peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
250 |
4. Check minimum number of eventsNone |
250 |
5. Include endpointsNone |
250 |
6. Filter based on genotype QC (FinnGen only) |
250 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates radicum nervorum cervicalium non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Cervical root disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1967 | 895 | 1060 |
| Only index persons | 1814 | 845 | 969 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 53.07 | 52.51 | 53.45 |
| Only index persons | 52.39 | 51.91 | 52.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 250 | 128 | 122 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 53.69 | 51.99 | 55.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 223
- Matched controls
- 2229
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.2
ICD-10 Finland
Cervical root disorders, not elsewhere classified
+∞
245.6
188
*
XA402
NOMESCO Finland
ENMG
78.2
81.7
90
19
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
24.4
47.7
69
40
3532A
ICD-9 Finland
Nerve root and plexus disorders, Cervical root lesions, not elsewhere classified
+∞
36.4
34
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
14.7
33.9
59
53
N03AX16
ATC
pregabalin; oral
6.4
32.3
106
276
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
6.9
30.1
88
193
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.6
25.9
41
28
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
21.5
25.9
38
21
G54.0
ICD-10 Finland
Brachial plexus disorders
73.0
23.4
26
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
14.5
22.3
38
31
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.2
21.7
40
39
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
+∞
20.1
19
*
M54.2
ICD-10 Finland
Cervicalgia
8.4
19.3
44
63
N02AX02
ATC
tramadol; systemic, rectal
3.7
19.3
131
614
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
19.0
18
*
G56.2
ICD-10 Finland
Lesion of ulnar nerve
72.7
18.0
20
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
15.0
17.0
28
21
M53.1
ICD-10 Finland
Cervicobrachial syndrome
5.6
17.0
53
117
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
97.4
16.8
18
*
N03AX12
ATC
gabapentin; oral
4.4
15.5
62
178
ACC51
NOMESCO Finland
Release of median nerve
85.8
14.8
16
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
13.7
13
*
N06AA09
ATC
amitriptyline; systemic
5.3
13.3
42
93
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.9
12.9
44
106
K29
ICPC
Cardiovascular sympt/complt other
9.1
11.6
24
29
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.6
10.9
54
183
M54.5
ICD-10 Finland
Low back pain
2.7
10.3
89
435
Z01.9
ICD-10 Finland
Special examination, unspecified
5.9
10.1
28
53
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
9.5
51
182
M03BX02
ATC
tizanidine; oral
2.5
9.4
154
1049
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
9.4
123
747
M54.4
ICD-10 Finland
Lumbago with sciatica
3.1
9.0
53
201
M50.3
ICD-10 Finland
Other cervical disc degeneration
9.2
9.0
18
21
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
6.9
8.7
21
33
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.3
8.7
32
83
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
8.7
95
521
L01
ICPC
Neck symptom/complaint
3.5
8.7
41
133
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
28.7
8.6
11
*
Z50.1
ICD-10 Finland
Other physical therapy
5.0
8.5
27
60
M54.1
ICD-10 Finland
Radiculopathy
7.0
8.4
20
31
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
+∞
8.4
8
*
G55.2
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
8.4
8
*
M01AH05
ATC
etoricoxib; oral
2.3
7.7
144
996
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
7.5
74
376
M79.6
ICD-10 Finland
Pain in limb
2.3
7.4
83
452
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.6
7.4
18
29
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.2
7.4
27
70
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
+∞
7.3
7
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
7.3
33
103
A29
ICPC
General symptom/complaint other
3.3
7.3
36
121
R51.80
ICD-10 Finland
Headache
3.1
7.3
41
151
M01AB05
ATC
diclofenac; systemic, rectal
2.2
7.2
157
1149
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
12.6
7.2
12
10
M48.0
ICD-10 Finland
Spinal stenosis
3.2
7.1
37
129
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.2
7.1
26
68
K30
ICD-10 Finland
Functional dyspepsia
3.6
7.0
31
95
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
6.8
6.8
16
25
M01AE02
ATC
naproxen; oral, rectal
2.1
6.7
129
882
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
12.8
6.6
11
9
M53.0
ICD-10 Finland
Cervicocranial syndrome
4.4
6.6
23
57
A02BC02
ATC
pantoprazole; systemic
2.1
6.6
153
1128
M03BC51
ATC
orphenadrine, combinations; systemic
2.3
6.6
73
393
M77.4
ICD-10 Finland
Metatarsalgia
5.8
6.4
17
31
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
11.5
6.4
11
10
G50.0
ICD-10 Finland
Trigeminal neuralgia
+∞
6.3
6
*
M01AX17
ATC
nimesulide; oral
2.3
6.2
63
325
M25.5
ICD-10 Finland
Pain in joint
2.2
6.1
70
381
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
6.0
44
190
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
765
1.84
5.21
1.9
1.9
91.5
94.5
pmol/l
0.32
59
389
110
770
1.77
4.56
2.8
3.4
25.6
36.2
ng/l
0.63
74
531
122
893
1.72
4.23
2.9
3.9
—
—
—
0
0
60
361
1.87
4.04
3.1
3.5
133.2
161.9
ng/l
0.09
51
288
56
330
1.90
4.01
1.3
1.2
34.8
32.8
iu/ml
0.05
26
105
178
1488
1.68
3.39
4.3
4.0
9.2
11.5
mm/h
2.49
172
1373
116
879
1.60
3.26
4.7
5.3
1.2
1.2
mmol/l
1.32
109
801
67
442
1.70
3.26
1.6
1.6
23.3
20.5
nmol/l
0.38
60
378
25
118
2.24
3.23
1.6
1.6
—
—
—
0
0
51
315
1.78
3.11
1.2
1.2
33.2
13.3
u/ml
0.34
17
124
144
1178
1.52
2.71
6.4
10.1
4.1
4.0
e9/l
0.04
133
1030
176
1517
1.54
2.49
3.6
3.7
14.9
14.8
pmol/l
0.08
162
1365
0
66
0.00
2.44
0.0
1.4
—
—
—
0
0
5
8
6.35
2.38
1.2
1.4
28.2
34.4
umol/l
—
5
8
119
954
1.47
2.36
6.2
6.4
1.2
1.2
mmol/l
0.87
108
813
22
113
2.04
2.34
1.3
1.3
—
—
—
0
0
7
20
3.57
2.07
1.1
1.1
—
—
—
0
0
7
20
3.57
2.07
1.1
1.1
—
—
—
0
0
8
26
3.14
2.03
1.9
1.8
—
—
—
0
0
35
221
1.68
1.98
1.7
1.9
—
—
—
0
0
7
21
3.40
1.98
1.1
1.1
—
—
—
0
0
7
21
3.40
1.98
1.1
1.1
—
—
—
0
0
7
21
3.40
1.98
1.1
1.1
—
—
—
0
0
57
411
1.50
1.86
1.1
1.2
0.5
1.5
u/ml
1.44
13
125
29
177
1.72
1.86
4.5
5.8
1.0
1.3
mmol/l
1.67
29
168
34
218
1.65
1.83
1.7
1.8
—
—
—
0
0
203
1850
1.52
1.81
4.5
4.4
1.8
2.6
mu/l
0.63
194
1678
7
24
2.97
1.73
1.1
1.1
—
—
—
0
0
176
1570
1.41
1.68
6.7
7.5
79.9
79.7
u/l
0.01
171
1471
42
585
0.66
1.66
1.9
1.7
1.4
1.4
mmol/l
0.18
37
491
74
582
1.39
1.51
2.8
2.9
1198.6
883.7
ng/l
0.34
67
499
43
310
1.47
1.41
1.6
1.9
—
—
—
0
0
216
2024
1.49
1.37
14.4
13.3
19.4
24.3
mg/l
1.26
186
1582
57
436
1.40
1.36
1.6
1.7
2.0
1.2
mg/l
0.59
45
346
11
54
2.08
1.35
1.1
1.3
—
—
—
0
0
5
18
2.81
1.29
1.2
1.2
—
—
—
0
0
9
45
2.04
1.24
1.2
1.2
—
1.1
—
0
5
112
969
1.28
1.14
3.1
3.2
0.0
0.0
estimate
0.00
13
173
230
2201
1.56
1.11
16.7
15.6
78.3
76.8
umol/l
0.23
230
2201
5
21
2.41
1.09
1.0
1.5
51.9
17.7
ug/l
—
5
21
15
90
1.71
1.06
1.1
1.0
—
—
—
0
0
9
47
1.95
1.03
1.2
1.2
—
—
—
0
0
111
969
1.26
1.03
4.1
4.4
0.0
0.0
estimate
0.00
14
171
213
2017
1.38
1.01
4.6
4.5
6.1
6.0
mmol/l
1.01
204
1871
16
245
0.63
0.99
6.0
6.4
—
—
—
0
0
9
50
1.83
0.97
1.1
1.2
—
—
—
0
0
217
2069
1.37
0.91
4.4
4.5
4.5
4.7
mmol/l
2.44
208
1928
6
30
2.02
0.87
1.0
1.1
—
—
—
0
0
197
1858
1.28
0.86
15.1
14.0
40.9
40.3
%
0.70
167
1389
28
208
1.39
0.82
4.9
7.0
1.1
1.2
mmol/l
0.08
21
175
110
980
1.22
0.80
3.1
3.3
0.0
0.0
estimate
0.80
14
166
62
729
0.80
0.77
2.9
3.0
—
—
—
0
0
54
449
1.26
0.74
1.9
1.9
1.9
3.1
mg/l
6.57
46
388
205
1954
1.27
0.74
5.3
5.6
40.5
39.7
mmol/mol
0.57
196
1824
209
1999
1.28
0.71
3.8
4.0
1.3
1.3
mmol/l
0.28
199
1845
40
323
1.28
0.69
3.1
2.8
2.2
2.3
e6/l
0.04
30
171
25
324
0.75
0.67
1.4
1.4
—
—
—
0
0
13
189
0.67
0.67
2.3
1.7
—
—
—
0
0
219
2111
1.30
0.66
5.0
4.9
2.7
2.8
mmol/l
0.97
211
1958
5
29
1.74
0.64
1.0
1.1
6.3
7.8
mmol/l
—
5
22
44
525
0.80
0.63
4.0
3.6
0.0
0.0
estimate
0.00
13
167
8
50
1.62
0.62
1.3
1.3
—
12.5
—
0
5
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
16
114
1.43
0.60
3.0
3.1
3.3
1.4
mmol/l
—
9
91
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
10
64
1.59
0.59
1.3
1.6
0.0
0.1
iu/ml
—
5
11
46
386
1.23
0.59
1.4
1.7
448.4
12579056.9
pmol/l
0.50
40
318
8
55
1.47
0.56
1.4
1.4
—
—
—
0
0
16
116
1.41
0.56
1.2
1.2
183.5
135.9
iu/ml
—
7
52
28
346
0.79
0.54
1.6
1.7
1185.3
1260.2
nmol/l
0.17
21
259
9
62
1.47
0.53
1.4
1.9
—
—
—
0
0
15
201
0.73
0.51
3.0
2.9
—
—
—
0
0
12
85
1.43
0.48
2.8
3.8
25.7
24.1
mmol/l
1.12
12
78
212
2055
1.21
0.46
4.2
4.4
1.4
1.5
mmol/l
1.10
204
1905
8
56
1.44
0.43
2.6
1.6
—
—
—
0
0
8
57
1.42
0.42
1.1
1.1
—
—
—
0
0
5
32
1.57
0.42
1.2
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
39.0
—
0
9
0
18
0.00
0.40
0.0
1.0
—
578.9
—
0
10
0
19
0.00
0.39
0.0
3.4
—
—
—
0
0
92
854
1.12
0.35
3.2
4.4
37.0
35.9
g/l
1.34
85
801
17
136
1.27
0.34
2.3
2.8
147.1
188.8
ng/l
0.26
17
124
128
1213
1.11
0.34
2.9
2.8
—
—
—
0
0
6
45
1.34
0.34
5.2
1.1
3.1
3.8
mmol/l
—
6
40
204
1986
1.15
0.33
13.3
12.3
80.9
80.9
ml/min/173m2
0.02
184
1639
71
653
1.12
0.32
2.7
3.6
2.4
2.4
mmol/l
0.27
63
580
51
460
1.14
0.31
2.0
2.3
—
—
—
0
0
7
53
1.33
0.31
1.4
1.3
—
—
—
0
0
31
269
1.17
0.31
1.3
1.5
—
—
—
0
0
20
166
1.22
0.31
1.9
2.8
3.8
7.4
ug/l
1.25
15
149
24
206
1.18
0.27
1.6
2.1
32.4
30.1
u/l
0.16
18
170
8
67
1.20
0.26
1.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
5
43
1.17
0.21
1.4
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
26
232
1.13
0.19
2.2
4.5
2.6
61.2
ug/l
0.95
21
179
6
52
1.16
0.19
5.2
1.2
572.3
459.1
mg/l
—
6
47
7
60
1.17
0.18
1.0
1.5
—
—
—
0
0
7
61
1.15
0.17
1.3
1.6
—
—
—
0
0
51
540
0.93
0.14
2.7
2.9
0.3
0.4
e6/l
0.47
39
394
42
445
0.93
0.12
2.2
2.8
0.7
0.8
ug/l
0.70
28
288
79
761
1.06
0.12
3.3
3.3
—
—
—
0
0
5
48
1.04
0.09
1.2
1.5
—
—
—
0
0
6
54
1.11
0.09
1.2
1.8
—
—
—
0
0
13
143
0.90
0.07
1.4
1.8
—
—
—
0
0
36
344
1.05
0.07
2.3
2.6
0.8
0.8
e6/l
0.03
25
191
16
173
0.92
0.07
5.6
2.7
55.4
66.0
ml/min/173m2
—
5
69
25
259
0.96
0.02
2.0
2.1
2.4
2.4
g/l
0.11
25
241
62
610
1.02
0.02
3.4
4.1
23.0
21.3
%
0.42
34
289
12
123
0.97
0.00
1.3
1.7
—
—
—
0
0
14
144
0.97
0.00
1.4
1.5
—
—
—
0
0
26
255
1.02
0.00
3.3
6.3
104.9
103.7
mmol/l
0.85
26
250
11
105
1.05
0.00
1.1
1.2
520.7
134.7
u/ml
0.41
11
95
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.8
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
122.7
—
0
6
5
51
0.98
0.00
1.0
1.8
39.1
38.2
g/l
—
5
43
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.0
1.9
0.0
1.7
g/l
—
5
50
5
56
0.89
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
1.2
2.4
1.2
1.4
%
—
9
98
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
0.00
0.0
2.6
—
126.9
—
0
7
0
7
0.00
0.00
0.0
1.0
—
112.0
—
0
7
0
9
0.00
0.00
0.0
2.1
—
73.2
—
0
9
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
7.9
—
0
8
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
0.00
1.5
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
7
72
0.97
0.00
1.7
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_CERVROOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.156 [0.87, 1.54] | 0.324 |
| Birth year | 0.996 [0.99, 1.0] | 0.362 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 666 females with G6_CERVROOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.369 [1.08, 1.73] | 0.009 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 773 males with G6_CERVROOT died.
Mortality risk
Mortality risk for people of age
years, who have G6_CERVROOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.23% |
| 5 | 0.607% | 1.299% |
| 10 | 1.623% | 3.363% |
| 15 | 3.355% | 6.757% |
| 20 | 5.694% | 11.257% |
Relationships between endpoints
↥Index endpoint: G6_CERVROOT – Cervical root disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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