Risteys · DRUGADVERS_SYSTEMIC_LUPUS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M32.0# 1 out of 7 registries used, show all original rules.	239
4. Check minimum number of events None	239
5. Include endpoints None	239
6. Filter based on genotype QC (FinnGen only)	239

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1257	1021	229
Only index persons	1098	918	180
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.01
Only index persons	0.03	0.03	0.01
Median age at first event (years)
Whole population	52.81	51.34	58.87
Only index persons	50.83	49.95	55.29

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	239	201	38
Unadjusted period prevalence (%)	0.06	0.07	0.02
Median age at first event (years)	46.86	46.11	50.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
226: Matched controls
2258

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M32.0

ICD-10 Finland

Drug-induced systemic lupus erythematosus

+∞

323.0

225

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

1482.2

213.1

175

P01BA02

ATC

hydroxychloroquine; oral

68.7

141.3

170

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

39.7

114.4

159

127

M32.8

ICD-10 Finland

Other forms of systemic lupus erythematosus

1320.2

92.7

M32.1

ICD-10 Finland

Systemic lupus erythematosus with organ or system involvement

+∞

88.5

L04AX01

ATC

azathioprine; systemic

30.9

67.3

M32

ICD-10 Finland

Systemic lupus erythematosus

553.8

47.1

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

17.7

46.8

H02AB06

ATC

prednisolone; systemic

8.7

44.7

182

730

H02AB07

ATC

prednisone; oral

9.6

44.3

107

194

7100A

ICD-9 Finland

Diffuse diseases of connective tissue, Systemic lupus erythematosus

508.1

43.8

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

56.4

42.1

L04AA06

ATC

mycophenolic acid; systemic

48.9

41.8

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

7.2

41.5

156

533

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

11.9

37.4

M05BA04

ATC

alendronic acid; oral

11.8

36.4

L93.0

ICD-10 Finland

Discoid lupus erythematosus

374.2

32.8

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

28.4

32.4

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

12.3

29.7

N08.5*M32.1

ICD-10 Finland

Glomerular disorders in systemic lupus erythematosus

+∞

28.8

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

8.7

27.2

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

8.2

26.8

106

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

14.9

25.9

73410

ICD-8 Finland

Diffuse diseases of connective tissue, Systemic lupus erythematosus

+∞

25.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.4

24.5

141

618

G05.8*M32.1

ICD-10 Finland

Encephalitis in systemic lupus erythematosus

+∞

22.2

C08CA05

ATC

nifedipine; systemic

9.7

21.0

M35.1

ICD-10 Finland

Other overlap syndromes

121.3

21.0

D68.8

ICD-10 Finland

Other specified coagulation defects

50.9

19.6

G73.7*M32.1

ICD-10 Finland

Myopathy in systemic lupus erythematosus

+∞

19.0

TPH04

NOMESCO Finland

Cathetrisation of vein

4.3

18.9

285

R50.9

ICD-10 Finland

Fever, unspecified

5.2

18.7

164

L88

ICPC

Rheumatoid/seropositive arthritis

11.9

17.9

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

9.6

17.8

B01AA03

ATC

warfarin; systemic

4.9

17.4

170

ZX120

NOMESCO Finland

Intravenous

5.8

16.7

105

M05BA07

ATC

risedronic acid; oral

15.2

16.5

A02BC02

ATC

pantoprazole; systemic

3.7

16.2

179

1149

L04AA01

ATC

[U] ciclosporin; systemic

19.0

16.0

H02AB04

ATC

methylprednisolone; systemic

4.2

15.6

206

N02AX02

ATC

tramadol; systemic, rectal

3.0

14.0

125

660

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.2

13.9

409

E000001

ATC

3.4

13.7

305

A02BC03

ATC

lansoprazole; oral

3.1

13.4

426

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.7

13.3

220

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.9

13.1

127

695

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.8

13.0

206

Z01.8

ICD-10 Finland

Other specified special examinations

3.3

12.8

312

D07AB08

ATC

desonide; topical

4.3

12.7

139

A49.9

ICD-10 Finland

Bacterial infection, unspecified

5.3

12.7

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.8

12.7

108

J01MA12

ATC

levofloxacin; systemic

3.7

12.5

205

C03CA01

ATC

furosemide; systemic

3.2

12.5

318

E0000UV

ATC

2.8

12.2

118

633

J05AB01

ATC

aciclovir; systemic

3.2

12.2

320

P01BA01

ATC

chloroquine; systemic

49.5

12.0

XX9XE

NOMESCO Finland

Other ultrasound examination

31.9

11.8

A07AA02

ATC

nystatin; oral

5.6

11.8

B01AB05

ATC

enoxaparin; parenteral

2.9

11.7

442

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.8

11.5

164

L04AD01

ATC

ciclosporin; systemic

13.7

11.4

N02AJ06

ATC

codeine and paracetamol; systemic

2.7

11.1

106

557

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.2

10.2

241

XF400

NOMESCO Finland

ECG with 12 standard connections

3.4

10.1

192

J05AB11

ATC

valaciclovir; oral

3.5

9.9

165

D69.3

ICD-10 Finland

Idiopathic thrombocytopenic purpura

57.5

9.7

J01FA06

ATC

roxithromycin; oral

2.5

9.7

120

713

J99.1*M32.1

ICD-10 Finland

Respiratory disorders in systemic: lupus erythematosus

+∞

9.4

AA1AD

NOMESCO Finland

CT of head and brain

2.9

9.4

289

A02BC01

ATC

omeprazole; systemic

2.6

9.3

396

M05BB03

ATC

alendronic acid and colecalciferol; oral

10.7

9.2

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

16.5

9.2

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

4.0

9.1

105

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.5

9.1

151

J01FF01

ATC

clindamycin; systemic

2.6

9.1

428

J01MA02

ATC

ciprofloxacin; systemic

2.4

8.9

548

M05BA01

ATC

etidronic acid; systemic

52.1

8.7

R06.0

ICD-10 Finland

Dyspnoea

2.7

8.6

319

KA3AT

NOMESCO Finland

Biopsy of kidney with ultrasound guidance

21.0

8.6

N08.5

ICD-10 Finland

Glomerular disorders in systemic connective tissue disorders

+∞

8.4

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

3.1

8.3

192

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

8.7

8.2

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

34.7

8.1

EBA10

NOMESCO Finland

Surgical removal of tooth

3.6

8.0

118

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

5.7

7.9

J01MA14

ATC

moxifloxacin; systemic

3.7

7.9

102

H26.3

ICD-10 Finland

Drug-induced cataract

46.6

7.8

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

2.9

7.7

201

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.2

7.5

117

743

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

4.1

7.5

SAA03

NOMESCO Finland

Extended examination of mouth

2.2

7.5

109

672

M05BX04

ATC

denosumab; parenteral

4.7

7.3

Z3231

NOMESCO Finland

Registered nurse

2.3

7.3

424

H04.10

ICD-10 Finland

Dry eye syndrome

3.3

7.3

121

B02.9

ICD-10 Finland

Zoster without complication

4.5

7.3

C02CA01

ATC

prazosin; oral

31.1

7.2

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

3.3

7.2

122

B01AB04

ATC

dalteparin; parenteral

5.3

7.2

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

5.3

7.2

R07.4

ICD-10 Finland

Chest pain, unspecified

2.4

7.1

342

Z50.1

ICD-10 Finland

Other physical therapy

4.5

7.1

N02BE01

ATC

paracetamol; systemic, rectal

3.0

7.0

205

1722

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.9

7.0

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

7.1

6.9

L04AA13

ATC

leflunomide; oral

8.7

6.9

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

3.5

6.9

102

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.2

6.9

126

L99

ICPC

Musculoskeletal disease other

7.6

6.8

M80.4

ICD-10 Finland

Drug-induced osteoporosis with pathological fracture

41.3

6.8

R4120

NOMESCO Finland

Occupational therapy

3.8

6.7

R59.1

ICD-10 Finland

Generalized enlarged lymph nodes

12.8

6.7

L27.0

ICD-10 Finland

Generalized skin eruption due to drugs and medicaments

10.5

6.6

ZXD05

NOMESCO Finland

Urgent procedure

2.2

6.6

433

A02BA02

ATC

ranitidine; systemic

2.5

6.6

257

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.7

6.5

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

4.1

6.5

D07AC01

ATC

betamethasone; topical

2.1

6.5

534

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.1

6.5

130

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

4.9

6.5

SPAT1148

SPAT

Treatment of chronic ulcer or burn

3.0

6.4

139

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.3

6.4

109

A01AC01

ATC

triamcinolone; local oral

11.5

6.4

D69.6

ICD-10 Finland

Thrombocytopenia, unspecified

11.5

6.4

318

Kela drug reimbursment

Teriparatide

18.7

6.3

SPAT1325

SPAT

Vaccination

2.2

6.3

465

N16.4*M32.1

ICD-10 Finland

Renal tubulo-interstitial disorders in systemic lupus erythematosus

+∞

6.3

N05.8

ICD-10 Finland

Unspecified nephritic syndrome, other

+∞

6.3

7108X

ICD-9 Finland

Diffuse diseases of connective tissue, Other specified diffuse diseases of connective tissue

+∞

6.3

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

6.1

6.3

N32.9

ICD-10 Finland

Bladder disorder, unspecified

27.5

6.3

1XC02

NOMESCO Finland

27.5

6.3

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

4.7

6.2

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

3.9

6.2

UGC12

NOMESCO Finland

Flexible bronchoscopy

4.1

6.2

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

4.4

6.2

C09AA02

ATC

enalapril; systemic

2.6

6.2

206

205

Kela drug reimbursment

Chronic hypertension

2.3

6.2

310

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.6

6.2

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

3.1

6.1

123

J02AC01

ATC

fluconazole; systemic

2.0

6.1

127

882

X59

ICD-10 Finland

Exposure to unspecified factor

2.5

6.1

245

A02BC05

ATC

esomeprazole; systemic

2.0

6.1

105

678

N03AX16

ATC

pregabalin; oral

2.2

6.0

351

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.1

6.0

453

S97

ICPC

Chronic ulcer skin

4.7

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT	2.507 [2.07, 3.04]	< 0.001
Birth year	0.993 [0.99, 1.0]	0.127

During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 944 females with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT	1.985 [1.37, 2.88]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.061

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 199 males with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT.

N-year risk	Females	Males
1	0.361%	0.465%
5	1.382%	2.756%
10	3.588%	6.675%
15	6.665%	12.351%
20	11.246%	20.503%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT – Drug-induced systemic lupus erythematosus

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M320
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Drug-induced systemic lupus erythematosus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints