No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
587 |
4. Check minimum number of eventsNone |
587 |
5. Include endpointsNone |
587 |
6. Filter based on genotype QC (FinnGen only) |
587 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
HSIL lesion of the vulva
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the vulva
- HSIL lesion of the cervix uteri, vagina or vulva
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2936 | 2936 | - |
| Only index persons | 2789 | 2789 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.10 | 0.10 | - |
| Median age at first event (years) | |||
| Whole population | - | 55.85 | - |
| Only index persons | - | 55.25 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 587 | 587 | - |
| Unadjusted period prevalence (%) | 0.20 | 0.20 | - |
| Median age at first event (years) | 56.51 | 56.51 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 508
- Matched controls
- 5079
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
+∞
311.6
266
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
115.0
305.9
319
73
ULA02
NOMESCO Finland
Kolposcopy
49.5
290.5
406
377
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
+∞
272.1
236
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
108.8
168.3
178
25
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
+∞
142.6
130
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
12.3
133.3
301
537
LFC00
NOMESCO Finland
Partial excision of vulva
711.4
118.1
112
*
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
115.1
106
*
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
134.4
93.8
98
9
LEB00
NOMESCO Finland
Biopsy of vagina
35.9
87.3
113
40
D06BB10
ATC
imiquimod; topical
16.6
75.3
126
99
N90.0
ICD-10 Finland
Mild vulvar dysplasia
132.6
65.7
69
6
A63.0
ICD-10 Finland
Anogenital (venereal) warts
17.7
63.8
103
72
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
8.7
62.8
150
234
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
6.4
57.6
177
392
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
13.1
49.4
90
82
D07AD01
ATC
clobetasol; topical
4.7
42.1
172
501
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.6
40.9
292
1385
LDA10
NOMESCO Finland
Curettage of cervix uteri
6.9
32.8
87
148
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
49.6
31.0
37
8
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
68.1
28.3
32
5
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
30.2
25.7
34
12
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
5.7
25.6
77
153
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
94.9
24.9
27
*
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
262.2
24.9
25
*
N87.0
ICD-10 Finland
Mild cervical dysplasia
8.3
24.6
56
75
D06BB04
ATC
podophyllotoxin; topical
6.2
23.3
65
117
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
87.5
22.9
25
*
N90.4
ICD-10 Finland
Leukoplakia of vulva
28.9
22.5
30
11
N89.0
ICD-10 Finland
Mild vaginal dysplasia
54.6
22.3
26
5
N87.1
ICD-10 Finland
Moderate cervical dysplasia
8.1
22.3
51
69
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
22.0
21
*
N76.6
ICD-10 Finland
Ulceration of vulva
19.3
20.7
31
17
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.6
20.2
100
323
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
19.9
19
*
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
17.6
19.4
30
18
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
45.8
18.4
22
5
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
38.2
17.7
22
6
J02AC01
ATC
fluconazole; systemic
2.2
16.3
303
2040
B01AB10
ATC
tinzaparin; parenteral
4.0
16.2
67
184
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
87.8
15.6
17
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
5.9
14.5
41
75
WX002
NOMESCO Finland
Sedation and analgesia
2.5
14.1
132
633
WX320
NOMESCO Finland
Spinalanesthesy
2.3
14.0
153
793
G01AA10
ATC
clindamycin; vaginal
2.4
13.8
142
714
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
6.0
13.7
38
68
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.1
12.6
75
272
P01AB01
ATC
metronidazole; oral, rectal
2.0
12.6
261
1760
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
12.5
12
*
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
20.7
12.5
18
9
L04AA06
ATC
mycophenolic acid; systemic
10.4
12.1
23
23
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.5
11.7
97
432
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.5
11.7
34
65
ZXC10
NOMESCO Finland
Use of laser
6.4
10.9
28
46
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
61.3
10.7
12
*
J01MA02
ATC
ciprofloxacin; systemic
1.9
10.6
206
1329
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
7.6
10.6
24
33
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
33.3
10.4
13
*
UKC02
NOMESCO Finland
Cystoscopy
2.7
10.2
73
297
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.6
10.2
76
317
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
10.2
115
594
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
40.9
10.0
12
*
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
101.8
9.4
10
*
LFC96
NOMESCO Finland
Other partial excision of vulva or perineum
+∞
9.4
9
*
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
+∞
9.4
9
*
LFE10
NOMESCO Finland
Plastic repair of vulva
15.9
9.1
14
9
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
37.4
9.0
11
*
LCA06
NOMESCO Finland
Biopsy of endometrium
2.2
8.9
103
536
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.9
8.8
54
199
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
8.6
180
1171
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.5
8.5
39
119
LFD00
NOMESCO Finland
Vulvectomy
+∞
8.4
8
*
E000001
ATC
NA
2.0
8.3
117
661
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
8.2
164
1048
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
8.2
208
1438
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
8.3
8.1
17
21
E0000UV
ATC
NA
1.7
8.1
216
1511
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.1
144
882
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
8.7
7.9
16
19
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
45.7
7.7
9
*
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
5.1
7.7
23
47
UJF32
NOMESCO Finland
Coloscopy
1.8
7.6
139
861
J01AA02
ATC
doxycycline; systemic
1.9
7.5
411
3528
M79.6
ICD-10 Finland
Pain in limb
1.7
7.5
202
1411
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
81.2
7.4
8
*
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
+∞
7.3
7
*
LFW96
NOMESCO Finland
Other operation on vulva or perineum
30.5
7.2
9
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
7.2
122
735
X16
ICPC
Vulval symptom/complaint
5.4
7.1
20
38
TAC99
NOMESCO Finland
Other blockade for chronic pain
12.2
7.1
12
10
A02BC02
ATC
pantoprazole; systemic
1.7
7.1
342
2796
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.4
7.0
24
57
WX702
NOMESCO Finland
Supraglottic ventilation device
2.8
7.0
42
156
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
7.0
86
458
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.7
6.9
15
20
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.7
6.9
328
2656
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.9
123
751
L04AX01
ATC
azathioprine; systemic
3.4
6.9
31
94
127
Kela drug reimbursment
Transplant complication
8.4
6.9
14
17
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
40.6
6.8
8
*
L04AA01
ATC
[U] ciclosporin; systemic
7.3
6.7
15
21
B01AB05
ATC
enoxaparin; parenteral
1.7
6.6
167
1133
L29.2
ICD-10 Finland
Pruritus vulvae
5.1
6.5
19
38
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.3
6.5
16
26
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
70.7
6.4
7
*
WF002
NOMESCO Finland
Radical radiotherapy
4.3
6.4
22
53
LEB10
NOMESCO Finland
Excision of lesion of vagina
8.3
6.4
13
16
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.3
209
1524
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
4.2
6.3
22
54
T89
ICPC
Diabetes insulin dependent
4.0
6.3
23
59
SPAT1153
SPAT
Removal of sutures
1.7
6.2
157
1061
ZXC00
NOMESCO Finland
Use of diathermy
7.8
6.2
13
17
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
6.1
40
157
J01DB01
ATC
cefalexin; oral
1.8
6.1
415
3644
ZZR00
NOMESCO Finland
Flap of skin
4.2
6.1
21
51
G01AF01
ATC
metronidazole; vaginal
2.0
6.1
83
460
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.0
201
1463
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
6.0
69
355
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
30
23.40
85.12
2.9
1.5
—
—
—
0
0
320
1320
4.13
63.69
2.6
1.4
—
—
—
0
0
132
288
5.62
59.58
2.5
1.4
—
—
—
0
0
369
2409
2.43
23.43
4.9
3.8
—
—
—
0
0
213
1181
2.26
18.74
2.6
2.0
—
—
—
0
0
305
2116
1.92
13.35
6.5
3.9
35.6
35.9
g/l
0.34
291
1958
476
3924
2.13
11.64
9.5
6.8
79.1
76.6
u/l
0.69
453
3673
351
2629
1.83
11.32
6.4
5.3
9.3
10.1
umol/l
1.40
332
2479
133
740
2.03
10.76
3.4
2.8
0.8
0.8
mmol/l
2.41
126
683
219
1447
1.82
10.48
4.7
2.9
6.1
6.6
mmol/l
0.88
182
1206
333
2518
1.75
9.78
7.3
5.7
1.2
1.2
mmol/l
1.31
272
2118
29
78
3.86
9.71
4.8
5.1
243.7
127.0
iu/ml
—
7
7
338
2578
1.73
9.52
4.5
3.8
0.0
0.0
estimate
0.80
61
477
334
2556
1.71
9.14
6.0
5.2
0.0
0.0
estimate
0.50
60
480
198
1322
1.75
8.85
4.2
2.9
0.2
0.4
e6/l
1.81
155
980
226
1568
1.72
8.79
3.7
2.3
54.0
55.8
u/l
0.42
212
1447
303
2274
1.69
8.79
6.0
5.0
1.2
1.2
mmol/l
0.53
263
2059
372
2956
1.71
8.63
10.6
8.4
4.0
3.9
e9/l
0.40
332
2592
563
5179
3.13
7.64
22.3
14.2
3.9
3.9
mmol/l
0.20
555
5020
562
5167
3.06
7.59
22.1
14.1
139.5
139.7
mmol/l
1.05
553
5024
14
25
5.71
7.57
1.6
2.1
14.3
12.3
%
—
9
14
350
2800
1.62
7.34
5.1
4.2
6.7
6.5
mmol/l
0.49
330
2595
187
1287
1.66
7.21
2.6
2.9
833.8
1064.4
ng/l
0.57
155
1082
95
538
1.91
7.13
2.9
2.1
6.2
6.3
umol/l
0.02
85
455
202
1422
1.64
7.11
5.2
3.8
13.7
6.6
mg/mmol
0.93
132
808
67
336
2.12
7.04
1.7
1.5
—
—
—
0
0
120
735
1.80
7.02
2.1
1.8
—
—
—
0
0
126
789
1.76
6.82
3.7
2.6
1.4
1.2
e6/l
0.29
82
421
551
5057
2.46
6.73
21.1
12.7
21.6
21.1
mg/l
0.11
461
3938
96
560
1.85
6.56
9.4
4.0
1.1
1.0
mmol/l
0.47
89
505
317
2548
1.53
5.98
4.5
3.8
0.0
0.0
estimate
0.00
57
481
266
2073
1.52
5.72
2.2
2.0
98.2
98.8
pmol/l
0.06
127
999
12
25
4.88
5.51
1.6
2.2
—
—
—
0
0
203
1503
1.54
5.49
2.3
2.1
120.2
149.0
u/l
1.15
191
1414
95
583
1.75
5.46
2.0
2.0
—
—
—
0
0
567
5334
2.85
5.45
22.4
14.6
71.7
69.1
umol/l
1.01
567
5334
524
4784
1.89
5.45
17.3
11.6
80.7
81.4
ml/min/173m2
0.29
457
3885
69
387
1.89
5.31
4.5
2.8
2.0
2.3
mmol/l
0.27
55
319
289
2321
1.48
5.21
2.5
2.3
82.3
78.4
nmol/l
1.40
248
2083
98
619
1.70
5.07
8.0
5.9
—
—
—
0
0
110
721
1.65
4.94
4.0
2.8
3.3
4.5
e6/l
0.87
67
353
133
921
1.57
4.76
1.8
1.7
1156.4
1248.9
nmol/l
0.54
103
682
20
70
2.92
4.53
1.9
1.4
—
—
—
0
0
39
189
2.14
4.51
5.0
2.8
24.2
24.6
mmol/l
0.35
34
169
78
480
1.72
4.43
4.5
6.1
0.4
1.5
mmol/l
1.35
57
382
84
528
1.69
4.42
2.0
1.9
—
—
—
0
0
161
1181
1.50
4.40
1.7
1.6
0.9
0.9
mg/l
0.00
127
892
37
178
2.15
4.37
1.6
2.4
1.8
1.5
g/l
0.85
31
160
436
3870
1.49
4.28
5.7
4.2
13.4
12.1
mm/h
1.14
405
3569
16
51
3.20
4.23
1.3
1.5
—
—
—
0
0
78
489
1.69
4.14
2.5
2.1
362.7
372.1
nmol/l
0.13
70
455
578
5592
3.19
4.07
30.5
19.2
130.4
131.9
g/l
2.18
571
5515
564
5361
2.33
4.04
14.2
9.9
23.9
23.3
u/l
0.39
548
5171
59
344
1.80
4.04
1.7
1.7
—
—
—
0
0
84
542
1.64
4.00
21.7
21.7
1.3
1.2
inr
0.26
14
79
473
4291
1.53
3.98
5.0
4.5
14.9
14.7
pmol/l
0.52
440
3931
13
38
3.48
3.92
1.4
1.0
—
—
—
0
0
525
4887
1.70
3.87
6.2
5.4
1.8
2.1
mu/l
0.68
493
4506
80
514
1.64
3.87
2.0
1.8
—
—
—
0
0
45
245
1.91
3.82
6.6
3.2
1.4
1.9
mmol/l
0.35
39
189
47
260
1.88
3.81
6.7
3.3
5.2
5.1
kpa
0.12
42
244
33
162
2.10
3.73
1.2
1.4
376.6
306.5
ug/g
0.82
20
93
90
601
1.59
3.73
4.1
2.2
22.6
21.5
%
0.34
73
503
227
1825
1.40
3.69
4.3
3.2
2.4
2.4
mmol/l
0.12
191
1596
12
35
3.48
3.63
1.3
1.6
—
—
—
0
0
123
886
1.49
3.61
3.8
3.7
68.9
271.2
ng/l
1.53
88
643
176
1360
1.42
3.57
4.9
4.1
0.0
0.0
estimate
0.50
60
486
47
266
1.83
3.56
1.7
1.6
—
—
—
0
0
135
994
1.47
3.55
1.6
1.5
—
—
—
0
0
102
709
1.53
3.54
3.8
2.1
12.3
13.1
umol/l
0.51
90
647
35
180
2.00
3.51
2.5
1.8
—
—
—
0
0
90
610
1.56
3.50
4.6
4.3
34.1
33.6
%
0.12
61
391
33
167
2.03
3.46
2.6
1.7
—
—
—
0
0
76
500
1.60
3.35
1.8
1.5
1.4
1.4
%
0.10
66
443
16
59
2.76
3.34
1.3
1.4
—
—
—
0
0
94
651
1.53
3.32
3.8
2.1
2.2
2.4
g/l
4.22
83
599
157
1204
1.41
3.30
2.8
2.4
5160.1
6743.0
umol/l
0.18
136
1042
77
511
1.58
3.28
1.9
1.8
—
—
—
0
0
371
3271
1.36
3.24
3.2
3.2
—
—
—
0
0
498
4625
1.51
3.17
6.8
5.4
39.3
39.1
mmol/mol
0.16
466
4278
13
44
3.00
3.15
1.2
1.1
—
—
—
0
0
33
174
1.95
3.11
1.2
1.1
—
—
—
0
0
237
1961
1.35
3.09
4.9
4.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
119
2.15
3.08
2.3
2.6
0.4
0.4
u/ml
0.08
14
74
6
8
7.56
3.06
1.0
1.0
—
—
—
0
0
25
120
2.13
3.03
1.6
1.5
—
—
—
0
0
14
51
2.79
3.00
1.1
1.5
—
—
—
0
0
5
5
10.07
2.98
2.8
3.4
—
—
—
0
0
152
1179
1.39
2.96
1.5
1.5
22.7
22.3
nmol/l
0.10
132
1000
23
108
2.18
2.94
4.0
3.1
24.3
25.2
mmol/l
0.32
17
94
17
70
2.47
2.90
1.2
1.5
—
—
—
0
0
12
41
2.97
2.87
1.2
1.5
—
—
—
0
0
32
173
1.90
2.83
1.2
1.1
—
—
—
0
0
216
1783
1.33
2.81
3.8
3.5
17.1
29.4
ng/l
1.87
140
1152
25
125
2.04
2.75
1.3
1.2
—
—
—
0
0
277
2376
1.31
2.72
3.4
2.8
107.7
84.8
ug/l
1.27
249
2190
22
105
2.14
2.72
1.4
1.6
—
—
—
0
0
157
1241
1.36
2.70
2.8
2.1
3.1
3.0
mg/l
0.06
130
1050
10
32
3.16
2.65
1.3
1.8
—
—
—
0
0
492
4602
1.43
2.59
19.4
13.8
38.5
39.1
%
0.84
348
3330
15
62
2.46
2.56
1.5
1.6
—
—
—
0
0
22
108
2.08
2.55
1.4
1.7
—
—
—
0
0
31
174
1.83
2.47
1.5
1.2
18.3
2.3
u/ml
—
6
20
53
346
1.58
2.45
1.2
1.3
—
44.3
—
0
15
10
34
2.97
2.42
1.7
1.4
—
—
—
0
0
20
98
2.08
2.34
1.5
1.6
—
—
—
0
0
36
216
1.71
2.31
5.3
7.3
23.8
24.5
mmol/l
0.56
30
199
31
178
1.78
2.31
1.5
1.2
2.5
9.2
u/ml
—
8
31
365
3291
1.29
2.30
4.0
2.9
52.4
42.1
u/l
1.10
342
3067
142
1131
1.34
2.30
4.8
4.1
1.0
1.0
kg/l
0.83
24
163
17
79
2.19
2.27
1.4
1.2
—
—
—
0
0
506
4786
1.41
2.22
4.4
3.8
1.3
1.2
mmol/l
1.77
463
4381
157
1275
1.32
2.21
1.2
1.3
0.7
1.8
u/ml
1.77
30
340
13
54
2.44
2.21
1.2
1.1
39.1
55.0
u/l
—
8
40
8
24
3.36
2.18
1.0
1.0
—
—
—
0
0
17
81
2.13
2.14
1.4
1.3
—
—
—
0
0
124
978
1.34
2.14
3.3
2.6
2.5
2.5
mmol/l
0.49
106
864
46
303
1.56
2.08
1.6
1.3
—
—
—
0
0
5
10
5.03
2.07
1.6
1.1
—
—
—
0
0
61
428
1.47
2.06
2.6
2.9
253.0
56.1
u/ml
0.44
61
409
65
462
1.46
2.06
3.0
2.2
27.8
33.2
u/l
1.04
54
385
13
56
2.35
2.06
1.0
1.1
—
—
—
0
0
56
387
1.49
2.04
2.4
2.4
24.0
17.0
au/ml
—
5
17
23
126
1.86
2.01
1.2
1.2
—
—
—
0
0
52
356
1.51
1.98
2.5
2.9
210.2
185.8
ng/l
0.13
46
331
59
415
1.47
1.98
5.5
3.1
102.7
78.0
ng/l
1.20
52
368
20
105
1.94
1.98
2.0
2.3
—
—
—
0
0
5
11
4.57
1.94
1.2
1.0
—
—
—
0
0
40
260
1.58
1.92
1.6
1.7
—
—
—
0
0
132
1070
1.30
1.87
1.6
1.7
459.4
30717178.9
pmol/l
1.31
103
879
9
34
2.67
1.87
1.0
1.3
—
—
—
0
0
7
23
3.07
1.80
2.6
1.3
—
—
—
0
0
52
364
1.47
1.80
2.1
2.3
2.2
4.5
ug/l
3.56
45
317
191
1630
1.25
1.79
3.9
2.8
30.7
29.5
u/l
0.31
182
1557
15
74
2.05
1.76
1.3
1.2
—
—
—
0
0
33
210
1.61
1.75
2.4
2.0
2153.0
4103.5
u/l
0.42
12
91
8
30
2.69
1.73
1.1
1.2
—
—
—
0
0
15
75
2.03
1.71
1.5
1.6
—
—
—
0
0
40
269
1.52
1.68
3.1
2.6
124.0
128.9
g/l
0.87
40
263
33
214
1.57
1.63
3.5
2.8
25.3
25.5
mmol/l
0.13
33
209
18
98
1.86
1.63
3.2
1.9
121.6
129.3
g/l
—
10
72
51
365
1.44
1.60
3.9
3.3
4.5
4.6
pmol/l
0.03
43
320
7
26
2.71
1.58
1.0
1.2
—
—
—
0
0
19
107
1.80
1.56
4.3
3.7
56.5
58.3
%
0.23
19
107
22
130
1.72
1.55
1.9
1.8
185.1
198.0
ug/l
0.07
22
114
514
4934
1.34
1.53
5.6
4.4
5.9
5.8
mmol/l
0.79
468
4512
5
15
3.35
1.52
1.2
1.1
—
—
—
0
0
5
15
3.35
1.52
1.2
1.1
—
—
—
0
0
56
412
1.40
1.51
2.0
2.5
57.0
69.4
ml/min/173m2
0.84
15
168
31
202
1.56
1.51
6.2
1.7
—
—
—
0
0
28
179
1.59
1.48
1.6
1.3
304.3
251.8
miu/ml
0.30
11
82
31
204
1.55
1.46
1.7
2.1
34.1
39.9
u/l
0.72
25
183
15
80
1.90
1.46
1.0
1.0
2.7
1.6
u/ml
—
8
40
6
23
2.62
1.37
1.2
1.2
—
—
—
0
0
6
23
2.62
1.37
1.2
1.2
—
—
—
0
0
64
491
1.34
1.36
3.4
3.3
—
—
—
0
0
31
208
1.52
1.35
2.4
2.1
1.3
1.1
%
0.42
31
208
18
105
1.74
1.34
4.3
3.3
3.5
4.3
e9/l
1.36
18
105
9
42
2.16
1.34
3.0
2.2
—
—
—
0
0
51
379
1.38
1.32
1.6
2.8
64.5
67.8
g/l
1.53
43
347
33
227
1.48
1.29
2.7
2.6
0.3
0.2
e6/l
0.23
33
218
12
62
1.96
1.28
1.8
1.3
—
—
—
0
0
26
171
1.54
1.25
1.3
1.9
—
—
—
0
0
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
8
36
2.24
1.24
1.3
1.4
—
—
—
0
0
12
63
1.92
1.23
1.8
1.3
—
—
—
0
0
12
63
1.92
1.23
1.8
1.3
—
—
—
0
0
11
56
1.98
1.22
2.1
1.9
65.3
57.7
%
—
6
37
5
19
2.65
1.22
1.2
1.4
—
—
—
0
0
27
181
1.52
1.20
6.4
1.4
1.1
1.2
g/l
0.93
27
171
6
26
2.32
1.19
1.2
1.4
—
—
—
0
0
6
26
2.32
1.19
1.2
1.4
—
—
—
0
0
15
87
1.74
1.16
1.0
1.2
2.2
6.3
u/ml
—
9
32
515
4985
1.27
1.11
4.9
4.2
1.5
1.6
mmol/l
1.47
471
4603
36
261
1.40
1.10
1.6
1.4
—
—
—
0
0
12
66
1.84
1.09
1.8
1.3
—
—
—
0
0
12
66
1.84
1.09
1.8
1.2
—
—
—
0
0
12
66
1.84
1.09
1.8
1.3
—
—
—
0
0
7
33
2.13
1.06
1.4
1.1
—
—
—
0
0
22
146
1.53
1.04
1.9
1.8
93.3
97.9
%
0.42
22
137
9
46
1.97
1.04
1.2
1.3
—
—
—
0
0
5
22
2.28
1.03
1.2
1.0
—
—
—
0
0
7
34
2.07
1.03
1.1
1.2
—
—
—
0
0
7
36
1.96
0.97
1.0
1.0
—
—
—
0
0
525
5108
1.26
0.97
5.6
4.8
2.7
2.8
mmol/l
1.54
482
4712
25
175
1.45
0.94
6.8
1.5
0.2
0.2
g/l
0.19
25
167
36
270
1.36
0.93
1.4
1.5
—
—
—
0
0
9
52
1.74
0.92
1.7
1.7
—
—
—
0
0
38
288
1.34
0.92
1.1
1.0
—
—
—
0
0
6
28
2.15
0.91
1.2
1.4
—
—
—
0
0
515
5013
1.22
0.85
5.1
4.3
4.7
4.8
mmol/l
1.55
476
4648
20
137
1.48
0.85
1.2
1.3
—
—
—
0
0
6
31
1.94
0.84
1.8
1.4
14.7
26.3
ug/l
—
6
31
8
45
1.79
0.84
1.0
1.0
—
—
—
0
0
19
129
1.49
0.84
2.2
1.4
—
—
—
0
0
6
109
0.55
0.73
2.0
1.6
—
—
—
0
0
7
40
1.76
0.71
1.0
2.0
—
—
—
0
0
116
1030
1.16
0.70
1.3
1.3
21.1
30.9
iu/ml
0.97
28
338
16
110
1.47
0.69
1.8
1.3
—
—
—
0
0
19
136
1.41
0.67
1.1
1.1
—
—
—
0
0
153
1392
1.13
0.65
1.8
1.6
1.4
1.3
mmol/l
0.35
132
1181
14
95
1.49
0.64
4.1
2.3
15.9
16.0
%
—
8
45
13
87
1.51
0.63
1.0
1.1
1.3
1.9
u/ml
—
7
26
0
20
0.00
0.60
0.0
1.0
—
111.1
—
0
9
21
157
1.35
0.60
1.4
1.6
—
—
—
0
0
10
64
1.57
0.59
1.0
1.1
—
—
—
0
0
50
421
1.21
0.58
4.8
3.5
1.2
1.2
mmol/l
0.39
42
364
8
54
1.49
0.57
1.0
1.1
—
—
—
0
0
5
90
0.55
0.56
1.6
1.5
—
—
—
0
0
13
91
1.44
0.53
1.8
1.2
—
—
—
0
0
13
91
1.44
0.53
1.8
1.2
—
—
—
0
0
9
62
1.46
0.53
1.0
1.1
—
—
—
0
0
6
39
1.54
0.53
1.2
1.7
—
—
—
0
0
10
66
1.52
0.53
4.7
5.5
323.0
393.9
umol/l
—
10
59
52
445
1.18
0.52
1.1
1.2
106.5
157.8
iu/ml
0.44
14
190
7
45
1.56
0.49
2.6
3.6
—
—
—
0
0
19
146
1.31
0.47
1.5
1.2
843.5
457.0
mg/l
0.47
19
135
438
4272
1.10
0.44
23.0
15.6
13.7
13.6
%
0.19
429
4187
22
176
1.26
0.42
1.4
2.2
9.2
10.2
g/l
0.31
16
156
19
149
1.28
0.42
1.9
1.6
—
188.6
—
0
7
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
102.2
—
0
15
0
18
0.00
0.40
0.0
1.4
—
5.9
—
0
12
21
169
1.25
0.39
1.4
2.2
3.2
3.2
g/l
0.03
15
143
9
124
0.72
0.35
1.3
1.5
—
—
—
0
0
22
181
1.22
0.35
1.4
2.2
3.5
3.7
g/l
0.34
15
141
23
275
0.83
0.34
1.5
1.5
—
—
—
0
0
22
182
1.22
0.33
1.4
2.1
—
—
—
0
0
22
182
1.22
0.33
1.4
2.1
7.9
7.7
g/l
0.19
15
145
55
494
1.13
0.32
3.5
3.7
3.9
9.5
ug/l
2.37
41
394
7
57
1.23
0.29
1.1
1.1
—
—
—
0
0
22
186
1.19
0.28
1.5
1.7
—
—
—
0
0
10
77
1.30
0.26
1.1
1.1
—
—
—
0
0
9
76
1.19
0.24
2.1
1.7
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
118.5
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
14
117
1.20
0.20
3.1
1.8
9281.0
17751.9
e6/l
0.63
14
82
7
62
1.13
0.17
1.1
1.1
—
—
—
0
0
40
430
0.93
0.15
1.7
1.7
—
—
—
0
0
15
170
0.88
0.14
1.7
1.5
—
—
—
0
0
19
170
1.12
0.13
2.8
1.9
2.7
4.3
iu/l
—
8
56
17
151
1.13
0.13
1.1
1.2
—
—
—
0
0
14
159
0.88
0.13
1.4
1.4
—
—
—
0
0
14
159
0.88
0.13
1.4
1.4
—
—
—
0
0
105
1015
1.04
0.12
1.3
1.3
2.4
10.9
u/ml
4.40
30
387
14
158
0.88
0.12
1.4
1.4
—
—
—
0
0
14
158
0.88
0.12
1.4
1.4
—
—
—
0
0
19
208
0.91
0.10
1.2
1.8
1.8
2.4
mg/l
0.35
14
152
10
87
1.15
0.09
1.4
1.6
—
—
—
0
0
17
185
0.92
0.08
1.5
1.5
—
—
—
0
0
7
65
1.08
0.08
5.0
2.3
13.1
13.4
%
—
7
65
32
322
0.99
0.00
1.2
1.3
34.3
30.8
iu/l
0.20
26
286
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
77.3
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
10
100
1.00
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
5
59
0.85
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.7
—
0.6
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.1
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_VULVAL_HSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VULVAL_HSIL | 1.464 [1.23, 1.74] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.114 |
During the follow-up period (1.1.1998 — 31.12.2019), 378 out of 2373 females with N14_VULVAL_HSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VULVAL_HSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | No data |
| 5 | 0.772% | No data |
| 10 | 2.04% | No data |
| 15 | 3.618% | No data |
| 20 | 6.301% | No data |
Relationships between endpoints
↥Index endpoint: N14_VULVAL_HSIL – HSIL lesion of the vulva
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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