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Carcinoma in situ of cervix uteri, exocervix

CD2_INSITU_CERVIX_UTERI_EXOCERVIX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06.1&
  • Cause of death: ICD-10 D06.1&

2 out of 7 registries used, show all original rules.

259

4. Check minimum number of events

None

259

5. Include endpoints

None

259

6. Filter based on genotype QC (FinnGen only)

259

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D06
Name in latin
Carcinoma in situ exocervicis (uteri)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 259 259 -
Unadjusted period prevalence (%) 0.09 0.09 -
Median age at first event (years) 35.48 35.48 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
243
Matched controls
2429
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
+∞
323.0
243
*
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
398.3
118.3
110
5
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
31.8
101.1
144
106
ULA02
NOMESCO Finland
Kolposcopy
21.7
95.8
175
257
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
19.5
90.5
175
283
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
215.7
64.5
64
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
20.3
49.7
77
54
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
10.4
49.0
111
181
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
6.4
35.3
116
302
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
21.6
33.1
49
28
LDA10
NOMESCO Finland
Curettage of cervix uteri
10.2
32.5
69
91
ZXC00
NOMESCO Finland
Use of diathermy
50.8
29.6
35
8
N87.1
ICD-10 Finland
Moderate cervical dysplasia
13.1
23.5
42
38
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
252.7
23.0
23
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
7.3
16.5
41
66
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
159.1
14.6
15
*
LCD10
NOMESCO Finland
Vaginal hysterectomy
7.4
13.3
32
49
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
57.3
9.7
11
*
N87.0
ICD-10 Finland
Mild cervical dysplasia
5.8
9.7
27
51
LEB00
NOMESCO Finland
Biopsy of vagina
11.3
9.4
17
16
8010/2-C53.9
ICD-O-3
Carcinoma in situ, NOS, of cervix uteri
+∞
9.4
9
*
G01AA10
ATC
clindamycin; vaginal
2.6
9.3
87
435
C539, 6666, 0
ICD-O-3
NA
8.1
8.8
19
25
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.8
8.5
60
252
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
93.1
8.5
9
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
5.1
8.4
26
56
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
4.6
8.2
28
67
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
27.4
6.3
8
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_EXOCERVIX – Carcinoma in situ of cervix uteri, exocervix

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).