Rhinophyma

L12_RHINOPHYMA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L71.1 Hospital discharge: ICD-9 — 6953D Hospital discharge: ICD-8 — 69530 Cause of death: ICD-10 — L71.1 Cause of death: ICD-9 — 6953D Cause of death: ICD-8 — 69530 2 out of 7 registries used, show all original rules.	202
4. Check minimum number of events None	202
5. Include endpoints None	202
6. Filter based on genotype QC (FinnGen only)	202

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L71
Name in latin: Rhinophyma

NAME	L12_RHINOPHYMA
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L711
HD_ICD_9	6953D
HD_ICD_8	69530
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L711
COD_ICD_9	6953D
COD_ICD_8	69530
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rhinophyma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1418	326	1079
Only index persons	1182	258	924
Unadjusted period prevalence (%)
Whole population	0.03	0.01	0.03
Only index persons	0.03	0.01	0.04
Median age at first event (years)
Whole population	62.67	49.47	66.72
Only index persons	62.60	47.46	66.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	202	32	170
Unadjusted period prevalence (%)	0.06	0.01	0.07
Median age at first event (years)	64.36	47.43	67.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
179: Matched controls
1788

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L71.1

ICD-10 Finland

Rhinophyma

15961.6

220.0

164

D06BX01

ATC

metronidazole; topical

78.2

106.5

120

D10BA01

ATC

isotretinoin; oral

99.9

83.2

L71.9

ICD-10 Finland

Rosacea, unspecified

186.4

53.1

J01AA07

ATC

tetracycline; systemic

16.8

49.4

L71.8

ICD-10 Finland

Other rosacea

128.9

30.8

J01AA04

ATC

lymecycline; systemic

9.7

28.0

D10AX03

ATC

azelaic acid; topical

44.9

22.4

L71

ICD-10 Finland

Rosacea

59.0

18.4

69530

ICD-8 Finland

Erythematous condition, Rosacea

+∞

15.9

QAA25

NOMESCO Finland

Destruction of lesion of head or neck

9.6

12.8

D10AF01

ATC

clindamycin; topical

20.7

11.8

ZXC10

NOMESCO Finland

Use of laser

13.3

10.1

QAA40

NOMESCO Finland

Laser therapy or photocoagulation of skin of head or neck

105.3

9.5

DHB00

NOMESCO Finland

Excision of lesion of external nose

19.9

9.1

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

4.3

8.8

I10

ICD-10 Finland

Essential (primary) hypertension

2.8

8.7

136

947

L71.0

ICD-10 Finland

Perioral dermatitis

94.2

8.5

ZXC12

NOMESCO Finland

Pulse colorlaser

83.3

7.5

DLW99

NOMESCO Finland

Other plastic operations on nose

41.6

6.8

E000001

ATC

2.8

6.5

185

E0000UV

ATC

2.4

6.5

405

205

Kela drug reimbursment

Chronic hypertension

2.3

6.4

440

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

6.07

6.17

1.0

1.5

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

6.14

5.68

1.1

1.5

—

nmol/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

138

1077

1.89

4.22

3.4

3.3

15.2

15.0

pmol/l

0.32

130

933

(3012544) pH of Venous blood

182

2.19

4.00

3.6

3.9

—

(3000991) Gas panel - Venous blood

156

2.25

3.88

5.1

8.8

—

(3009261) Glucose [Presence] in Urine by Test strip

106

787

1.73

3.60

5.1

3.9

0.0

estimate

0.00

136

(3021447) Carbon dioxide [Partial pressure] in Venous blood

176

2.12

3.56

3.7

3.9

5.9

5.6

kpa

0.57

168

(3035350) Ketones [Presence] in Urine by Test strip

104

775

1.70

3.43

5.0

3.9

0.0

estimate

0.00

147

(3009508) Creatinine [Moles/volume] in Urine

569

1.71

3.29

3.7

3.2

7.6

8.2

mmol/l

0.60

457

(3021601) Nitrite [Presence] in Urine by Test strip

103

772

1.68

3.28

6.2

5.3

0.0

estimate

0.00

145

(3012516) Albumin [Mass/volume] in Urine

559

1.68

3.08

3.5

3.3

97.5

180.8

mg/l

0.32

380

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

153

1292

1.76

2.97

8.3

8.4

82.8

80.2

u/l

0.28

144

1217

(3002256) Pathology report gross observation

196

1.95

2.96

1.7

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

601

1.65

2.94

4.4

4.0

18.2

11.7

mg/mmol

0.42

404

(3024561) Albumin [Mass/volume] in Serum or Plasma

744

1.62

2.84

4.7

5.4

34.1

34.5

g/l

0.33

700

(3029937) Albumin [Presence] in Urine by Test strip

441

1.66

2.71

6.3

4.1

0.0

estimate

0.00

139

(3011397) Hemoglobin [Presence] in Urine by Test strip

356

1.71

2.69

5.5

3.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

176

1577

1.90

2.45

19.2

17.6

26.3

27.8

mg/l

0.21

151

1280

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

678

1.56

2.45

4.8

3.3

—

(36304419) Bacteria [Presence] in Urine

488

1.59

2.41

4.0

3.1

—

(3018095) Leukocytes [#/volume] in Urine

625

1.56

2.39

5.0

3.7

37.7

87.7

e6/l

0.89

472

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

325

1.67

2.37

3.5

2.8

1.9

1.0

e6/l

0.59

204

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

581

1.56

2.35

2.5

2.1

70.4

75.4

nmol/l

0.74

502

(3009542) Hematocrit [Volume Fraction] of Blood

155

1352

1.63

2.24

17.5

18.3

39.8

39.3

0.18

870

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

761

1.50

2.12

3.7

4.3

—

(40761535) Cells panel - Urine sediment

141

1.88

2.08

5.4

3.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

104

843

1.48

2.03

7.1

7.3

1.2

mmol/l

0.13

711

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.89

2.02

1.2

1.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

120

1.94

2.02

1.6

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

515

1.52

2.01

4.1

3.1

0.5

e6/l

0.05

392

(3026493) Urate [Moles/volume] in Serum or Plasma

481

1.52

1.96

3.2

2.9

16430.6

9528.5

umol/l

0.25

406

(3037467) Urinalysis macro (dipstick) panel - Urine

130

1107

1.49

1.95

4.8

4.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

111

917

1.47

1.93

5.4

7.1

13.1

12.4

umol/l

0.27

105

871

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

611

1.48

1.92

3.4

1605.0

1726.2

ng/l

0.11

512

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

173

1572

1.70

1.90

6.3

4.8

4.3

4.4

mmol/l

0.80

166

1434

(3013826) Glucose [Moles/volume] in Serum or Plasma

122

1032

1.46

1.85

5.5

6.8

6.9

mmol/l

0.60

117

985

(3018677) aPTT in Platelet poor plasma by Coagulation assay

311

1.58

1.83

1.8

1.9

32.0

29.4

0.76

299

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

3.11

1.81

1.3

2.5

30.1

33.7

—

(3018418) pH of Serum or Plasma

480

1.49

1.80

6.3

4.7

7.4

1.74

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

156

1392

1.53

1.75

4.5

4.1

2.0

mu/l

0.13

149

1224

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

127

1.82

1.72

2.0

3.0

38.2

62.0

ml/min/173m2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

3.91

1.72

1.8

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

622

1.44

1.72

5.8

4.2

—

(3003338) MCHC [Mass/volume]

142

1246

1.47

1.71

24.8

22.4

332.5

333.3

g/l

0.49

142

1240

(3002582) Erythrocytes [#/volume] in Urine

567

1.45

1.71

4.3

3.2

15.9

168.1

e6/l

0.77

447

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

786

1.42

1.68

8.4

6.7

1.2

mmol/l

0.12

705

(3023520) Reticulocytes [#/volume] in Blood

184

1.67

1.66

1.7

2.6

75.6

67.1

e9/l

0.59

149

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

171

1564

1.61

1.64

5.4

4.8

1.3

1.4

mmol/l

0.86

157

1411

(40761511) CBC panel - Blood by Automated count

177

1633

1.68

1.63

18.5

16.8

—

(42870588) Differential panel, method unspecified - Blood

562

1.44

1.63

4.3

5.9

—

(3010144) Erythrocytes [#/volume] in Synovial fluid

3.63

1.62

1.8

1.2

15494.0

16086.4

e6/l

—

(3011648) Oxygen content in Venous blood

3.63

1.62

1.0

2.5

10.3

11.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

526

1.44

1.61

2.5

3.6

2.3

mmol/l

0.12

451

(3000850) Epithelial cells [#/volume] in Urine

384

1.48

1.56

3.3

2.6

5.0

3.8

e6/l

0.26

335

(40768804) Tissue Pathology biopsy report

622

1.41

1.56

2.7

2.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.91

1.51

1.5

1.8

—

(3044889) 12 lead EKG panel

135

1187

1.41

1.50

4.3

4.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

308

1.50

1.49

3.8

3.0

1.6

1.3

e6/l

0.16

188

(3003396) Base excess in Arterial blood by calculation

240

1.55

1.48

5.3

7.5

1.4

1.1

mmol/l

0.16

188

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

703

1.39

1.47

2.3

2.1

84.2

91.2

pmol/l

0.89

399

(3024928) Oxygen saturation in Venous blood

2.37

1.45

2.2

3.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

135

1.71

1.43

2.5

2.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

373

1.45

1.42

1.7

1276.7

1182.2

nmol/l

0.30

294

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

174

1612

1.57

1.41

5.9

5.4

2.5

2.6

mmol/l

0.58

163

1456

(3019150) Specific gravity of Urine by Refractometry

357

1.45

1.39

6.3

4.1

1.0

kg/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

170

1574

1.51

1.31

5.3

5.1

6.3

6.2

mmol/l

0.79

158

1417

(3023368) Bacteria identified in Blood by Culture

572

1.37

1.30

3.3

4.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

139

1.65

1.29

2.6

2.5

28.4

37.0

u/l

0.81

118

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

166

1531

1.47

1.29

5.7

4.3

1.4

1.3

mmol/l

1.14

158

1374

(40760888) Immunoglobulin light chains.free panel - Serum

2.09

1.28

2.9

3.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

174

1.57

1.23

5.3

6.9

1.4

1.5

mmol/l

0.01

165

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.21

1.23

1.1

1.5

—

(40758558) Short blood count panel - Blood

384

1.40

1.21

6.1

6.7

—

(3021589) Normoblasts [#/volume] in Blood

711

1.34

1.21

11.6

10.5

0.0

e9/l

0.53

585

(3013650) Neutrophils [#/volume] in Blood by Automated count

107

926

1.33

1.20

7.9

9.7

4.6

4.3

e9/l

0.59

815

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

165

1529

1.43

1.16

7.0

6.7

40.9

41.4

mmol/mol

0.26

154

1406

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

764

1.32

1.14

2.0

2.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

186

1.52

1.13

6.9

6.8

11.3

10.7

mmol/l

0.12

176

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

212

1.49

1.12

1.8

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

221

1.48

1.11

7.6

8.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

213

1.48

1.10

1.8

2.0

—

(3016502) Oxygen saturation in Arterial blood

222

1.47

1.09

5.6

7.7

94.7

95.1

0.15

214

(3013707) Erythrocyte sedimentation rate by Westergren method

132

1187

1.32

1.09

5.1

4.3

13.8

13.6

mm/h

0.04

121

1095

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

115

1019

1.30

1.04

3.6

3.5

59.5

57.5

u/l

0.08

107

942

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

162

1507

1.38

1.02

19.6

16.0

71.8

75.5

ml/min/173m2

1.30

138

1268

(3017143) Hepatitis C virus Ab [Presence] in Serum

149

1.53

1.00

2.2

1.5

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.88

1.00

1.9

1.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

2.20

0.98

1.2

1.9

—

(3026008) Bacteria identified in Urine by Culture

463

1.32

0.97

3.1

3.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

101

1.63

0.97

4.2

2.8

1.3

0.08

101

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

151

1.51

0.95

1.6

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.76

0.93

2.9

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.76

0.93

2.9

3.1

—

(3025941) Bacteria identified in Stool by Culture

1.67

0.93

1.2

1.3

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

2.18

0.92

2.2

1.5

1139.3

4483.3

e6/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.18

0.92

1.0

1.5

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

2.18

0.92

1.8

1.3

1.2

6.0

e6/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

523

1.30

0.91

3.0

3.7

33.0

34.7

u/l

0.19

498

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

311

1.36

0.90

1.6

2.1

—

(1616796) Gas panel - Central venous blood

1.94

0.89

4.6

3.5

—

(3034770) Mitochondria Ab [Titer] in Serum

1.94

0.89

1.0

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

629

1.28

0.89

2.9

2.5

147.6

168.9

ug/l

0.54

572

(3013512) EKG study

572

1.28

0.89

4.8

4.5

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

563

1.28

0.88

3.1

2.7

52.1

55.3

u/l

0.43

530

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.03

0.87

1.5

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

103

915

1.26

0.85

4.8

4.4

22.6

21.3

0.47

464

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

155

1.47

0.85

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.60

0.80

2.1

1.5

—

(3022621) pH of Urine by Test strip

115

1.52

0.80

3.2

2.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.84

0.79

1.0

2.2

64.3

63.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

320

1.31

0.76

6.4

5.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

340

1.30

0.73

1.6

1.7

1.3

1.6

mg/l

0.16

272

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.62

0.73

1.8

3.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.02

0.73

3.8

2.4

3.7

4.7

e9/l

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

1.78

0.72

4.4

2.8

0.9

nmol/l

—

(3006315) Basophils [#/volume] in Blood

810

1.22

0.71

6.7

5.7

0.0

e9/l

0.78

704

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

455

1.25

0.69

2.1

2.9

3.0

mg/l

0.13

395

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

1.87

0.69

3.8

3.1

55.8

59.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

1.87

0.69

1.0

1.7

—

7.7

—

(3000494) Fungus identified in Specimen by Culture

201

0.67

0.68

1.6

1.5

—

(3001604) Monocytes [#/volume] in Blood

805

1.21

0.66

6.7

5.7

0.6

e9/l

0.21

697

(4094501)

1.61

0.66

1.3

1.1

—

(40761536) Microorganisms panel - Urine sediment

138

1.42

0.65

5.6

3.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

440

1.24

0.64

4.2

3.8

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.74

0.64

1.6

1.7

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

1.74

0.64

1.0

1.8

—

(3020891) Body temperature

1.55

0.64

9.8

5.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.58

0.63

1.3

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

546

1.22

0.62

2.3

2.5

—

(3019060) Gas panel - Arterial blood

148

1.39

0.62

5.1

5.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.59

0.0

3.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

212

1.32

0.59

1.3

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

763

1.20

0.58

5.4

4.3

611.9

49.4

ng/l

0.47

592

(3019198) Lymphocytes [#/volume] in Blood

822

1.19

0.58

6.8

5.8

2.8

1.8

e9/l

0.44

732

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

343

1.25

0.56

4.1

4.2

69.0

406.2

ng/l

1.69

297

(3002030) Lymphocytes/100 leukocytes in Blood

777

1.19

0.54

6.7

6.2

24.9

25.5

0.17

717

(1761868) Lipid panel - Serum or Plasma

516

1.20

0.53

3.5

3.1

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

122

1137

1.18

0.53

5.7

5.1

3.2

2.7

ug/l

0.39

107

1006

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.51

0.52

1.5

1.2

—

(3013115) Eosinophils [#/volume] in Blood

829

1.18

0.52

6.8

5.9

0.2

e9/l

0.00

733

(40768443) Skin Pathology biopsy report

1.40

0.51

1.2

—

(40768797) Stomach Pathology biopsy report

200

1.29

0.49

1.5

1.4

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.59

0.46

2.0

3.9

14.6

2600.3

u/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

184

1.28

0.46

2.2

1.6

—

(3026782) Osmolality of Urine

371

1.20

0.45

3.6

3.1

616.8

595.0

mosm/kgh2o

0.27

314

(3014051) Protein [Presence] in Urine by Test strip

1.63

0.43

2.2

1.9

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.63

0.43

1.6

1.7

—

(3023419) Bacteria identified in Sputum by Culture

1.63

0.43

1.2

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

411

1.19

0.43

2.2

2.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.41

0.0

3.0

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

187

1.26

0.41

1.7

2.2

11.3

13.2

nmol/l

0.43

166

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.2

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

1.48

0.40

1.0

—

(3018010) Neutrophils/100 leukocytes in Blood

763

1.15

0.40

6.4

5.9

59.6

58.8

0.27

712

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.40

0.0

1.6

—

26226.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.40

0.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

278

0.81

0.39

1.8

1.9

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.39

0.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.38

0.39

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

156

0.75

0.36

1.4

1.2

—

(3021440) Promyelocytes/100 leukocytes in Blood

136

1.27

0.35

5.9

4.6

0.0

0.1

—

(3025159) Blasts/100 leukocytes in Blood

127

1.28

0.34

5.3

4.7

0.0

0.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.34

0.34

2.2

1.7

—

(3017181) Myelocytes/100 leukocytes in Blood

148

1.24

0.30

5.7

4.4

0.5

0.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.24

0.29

2.6

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.33

0.28

1.4

2.4

0.6

0.3

u/ml

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

206

1.19

0.28

1.3

1.1

17.8

u/ml

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

663

1.11

0.26

3.3

3.1

1.0

0.8

ug/l

0.59

457

(3005322) IgE [Units/volume] in Serum or Plasma

1.19

0.25

1.1

1.2

75.6

165.7

u/ml

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

243

0.85

0.25

3.9

4.9

34.1

30.6

0.63

158

(3032080) INR in Blood by Coagulation assay

793

1.10

0.24

14.4

10.6

1.4

1.3

inr

0.41

224

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

392

1.12

0.23

1.6

1.8

378.1

419.5

pmol/l

0.60

329

(3049717) Cytology report of Urine Cyto stain

1.25

0.23

2.9

2.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.28

0.22

4.0

6.0

0.7

0.9

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.26

0.22

1.4

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.26

0.22

1.4

1.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

442

1.11

0.22

1.7

1.6

15.3

19.7

nmol/l

2.33

367

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

220

1.16

0.22

1.4

1.2

21.1

45.3

iu/ml

—

(3000492) Spirometry study

135

1.20

0.22

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.22

0.22

1.4

1.2

—

(3003694) ABO and Rh group [Type] in Blood

404

1.11

0.21

1.4

1.3

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.21

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.21

0.0

2.9

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

3.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

3.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(4027681)

0.00

0.21

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3017704) Immunofixation for Urine

0.00

0.21

0.0

1.5

—

(4010399)

127

1.20

0.20

1.3

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

109

1.21

0.19

1.5

1.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.14

0.19

1.3

1.8

—

(3045414) Leukocytes [Presence] in Urine

1.17

0.18

2.1

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.22

0.18

2.2

2.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.15

0.17

1.3

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.12

0.17

3.0

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.74

0.15

1.3

1.4

—

37.9

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.13

0.15

4.2

5.9

1.4

1.7

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

112

1.17

0.15

4.0

3.1

0.1

0.2

e6/l

0.17

112

(1002224) Polysomnography panel

1.11

0.10

1.0

—

(3021901) Oxygen saturation in Capillary blood

1.09

0.09

4.8

2.7

—

(3037756) Immunofixation for Serum or Plasma

1.09

0.09

1.4

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

204

1.09

0.09

3.4

3.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.09

0.09

1.8

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.09

0.09

1.8

1.5

—

(4034850)

0.79

0.08

25.2

14.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.76

0.08

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

137

1.10

0.07

1.3

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.85

0.07

1.6

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

283

0.95

0.05

1.4

1.2

0.9

1.8

u/ml

—

(3022313) Gas panel - Capillary blood

110

0.90

0.05

3.2

3.6

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

140

1.08

0.04

2.9

3.6

0.3

1.7

mmol/l

—

107

(4035726)

148

0.94

0.02

1.4

1.5

—

(3019225) pH of Specimen

182

1.05

0.02

4.5

4.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

288

0.97

0.02

1.4

1.3

3.0

2.7

g/l

0.32

173

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

111

0.99

0.00

7.5

9.5

—

(3022145) Colonoscopy Study observation

185

0.97

0.00

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.94

0.00

1.7

1.9

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(44806420)

0.00

0.0

2.4

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

8.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3020073) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Specimen

0.00

0.0

1.6

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.00

0.00

2.2

1.6

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.4

—

13.7

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

9.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.1

—

(4015189)

0.00

0.0

1.8

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.88

0.00

1.7

2.2

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.3

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.5

—

(3020951) Lymphocytes/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

8.2

—

(3042847) Granulocytes/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.0

1.2

—

5.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

1.3

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.3

—

(21494814) CD8 cells/100 lymphocytes in Specimen

0.00

0.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

0.91

0.00

1.8

1.5

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(3034037) Hematocrit [Volume Fraction] of Mixed venous blood

0.00

0.0

8.6

—

(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.1

—

951.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.96

0.00

2.6

3.4

—

(3024471) HLA-A [Type]

0.00

0.0

1.0

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(36660697) Celiac disease serology panel - Serum

0.91

0.00

1.1

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

2.4

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.3

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3024932) HLA-DR beta [Type]

0.00

0.0

1.1

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

0.00

0.0

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3023365) Varicella zoster virus Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3000330) Specific gravity of Urine by Test strip

0.93

0.00

2.8

4.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(3018851) Theophylline [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

41.0

—

(4133840)

0.00

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

2.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_RHINOPHYMA and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
L12_RHINOPHYMA	1.076 [0.9, 1.29]	0.435
Birth year	0.991 [0.98, 1.0]	0.056

During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 774 males with L12_RHINOPHYMA died.

Mortality risk

Mortality risk for people of age

years, who have L12_RHINOPHYMA.

N-year risk	Females	Males
1	No data	0.243%
5	No data	1.406%
10	No data	3.532%
15	No data	6.807%
20	No data	11.741%

Relationships between endpoints

↥

Index endpoint: L12_RHINOPHYMA – Rhinophyma

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rhinophyma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints