Fatigue fracture of vertebra

M13_FATIGFRACT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M48.4
  • Cause of death: ICD-10 M48.4

2 out of 7 registries used, show all original rules.

178

4. Check minimum number of events

None

178

5. Include endpoints

None

178

6. Filter based on genotype QC (FinnGen only)

176

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Fractura vertebrae ex fatigatione

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1686 892 789
Only index persons 1561 823 738
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 40.97 61.05 18.09
Only index persons 40.52 60.94 17.75

-FinnGen-

Key figures

All Female Male
Number of individuals 176 112 64
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 63.25 63.37 63.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
178
Matched controls
1780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.4
ICD-10 Finland
Fatigue fracture of vertebra
+∞
254.3
177
*
M54.5
ICD-10 Finland
Low back pain
11.5
62.1
106
202
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
19.3
49.3
42
28
M48.0
ICD-10 Finland
Spinal stenosis
70.3
42.0
47
9
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
85.2
41.4
45
7
M54.4
ICD-10 Finland
Lumbago with sciatica
10.8
40.2
51
64
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.5
34.4
54
87
N03AX12
ATC
[U] gabapentin; oral
8.3
32.4
51
82
N03AX16
ATC
[U] pregabalin
6.8
31.5
65
139
M54.9
ICD-10 Finland
Dorsalgia, unspecified
9.7
29.8
39
50
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
82.4
25.6
28
*
M05BA04
ATC
alendronic acid; oral
6.9
25.6
47
88
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
35.1
25.1
32
11
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
262.4
23.2
23
*
N02AX02
ATC
tramadol; systemic, rectal
4.4
21.3
94
363
N02AA05
ATC
oxycodone; systemic
4.6
18.5
56
161
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
199.0
17.9
18
*
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
22.1
17.5
25
13
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.6
15.8
87
374
L03
ICPC
Low back symptom/complaint
3.8
14.8
59
204
M05BX04
ATC
denosumab; parenteral
6.4
14.6
26
46
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.2
14.0
22
34
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
81.2
13.8
15
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.3
13.7
88
409
N02BF01
ATC
gabapentin; oral
7.0
13.6
22
35
N06AA09
ATC
amitriptyline; systemic
5.9
13.4
26
50
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
19.1
12.8
19
11
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
14.7
12.8
21
16
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
40.6
12.4
15
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.7
12.1
24
47
A02BC05
ATC
esomeprazole; systemic
3.0
11.5
82
395
N02AJ06
ATC
codeine and paracetamol; systemic
3.0
11.4
83
404
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
19.4
10.9
16
9
N06AX21
ATC
duloxetine; oral
4.7
10.8
27
65
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
63.9
10.8
12
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
63.9
10.8
12
*
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
10.5
10
*
M25.5
ICD-10 Finland
Pain in joint
2.9
10.2
65
292
M01AH02
ATC
rofecoxib; oral
3.9
9.9
33
99
M54
ICD-10 Finland
Dorsalgia
4.4
9.8
27
70
L04AX03
ATC
methotrexate; systemic
4.2
9.8
28
75
M01AH01
ATC
celecoxib; oral
3.5
9.5
38
129
M43.0
ICD-10 Finland
Spondylolysis
+∞
9.5
9
*
M03BX02
ATC
tizanidine; oral
2.7
9.3
102
598
P01BA02
ATC
hydroxychloroquine; oral
4.2
9.0
26
70
SPAT1234
SPAT
Support of social functional capacity
5.2
8.8
19
40
M43.1
ICD-10 Finland
Spondylolisthesis
52.6
8.8
10
*
SPAT1229
SPAT
Assessment of need for aid
4.7
8.7
21
49
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.4
8.6
23
58
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.9
8.6
49
205
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.3
8.5
23
59
L95
ICPC
Osteoporosis
8.2
8.4
18
24
M47.9
ICD-10 Finland
Spondylosis, unspecified
+∞
8.4
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
8.4
48
201
M79.6
ICD-10 Finland
Pain in limb
2.5
8.3
82
450
M05BB03
ATC
alendronic acid and colecalciferol; oral
9.6
8.2
16
18
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
12.5
8.2
14
12
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
18.2
8.2
12
7
L28
ICPC
Limited function/disability (L)
3.0
8.1
44
178
AA1AD
NOMESCO Finland
CT of head and brain
2.6
7.9
60
290
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
16.0
7.8
12
8
M03BC01
ATC
orphenadrine (citrate); systemic
3.1
7.8
38
145
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
7.7
44
183
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
7.6
47
204
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
83.4
7.5
8
*
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
83.4
7.5
8
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.9
7.4
23
65
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.4
39
155
A28
ICPC
Limited function/disability NOS
2.7
7.3
49
221
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
7.3
22
61
H02AB06
ATC
prednisolone; systemic
2.4
7.2
88
523
R03AC02
ATC
salbutamol; inhalant
2.4
7.1
108
704
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
7.0
41
172
L86
ICPC
Back syndrome with radiating pain
8.8
7.0
14
17
L76
ICPC
Fracture: other
6.6
7.0
17
28
A01
ICPC
Pain general/multiple sites
3.7
7.0
23
68
S32.1
ICD-10 Finland
Fracture of sacrum
41.7
6.8
8
*
B01AB05
ATC
enoxaparin; parenteral
2.4
6.8
62
323
A02BC02
ATC
pantoprazole; systemic
2.4
6.8
117
799
SPAT1254
SPAT
Administration of medicine
2.7
6.7
42
182
SPAT1212
SPAT
Extensive examination of musculoskeletal system
4.0
6.7
20
55
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
6.6
19
51
TAC99
NOMESCO Finland
Other blockade for chronic pain
72.3
6.5
7
*
M70.6
ICD-10 Finland
Trochanteric bursitis
3.2
6.5
28
99
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.4
88
542
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
6.4
29
105
H02AB07
ATC
prednisone; oral
3.0
6.4
30
111
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
7.5
6.4
14
20
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
6.3
73
419
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
6.3
6
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.2
6.3
27
95
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
6.2
41
183
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
6.2
72
414
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.2
6.1
17
44

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
117
702
2.95
10.68
7.5
6.8
1.20
1.22
mmol/l
1.72
107
612
107
667
2.51
8.21
7.6
6.2
2.82
2.88
%
0.10
100
637
38
142
3.13
8.05
7.4
6.9
12.22
12.93
kpa
0.37
38
137
107
671
2.49
8.04
8.2
6.5
9.10
8.64
%
0.65
99
643
108
681
2.49
8.01
7.5
6.2
56.65
55.58
%
0.42
101
652
104
645
2.47
7.99
8.1
6.4
0.66
0.66
%
0.03
97
611
111
712
2.49
7.88
7.2
6.3
1.82
2.06
e9/l
0.75
100
636
108
692
2.43
7.57
7.2
6.2
0.04
0.04
e9/l
0.38
96
604
102
645
2.36
7.26
7.2
6.7
—
—
—
0
0
107
692
2.37
7.22
8.2
6.3
28.38
29.35
%
0.39
101
663
109
712
2.37
7.16
7.8
6.9
0.18
0.19
e9/l
0.20
99
627
63
326
2.44
7.05
5.2
3.9
—
—
—
0
0
137
998
2.62
6.95
5.4
3.7
13.80
12.40
mm/h
0.36
126
907
128
907
2.46
6.84
6.9
3.9
—
—
—
0
0
41
176
2.73
6.70
2.0
1.8
—
—
—
0
0
105
693
2.26
6.50
7.5
6.2
0.62
0.57
e9/l
1.33
93
605
22
70
3.45
5.97
6.7
10.0
93.95
94.93
%
0.45
22
70
116
815
2.22
5.93
10.1
9.8
3.95
3.93
e9/l
0.03
103
717
73
431
2.18
5.79
3.0
2.3
—
—
—
0
0
23
77
3.28
5.77
6.4
9.1
0.62
0.72
%
0.58
23
77
23
77
3.28
5.77
6.3
9.1
1.60
1.25
%
0.62
23
77
136
1031
2.35
5.61
9.6
6.5
80.83
86.15
u/l
0.54
131
955
32
137
2.63
5.20
6.1
9.1
—
—
—
0
0
89
586
2.04
5.14
5.2
4.5
35.33
35.73
g/l
0.28
81
549
63
365
2.12
5.14
4.4
3.1
—
—
—
0
0
47
252
2.18
4.62
1.8
1.6
1126.41
1148.20
nmol/l
0.06
36
188
47
252
2.18
4.62
4.1
3.0
2.46
2.46
mmol/l
0.17
39
225
68
422
1.99
4.51
5.0
3.0
—
—
—
0
0
76
493
1.95
4.41
4.9
3.7
39.00
47.89
ng/l
0.19
53
350
34
162
2.36
4.40
5.7
7.1
104.53
104.62
mmol/l
0.03
34
162
55
320
2.04
4.34
2.4
3.1
4855.12
7734.80
umol/l
0.23
43
283
74
478
1.94
4.34
3.5
2.9
2.33
2.36
mmol/l
1.39
58
427
92
639
1.91
4.33
23.8
12.5
1.21
1.29
inr
0.34
18
198
18
62
3.12
4.31
9.7
11.2
—
—
—
0
0
62
380
1.97
4.21
4.5
3.1
0.20
0.39
e6/l
1.21
54
288
33
159
2.32
4.16
1.2
1.2
—
—
—
0
0
14
42
3.53
4.14
3.4
3.3
—
—
—
0
0
21
82
2.77
4.06
2.0
2.1
—
—
—
0
0
159
1365
2.54
3.80
24.6
13.0
25.93
23.91
mg/l
0.24
134
1038
49
291
1.94
3.58
3.5
2.9
575.24
571.13
mosm/kgh2o
0.04
42
256
37
199
2.08
3.55
1.2
1.2
29.35
43.59
iu/ml
—
6
65
66
435
1.82
3.49
4.5
3.1
14.33
205.58
e6/l
0.71
56
337
26
122
2.32
3.47
4.5
4.4
—
—
—
0
0
75
522
1.75
3.26
2.4
1.9
93.05
93.58
pmol/l
0.03
45
264
8
15
5.53
3.23
3.3
2.5
—
—
—
0
0
14
50
2.95
3.17
1.9
4.2
0.20
0.19
g/l
—
7
27
71
492
1.74
3.10
5.1
3.7
33.72
115.51
e6/l
2.13
61
356
61
407
1.76
3.03
4.9
3.4
7.38
7.40
ph
—
6
68
19
85
2.38
2.82
8.3
4.2
—
—
—
0
0
70
498
1.67
2.71
2.4
2.1
—
—
—
0
0
33
188
1.93
2.69
1.4
1.2
7.79
12.41
u/ml
0.21
15
68
22
109
2.16
2.59
2.1
2.5
4.33
5.60
ug/l
0.67
16
95
55
373
1.69
2.52
2.6
2.4
2.77
3.05
mg/l
0.57
48
322
8
21
3.94
2.49
3.9
4.4
—
—
—
0
0
11
38
3.02
2.46
1.2
1.0
—
—
—
0
0
6
12
5.13
2.42
1.3
1.8
12.74
22.91
ug/l
—
6
12
28
157
1.93
2.39
1.5
1.4
414.55
372.57
titre
0.11
11
35
27
152
1.92
2.28
2.0
1.6
—
—
—
0
0
55
382
1.64
2.28
7.6
6.4
—
—
—
0
0
11
41
2.79
2.25
1.0
1.1
—
—
—
0
0
24
132
1.95
2.17
1.3
1.2
—
—
—
0
0
77
589
1.54
2.09
3.3
2.8
112.71
109.41
ug/l
0.06
68
543
14
64
2.29
2.00
1.4
1.2
—
—
—
0
0
17
85
2.11
1.98
1.1
1.3
328.83
193.43
iu/ml
—
6
40
122
1043
1.54
1.90
4.9
3.9
14.67
14.90
pmol/l
0.42
109
935
5
12
4.25
1.83
1.2
1.1
—
—
—
0
0
5
12
4.25
1.83
1.0
1.3
—
—
—
0
0
167
1556
2.19
1.77
33.2
19.5
6.68
6.61
e9/l
0.14
161
1500
48
343
1.55
1.73
1.5
1.5
1.42
1.31
u/ml
0.06
13
69
5
13
3.92
1.72
1.0
1.7
—
—
—
0
0
35
232
1.63
1.72
3.9
2.9
1.90
3.14
e6/l
0.56
21
141
157
1437
1.78
1.72
20.4
12.2
—
—
—
0
0
13
62
2.18
1.70
2.7
2.7
—
—
—
0
0
6
19
3.23
1.67
1.0
1.1
—
—
—
0
0
5
14
3.64
1.62
2.8
3.6
2.38
4.86
nmol/l
—
5
14
10
44
2.35
1.58
4.9
3.5
3.65
4.05
mmol/l
—
10
44
32
458
0.63
1.54
2.2
3.0
—
—
—
0
0
5
15
3.40
1.53
1.2
1.1
—
—
—
0
0
166
1556
1.99
1.51
33.4
19.7
38.81
39.50
%
0.64
154
1462
20
119
1.77
1.45
1.9
1.7
—
—
—
0
0
44
321
1.49
1.43
2.1
1.5
17.88
20.77
nmol/l
0.69
39
266
6
23
2.66
1.38
1.2
1.3
—
—
—
0
0
157
1459
1.64
1.33
13.7
9.5
22.09
24.49
u/l
1.84
149
1398
77
634
1.38
1.28
4.9
3.7
0.00
0.00
estimate
—
10
135
13
70
1.92
1.27
1.2
1.2
—
—
—
0
0
78
644
1.38
1.27
6.7
5.2
0.00
0.00
estimate
—
9
124
6
25
2.45
1.25
1.3
2.8
—
—
—
0
0
20
125
1.68
1.24
2.9
9.9
24.54
24.98
mmol/l
0.20
20
125
8
38
2.16
1.20
1.3
1.2
—
—
—
0
0
6
26
2.35
1.19
1.2
1.2
55.33
39.12
nmol/l
—
6
26
15
88
1.77
1.15
5.7
3.7
—
—
—
0
0
140
1283
1.43
1.13
6.0
4.6
2.02
1.96
mu/l
0.19
131
1158
62
504
1.35
1.09
4.3
3.5
6.08
5.83
ph
—
6
30
14
82
1.77
1.08
6.2
6.3
24.77
25.26
mmol/l
0.21
14
82
26
180
1.52
1.08
4.3
6.8
—
—
—
0
0
19
122
1.62
1.08
2.9
3.0
70.11
63.15
e9/l
0.41
14
97
9
46
2.01
1.05
3.0
2.1
—
—
—
0
0
9
50
1.84
0.98
7.1
4.3
—
—
—
0
0
17
109
1.62
0.97
1.5
1.6
—
—
—
0
0
9
51
1.80
0.96
1.7
2.4
25.42
16.40
iu/l
—
9
39
76
648
1.30
0.94
5.0
3.8
0.00
0.02
estimate
—
8
123
6
28
2.18
0.92
2.8
2.5
—
—
—
0
0
22
154
1.49
0.88
1.4
1.3
—
—
—
0
0
6
115
0.51
0.86
5.8
3.5
—
—
—
0
0
10
57
1.80
0.85
1.8
1.2
—
—
—
0
0
36
281
1.35
0.81
4.9
3.5
—
—
—
0
0
8
48
1.70
0.80
1.8
2.4
13.90
7.07
u/l
—
8
35
6
33
1.85
0.80
1.7
13.5
—
—
—
0
0
24
176
1.42
0.78
1.2
1.2
—
—
—
0
0
25
185
1.41
0.77
2.1
2.9
105.81
93.33
ug/g
0.14
16
133
9
53
1.73
0.77
1.1
1.6
—
—
—
0
0
19
134
1.47
0.75
5.8
6.7
9.71
8.43
mmol/l
0.31
19
123
14
92
1.57
0.75
5.1
6.0
—
—
—
0
0
39
314
1.31
0.72
1.5
1.5
2.13
2.15
g/l
0.03
15
166
41
343
1.25
0.57
4.9
4.7
2.55
3.14
ug/l
0.20
36
309
6
39
1.56
0.53
6.3
9.1
—
—
—
0
0
10
67
1.52
0.51
2.3
7.9
0.79
0.66
%
—
10
67
74
667
1.19
0.49
10.8
9.4
0.00
0.00
e9/l
0.58
60
554
30
361
0.80
0.49
1.5
1.5
1.14
1.27
mmol/l
0.61
21
300
33
275
1.25
0.48
1.5
1.8
504.86
451.79
pmol/l
0.24
22
224
46
401
1.20
0.44
3.7
3.8
—
—
—
0
0
34
289
1.22
0.42
6.1
3.8
1.02
1.02
kg/l
—
10
48
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
6
43
1.41
0.35
2.0
3.0
—
—
—
0
0
35
393
0.86
0.29
1.4
1.4
—
—
—
0
0
11
88
1.27
0.23
1.3
1.3
—
—
—
0
0
136
1322
1.12
0.23
4.6
4.8
2.53
2.66
mmol/l
1.02
124
1209
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
6.99
—
0
10
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
20.6
—
1534.86
—
0
14
0
14
0.00
0.20
0.0
15.3
—
829.93
—
0
14
17
147
1.17
0.19
1.2
1.2
—
—
—
0
0
46
428
1.10
0.18
2.8
3.3
7.55
7.58
mmol/l
0.01
38
369
5
67
0.74
0.17
2.8
11.5
1.31
1.43
mg/l
—
5
62
9
78
1.16
0.15
2.7
3.9
—
—
—
0
0
38
407
0.92
0.15
3.4
3.9
25.81
8.67
mg/mmol
0.43
23
269
9
106
0.84
0.13
4.4
3.4
1.21
1.22
mmol/l
—
9
88
127
1293
0.94
0.11
4.3
4.3
4.46
4.58
mmol/l
0.58
116
1193
40
379
1.07
0.10
3.3
3.2
1602.31
55.92
mg/l
0.51
26
260
14
125
1.13
0.10
2.2
1.5
—
—
—
0
0
124
1219
1.06
0.09
5.7
5.9
38.90
40.57
mmol/mol
1.41
115
1123
11
98
1.13
0.08
4.1
3.5
—
—
—
0
0
131
1292
1.05
0.08
4.6
4.4
5.73
6.02
mmol/l
1.99
118
1167
125
1232
1.05
0.07
3.9
3.9
1.22
1.23
mmol/l
0.06
115
1121
16
173
0.92
0.07
1.6
1.7
—
—
—
0
0
10
106
0.94
0.01
1.3
1.6
—
—
—
0
0
12
126
0.95
0.00
1.5
1.6
—
—
—
0
0
13
134
0.97
0.00
1.5
1.6
—
—
—
0
0
34
339
1.00
0.00
6.5
3.8
0.00
0.00
estimate
—
8
125
94
942
1.00
0.00
4.1
3.6
—
—
—
0
0
21
213
0.98
0.00
1.9
1.8
—
—
—
0
0
37
375
0.98
0.00
5.1
3.5
—
—
—
0
0
128
1282
0.99
0.00
4.4
4.2
1.49
1.50
mmol/l
0.02
118
1172
5
55
0.91
0.00
1.2
1.6
—
—
—
0
0
7
70
1.00
-0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
185.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
11.86
—
0
8
5
54
0.92
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
140.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
1.60
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
7.0
—
0.63
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
2.61
—
0
7
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
185.33
—
0
6
7
72
0.97
-0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_FATIGFRACT and mortality.

Females

Parameter HR [95% CI] p-value
M13_FATIGFRACT 1.518 [1.15, 2.0] 0.003
Birth year 0.996 [0.99, 1.0] 0.403

During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 579 females with M13_FATIGFRACT died.

Males

Parameter HR [95% CI] p-value
M13_FATIGFRACT 1.865 [1.31, 2.66] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 387 males with M13_FATIGFRACT died.

Mortality risk

Mortality risk for people of age

years, who have M13_FATIGFRACT.

N-year risk Females Males
1 0.183% 0.329%
5 0.973% 1.964%
10 2.401% 4.885%
15 4.479% 8.956%
20 7.785% 15.13%

Relationships between endpoints

Index endpoint: M13_FATIGFRACT – Fatigue fracture of vertebra

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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