No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
215 |
4. Check minimum number of eventsNone |
215 |
5. Include endpointsNone |
215 |
6. Filter based on genotype QC (FinnGen only) |
212 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L71
- Name in latin
- Rhinophyma
Similar endpoints
↥List of similar endpoints to
Rhinophyma
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1418 | 326 | 1079 |
| Only index persons | 1182 | 258 | 924 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.01 | 0.03 |
| Only index persons | 0.03 | 0.01 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 62.67 | 49.47 | 66.72 |
| Only index persons | 62.60 | 47.46 | 66.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212 | 34 | 178 |
| Unadjusted period prevalence (%) | 0.07 | 0.01 | 0.08 |
| Median age at first event (years) | 64.54 | 47.43 | 67.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 215
- Matched controls
- 2150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L71.1
ICD-10 Finland
Rhinophyma
16384.0
269.0
199
*
D10BA01
ATC
isotretinoin; oral
139.7
213.3
110
16
D06BX01
ATC
metronidazole; topical
42.6
179.6
141
92
L71.9
ICD-10 Finland
Rosacea, unspecified
96.9
126.3
67
10
J01AA07
ATC
tetracycline; systemic
15.3
87.3
101
118
J01AA04
ATC
lymecycline; systemic
8.3
46.1
78
138
L71.8
ICD-10 Finland
Other rosacea
183.2
43.6
44
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
12.3
27.5
29
27
D10AX03
ATC
azelaic acid; topical
22.7
23.0
33
17
L71
ICD-10 Finland
Rosacea
28.8
22.5
30
12
69530
ICD-8 Finland
Erythematous condition, Rosacea
+∞
18.0
17
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.8
12.4
43
132
E0000UV, ,
ATC
2.8
12.2
100
510
D10AF01
ATC
clindamycin; topical
11.0
11.3
21
21
E000001, ,
ATC
3.2
11.2
54
205
DLW99
NOMESCO Finland
Other plastic operations on nose
+∞
10.5
10
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
+∞
10.5
10
*
L71.0
ICD-10 Finland
Perioral dermatitis
104.4
9.5
10
*
ZXC12
NOMESCO Finland
Pulse colorlaser
+∞
9.4
9
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
9.2
38
130
R60.0
ICD-10 Finland
Localized oedema
3.2
8.6
39
141
205
Kela drug reimbursment
Chronic hypertension
2.4
8.4
89
494
DHB00
NOMESCO Finland
Excision of lesion of external nose
15.3
8.3
13
9
ZXC10
NOMESCO Finland
Use of laser
8.7
8.3
17
21
M10.9
ICD-10 Finland
Gout, unspecified
3.3
8.0
32
107
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
8.5
7.7
16
20
S04
ICPC
Lump/swelling localized
3.3
7.4
30
101
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
7.4
164
1219
J01DB01
ATC
cefalexin; oral
2.9
7.4
183
1433
L72.1
ICD-10 Finland
Trichilemmal cyst
4.8
7.3
17
38
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.0
6.8
33
124
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
1155
1.94
4.78
3.6
3.3
15.14
14.99
pmol/l
0.29
139
999
115
835
1.81
4.39
5.1
3.8
0.00
0.00
estimate
-0.00
25
141
113
829
1.77
4.06
5.1
3.8
0.00
0.01
estimate
0.50
27
170
112
821
1.76
4.03
6.0
5.2
0.00
0.00
estimate
-0.00
27
150
72
465
1.82
3.97
6.1
4.0
0.00
0.00
estimate
-0.00
22
144
107
789
1.71
3.65
4.6
5.4
34.23
34.56
g/l
0.25
100
743
90
642
1.69
3.42
4.4
3.8
16.97
11.66
mg/mmol
0.35
68
432
34
183
2.02
3.19
3.7
3.8
5.86
5.64
kpa
0.58
34
174
73
503
1.68
3.10
3.2
2.8
14100.77
9077.95
umol/l
0.20
62
427
162
1371
1.74
3.04
8.7
8.4
82.53
80.26
u/l
0.26
154
1294
95
709
1.61
2.91
4.6
3.2
—
—
—
0
0
188
1679
1.95
2.74
19.5
17.2
25.67
27.91
mg/l
0.35
164
1361
113
889
1.57
2.71
6.7
7.4
1.20
1.20
mmol/l
0.14
93
757
11
35
3.26
2.68
1.4
1.9
—
—
—
0
0
83
613
1.58
2.59
2.6
2.1
70.14
75.54
nmol/l
0.88
69
532
133
1094
1.57
2.57
5.5
5.4
6.80
6.93
mmol/l
0.39
128
1045
13
51
2.65
2.49
1.2
1.2
55.60
104.09
iu/ml
—
5
12
186
1678
1.80
2.30
6.3
4.8
4.24
4.39
mmol/l
1.27
178
1532
200
1848
2.18
2.29
28.7
24.8
40.26
40.14
%
0.09
183
1715
119
973
1.50
2.24
5.4
7.2
12.79
12.54
umol/l
0.10
114
929
73
539
1.54
2.23
4.0
3.1
0.52
0.49
e6/l
0.06
57
414
50
339
1.62
2.20
3.5
2.8
1.85
1.00
e6/l
0.62
30
212
86
661
1.50
2.17
5.8
4.0
—
—
—
0
0
84
643
1.50
2.16
3.3
3.3
1528.70
1676.62
ng/l
0.14
76
541
24
134
1.89
2.05
2.0
3.0
52.14
62.78
ml/min/173m2
—
7
60
101
809
1.47
2.05
2.2
2.7
—
—
—
0
0
167
1488
1.55
1.91
4.7
4.1
2.02
2.00
mu/l
0.07
159
1312
102
828
1.44
1.88
8.1
6.7
1.20
1.20
mmol/l
0.16
93
751
183
1669
1.65
1.85
5.4
4.8
1.30
1.36
mmol/l
1.23
168
1506
22
124
1.86
1.84
1.6
1.5
—
—
—
0
0
5
12
4.24
1.83
1.4
1.1
—
—
—
0
0
73
559
1.46
1.82
2.5
3.7
2.33
2.33
mmol/l
0.00
66
487
93
750
1.42
1.75
2.2
2.0
85.54
90.56
pmol/l
0.57
62
430
187
1721
1.66
1.74
5.9
5.3
2.49
2.58
mmol/l
0.82
175
1553
8
30
2.73
1.74
4.1
3.1
53.00
60.20
%
—
8
30
183
1679
1.60
1.68
5.4
5.0
6.29
6.16
mmol/l
0.75
170
1514
5
14
3.63
1.62
1.6
1.1
—
—
—
0
0
46
328
1.51
1.62
1.7
1.9
31.93
29.42
s
0.76
46
315
71
556
1.41
1.54
2.9
3.8
33.08
34.34
u/l
0.16
60
530
5
15
3.39
1.53
1.8
1.2
15494.00
16086.44
e6/l
—
5
9
178
1633
1.52
1.53
5.7
4.2
1.41
1.27
mmol/l
1.59
169
1467
59
448
1.44
1.51
2.0
1.7
1.42
1.33
mmol/l
0.50
54
364
143
1264
1.39
1.47
5.7
4.2
13.36
13.59
mm/h
0.06
132
1162
37
257
1.53
1.47
5.2
7.8
1.61
1.15
mmol/l
0.26
29
206
177
1627
1.50
1.45
7.1
6.6
41.10
41.33
mmol/mol
0.12
165
1496
52
393
1.43
1.36
1.7
1.7
1276.71
1176.44
nmol/l
0.32
38
310
44
323
1.46
1.34
3.7
3.0
1.53
1.21
e6/l
0.19
24
197
97
815
1.35
1.34
2.1
2.5
—
—
—
0
0
6
24
2.54
1.31
1.5
1.7
—
—
—
0
0
61
479
1.38
1.29
2.2
2.0
2.92
3.01
mg/l
0.12
52
414
114
987
1.33
1.26
8.3
9.8
4.54
4.28
e9/l
0.59
99
869
28
190
1.54
1.24
6.6
7.0
10.91
10.88
mmol/l
0.01
28
179
81
669
1.34
1.23
2.8
2.5
142.47
169.41
ug/l
0.81
74
607
174
1610
1.42
1.22
19.9
15.7
72.65
75.96
ml/min/173m2
1.20
150
1346
8
38
2.15
1.19
1.1
1.4
—
—
—
0
0
123
1084
1.31
1.17
3.6
3.5
63.25
58.39
u/l
0.23
114
1002
73
600
1.33
1.14
3.2
2.7
54.16
63.10
u/l
0.55
64
567
31
222
1.46
1.08
1.7
2.0
—
—
—
0
0
32
231
1.45
1.07
7.6
8.4
—
—
—
0
0
22
148
1.54
1.03
2.6
2.5
28.41
36.82
u/l
0.84
17
127
9
50
1.83
0.98
1.9
1.3
—
—
—
0
0
42
326
1.36
0.95
1.6
2.0
—
—
—
0
0
110
975
1.26
0.92
4.6
4.4
22.67
21.40
%
0.44
63
491
46
364
1.34
0.92
4.1
4.2
239.84
381.33
ng/l
0.28
38
318
6
28
2.17
0.92
1.0
1.5
—
—
—
0
0
6
29
2.10
0.90
2.2
1.5
1139.33
4284.32
e6/l
—
6
22
6
29
2.10
0.90
1.8
1.3
1.17
5.95
e6/l
—
6
22
30
223
1.40
0.88
1.8
2.0
—
—
—
0
0
16
104
1.58
0.87
4.2
2.9
1.30
1.25
%
0.09
16
104
6
31
1.96
0.85
1.5
1.2
—
—
—
0
0
108
971
1.23
0.75
19.9
17.4
1.33
1.33
inr
0.03
41
272
132
1212
1.23
0.75
5.6
5.2
3.07
2.89
ug/l
0.12
115
1074
44
359
1.28
0.72
1.6
1.7
1.26
1.56
mg/l
0.21
30
284
90
799
1.22
0.70
5.3
4.2
573.26
48.26
ng/l
0.47
75
619
15
102
1.51
0.69
4.3
2.8
0.64
0.70
%
0.30
15
102
49
411
1.25
0.64
1.8
1.8
389.42
415.60
pmol/l
0.37
36
345
12
81
1.51
0.58
1.8
2.9
—
—
—
0
0
5
89
0.55
0.57
2.0
4.1
14.60
2684.22
u/ml
—
5
77
50
429
1.22
0.54
2.3
2.4
—
—
—
0
0
28
227
1.27
0.50
1.4
1.2
35.60
44.73
iu/ml
—
8
74
7
45
1.57
0.49
2.0
1.6
—
—
—
0
0
26
211
1.26
0.46
1.3
1.3
1.11
17.13
u/ml
—
9
78
0
18
0.00
0.40
0.0
1.6
—
4.20
—
0
5
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
9
69
1.32
0.37
1.2
1.2
—
—
—
0
0
8
62
1.30
0.28
2.4
1.3
—
—
—
0
0
14
113
1.26
0.27
1.5
1.7
—
—
—
0
0
14
170
0.81
0.26
1.4
1.3
—
—
—
0
0
51
470
1.11
0.23
1.7
1.6
16.05
19.89
nmol/l
1.86
44
389
22
252
0.86
0.23
4.3
5.0
33.93
30.83
%
0.58
15
165
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
79
1.28
0.22
1.4
2.4
0.60
0.31
u/ml
—
5
44
5
40
1.26
0.22
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
14
117
1.21
0.21
3.8
3.2
0.12
0.18
e6/l
0.20
14
117
5
43
1.17
0.21
1.4
1.2
—
—
—
0
0
5
43
1.17
0.21
1.4
1.2
—
—
—
0
0
23
203
1.15
0.20
1.7
2.3
11.29
13.00
nmol/l
0.37
16
181
6
53
1.14
0.19
1.3
1.8
—
—
—
0
0
24
215
1.13
0.17
3.5
3.6
—
—
—
0
0
7
63
1.11
0.17
1.3
1.2
—
—
—
0
0
8
69
1.17
0.16
2.8
1.3
—
—
—
0
0
74
706
1.07
0.16
3.3
3.1
0.99
0.84
ug/l
0.51
53
483
7
89
0.78
0.15
1.6
1.8
—
—
—
0
0
16
146
1.10
0.08
2.8
3.6
0.29
1.74
mmol/l
—
9
111
8
76
1.05
0.07
1.6
1.9
—
—
—
0
0
15
142
1.06
0.02
1.3
1.6
—
—
—
0
0
30
299
1.00
0.00
1.4
1.2
0.90
1.74
u/ml
—
6
84
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
0.00
1.6
2.2
—
—
—
0
0
6
59
1.02
-0.00
1.8
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
951.25
—
0
8
7
76
0.92
-0.00
2.6
3.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
9.18
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
85.29
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
199.14
—
0
7
0
7
0.00
-0.00
0.0
2.4
—
13.71
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
6
61
0.98
-0.00
1.8
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
2.2
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_RHINOPHYMA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_RHINOPHYMA | 1.076 [0.9, 1.29] | 0.435 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 774 males with L12_RHINOPHYMA died.
Mortality risk
Mortality risk for people of age
years, who have L12_RHINOPHYMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.243% |
| 5 | No data | 1.406% |
| 10 | No data | 3.532% |
| 15 | No data | 6.807% |
| 20 | No data | 11.741% |
Relationships between endpoints
↥Index endpoint: L12_RHINOPHYMA – Rhinophyma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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