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Drug-induced systemic lupus erythematosus

EFO Endpoint Browser PheWeb

DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M32.0#

1 out of 7 registries used, show all original rules.

242

4. Check minimum number of events

None

242

5. Include endpoints

None

242

6. Filter based on genotype QC (FinnGen only)

237

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1257 1021 229
Only index persons 1098 918 180
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 52.81 51.34 58.87
Only index persons 50.83 49.95 55.29

-FinnGen-

Key figures

All Female Male
Number of individuals 237 199 38
Unadjusted period prevalence (%) 0.06 0.07 0.02
Median age at first event (years) 46.87 46.11 50.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
242
Matched controls
2420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
307.7
241
*
P01BA02
ATC
hydroxychloroquine; oral
57.2
231.4
185
130
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
986.7
222.1
186
8
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
35.9
185.2
174
161
L04AX01
ATC
azathioprine; systemic
40.6
150.2
101
42
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
763.5
103.9
95
*
L04AA06
ATC
mycophenolic acid; systemic
45.6
96.1
59
17
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
1342.9
95.8
87
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
46.1
88.6
54
15
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
16.0
88.1
91
88
H02AB07
ATC
prednisone; oral
10.0
70.2
113
195
M05BA04
ATC
alendronic acid; oral
11.5
63.7
80
100
L04AX03
ATC
methotrexate; systemic
8.6
52.5
85
143
M32
ICD-10 Finland
Systemic lupus erythematosus
606.5
51.4
49
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
16.5
50.8
46
34
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.3
49.1
173
618
L01BA01
ATC
methotrexate; systemic
15.6
48.2
45
35
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.5
44.4
68
106
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
178.3
43.4
44
*
H02AB06
ATC
prednisolone; systemic
8.0
42.7
198
870
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.9
41.7
69
117
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
402.4
36.0
35
*
C08CA05
ATC
nifedipine; systemic
9.3
35.8
48
63
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.4
34.4
58
99
L93.0
ICD-10 Finland
Discoid lupus erythematosus
86.7
33.9
37
5
L88
ICPC
Rheumatoid/seropositive arthritis
10.1
31.0
38
44
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
31.0
165
739
TPH04
NOMESCO Finland
Cathetrisation of vein
4.8
30.6
101
315
B01AA03
ATC
warfarin; systemic
5.3
27.2
68
167
R50.9
ICD-10 Finland
Fever, unspecified
4.8
26.0
75
207
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
277.5
25.2
25
*
ZX120
NOMESCO Finland
Intravenous
5.5
24.6
56
126
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
23.2
61
155
M05BA07
ATC
risedronic acid; oral
9.8
22.9
28
32
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
22.2
21
*
C03CA01
ATC
furosemide; systemic
3.8
22.2
98
365
M35.1
ICD-10 Finland
Other overlap syndromes
66.2
21.3
24
*
L04AA01
ATC
[U] ciclosporin
46.2
20.9
25
6
H02AB04
ATC
methylprednisolone; systemic
4.2
20.5
69
211
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
6.2
20.2
38
71
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
20.1
19
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
18.4
107
466
E000001, ,
ATC
3.5
17.9
83
313
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.3
17.3
51
140
A07AA02
ATC
nystatin; oral
5.4
17.2
37
78
Z01.8
ICD-10 Finland
Other specified special examinations
3.4
17.2
87
345
D07AB08
ATC
desonide; topical
4.0
16.9
57
173
D68.8
ICD-10 Finland
Other specified coagulation defects
19.7
16.9
25
14
N02AX02
ATC
tramadol; systemic, rectal
3.1
16.4
143
773
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
16.2
55
167
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
16.1
77
294
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.4
15.1
23
34
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
15.1
62
214
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.2
15.0
27
48
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
38.7
14.7
18
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
14.6
44
122
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.2
14.5
76
304
A02BC02
ATC
pantoprazole; systemic
3.6
13.7
200
1381
J01MA12
ATC
levofloxacin; systemic
3.2
13.7
69
269
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.8
13.6
143
827
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
13.0
56
198
A02BC03
ATC
lansoprazole; oral
2.7
12.9
102
507
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.7
12.8
46
144
L04AD01
ATC
ciclosporin; systemic
14.2
12.7
21
16
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.6
12.5
25
49
R4120
NOMESCO Finland
Occupational therapy
4.2
12.4
36
97
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.7
12.4
44
137
B01AB05
ATC
enoxaparin; parenteral
2.7
12.2
105
541
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.2
11.7
25
52
M05BX04
ATC
denosumab; parenteral
4.6
11.6
29
69
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.9
11.5
27
61
E0000UV, ,
ATC
2.5
11.4
133
786
J01MA14
ATC
moxifloxacin; systemic
3.7
11.4
39
118
XX9XE
NOMESCO Finland
Other ultrasound examination
18.2
11.4
17
10
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.0
11.3
34
94
J01FF01
ATC
clindamycin; systemic
2.6
11.3
94
474
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
10.9
40
127
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
10.8
30
78
J05AB01
ATC
aciclovir; systemic
2.6
10.6
88
440
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.1
10.5
31
84
Z50.1
ICD-10 Finland
Other physical therapy
4.6
10.4
26
62
P01BA01
ATC
chloroquine; systemic
24.6
10.4
14
6
J01MA02
ATC
ciprofloxacin; systemic
2.4
10.1
112
637
A02BC01
ATC
omeprazole; systemic
2.5
10.0
89
458
B01AB04
ATC
dalteparin; parenteral
5.0
10.0
22
47
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.7
9.9
33
98
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.6
9.8
72
338
B07.9
ICD-10 Finland
Verruca simplex
7.7
9.8
22
31
AA1AD
NOMESCO Finland
CT of head and brain
2.5
9.7
80
396
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
9.5
21
45
Z3231
NOMESCO Finland
Registered nurse
2.4
9.4
87
453
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.9
9.4
29
81
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
+∞
9.4
9
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.1
9.2
44
164
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.5
9.1
23
55
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.8
9.1
30
88
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.6
9.1
22
51
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.1
9.1
26
69
H26.3
ICD-10 Finland
Drug-induced cataract
25.1
9.0
12
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
9.0
47
184
205
Kela drug reimbursment
Chronic hypertension
2.6
8.9
66
310
318
Kela drug reimbursment
Teriparatide
51.9
8.7
10
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
8.7
39
140
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
17.1
8.6
13
8
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
17.1
8.6
13
8
SAA03
NOMESCO Finland
Extended examination of mouth
2.2
8.6
120
740
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.0
8.6
25
67
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
8.6
36
124
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
8.4
8.5
18
23
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
8.5
32
103
J01FA06
ATC
roxithromycin; oral
2.2
8.5
126
796
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
6.9
8.4
20
31
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.5
8.4
21
50
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
8.4
8
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
8.0
8.3
18
24
J02AC01
ATC
fluconazole; systemic
2.2
8.1
138
913
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
22.9
8.1
11
5
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
22.9
8.1
11
5
C08CA02
ATC
felodipine; oral
3.7
8.1
27
80
B02.9
ICD-10 Finland
Zoster without complication
3.5
8.0
29
91
R06.0
ICD-10 Finland
Dyspnoea
2.3
7.9
80
429
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.8
7.9
19
30
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
7.9
84
461
L99
ICPC
Musculoskeletal disease other
7.9
7.8
17
23
XCK00
NOMESCO Finland
Perimetry
3.9
7.8
24
67
H05AA02
ATC
teriparatide; parenteral
46.5
7.8
9
*
N32.9
ICD-10 Finland
Bladder disorder, unspecified
46.5
7.8
9
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
9.3
7.7
15
17
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
7.7
40
156
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
7.6
36
133
C09AA02
ATC
enalapril; systemic
2.6
7.5
51
228
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.6
7.5
47
202
J05AB11
ATC
valaciclovir; oral
2.5
7.5
57
269
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
7.5
57
269
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.3
7.4
29
95
D07AC01
ATC
betamethasone; topical
2.1
7.4
104
633
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
7.4
38
147
Z3226
NOMESCO Finland
Physiotherapist
2.4
7.4
61
299
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
7.3
99
593
R4110
NOMESCO Finland
Physiotherapy
2.2
7.3
85
480
Z2221
NOMESCO Finland
Medical doctor
2.2
7.3
87
496
N05.8
ICD-10 Finland
Unspecified nephritic syndrome, other
+∞
7.3
7
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
7.3
39
154
C08CA01
ATC
amlodipine; oral
2.1
7.2
96
571
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
7.2
40
161
M05BA01
ATC
etidronic acid; systemic
20.8
7.2
10
5
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
12.5
7.2
12
10
L95
ICPC
Osteoporosis
4.4
7.1
18
43
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.5
7.1
13
13
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
7.0
58
283
M13.9
ICD-10 Finland
Arthritis, unspecified
3.3
7.0
28
93
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
7.0
37
145
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.9
6.9
21
58
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
41.2
6.8
8
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
6.8
91
541
ULA02
NOMESCO Finland
Kolposcopy
2.6
6.8
42
179
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
6.8
6.8
16
25
I50.9
ICD-10 Finland
Heart failure, unspecified
2.9
6.7
32
119
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
6.6
29
102
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.2
6.6
15
22
L04AA13
ATC
[U] leflunomide
7.2
6.6
15
22
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.6
107
680
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.4
6.6
12
12
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.0
6.6
30
108
N03AX14
ATC
levetiracetam; systemic
6.5
6.6
16
26
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
6.5
115
752
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
6.4
41
177
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
6.4
40
171
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
6.4
46
211
EBA10
NOMESCO Finland
Operative extraction of tooth
2.6
6.3
39
166
JN4AD
NOMESCO Finland
Body CT examination
2.9
6.3
30
111
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
4.2
6.3
17
43
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
6.3
6
*
7108X
ICD-9 Finland
Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue
+∞
6.3
6
*
N18.0
ICD-10 Finland
End-stage renal disease
27.5
6.3
8
*
1XC02, ,
NOMESCO Finland
27.5
6.3
8
*
M01AH02
ATC
rofecoxib; oral
2.5
6.3
42
186
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.0
6.2
28
100
A02BA02
ATC
ranitidine; systemic
2.2
6.2
60
312
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.0
6.2
18
48
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
4.3
6.2
16
39
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.4
6.2
46
214
SAA04
NOMESCO Finland
Special examination of mouth
3.7
6.2
20
58
L28
ICPC
Limited function/disability (L)
2.4
6.1
49
235
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.3
6.1
15
25
N18.8
ICD-10 Finland
Other chronic renal failure
10.4
6.1
11
11
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.9
6.1
30
113
J01MA01
ATC
ofloxacin; systemic
3.0
6.0
28
102

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
66
17.61
84.91
1.8
1.3
19.58
2.88
u/ml
—
25
10
79
67
17.02
82.40
1.8
1.3
11.21
8.99
u/ml
0.13
31
15
80
71
16.34
81.18
1.8
1.3
30.49
1.22
u/ml
—
15
5
136
307
8.83
65.86
2.8
1.4
745.26
540.27
titre
0.88
95
75
73
86
11.72
60.53
1.9
1.3
0.90
2.04
u/ml
—
8
5
58
59
12.61
52.88
1.7
1.3
49.90
34.46
u/ml
—
21
9
43
39
13.19
41.84
1.8
1.1
7.69
5.29
u/ml
0.28
26
14
35
22
18.43
41.72
1.7
1.2
—
—
—
0
0
203
960
7.92
38.79
18.7
6.2
—
—
—
0
0
208
1016
8.45
38.01
17.8
5.5
0.58
0.54
e9/l
1.32
200
894
208
1018
8.43
37.86
17.8
5.5
0.04
0.04
e9/l
0.49
200
895
209
1044
8.35
36.65
17.9
5.5
1.65
1.92
e9/l
2.32
203
941
209
1058
8.15
35.66
18.4
5.7
0.15
0.18
e9/l
1.92
204
943
66
144
5.93
30.42
6.1
4.0
0.29
0.93
%
1.48
31
45
211
1194
6.99
28.28
21.1
9.1
3.59
3.95
e9/l
2.06
204
1056
175
882
4.55
26.48
3.6
2.3
80.75
77.29
nmol/l
0.89
169
796
62
146
5.36
25.99
6.8
4.2
0.00
0.21
%
1.74
28
42
65
161
5.15
25.67
6.7
4.0
0.61
1.05
%
0.98
31
57
178
943
4.36
24.25
12.6
5.9
1.22
1.22
mmol/l
0.25
162
801
59
141
5.21
24.21
6.8
4.2
0.04
0.18
%
0.39
23
39
81
253
4.31
23.72
4.1
2.2
2.20
2.50
g/l
4.16
81
232
104
393
3.89
23.21
4.6
2.3
3.96
7.38
e6/l
0.98
96
357
129
565
3.75
23.01
7.1
2.9
18.98
151.94
e6/l
0.61
107
432
99
369
3.85
22.43
6.8
2.5
497.99
521.26
mosm/kgh2o
0.58
89
317
121
516
3.69
22.34
7.0
2.7
0.14
0.41
e6/l
1.81
100
381
143
680
3.70
22.27
8.8
3.5
66.92
73.40
e6/l
0.05
113
468
76
238
4.20
22.01
4.3
2.3
21.63
22.49
%
0.21
68
202
120
518
3.61
21.58
6.0
2.6
—
—
—
0
0
109
450
3.59
20.88
6.1
3.7
—
—
—
0
0
81
284
3.78
19.75
4.1
2.2
11.50
14.10
umol/l
2.49
81
262
179
1032
3.82
19.70
11.2
4.6
0.00
0.00
estimate
-0.00
39
195
63
188
4.18
19.26
4.2
3.1
1.63
1.75
%
0.52
63
177
177
1024
3.71
19.13
7.6
3.4
0.00
0.00
estimate
-0.00
42
210
154
823
3.40
18.84
6.4
3.2
5.96
5.83
ph
0.17
12
72
25
32
8.60
18.64
1.9
1.3
—
—
—
0
0
178
1044
3.67
18.59
7.8
3.4
0.00
0.00
estimate
-0.00
37
188
51
137
4.45
17.83
1.7
1.7
1.17
1.41
g/l
0.38
46
127
210
1421
4.61
16.62
11.9
4.0
—
—
—
0
0
148
816
3.09
16.34
8.1
3.9
34.47
36.26
g/l
3.88
143
772
48
134
4.22
15.87
3.3
2.9
64.13
73.19
e9/l
0.98
34
106
42
107
4.54
15.62
1.8
2.2
—
—
—
0
0
23
35
7.16
14.75
1.3
1.5
—
—
—
0
0
116
594
2.83
14.10
8.2
3.7
7.38
7.40
ph
2.28
22
111
96
450
2.88
13.72
6.0
3.5
—
—
—
0
0
96
452
2.86
13.59
4.1
2.1
2.92
3.20
mg/l
0.46
90
386
118
619
2.77
13.56
3.2
2.8
—
—
—
0
0
22
35
6.81
13.53
1.2
2.0
—
—
—
0
0
69
278
3.07
12.87
2.9
2.0
—
—
—
0
0
151
918
2.71
12.65
19.7
8.2
0.00
0.00
e9/l
0.06
136
747
69
283
3.01
12.43
6.9
2.7
1.92
3.31
e6/l
0.90
41
144
213
1570
3.98
12.31
14.3
4.0
15.44
10.95
mm/h
5.10
207
1453
139
841
2.53
11.30
31.0
10.4
1.48
1.17
inr
2.08
39
247
55
216
3.00
10.56
2.5
1.5
—
—
—
0
0
91
470
2.50
10.18
2.9
1.8
1.29
0.91
mg/l
0.75
78
356
101
556
2.40
9.74
7.1
3.5
22.22
9.49
mg/mmol
1.04
79
320
15
10
15.89
9.65
1.9
2.4
0.03
0.22
e9/l
—
15
10
39
133
3.30
9.44
15.0
6.3
—
—
—
0
0
12
5
25.13
9.00
1.8
1.8
—
—
—
0
0
29
84
3.79
8.96
1.3
1.2
—
—
—
0
0
101
576
2.29
8.79
5.3
2.8
6.24
7.31
mmol/l
2.16
95
486
20
29
7.42
8.75
2.5
3.1
0.70
1.98
%
1.20
20
24
22
54
4.38
8.46
2.7
2.5
—
—
—
0
0
11
5
22.94
8.09
1.5
2.0
—
—
—
0
0
93
529
2.23
7.99
5.4
3.0
122.74
317.85
mg/l
0.52
69
320
13
10
13.65
7.97
1.5
1.3
—
—
—
0
0
13
10
13.65
7.97
1.5
1.2
—
—
—
0
0
19
44
4.60
7.83
5.5
3.7
62.16
62.23
%
0.01
19
44
37
140
2.94
7.48
1.5
1.4
—
—
—
0
0
51
229
2.55
7.43
1.7
1.5
—
—
—
0
0
59
284
2.42
7.41
1.3
1.2
—
—
—
0
0
83
467
2.18
7.21
1.8
1.4
2.43
2.16
g/l
1.03
59
290
92
540
2.14
7.16
13.2
6.8
—
—
—
0
0
18
43
4.44
7.14
1.2
1.5
—
—
—
0
0
139
954
2.07
7.09
5.0
2.7
178.31
88.45
ug/l
1.79
134
892
64
334
2.25
6.62
6.7
3.3
368.16
132.65
ng/l
0.91
52
237
117
769
2.01
6.57
2.2
1.8
96.93
100.19
pmol/l
0.31
59
371
60
307
2.27
6.49
1.7
1.6
—
—
—
0
0
16
27
6.27
6.42
1.7
1.6
—
—
—
0
0
66
357
2.17
6.21
1.9
1.9
—
—
—
0
0
54
269
2.30
6.20
3.8
2.0
143.78
97.18
ug/g
0.74
49
213
20
58
3.67
6.15
1.3
1.2
—
75.00
—
0
6
17
44
4.08
6.10
5.2
3.2
3.70
4.92
e9/l
1.71
17
44
44
203
2.43
6.00
10.3
5.1
105.61
103.68
mmol/l
2.11
44
203
148
1081
1.95
5.88
7.1
5.5
9.77
10.07
umol/l
0.15
143
1014
20
60
3.54
5.86
1.4
1.5
—
—
—
0
0
12
16
7.83
5.70
1.2
1.3
2.09
2.03
mmol/l
0.10
12
16
9
7
13.29
5.62
1.9
1.3
—
—
—
0
0
17
47
3.81
5.59
1.8
1.7
80.91
225.57
ug/l
1.79
17
42
20
63
3.37
5.45
4.3
2.8
0.20
0.23
g/l
—
10
19
96
621
1.90
5.39
3.2
2.2
—
—
—
0
0
59
325
2.08
5.22
1.6
1.7
1169.13
1264.75
nmol/l
0.42
50
247
10
12
8.63
5.11
1.7
1.4
—
—
—
0
0
32
142
2.44
4.72
2.9
2.3
3.54
7.89
e9/l
0.90
27
122
23
87
2.82
4.64
2.2
3.7
25.90
24.86
mmol/l
0.82
23
87
103
707
1.80
4.63
4.3
3.3
31.92
29.80
ng/l
0.07
77
427
7
5
14.35
4.60
1.1
1.6
—
—
—
0
0
36
172
2.28
4.51
6.0
4.5
—
—
—
0
0
39
193
2.22
4.50
9.9
5.5
-0.18
1.38
mmol/l
1.10
33
157
71
438
1.88
4.48
1.8
1.4
21.20
21.88
nmol/l
0.16
64
367
10
16
6.47
4.34
1.2
1.3
—
—
—
0
0
13
29
4.68
4.31
1.2
1.2
—
—
—
0
0
48
262
2.04
4.31
1.7
1.3
—
—
—
0
0
14
34
4.31
4.28
9.8
2.4
—
—
—
0
0
21
79
2.82
4.28
6.2
3.7
—
—
—
0
0
89
596
1.78
4.28
8.1
3.0
—
—
—
0
0
79
519
1.78
4.02
1.4
1.3
0.60
1.68
u/ml
0.86
17
165
35
175
2.17
3.93
1.2
1.2
—
—
—
0
0
8
11
7.48
3.89
1.5
1.6
—
—
—
0
0
83
558
1.74
3.88
7.7
3.7
0.00
0.00
estimate
-0.00
39
196
10
19
5.44
3.87
1.2
1.8
—
—
—
0
0
13
33
4.10
3.86
2.8
2.8
0.99
1.27
mmol/l
1.57
13
33
97
686
1.69
3.75
3.5
3.0
2.32
2.35
mmol/l
1.22
91
607
10
21
4.92
3.59
3.7
4.4
—
—
—
0
0
8
13
6.32
3.53
1.5
1.8
13.56
12.45
umol/l
—
8
13
22
94
2.47
3.53
2.5
1.7
—
—
—
0
0
64
410
1.76
3.49
1.4
1.3
11.80
8.70
u/ml
0.16
28
168
11
27
4.22
3.44
11.9
1.8
68.91
57.64
%
1.06
11
27
12
33
3.77
3.34
2.8
2.8
5.77
6.89
mmol/l
1.35
12
33
9
19
4.88
3.27
2.0
1.8
592.33
547.11
e6/l
—
9
19
68
451
1.71
3.26
7.0
3.6
1.01
1.02
kg/l
3.52
11
56
22
98
2.37
3.24
7.3
5.6
23.69
25.02
mmol/l
0.74
22
98
11
29
3.92
3.23
1.4
3.5
—
—
—
0
0
78
539
1.66
3.20
4.3
3.5
—
—
—
0
0
8
16
5.13
3.07
1.1
1.3
—
—
—
0
0
5
5
10.17
2.99
1.2
1.2
63.00
66.90
%
—
5
5
20
89
2.36
2.96
13.3
6.0
—
—
—
0
0
23
109
2.23
2.95
3.7
4.5
—
—
—
0
0
20
90
2.33
2.89
7.8
2.8
1.48
1.20
%
0.44
20
90
6
9
6.80
2.88
1.0
1.2
—
—
—
0
0
17
71
2.50
2.87
6.9
4.0
24.15
24.89
mmol/l
0.37
17
71
12
39
3.18
2.81
1.6
1.6
—
—
—
0
0
9
23
4.02
2.80
1.2
1.8
—
—
—
0
0
10
29
3.55
2.72
2.6
1.4
—
—
—
0
0
19
86
2.31
2.72
8.1
2.8
0.58
0.67
%
0.75
19
86
9
24
3.85
2.70
1.4
1.3
0.75
0.42
g/l
—
9
19
9
24
3.85
2.70
1.4
1.3
—
—
—
0
0
9
24
3.85
2.70
1.4
1.3
3.36
2.77
g/l
—
9
19
9
24
3.85
2.70
1.4
1.3
7.84
6.57
g/l
—
9
19
5
7
7.26
2.56
1.0
1.1
—
—
—
0
0
225
2081
2.16
2.49
36.6
12.1
17.18
20.55
mg/l
1.21
210
1597
61
422
1.60
2.43
1.4
1.3
28.52
27.35
iu/ml
0.04
19
150
10
34
3.02
2.31
2.5
2.0
—
—
—
0
0
32
189
1.80
2.28
1.3
1.4
—
—
—
0
0
27
152
1.87
2.23
6.3
3.2
—
—
—
0
0
5
9
5.64
2.22
1.0
1.1
—
—
—
0
0
15
69
2.25
2.09
1.1
1.4
353.78
322.28
ug/g
—
9
41
7
20
3.57
2.07
3.6
2.8
—
—
—
0
0
111
897
1.44
2.06
2.3
2.0
—
—
—
0
0
7
21
3.40
1.98
1.1
1.3
—
—
—
0
0
5
11
4.62
1.95
1.0
1.2
—
—
—
0
0
6
16
3.82
1.94
1.5
1.2
—
—
—
0
0
7
22
3.24
1.89
2.3
2.5
—
—
—
0
0
9
35
2.63
1.82
1.6
1.1
—
—
—
0
0
17
88
2.00
1.80
14.2
2.7
—
—
—
0
0
9
36
2.56
1.76
1.1
1.2
—
—
—
0
0
17
89
1.98
1.75
2.2
2.3
—
—
—
0
0
27
166
1.71
1.70
1.5
2.9
47.91
53.59
u/ml
0.10
27
160
19
105
1.88
1.68
13.7
6.1
0.60
0.67
%
0.32
19
105
5
14
3.62
1.62
5.2
2.8
—
—
—
0
0
5
14
3.62
1.62
3.4
1.9
12.04
11.16
%
—
5
14
23
137
1.75
1.62
4.7
2.3
—
—
—
0
0
198
1817
1.49
1.61
41.1
14.6
15.48
14.72
%
1.07
198
1794
10
43
2.38
1.61
10.4
3.8
—
—
—
0
0
35
235
1.57
1.58
1.6
1.3
—
—
—
0
0
5
15
3.38
1.53
1.0
1.1
—
—
—
0
0
9
37
2.49
1.49
4.4
2.5
—
—
—
0
0
6
22
2.77
1.44
2.7
3.0
—
—
—
0
0
6
22
2.77
1.44
2.7
3.0
105.83
106.32
mmol/l
—
6
22
6
22
2.77
1.44
2.7
3.0
3.97
3.85
mmol/l
—
6
22
66
825
0.73
1.42
2.9
2.8
—
—
—
0
0
18
107
1.74
1.30
14.1
6.0
1.47
1.50
%
0.02
18
107
12
64
1.92
1.20
1.4
1.1
—
—
—
0
0
10
50
2.04
1.18
1.9
2.3
—
—
—
0
0
28
194
1.50
1.13
1.5
1.5
—
—
—
0
0
190
2015
0.73
1.12
4.7
4.2
5.51
5.82
mmol/l
2.81
181
1866
182
1682
1.33
1.12
5.1
4.3
14.62
14.56
pmol/l
0.12
175
1554
30
213
1.47
1.08
1.7
3.9
20.45
10.12
ug/l
0.24
22
169
5
22
2.30
1.04
1.0
1.2
—
—
—
0
0
26
182
1.48
1.01
9.9
3.5
—
—
—
0
0
22
150
1.51
0.97
1.5
1.5
—
—
—
0
0
6
27
2.25
0.94
1.3
1.2
—
—
—
0
0
6
27
2.25
0.94
1.0
1.0
—
—
—
0
0
228
2203
1.60
0.92
36.8
13.8
78.52
71.09
umol/l
1.22
228
2203
6
29
2.10
0.90
1.3
1.2
—
—
—
0
0
8
42
1.94
0.89
1.0
1.1
—
—
—
0
0
8
42
1.94
0.89
1.0
1.1
—
—
—
0
0
6
32
1.90
0.82
2.5
2.8
—
—
—
0
0
17
242
0.68
0.77
1.8
1.4
—
—
—
0
0
68
579
1.24
0.76
1.7
1.6
1.42
1.44
mmol/l
0.09
59
493
5
24
2.11
0.75
1.2
1.0
—
—
—
0
0
219
2115
1.37
0.71
31.9
13.1
139.40
139.82
mmol/l
1.72
219
2057
5
26
1.94
0.71
1.0
3.2
—
—
—
0
0
228
2220
1.47
0.66
26.6
9.7
26.05
24.64
u/l
0.62
228
2145
219
2122
1.34
0.62
32.5
13.1
3.94
3.94
mmol/l
0.20
219
2061
0
20
0.00
0.60
0.0
1.1
—
0.46
—
0
11
156
1464
1.18
0.59
4.3
3.4
—
—
—
0
0
6
35
1.73
0.58
2.3
2.9
—
—
—
0
0
8
54
1.50
0.58
2.4
2.4
—
—
—
0
0
6
38
1.59
0.54
2.2
2.2
5.12
4.97
kpa
—
6
38
6
38
1.59
0.54
2.2
2.2
7.70
8.72
kpa
—
6
38
9
64
1.42
0.52
7.3
5.3
1.20
1.18
mmol/l
—
9
58
15
110
1.39
0.50
1.0
1.1
—
—
—
0
0
17
128
1.35
0.49
1.2
1.2
—
—
—
0
0
11
153
0.71
0.47
1.4
1.2
—
—
—
0
0
12
163
0.72
0.45
1.4
1.4
—
—
—
0
0
203
1967
1.20
0.44
5.9
5.1
2.04
2.44
mu/l
0.29
194
1825
20
248
0.79
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
11.2
—
0.71
—
0
15
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
214
2181
0.84
0.33
27.1
11.4
—
—
—
0
0
51
563
0.88
0.31
1.6
1.5
—
—
—
0
0
7
57
1.23
0.29
3.1
4.3
3.80
3.83
mmol/l
—
7
57
228
2307
0.80
0.27
49.3
18.2
30.17
30.21
pg
0.12
228
2277
30
263
1.16
0.27
1.3
1.2
—
—
—
0
0
22
188
1.19
0.26
1.4
1.6
—
—
—
0
0
228
2306
0.81
0.25
49.4
18.2
91.54
90.97
fl
0.96
228
2276
9
74
1.22
0.25
2.0
1.3
328.89
306.00
mu/l
—
9
68
228
2305
0.81
0.24
50.3
18.2
38.72
40.14
%
2.58
215
2184
202
1982
1.12
0.22
4.4
3.8
1.31
1.29
mmol/l
0.22
196
1830
210
2065
1.13
0.22
4.8
4.2
1.46
1.55
mmol/l
2.09
202
1919
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
29.20
—
0
10
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
276.57
—
0
7
0
14
0.00
0.20
0.0
15.0
—
933.14
—
0
14
5
70
0.71
0.17
51.8
6.5
—
—
—
0
0
178
1813
0.93
0.16
43.7
15.7
329.12
331.49
g/l
3.09
178
1806
20
178
1.13
0.15
1.4
1.2
126.57
147.83
iu/ml
—
6
79
210
2074
1.09
0.14
4.9
4.3
4.53
4.84
mmol/l
4.57
202
1934
25
228
1.11
0.14
1.7
1.8
—
—
—
0
0
6
72
0.83
0.07
1.3
1.4
—
—
—
0
0
6
72
0.83
0.07
4.7
5.1
—
—
—
0
0
6
72
0.83
0.07
1.3
1.4
—
—
—
0
0
6
72
0.83
0.07
1.3
1.4
—
—
—
0
0
6
73
0.82
0.07
1.3
1.3
—
—
—
0
0
7
83
0.84
0.07
1.7
1.7
—
—
—
0
0
11
102
1.08
0.03
1.4
1.1
—
—
—
0
0
211
2111
1.00
0.00
5.2
4.8
2.63
2.86
mmol/l
3.77
202
1963
25
246
1.02
0.00
3.2
4.5
0.89
2.09
ug/l
2.56
18
222
0
5
0.00
0.00
0.0
1.4
—
1.83
—
0
5
5
56
0.89
0.00
1.0
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.3
1.4
—
—
—
0
0
8
80
1.00
-0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
14.55
—
0
6
0
9
0.00
-0.00
0.0
1.9
—
144.44
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
115.63
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
120.33
—
0
8
0
8
0.00
-0.00
0.0
3.8
—
36562.50
—
0
8
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
57
0.87
-0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.20
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT 2.507 [2.07, 3.04] < 0.001
Birth year 0.993 [0.99, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 944 females with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Males

Parameter HR [95% CI] p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT 1.985 [1.37, 2.88] < 0.001
Birth year 0.991 [0.98, 1.0] 0.061

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 199 males with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT.

N-year risk Females Males
1 0.361% 0.465%
5 1.382% 2.756%
10 3.588% 6.675%
15 6.665% 12.351%
20 11.246% 20.503%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT – Drug-induced systemic lupus erythematosus

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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