peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
250 |
4. Check minimum number of eventsNone |
250 |
5. Include endpointsNone |
250 |
6. Filter based on genotype QC (FinnGen only) |
250 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates radicum nervorum cervicalium non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Cervical root disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1967 | 895 | 1060 |
| Only index persons | 1814 | 845 | 969 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 53.07 | 52.51 | 53.45 |
| Only index persons | 52.39 | 51.91 | 52.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 250 | 128 | 122 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 53.69 | 51.99 | 55.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 223
- Matched controls
- 2229
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.2
ICD-10 Finland
Cervical root disorders, not elsewhere classified
+∞
245.6
188
*
XA402
NOMESCO Finland
ENMG
78.2
81.7
90
19
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
24.4
47.7
69
40
3532A
ICD-9 Finland
Nerve root and plexus disorders, Cervical root lesions, not elsewhere classified
+∞
36.4
34
*
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
14.7
33.9
59
53
N03AX16
ATC
pregabalin; oral
6.4
32.3
106
276
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
6.9
30.1
88
193
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.6
25.9
41
28
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
21.5
25.9
38
21
G54.0
ICD-10 Finland
Brachial plexus disorders
73.0
23.4
26
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
14.5
22.3
38
31
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.2
21.7
40
39
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
+∞
20.1
19
*
M54.2
ICD-10 Finland
Cervicalgia
8.4
19.3
44
63
N02AX02
ATC
tramadol; systemic, rectal
3.7
19.3
131
614
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
19.0
18
*
G56.2
ICD-10 Finland
Lesion of ulnar nerve
72.7
18.0
20
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
15.0
17.0
28
21
M53.1
ICD-10 Finland
Cervicobrachial syndrome
5.6
17.0
53
117
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
97.4
16.8
18
*
N03AX12
ATC
gabapentin; oral
4.4
15.5
62
178
ACC51
NOMESCO Finland
Release of median nerve
85.8
14.8
16
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
13.7
13
*
N06AA09
ATC
amitriptyline; systemic
5.3
13.3
42
93
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.9
12.9
44
106
K29
ICPC
Cardiovascular sympt/complt other
9.1
11.6
24
29
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.6
10.9
54
183
M54.5
ICD-10 Finland
Low back pain
2.7
10.3
89
435
Z01.9
ICD-10 Finland
Special examination, unspecified
5.9
10.1
28
53
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.3
9.5
51
182
M03BX02
ATC
tizanidine; oral
2.5
9.4
154
1049
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
9.4
123
747
M54.4
ICD-10 Finland
Lumbago with sciatica
3.1
9.0
53
201
M50.3
ICD-10 Finland
Other cervical disc degeneration
9.2
9.0
18
21
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
6.9
8.7
21
33
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.3
8.7
32
83
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
8.7
95
521
L01
ICPC
Neck symptom/complaint
3.5
8.7
41
133
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
28.7
8.6
11
*
Z50.1
ICD-10 Finland
Other physical therapy
5.0
8.5
27
60
M54.1
ICD-10 Finland
Radiculopathy
7.0
8.4
20
31
G54.4
ICD-10 Finland
Lumbosacral root disorders, not elsewhere classified
+∞
8.4
8
*
G55.2
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
8.4
8
*
M01AH05
ATC
etoricoxib; oral
2.3
7.7
144
996
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
7.5
74
376
M79.6
ICD-10 Finland
Pain in limb
2.3
7.4
83
452
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
6.6
7.4
18
29
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.2
7.4
27
70
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
+∞
7.3
7
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
7.3
33
103
A29
ICPC
General symptom/complaint other
3.3
7.3
36
121
R51.80
ICD-10 Finland
Headache
3.1
7.3
41
151
M01AB05
ATC
diclofenac; systemic, rectal
2.2
7.2
157
1149
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
12.6
7.2
12
10
M48.0
ICD-10 Finland
Spinal stenosis
3.2
7.1
37
129
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.2
7.1
26
68
K30
ICD-10 Finland
Functional dyspepsia
3.6
7.0
31
95
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
6.8
6.8
16
25
M01AE02
ATC
naproxen; oral, rectal
2.1
6.7
129
882
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
12.8
6.6
11
9
M53.0
ICD-10 Finland
Cervicocranial syndrome
4.4
6.6
23
57
A02BC02
ATC
pantoprazole; systemic
2.1
6.6
153
1128
M03BC51
ATC
orphenadrine, combinations; systemic
2.3
6.6
73
393
M77.4
ICD-10 Finland
Metatarsalgia
5.8
6.4
17
31
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
11.5
6.4
11
10
G50.0
ICD-10 Finland
Trigeminal neuralgia
+∞
6.3
6
*
M01AX17
ATC
nimesulide; oral
2.3
6.2
63
325
M25.5
ICD-10 Finland
Pain in joint
2.2
6.1
70
381
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
6.0
44
190
Mortality – FinRegistry
↥Association
Association between endpoint G6_CERVROOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.156 [0.87, 1.54] | 0.324 |
| Birth year | 0.996 [0.99, 1.0] | 0.362 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 666 females with G6_CERVROOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.369 [1.08, 1.73] | 0.009 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 773 males with G6_CERVROOT died.
Mortality risk
Mortality risk for people of age
years, who have G6_CERVROOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.23% |
| 5 | 0.607% | 1.299% |
| 10 | 1.623% | 3.363% |
| 15 | 3.355% | 6.757% |
| 20 | 5.694% | 11.257% |
Relationships between endpoints
↥Index endpoint: G6_CERVROOT – Cervical root disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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