No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditionsNone |
293218 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
622 |
4. Check minimum number of eventsNone |
622 |
5. Include endpointsNone |
622 |
6. Filter based on genotype QC (FinnGen only) |
594 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
HSIL lesion of the vulva
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the vulva
- HSIL lesion of the cervix uteri, vagina or vulva
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2936 | 2936 | - |
| Only index persons | 2789 | 2789 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.10 | 0.10 | - |
| Median age at first event (years) | |||
| Whole population | - | 55.85 | - |
| Only index persons | - | 55.25 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 594 | 594 | - |
| Unadjusted period prevalence (%) | 0.21 | 0.21 | - |
| Median age at first event (years) | 56.52 | 56.52 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 622
- Matched controls
- 6220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
+∞
314.0
274
*
ULA02
NOMESCO Finland
Kolposcopy
52.6
307.7
507
481
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
+∞
307.7
350
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
104.2
307.7
399
105
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
172.1
307.7
222
20
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
14.1
257.3
379
618
LEB00
NOMESCO Finland
Biopsy of vagina
33.5
230.1
155
61
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
118.6
227.3
116
12
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
1172.2
184.3
171
*
D06BB10
ATC
imiquimod; topical
13.8
163.2
173
169
LFC00
NOMESCO Finland
Partial excision of vulva
557.2
139.0
133
*
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
137.8
127
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
9.5
137.1
199
294
A63.0
ICD-10 Finland
Anogenital (venereal) warts
15.5
133.9
126
100
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
7.4
121.3
233
465
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
9.2
82.1
109
140
N90.0
ICD-10 Finland
Mild vulvar dysplasia
112.2
81.3
87
9
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
31.4
78.6
52
18
N76.6
ICD-10 Finland
Ulceration of vulva
25.2
71.4
51
22
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.1
67.5
113
188
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
7.6
64.0
99
151
N87.0
ICD-10 Finland
Mild cervical dysplasia
9.1
60.3
78
96
D07AD01
ATC
clobetasol; topical
4.1
57.2
221
744
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
16.3
54.2
47
31
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
12.2
53.3
55
49
N90.4
ICD-10 Finland
Leukoplakia of vulva
23.7
52.2
38
17
N87.1
ICD-10 Finland
Moderate cervical dysplasia
9.8
51.9
63
71
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.3
47.9
352
1747
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
8.8
45.1
59
73
D06BB04
ATC
podophyllotoxin; topical
5.7
40.3
81
159
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
60.5
38.9
45
8
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
7.6
37.4
55
78
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
367.0
35.3
35
*
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
+∞
34.7
33
*
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
127.2
34.1
36
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.6
32.5
125
405
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
340.2
32.2
32
*
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
30.5
29
*
N89.0
ICD-10 Finland
Mild vaginal dysplasia
29.6
29.2
39
14
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
26.9
27.8
38
15
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
75.7
26.0
29
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.9
25.1
139
555
L04AA06
ATC
mycophenolic acid; systemic
9.5
24.0
29
32
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.9
22.4
41
73
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
7.9
22.3
31
41
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.2
21.6
96
336
B01AB10
ATC
tinzaparin; parenteral
3.0
21.4
105
389
J02AC01
ATC
fluconazole; systemic
2.3
21.1
375
2506
ZXC10
NOMESCO Finland
Use of laser
6.2
20.2
35
59
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
19.9
19
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
4.3
19.6
52
128
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
103.2
18.7
20
*
WX002
NOMESCO Finland
Sedation and analgesia
2.4
18.4
163
808
P01AB01
ATC
metronidazole; oral, rectal
2.0
16.6
333
2252
WX320
NOMESCO Finland
Spinalanesthesy
2.2
16.3
195
1089
G01AA10
ATC
clindamycin; vaginal
2.2
15.7
168
896
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
58.1
14.8
17
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
14.5
154
816
ZZR00
NOMESCO Finland
Flap of skin
5.9
14.2
26
46
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
5.3
14.2
29
57
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
+∞
13.6
13
*
UKC02
NOMESCO Finland
Cystoscopy
2.6
13.3
87
372
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
6.3
13.0
22
36
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.8
252
1650
LFC96
NOMESCO Finland
Other partial excision of vulva or perineum
+∞
12.5
12
*
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
12.5
12
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.2
12.5
34
85
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
20.5
12.5
18
9
L29.2
ICD-10 Finland
Pruritus vulvae
4.7
12.0
28
62
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.6
11.5
73
307
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
+∞
11.5
11
*
A02BC02
ATC
pantoprazole; systemic
1.9
11.4
446
3562
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.1
11.3
23
26
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.4
11.3
84
380
LCA06
NOMESCO Finland
Biopsy of endometrium
2.0
10.8
129
707
WF002
NOMESCO Finland
Radical radiotherapy
4.0
10.8
31
81
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.0
10.8
147
845
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
10.8
213
1381
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
8.2
10.7
23
29
A11CC03
ATC
alfacalcidol; systemic
5.4
10.7
21
40
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.8
10.6
432
3452
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
111.8
10.4
11
*
B01AB05
ATC
enoxaparin; parenteral
1.8
10.4
222
1468
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
33.1
10.4
13
*
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
33.1
10.4
13
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
10.2
244
1668
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.2
282
2009
X16
ICPC
Vulval symptom/complaint
4.6
10.1
24
54
LFE10
NOMESCO Finland
Plastic repair of vulva
17.0
9.9
15
9
B03XA02
ATC
darbepoetin alfa; parenteral
5.3
9.9
20
39
E0000UV, ,
ATC
1.7
9.9
288
2075
127
Kela drug reimbursment
Transplant complication
8.9
9.8
20
23
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
9.6
57
232
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
9.5
174
1094
L04AX01
ATC
azathioprine; systemic
3.3
9.5
36
114
LFD00
NOMESCO Finland
Vulvectomy
101.5
9.4
10
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
101.5
9.4
10
*
TLC02
NOMESCO Finland
Simple extraction of IUD
2.9
9.4
45
163
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.2
9.4
20
25
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
9.2
256
1811
D07AC01
ATC
betamethasone; topical
1.7
9.2
239
1660
ZXC00
NOMESCO Finland
Use of diathermy
9.2
9.1
18
20
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.0
9.1
104
560
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
9.0
85
425
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.4
8.9
65
291
WX402
NOMESCO Finland
General anaesthesia
1.9
8.9
143
862
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
8.9
154
950
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.8
8.7
26
70
L57.0
ICD-10 Finland
Actinic keratosis
2.2
8.6
75
363
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.2
8.6
17
19
E000001, ,
ATC
1.8
8.6
142
864
G01AF01
ATC
metronidazole; vaginal
2.0
8.5
100
542
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
27.9
8.5
11
*
128
Kela drug reimbursment
Cancers of female genital organs
3.7
8.5
27
76
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.0
8.4
18
37
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
5.0
8.4
18
37
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.4
267
1946
8077/2-C51.1
ICD-O-3
Squamous intraepithelial neoplasia, high grade of labium minus
+∞
8.3
8
*
LEB10
NOMESCO Finland
Excision of lesion of vagina
11.9
8.1
14
12
ZXE00
NOMESCO Finland
One hour or less
1.6
8.1
263
1922
R03AC02
ATC
salbutamol; inhalant
1.6
8.0
375
2997
L04AA01
ATC
[U] ciclosporin
6.7
7.9
19
29
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.0
7.9
85
446
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
7.9
69
334
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
7.9
35
122
N02BE01
ATC
paracetamol; systemic, rectal
2.3
7.8
571
5158
R2110
NOMESCO Finland
Giving the first information
2.3
7.8
60
276
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
18.6
7.6
11
6
LFW96
NOMESCO Finland
Other operation on vulva or perineum
25.4
7.6
10
*
Z94.0
ICD-10 Finland
Kidney transplant status
10.2
7.6
14
14
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
10.2
7.6
14
14
TQW80
NOMESCO Finland
Local dermatologic skincare
4.0
7.5
21
54
C03CA01
ATC
furosemide; systemic
1.7
7.4
167
1105
J01AA02
ATC
doxycycline; systemic
1.8
7.4
503
4374
J01EA01
ATC
trimethoprim; systemic
1.6
7.4
215
1520
WX702
NOMESCO Finland
Supraglottic ventilation device
2.4
7.3
49
211
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
4.2
7.3
19
46
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
7.3
82
437
TQW40
NOMESCO Finland
Remowal of suture of skin
2.3
7.2
54
245
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.2
7.1
28
91
D05BB02
ATC
acitretin; oral
4.3
7.1
18
43
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.5
7.0
44
184
UJF32
NOMESCO Finland
Coloscopy
1.7
7.0
166
1112
J01DB01
ATC
cefalexin; oral
1.8
7.0
520
4591
A12AA04
ATC
calcium carbonate; oral
7.7
6.9
15
20
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
14.0
6.9
11
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
14.0
6.9
11
8
J01FF01
ATC
clindamycin; systemic
1.7
6.9
172
1168
R50.9
ICD-10 Finland
Fever, unspecified
1.9
6.8
91
514
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.8
172
1169
LFE96
NOMESCO Finland
Other repair of vulva or perineum
40.5
6.8
8
*
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
40.5
6.8
8
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
6.7
152
1005
SPAT1153
SPAT
Removal of sutures
1.6
6.7
198
1400
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.7
6.7
157
1048
Z3231
NOMESCO Finland
Registered nurse
1.6
6.6
170
1160
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
10.2
6.6
12
12
M79.6
ICD-10 Finland
Pain in limb
1.5
6.5
283
2180
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
6.5
77
417
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.5
234
1730
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
6.5
246
1840
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
6.5
230
1695
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
70.5
6.4
7
*
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
70.5
6.4
7
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.5
6.4
40
167
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
14.5
6.4
10
7
Z2221
NOMESCO Finland
Medical doctor
1.6
6.3
186
1309
N94.1
ICD-10 Finland
Dyspareunia
5.6
6.3
17
31
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
6.1
6.3
16
27
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.3
169
1163
L04AD02
ATC
tacrolimus; systemic
9.4
6.3
12
13
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
6.3
129
829
R51.80
ICD-10 Finland
Headache
1.7
6.2
115
717
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
27.0
6.2
8
*
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
6.4
6.2
15
24
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.4
6.2
43
189
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
6.1
96
571
137
Kela drug reimbursment
Uraemia requiring dialysis
12.7
6.1
10
8
WX882
NOMESCO Finland
High dependency care
3.7
6.1
19
53
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.2
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
32
22.18
84.67
2.9
1.5
—
—
—
0
0
145
304
5.92
68.67
2.5
1.4
—
—
—
0
0
340
1404
4.14
67.55
2.6
1.4
—
—
—
0
0
39
12
34.56
30.35
1.8
2.3
8.40
2.50
ug/l
—
26
5
392
2551
2.45
25.20
3.2
2.4
—
—
—
0
0
225
1263
2.22
19.03
2.6
2.0
—
—
—
0
0
378
2767
1.93
13.96
6.3
5.3
9.23
10.01
umol/l
1.42
360
2614
321
2234
1.90
13.77
6.4
4.0
35.75
35.89
g/l
0.19
306
2075
506
4156
2.17
12.78
9.6
6.8
79.10
76.65
u/l
0.73
486
3896
33
81
4.25
12.45
5.4
4.9
243.71
127.00
iu/ml
—
7
7
231
1498
1.86
11.89
4.1
3.0
17.15
64.74
e6/l
2.56
187
1129
141
778
2.05
11.67
3.6
2.8
0.78
0.81
mmol/l
3.12
133
723
231
1510
1.84
11.51
4.7
2.9
6.21
6.56
mmol/l
0.64
191
1275
307
2220
1.76
10.65
16.4
12.7
1.22
1.17
inr
0.44
79
672
173
1055
1.89
10.59
3.1
2.4
9.85
8.06
e6/l
0.30
157
957
350
2635
1.75
10.46
7.5
5.7
1.21
1.22
mmol/l
1.45
288
2232
357
2717
1.74
10.13
4.5
3.8
0.00
0.01
estimate
0.80
69
507
242
1655
1.76
10.06
3.8
2.2
57.46
58.88
u/l
0.12
227
1533
210
1380
1.79
10.00
4.4
2.9
0.22
0.44
e6/l
1.86
170
1026
353
2693
1.72
9.80
5.9
5.1
0.00
0.00
estimate
0.50
68
511
377
2954
1.70
9.25
5.5
4.1
6.67
6.52
mmol/l
0.61
359
2738
318
2382
1.69
9.24
6.3
5.0
1.22
1.22
mmol/l
0.77
282
2168
396
3147
1.71
9.19
10.9
8.3
4.03
3.92
e9/l
0.53
355
2768
104
565
2.01
8.82
2.8
2.1
6.03
6.31
umol/l
0.08
93
479
598
5483
3.35
8.64
22.2
14.1
3.92
3.93
mmol/l
0.25
590
5318
597
5471
3.27
8.59
22.0
14.0
139.47
139.67
mmol/l
1.11
588
5322
130
770
1.87
8.53
2.1
1.8
—
—
—
0
0
73
357
2.18
8.15
1.7
1.5
—
—
—
0
0
213
1478
1.67
8.00
5.1
3.6
13.06
6.79
mg/mmol
0.84
139
847
584
5349
2.50
7.34
21.1
12.6
20.99
20.86
mg/l
0.03
491
4163
195
1347
1.65
7.34
2.6
2.9
814.10
1030.87
ng/l
0.56
163
1134
326
2561
1.57
7.10
8.3
5.3
58.09
56.79
%
1.17
306
2385
329
2591
1.57
7.08
8.8
5.6
27.92
28.88
%
0.88
311
2419
101
589
1.85
6.88
9.6
3.9
1.07
1.04
mmol/l
0.51
94
532
131
827
1.74
6.84
3.8
2.5
1.48
1.21
e6/l
0.29
85
441
106
631
1.82
6.75
2.1
2.0
—
—
—
0
0
216
1565
1.58
6.55
2.3
2.1
117.04
149.10
u/l
1.47
204
1472
336
2689
1.54
6.52
4.5
3.8
0.00
0.00
estimate
-0.00
68
545
89
511
1.87
6.35
2.6
2.1
366.64
371.22
nmol/l
0.07
81
473
602
5656
3.00
6.03
22.4
14.5
71.47
68.91
umol/l
1.06
602
5656
85
494
1.83
5.83
5.1
6.3
0.20
1.45
mmol/l
1.96
65
398
72
397
1.92
5.81
4.8
2.8
1.76
2.24
mmol/l
0.53
60
335
557
5090
1.90
5.75
17.6
11.6
81.28
81.89
ml/min/173m2
0.26
490
4149
278
2176
1.50
5.74
2.2
2.0
98.52
98.29
pmol/l
0.02
131
1058
308
2463
1.50
5.72
2.6
2.3
82.06
78.26
nmol/l
1.40
266
2214
94
568
1.77
5.67
2.1
1.9
—
—
—
0
0
175
1253
1.55
5.42
1.8
1.7
0.88
0.93
mg/l
0.21
140
942
22
74
3.05
5.31
1.9
1.3
—
—
—
0
0
17
49
3.54
5.20
1.1
1.1
—
—
—
0
0
139
957
1.58
5.08
1.7
1.7
1188.21
1245.62
nmol/l
0.30
109
710
506
4546
1.61
5.01
4.9
4.5
14.84
14.69
pmol/l
0.50
472
4177
87
536
1.72
4.90
2.0
1.8
—
—
—
0
0
102
657
1.66
4.87
8.0
5.8
—
—
—
0
0
114
757
1.62
4.83
4.0
2.7
3.24
4.55
e6/l
1.00
69
370
462
4084
1.51
4.76
5.7
4.1
13.44
12.08
mm/h
1.26
431
3777
66
378
1.83
4.75
1.6
1.7
—
—
—
0
0
560
5189
1.79
4.63
6.1
5.3
1.77
2.08
mu/l
0.72
527
4797
17
54
3.21
4.51
1.2
1.4
—
—
—
0
0
39
189
2.13
4.51
1.6
2.3
1.77
1.51
g/l
0.77
33
169
98
638
1.64
4.48
4.1
2.2
22.44
21.72
%
0.22
80
536
613
5929
3.34
4.48
30.4
18.9
39.02
39.44
%
1.15
586
5566
132
925
1.54
4.42
3.9
3.7
65.50
286.14
ng/l
1.81
93
666
190
1436
1.47
4.42
4.9
4.1
0.00
0.00
estimate
0.80
68
516
598
5679
2.37
4.39
14.2
9.8
23.96
23.33
u/l
0.46
582
5478
13
28
4.72
4.39
1.6
2.1
—
—
—
0
0
48
255
1.96
4.34
5.8
3.2
1.30
1.86
mmol/l
0.44
41
198
613
5934
3.28
4.34
30.6
19.1
130.50
131.93
g/l
2.04
606
5853
613
5933
3.29
4.34
30.3
19.0
4.33
4.40
e12/l
3.64
601
5777
613
5930
3.33
4.32
30.4
19.0
266.29
262.34
e9/l
0.81
602
5793
53
293
1.88
4.27
1.6
1.6
—
—
—
0
0
84
533
1.67
4.24
1.9
1.7
—
—
—
0
0
103
692
1.59
4.14
3.8
2.1
2.21
2.43
g/l
4.77
91
637
240
1921
1.41
4.01
4.2
3.2
2.36
2.36
mmol/l
0.17
206
1702
36
178
2.09
3.97
2.5
1.7
—
—
—
0
0
35
172
2.10
3.93
1.2
1.4
368.05
310.40
ug/g
0.65
21
98
38
193
2.03
3.91
2.4
1.8
—
—
—
0
0
29
133
2.24
3.86
1.3
1.2
—
—
—
0
0
109
755
1.54
3.83
3.9
2.2
12.30
13.15
umol/l
0.63
96
694
6
5
12.10
3.77
3.5
3.4
—
—
—
0
0
17
62
2.79
3.61
1.2
1.4
—
—
—
0
0
144
1069
1.45
3.60
1.6
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
124
2.23
3.59
2.4
2.8
0.40
0.40
u/ml
0.01
16
75
82
540
1.60
3.58
1.8
1.5
1.33
1.34
%
0.04
71
480
35
179
2.01
3.56
1.4
1.2
19.00
2.28
u/ml
—
8
20
252
2067
1.37
3.52
4.8
3.9
—
—
—
0
0
300
2533
1.36
3.47
3.5
2.8
107.73
84.49
ug/l
1.45
271
2341
19
76
2.55
3.41
1.6
2.9
1.58
1.24
%
0.13
19
69
398
3519
1.36
3.36
3.3
3.2
—
—
—
0
0
24
108
2.27
3.36
1.4
1.5
—
—
—
0
0
35
183
1.97
3.36
1.4
1.2
6.85
8.94
u/ml
—
10
32
164
1262
1.41
3.34
2.7
2.3
4889.61
6495.50
umol/l
0.19
144
1103
17
65
2.66
3.33
1.4
1.6
—
—
—
0
0
15
54
2.82
3.27
1.1
1.5
—
—
—
0
0
13
43
3.07
3.26
1.4
1.0
—
—
—
0
0
526
4888
1.49
3.25
6.8
5.3
39.32
39.07
mmol/mol
0.25
494
4527
26
124
2.14
3.18
1.7
1.5
—
—
—
0
0
18
73
2.51
3.15
1.2
1.5
—
—
—
0
0
13
44
3.00
3.15
1.6
1.5
—
—
—
0
0
13
44
3.00
3.15
1.6
1.5
—
—
—
0
0
41
232
1.82
3.12
2.2
2.0
1987.48
3933.89
u/l
0.46
13
98
12
35
3.48
3.12
1.3
1.6
—
—
—
0
0
228
1869
1.35
3.11
3.8
3.4
17.21
29.26
ng/l
1.89
144
1191
173
1358
1.38
3.11
1.3
1.3
0.62
1.75
u/ml
2.07
39
367
22
101
2.22
2.96
1.5
1.6
—
—
—
0
0
158
1231
1.38
2.96
1.5
1.5
22.46
22.08
nmol/l
0.10
137
1046
34
185
1.89
2.93
1.1
1.1
—
—
—
0
0
57
362
1.63
2.91
2.4
3.0
195.45
186.32
ng/l
0.05
51
336
167
1318
1.37
2.88
2.9
2.1
3.04
3.04
mg/l
0.01
140
1118
6
9
6.72
2.87
1.0
1.0
—
—
—
0
0
91
648
1.47
2.80
4.7
4.3
34.02
33.50
%
0.15
62
422
19
84
2.30
2.79
1.4
1.3
—
—
—
0
0
67
450
1.55
2.72
2.6
2.9
231.28
55.08
u/ml
0.43
67
431
18
79
2.32
2.70
1.3
1.2
—
—
—
0
0
390
3495
1.31
2.69
4.0
2.9
52.17
42.43
u/l
1.11
365
3264
58
378
1.59
2.68
2.1
2.3
2.10
4.76
ug/l
4.54
49
330
33
184
1.84
2.66
1.2
1.1
—
—
—
0
0
11
35
3.18
2.65
1.4
1.4
—
—
—
0
0
23
113
2.08
2.65
1.3
1.7
—
—
—
0
0
12
41
2.96
2.63
1.3
1.5
—
—
—
0
0
71
489
1.51
2.58
3.5
2.2
28.33
33.84
u/l
1.12
60
405
56
366
1.58
2.56
1.3
1.3
—
42.00
—
0
23
12
44
2.76
2.56
1.9
2.7
54.75
50.42
%
0.33
12
38
22
108
2.08
2.54
2.0
2.3
—
—
—
0
0
23
115
2.04
2.54
5.8
3.7
57.35
58.18
%
0.11
23
115
9
26
3.50
2.49
1.1
1.2
—
—
—
0
0
16
70
2.32
2.43
1.6
1.4
—
—
—
0
0
16
70
2.32
2.43
1.6
1.4
—
—
—
0
0
536
5066
1.42
2.38
4.4
3.8
1.32
1.24
mmol/l
2.24
493
4648
63
432
1.51
2.35
5.5
3.0
109.00
77.58
ng/l
1.63
56
384
148
1181
1.33
2.34
4.7
4.1
1.01
1.02
kg/l
0.84
23
172
17
78
2.21
2.33
1.5
1.6
—
—
—
0
0
18
85
2.15
2.30
1.3
1.2
—
—
—
0
0
14
59
2.40
2.30
1.0
1.1
—
—
—
0
0
22
113
1.98
2.28
5.9
3.4
3.56
4.34
e9/l
1.31
22
113
72
512
1.46
2.25
3.4
3.3
—
—
—
0
0
25
135
1.89
2.25
1.2
1.2
—
—
—
0
0
18
86
2.13
2.25
1.0
1.0
2.59
1.62
u/ml
—
9
43
206
1730
1.29
2.23
3.8
2.8
30.52
29.62
u/l
0.24
197
1655
10
35
2.89
2.21
1.3
1.9
—
—
—
0
0
35
211
1.70
2.21
5.3
1.7
—
—
—
0
0
130
1026
1.34
2.21
3.3
2.6
2.47
2.45
mmol/l
0.63
111
909
43
276
1.60
2.15
1.6
1.7
—
—
—
0
0
59
409
1.49
2.10
2.4
2.4
21.13
24.64
au/ml
—
7
31
8
25
3.23
2.10
2.4
1.3
—
—
—
0
0
5
10
5.03
2.07
1.6
1.1
—
—
—
0
0
32
192
1.70
2.07
5.6
1.4
1.10
1.22
g/l
1.08
32
180
31
185
1.71
2.05
5.7
1.5
0.23
0.24
g/l
0.14
31
176
49
331
1.52
1.98
1.6
1.3
—
—
—
0
0
61
433
1.45
1.95
2.0
2.4
60.00
69.04
ml/min/173m2
0.47
17
175
8
27
2.99
1.94
1.0
1.0
—
—
—
0
0
56
392
1.47
1.92
3.7
3.4
4.54
4.55
pmol/l
0.03
47
342
56
396
1.46
1.83
1.6
2.8
65.22
67.77
g/l
1.10
47
364
137
1118
1.29
1.83
1.6
1.6
458.41
29189639.70
pmol/l
1.31
107
925
5
12
4.19
1.82
1.2
1.1
—
—
—
0
0
9
35
2.59
1.80
1.0
1.3
—
—
—
0
0
34
216
1.61
1.80
3.5
2.8
25.33
25.46
mmol/l
0.09
34
211
25
146
1.74
1.80
1.1
1.3
—
—
—
0
0
14
67
2.11
1.77
1.7
1.3
—
—
—
0
0
41
274
1.53
1.76
3.2
2.6
123.39
128.57
g/l
0.95
41
268
23
133
1.76
1.72
2.0
1.9
178.22
196.15
ug/l
0.10
23
116
14
68
2.08
1.71
1.7
1.3
—
—
—
0
0
14
68
2.08
1.71
1.7
1.3
—
—
—
0
0
11
48
2.31
1.71
1.2
1.3
—
—
—
0
0
544
5216
1.34
1.66
5.5
4.4
5.89
5.80
mmol/l
0.90
497
4776
19
105
1.84
1.64
3.1
1.9
120.73
129.49
g/l
0.85
11
75
32
206
1.58
1.63
2.4
2.1
0.66
0.63
%
0.18
32
206
8
32
2.52
1.60
1.1
1.2
—
—
—
0
0
24
144
1.69
1.60
1.1
1.1
—
—
—
0
0
10
44
2.29
1.56
2.9
2.1
—
—
—
0
0
14
71
1.99
1.55
1.7
1.3
—
—
—
0
0
14
71
1.99
1.55
1.7
1.3
—
—
—
0
0
14
71
1.99
1.55
1.7
1.3
—
—
—
0
0
8
33
2.44
1.54
2.0
1.3
61.87
69.24
umol/l
—
8
33
7
27
2.61
1.52
1.1
1.4
—
—
—
0
0
7
27
2.61
1.52
1.1
1.4
—
—
—
0
0
32
212
1.54
1.46
2.5
2.1
1.28
1.14
%
0.47
32
212
5
16
3.14
1.44
1.0
1.1
521.00
389.64
pmol/l
—
5
11
40
281
1.45
1.40
1.3
1.5
—
—
—
0
0
29
191
1.54
1.37
1.6
1.3
304.27
249.46
miu/ml
0.32
11
92
5
18
2.79
1.28
1.2
1.1
—
—
—
0
0
5
18
2.79
1.28
1.2
1.1
—
—
—
0
0
11
55
2.02
1.28
1.5
1.6
—
—
—
0
0
546
5276
1.29
1.26
4.9
4.2
1.54
1.59
mmol/l
1.88
502
4883
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
32
221
1.47
1.24
1.7
2.2
34.13
39.91
u/l
0.72
25
200
27
180
1.52
1.23
1.3
1.9
—
—
—
0
0
24
156
1.56
1.22
1.8
1.9
93.75
97.92
%
0.39
24
149
8
37
2.18
1.21
1.1
1.2
—
—
—
0
0
557
5402
1.30
1.19
5.6
4.7
2.74
2.84
mmol/l
1.86
514
4998
6
26
2.32
1.19
1.2
1.2
—
—
—
0
0
6
26
2.32
1.19
1.2
1.2
—
—
—
0
0
39
284
1.40
1.15
1.6
1.4
—
—
—
0
0
8
39
2.06
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.2
1.4
—
—
—
0
0
16
95
1.70
1.14
1.6
1.2
—
—
—
0
0
16
95
1.70
1.14
1.6
1.2
—
—
—
0
0
7
31
2.27
1.10
1.1
1.4
—
—
—
0
0
8
41
1.96
1.09
1.1
1.6
—
—
—
0
0
11
59
1.88
1.08
2.1
1.9
65.33
56.74
%
—
6
38
547
5306
1.26
1.07
5.1
4.2
4.72
4.85
mmol/l
2.13
508
4934
33
238
1.41
1.05
2.7
2.6
0.28
0.17
e6/l
0.25
33
229
9
46
1.97
1.04
1.0
1.0
—
—
—
0
0
165
1459
1.18
1.02
1.8
1.6
1.41
1.35
mmol/l
0.38
144
1240
20
131
1.54
1.01
1.2
1.4
36.73
4.98
e6/l
0.41
15
98
16
99
1.63
1.01
3.7
2.3
15.82
16.10
%
—
9
48
18
115
1.58
1.00
1.7
1.3
—
—
—
0
0
11
61
1.82
0.99
1.8
2.2
—
—
—
0
0
5
23
2.18
0.98
1.2
1.0
—
—
—
0
0
7
36
1.95
0.97
1.4
1.1
—
—
—
0
0
41
312
1.34
0.96
1.0
1.0
—
—
—
0
0
6
120
0.50
0.94
2.0
1.6
—
—
—
0
0
6
28
2.15
0.91
3.3
3.6
800.17
1118.46
u/ml
—
6
28
22
151
1.47
0.91
1.4
1.2
763.55
462.65
mg/l
0.41
22
139
49
388
1.29
0.88
1.4
1.2
421.95
158.60
u/ml
0.46
44
362
15
95
1.59
0.88
1.0
1.2
2.22
5.89
u/ml
—
9
35
6
31
1.94
0.84
1.3
1.6
0.40
1.27
promille
—
6
24
8
47
1.71
0.81
2.8
3.6
—
—
—
0
0
6
33
1.83
0.79
1.8
1.4
14.67
25.81
ug/l
—
6
33
5
98
0.51
0.78
1.4
1.5
—
—
—
0
0
6
34
1.77
0.76
1.0
1.1
—
—
—
0
0
5
25
2.01
0.73
1.8
3.0
—
—
—
0
0
10
60
1.68
0.72
2.7
1.6
6.03
69.14
u/ml
—
10
60
53
437
1.23
0.71
4.8
3.5
1.23
1.23
mmol/l
0.47
45
378
23
308
0.74
0.71
1.5
1.5
—
—
—
0
0
7
43
1.63
0.67
1.0
1.9
—
—
—
0
0
19
137
1.40
0.65
2.2
1.4
—
—
—
0
0
56
474
1.20
0.60
1.1
1.2
94.35
159.76
iu/ml
0.71
16
199
25
192
1.31
0.60
1.5
2.1
—
—
—
0
0
23
176
1.32
0.57
1.3
1.6
—
—
—
0
0
25
195
1.29
0.55
1.4
1.7
—
—
—
0
0
120
1089
1.13
0.54
1.3
1.3
23.99
31.96
iu/ml
0.63
31
365
11
74
1.50
0.53
4.4
5.3
321.18
387.15
umol/l
1.35
11
66
10
66
1.52
0.53
1.0
1.1
—
—
—
0
0
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
13
94
1.39
0.46
1.0
1.1
1.29
1.93
u/ml
—
7
27
20
156
1.29
0.45
1.9
1.6
—
175.00
—
0
8
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
102.20
—
0
15
0
19
0.00
0.39
0.0
1.8
—
5.88
—
0
12
9
67
1.35
0.38
1.1
1.1
—
—
—
0
0
10
135
0.74
0.36
1.3
1.5
—
—
—
0
0
11
83
1.33
0.32
1.9
1.7
—
—
—
0
0
17
208
0.81
0.31
1.5
1.5
—
—
—
0
0
11
85
1.30
0.28
1.1
1.1
—
—
—
0
0
57
520
1.11
0.27
3.4
3.6
3.87
9.40
ug/l
2.47
42
412
16
193
0.82
0.27
1.6
1.5
—
—
—
0
0
15
182
0.82
0.26
1.3
1.4
—
—
—
0
0
15
182
0.82
0.26
1.3
1.4
—
—
—
0
0
15
181
0.82
0.25
1.3
1.4
—
—
—
0
0
15
181
0.82
0.25
1.3
1.4
—
—
—
0
0
5
41
1.22
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
0.49
—
0
7
0
12
0.00
0.21
0.0
1.0
—
114.58
—
0
12
20
227
0.88
0.18
1.2
1.8
2.22
2.41
mg/l
0.09
15
170
44
475
0.92
0.17
1.6
1.6
—
—
—
0
0
7
62
1.13
0.17
1.1
1.2
—
—
—
0
0
20
177
1.13
0.16
2.8
1.8
2.59
5.19
iu/l
—
9
59
16
183
0.87
0.16
3.9
2.8
18.27
909.27
u/ml
0.65
11
160
8
71
1.13
0.16
4.5
2.2
13.18
13.36
%
—
8
71
18
160
1.13
0.14
1.1
1.2
—
—
—
0
0
110
1068
1.04
0.10
1.3
1.3
2.33
10.91
u/ml
4.72
33
412
14
125
1.12
0.10
3.1
1.8
9281.00
17358.87
e6/l
0.62
14
87
36
340
1.06
0.09
1.2
1.3
37.11
30.49
iu/l
0.41
29
302
7
64
1.09
0.08
1.6
2.1
105.57
105.48
mmol/l
—
7
64
10
90
1.11
0.05
1.4
1.6
—
—
—
0
0
12
110
1.09
0.05
1.2
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
-0.00
1.3
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
0.57
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
75.00
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_VULVAL_HSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VULVAL_HSIL | 1.464 [1.23, 1.74] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.114 |
During the follow-up period (1.1.1998 — 31.12.2019), 378 out of 2373 females with N14_VULVAL_HSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VULVAL_HSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | No data |
| 5 | 0.772% | No data |
| 10 | 2.04% | No data |
| 15 | 3.618% | No data |
| 20 | 6.301% | No data |
Relationships between endpoints
↥Index endpoint: N14_VULVAL_HSIL – HSIL lesion of the vulva
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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