
5627
75
448
1.68
4.40
4.8
2.1
—
—
—
0
0
2335
21610
1.11
4.33
1.3
1.3
1.7
1.5
u/ml
0.32
681
6452
1967
18044
1.12
4.30
1.4
1.4
2.1
2.1
g/l
0.01
1191
11580
1350
12113
1.13
4.29
2.4
2.4
114.6
98.8
ug/g
0.83
1018
9469
7218
70541
1.12
4.22
3.6
3.6
5.6
5.6
mmol/l
0.54
6748
66332
1478
13351
1.13
4.22
1.5
1.5
21.3
21.2
nmol/l
0.10
1294
11803
895
7824
1.16
4.15
3.1
2.4
6.0
6.1
umol/l
0.08
739
6552
1489
13470
1.13
4.14
4.1
3.7
—
—
—
0
0
106
700
1.52
4.13
1.6
1.4
54.9
66.0
mmol/l
1.97
91
552
80
497
1.62
4.07
1.6
1.6
1.5
1.2
promille
0.87
60
373
1084
9634
1.14
3.99
1.7
1.7
1155.8
1199.1
nmol/l
0.89
860
7599
1914
17607
1.11
3.94
1.7
1.7
—
—
—
0
0
197
1473
1.34
3.90
3.5
2.9
1.4
1.3
mg/l
1.02
189
1385
882
7746
1.15
3.85
1.4
1.3
—
—
—
0
0
2347
21882
1.10
3.67
1.7
1.7
—
—
—
0
0
114
786
1.46
3.65
2.9
2.6
1.5
1.4
%
0.10
84
620
276
2188
1.27
3.59
9.4
8.2
24.1
24.2
mmol/l
0.12
253
2061
1041
9301
1.13
3.54
1.3
1.3
25.3
26.3
iu/l
0.44
911
8155
92
612
1.51
3.53
2.2
2.0
46.3
45.4
%
0.10
13
101
1126
10121
1.13
3.48
2.9
2.9
217.9
300.0
ng/l
0.74
598
5434
288
2309
1.26
3.42
7.9
8.2
—
—
—
0
0
44
244
1.81
3.42
25.9
25.1
104.2
112.1
ug/l
0.43
38
196
329
2678
1.24
3.42
3.6
4.5
—
—
—
0
0
1194
10788
1.12
3.39
2.5
2.5
2.4
2.4
mmol/l
0.13
1039
9392
2685
25278
1.09
3.33
3.4
3.0
29.8
29.8
u/l
0.00
2550
24203
660
5739
1.16
3.33
2.6
2.3
4.3
4.1
e9/l
1.13
530
4852
1805
16707
1.10
3.25
3.5
3.1
7.2
7.4
mmol/l
0.70
1544
14414
446
3763
1.19
3.24
9.5
6.9
7.9
7.3
mmol/l
1.15
424
3622
45
256
1.76
3.24
1.6
1.3
34.9
34.1
mmol/l
0.07
40
220
562
4838
1.17
3.23
3.5
3.3
—
—
—
0
0
73
472
1.55
3.22
3.3
2.6
57.9
56.8
%
0.16
48
303
640
5569
1.16
3.21
2.7
2.5
10.5
10.4
g/l
0.19
584
5112
1685
15580
1.10
3.09
2.9
2.9
—
—
—
0
0
2792
26402
1.08
3.07
1.7
1.7
—
—
—
0
0
916
8197
1.13
3.06
2.0
2.1
29.2
29.1
s
0.10
891
7924
467
3980
1.18
3.05
4.3
3.5
5.8
5.8
kpa
0.10
454
3845
7
12
5.84
3.02
1.0
1.0
—
—
—
0
0
3425
32682
1.08
2.96
2.3
2.3
76.0
2756.5
nmol/l
0.50
3158
30583
462
3951
1.18
2.91
4.3
3.6
2.0
1.8
mmol/l
0.24
372
3213
298
2448
1.22
2.90
1.4
1.3
13.4
6.9
u/ml
0.65
46
252
7565
74452
1.10
2.85
12.3
11.2
39.5
39.5
%
0.32
6178
60887
342
2854
1.21
2.84
2.6
1.9
1.1
1.2
g/l
1.18
324
2730
330
2746
1.21
2.83
1.3
1.3
31.3
35.4
u/ml
0.17
26
196
51
314
1.63
2.80
2.2
2.3
145.9
174.8
umol/l
0.31
33
158
301
2485
1.22
2.80
1.4
1.3
6.1
8.2
u/ml
0.54
63
407
6512
63692
1.08
2.80
4.2
4.3
37.1
37.5
mmol/mol
5.10
6122
60329
14
53
2.64
2.79
9.1
11.0
4.6
5.0
mmol/l
0.29
14
53
332
2770
1.21
2.77
2.7
2.0
0.2
0.2
g/l
0.47
312
2642
72
482
1.50
2.76
2.7
2.7
817.5
891.2
e6/l
0.34
31
216
465
4001
1.17
2.74
7.5
6.1
1.3
1.2
mmol/l
0.10
446
3866
999
9052
1.12
2.72
2.5
2.2
2.4
2.5
g/l
2.54
897
8402
843
7567
1.13
2.70
1.2
1.2
—
—
—
0
0
120
888
1.36
2.67
3.3
2.9
31.0
33.1
umol/l
0.68
108
768
53
334
1.59
2.67
2.6
2.5
166.2
162.3
au/ml
—
5
54
902
8136
1.12
2.66
1.5
1.4
—
—
—
0
0
884
7965
1.12
2.66
1.5
1.5
—
—
—
0
0
367
3108
1.19
2.62
1.4
1.5
86.7
100.8
pmol/l
0.40
362
3034
493
4278
1.16
2.62
1.6
1.8
1.3
1.3
g/l
0.38
451
3967
376
3198
1.18
2.57
3.6
3.0
4.7
4.7
kpa
0.03
364
3078
1907
17873
1.09
2.56
2.2
2.1
2.7
2.7
mg/l
0.17
1628
15468
229
1857
1.24
2.56
1.4
1.6
—
—
—
0
0
261
2148
1.22
2.54
5.6
4.1
24.2
24.3
mmol/l
0.13
231
1912
6876
67481
1.08
2.52
13.8
12.6
13.5
13.5
%
0.95
6752
66240
81
568
1.43
2.49
2.1
2.3
—
—
—
0
0
140
1074
1.31
2.47
2.8
2.7
24.7
24.3
mmol/l
0.63
119
945
1894
17793
1.08
2.39
1.7
1.7
1.0
0.9
mg/l
0.78
1407
13278
1220
11262
1.10
2.32
2.6
2.5
701.1
681.1
ng/l
0.10
992
9164
607
5397
1.13
2.31
13.9
13.8
1.2
1.1
inr
0.39
108
888
624
5562
1.13
2.28
1.3
1.3
24.3
37.8
au/ml
1.89
16
227
44
277
1.59
2.27
2.1
2.0
—
—
—
0
0
316
2681
1.19
2.26
5.1
6.3
24.2
24.4
mmol/l
0.44
297
2484
54
357
1.52
2.26
3.1
3.0
9.4
7.8
mg/l
0.55
42
272
53
349
1.52
2.26
1.8
1.9
—
—
—
0
0
672
6023
1.13
2.25
2.3
2.3
17.9
22.8
au/ml
0.90
43
482
241
1996
1.21
2.24
2.4
2.1
10.6
10.2
mg/l
0.32
228
1882
769
6948
1.12
2.24
3.9
3.4
—
—
—
0
0
128
985
1.30
2.24
1.0
1.1
—
—
—
0
0
332
2832
1.18
2.23
1.4
1.4
21.6
25.0
u/l
1.25
251
2344
369
3176
1.17
2.23
1.9
2.0
6.4
5.5
ug/l
0.16
321
2761
520
4592
1.14
2.21
1.4
1.4
—
—
—
0
0
140
1095
1.28
2.17
1.9
2.0
—
—
—
0
0
52
347
1.50
2.10
2.2
2.8
39.2
45.7
%
0.66
14
130
742
6717
1.11
2.10
6.7
4.8
1.0
1.0
mmol/l
0.36
698
6287
32
522
0.61
2.09
1.2
1.5
—
—
—
0
0
200
1639
1.23
2.09
2.1
2.0
3.7
3.7
g/l
0.20
150
1182
160
1281
1.25
2.07
1.7
1.8
38.2
38.8
g/l
0.65
139
1128
131
1024
1.28
2.06
4.0
6.4
11.2
11.0
mmol/l
0.22
119
918
402
3506
1.15
2.06
2.3
2.5
70.9
72.1
e9/l
0.23
306
2552
298
2539
1.18
2.06
1.6
1.6
9.3
9.9
u/ml
—
6
69
577
5155
1.13
2.06
4.0
3.8
0.8
0.6
%
0.28
123
910
131
1025
1.28
2.05
4.0
6.4
106.1
105.6
mmol/l
0.81
119
919
70
498
1.41
2.05
6.4
6.7
12.0
11.3
mg/l
0.45
65
470
121
940
1.29
2.01
3.1
2.3
8.8
8.7
kpa
0.14
108
877
331
2853
1.17
2.00
2.0
2.0
—
—
—
0
0
4450
43217
1.06
2.00
2.9
3.0
75.2
68.8
ug/l
1.83
4188
41150
1093
10114
1.09
1.99
2.5
2.2
14.7
14.3
umol/l
0.80
993
9400
359
3116
1.16
1.98
1.3
1.2
—
—
—
0
0
48
320
1.50
1.97
1.1
1.1
3.5
2.2
u/ml
0.26
30
172
120
934
1.29
1.97
4.7
3.6
—
—
—
0
0
34
209
1.63
1.97
1.7
1.6
—
—
—
0
0
621
5597
1.12
1.93
4.2
4.0
0.8
0.9
%
0.30
167
1220
882
8096
1.10
1.92
2.7
2.3
24.3
23.6
%
0.67
751
7002
184
1510
1.22
1.92
2.0
2.0
10.3
10.1
g/l
0.21
155
1297
58
406
1.43
1.88
2.8
3.2
0.8
0.8
nmol/l
0.34
39
297
59
415
1.42
1.87
2.9
2.6
0.1
0.3
e9/l
1.17
59
409
2347
22403
1.06
1.86
3.1
2.8
—
—
—
0
0
9
34
2.65
1.86
1.2
1.3
—
—
—
0
0
164
1338
1.23
1.83
4.3
2.8
7.4
7.4
ph
0.28
130
1115
7532
74408
1.08
1.81
3.8
3.8
2.9
2.9
mmol/l
1.15
7114
70414
194
1613
1.21
1.80
3.7
5.0
1.2
1.2
mmol/l
0.36
177
1415
132
1054
1.26
1.79
2.2
1.7
31.4
34.8
iu/ml
0.12
11
59
136
1090
1.25
1.79
2.7
3.1
35.4
40.1
mg/l
0.35
113
881
191
1587
1.21
1.79
1.3
1.5
6.2
12.2
iu/ml
—
5
39
34
215
1.58
1.78
3.4
4.3
5060.8
2474.3
mg/l
0.21
26
154
203
1699
1.20
1.77
3.7
4.2
—
—
—
0
0
566
5115
1.11
1.70
2.3
2.5
1.8
1.7
%
0.23
499
4567
135
1089
1.24
1.70
2.7
3.1
28.2
37.7
mg/l
0.83
112
881
141
1144
1.24
1.68
2.5
2.0
131.2
129.9
g/l
0.26
101
847
593
5380
1.11
1.67
4.3
4.1
0.1
0.2
%
1.54
158
1140
120
960
1.25
1.63
1.6
1.6
—
—
—
0
0
218
1853
1.18
1.62
1.3
1.4
340.6
310.2
ug/g
1.08
123
952
36
238
1.51
1.59
1.1
1.4
—
—
—
0
0
69
515
1.34
1.58
3.9
2.9
—
—
—
0
0
1099
11738
0.93
1.58
1.3
1.3
—
—
—
0
0
818
7567
1.09
1.55
1.3
1.4
—
—
—
0
0
76
578
1.32
1.54
2.8
2.8
—
—
—
0
0
286
2495
1.15
1.54
1.2
1.1
—
—
—
0
0
698
6413
1.10
1.54
2.5
2.3
33.5
36.2
u/l
0.49
583
5467
5
15
3.33
1.52
1.0
1.3
—
—
—
0
0
26
161
1.62
1.52
2.9
2.2
—
—
—
0
0
16
86
1.86
1.50
5.6
5.1
49.1
33.0
ug/min
—
10
53
83
643
1.29
1.49
1.2
1.2
—
—
—
0
0
129
1054
1.23
1.48
1.5
1.4
—
—
—
0
0
27
171
1.58
1.45
4.5
4.8
—
—
—
0
0
567
5177
1.10
1.44
4.2
4.1
0.1
0.2
%
0.24
128
981
7137
70512
1.06
1.44
3.2
3.2
1.2
1.2
mmol/l
1.18
6747
66885
128
1050
1.22
1.43
2.8
3.1
1.4
1.4
ratio
—
7
114
362
3229
1.13
1.42
2.3
2.5
150.6
120.3
ng/l
0.70
319
2891
2001
19164
1.06
1.41
4.2
3.9
—
—
—
0
0
207
1778
1.17
1.40
4.0
4.6
1.9
1.7
%
1.15
195
1657
10
46
2.18
1.39
1.0
1.6
—
—
—
0
0
247
2828
0.87
1.39
1.2
1.2
—
—
—
0
0
536
4896
1.10
1.37
1.4
1.3
206.8
237.8
miu/ml
1.47
266
2519
18
104
1.73
1.36
1.0
1.4
—
151.2
—
0
15
222
1922
1.16
1.36
1.2
1.2
—
—
—
0
0
1696
16183
1.06
1.36
2.3
2.1
2193.2
2778.1
umol/l
0.43
1516
14441
226
1961
1.16
1.35
3.5
3.0
0.6
0.7
%
1.56
214
1874
231
2008
1.15
1.35
3.6
3.1
1.6
1.3
%
1.71
231
1991
36
248
1.45
1.34
1.2
1.3
—
—
—
0
0
310
2751
1.13
1.34
3.7
2.8
5.2
5.1
kpa
1.92
284
2569
7446
73706
1.06
1.31
3.6
3.5
4.8
4.9
mmol/l
0.73
7086
70217
204
1762
1.16
1.30
4.0
4.7
0.9
0.9
%
1.37
192
1646
444
4029
1.11
1.30
1.3
1.3
1.3
1.1
u/ml
0.12
32
336
180
1543
1.17
1.27
1.3
1.3
—
—
—
0
0
190
1637
1.16
1.26
3.0
3.3
152.4
340.5
u/ml
0.84
161
1397
114
939
1.22
1.26
5.2
5.4
369.0
375.4
umol/l
0.18
108
798
1035
9751
1.07
1.26
1.2
1.2
—
—
—
0
0
47
345
1.36
1.25
2.5
2.6
—
—
—
0
0
7407
73338
1.06
1.23
3.5
3.5
1.6
1.6
mmol/l
0.07
7033
69747
520
4774
1.09
1.22
2.7
2.7
—
—
—
0
0
5
19
2.63
1.21
1.0
1.2
160.0
247.0
nmol/l
—
5
19
111
916
1.21
1.21
1.1
1.1
1.5
1.5
g/l
0.10
100
836
402
3650
1.11
1.19
2.3
2.3
66.8
67.2
g/l
0.55
363
3364
32
453
0.71
1.18
1.1
1.3
—
—
—
0
0
51
384
1.33
1.17
2.7
2.5
—
—
—
0
0
214
1873
1.15
1.17
2.7
2.6
—
—
—
0
0
25
165
1.52
1.17
1.7
1.6
—
—
—
0
0
36
256
1.41
1.17
1.5
1.7
191.3
141.0
au/ml
—
5
33
43
316
1.36
1.16
2.2
1.8
62.1
22.3
ug/l
0.65
43
310
119
995
1.20
1.15
2.9
2.1
16.9
16.7
%
0.27
62
478
303
2716
1.12
1.15
3.8
2.8
7.4
7.4
ph
0.31
50
358
1506
14405
1.05
1.12
4.1
3.9
12.4
9.7
mg/mmol
0.73
929
8865
11
58
1.90
1.12
14.5
5.4
—
—
—
0
0
15
88
1.71
1.11
2.6
2.5
—
—
—
0
0
47
355
1.33
1.08
3.2
3.2
—
—
—
0
0
89
730
1.22
1.06
1.1
1.1
—
—
—
0
0
133
1133
1.18
1.06
4.8
2.9
2.1
2.3
mmol/l
0.18
77
707
92
758
1.22
1.05
3.3
2.3
—
—
—
0
0
7
33
2.12
1.05
1.6
1.3
320.3
562.7
nmol/l
—
7
33
257
2297
1.12
1.05
1.1
1.1
—
—
—
0
0
5
22
2.27
1.03
3.4
2.2
—
—
—
0
0
76
616
1.24
1.02
1.9
2.1
11.8
13.1
%
0.33
30
335
21
138
1.52
1.02
1.0
1.1
—
—
—
0
0
190
1671
1.14
1.01
2.0
1.9
—
—
—
0
0
5
108
0.46
1.00
1.4
1.1
—
—
—
0
0
9
49
1.84
0.98
1.0
1.7
—
—
—
0
0
91
756
1.21
0.98
2.5
2.4
1.4
1.3
e9/l
0.32
52
448
31
223
1.39
0.98
3.2
2.9
103.5
98.9
ng/l
0.03
15
114
67
540
1.24
0.96
1.6
1.4
—
—
—
0
0
520
4834
1.08
0.96
3.5
3.1
1.2
1.2
mmol/l
1.15
451
4244
1370
13141
1.05
0.94
1.5
1.4
—
—
—
0
0
195
1729
1.13
0.93
1.4
1.3
—
—
—
0
0
3050
31244
0.96
0.93
2.2
2.2
—
—
—
0
0
151
1317
1.15
0.92
1.5
1.4
—
—
—
0
0
14
86
1.63
0.90
2.8
2.1
—
—
—
0
0
6
29
2.07
0.89
1.0
1.1
—
—
—
0
0
243
2191
1.11
0.89
1.3
1.3
—
—
—
0
0
43
332
1.30
0.89
1.8
1.9
8.4
9.5
mg/l
0.75
34
271
181
1605
1.13
0.88
1.4
1.3
143.0
109.1
u/ml
0.69
41
384
164
1445
1.14
0.88
2.3
2.1
359.6
474.2
ug/l
0.26
151
1279
123
1421
0.86
0.88
1.1
1.1
115.2
119.7
%
0.84
112
1304
8
43
1.86
0.87
1.4
1.6
322.3
308.5
umol/24h
—
8
43
6
30
2.00
0.87
1.0
1.1
—
—
—
0
0
114
1322
0.86
0.86
1.4
1.5
0.5
0.6
g/l
1.27
83
1003
556
5210
1.07
0.86
3.3
3.6
5.9
26.3
ug/l
1.73
412
3774
121
1396
0.86
0.85
3.7
3.3
28.9
22.2
mg/l
0.68
59
844
13
204
0.64
0.85
1.0
1.1
—
1.8
—
0
40
29
213
1.36
0.84
1.0
1.1
—
—
—
0
0
212
1906
1.11
0.83
1.1
1.1
—
—
—
0
0
58
470
1.24
0.83
1.4
1.5
27678.9
56040.5
e6/l
0.42
38
327
145
1274
1.14
0.83
2.9
3.8
3.8
3.8
mmol/l
0.06
138
1196
8
46
1.74
0.82
5.3
3.6
—
—
—
0
0
16
105
1.52
0.81
1.1
1.2
—
—
—
0
0
93
1088
0.85
0.80
1.4
1.5
10.4
10.9
mmol/l
0.26
12
138
70
581
1.21
0.80
3.9
4.1
6.0
7.2
mmol/l
2.73
60
475
47
374
1.26
0.79
2.3
2.4
10.3
10.9
%
0.48
47
374
6
33
1.82
0.79
1.2
1.1
—
—
—
0
0
45
564
0.80
0.79
17.2
16.9
1508.9
4477.2
nmol/l
0.79
45
541
211
1904
1.11
0.79
1.1
1.1
—
—
—
0
0
61
502
1.22
0.77
1.4
1.5
24.5
26.4
umol/l
0.21
56
481
140
1235
1.14
0.77
1.4
1.3
41.5
56.9
u/ml
—
10
84
78
658
1.19
0.76
1.8
1.6
46.4
50.2
%
0.37
49
402
293
2693
1.09
0.76
2.4
2.1
45.5
9.9
iu/l
0.41
133
1137
27
200
1.35
0.76
1.0
1.1
—
—
—
0
0
27
200
1.35
0.76
1.0
1.1
—
—
—
0
0
27
200
1.35
0.76
1.0
1.1
—
—
—
0
0
16
107
1.50
0.76
1.0
1.3
—
—
—
0
0
191
1720
1.11
0.75
1.3
1.3
20.1
20.6
u/ml
—
6
37
284
3086
0.92
0.74
2.3
2.2
—
—
—
0
0
184
1656
1.11
0.74
1.3
1.2
282.9
269.7
u/ml
0.28
129
1110
151
1344
1.13
0.73
2.5
2.6
—
—
—
0
0
38
298
1.28
0.73
1.3
1.2
6.1
6.1
mmol/l
0.01
33
278
139
1231
1.13
0.73
1.8
1.7
7363.7
8126.6
e6/l
0.21
106
909
1427
13792
1.04
0.73
3.4
3.2
382.7
489.7
mg/l
0.39
885
8274
449
4209
1.07
0.72
3.9
3.3
85.3
75.8
ng/l
1.25
409
3718
907
8684
1.05
0.71
1.2
1.2
171.3
153.4
iu/ml
0.51
354
3480
5
26
1.92
0.70
1.2
1.2
—
—
—
0
0
229
2091
1.10
0.70
1.3
1.3
111.8
156.8
titre
0.31
22
194
94
814
1.16
0.69
2.8
3.3
—
—
—
0
0
680
6469
1.06
0.69
1.2
1.3
254.1
179.4
u/ml
0.68
630
5984
316
2931
1.08
0.68
3.1
2.8
—
—
—
0
0
11
69
1.59
0.68
1.0
1.1
1.5
1.6
umol/24h
0.10
11
69
101
882
1.15
0.67
1.2
1.4
—
—
—
0
0
215
1964
1.10
0.66
3.4
2.8
0.2
0.3
g/l
2.23
81
756
612
5812
1.06
0.66
1.2
1.2
—
—
—
0
0
159
1765
0.90
0.66
1.6
1.6
7.7
7.6
mmol/l
0.19
103
1094
44
539
0.82
0.66
13.4
12.2
870.3
842.9
nmol/l
0.17
44
519
7
44
1.59
0.65
1.1
1.0
—
—
—
0
0
7
44
1.59
0.65
1.0
1.2
—
—
—
0
0
11
70
1.57
0.65
1.0
1.1
0.1
0.6
u/ml
—
5
27
5
29
1.72
0.64
1.0
1.0
—
—
—
0
0
505
5330
0.94
0.62
1.4
1.5
—
—
—
0
0
71
609
1.17
0.61
1.2
1.2
—
—
—
0
0
738
7708
0.95
0.61
1.6
1.7
—
—
—
0
0
720
6889
1.05
0.60
3.4
3.4
4.6
4.5
pmol/l
0.71
644
6238
1804
17580
1.03
0.60
1.6
1.6
1.4
1.3
mmol/l
0.53
1555
15330
77
888
0.87
0.60
1.4
1.4
0.4
0.4
g/l
0.02
53
629
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
0.1
—
0
15
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
505
5323
0.95
0.60
1.4
1.4
—
—
—
0
0
77
887
0.87
0.60
1.4
1.4
2.8
3.0
g/l
0.92
52
623
77
887
0.87
0.60
1.4
1.4
6.9
6.6
g/l
0.24
52
627
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
135
1499
0.90
0.59
1.2
1.2
—
—
—
0
0
139
1253
1.11
0.58
1.1
1.1
—
—
—
0
0
17
123
1.38
0.57
1.5
1.4
—
—
—
0
0
80
698
1.15
0.57
1.9
1.7
—
—
—
0
0
38
310
1.23
0.56
1.0
1.1
—
—
—
0
0
590
5631
1.05
0.56
1.5
1.6
281.9
314.5
mu/l
1.35
529
5000
240
2226
1.08
0.56
1.3
1.3
48.8
38.3
u/ml
0.52
34
234
108
963
1.12
0.55
1.6
1.4
—
—
—
0
0
38
461
0.82
0.55
1.1
1.1
—
—
—
0
0
153
1679
0.91
0.55
1.1
1.1
11.4
10.3
au/ml
0.08
12
124
521
5468
0.95
0.54
1.5
1.5
—
—
—
0
0
151
1376
1.10
0.53
3.2
2.3
—
—
—
0
0
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
139
1528
0.91
0.52
1.3
1.2
2.8
4.1
u/ml
1.42
67
620
71
619
1.15
0.52
1.1
1.1
—
—
—
0
0
28
223
1.26
0.52
1.1
1.2
—
—
—
0
0
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
17
126
1.35
0.51
1.1
1.3
—
—
—
0
0
65
564
1.15
0.51
1.6
1.7
279.6
281.9
mosm/kgh2o
0.36
50
453
20
259
0.77
0.51
1.0
1.1
5.1
5.1
mg/g
0.02
20
242
15
109
1.38
0.50
1.8
2.0
—
—
—
0
0
9
65
1.38
0.50
1.1
1.0
—
—
—
0
0
171
1573
1.09
0.50
1.2
1.2
—
—
—
0
0
86
763
1.13
0.50
1.2
1.2
—
—
—
0
0
32
390
0.82
0.50
1.3
1.5
123.1
130.5
nmol/l
0.50
32
390
144
1316
1.10
0.49
1.2
1.1
—
—
—
0
0
92
1029
0.89
0.49
3.9
4.4
101.9
105.7
u/ml
0.02
38
330
18
136
1.32
0.49
1.1
1.2
—
—
—
0
0
795
7674
1.04
0.48
2.0
2.0
383.3
376.2
nmol/l
0.47
732
7083
7
46
1.52
0.48
1.0
1.1
—
—
—
0
0
13
93
1.40
0.48
1.0
1.0
0.1
0.2
u/ml
—
5
36
25
199
1.26
0.47
6.7
2.2
10.6
9.1
mmol/l
0.74
18
153
10
143
0.70
0.47
1.2
1.2
—
—
—
0
0
63
720
0.87
0.47
1.1
1.2
0.1
1.0
u/ml
1.88
22
278
51
592
0.86
0.47
5.9
6.6
—
—
—
0
0
14
102
1.37
0.47
1.2
1.6
108.3
58.4
ng/l
—
8
54
1234
12675
0.97
0.47
2.0
2.0
—
—
—
0
0
12
85
1.41
0.46
1.7
1.9
—
—
—
0
0
19
147
1.29
0.45
1.8
1.8
—
—
—
0
0
349
3312
1.06
0.45
1.2
1.2
10.7
12.1
u/l
1.37
291
2769
316
2992
1.06
0.44
2.4
2.4
0.2
0.2
e6/l
0.09
302
2856
7
51
1.37
0.44
1.0
1.2
—
—
—
0
0
158
1461
1.08
0.43
1.1
1.1
—
—
—
0
0
13
95
1.37
0.43
1.2
1.2
—
—
—
0
0
121
1106
1.10
0.43
4.6
2.7
—
—
—
0
0
19
241
0.79
0.43
1.1
1.2
—
—
—
0
0
11
151
0.73
0.42
1.4
1.6
—
—
—
0
0
8
57
1.40
0.42
1.0
1.6
—
—
—
0
0
81
727
1.12
0.41
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
80
889
0.90
0.40
1.4
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
0.2
—
0
9
85
767
1.11
0.40
1.0
1.1
0.4
1.3
u/ml
0.91
19
200
158
1468
1.08
0.40
1.0
1.0
0.2
0.3
u/ml
0.09
22
297
20
159
1.26
0.40
1.1
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
2.0
—
—
—
0
0
82
739
1.11
0.39
1.8
2.0
3.5
1588.7
u/ml
0.59
72
638
23
281
0.82
0.39
1.7
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
46
400
1.15
0.38
1.5
1.5
1713.6
2151.9
ml
—
5
72
458
4399
1.04
0.38
1.1
1.1
—
—
—
0
0
9
67
1.34
0.38
2.8
2.1
—
—
—
0
0
47
536
0.88
0.37
1.0
1.1
1576.6
1490.8
miu/ml
0.19
47
536
8
114
0.70
0.37
1.0
1.4
—
—
—
0
0
768
7907
0.97
0.37
1.5
1.4
—
—
—
0
0
92
1007
0.91
0.36
2.9
2.6
53.4
78.5
ug/min
0.55
60
638
29
343
0.84
0.36
1.6
1.7
—
—
—
0
0
28
235
1.19
0.36
2.3
3.0
7.4
7.4
ph
0.37
14
54
12
90
1.33
0.35
1.0
1.1
—
—
—
0
0
31
263
1.18
0.35
1.0
1.1
—
—
—
0
0
20
162
1.24
0.35
2.0
2.4
—
—
—
0
0
16
126
1.27
0.35
1.1
1.1
—
—
—
0
0
667
6470
1.03
0.35
1.4
1.4
—
—
—
0
0
6
43
1.40
0.35
1.0
1.0
—
—
—
0
0
63
565
1.12
0.35
2.8
2.5
0.2
0.2
e9/l
0.31
56
469
24
199
1.21
0.35
2.7
2.1
—
—
—
0
0
182
1712
1.06
0.34
4.1
2.8
24.8
24.7
mmol/l
0.24
174
1592
34
292
1.17
0.34
1.5
1.9
—
—
—
0
0
6
44
1.36
0.34
1.7
1.4
—
—
—
0
0
53
471
1.13
0.34
1.3
1.3
—
—
—
0
0
39
447
0.87
0.34
1.9
2.0
—
—
—
0
0
1367
13408
1.02
0.33
1.6
1.6
28041858.2
29601803.8
pmol/l
0.04
1159
11665
6932
69624
0.98
0.33
14.5
13.2
332.1
331.7
g/l
3.51
6884
69149
58
520
1.12
0.33
2.3
2.4
—
—
—
0
0
521
5040
1.04
0.33
1.1
1.1
70.4
226.6
titre
3.38
14
126
10
74
1.35
0.32
1.1
2.1
0.5
0.9
u/field
—
10
74
74
674
1.10
0.32
1.1
1.2
—
—
—
0
0
17
137
1.24
0.32
2.1
2.8
—
—
—
0
0
61
550
1.11
0.31
2.7
2.6
—
—
—
0
0
28
327
0.86
0.31
1.2
1.2
—
—
—
0
0
23
273
0.84
0.31
1.7
2.0
—
—
—
0
0
147
1565
0.94
0.31
1.3
1.2
—
—
—
0
0
217
2062
1.05
0.31
1.2
1.3
559.7
455.9
mg/l
0.63
209
1973
88
810
1.09
0.31
1.4
1.4
—
—
—
0
0
30
258
1.16
0.30
1.4
1.5
—
—
—
0
0
8
107
0.75
0.29
1.1
1.0
—
—
—
0
0
217
2070
1.05
0.28
1.1
1.1
1.5
1.7
u/ml
0.06
45
507
12
150
0.80
0.27
1.0
1.1
—
—
—
0
0
63
576
1.09
0.27
2.7
2.5
588.3
507.8
e6/l
0.96
55
470
181
1722
1.05
0.26
1.2
1.3
—
—
—
0
0
22
187
1.18
0.26
1.0
1.0
—
—
—
0
0
67
615
1.09
0.26
1.4
1.6
5.9
5.9
mmol/l
0.04
53
490
8
67
1.19
0.26
1.3
1.5
1.9
4.1
%
—
8
62
29
253
1.15
0.26
1.3
1.5
—
—
—
0
0
355
3432
1.04
0.26
1.7
1.7
—
—
—
0
0
67
616
1.09
0.25
2.8
3.1
—
—
—
0
0
26
299
0.87
0.25
1.2
1.1
—
—
—
0
0
62
568
1.09
0.25
1.2
1.2
217.5
191.7
titre
0.09
12
112
74
684
1.08
0.25
1.2
1.1
1.1
1.1
ratio
0.11
22
258
68
627
1.09
0.25
1.6
1.7
—
—
—
0
0
17
142
1.20
0.24
1.6
1.1
—
—
—
0
0
12
148
0.81
0.24
3.4
7.0
—
—
—
0
0
39
350
1.11
0.24
1.5
1.6
2.7
2.2
u/field
0.16
23
255
19
222
0.86
0.23
1.0
1.0
262.1
331.9
ng/l
1.13
13
164
38
422
0.90
0.23
1.5
1.4
—
—
—
0
0
270
2605
1.04
0.23
2.0
2.2
4.6
5.0
umol/l
0.45
194
1886
199
1909
1.04
0.22
4.0
2.8
—
—
—
0
0
30
266
1.13
0.22
1.1
1.1
—
3.5
iu/ml
—
0
18
15
125
1.20
0.22
2.1
2.0
—
—
—
0
0
127
1205
1.05
0.22
1.2
1.3
—
—
—
0
0
52
477
1.09
0.22
2.8
2.7
146.4
54.1
mg/l
0.39
37
334
71
661
1.07
0.21
1.1
1.2
—
—
—
0
0
247
2559
0.96
0.21
1.2
1.3
—
—
—
0
0
13
107
1.22
0.21
1.3
1.3
—
—
—
0
0
5
42
1.19
0.21
1.0
1.2
286.8
149.3
ug/g
—
5
32
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
55
507
1.09
0.21
1.7
1.6
40.7
40.2
%
0.03
31
300
21
182
1.15
0.21
1.6
1.6
—
—
—
0
0
35
315
1.11
0.21
1.3
1.4
11564.1
2810.6
e6/l
0.46
30
226
123
1170
1.05
0.20
3.6
3.6
—
—
—
0
0
227
2350
0.97
0.20
8.0
7.2
—
—
—
0
0
84
791
1.06
0.19
1.1
1.0
—
—
—
0
0
178
1711
1.04
0.19
1.1
1.1
4.4
3.9
u/ml
0.16
67
705
217
2095
1.04
0.19
1.3
1.3
1138.6
934.0
titre
0.23
14
90
82
870
0.94
0.19
2.4
2.5
1.4
1.4
mmol/l
0.03
82
848
116
1218
0.95
0.19
1.1
1.1
137.8
8538.1
iu/ml
0.63
27
315
189
1821
1.04
0.19
1.1
1.1
3.6
4.3
u/ml
0.19
67
684
45
414
1.09
0.19
2.0
1.6
2.0
1.9
umol/l
0.31
39
385
681
6934
0.98
0.18
1.3
1.3
—
—
—
0
0
28
311
0.90
0.18
2.6
2.4
591.0
610.8
ml
0.13
23
247
16
185
0.86
0.18
1.0
1.0
—
—
—
0
0
25
223
1.12
0.18
2.0
2.2
—
—
—
0
0
7
59
1.19
0.18
1.9
1.9
14.5
14.9
ml/dl
—
7
54
63
590
1.07
0.17
1.3
1.5
—
—
—
0
0
7
61
1.15
0.17
1.9
4.8
—
—
—
0
0
322
3138
1.03
0.17
1.3
1.3
3.8
3.1
ug/l
0.29
294
2884
24
268
0.90
0.17
1.0
1.1
—
—
—
0
0
42
388
1.08
0.16
1.2
1.1
—
—
—
0
0
20
225
0.89
0.16
1.0
1.0
955.7
761.5
ng/l
0.82
14
165
18
204
0.88
0.16
1.1
1.0
5.6
0.6
u/ml
0.42
11
137
16
183
0.87
0.16
1.1
1.1
—
—
—
0
0
380
3718
1.02
0.16
1.1
1.1
—
—
—
0
0
30
328
0.91
0.15
1.1
1.2
—
—
—
0
0
16
140
1.14
0.15
1.1
1.7
—
—
—
0
0
9
83
1.08
0.14
1.6
1.1
—
—
—
0
0
159
1643
0.97
0.14
3.3
3.7
34.7
26.7
u/ml
0.45
149
1589
38
409
0.93
0.14
2.9
3.0
—
—
—
0
0
51
479
1.07
0.14
1.5
1.4
4.4
5.2
u/l
1.84
39
417
164
1692
0.97
0.14
1.5
1.5
7.1
6.7
mmol/l
0.86
122
1220
8
96
0.83
0.13
2.6
2.0
1.2
1.2
mmol/l
—
8
89
21
189
1.11
0.13
1.4
1.5
—
—
—
0
0
8
99
0.81
0.13
2.5
2.3
—
—
—
0
0
55
582
0.94
0.13
1.1
1.1
—
—
—
0
0
16
142
1.13
0.12
1.1
1.1
—
—
—
0
0
294
2881
1.02
0.12
1.8
1.9
20.9
20.7
s
0.34
244
2411
77
804
0.96
0.12
2.5
2.5
6.9
7.2
mmol/l
0.57
77
784
56
532
1.05
0.11
1.1
1.1
—
—
—
0
0
16
143
1.12
0.11
2.5
2.3
403.4
818.6
e6/l
—
10
95
167
1714
0.97
0.11
1.0
1.1
2.5
2.7
u/ml
0.10
96
943
79
759
1.04
0.11
1.0
1.0
1.2
0.7
u/ml
0.20
13
167
76
730
1.04
0.11
1.3
1.3
—
—
—
0
0
130
1337
0.97
0.10
1.4
1.4
30.7
31.6
nmol/l
0.16
123
1229
107
1037
1.03
0.10
1.1
1.2
0.5
1.6
nmol/l
0.53
101
1005
348
3535
0.98
0.10
1.6
1.7
—
—
—
0
0
20
183
1.09
0.10
1.2
1.1
—
—
—
0
0
51
486
1.05
0.10
1.0
1.1
13.2
9.8
u/ml
—
8
86
10
114
0.88
0.09
2.6
2.5
—
—
—
0
0
69
716
0.96
0.09
1.3
1.2
—
—
—
0
0
91
882
1.03
0.09
3.3
3.4
212.1
523.9
u/ml
0.50
85
808
131
1343
0.98
0.09
1.4
1.3
1.5
1.3
nmol/l
0.36
110
1109
27
253
1.07
0.08
1.4
1.2
6.8
5.6
nmol/l
0.83
27
239
33
312
1.06
0.08
1.1
1.2
—
—
—
0
0
47
491
0.96
0.08
1.0
1.1
0.1
3.3
nmol/l
—
7
92
14
154
0.91
0.08
1.1
1.0
—
—
—
0
0
17
156
1.09
0.08
1.2
1.3
—
—
—
0
0
33
348
0.95
0.08
1.2
1.1
—
—
—
0
0
35
368
0.95
0.07
1.1
1.2
—
—
—
0
0
42
439
0.96
0.07
1.9
1.6
1.4
15.2
nmol/l
0.60
35
362
171
1742
0.98
0.07
1.1
1.1
—
—
—
0
0
309
3051
1.01
0.07
1.2
1.2
—
—
—
0
0
64
620
1.03
0.07
1.2
1.2
14.9
26.3
u/l
1.46
57
540
28
295
0.95
0.06
2.4
2.2
1.6
1.2
ug/l
0.37
28
282
91
890
1.02
0.05
1.1
1.2
32.4
36.0
mg/l
0.62
68
751
116
1141
1.02
0.04
3.8
2.7
1.0
0.8
nmol/l
0.90
101
962
10
91
1.10
0.04
1.4
1.2
—
—
—
0
0
246
2437
1.01
0.04
1.1
1.1
0.8
1.2
u/ml
0.45
94
903
15
160
0.94
0.04
1.1
1.1
—
213.3
—
0
9
287
2847
1.01
0.04
1.5
1.5
0.5
0.5
nmol/l
0.27
232
2292
57
557
1.02
0.03
1.1
1.2
7.0
15.5
u/ml
—
6
69
12
129
0.93
0.03
2.7
2.1
1105.8
21904.2
e6/l
—
6
66
185
1834
1.01
0.03
1.2
1.2
3.5
3.6
mmol/l
0.28
176
1717
27
261
1.03
0.02
1.2
1.2
36.7
15.2
%
—
6
41
64
651
0.98
0.02
1.4
1.4
—
—
—
0
0
64
651
0.98
0.02
1.4
1.4
—
—
—
0
0
300
3017
0.99
0.02
1.1
1.1
3.6
4.6
u/ml
0.41
59
477
149
1477
1.01
0.02
2.4
1.9
4.1
1.9
ug/l
0.78
128
1298
65
640
1.02
0.02
1.1
1.2
—
—
—
0
0
64
650
0.98
0.02
1.4
1.4
—
—
—
0
0
64
650
0.98
0.02
1.4
1.4
—
—
—
0
0
184
1827
1.01
0.02
1.2
1.3
82.2
23.8
e6/l
0.41
141
1422
184
1828
1.01
0.02
1.2
1.4
655.8
3443.4
e6/l
0.76
146
1499
220
2190
1.00
0.01
1.0
1.1
5.5
4.8
u/ml
0.24
103
1121
207
2061
1.00
0.01
1.0
1.1
1.4
0.9
u/ml
0.40
76
831
95
943
1.01
0.01
1.8
1.6
—
—
—
0
0
95
943
1.01
0.01
1.9
1.7
30.8
50.5
mu/l
2.41
90
860
12
114
1.05
0.00
1.4
1.2
35.5
38.6
g/l
—
6
65
11
116
0.95
0.00
3.7
2.1
—
—
—
0
0
106
1067
0.99
0.00
2.1
2.3
—
—
—
0
0
71
704
1.01
0.00
1.0
1.1
8.6
7.9
iu/ml
0.12
21
222
28
277
1.01
0.00
1.3
1.4
22371.2
63759.4
e6/l
0.75
21
156
34
343
0.99
0.00
1.3
1.1
—
—
—
0
0
26
256
1.02
0.00
1.1
1.4
—
—
—
0
0
87
867
1.00
0.00
1.5
1.5
343.6
379.8
pmol/l
0.25
70
688
37
366
1.01
0.00
1.1
1.1
—
—
—
0
0
46
464
0.99
0.00
1.7
1.9
5.0
1.8
u/field
0.89
21
225
87
866
1.00
0.00
1.1
1.5
—
—
—
0
0
87
866
1.00
0.00
1.0
1.1
197.0
206.4
mg/l
0.41
72
760
94
936
1.00
0.00
1.1
1.2
—
—
—
0
0
60
595
1.01
0.00
1.1
1.1
309.8
298.9
mg/l
0.59
55
535
12
122
0.98
0.00
9.7
5.8
—
—
—
0
0
28
278
1.01
0.00
1.6
1.5
2.4
4.2
%
—
5
58
38
382
0.99
0.00
1.3
1.2
—
—
—
0
0
44
442
1.00
0.00
1.3
1.2
57.9
69.2
%
—
8
45
38
381
1.00
0.00
1.0
1.0
—
—
—
0
0
28
279
1.00
0.00
1.5
2.2
272.9
174.7
e6/l
0.34
14
152
66
661
1.00
0.00
1.3
1.3
—
—
—
0
0
11
109
1.01
0.00
1.1
1.1
—
—
—
0
0
18
181
0.99
0.00
1.2
1.1
—
—
—
0
0
18
181
0.99
0.00
1.2
1.1
—
—
—
0
0
18
181
0.99
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
49
1.02
0.00
1.4
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
160.2
—
0
5
6
67
0.90
0.00
12.3
9.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
1398.9
—
0
9
7
78
0.90
0.00
3.0
6.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
1.4
1.6
—
—
—
0
0
6
69
0.87
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.6
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
0.5
—
0
7
0
5
0.00
0.00
0.0
2.2
—
5.6
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_FEMALE_GENITAL_HSIL and mortality.

Females

Parameter HR [95% CI] p-value
N14_FEMALE_GENITAL_HSIL 1.321 [1.18, 1.48] < 0.001
Birth year 0.994 [0.99, 1.0] 0.16

During the follow-up period (1.1.1998 — 31.12.2019), 1896 out of 47005 females with N14_FEMALE_GENITAL_HSIL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMALE_GENITAL_HSIL.

N-year risk Females Males
1 0.146% No data
5 0.826% No data
10 1.991% No data
15 3.594% No data
20 6.228% No data

Relationships between endpoints

Index endpoint: N14_FEMALE_GENITAL_HSIL – HSIL lesion of the cervix uteri, vagina or vulva

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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