≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

All dysplastic lesions of the vagina

Endpoint Browser PheWeb

N14_VAGINAL_DYSPLASIA_ALL

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

941

4. Check minimum number of events

None

941

5. Include endpoints

None

941

6. Filter based on genotype QC (FinnGen only)

941

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4910 4910 -
Only index persons 4706 4706 -
Unadjusted period prevalence (%)
Whole population 0.14 0.14 -
Only index persons 0.17 0.17 -
Median age at first event (years)
Whole population - 50.03 -
Only index persons - 49.20 -

-FinnGen-

Key figures

All Female Male
Number of individuals 941 941 -
Unadjusted period prevalence (%) 0.32 0.32 -
Median age at first event (years) 50.56 50.56 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
828
Matched controls
8280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N89.0
ICD-10 Finland
Mild vaginal dysplasia
+∞
323.0
449
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
25.2
323.0
579
698
ULA02
NOMESCO Finland
Kolposcopy
43.5
323.0
662
695
LEB00
NOMESCO Finland
Biopsy of vagina
97.8
323.0
415
84
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
410.6
289.3
275
10
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
+∞
278.3
251
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
12.0
213.1
490
893
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
15.7
212.2
391
447
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
+∞
198.1
182
*
N87.0
ICD-10 Finland
Mild cervical dysplasia
19.5
130.7
206
138
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
12.8
125.9
241
257
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
1212.2
111.2
106
*
LDA10
NOMESCO Finland
Curettage of cervix uteri
11.3
108.3
220
257
A63.0
ICD-10 Finland
Anogenital (venereal) warts
13.5
105.4
194
184
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
16.9
100.4
166
121
N87.1
ICD-10 Finland
Moderate cervical dysplasia
11.6
61.6
119
118
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
11.8
55.0
105
101
N90.0
ICD-10 Finland
Mild vulvar dysplasia
72.9
53.9
61
9
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
18.8
47.7
74
43
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
12.0
41.2
77
70
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
151.0
41.2
43
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
40.0
430
2365
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
14.5
36.4
62
46
N89.3
ICD-10 Finland
Dysplasia of vagina, unspecified
361.9
35.2
35
*
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
99.5
35.0
38
*
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
18.4
30.4
47
27
ZXC10
NOMESCO Finland
Use of laser
8.6
25.5
56
69
LEB10
NOMESCO Finland
Excision of lesion of vagina
18.4
24.1
37
21
D06BB10
ATC
imiquimod; topical
4.6
22.0
79
185
G01AA10
ATC
clindamycin; vaginal
2.3
20.6
239
1255
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
11.3
20.3
38
35
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
102.4
18.6
20
*
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
16.7
16
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.9
16.1
517
3918
ZXC00
NOMESCO Finland
Use of diathermy
12.9
14.4
25
20
6230B
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE MODERATA]
+∞
13.6
13
*
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
20.4
12.5
18
9
X86
ICPC
Abnormal cervix smear
7.8
12.5
28
37
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
12.3
120
568
L04AX01
ATC
azathioprine; systemic
3.3
11.5
58
185
D06BB04
ATC
podophyllotoxin; topical
2.8
10.8
70
262
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.2
9.9
104
509
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.0
9.5
137
761
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
8.2
9.4
20
25
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
2.9
9.1
54
194
C539, 6666, 0
ICD-O-3
NA
5.7
9.1
25
45
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
9.0
294
2105
L04AA06
ATC
mycophenolic acid; systemic
6.2
9.0
23
38
P01BA02
ATC
hydroxychloroquine; oral
2.2
8.9
93
455
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
8.7
158
953
N81.6
ICD-10 Finland
Rectocele
2.2
8.5
85
405
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
9.6
8.3
16
17
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
7.6
8.2
18
24
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
9.0
8.1
16
18
8411
FHL
Local change laser, coagulation, biopsy or removal
18.6
7.6
11
6
C52.91
ICD-10 Finland
Squamous cell carcinoma of the vagina
80.8
7.4
8
*
6230C
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE GRAVIS]
+∞
7.3
7
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
7.2
253
1825
R87.0
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of enzymes
20.2
7.1
10
5
H02AB06
ATC
prednisolone; systemic
1.5
7.0
364
2861
N89.9
ICD-10 Finland
Noninflammatory disorder of vagina, unspecified
11.0
6.8
12
11
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
40.4
6.8
8
*
LEC00
NOMESCO Finland
Partial excision of vagina
40.4
6.8
8
*
LFC00
NOMESCO Finland
Partial excision of vulva
16.9
6.8
10
6
G01AF01
ATC
metronidazole; vaginal
1.8
6.7
126
764
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
22.7
6.7
9
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.8
6.7
116
687
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
70.4
6.4
7
*
8326
FHL
Batch conization
7.5
6.4
14
19
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.8
6.3
25
68
N89.5
ICD-10 Finland
Stricture and atresia of vagina
18.2
6.3
9
5
A07EC01
ATC
sulfasalazine; oral, rectal
2.0
6.2
74
385
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
12.6
6.1
10
8

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
179
187
11.59
158.49
3.6
1.8
—
—
—
0
0
588
3642
2.64
44.52
3.8
2.0
—
—
—
0
0
151
711
2.34
18.36
1.4
1.4
—
—
—
0
0
149
770
2.11
14.24
4.0
3.6
—
—
—
0
0
712
6069
1.71
11.09
5.5
4.1
12.3
11.4
mm/h
1.10
660
5644
16
22
7.38
11.01
3.7
2.7
—
—
—
0
0
113
589
2.04
10.44
3.1
3.0
10.9
10.2
g/l
0.81
105
550
265
1850
1.60
9.04
2.4
2.1
—
—
—
0
0
195
1271
1.67
8.72
1.7
1.3
605.0
564.5
titre
0.13
56
295
515
4190
1.51
8.59
9.1
5.8
0.2
0.2
e9/l
0.04
472
3732
507
4148
1.48
7.99
8.8
5.5
1.9
2.0
e9/l
0.26
470
3703
87
457
2.00
7.86
1.8
1.8
1.3
1.4
g/l
0.10
78
423
493
4019
1.48
7.86
8.9
5.5
0.5
0.5
e9/l
0.16
449
3527
34
118
2.95
7.65
1.8
1.2
—
—
—
0
0
58
265
2.27
7.50
1.6
1.2
10.2
11.1
u/ml
0.05
15
54
57
259
2.28
7.47
1.6
1.2
9.3
1.9
u/ml
0.60
13
29
326
2477
1.48
7.27
2.5
2.2
—
—
—
0
0
422
3372
1.46
7.26
6.7
5.1
1.2
1.2
mmol/l
1.02
367
3060
491
4040
1.45
7.22
8.9
5.5
0.0
0.0
e9/l
0.34
447
3540
401
3181
1.45
7.13
5.8
4.1
36.2
36.2
g/l
0.04
368
2970
460
3769
1.43
6.75
8.6
5.6
2.7
2.7
%
0.00
432
3514
461
3785
1.43
6.65
9.0
5.9
8.2
8.1
%
0.14
432
3554
18
45
4.06
6.64
1.7
2.0
795.4
819.0
e6/l
—
8
18
458
3757
1.43
6.63
8.0
5.8
1.2
1.2
mmol/l
0.15
388
3167
445
3643
1.42
6.46
8.6
5.7
0.7
0.7
%
0.01
415
3395
472
3907
1.42
6.42
8.7
5.7
29.7
29.3
%
0.37
440
3652
464
3838
1.41
6.29
3.9
3.8
—
—
—
0
0
466
3863
1.41
6.21
8.6
5.4
56.0
56.6
%
0.57
437
3623
51
240
2.19
6.18
2.1
2.1
1.4
1.5
g/l
0.41
43
210
235
1720
1.49
6.15
1.5
1.5
2.2
2.2
g/l
0.02
143
1050
693
6173
1.47
6.11
10.0
6.8
74.8
75.4
u/l
0.19
661
5798
331
2591
1.43
6.08
8.4
5.5
—
—
—
0
0
241
1800
1.46
5.63
4.9
3.5
—
—
—
0
0
229
1697
1.46
5.57
1.6
1.5
21.6
22.0
nmol/l
0.15
194
1464
127
836
1.60
5.34
8.3
4.4
1.1
1.0
mmol/l
0.13
118
759
631
5595
1.39
5.18
5.9
4.2
—
—
—
0
0
324
2588
1.38
5.10
3.2
3.2
24.6
41.8
ng/l
0.52
182
1537
103
653
1.65
5.04
3.1
2.0
0.2
0.2
g/l
0.23
98
620
543
4714
1.36
5.00
12.0
8.6
3.8
3.9
e9/l
0.95
491
4164
31
132
2.39
4.78
1.3
1.5
—
—
—
0
0
27
108
2.54
4.74
1.9
2.9
1.3
1.5
%
0.12
21
84
172
1241
1.47
4.74
1.7
1.7
1098.3
1231.1
nmol/l
1.22
133
938
370
3046
1.35
4.74
2.0
1.9
101.0
99.3
pmol/l
0.23
183
1503
124
835
1.56
4.73
1.7
1.6
—
—
—
0
0
159
1132
1.49
4.68
2.6
2.1
143.0
101.6
ug/g
0.54
116
879
80
486
1.71
4.61
11.1
6.6
9.0
8.0
mmol/l
0.78
75
462
19
64
3.01
4.57
2.4
3.2
—
—
—
0
0
189
1398
1.44
4.57
1.6
1.6
—
—
—
0
0
263
2062
1.38
4.55
1.3
1.3
1.2
1.6
u/ml
0.25
67
554
10
21
4.80
4.54
2.0
1.2
—
—
—
0
0
133
927
1.51
4.34
1.6
1.4
—
—
—
0
0
107
713
1.56
4.28
2.9
3.1
28.8
51.9
u/ml
1.43
102
687
18
62
2.94
4.19
1.6
2.2
1.6
1.2
e9/l
—
9
40
242
1908
1.36
3.98
2.6
2.1
2.7
3.0
mg/l
1.33
204
1635
89
580
1.59
3.93
5.1
3.3
—
—
—
0
0
41
215
1.95
3.83
4.0
2.8
—
—
—
0
0
26
114
2.32
3.81
1.4
1.6
0.5
0.8
g/l
0.60
21
93
118
828
1.49
3.73
4.3
2.3
6.7
5.9
umol/l
0.23
106
706
211
1644
1.37
3.72
1.9
1.8
—
—
—
0
0
296
2431
1.32
3.66
3.4
2.3
55.5
55.7
u/l
0.04
279
2241
12
35
3.46
3.62
4.2
2.8
—
—
—
0
0
92
618
1.54
3.57
1.2
1.3
135.1
208.9
u/ml
0.73
87
577
465
4065
1.28
3.55
4.5
3.5
0.0
0.0
estimate
0.80
77
750
489
4303
1.28
3.54
4.8
4.1
6.5
6.5
mmol/l
0.00
455
3968
143
1052
1.42
3.54
3.7
2.5
4.6
4.5
e6/l
0.04
79
525
89
595
1.55
3.53
1.5
1.3
—
—
—
0
0
305
2526
1.31
3.52
3.4
2.8
—
—
—
0
0
33
167
2.01
3.42
3.7
3.9
35.3
26.0
mg/l
0.48
33
132
33
167
2.01
3.42
3.7
3.9
35.7
35.4
mg/l
0.02
33
134
74
478
1.59
3.41
3.5
2.5
73.2
75.2
e9/l
0.20
58
357
460
4029
1.28
3.41
5.9
4.8
0.0
0.0
estimate
0.50
75
760
17
64
2.69
3.41
3.9
2.6
—
—
—
0
0
270
2211
1.31
3.37
2.4
2.1
107.7
171.4
u/l
1.42
256
2087
26
122
2.16
3.28
1.7
1.3
116.3
123.2
u/ml
—
8
28
104
731
1.48
3.27
1.3
1.2
—
—
—
0
0
455
3994
1.27
3.26
4.5
3.5
0.0
0.0
estimate
0.00
70
758
72
468
1.58
3.24
9.0
7.7
—
—
—
0
0
8
15
5.37
3.19
1.6
2.0
—
—
—
0
0
28
137
2.08
3.19
1.6
1.4
—
—
—
0
0
150
1134
1.38
3.17
4.2
2.9
0.8
0.8
mmol/l
0.74
139
1060
239
1942
1.31
3.13
4.0
2.8
0.3
0.4
e6/l
0.32
180
1430
262
2160
1.30
3.07
3.4
3.0
6.5
6.8
mmol/l
0.71
217
1840
5
5
10.04
2.98
5.4
2.0
3.9
4.5
mg/l
—
5
5
237
1937
1.30
2.96
3.9
2.7
—
—
—
0
0
13
46
2.85
2.92
1.2
1.2
104.0
88.6
titre
—
5
7
134
1008
1.38
2.92
3.3
2.1
2.3
2.4
g/l
1.32
123
932
16
64
2.53
2.88
1.1
1.2
—
—
—
0
0
58
370
1.60
2.85
1.8
1.8
—
—
—
0
0
455
4043
1.24
2.78
7.8
5.4
9.2
10.0
umol/l
1.50
439
3810
320
2736
1.26
2.75
3.1
3.3
2.4
2.4
mmol/l
0.02
268
2431
122
915
1.38
2.71
3.5
2.2
24.0
22.8
%
0.51
108
774
60
391
1.57
2.71
1.5
1.3
2.6
1.1
u/ml
—
5
34
53
339
1.60
2.60
1.3
1.2
—
—
—
0
0
848
8150
1.41
2.56
16.4
11.9
17.9
19.6
mg/l
0.92
674
6280
254
2130
1.26
2.55
4.2
2.9
27.8
50.1
e6/l
1.07
195
1599
248
2076
1.26
2.52
8.8
6.3
—
—
—
0
0
185
1494
1.30
2.51
3.1
2.4
8.1
8.2
e6/l
0.01
159
1311
16
69
2.34
2.49
2.1
1.4
1.0
1.0
g/l
0.07
16
69
91
659
1.42
2.49
3.8
2.7
2.0
1.9
%
0.71
78
585
249
2089
1.26
2.48
3.6
3.3
—
—
—
0
0
41
249
1.68
2.47
7.4
7.9
—
—
—
0
0
251
2110
1.26
2.46
5.1
3.9
0.0
0.0
estimate
1.08
73
763
225
1867
1.27
2.46
3.5
2.3
313.9
4974.4
umol/l
6.30
199
1636
14
57
2.48
2.45
2.2
1.3
—
—
—
0
0
119
907
1.36
2.41
1.5
1.2
—
—
—
0
0
82
588
1.43
2.37
2.8
2.8
4.3
4.1
e9/l
0.40
68
480
87
631
1.42
2.37
3.3
3.3
4.5
4.5
pmol/l
0.18
78
556
206
1703
1.27
2.31
5.5
3.9
1.0
1.0
kg/l
0.59
17
248
83
600
1.42
2.31
5.0
4.0
0.0
1.4
%
0.85
28
125
13
53
2.47
2.28
1.2
1.1
—
—
—
0
0
6
13
4.64
2.27
4.2
3.2
—
—
—
0
0
852
8220
1.39
2.27
15.9
12.7
139.6
139.7
mmol/l
0.32
825
7999
818
7845
1.33
2.25
4.5
4.2
5.7
5.8
mmol/l
1.93
740
7247
82
596
1.41
2.22
4.9
3.2
117.8
75.4
ng/l
2.06
72
529
17
80
2.15
2.19
1.5
1.2
—
—
—
0
0
25
136
1.86
2.19
1.4
1.5
1.9
3.4
ug/l
0.82
18
117
853
8238
1.38
2.19
16.2
12.8
3.9
3.9
mmol/l
0.01
823
7998
303
2630
1.22
2.19
4.9
3.4
65.2
68.5
e6/l
0.05
209
1745
201
1668
1.26
2.18
4.9
3.8
—
—
—
0
0
888
8638
1.50
2.18
13.3
9.6
23.7
23.6
u/l
0.06
859
8371
90
668
1.38
2.16
4.8
3.9
0.6
1.0
%
1.14
35
169
64
447
1.46
2.15
2.1
2.3
—
—
—
0
0
11
43
2.58
2.10
1.1
1.1
—
—
—
0
0
234
1986
1.24
2.08
3.5
3.2
64.2
257.4
mg/l
1.44
123
1169
16
76
2.12
2.03
1.4
1.4
—
—
—
0
0
139
1112
1.29
2.03
3.5
2.2
13.1
13.5
umol/l
0.30
124
1023
659
6963
0.82
2.02
18.4
14.4
13.6
13.6
%
0.08
646
6813
8
26
3.09
2.01
5.8
2.2
—
—
—
0
0
24
133
1.83
2.01
4.4
4.3
—
—
—
0
0
101
774
1.34
2.00
2.3
2.0
378.2
375.3
nmol/l
0.05
90
718
192
1603
1.25
1.98
1.5
1.6
27059268.0
30752653.1
pmol/l
0.04
170
1356
136
1089
1.29
1.97
1.3
1.2
—
—
—
0
0
51
347
1.50
1.96
1.4
1.3
174.9
230.2
miu/ml
0.53
27
174
18
91
2.00
1.96
2.9
2.5
—
—
—
0
0
33
203
1.65
1.94
1.5
1.4
26.2
27.5
u/l
0.07
24
167
6
16
3.77
1.93
1.3
1.5
—
—
—
0
0
922
9065
1.85
1.93
23.7
17.9
268.0
265.9
e9/l
0.46
902
8877
85
638
1.37
1.93
5.0
3.9
0.0
0.1
%
1.68
32
156
22
121
1.84
1.89
1.3
1.4
—
—
—
0
0
922
9068
1.83
1.88
23.6
17.9
91.1
90.8
fl
1.69
911
8960
18
93
1.95
1.86
1.4
1.3
—
—
—
0
0
922
9070
1.82
1.85
23.7
17.9
4.4
4.4
e12/l
2.08
901
8855
922
9070
1.82
1.85
23.6
17.8
30.3
30.1
pg
2.54
911
8961
922
9072
1.81
1.82
23.7
18.0
6.7
6.6
e9/l
0.09
901
8857
242
2089
1.21
1.81
4.1
3.8
13.0
7.8
mg/mmol
0.59
127
1225
922
9073
1.80
1.80
23.8
18.0
132.0
132.7
g/l
1.08
910
8968
81
611
1.36
1.79
4.7
3.7
0.4
0.7
%
1.14
25
120
96
745
1.32
1.77
25.5
19.5
1.2
1.2
inr
0.01
15
114
10
41
2.45
1.76
1.0
1.0
—
—
—
0
0
165
1375
1.24
1.73
3.5
2.5
485.6
514.4
mosm/kgh2o
1.00
141
1165
298
2637
1.19
1.70
7.0
7.3
1.2
1.1
inr
0.27
68
820
164
1369
1.24
1.70
2.6
2.6
2.4
2.4
mmol/l
0.06
140
1212
6
145
0.41
1.65
2.7
2.6
1.2
1.4
mmol/l
—
6
140
11
49
2.26
1.64
2.3
2.0
—
—
—
0
0
273
3074
0.84
1.61
2.3
2.6
—
—
—
0
0
7
26
2.70
1.58
1.1
1.2
455.3
366.6
pmol/l
—
7
18
193
1652
1.21
1.57
1.4
1.3
10.2
13.1
u/ml
0.26
75
673
8
33
2.44
1.54
5.8
2.2
—
—
—
0
0
116
942
1.26
1.53
1.5
1.4
—
—
—
0
0
7
27
2.60
1.51
1.6
2.7
—
—
—
0
0
7
27
2.60
1.51
1.0
1.2
—
—
—
0
0
39
267
1.48
1.51
4.6
3.4
—
—
—
0
0
6
21
2.87
1.50
1.7
1.0
—
—
—
0
0
12
58
2.08
1.49
1.0
1.1
300.8
297.6
mg/l
0.08
12
50
877
8574
1.34
1.45
14.2
11.2
—
—
—
0
0
5
16
3.14
1.44
1.4
2.8
16.8
19.3
umol/l
—
5
16
5
16
3.14
1.44
1.2
1.1
—
—
—
0
0
6
22
2.74
1.43
1.5
7.0
58.7
79.1
mg/l
—
6
14
64
485
1.34
1.42
1.2
1.2
—
—
—
0
0
53
708
0.73
1.40
4.0
3.7
—
—
—
0
0
429
3959
1.15
1.39
3.3
2.8
92.8
81.4
ug/l
0.86
401
3696
829
8057
1.24
1.37
4.4
4.1
4.9
4.9
mmol/l
0.30
769
7570
36
248
1.47
1.37
1.6
1.2
—
—
—
0
0
22
135
1.64
1.36
1.1
1.2
—
—
—
0
0
840
8183
1.25
1.31
4.8
4.5
2.9
2.9
mmol/l
0.21
769
7631
6
24
2.51
1.30
4.2
1.9
—
—
—
0
0
9
43
2.10
1.30
2.9
1.8
1.3
1.4
nmol/l
—
9
38
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
71
556
1.30
1.28
6.1
2.9
1.3
2.2
mmol/l
1.16
63
447
139
1178
1.21
1.27
1.2
1.2
—
—
—
0
0
252
2250
1.16
1.26
5.9
3.5
7.4
7.4
ph
0.05
39
440
21
131
1.62
1.24
1.0
1.0
0.9
2.2
u/ml
—
5
41
61
470
1.32
1.24
2.5
2.2
4.1
6.1
ug/l
0.96
48
421
38
272
1.41
1.21
4.0
2.2
0.6
0.7
%
0.33
38
261
24
358
0.66
1.20
5.0
3.2
—
—
—
0
0
26
174
1.51
1.16
1.9
2.3
—
—
—
0
0
383
3548
1.13
1.12
10.8
8.6
0.0
0.0
e9/l
0.20
317
2920
66
523
1.28
1.11
2.5
2.8
67.4
67.5
g/l
0.03
57
486
7
31
2.27
1.10
1.0
1.6
124.7
147.9
nmol/l
—
7
31
17
104
1.65
1.10
1.1
1.3
—
—
nmol/l
—
0
0
19
120
1.60
1.09
1.0
1.0
—
—
—
0
0
17
106
1.61
1.03
1.2
1.2
—
—
—
0
0
33
239
1.39
1.01
1.4
1.4
306.0
302.2
ug/g
0.03
21
128
191
1700
1.15
1.00
1.4
1.3
21.4
29.8
iu/ml
1.07
59
568
211
1897
1.14
0.96
1.7
1.7
0.9
0.9
mg/l
0.04
154
1436
33
242
1.38
0.96
5.6
4.3
—
—
—
0
0
40
303
1.33
0.95
7.6
9.3
23.8
24.4
mmol/l
0.79
34
285
6
118
0.51
0.94
3.5
6.4
277.5
377.2
umol/l
—
6
103
15
93
1.62
0.94
2.1
2.2
—
—
—
0
0
751
7296
1.15
0.92
5.3
5.1
38.3
38.9
mmol/mol
1.28
687
6831
35
261
1.35
0.92
1.3
1.2
—
—
—
0
0
13
78
1.68
0.92
1.4
1.4
—
—
—
0
0
13
78
1.68
0.92
1.4
1.4
—
—
—
0
0
13
78
1.68
0.92
1.4
1.4
—
—
—
0
0
13
78
1.68
0.92
1.4
1.4
—
—
—
0
0
10
170
0.58
0.90
4.9
4.3
—
—
—
0
0
117
1015
1.17
0.86
2.1
1.9
—
—
—
0
0
11
64
1.73
0.86
1.1
1.3
—
—
—
0
0
67
553
1.23
0.84
1.5
1.4
—
—
—
0
0
8
45
1.78
0.84
3.0
1.8
9.4
10.1
%
—
8
45
10
57
1.76
0.84
6.3
1.6
40.3
7.7
ug/l
—
10
46
47
373
1.27
0.83
4.1
3.3
5.1
5.2
kpa
0.14
42
356
31
232
1.35
0.82
3.1
2.9
18.2
734.6
u/ml
0.66
24
202
6
32
1.88
0.82
1.7
1.8
—
—
—
0
0
716
6955
1.12
0.80
4.8
4.4
14.6
14.6
pmol/l
0.22
663
6473
0
25
0.00
0.79
0.0
3.2
—
—
—
0
0
818
8016
1.16
0.79
4.4
4.1
1.6
1.6
mmol/l
0.01
749
7494
19
131
1.46
0.78
1.3
1.2
—
—
—
0
0
47
376
1.26
0.78
4.0
2.7
125.7
127.6
g/l
0.30
47
365
41
323
1.28
0.77
1.3
1.5
159.9
200.7
pmol/l
0.19
41
316
6
34
1.77
0.76
2.5
3.3
4568.3
634.7
u/ml
—
6
34
15
99
1.52
0.76
2.9
3.3
0.8
0.8
nmol/l
—
10
80
9
53
1.70
0.75
1.2
1.2
25.3
30.0
nmol/l
—
9
38
30
227
1.33
0.75
1.3
1.1
—
—
—
0
0
12
75
1.61
0.75
1.0
1.1
—
—
—
0
0
16
108
1.49
0.74
1.1
1.3
—
—
—
0
0
38
299
1.28
0.73
2.3
1.5
—
—
—
0
0
5
25
2.01
0.72
1.4
1.1
—
—
—
0
0
14
92
1.53
0.72
2.2
1.4
—
—
—
0
0
9
56
1.61
0.72
4.4
7.2
—
—
—
0
0
213
1954
1.12
0.72
6.5
4.2
—
—
—
0
0
5
26
1.93
0.70
1.8
1.8
—
—
—
0
0
38
301
1.27
0.70
2.3
1.5
—
—
—
0
0
17
118
1.45
0.69
1.1
1.0
—
—
—
0
0
5
27
1.86
0.68
2.6
2.2
9.6
9.5
mg/l
—
5
22
14
94
1.50
0.67
2.1
1.7
60.7
59.4
%
0.08
14
94
10
155
0.64
0.66
1.1
1.1
—
—
—
0
0
20
145
1.39
0.66
1.1
1.2
2.6
5.0
u/ml
—
7
52
80
693
1.17
0.64
5.8
7.2
0.8
1.4
mmol/l
0.86
59
551
18
129
1.40
0.63
2.2
2.2
—
—
—
0
0
31
243
1.29
0.63
2.9
3.0
0.4
0.3
g/l
0.10
12
72
107
950
1.14
0.62
1.4
1.6
—
—
—
0
0
45
371
1.22
0.61
1.0
1.1
—
—
—
0
0
8
50
1.61
0.61
1.0
1.3
—
—
—
0
0
37
299
1.25
0.60
2.4
1.5
—
—
—
0
0
17
122
1.40
0.60
1.1
1.0
1.2
4.1
u/ml
—
6
40
6
35
1.72
0.57
2.8
2.2
3.7
3.3
ug/l
—
6
29
786
7718
1.11
0.57
4.0
3.7
1.3
1.2
mmol/l
0.58
708
7172
59
687
0.85
0.57
1.4
1.3
37.4
29.8
iu/l
0.76
49
588
5
88
0.57
0.56
1.4
1.9
88.1
90.1
%
—
5
88
30
239
1.26
0.56
2.4
1.5
—
—
—
0
0
19
251
0.75
0.55
1.3
1.4
—
—
—
0
0
6
37
1.63
0.55
7.2
1.9
9.3
9.1
mmol/l
—
6
30
34
276
1.24
0.54
2.5
1.5
—
—
—
0
0
71
619
1.16
0.54
1.3
1.2
—
—
—
0
0
12
82
1.47
0.54
1.4
1.6
—
—
—
0
0
19
250
0.76
0.54
1.3
1.4
—
—
—
0
0
6
38
1.58
0.54
2.3
2.1
23.7
232.3
ug/l
—
6
33
79
695
1.15
0.54
5.9
7.2
5.1
5.1
kpa
0.12
74
670
79
695
1.15
0.54
5.9
7.2
14.3
12.7
kpa
1.03
73
667
801
7880
1.11
0.53
5.6
5.2
1.7
2.0
mu/l
0.84
739
7367
16
118
1.36
0.50
1.1
1.3
—
0.5
—
0
5
10
68
1.48
0.47
1.1
1.0
—
—
—
0
0
772
7594
1.09
0.47
15.4
12.8
39.4
39.3
%
0.27
577
5770
35
292
1.21
0.45
2.2
1.5
—
—
—
0
0
12
164
0.73
0.45
3.4
3.5
4.5
4.2
e9/l
0.21
12
164
19
149
1.28
0.42
2.7
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.9
—
—
—
0
0
5
34
1.47
0.40
1.4
2.0
—
—
—
0
0
10
71
1.41
0.39
1.5
1.5
—
—
—
0
0
47
537
0.87
0.39
2.7
2.7
—
—
—
0
0
22
178
1.24
0.39
1.2
1.6
—
—
—
0
0
13
169
0.77
0.37
3.5
3.8
62.2
58.1
%
0.49
13
169
13
168
0.77
0.36
1.0
1.1
6.7
2.7
u/ml
—
5
75
15
190
0.79
0.36
1.1
1.1
—
—
—
0
0
25
208
1.21
0.35
3.3
2.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.4
—
—
—
0
0
27
319
0.84
0.34
1.3
1.3
—
—
—
0
0
50
445
1.13
0.33
2.0
2.1
1089.7
3204.4
u/l
0.93
16
182
108
1004
1.09
0.32
2.0
1.9
—
—
—
0
0
8
107
0.75
0.29
1.4
2.4
—
—
—
0
0
7
57
1.23
0.29
1.6
1.4
—
2518.4
—
0
8
34
298
1.15
0.28
4.7
2.9
25.0
25.7
mmol/l
0.90
34
288
12
151
0.79
0.28
1.3
1.9
137.8
131.7
g/l
—
6
110
34
299
1.14
0.27
2.6
1.9
23.5
20.6
s
1.64
29
259
22
258
0.85
0.27
1.3
1.5
—
—
—
0
0
54
593
0.91
0.27
1.5
1.4
—
—
—
0
0
36
405
0.88
0.26
2.9
4.8
—
—
—
0
0
77
714
1.09
0.26
3.9
3.8
3.3
9.3
ug/l
3.02
62
565
11
138
0.79
0.25
2.2
2.9
—
—
—
0
0
52
476
1.10
0.23
2.8
2.6
108.5
147.1
ng/l
1.09
46
439
10
125
0.80
0.23
1.2
1.1
—
—
—
0
0
5
39
1.28
0.23
1.4
1.1
83.6
510.8
u/l
—
5
34
125
1314
0.94
0.22
3.2
3.3
157.0
324.4
ng/l
0.87
84
883
5
41
1.22
0.22
2.2
3.2
—
—
—
0
0
50
459
1.09
0.21
1.1
1.1
—
202.8
—
0
9
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
4.4
—
0.2
—
0
10
73
683
1.07
0.21
1.9
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
16
136
1.18
0.20
2.5
1.8
—
—
—
0
0
18
155
1.16
0.20
1.1
1.1
—
—
—
0
0
18
155
1.16
0.20
1.1
1.1
—
—
—
0
0
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
6
52
1.15
0.19
1.2
1.2
—
—
—
0
0
7
59
1.19
0.18
1.9
1.3
—
62.3
—
0
8
7
61
1.15
0.17
2.4
1.9
—
—
—
0
0
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
39
360
1.09
0.16
1.1
1.1
—
—
—
0
0
11
92
1.20
0.16
1.4
1.6
—
—
—
0
0
222
2279
0.97
0.16
3.4
3.2
—
—
—
0
0
8
73
1.10
0.15
1.0
1.1
—
—
—
0
0
6
77
0.78
0.15
1.2
1.1
—
—
—
0
0
6
80
0.75
0.15
1.8
2.6
—
—
—
0
0
16
140
1.15
0.15
1.1
1.1
—
—
—
0
0
557
5507
1.03
0.14
3.7
3.3
—
—
—
0
0
10
116
0.86
0.12
1.5
1.5
—
—
—
0
0
39
368
1.06
0.10
1.4
1.6
—
—
—
0
0
15
135
1.11
0.09
1.3
1.1
—
—
—
0
0
5
46
1.09
0.09
2.2
3.0
—
—
—
0
0
20
185
1.08
0.08
1.1
1.1
0.5
2.0
u/ml
—
6
71
38
399
0.95
0.08
2.9
2.4
—
—
—
0
0
6
70
0.86
0.07
4.3
2.5
—
—
—
0
0
8
78
1.03
0.07
1.5
1.6
33.4
31.5
pg
—
8
78
7
82
0.85
0.07
2.4
1.3
1.2
1.9
nmol/l
—
7
67
10
89
1.12
0.07
1.1
1.7
—
—
—
0
0
10
89
1.12
0.07
1.0
1.1
—
—
—
0
0
100
980
1.02
0.05
1.5
1.4
—
—
—
0
0
30
314
0.95
0.05
7.3
10.0
—
—
—
0
0
92
901
1.02
0.05
1.3
1.3
—
—
—
0
0
25
263
0.95
0.05
1.4
1.3
—
—
—
0
0
228
2304
0.99
0.05
1.4
1.5
—
—
—
0
0
13
120
1.08
0.05
1.5
1.3
—
—
—
0
0
15
140
1.07
0.04
3.5
1.7
—
—
—
0
0
215
2167
0.99
0.03
1.7
1.6
1.3
1.3
mmol/l
0.17
188
1862
18
189
0.95
0.03
1.3
1.5
71.2
11.4
e6/l
0.67
12
149
18
189
0.95
0.03
1.3
1.6
281.6
410.9
e6/l
0.16
12
156
27
262
1.03
0.02
2.1
1.9
2.9
5.1
iu/l
1.51
11
101
11
117
0.94
0.01
1.1
1.1
—
—
—
0
0
19
183
1.04
0.01
2.1
2.1
—
—
—
0
0
101
1002
1.01
0.01
2.6
1.9
28.9
29.4
s
0.52
101
971
14
136
1.03
0.00
1.7
1.7
—
—
—
0
0
77
772
1.00
0.00
1.5
1.4
—
—
—
0
0
78
775
1.01
0.00
1.2
1.2
94.5
146.1
iu/ml
1.12
28
319
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
4.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
0.00
2.3
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
4.1
—
0
9
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.1
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint N14_VAGINAL_DYSPLASIA_ALL and mortality.

Females

Parameter HR [95% CI] p-value
N14_VAGINAL_DYSPLASIA_ALL 1.242 [1.1, 1.41] < 0.001
Birth year 0.995 [0.99, 1.0] 0.289

During the follow-up period (1.1.1998 — 31.12.2019), 449 out of 4114 females with N14_VAGINAL_DYSPLASIA_ALL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_VAGINAL_DYSPLASIA_ALL.

N-year risk Females Males
1 0.054% No data
5 0.636% No data
10 1.703% No data
15 3.337% No data
20 6.267% No data

Relationships between endpoints

↥

Index endpoint: N14_VAGINAL_DYSPLASIA_ALL – All dysplastic lesions of the vagina

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data