Fatigue fracture of vertebra

M13_FATIGFRACT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.4 Cause of death: ICD-10 — M48.4 2 out of 7 registries used, show all original rules.	165
4. Check minimum number of events None	165
5. Include endpoints None	165
6. Filter based on genotype QC (FinnGen only)	165

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M48
Name in latin: Fractura vertebrae ex fatigatione

NAME	M13_FATIGFRACT
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M484
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M484
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fatigue fracture of vertebra based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1686	892	789
Only index persons	1561	823	738
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	40.97	61.05	18.09
Only index persons	40.52	60.94	17.75

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	165	103	62
Unadjusted period prevalence (%)	0.03	0.04	0.03
Median age at first event (years)	62.68	62.70	62.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
143: Matched controls
1430

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.4

ICD-10 Finland

Fatigue fracture of vertebra

4503599627370496.0

201.3

142

M48.0

ICD-10 Finland

Spinal stenosis

177.0

38.9

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

42.3

27.0

M54.5

ICD-10 Finland

Low back pain

7.7

25.8

174

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

90.3

21.4

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

57.1

20.9

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

22.4

20.1

M54.4

ICD-10 Finland

Lumbago with sciatica

11.1

19.3

N03AX16

ATC

pregabalin; oral

7.0

18.8

107

M54.9

ICD-10 Finland

Dorsalgia, unspecified

14.9

18.4

N03AX12

ATC

gabapentin; oral

9.0

17.9

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

72.4

17.2

N02AA05

ATC

oxycodone; systemic

6.2

15.1

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.9

15.0

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

18.5

12.0

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

130.0

11.6

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

130.0

11.6

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.7

11.3

258

L03

ICPC

Low back symptom/complaint

4.0

10.3

150

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

43.4

10.1

M05BA04

ATC

alendronic acid; oral

5.0

10.1

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

10.2

9.9

N02AX02

ATC

tramadol; systemic, rectal

3.3

9.8

303

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.3

9.8

304

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

106.8

9.5

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

106.8

9.5

M54.3

ICD-10 Finland

Sciatica

29.5

8.6

M43.1

ICD-10 Finland

Spondylolisthesis

95.4

8.5

M25.5

ICD-10 Finland

Pain in joint

3.3

8.3

196

N02AJ06

ATC

codeine and paracetamol; systemic

3.1

8.3

258

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

35.6

8.2

M81.9

ICD-10 Finland

Osteoporosis, unspecified

8.2

7.9

M84.3

ICD-10 Finland

Stress fracture, not elsewhere classified

47.6

7.8

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

19.7

7.7

A02BC05

ATC

esomeprazole; systemic

2.8

7.5

337

TAC99

NOMESCO Finland

Other blockade for chronic pain

+∞

7.3

M43.0

ICD-10 Finland

Spondylolysis

+∞

7.3

M05BX04

ATC

denosumab; parenteral

7.7

7.2

N06AA09

ATC

amitriptyline; systemic

5.4

7.2

M54

ICD-10 Finland

Dorsalgia

4.9

7.1

Z01.8

ICD-10 Finland

Other specified special examinations

3.4

7.1

139

L02

ICPC

Back symptom/complaint

5.3

6.5

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

6.3

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

6.3

NAG40

NOMESCO Finland

Anterior fusion of cervical spine without fixation

+∞

6.3

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

10.7

6.1

J01DA01

ATC

[U] cefalexin; systemic

2.4

6.1

521

M05BB03

ATC

alendronic acid and colecalciferol; oral

7.8

6.1

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

4.4

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

106

647

2.79

9.08

7.2

6.8

mmol/l

1.2

1.77

560

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

284

2.75

8.39

2.6

2.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

592

2.61

8.31

7.2

6.6

mmol/l

1.2

1.75

540

(3027801) Oxygen [Partial pressure] in Arterial blood

130

3.26

8.13

7.6

6.6

kpa

12.3

12.9

0.27

125

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

522

2.47

7.52

2.8

2.4

nmol/l

77.8

75.2

0.36

462

(3014111) Lactate [Moles/volume] in Serum or Plasma

107

3.34

7.50

4.6

10.3

mmol/l

1.2

1.5

0.85

100

(3023368) Bacteria identified in Blood by Culture

302

2.55

7.26

5.1

3.9

—

(3006504) Eosinophils/100 leukocytes in Blood

621

2.42

7.09

6.9

6.4

2.8

2.9

0.15

587

(3019198) Lymphocytes [#/volume] in Blood

102

660

2.43

7.01

6.4

6.3

e9/l

1.9

2.1

0.65

581

(3018010) Neutrophils/100 leukocytes in Blood

633

2.41

6.98

6.7

6.3

56.4

55.6

0.30

602

(3019069) Monocytes/100 leukocytes in Blood

624

2.40

6.97

7.4

6.6

8.9

8.6

0.34

597

(42870588) Differential panel, method unspecified - Blood

442

2.39

6.93

6.9

6.5

—

(3022096) Basophils/100 leukocytes in Blood

603

2.36

6.72

7.4

6.5

0.6

0.7

0.07

571

(3006315) Basophils [#/volume] in Blood

644

2.34

6.56

6.4

6.3

e9/l

0.0

0.34

555

(3037467) Urinalysis macro (dipstick) panel - Urine

118

829

2.49

6.55

6.4

4.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

126

920

2.56

6.30

5.3

3.8

mm/h

13.4

12.2

0.29

115

834

(3002030) Lymphocytes/100 leukocytes in Blood

643

2.29

6.26

7.4

6.4

28.9

29.4

0.14

610

(3013115) Eosinophils [#/volume] in Blood

100

662

2.30

6.24

7.0

6.9

e9/l

0.2

0.20

578

(3001604) Monocytes [#/volume] in Blood

642

2.18

5.63

6.7

6.3

e9/l

0.6

1.13

552

(3013650) Neutrophils [#/volume] in Blood by Automated count

107

754

2.19

5.41

9.5

e9/l

4.0

0.03

659

(3014007) Fractional oxyhemoglobin in Arterial blood

3.36

5.27

6.9

10.3

93.9

94.9

0.37

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

125

945

2.33

5.21

9.4

6.3

u/l

78.3

86.7

1.64

120

877

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.05

5.09

1.2

1.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.20

5.09

6.4

9.4

1.6

1.2

0.54

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.20

5.09

6.6

9.4

0.6

0.7

0.40

(3024561) Albumin [Mass/volume] in Serum or Plasma

541

2.07

5.03

5.0

4.5

g/l

35.2

35.7

0.30

507

(3042936) Bacteria identified in Isolate by Culture

160

2.51

5.01

2.0

1.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

228

2.27

4.76

1.8

1.6

nmol/l

1141.0

1128.2

0.03

173

(3000991) Gas panel - Venous blood

132

2.56

4.63

4.6

9.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

553

2.01

4.62

4.6

3.7

—

(3044640) Blood type and Crossmatch panel - Blood

398

2.04

4.57

3.0

2.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.77

4.36

1.6

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.77

4.36

1.6

1.5

—

(3023419) Bacteria identified in Sputum by Culture

9.27

4.33

3.0

2.6

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

3.14

4.32

6.5

9.5

mmol/l

24.1

23.8

0.13

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

230

2.18

4.27

4.2

3.1

mmol/l

2.5

0.16

204

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.21

4.26

9.9

10.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

441

1.97

4.24

3.5

3.0

mmol/l

2.3

2.4

1.36

387

(3026008) Bacteria identified in Urine by Culture

376

1.99

4.14

5.0

3.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

453

1.95

4.12

4.9

3.8

ng/l

39.0

50.4

0.23

325

(36304419) Bacteria [Presence] in Urine

351

1.95

3.83

4.1

3.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

463

1.89

3.79

4.4

3.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

146

1256

2.41

3.36

24.1

13.0

mg/l

26.5

24.1

0.27

123

953

(40768797) Stomach Pathology biopsy report

153

2.17

3.31

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

125

2.28

3.30

1.9

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

295

1.88

3.18

2.4

3.3

umol/l

321.3

8486.2

2.01

257

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.75

3.15

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

363

1.82

3.13

4.2

3.2

e6/l

0.2

0.4

1.21

274

(3019060) Gas panel - Arterial blood

2.57

3.09

8.6

3.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

7.73

3.08

1.3

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

180

2.04

3.07

1.1

1.2

iu/ml

29.6

38.4

—

(3019225) pH of Specimen

109

2.29

3.02

4.8

4.5

—

(3026782) Osmolality of Urine

270

1.86

2.90

3.2

2.8

mosm/kgh2o

578.3

581.0

0.02

234

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

185

1.98

2.84

2.2

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

488

1.71

2.81

2.4

1.9

pmol/l

93.8

93.2

0.04

243

(3004588) Protein electrophoresis panel - Serum or Plasma

2.44

2.79

2.1

2.2

—

(3002582) Erythrocytes [#/volume] in Urine

413

1.71

2.67

4.2

3.2

e6/l

14.4

213.2

0.70

322

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

361

1.74

2.66

3.2

3.7

ng/l

1202.6

1447.5

0.40

313

(3032080) INR in Blood by Coagulation assay

494

1.68

2.65

11.5

7.9

inr

1.2

1.3

0.72

148

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.03

2.63

1.5

1.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

5.61

2.56

1.3

1.8

ug/l

12.7

23.2

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

7.32

2.56

2.4

2.7

ug/l

44.9

266.4

—

(3037121) Protein [Mass/volume] in Urine

2.80

2.51

2.1

3.9

g/l

0.1

0.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

2.06

2.46

2.0

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.28

2.45

2.1

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.46

2.29

1.0

1.3

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

4.01

2.28

1.9

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

349

1.67

2.27

2.7

2.5

mg/l

2.9

3.0

0.26

299

(40768804) Tissue Pathology biopsy report

449

1.61

2.20

2.4

2.2

—

(3018095) Leukocytes [#/volume] in Urine

468

1.60

2.18

4.7

3.8

e6/l

32.5

114.5

2.03

342

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

171

1.84

2.15

1.3

1.2

u/ml

1.8

6.2

1.07

(3052851) Hemolysis interference index of Serum or Plasma

2.67

2.14

3.5

—

(3018418) pH of Serum or Plasma

381

1.62

2.12

4.1

3.4

7.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

546

1.57

2.08

2.9

2.8

ug/l

108.0

108.4

0.01

500

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

749

1.55

2.05

4.0

3.3

u/l

45.3

45.5

0.01

702

(40760888) Immunoglobulin light chains.free panel - Serum

3.43

1.99

4.3

4.4

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.82

1.96

1.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

4.65

1.95

3.4

3.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

796

1.53

1.91

3.2

3.0

—

(40768443) Skin Pathology biopsy report

2.31

1.89

1.3

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

139

1.85

1.88

2.0

1.5

—

(3037522) Nuclear Ab [Titer] in Serum

147

1.83

1.87

1.4

titre

424.0

377.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

4.26

1.83

2.8

4.1

nmol/l

2.4

4.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.66

1.83

1.0

1.1

—

(36660697) Celiac disease serology panel - Serum

126

1.86

1.79

1.3

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.58

1.77

1.0

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

3.42

1.76

1.0

1.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

104

1.93

1.76

2.2

2.6

ug/l

4.4

5.8

0.69

(3017732) Neutrophils [#/volume] in Blood

2.16

1.76

2.5

3.1

e9/l

3.4

3.7

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.10

1.76

1.1

1.3

iu/ml

372.4

170.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.75

1.75

2.0

1.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.38

1.74

2.5

2.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.93

1.72

1.8

1.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.93

1.72

1.8

1.9

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.93

1.72

1.8

1.9

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

3.93

1.72

1.8

1.9

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

3.65

1.62

1.8

1.9

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.65

1.62

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

3.65

1.62

1.8

1.9

—

(3010813) Leukocytes [#/volume] in Blood

154

1434

2.11

1.62

32.5

19.6

e9/l

6.7

6.6

0.20

148

1385

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

111

957

1.49

1.58

4.9

3.9

pmol/l

14.7

14.9

0.21

859

(1761868) Lipid panel - Serum or Plasma

410

0.62

1.51

2.4

3.1

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

126

1.76

1.49

4.2

4.4

31.5

33.1

0.31

(40761511) CBC panel - Blood by Automated count

144

1321

1.71

1.49

21.1

12.2

—

(3008898) HLA-B27 [Presence]

2.45

1.48

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.25

1.43

1.5

1.8

—

(40758558) Short blood count panel - Blood

367

1.48

1.42

7.5

6.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

219

1.57

1.40

3.6

3.0

e6/l

0.5

1.2

1.59

130

(3035637) Corticotropin [Mass/volume] in Plasma

2.67

1.38

1.2

1.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.00

1.37

1.2

1.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.04

1.36

2.8

2.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.87

1.25

6.2

5.6

mmol/l

24.8

25.2

0.18

(40761535) Cells panel - Urine sediment

1.87

1.25

5.9

3.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.45

1.25

1.3

2.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

110

1.71

1.21

2.1

1.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

144

1337

1.61

1.21

13.2

9.5

u/l

22.2

24.3

1.33

136

1282

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

129

1173

1.46

1.18

5.9

4.5

mu/l

2.0

0.02

120

1059

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.10

1.17

1.8

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.54

1.16

1.6

1.7

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.54

1.16

1.0

1.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

221

1.50

1.14

3.7

3.0

e6/l

2.1

3.1

0.40

135

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

105

1.69

1.11

5.5

5.1

kpa

5.2

0.07

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.82

1.10

1.8

3.0

ml/min/173m2

67.6

59.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.24

1.09

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

123

1.62

1.05

2.7

9.8

mmol/l

24.3

24.8

0.25

123

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

159

0.54

1.05

1.9

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

324

1.40

1.03

1.5

1.6

u/ml

1.5

1.0

0.32

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.98

0.0

1.1

—

110.2

—

(3023520) Reticulocytes [#/volume] in Blood

117

1.60

0.98

2.9

3.0

e9/l

71.6

63.3

0.48

(3022313) Gas panel - Capillary blood

1.71

0.98

5.1

5.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.81

0.96

1.1

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

582

1.32

0.95

4.7

3.8

estimate

0.0

—

112

(3000492) Spirometry study

102

1.63

0.94

1.4

1.6

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.27

0.94

1.2

nmol/l

55.3

39.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.90

0.88

1.4

1.1

—

(3045414) Leukocytes [Presence] in Urine

1.90

0.88

2.4

2.2

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.86

0.87

1.6

2.6

iu/l

28.0

14.6

—

(3025941) Bacteria identified in Stool by Culture

1.74

0.84

1.2

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.78

0.84

1.8

2.4

u/l

13.9

6.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

126

1166

1.34

0.83

26.5

15.5

38.9

39.0

0.07

868

(3020891) Body temperature

1.74

0.82

7.6

4.5

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.79

0.0

1.3

—

3.3

—

(3048689) Calprotectin [Mass/mass] in Stool

167

1.44

0.79

2.2

3.0

ug/g

108.7

97.9

0.11

120

(3021601) Nitrite [Presence] in Urine by Test strip

595

1.27

0.78

6.1

5.4

estimate

0.0

—

115

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.74

0.77

1.9

1.2

—

(40761536) Microorganisms panel - Urine sediment

108

0.54

0.75

5.8

3.3

—

(3009261) Glucose [Presence] in Urine by Test strip

600

1.26

0.71

4.7

3.8

estimate

0.0

—

113

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.88

0.69

1.6

1.4

—

(3012544) pH of Venous blood

172

1.39

0.68

2.7

7.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

129

1.44

0.67

12.0

6.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.81

0.66

1.6

2.3

—

(3002256) Pathology report gross observation

156

1.40

0.65

1.2

1.3

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

1.75

0.64

1.0

1.1

—

5.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

247

1.31

0.63

1.5

1.8

pmol/l

523.6

437.7

0.40

204

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

257

1.30

0.61

1.8

1.7

—

(4034850)

1.74

0.58

6.3

9.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

125

1.40

0.56

2.9

6.9

mmol/l

9.4

8.5

0.20

115

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

326

1.26

0.55

4.5

4.8

ug/l

2.6

3.2

0.17

292

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

333

0.77

0.55

1.5

mmol/l

1.2

1.3

0.25

276

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.52

0.52

3.5

2.0

—

(3013512) EKG study

357

1.24

0.52

3.8

3.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.41

0.51

2.7

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

293

1.25

0.49

1.5

g/l

2.2

2.1

0.02

151

(3000494) Fungus identified in Specimen by Culture

147

1.33

0.48

1.4

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

118

0.66

0.47

3.3

2.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.60

0.47

1.0

—

(3003694) ABO and Rh group [Type] in Blood

358

0.80

0.47

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

260

1.24

0.43

2.5

4.1

22.2

21.4

0.07

130

(3024928) Oxygen saturation in Venous blood

1.63

0.43

1.8

14.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

123

1.33

0.42

4.9

2.9

—

(40768806) Pleura Pathology biopsy report

0.00

0.41

0.0

1.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.41

0.0

1.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.41

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.39

0.0

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

126

1206

1.19

0.38

4.5

4.8

mmol/l

2.5

2.6

0.65

113

1104

(3017143) Hepatitis C virus Ab [Presence] in Serum

124

0.71

0.36

1.2

1.6

—

(3049717) Cytology report of Urine Cyto stain

1.44

0.36

2.0

3.0

—

(3022145) Colonoscopy Study observation

127

1.29

0.35

1.3

—

(3021589) Normoblasts [#/volume] in Blood

627

1.14

0.33

10.4

9.3

e9/l

0.0

0.58

515

(3009508) Creatinine [Moles/volume] in Urine

393

1.16

0.33

2.6

3.3

mmol/l

7.5

0.01

344

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.29

0.32

3.3

2.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

269

1.19

0.32

4.8

3.6

—

(3012516) Albumin [Mass/volume] in Urine

347

1.16

0.30

3.2

mg/l

1666.2

63.2

0.51

235

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.24

0.27

2.6

8.1

0.8

0.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.67

0.26

1.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

116

1121

1.12

0.23

3.8

3.9

mmol/l

1.2

0.03

106

1024

(3019150) Specific gravity of Urine by Refractometry

268

1.15

0.23

6.1

3.9

kg/l

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.8

—

(3012441) Differential panel - Pleural fluid

0.00

0.21

0.0

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.21

0.0

1.5

—

28.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

3.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

3.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

270

0.87

0.21

4.3

4.4

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.4

—

878.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

21.1

—

1622.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.75

0.17

1.4

1.5

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

0.76

0.17

2.8

11.6

mg/l

1.3

1.4

—

(3000330) Specific gravity of Urine by Test strip

1.13

0.16

2.0

4.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

106

0.84

0.13

2.7

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

105

0.85

0.13

1.7

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

157

0.88

0.11

1.4

1.7

—

(3044889) 12 lead EKG panel

870

0.95

0.08

3.9

3.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.06

0.08

1.4

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

120

1183

1.05

0.07

4.6

4.4

mmol/l

5.8

6.0

1.55

107

1074

(4010399)

1.06

0.07

1.2

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.02

0.07

1.2

1.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

100

0.89

0.06

4.4

3.5

mmol/l

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

113

1114

1.05

0.06

5.8

6.1

mmol/mol

39.3

40.6

0.93

105

1033

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

118

1168

1.04

0.04

4.3

4.2

mmol/l

1.5

0.32

107

1068

(3029937) Albumin [Presence] in Urine by Test strip

312

1.03

0.02

6.7

3.8

estimate

0.0

—

114

(3041096) Erythrocytes [Presence] in Urine by Automated

338

0.97

0.02

4.8

3.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

117

1177

0.98

0.01

4.2

4.3

mmol/l

4.4

4.5

0.61

105

1084

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

112

1113

1.02

0.01

23.1

12.6

ml/min/173m2

80.4

78.5

0.40

892

(4035726)

114

1.06

0.01

2.3

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

194

0.98

0.00

1.7

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

374

0.99

0.00

3.4

4.1

mg/mmol

26.9

9.5

0.41

245

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

117

1.03

0.00

1.9

2.2

1.7

1.5

0.41

105

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

465

0.99

0.00

6.0

4.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

5.7

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

2.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.3

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.96

0.00

1.2

1.5

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.1

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

2.2

—

140.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.6

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.89

0.00

2.1

3.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.84

0.00

1.2

1.4

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.3

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.0

2.2

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.0

—

185.2

—

(3024471) HLA-A [Type]

0.00

0.0

1.0

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(44806420)

0.00

0.0

2.8

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4198724)

0.00

0.0

1.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

203.0

—

(3022689) Creatine [Moles/volume] in Urine

0.00

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.98

0.00

1.2

1.5

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.8

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3024932) HLA-DR beta [Type]

0.00

0.0

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(4027681)

0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

3.3

—

7.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3027008) Opiates [Presence] in Urine

0.94

0.00

1.2

1.5

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

12.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.97

0.00

1.3

1.6

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.3

—

6.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

161.6

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

0.96

0.00

1.2

1.5

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

140.4

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.6

—

0.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FATIGFRACT and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FATIGFRACT	1.518 [1.15, 2.0]	0.003
Birth year	0.996 [0.99, 1.0]	0.403

During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 579 females with M13_FATIGFRACT died.

Males

Parameter	HR [95% CI]	p-value
M13_FATIGFRACT	1.865 [1.31, 2.66]	< 0.001
Birth year	0.984 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 387 males with M13_FATIGFRACT died.

Mortality risk

Mortality risk for people of age

years, who have M13_FATIGFRACT.

N-year risk	Females	Males
1	0.183%	0.329%
5	0.973%	1.964%
10	2.401%	4.885%
15	4.479%	8.956%
20	7.785%	15.13%

Relationships between endpoints

↥

Index endpoint: M13_FATIGFRACT – Fatigue fracture of vertebra

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fatigue fracture of vertebra

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints