No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditionsNone |
293218 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1025 |
4. Check minimum number of eventsNone |
1025 |
5. Include endpointsNone |
1025 |
6. Filter based on genotype QC (FinnGen only) |
996 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
All dysplastic lesions of the vagina
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4910 | 4910 | - |
| Only index persons | 4706 | 4706 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.14 | - |
| Only index persons | 0.17 | 0.17 | - |
| Median age at first event (years) | |||
| Whole population | - | 50.03 | - |
| Only index persons | - | 49.20 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 996 | 996 | - |
| Unadjusted period prevalence (%) | 0.35 | 0.35 | - |
| Median age at first event (years) | 51.72 | 51.72 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1025
- Matched controls
- 10250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
+∞
321.3
291
*
N89.0
ICD-10 Finland
Mild vaginal dysplasia
+∞
307.7
573
*
ULA02
NOMESCO Finland
Kolposcopy
40.6
307.7
814
889
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
384.0
307.7
336
13
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
12.4
307.7
616
1113
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
15.0
307.7
477
562
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
24.2
307.7
714
888
LEB00
NOMESCO Finland
Biopsy of vagina
126.1
307.7
523
84
N87.0
ICD-10 Finland
Mild cervical dysplasia
19.6
301.0
255
170
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
+∞
262.0
240
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
12.6
258.3
292
313
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
16.7
236.6
214
159
A63.0
ICD-10 Finland
Anogenital (venereal) warts
15.1
236.2
229
192
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.9
201.0
269
356
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
17.9
172.7
146
94
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
+∞
153.0
143
*
N90.0
ICD-10 Finland
Mild vulvar dysplasia
68.5
149.6
82
13
N87.1
ICD-10 Finland
Moderate cervical dysplasia
11.2
127.5
143
146
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
12.9
106.5
107
92
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
9.2
101.3
131
161
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
53.8
97.7
56
11
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
16.0
95.7
84
57
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
26.5
86.2
60
24
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
44.7
85.5
51
12
LEB10
NOMESCO Finland
Excision of lesion of vagina
20.8
55.0
42
21
ZXC10
NOMESCO Finland
Use of laser
8.1
49.8
69
91
D06BB10
ATC
imiquimod; topical
5.0
48.3
110
239
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.4
42.8
536
3173
N89.3
ICD-10 Finland
Dysplasia of vagina, unspecified
+∞
40.9
39
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
8.2
32.6
44
56
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.1
25.0
702
5258
L04AX01
ATC
azathioprine; systemic
3.9
24.9
75
201
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
44.0
24.7
30
7
G01AA10
ATC
clindamycin; vaginal
2.1
23.5
282
1556
X86
ICPC
Abnormal cervix smear
7.6
22.6
32
43
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
34.6
21.2
27
8
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
18.8
18
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.2
18.8
194
1001
D06BB04
ATC
podophyllotoxin; topical
2.8
16.9
86
320
6230B
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE MODERATA]
+∞
16.7
16
*
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
22.4
15.6
22
10
L04AA06
ATC
mycophenolic acid; systemic
5.3
15.4
31
60
127
Kela drug reimbursment
Transplant complication
6.8
15.4
24
36
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
14.0
141
715
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.4
13.4
93
404
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
13.1
379
2672
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
12.9
207
1234
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
11.9
122
622
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
12.0
11.4
20
17
L04AA01
ATC
[U] ciclosporin
5.0
11.2
24
49
ZXC00
NOMESCO Finland
Use of diathermy
8.2
11.1
24
30
ULC02
NOMESCO Finland
Hysteroscopy
2.3
11.0
88
407
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.4
10.8
72
307
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
5.3
10.6
21
40
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
2.8
10.5
53
197
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
9.2
10.0
20
22
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
9.8
329
2367
J02AC01
ATC
fluconazole; systemic
1.5
9.6
539
4332
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.3
9.4
34
104
R87.0
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal level of enzymes
21.9
9.4
13
6
P01BA02
ATC
hydroxychloroquine; oral
2.0
9.2
110
593
LEC00
NOMESCO Finland
Partial excision of vagina
37.0
9.0
11
*
TK800
NOMESCO Finland
Hemodialysis
4.7
8.8
20
43
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
2.3
8.7
64
285
C52.91
ICD-10 Finland
Squamous cell carcinoma of the vagina
50.4
8.7
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
8.7
120
679
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.6
8.4
264
1862
6230C
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE GRAVIS]
+∞
8.3
8
*
J01EA01
ATC
trimethoprim; systemic
1.5
8.3
319
2352
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
8.2
392
3016
L04AD02
ATC
tacrolimus; systemic
7.6
8.2
18
24
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.1
394
3042
N81.6
ICD-10 Finland
Rectocele
1.9
8.1
100
545
8326
FHL
Batch conization
10.1
8.0
15
15
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.7
8.0
43
165
R50.9
ICD-10 Finland
Fever, unspecified
1.7
7.9
139
846
L01BA01
ATC
methotrexate; systemic
2.5
7.8
47
191
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.1
7.7
32
107
Z94.4
ICD-10 Finland
Liver transplant status
25.2
7.6
10
*
LCD10
NOMESCO Finland
Vaginal hysterectomy
2.3
7.5
58
264
L04AD01
ATC
ciclosporin; systemic
3.6
7.4
24
68
G01AF01
ATC
metronidazole; vaginal
1.7
7.3
146
918
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
7.3
445
3567
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
7.2
278
2038
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.2
297
2211
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
7.0
18
43
N30.0
ICD-10 Finland
Acute cystitis
1.6
7.0
191
1299
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.0
342
2629
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.7
6.9
21
57
C539, 6666, 0
ICD-O-3
3.6
6.9
22
62
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.8
116
698
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
40.3
6.8
8
*
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
16.8
6.8
10
6
UJF32
NOMESCO Finland
Coloscopy
1.5
6.7
232
1660
LEB20
NOMESCO Finland
Marsupialisation of vaginal cyst
22.7
6.7
9
*
M05BA04
ATC
alendronic acid; oral
1.9
6.6
84
462
N89.9
ICD-10 Finland
Noninflammatory disorder of vagina, unspecified
7.9
6.6
14
18
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
12.3
6.6
11
9
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
12.3
6.6
11
9
K50.1
ICD-10 Finland
Crohn disease of large intestine
4.2
6.6
17
41
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.6
406
3247
N76.0
ICD-10 Finland
Acute vaginitis
1.8
6.5
91
516
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
2.4
6.5
44
190
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
2.0
6.3
71
375
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.3
66
340
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
11.1
6.3
11
10
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
11.1
6.3
11
10
EB1VA, ,
NOMESCO Finland
1.7
6.3
133
849
G03CA04
ATC
estriol; systemic, vaginal
2.0
6.3
67
348
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
2.0
6.2
61
307
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
6.1
44
195
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
6.1
86
489
L04AX03
ATC
methotrexate; systemic
1.7
6.1
108
658
8411
FHL
Local change laser, coagulation, biopsy or removal
10.1
6.0
11
11
K50.9
ICD-10 Finland
Crohn disease, unspecified
3.5
6.0
20
58
A02BC02
ATC
pantoprazole; systemic
1.4
6.0
667
5852
C10AC01
ATC
colestyramine; oral
2.7
6.0
32
123
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
118
49
27.08
168.73
3.8
1.5
—
—
—
0
0
620
2489
4.77
133.91
2.9
1.4
—
—
—
0
0
256
554
5.83
117.05
2.9
1.4
—
—
—
0
0
151
799
2.04
13.41
1.7
1.7
—
—
—
0
0
125
617
2.17
13.32
1.7
1.6
—
—
—
0
0
190
1104
1.89
12.82
1.9
1.9
—
—
—
0
0
775
6611
1.71
11.91
5.4
4.1
12.27
11.41
mm/h
1.14
715
6155
202
1228
1.80
11.71
2.1
2.0
—
—
—
0
0
75
319
2.46
11.29
3.5
1.9
—
—
—
0
0
171
1022
1.81
10.41
4.0
4.1
33.11
32.89
%
0.09
108
714
56
215
2.70
10.39
1.5
1.2
1.60
5.92
u/ml
—
5
17
69
305
2.35
9.56
1.5
1.2
5.50
28.02
u/ml
—
7
20
118
647
1.93
9.38
3.2
3.0
10.85
10.23
g/l
0.80
109
605
281
2013
1.55
8.32
2.5
2.1
—
—
—
0
0
490
3990
1.44
7.43
2.8
2.3
79.11
77.87
nmol/l
0.41
440
3646
61
286
2.20
7.40
1.6
1.3
9.28
10.72
u/ml
0.09
17
57
60
280
2.21
7.36
1.6
1.2
8.29
1.93
u/ml
0.60
15
30
36
133
2.77
7.25
11.2
4.8
449.50
149.93
iu/ml
—
10
15
455
3683
1.42
6.99
6.9
5.0
1.22
1.22
mmol/l
0.87
401
3370
149
954
1.66
6.98
7.2
5.5
—
—
—
0
0
430
3459
1.42
6.78
5.8
4.0
36.15
36.22
g/l
0.09
396
3237
26
83
3.19
6.75
1.4
1.1
45.60
76.13
u/ml
—
5
8
502
4163
1.40
6.58
2.7
2.4
—
—
—
0
0
250
1827
1.49
6.53
1.6
1.5
21.25
22.00
nmol/l
0.29
211
1578
512
4289
1.39
6.18
8.6
5.7
29.60
29.28
%
0.29
481
4038
492
4099
1.39
6.11
8.2
5.7
1.22
1.22
mmol/l
0.13
418
3485
506
4243
1.38
6.01
8.4
5.5
56.20
56.49
%
0.23
476
3982
169
1159
1.55
5.92
1.9
1.7
—
—
—
0
0
54
265
2.10
5.89
2.1
2.0
1.40
1.55
g/l
0.57
45
232
20
59
3.44
5.88
1.3
1.2
—
—
—
0
0
116
729
1.67
5.83
6.3
4.3
242.45
254.91
u/l
0.30
108
692
750
6735
1.42
5.77
9.9
6.7
74.64
75.52
u/l
0.32
718
6343
252
1885
1.45
5.76
1.6
1.5
2.23
2.19
g/l
0.13
154
1158
402
3299
1.36
5.25
2.0
1.9
100.03
99.30
pmol/l
0.10
198
1630
110
701
1.64
5.24
3.1
2.0
0.22
0.22
g/l
0.06
104
665
134
902
1.56
5.08
8.5
4.4
1.05
1.05
mmol/l
0.10
125
824
172
1223
1.49
5.06
2.7
2.1
141.04
100.75
ug/g
0.57
126
951
58
311
1.92
4.99
2.1
1.8
—
—
—
0
0
589
5150
1.34
4.92
11.7
8.6
3.79
3.92
e9/l
0.95
528
4539
53
279
1.95
4.82
2.0
1.7
—
—
—
0
0
287
2263
1.37
4.73
1.3
1.3
1.21
1.60
u/ml
0.26
73
609
263
2060
1.37
4.49
2.6
2.1
2.66
2.96
mg/l
1.73
222
1765
84
521
1.67
4.47
11.1
6.6
9.12
8.13
mmol/l
0.83
79
497
345
2822
1.34
4.43
3.3
3.2
23.68
41.46
ng/l
0.60
197
1657
180
1335
1.42
4.22
1.7
1.7
1110.02
1230.38
nmol/l
1.10
139
1019
12
25
4.84
4.19
1.8
1.1
—
—
—
0
0
12
25
4.84
4.19
1.8
1.1
—
—
—
0
0
80
502
1.64
4.08
1.9
1.6
—
—
—
0
0
113
771
1.52
4.05
2.8
3.0
27.91
53.51
u/ml
1.72
108
743
19
69
2.79
4.03
1.4
1.3
—
—
—
0
0
324
2659
1.32
3.99
3.5
2.3
59.63
57.51
u/l
0.20
306
2452
506
4409
1.29
3.98
4.5
3.6
0.00
0.01
estimate
0.80
89
803
171
1270
1.42
3.97
3.4
2.4
1.13
1.12
e6/l
0.01
103
673
13
32
4.10
3.91
1.7
1.2
—
—
—
0
0
501
4369
1.29
3.88
5.9
4.8
0.00
0.00
estimate
0.50
88
814
44
236
1.90
3.84
1.6
1.2
43.22
45.69
u/ml
0.05
12
22
13
33
3.98
3.80
1.7
1.2
—
—
—
0
0
28
127
2.24
3.79
1.5
1.3
—
—
—
0
0
84
545
1.59
3.76
1.7
1.5
—
—
—
0
0
63
380
1.70
3.75
1.6
1.6
—
—
—
0
0
32
155
2.10
3.70
1.9
1.7
—
—
—
0
0
496
4346
1.27
3.60
4.5
3.6
0.00
0.00
estimate
-0.00
91
864
23
99
2.35
3.52
1.7
1.4
—
—
—
0
0
129
931
1.44
3.51
4.1
2.3
6.47
6.02
umol/l
0.12
115
796
25
112
2.26
3.50
1.1
1.2
—
—
—
0
0
6
6
10.05
3.50
4.7
2.0
3.63
4.08
mg/l
—
6
6
23
100
2.33
3.45
1.7
1.4
—
—
—
0
0
23
100
2.33
3.45
1.7
1.4
—
—
—
0
0
22
95
2.34
3.35
2.1
1.9
19.75
23.70
mg/l
—
8
29
147
1096
1.40
3.34
3.2
2.1
2.32
2.43
g/l
1.45
136
1014
23
102
2.28
3.31
1.7
1.4
—
—
—
0
0
284
2341
1.29
3.30
3.4
3.0
6.61
6.85
mmol/l
0.52
233
2013
276
2269
1.30
3.27
5.0
4.0
0.00
0.00
estimate
1.08
86
818
6
7
8.61
3.26
7.5
7.4
—
—
—
0
0
261
2131
1.30
3.25
4.0
2.8
0.33
0.38
e6/l
0.28
201
1565
23
103
2.26
3.24
1.7
1.4
—
—
—
0
0
23
103
2.26
3.24
1.7
1.4
—
—
—
0
0
35
185
1.92
3.23
1.6
1.2
—
—
—
0
0
135
998
1.41
3.22
3.4
2.2
25.00
22.86
%
0.77
121
844
155
1173
1.38
3.22
3.6
2.5
4.64
4.53
e6/l
0.03
86
580
97
679
1.47
3.11
1.2
1.3
132.27
202.40
u/ml
0.75
90
634
14
50
2.82
3.09
1.2
1.1
104.00
88.57
titre
—
5
7
883
8396
1.37
3.08
12.7
10.7
84.38
84.82
ml/min/173m2
0.24
734
6875
526
4695
1.25
3.08
4.9
4.1
6.52
6.51
mmol/l
0.04
492
4327
13
45
2.91
3.03
1.2
1.1
—
—
—
0
0
203
1618
1.32
3.00
3.1
2.4
8.12
8.24
e6/l
0.03
183
1443
14
51
2.77
2.99
1.5
1.9
—
—
—
0
0
349
2983
1.26
2.97
3.1
3.2
2.36
2.36
mmol/l
0.15
293
2675
933
8969
1.45
2.92
15.8
12.6
139.65
139.72
mmol/l
0.36
905
8736
46
275
1.70
2.88
1.6
1.6
0.01
0.07
iu/ml
—
10
42
27
138
1.98
2.77
1.7
1.4
116.25
121.93
u/ml
—
8
31
934
8993
1.43
2.76
16.1
12.6
3.91
3.92
mmol/l
0.26
903
8739
971
9422
1.58
2.76
13.1
9.6
23.62
23.92
u/l
0.24
940
9134
158
1232
1.33
2.72
4.3
2.9
0.80
0.82
mmol/l
1.46
146
1158
64
423
1.55
2.71
1.5
1.3
2.62
1.03
u/ml
—
5
36
10
29
3.47
2.69
1.3
1.2
—
—
—
0
0
284
2395
1.26
2.68
2.4
2.1
106.94
170.90
u/l
1.61
269
2262
16
67
2.41
2.64
1.3
1.3
—
—
—
0
0
276
2329
1.25
2.58
4.1
2.9
28.37
48.84
e6/l
1.06
215
1738
9
25
3.62
2.58
1.2
1.2
—
—
—
0
0
380
3322
1.23
2.56
12.9
11.0
1.15
1.13
inr
0.23
98
1021
493
4427
1.22
2.55
7.8
5.4
9.28
9.93
umol/l
1.39
477
4182
892
8551
1.33
2.48
4.5
4.2
5.67
5.76
mmol/l
1.58
809
7918
923
8895
1.38
2.46
16.3
11.8
17.89
19.67
mg/l
1.01
734
6865
31
175
1.80
2.40
1.6
1.4
—
—
—
0
0
225
1870
1.26
2.38
2.9
2.8
655.66
865.44
ng/l
1.13
190
1564
1006
9879
1.99
2.37
23.4
17.8
267.97
266.25
e9/l
0.37
984
9676
8
22
3.66
2.36
1.6
2.4
—
—
—
0
0
11
39
2.84
2.34
1.7
2.3
45.40
46.12
%
—
5
24
39
240
1.65
2.25
1.4
1.2
—
—
—
0
0
1006
9886
1.95
2.25
23.4
17.8
4.39
4.43
e12/l
2.18
982
9653
105
794
1.36
2.23
1.9
1.7
—
—
—
0
0
152
1215
1.29
2.20
3.4
2.2
13.60
13.59
umol/l
0.01
140
1130
1005
9876
1.90
2.20
23.4
17.8
39.63
39.60
%
0.07
959
9339
104
787
1.36
2.20
1.8
1.7
—
—
—
0
0
1006
9890
1.93
2.18
23.5
17.9
131.99
132.72
g/l
1.20
993
9777
85
624
1.39
2.17
1.4
1.3
25.42
40.63
au/ml
—
5
41
243
2060
1.24
2.15
3.4
2.3
309.75
4484.21
umol/l
6.30
216
1828
263
2254
1.22
2.09
4.0
3.7
12.43
7.55
mg/mmol
0.58
135
1322
219
1842
1.24
2.08
5.3
4.0
1.01
1.02
kg/l
0.23
19
264
181
1492
1.26
2.05
2.6
2.6
2.44
2.44
mmol/l
0.19
156
1323
86
639
1.38
2.05
4.9
3.2
118.56
75.47
ng/l
2.26
76
568
28
163
1.74
2.00
1.6
1.2
—
—
—
0
0
26
149
1.76
1.96
1.4
1.5
2.07
4.84
ug/l
0.92
19
130
14
64
2.20
1.95
1.9
1.3
—
—
—
0
0
14
64
2.20
1.95
1.9
1.3
—
—
—
0
0
14
64
2.20
1.95
1.9
1.3
—
—
—
0
0
5
11
4.56
1.94
1.0
1.1
—
—
—
0
0
109
848
1.32
1.94
2.3
2.1
383.07
375.89
nmol/l
0.15
98
788
207
1744
1.23
1.93
1.6
1.6
25137058.94
35777767.24
pmol/l
0.15
183
1473
16
78
2.07
1.91
2.1
1.5
0.96
0.97
g/l
0.08
16
78
29
174
1.69
1.88
2.9
2.5
—
—
—
0
0
90
685
1.34
1.86
2.6
2.4
30.33
28.02
au/ml
—
6
59
9
200
0.45
1.84
1.2
1.5
—
—
—
0
0
5
12
4.18
1.82
1.0
1.1
—
—
—
0
0
14
66
2.14
1.82
1.9
1.4
—
—
—
0
0
34
216
1.59
1.78
1.4
1.4
26.85
28.79
u/l
0.12
25
180
75
560
1.37
1.77
1.0
1.0
—
—
—
0
0
471
4311
1.17
1.75
3.2
2.8
93.73
81.13
ug/l
1.09
439
4030
9
36
2.51
1.74
1.7
3.2
—
—
—
0
0
8
30
2.68
1.72
1.0
2.0
—
—
—
0
0
8
30
2.68
1.72
2.9
2.2
52.88
48.41
ug/l
—
8
30
8
30
2.68
1.72
1.0
2.0
—
—
—
0
0
7
25
2.81
1.65
1.6
1.0
—
—
—
0
0
90
699
1.32
1.65
3.4
3.2
4.50
4.53
pmol/l
0.13
80
613
7
26
2.70
1.58
1.1
1.2
455.29
366.61
pmol/l
—
7
18
756
7881
0.84
1.58
17.9
14.1
14.79
14.67
%
0.22
744
7744
38
256
1.50
1.57
1.3
1.4
301.76
305.56
ug/g
0.04
25
140
13
64
2.04
1.54
1.2
1.2
—
—
—
0
0
13
64
2.04
1.54
1.2
1.2
—
—
—
0
0
53
384
1.40
1.52
1.4
1.3
170.29
229.22
miu/ml
0.60
28
192
208
1799
1.20
1.50
1.4
1.3
9.69
12.42
u/ml
0.26
80
731
5
16
3.13
1.44
1.6
2.6
—
—
—
0
0
17
95
1.80
1.43
2.2
1.5
21.98
45.49
u/ml
0.24
17
95
13
67
1.95
1.38
1.0
1.0
—
—
—
0
0
37
256
1.46
1.37
1.1
1.1
—
—
—
0
0
5
17
2.95
1.36
1.4
2.7
16.80
20.61
umol/l
—
5
17
24
151
1.60
1.35
1.5
1.3
—
—
—
0
0
24
151
1.60
1.35
1.5
1.3
—
—
—
0
0
903
8790
1.23
1.35
4.4
4.1
4.90
4.89
mmol/l
0.12
833
8287
14
75
1.88
1.34
1.9
1.4
—
—
—
0
0
10
47
2.14
1.34
1.0
1.0
—
—
—
0
0
369
3372
1.15
1.32
4.6
3.7
—
—
—
0
0
915
8928
1.23
1.28
4.8
4.5
2.90
2.90
mmol/l
0.00
835
8358
12
62
1.95
1.28
1.0
1.1
300.83
296.02
mg/l
0.12
12
54
76
602
1.28
1.25
6.2
2.8
1.31
2.09
mmol/l
1.15
67
506
119
994
1.22
1.24
1.9
1.6
1.29
1.35
%
0.65
103
893
51
384
1.35
1.20
3.8
3.2
1.49
1.92
mmol/l
0.39
37
293
17
101
1.69
1.20
2.1
2.2
—
—
—
0
0
39
281
1.40
1.20
1.1
1.1
1.60
5.49
u/ml
—
6
40
636
6049
1.14
1.19
3.6
2.8
46.62
39.05
u/l
0.80
602
5698
11
58
1.91
1.12
1.3
1.2
—
—
—
0
0
24
160
1.51
1.10
1.2
1.2
1.43
1.83
u/ml
—
7
47
820
7951
1.16
1.09
5.3
5.1
38.14
38.85
mmol/mol
1.86
747
7452
64
507
1.28
1.08
2.5
2.2
4.12
6.32
ug/l
1.22
51
452
52
401
1.31
1.07
4.0
3.3
5.07
5.16
kpa
0.51
47
390
70
563
1.26
1.05
2.5
2.7
67.30
67.50
g/l
0.07
59
526
55
429
1.30
1.05
1.8
1.5
—
—
—
0
0
85
700
1.23
1.04
2.4
2.3
67.29
71.84
ml/min/173m2
0.36
31
272
46
350
1.33
1.04
1.2
1.5
148.04
189.18
pmol/l
0.21
46
343
228
2047
1.15
1.04
1.6
1.5
—
—
—
0
0
9
46
1.96
1.03
2.9
1.7
1.25
1.33
nmol/l
—
9
40
7
34
2.07
1.03
1.0
1.3
—
—
—
0
0
9
47
1.92
1.02
1.2
1.1
—
—
—
0
0
30
214
1.41
1.00
1.2
1.7
38.02
38.18
g/l
0.05
25
197
232
2091
1.14
1.00
1.7
1.7
0.92
0.90
mg/l
0.07
171
1587
36
266
1.37
0.99
1.3
1.3
—
—
—
0
0
207
1853
1.15
0.99
1.4
1.3
22.34
28.27
iu/ml
0.67
64
645
322
2966
1.12
0.99
4.4
2.8
30.56
29.57
u/l
0.23
311
2837
15
236
0.63
0.98
1.5
1.7
—
—
—
0
0
5
23
2.18
0.98
1.0
1.0
—
—
—
0
0
19
124
1.54
0.97
1.1
1.1
—
—
—
0
0
34
251
1.37
0.95
1.7
1.9
8.89
10.06
g/l
1.67
29
233
51
401
1.29
0.94
3.8
2.6
125.57
127.90
g/l
0.40
51
390
10
55
1.83
0.92
1.2
1.2
28.79
29.74
nmol/l
—
10
39
19
127
1.51
0.89
1.7
1.4
—
—
—
0
0
19
127
1.51
0.89
1.7
1.4
—
—
—
0
0
7
129
0.54
0.88
3.1
6.1
281.14
379.04
umol/l
—
7
112
18
120
1.51
0.85
1.1
1.3
—
—
—
0
0
661
6367
1.11
0.84
3.3
3.3
—
—
—
0
0
34
258
1.33
0.82
2.7
1.9
2.86
2.94
g/l
0.22
29
241
892
8749
1.15
0.79
4.4
4.1
1.58
1.58
mmol/l
0.01
812
8208
16
106
1.52
0.79
2.8
3.3
0.77
0.84
nmol/l
—
10
86
8
48
1.67
0.79
1.1
1.3
—
—
—
0
0
35
269
1.31
0.78
2.7
1.9
3.61
3.62
g/l
0.01
30
253
31
234
1.33
0.78
2.1
2.0
0.61
0.49
g/l
0.07
26
213
33
252
1.32
0.77
3.0
2.9
17.56
680.53
u/ml
0.66
25
219
35
270
1.31
0.77
2.7
1.9
7.49
7.49
g/l
0.01
30
253
35
270
1.31
0.77
2.7
1.9
—
—
—
0
0
46
569
0.80
0.76
1.2
1.5
—
—
—
0
0
49
396
1.25
0.75
2.2
2.1
43.73
39.34
u/l
0.83
43
354
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
167
1.39
0.74
3.7
3.1
0.26
0.37
u/ml
—
10
91
22
160
1.38
0.70
1.0
1.2
2.38
4.75
u/ml
—
8
56
18
126
1.44
0.70
1.1
1.3
—
—
—
0
0
20
143
1.41
0.70
1.9
1.7
—
—
—
0
0
13
85
1.54
0.69
1.4
1.4
—
—
—
0
0
13
85
1.54
0.69
1.4
1.4
—
—
—
0
0
778
7589
1.10
0.68
4.7
4.5
14.55
14.54
pmol/l
0.02
718
7069
67
567
1.19
0.68
1.8
1.5
—
—
—
0
0
7
42
1.67
0.68
2.1
1.3
—
—
—
0
0
7
42
1.67
0.68
2.1
1.3
—
—
—
0
0
36
285
1.27
0.67
1.3
1.2
—
—
—
0
0
36
285
1.27
0.67
1.3
1.2
—
—
—
0
0
18
129
1.40
0.63
1.8
1.5
—
—
—
0
0
858
8425
1.11
0.61
4.0
3.7
1.27
1.24
mmol/l
0.70
770
7854
5
30
1.67
0.61
2.4
1.4
—
—
—
0
0
5
30
1.67
0.61
2.4
1.4
—
—
—
0
0
5
30
1.67
0.61
2.4
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.8
—
5.78
—
0
13
15
105
1.43
0.60
2.3
1.7
61.20
60.95
%
0.01
15
105
21
157
1.34
0.59
1.1
1.1
—
—
—
0
0
6
35
1.72
0.57
1.0
1.0
—
—
—
0
0
34
274
1.25
0.57
1.3
1.2
—
—
—
0
0
875
8613
1.11
0.55
5.5
5.2
1.75
1.96
mu/l
0.83
805
8073
12
82
1.47
0.54
1.3
1.1
—
—
—
0
0
6
38
1.58
0.54
2.5
3.3
4568.33
850.79
u/ml
—
6
38
9
63
1.43
0.52
2.8
2.1
—
—
—
0
0
85
756
1.14
0.50
6.8
7.0
0.72
1.31
mmol/l
0.95
64
603
6
41
1.47
0.50
2.3
2.2
23.67
213.72
ug/l
—
6
36
11
76
1.45
0.48
1.0
1.1
—
—
—
0
0
11
76
1.45
0.48
1.0
1.1
—
—
—
0
0
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
11
77
1.43
0.45
1.0
1.1
—
—
—
0
0
11
77
1.43
0.45
1.0
1.1
—
—
—
0
0
11
77
1.43
0.45
1.5
1.6
—
—
—
0
0
11
77
1.43
0.45
1.0
1.1
—
—
—
0
0
22
275
0.80
0.45
1.2
1.5
—
—
—
0
0
88
792
1.12
0.44
3.6
2.2
94.09
37.81
u/l
0.67
78
661
67
755
0.88
0.44
1.4
1.3
35.05
29.63
iu/l
0.53
55
644
18
139
1.30
0.44
1.2
1.2
—
—
—
0
0
15
196
0.76
0.43
2.2
1.6
—
—
—
0
0
5
31
1.62
0.43
1.8
1.4
7.89
8.39
ug/l
—
5
31
85
941
0.89
0.42
1.9
1.6
—
—
—
0
0
28
338
0.82
0.42
1.3
1.5
—
—
—
0
0
33
391
0.84
0.41
1.2
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.21
—
0
9
37
315
1.18
0.40
4.4
2.8
25.18
25.74
mmol/l
0.69
37
305
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
84
760
1.11
0.40
6.9
7.0
14.48
12.80
kpa
1.19
78
731
84
760
1.11
0.40
6.9
7.0
5.07
5.13
kpa
0.25
79
734
9
67
1.35
0.38
1.2
1.4
1.59
1.64
g/l
—
9
67
27
321
0.84
0.36
1.2
1.4
—
—
—
0
0
27
321
0.84
0.36
1.2
1.4
—
—
—
0
0
27
320
0.84
0.35
1.2
1.4
—
—
—
0
0
27
320
0.84
0.35
1.2
1.4
—
—
—
0
0
6
43
1.40
0.35
1.5
1.3
—
68.00
—
0
5
40
349
1.15
0.34
1.5
1.8
—
—
—
0
0
8
63
1.27
0.27
3.1
3.8
—
—
—
0
0
83
769
1.09
0.27
3.9
3.8
3.12
14.82
ug/l
1.24
67
604
13
104
1.25
0.26
1.3
1.5
—
—
—
0
0
9
77
1.17
0.24
1.0
1.1
—
—
—
0
0
6
81
0.74
0.24
1.2
1.6
—
—
—
0
0
12
146
0.82
0.22
2.0
2.2
15.72
16.47
%
—
6
71
14
116
1.21
0.22
1.4
1.1
—
—
—
0
0
5
41
1.22
0.22
1.2
1.7
115.20
85.28
nmol/24h
—
5
41
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
2.6
2.4
42200.00
37247.63
ug/l
—
5
43
21
183
1.15
0.20
1.6
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
1.20
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
13
155
0.84
0.20
2.2
2.4
53.40
97.90
ug/min
—
8
103
52
481
1.09
0.19
2.0
2.0
1089.69
3250.10
u/l
0.99
16
192
11
90
1.22
0.19
1.5
1.5
—
—
—
0
0
16
137
1.17
0.19
2.6
2.1
8.92
5.25
umol/l
—
10
91
137
1426
0.95
0.18
3.2
3.3
207.45
337.23
ng/l
0.54
92
950
15
174
0.86
0.18
3.4
3.6
4.21
4.14
e9/l
0.04
15
174
8
70
1.14
0.16
1.0
1.4
—
—
—
0
0
7
86
0.81
0.14
2.4
1.3
1.16
1.60
nmol/l
—
7
73
13
112
1.16
0.14
1.1
1.1
99.54
95.02
%
0.47
13
106
75
785
0.95
0.13
3.2
3.0
—
—
—
0
0
11
94
1.17
0.13
1.4
1.4
—
—
—
0
0
16
179
0.89
0.12
3.5
3.9
58.94
58.17
%
0.07
16
179
27
290
0.93
0.10
2.1
2.0
2.85
5.27
iu/l
1.74
11
114
67
697
0.96
0.10
4.0
3.3
1.23
1.23
mmol/l
0.29
62
604
5
44
1.14
0.10
1.4
1.1
83.60
474.00
u/l
—
5
38
53
507
1.05
0.09
2.8
2.7
106.64
152.06
ng/l
1.43
47
467
19
175
1.09
0.08
1.8
1.5
—
—
—
0
0
7
65
1.08
0.08
1.9
1.3
63.14
69.80
umol/l
—
7
65
9
85
1.06
0.07
1.0
1.1
—
—
—
0
0
15
163
0.92
0.07
1.1
1.1
—
—
—
0
0
14
128
1.10
0.06
1.4
1.4
—
—
—
0
0
12
132
0.91
0.06
1.4
1.6
—
—
—
0
0
9
103
0.87
0.06
1.0
1.1
—
—
—
0
0
240
2372
1.02
0.06
1.7
1.6
1.35
1.34
mmol/l
0.04
208
2046
14
151
0.93
0.05
1.1
1.1
120.29
119.35
%
0.04
14
141
82
838
0.98
0.05
1.2
1.2
90.13
153.67
iu/ml
1.62
30
345
15
161
0.93
0.05
1.5
2.0
130.38
130.97
g/l
—
8
118
20
211
0.95
0.04
1.3
1.5
61.07
10.43
e6/l
0.66
14
168
20
211
0.95
0.04
1.3
1.5
241.57
378.37
e6/l
0.19
14
176
35
362
0.97
0.04
1.5
1.7
—
—
—
0
0
19
200
0.95
0.03
1.4
1.4
—
—
—
0
0
17
161
1.06
0.03
1.1
1.0
2.96
2.67
u/ml
—
7
76
21
201
1.05
0.03
1.1
1.1
0.42
2.02
u/ml
—
8
104
12
112
1.07
0.03
1.0
1.1
—
—
—
0
0
22
212
1.04
0.02
1.5
1.6
—
—
—
0
0
10
102
0.98
0.00
1.0
1.1
—
—
—
0
0
11
112
0.98
0.00
1.5
1.4
—
—
—
0
0
34
339
1.00
0.00
2.1
1.8
—
—
—
0
0
43
435
0.99
0.00
1.5
1.8
2.22
4.55
mg/l
1.02
33
317
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
57
0.88
0.00
1.4
1.8
—
—
—
0
0
5
57
0.88
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
-0.00
2.0
1.7
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
6.46
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint N14_VAGINAL_DYSPLASIA_ALL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VAGINAL_DYSPLASIA_ALL | 1.242 [1.1, 1.41] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.289 |
During the follow-up period (1.1.1998 — 31.12.2019), 449 out of 4114 females with N14_VAGINAL_DYSPLASIA_ALL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VAGINAL_DYSPLASIA_ALL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.054% | No data |
| 5 | 0.636% | No data |
| 10 | 1.703% | No data |
| 15 | 3.337% | No data |
| 20 | 6.267% | No data |
Relationships between endpoints
↥Index endpoint: N14_VAGINAL_DYSPLASIA_ALL – All dysplastic lesions of the vagina
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data