No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditionsNone |
293218 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
519 |
4. Check minimum number of eventsNone |
519 |
5. Include endpointsNone |
519 |
6. Filter based on genotype QC (FinnGen only) |
505 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
HSIL lesion of the vagina
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the vagina
- HSIL lesion of the cervix uteri, vagina or vulva
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2714 | 2714 | - |
| Only index persons | 2571 | 2571 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.09 | 0.09 | - |
| Median age at first event (years) | |||
| Whole population | - | 49.94 | - |
| Only index persons | - | 48.76 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 505 | 505 | - |
| Unadjusted period prevalence (%) | 0.18 | 0.18 | - |
| Median age at first event (years) | 51.16 | 51.16 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 519
- Matched controls
- 5190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
24.3
315.5
356
428
LEB00
NOMESCO Finland
Biopsy of vagina
126.9
307.7
273
45
ULA02
NOMESCO Finland
Kolposcopy
42.3
307.7
411
428
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
+∞
307.7
291
*
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
633.2
284.2
257
8
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
+∞
276.6
240
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
17.1
232.1
253
273
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
13.1
201.5
313
540
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
16.0
165.4
163
144
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
+∞
154.0
140
*
N87.0
ICD-10 Finland
Mild cervical dysplasia
16.0
114.4
106
82
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
16.7
113.2
102
75
A63.0
ICD-10 Finland
Anogenital (venereal) warts
15.2
112.2
107
87
LDA10
NOMESCO Finland
Curettage of cervix uteri
10.5
107.1
137
172
N87.1
ICD-10 Finland
Moderate cervical dysplasia
16.4
103.2
93
68
N89.0
ICD-10 Finland
Mild vaginal dysplasia
174.2
96.9
99
7
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
14.1
84.2
82
68
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
20.7
81.6
64
35
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
15.9
73.7
66
47
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
24.0
68.3
50
23
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
233.9
42.6
43
*
ZXC10
NOMESCO Finland
Use of laser
10.6
40.6
46
47
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
66.2
32.5
37
6
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
35.0
30.4
39
12
LEB10
NOMESCO Finland
Excision of lesion of vagina
36.1
29.1
37
11
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.6
24.2
268
1531
N90.0
ICD-10 Finland
Mild vulvar dysplasia
37.4
20.0
25
7
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
18.9
18
*
D06BB10
ATC
imiquimod; topical
4.2
18.6
53
138
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
14.6
17.5
29
21
6230B
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE MODERATA]
+∞
16.8
16
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.1
13.7
370
2786
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
35.1
13.6
17
5
L04AX01
ATC
azathioprine; systemic
3.9
12.0
36
97
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
15.0
10.1
16
11
LEC00
NOMESCO Finland
Partial excision of vagina
56.1
9.7
11
*
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
30.6
9.4
12
*
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
22.2
9.4
13
6
D06BB04
ATC
podophyllotoxin; topical
3.0
9.2
41
143
L04AA06
ATC
mycophenolic acid; systemic
7.2
9.1
21
30
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.1
8.4
94
504
6230C
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE GRAVIS]
+∞
8.4
8
*
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
33.9
8.1
10
*
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
22.4
8.0
11
5
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.9
206
1440
C52.91
ICD-10 Finland
Squamous cell carcinoma of the vagina
45.7
7.7
9
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.2
7.6
64
306
G01AA10
ATC
clindamycin; vaginal
1.8
7.6
130
803
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.1
7.3
13
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
7.3
69
346
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.4
7.2
26
80
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.1
7.2
30
101
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.9
7.1
21
56
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
14.0
6.9
11
8
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
40.6
6.8
8
*
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
22.8
6.7
9
*
L01BA01
ATC
methotrexate; systemic
3.1
6.6
28
95
8326
FHL
Batch conization
12.5
6.6
11
9
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
6.5
29
102
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
6.3
48
221
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.2
171
1196
C10AC01
ATC
colestyramine; oral
3.5
6.2
21
62
C539, 6666, 0
ICD-O-3
6.4
6.2
15
24
L04AA01
ATC
[U] ciclosporin
6.4
6.2
15
24
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
6.2
69
369
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.1
238
1808
127
Kela drug reimbursment
Transplant complication
6.8
6.1
14
21
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
6.0
54
265
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
27
22.67
73.31
4.4
1.5
—
—
—
0
0
303
1197
4.68
66.92
3.2
1.4
—
—
—
0
0
131
275
6.03
62.35
3.4
1.4
—
—
—
0
0
70
329
2.30
8.70
1.7
1.6
—
—
—
0
0
58
257
2.41
8.23
1.7
1.5
—
—
—
0
0
270
2075
1.63
6.87
2.7
2.4
—
—
—
0
0
262
2011
1.61
6.61
2.9
2.3
80.91
78.34
nmol/l
0.70
240
1811
39
166
2.46
6.05
4.5
1.7
—
—
—
0
0
168
1185
1.62
5.84
3.5
2.9
6.64
6.87
mmol/l
0.32
135
1000
142
968
1.64
5.63
1.5
1.5
20.53
22.19
nmol/l
0.59
121
828
22
73
3.10
5.44
7.8
5.4
691.80
181.88
iu/ml
—
5
8
16
43
3.81
5.40
1.4
1.1
45.60
68.67
u/ml
—
5
6
33
139
2.47
5.25
1.8
2.4
1.52
1.54
g/l
0.03
27
123
66
372
1.89
5.05
5.8
4.4
249.88
239.29
u/l
0.28
60
355
224
1740
1.51
4.88
6.6
4.1
35.75
36.08
g/l
0.38
205
1624
32
139
2.39
4.79
1.6
1.2
3.87
1.98
u/ml
—
10
16
92
583
1.70
4.76
2.2
1.8
—
—
—
0
0
387
3384
1.56
4.66
5.6
4.1
13.26
11.54
mm/h
1.62
358
3134
273
2224
1.48
4.62
4.6
3.5
0.00
0.01
estimate
0.80
47
410
32
143
2.32
4.50
1.6
1.2
2.64
12.75
u/ml
0.91
12
29
262
2126
1.47
4.47
8.6
5.7
28.55
29.06
%
0.34
250
1989
259
2100
1.47
4.42
8.5
5.5
56.93
56.75
%
0.09
248
1959
142
1022
1.54
4.34
2.4
2.1
—
—
—
0
0
157
1155
1.52
4.33
4.1
3.5
12.29
5.59
mg/mmol
0.59
82
663
158
1166
1.51
4.29
5.0
3.8
0.00
0.00
estimate
0.80
45
421
87
559
1.67
4.26
1.7
2.0
—
—
—
0
0
268
2206
1.44
4.12
5.8
4.8
0.00
0.00
estimate
0.50
46
418
12
26
4.70
4.08
1.7
1.7
633.75
792.50
e6/l
0.44
12
26
79
505
1.67
3.95
1.7
1.9
—
—
—
0
0
264
2200
1.41
3.62
4.6
3.5
0.00
0.00
estimate
-0.00
50
446
102
711
1.54
3.56
1.8
1.7
1170.87
1219.35
nmol/l
0.22
82
530
17
63
2.76
3.52
1.3
1.3
—
—
—
0
0
15
52
2.94
3.49
1.1
1.1
—
—
—
0
0
379
3379
1.45
3.46
10.4
6.9
74.08
76.86
u/l
0.89
367
3158
79
523
1.60
3.44
3.9
4.1
33.05
33.06
%
0.00
56
344
229
1874
1.40
3.43
7.1
4.9
1.22
1.22
mmol/l
0.05
208
1702
138
1033
1.46
3.40
3.0
2.3
309.44
6710.66
umol/l
4.99
124
906
44
252
1.82
3.24
12.1
7.0
10.41
8.26
mmol/l
1.55
44
239
208
1705
1.37
2.98
2.0
1.9
105.34
99.87
pmol/l
0.61
105
832
189
1527
1.37
2.96
3.4
3.3
2.37
2.36
mmol/l
0.63
156
1351
75
509
1.55
2.94
8.4
5.5
—
—
—
0
0
298
2587
1.36
2.93
11.8
8.6
3.91
3.95
e9/l
0.13
272
2284
16
64
2.55
2.90
2.2
3.0
2.03
1.29
%
0.31
16
58
9
22
4.14
2.89
1.4
1.8
—
—
—
0
0
60
388
1.62
2.88
2.0
1.7
—
—
—
0
0
60
389
1.61
2.85
2.0
1.8
—
—
—
0
0
45
272
1.72
2.79
1.7
1.5
—
—
—
0
0
125
951
1.41
2.77
5.3
3.8
1.01
1.02
kg/l
0.80
12
127
145
1132
1.39
2.77
1.4
1.3
1.70
2.04
u/ml
0.11
39
310
52
330
1.64
2.70
4.8
2.9
127.30
75.07
ng/l
2.14
47
297
7
15
4.71
2.60
2.1
1.1
—
—
—
0
0
7
15
4.71
2.60
2.1
1.1
—
—
—
0
0
11
36
3.10
2.58
1.2
1.3
—
—
—
0
0
18
81
2.27
2.57
1.8
1.7
—
—
—
0
0
5
7
7.20
2.55
1.6
1.0
—
—
—
0
0
29
159
1.87
2.49
2.3
1.8
—
—
—
0
0
181
1485
1.34
2.49
3.4
3.1
22.76
26.78
ng/l
0.30
102
903
244
2090
1.32
2.47
9.0
5.6
1.22
1.22
mmol/l
0.07
210
1768
8
21
3.85
2.47
2.0
1.2
—
—
—
0
0
8
21
3.85
2.47
2.0
1.2
—
—
—
0
0
43
267
1.67
2.44
2.3
1.5
—
—
—
0
0
133
1050
1.36
2.34
3.1
2.2
2.68
2.99
mg/l
1.04
119
894
155
1255
1.34
2.30
1.9
2.0
110.11
129.50
u/l
0.86
146
1185
10
34
2.98
2.29
1.9
1.6
0.97
1.04
g/l
—
10
34
27
149
1.86
2.29
2.1
1.7
—
—
—
0
0
52
345
1.56
2.28
1.2
1.3
123.45
150.88
u/ml
0.26
47
324
126
992
1.36
2.25
3.1
2.9
898.09
987.23
ng/l
0.18
102
824
102
779
1.39
2.20
2.9
2.6
2.46
2.44
mmol/l
0.64
85
686
19
95
2.04
2.13
1.8
1.2
—
—
—
0
0
32
191
1.72
2.12
1.8
1.6
—
—
—
0
0
10
37
2.74
2.08
2.9
2.6
54.60
51.41
%
—
10
32
5
11
4.58
1.94
1.6
2.2
—
—
—
0
0
7
22
3.21
1.88
1.7
3.3
—
—
—
0
0
469
4486
1.47
1.85
17.7
12.0
16.56
20.18
mg/l
2.38
370
3454
268
2383
1.26
1.84
5.4
4.1
6.57
6.46
mmol/l
0.32
256
2212
6
17
3.56
1.84
1.2
1.2
—
—
—
0
0
21
116
1.84
1.81
1.7
1.2
51.55
43.60
u/ml
—
6
10
45
306
1.52
1.80
6.5
2.8
1.16
2.25
mmol/l
1.61
39
256
25
147
1.74
1.77
1.7
1.6
0.00
0.14
iu/ml
—
5
18
127
1035
1.30
1.77
1.7
1.7
0.97
0.91
mg/l
0.17
102
791
52
367
1.46
1.75
6.6
7.2
0.87
1.42
mmol/l
0.59
42
304
8
30
2.69
1.73
2.4
1.7
—
—
—
0
0
110
882
1.31
1.72
1.6
1.6
45544983.12
27875959.00
pmol/l
0.15
101
739
201
1744
1.25
1.67
14.6
10.8
1.17
1.13
inr
0.27
59
540
82
633
1.35
1.66
3.9
2.4
1.24
1.23
e6/l
0.01
52
326
472
4538
1.44
1.62
17.5
12.9
139.64
139.74
mmol/l
0.31
464
4413
197
1713
1.24
1.59
4.8
3.6
—
—
—
0
0
6
20
3.02
1.58
1.0
1.1
—
—
—
0
0
19
107
1.81
1.56
3.6
2.2
1.99
1.38
mg/l
1.32
19
97
12
57
2.13
1.56
1.1
1.1
—
—
—
0
0
8
33
2.45
1.54
2.5
1.4
—
—
—
0
0
8
33
2.45
1.54
2.5
1.4
—
—
—
0
0
8
33
2.45
1.54
2.5
1.4
—
—
—
0
0
472
4548
1.42
1.49
17.8
13.0
3.93
3.92
mmol/l
0.38
462
4410
61
458
1.38
1.48
5.9
2.2
8.36
6.35
umol/l
0.31
56
389
22
133
1.68
1.45
1.2
1.2
—
—
—
0
0
6
22
2.75
1.44
1.2
1.2
—
—
—
0
0
6
22
2.75
1.44
1.2
1.4
5.42
5.49
mmol/l
—
6
22
129
1085
1.25
1.38
4.3
2.7
0.33
0.43
e6/l
0.44
102
806
487
4728
1.49
1.38
18.9
13.6
71.55
68.09
umol/l
1.14
487
4728
29
192
1.54
1.35
2.0
2.2
42.92
39.27
u/l
0.45
24
174
0
38
0.00
1.35
0.0
1.1
—
1.13
—
0
20
8
34
2.37
1.29
2.4
1.6
—
—
—
0
0
10
48
2.10
1.28
1.9
1.6
5.72
84.97
u/ml
—
10
48
72
571
1.30
1.24
4.1
2.2
2.22
2.45
g/l
2.51
67
524
49
367
1.37
1.23
2.4
2.3
67.32
69.97
ml/min/173m2
0.12
19
148
488
4752
1.45
1.21
13.3
9.8
22.93
23.68
u/l
0.65
472
4593
23
149
1.57
1.19
1.3
1.2
—
—
—
0
0
23
149
1.57
1.19
1.3
1.2
—
—
—
0
0
21
133
1.60
1.19
1.0
1.1
—
—
—
0
0
12
64
1.90
1.19
2.1
1.5
—
—
—
0
0
12
64
1.90
1.19
2.1
1.5
—
—
—
0
0
16
95
1.71
1.15
3.3
2.4
—
—
—
0
0
54
417
1.33
1.13
2.3
2.1
360.82
372.24
nmol/l
0.16
49
392
7
30
2.35
1.12
1.6
1.2
—
—
—
0
0
110
931
1.23
1.12
1.4
1.3
5.97
12.09
u/ml
0.73
41
370
21
136
1.57
1.10
1.1
1.3
—
—
—
0
0
11
59
1.88
1.08
2.5
1.3
—
—
—
0
0
29
203
1.45
1.08
4.5
7.2
24.67
24.98
mmol/l
0.23
29
198
5
22
2.28
1.03
2.4
1.4
—
—
—
0
0
5
22
2.28
1.03
2.4
1.4
—
—
—
0
0
11
60
1.85
1.03
2.5
1.3
—
—
—
0
0
11
60
1.85
1.03
2.5
1.3
—
—
—
0
0
7
34
2.07
1.03
1.0
1.0
—
—
—
0
0
65
524
1.27
1.01
4.3
2.3
26.87
22.27
%
1.02
58
443
13
76
1.73
0.99
1.3
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
76
1.73
0.99
2.8
3.0
0.28
0.40
u/ml
—
7
41
13
76
1.73
0.99
1.9
1.2
—
—
—
0
0
13
76
1.73
0.99
1.3
1.2
—
—
—
0
0
26
183
1.44
0.95
1.3
1.3
202.81
245.46
miu/ml
0.26
16
96
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
11
62
1.79
0.95
2.5
1.3
—
—
—
0
0
11
62
1.79
0.95
2.5
1.3
—
—
—
0
0
11
62
1.79
0.95
2.5
1.3
—
—
—
0
0
11
62
1.79
0.95
1.4
1.5
7.74
7.05
mmol/l
0.32
11
51
74
612
1.24
0.94
4.2
2.2
14.02
13.31
umol/l
0.25
69
566
51
403
1.29
0.93
3.3
3.1
—
—
—
0
0
6
28
2.16
0.91
1.2
1.1
—
—
—
0
0
23
160
1.46
0.90
3.3
2.0
1.37
1.11
%
0.37
23
160
505
4973
1.57
0.89
25.0
18.1
264.71
265.13
e9/l
0.05
497
4858
8
42
1.92
0.89
1.6
1.6
—
—
—
0
0
8
42
1.92
0.89
1.6
1.6
—
—
—
0
0
450
4363
1.24
0.89
4.6
4.2
5.74
5.75
mmol/l
0.04
417
4026
70
580
1.24
0.88
4.4
2.5
3.05
4.71
e6/l
0.99
40
277
243
2247
1.15
0.87
8.3
5.5
9.22
9.85
umol/l
0.76
235
2117
6
30
2.01
0.87
1.2
1.4
1.50
1.61
g/l
—
6
30
505
4975
1.56
0.86
25.0
18.1
4.37
4.42
e12/l
1.64
496
4847
466
4538
1.26
0.86
5.0
4.6
2.87
2.90
mmol/l
0.34
430
4217
234
2162
1.15
0.84
3.3
2.8
100.61
81.16
ug/l
1.07
220
2005
505
4977
1.54
0.83
25.1
18.2
131.53
132.57
g/l
1.14
499
4910
112
979
1.18
0.83
1.6
1.5
—
—
—
0
0
37
285
1.32
0.83
2.2
1.4
—
—
—
0
0
151
1354
1.16
0.82
4.2
2.3
63.03
55.80
u/l
0.41
143
1255
8
47
1.71
0.81
1.1
1.0
1.86
1.43
g/l
—
8
42
8
47
1.71
0.81
1.4
1.6
—
—
—
0
0
11
66
1.68
0.79
2.1
1.6
—
—
—
0
0
6
34
1.77
0.76
1.2
1.4
—
—
—
0
0
504
4970
1.49
0.76
25.0
18.1
39.57
39.61
%
0.06
482
4693
5
25
2.01
0.73
1.0
1.1
—
—
—
0
0
19
134
1.43
0.72
1.5
1.4
259.66
311.26
ug/g
0.37
12
73
9
57
1.59
0.71
1.0
1.2
—
—
—
0
0
5
26
1.93
0.71
1.2
1.1
—
—
—
0
0
5
26
1.93
0.71
1.0
1.6
127.68
28.07
ug/l
—
5
26
36
284
1.29
0.70
3.1
2.8
68.38
67.82
g/l
0.15
29
263
14
93
1.52
0.70
1.9
1.6
—
—
—
0
0
59
495
1.22
0.69
1.7
1.5
1.35
1.30
%
0.35
53
439
11
69
1.61
0.69
5.0
3.2
40.87
41.48
u/ml
0.01
11
69
106
938
1.16
0.68
1.3
1.3
22.03
31.73
iu/ml
0.77
35
328
35
277
1.28
0.67
1.1
1.0
—
—
—
0
0
35
279
1.27
0.64
2.6
2.3
2.38
4.98
ug/l
2.83
27
250
5
29
1.73
0.64
1.0
1.2
34.00
27.94
nmol/l
—
5
22
0
20
0.00
0.60
0.0
1.1
—
100.00
—
0
11
0
20
0.00
0.60
0.0
1.2
—
8.46
—
0
20
0
20
0.00
0.60
0.0
1.0
—
95.36
—
0
11
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
20
0.00
0.60
0.0
1.0
—
126.85
—
0
20
457
4470
1.19
0.60
4.6
4.2
4.85
4.89
mmol/l
0.52
424
4179
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
107.24
—
0
21
14
97
1.46
0.59
2.3
1.3
—
—
—
0
0
11
72
1.54
0.59
1.1
1.0
—
—
—
0
0
438
4273
1.16
0.58
13.9
10.9
83.21
83.97
ml/min/173m2
0.30
366
3471
25
194
1.30
0.57
3.6
3.3
1.92
1.67
mmol/l
0.13
18
151
11
73
1.52
0.56
2.5
1.8
—
—
—
0
0
419
4084
1.13
0.52
5.6
5.1
38.67
38.71
mmol/mol
0.04
387
3808
16
118
1.37
0.50
1.6
1.3
—
—
—
0
0
13
177
0.73
0.48
1.3
1.7
261.69
312.34
mu/l
0.65
13
157
7
49
1.43
0.46
1.6
1.6
—
—
—
0
0
391
3808
1.11
0.44
4.8
4.5
14.50
14.55
pmol/l
0.19
361
3517
26
211
1.24
0.44
1.7
1.9
1970.40
3348.95
u/l
—
8
85
13
95
1.38
0.44
1.9
1.7
5.80
4.75
mmol/24h
0.64
13
81
5
31
1.62
0.43
1.4
1.4
2.76
1.90
mmol/l
—
5
31
8
56
1.44
0.42
1.5
1.5
—
—
—
0
0
8
57
1.41
0.42
1.5
1.6
—
—
—
0
0
10
70
1.44
0.42
1.2
1.1
1.40
1.95
u/ml
—
5
21
5
33
1.52
0.41
3.0
1.3
1.27
1.39
nmol/l
—
5
28
5
33
1.52
0.41
1.0
1.1
274.20
296.75
mg/l
—
5
28
19
238
0.79
0.41
1.2
1.5
—
—
—
0
0
314
3036
1.09
0.40
3.6
2.9
56.15
43.36
u/l
0.66
297
2855
436
4279
1.12
0.39
4.1
3.7
1.31
1.24
mmol/l
1.29
395
3954
5
35
1.43
0.39
3.2
3.9
—
—
—
0
0
5
35
1.43
0.39
1.4
1.8
—
—
—
0
0
12
89
1.36
0.38
2.2
1.6
—
—
—
0
0
442
4344
1.12
0.37
5.5
5.3
1.76
2.09
mu/l
0.62
410
4038
323
3131
1.08
0.37
3.2
3.3
—
—
—
0
0
10
72
1.40
0.37
1.3
1.2
—
—
—
0
0
14
108
1.30
0.35
1.7
1.5
—
—
—
0
0
6
45
1.34
0.34
2.0
2.2
—
—
—
0
0
130
1220
1.09
0.33
1.8
1.6
1.35
1.36
mmol/l
0.05
108
1043
77
705
1.11
0.33
3.7
3.5
183.11
258.03
ng/l
0.20
53
487
14
110
1.28
0.32
1.4
1.4
—
—
—
0
0
12
153
0.78
0.31
1.3
1.5
—
—
—
0
0
43
382
1.14
0.30
4.5
2.2
34.97
31.92
u/l
0.33
36
316
24
204
1.19
0.29
1.6
1.9
2.44
5.34
mg/l
0.51
16
149
10
76
1.32
0.28
1.6
2.8
8.06
7.99
kpa
—
10
76
17
140
1.22
0.28
4.2
1.9
—
—
—
0
0
451
4453
1.10
0.27
4.6
4.1
1.56
1.59
mmol/l
1.02
414
4143
27
234
1.16
0.27
2.0
1.5
—
—
—
0
0
8
66
1.22
0.27
1.5
1.6
—
—
—
0
0
42
466
0.89
0.26
2.0
1.6
—
—
—
0
0
12
148
0.81
0.25
1.3
1.4
—
—
—
0
0
12
148
0.81
0.25
1.2
1.4
—
—
—
0
0
12
148
0.81
0.25
1.2
1.4
—
—
—
0
0
12
148
0.81
0.25
1.3
1.4
—
—
—
0
0
12
96
1.26
0.24
1.1
1.1
0.34
1.96
u/ml
—
5
46
19
161
1.19
0.24
2.5
1.9
—
—
—
0
0
6
84
0.71
0.24
1.3
1.8
—
—
—
0
0
5
39
1.28
0.23
1.6
1.2
—
—
—
0
0
5
39
1.28
0.23
1.6
1.2
—
—
—
0
0
5
40
1.25
0.22
1.2
1.1
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
115.00
—
0
10
8
103
0.77
0.21
1.1
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
5.87
—
0
9
153
1474
1.05
0.19
4.8
2.9
31.90
28.34
u/l
0.70
147
1410
10
121
0.82
0.18
1.4
1.3
1387.40
434.05
mg/l
—
10
111
8
70
1.15
0.16
1.3
1.3
—
—
—
0
0
8
71
1.13
0.16
1.6
1.5
—
—
—
0
0
10
83
1.21
0.15
1.0
1.0
3.52
2.15
u/ml
—
5
43
8
96
0.83
0.14
2.3
1.5
—
—
—
0
0
8
98
0.81
0.14
3.6
3.5
57.75
58.31
%
—
8
98
44
417
1.06
0.10
4.1
3.9
2.72
10.44
ug/l
3.10
35
334
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.10
1.2
1.6
—
—
—
0
0
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.10
1.0
1.1
—
—
—
0
0
10
87
1.15
0.09
1.6
3.1
24.97
24.98
mmol/l
—
10
87
40
421
0.95
0.09
1.2
1.2
98.01
163.31
iu/ml
0.87
15
191
18
165
1.09
0.09
1.8
1.8
—
—
—
0
0
15
162
0.92
0.06
1.2
1.5
—
—
—
0
0
16
152
1.05
0.02
4.4
3.2
43.58
44.90
%
0.07
16
152
36
369
0.97
0.02
1.4
1.3
36.78
31.36
iu/l
0.36
31
321
16
153
1.05
0.01
1.3
1.5
—
—
—
0
0
35
344
1.02
0.00
4.3
3.6
1.24
1.24
mmol/l
0.13
30
301
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
6
65
0.92
-0.00
3.3
7.0
279.00
393.38
umol/l
—
6
58
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
69
1.01
-0.00
1.6
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
4.90
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
37.40
—
0
5
0
7
0.00
-0.00
0.0
2.6
—
1.18
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_VAGINAL_HSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VAGINAL_HSIL | 1.265 [1.08, 1.48] | 0.003 |
| Birth year | 0.998 [0.99, 1.01] | 0.566 |
During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 2226 females with N14_VAGINAL_HSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VAGINAL_HSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | No data |
| 5 | 0.774% | No data |
| 10 | 1.998% | No data |
| 15 | 3.721% | No data |
| 20 | 6.738% | No data |
Relationships between endpoints
↥Index endpoint: N14_VAGINAL_HSIL – HSIL lesion of the vagina
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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