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Carcinoma in situ of cervix uteri, endocervix

CD2_INSITU_CERVIX_UTERI_ENDOCERVIX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06.0&
  • Cause of death: ICD-10 D06.0&

2 out of 7 registries used, show all original rules.

438

4. Check minimum number of events

None

438

5. Include endpoints

None

438

6. Filter based on genotype QC (FinnGen only)

438

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D06
Name in latin
Carcinoma in situ endocervicis (uteri)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 438 438 -
Unadjusted period prevalence (%) 0.15 0.15 -
Median age at first event (years) 38.86 38.86 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
381
Matched controls
3810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
+∞
323.0
381
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
63.7
225.5
273
145
ULA02
NOMESCO Finland
Kolposcopy
34.8
189.0
299
361
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
33.6
186.2
302
388
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
1915.2
140.9
128
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
16.9
129.9
269
474
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
19.2
124.1
215
240
LDA10
NOMESCO Finland
Curettage of cervix uteri
21.2
102.3
161
127
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
24.2
85.8
126
76
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
459.4
77.8
75
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
25.3
69.2
99
52
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
191.5
63.1
64
*
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
132.1
34.3
36
*
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
326.9
30.2
30
*
8140/2-C53.0
ICD-O-3
Adenocarcinoma in situ, NOS, of endocervix
+∞
27.4
26
*
8140/2-C53.1
ICD-O-3
Adenocarcinoma in situ, NOS, of exocervix
+∞
26.4
25
*
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
7.5
25.5
63
98
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
255.3
23.9
24
*
N87.1
ICD-10 Finland
Moderate cervical dysplasia
8.5
23.6
53
71
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
7.5
22.5
55
84
LEB00
NOMESCO Finland
Biopsy of vagina
11.3
21.2
40
39
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
9.2
20.8
44
53
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.6
17.7
217
1287
ZXC00
NOMESCO Finland
Use of diathermy
22.2
17.5
25
12
LCD10
NOMESCO Finland
Vaginal hysterectomy
7.7
17.4
41
59
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
31.6
16.3
21
7
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
47.0
15.2
18
*
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
83.4
14.7
16
*
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
155.7
14.6
15
*
LCA06
NOMESCO Finland
Biopsy of endometrium
2.8
13.9
101
431
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
+∞
13.6
13
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.7
12.5
99
442
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
4.8
12.1
40
90
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
13.1
11.8
20
16
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
31.1
11.7
15
5
C53.12
ICD-10 Finland
Adenocarcinoma of the exocervix
123.6
11.5
12
*
C539, 6666, 0
ICD-O-3
NA
9.3
11.4
23
26
A63.0
ICD-10 Finland
Anogenital (venereal) warts
4.4
11.2
41
102
N87.0
ICD-10 Finland
Mild cervical dysplasia
5.0
11.1
35
75
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
33.5
10.4
13
*
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
7.0
10.1
24
36
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
11.0
9.9
18
17
C53.01
ICD-10 Finland
Squamous cell carcinoma of the endocervix
56.5
9.7
11
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
102.5
9.5
10
*
ZXC96
NOMESCO Finland
Robot assisted procedure
11.1
8.9
16
15
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.9
8.5
34
93
8140/3-C53.0
ICD-O-3
Adenocarcinoma, NOS, of endocervix
92.0
8.4
9
*
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
+∞
8.4
8
*
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
34.1
8.1
10
*
WX402
NOMESCO Finland
General anaesthesia
2.2
8.1
86
439
G01AA10
ATC
clindamycin; vaginal
2.1
7.9
107
605
C53.00
ICD-10 Finland
Malignant tumor of endocervix without histology
81.6
7.4
8
*
B01AB05
ATC
enoxaparin; parenteral
1.9
6.8
105
622
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
4.7
6.6
21
47
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.2
6.5
32
105
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
8.4
6.4
13
16
B01AB10
ATC
tinzaparin; parenteral
3.1
6.3
32
108
8010/2-C53.9
ICD-O-3
Carcinoma in situ, NOS, of cervix uteri
+∞
6.3
6
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_ENDOCERVIX – Carcinoma in situ of cervix uteri, endocervix

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).