Other fibroblastic disorders

M13_FIBROBLASTNAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M72.8, M72.9 Hospital discharge: ICD-9 — 7287X Cause of death: ICD-10 — M72.8, M72.9 Cause of death: ICD-9 — 7287X 2 out of 7 registries used, show all original rules.	139
4. Check minimum number of events None	139
5. Include endpoints None	139
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_FIBROBLASTNAS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M72[8-9]
HD_ICD_9	7287X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M72[8-9]
COD_ICD_9	7287X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other fibroblastic disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1061	528	526
Only index persons	957	489	468
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	51.89	50.70	52.89
Only index persons	50.79	49.57	52.07

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	72	67
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	51.04	47.99	54.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
128: Matched controls
1281

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M72.9

ICD-10 Finland

Fibroblastic disorder, unspecified

+∞

69.1

M72.8

ICD-10 Finland

Other fibroblastic disorders

+∞

39.6

7287X

ICD-9 Finland

Disorders of muscle, ligament and fascia, Other fibromatoses[FIBROMATOSIS ALIA MUSCULI,LIGAMENTI ET FASCIAE]

+∞

38.5

M72.0

ICD-10 Finland

Palmar fascial fibromatosis [Dupuytren]

+∞

36.1

NDM10

NOMESCO Finland

Palmar fasciotomy of hand

+∞

30.4

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

9.5

13.0

M79.6

ICD-10 Finland

Pain in limb

3.7

9.9

198

G72.9

ICD-10 Finland

Myopathy, unspecified

107.5

9.5

NHM10

NOMESCO Finland

Fasciotomy of ankle or foot

+∞

9.5

9476

FHL

Splitting of fascia or aponeurosis

96.0

8.5

N03AX12

ATC

gabapentin; oral

4.6

8.3

N02AX02

ATC

tramadol; systemic, rectal

2.9

7.3

309

M01AX17

ATC

nimesulide; oral

3.2

7.2

167

WX204

NOMESCO Finland

Axillary plexus blockaced

24.0

6.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.6

6.4

369

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.5

6.3

102

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002179) Metamyelocytes/100 leukocytes in Blood

2.70

3.76

4.4

4.1

0.0

0.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

730

2.02

3.57

4.5

3.8

—

(3000991) Gas panel - Venous blood

2.74

3.56

6.8

7.3

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.51

3.30

4.4

0.0

0.2

—

(3019198) Lymphocytes [#/volume] in Blood

516

1.87

3.28

7.0

5.9

1.8

e9/l

0.06

472

(3025159) Blasts/100 leukocytes in Blood

2.46

3.04

4.6

4.5

0.0

0.1

—

(3013115) Eosinophils [#/volume] in Blood

530

1.79

2.89

7.2

6.3

0.2

e9/l

2.15

478

(3007164) IgA [Mass/volume] in Serum or Plasma

193

2.01

2.89

1.5

2.4

2.3

g/l

0.14

115

(3017181) Myelocytes/100 leukocytes in Blood

2.35

2.88

4.4

4.3

0.3

0.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.23

2.88

1.3

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

209

1.98

2.87

4.8

3.1

—

(3006315) Basophils [#/volume] in Blood

512

1.79

2.87

7.2

5.7

0.0

e9/l

1.04

456

(42870588) Differential panel, method unspecified - Blood

325

1.84

2.84

6.7

5.9

—

(3002032) Base excess in Venous blood by calculation

2.37

2.83

5.0

2.7

3.3

2.2

mmol/l

0.39

(3024928) Oxygen saturation in Venous blood

4.40

2.72

5.1

3.0

—

(3001604) Monocytes [#/volume] in Blood

509

1.76

2.70

7.0

5.7

0.6

e9/l

0.08

453

(3000012) Reticulocyte production index

5.64

2.57

1.2

1.7

—

(4062490)

7.35

2.57

1.4

1.0

—

(3023520) Reticulocytes [#/volume] in Blood

2.34

2.54

2.1

3.3

83.9

67.2

e9/l

—

(36660697) Celiac disease serology panel - Serum

2.45

2.52

1.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

703

1.74

2.48

5.0

3.7

—

132.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

509

1.71

2.47

6.8

7.7

1.2

mmol/l

0.06

431

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

236

1.84

2.46

2.4

1.8

3.0

3.2

mg/l

0.40

198

(3012544) pH of Venous blood

2.19

2.40

5.0

2.9

—

(3009261) Glucose [Presence] in Urine by Test strip

523

1.68

2.35

4.7

3.4

0.0

estimate

0.00

110

(3035350) Ketones [Presence] in Urine by Test strip

515

1.67

2.32

4.7

3.3

0.0

estimate

0.00

116

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

460

1.68

2.30

6.5

6.7

1.2

mmol/l

0.07

421

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.04

2.28

2.1

2.4

3.4

4.3

e9/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

209

1.83

2.26

1.3

1.2

0.7

0.8

u/ml

—

(3021601) Nitrite [Presence] in Urine by Test strip

519

1.65

2.23

5.9

4.5

0.0

estimate

0.00

114

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

227

1.79

2.20

1.6

1.5

0.8

1.1

mg/l

0.64

180

(3026782) Osmolality of Urine

211

1.81

2.19

2.4

2.5

496.7

554.9

mosm/kgh2o

0.71

179

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.82

2.18

1.4

1.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.82

2.18

2.1

2.6

57.4

56.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.82

2.18

1.4

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

4.43

2.17

1.0

1.2

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

618

1.64

2.16

4.1

5.4

6.9

6.7

mmol/l

0.24

581

(3013650) Neutrophils [#/volume] in Blood by Automated count

619

1.64

2.14

8.0

10.4

4.6

4.0

e9/l

0.86

551

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

119

2.01

2.12

1.4

2.2

1.5

0.04

102

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

175

1.83

2.04

2.8

3.5

2.5

mmol/l

0.00

153

(3007853) Bacteria identified in Skin by Aerobe culture

2.06

2.02

3.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

143

0.33

2.02

1.0

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

160

1.85

2.00

1.4

1.2

25.6

45.3

iu/ml

0.81

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.37

1.97

4.5

5.0

25.9

25.2

mmol/l

0.21

(3004789) Transferrin [Mass/volume] in Serum or Plasma

146

1.87

1.94

2.9

1.9

2.5

2.4

g/l

0.71

132

(3022948) Iron [Moles/volume] in Serum or Plasma

156

1.82

1.86

2.9

1.9

10.2

13.8

umol/l

1.87

146

(3013707) Erythrocyte sedimentation rate by Westergren method

805

1.62

1.85

4.5

3.6

15.0

11.5

mm/h

0.78

742

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

116

1023

1.81

1.83

4.9

4.4

2.0

mu/l

0.00

109

933

(3029937) Albumin [Presence] in Urine by Test strip

282

1.64

1.82

4.3

3.5

0.0

estimate

0.50

115

(3023368) Bacteria identified in Blood by Culture

265

1.66

1.81

6.3

4.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

232

1.68

1.78

6.8

5.2

—

(3022145) Colonoscopy Study observation

112

1.92

1.76

1.5

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.49

1.72

2.1

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.09

1.72

1.5

1.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

100

855

1.60

1.70

6.7

7.4

77.1

79.4

u/l

0.31

798

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.67

1.69

2.4

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

261

1.63

1.69

2.5

2.8

347.8

9864.3

umol/l

2.03

221

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

153

1.77

1.68

1.1

1.2

2.4

20.4

u/ml

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.89

1.67

1.7

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.43

1.64

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.66

1.63

1.6

1.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

139

1.78

1.61

3.1

1.9

15.8

23.3

2.55

121

(3004588) Protein electrophoresis panel - Serum or Plasma

2.01

1.56

1.5

3.1

—

(4281824)

3.42

1.53

1.0

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

102

1.88

1.53

3.6

3.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

402

1.51

1.52

2.3

1.8

101.0

98.7

pmol/l

0.09

182

(40758558) Short blood count panel - Blood

268

1.58

1.50

3.7

7.0

—

(3019060) Gas panel - Arterial blood

2.07

1.49

3.2

11.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

167

1.69

1.48

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

160

1.69

1.44

2.0

1.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.09

1.43

6.6

8.5

90.2

92.5

0.35

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

416

1.49

1.42

4.2

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

237

1.58

1.41

2.7

2.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

145

1.70

1.40

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.68

1.38

1.2

1.6

—

(3021589) Normoblasts [#/volume] in Blood

485

1.46

1.36

11.5

10.2

0.0

e9/l

0.28

414

(3019309) Folate [Moles/volume] in Red Blood Cells

188

1.61

1.35

1.7

1043.3

1233.3

nmol/l

0.66

130

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.57

1.32

1.2

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

2.84

1.29

2.2

2.7

32.6

33.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

109

1.75

1.26

1.9

1.7

—

(3044889) 12 lead EKG panel

799

1.45

1.24

3.8

3.7

—

(3049717) Cytology report of Urine Cyto stain

2.06

1.14

2.4

3.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

113

1.68

1.12

1.8

1.6

—

(40768804) Tissue Pathology biopsy report

424

1.40

1.10

1.7

2.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

277

1.46

1.10

2.0

3.3

3975.7

1283.6

ng/l

0.55

231

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.99

1.09

3.3

2.0

1.1

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

139

1.60

1.08

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

114

1043

1.52

1.07

19.1

13.5

38.1

40.6

1.55

769

(3015171) Extractable nuclear Ab [Units/volume] in Serum

2.07

1.07

1.4

1.2

—

1.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.18

1.07

1.7

1.3

—

(3018418) pH of Serum or Plasma

324

1.42

1.06

5.6

3.8

7.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.90

1.06

5.8

8.5

0.5

0.7

0.54

(3017143) Hepatitis C virus Ab [Presence] in Serum

115

1.65

1.06

1.8

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

465

1.38

1.05

3.8

4.2

—

(1761868) Lipid panel - Serum or Plasma

453

0.70

1.04

3.1

2.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.32

1.04

1.2

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

319

1.40

0.99

3.2

2.9

7.5

7.4

mmol/l

0.05

271

(3015377) Calcium [Moles/volume] in Serum or Plasma

357

1.39

0.97

2.2

3.4

2.3

2.4

mmol/l

0.09

322

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.82

0.96

1.0

1.3

—

34.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.82

0.96

3.2

2.1

—

(40761536) Microorganisms panel - Urine sediment

1.67

0.95

3.3

3.4

—

(3013512) EKG study

328

0.68

0.95

4.0

3.5

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

196

1.47

0.93

5.1

3.3

1307.9

119.6

ng/l

0.58

160

(36304419) Bacteria [Presence] in Urine

296

1.39

0.91

3.9

2.5

—

(4010399)

1.66

0.88

1.2

1.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

429

1.34

0.86

3.5

2.3

93.5

130.7

ug/l

1.47

390

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.82

0.86

1.4

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.67

0.84

1.5

1.9

—

(3048689) Calprotectin [Mass/mass] in Stool

114

1.56

0.84

2.7

2.5

68.5

162.9

ug/g

1.23

(3032080) INR in Blood by Coagulation assay

422

1.33

0.83

8.8

8.1

1.1

1.2

inr

0.67

138

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.91

0.83

1.2

5.6

—

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.72

0.81

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

839

1.33

0.81

4.0

3.7

15.0

14.9

pmol/l

0.03

755

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.85

0.80

1.7

2.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.85

0.80

1.8

1.2

0.2

g/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

321

1.35

0.79

3.9

3.8

7.2

10.7

mg/mmol

0.37

202

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.79

0.0

1.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.80

0.77

1.0

1.2

—

(1616796) Gas panel - Central venous blood

2.22

0.77

3.8

3.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

118

1108

1.43

0.75

18.9

12.9

22.8

23.4

mg/l

0.07

854

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.12

0.75

1.4

1.0

—

(3011288) Drugs identified in Urine by Screen method

2.12

0.75

1.0

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.04

0.73

1.2

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.79

0.72

1.7

2.2

0.4

0.9

ug/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

289

1.33

0.71

1.6

1.7

1.5

1.4

mmol/l

0.15

246

(3041096) Erythrocytes [Presence] in Urine by Automated

317

1.32

0.71

3.2

3.1

—

(40768797) Stomach Pathology biopsy report

145

1.44

0.71

1.2

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.65

0.70

2.4

2.3

63.3

59.0

ml/min/173m2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.69

0.70

5.7

8.2

1.3

1.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.88

0.69

1.8

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.88

0.69

1.6

1.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.88

0.69

1.4

1.7

55.6

69.8

pmol/l

—

(3030467) Casts [#/volume] in Urine by Automated count

309

1.32

0.69

3.8

2.5

0.2

0.4

e6/l

1.44

229

(40761511) CBC panel - Blood by Automated count

124

1179

1.48

0.69

15.1

12.5

—

(3044640) Blood type and Crossmatch panel - Blood

328

1.31

0.68

3.0

2.3

—

(3026008) Bacteria identified in Urine by Culture

319

1.31

0.68

4.6

2.6

—

(3018095) Leukocytes [#/volume] in Urine

385

1.29

0.67

5.0

3.0

96.8

115.7

e6/l

0.10

269

(3000494) Fungus identified in Specimen by Culture

138

1.44

0.67

1.4

1.5

—

(3037756) Immunofixation for Serum or Plasma

1.81

0.67

1.0

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

156

1.41

0.66

4.4

2.4

3.1

2.1

e6/l

0.30

(40768443) Skin Pathology biopsy report

1.67

0.63

1.6

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.53

0.63

1.6

2.0

—

(3002582) Erythrocytes [#/volume] in Urine

332

1.29

0.62

3.9

2.7

22.0

163.4

e6/l

1.52

251

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.65

0.56

2.2

2.6

—

(3042936) Bacteria identified in Isolate by Culture

143

1.38

0.56

2.8

2.3

—

(3022621) pH of Urine by Test strip

1.53

0.55

2.3

2.7

—

(4034850)

1.60

0.55

17.3

7.6

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.46

0.53

7.1

3.7

3.5

2.7

mmol/l

—

(3012516) Albumin [Mass/volume] in Urine

301

1.26

0.53

3.3

3.1

69.6

56.9

mg/l

0.14

192

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.52

0.52

2.3

2.2

—

(40761535) Cells panel - Urine sediment

1.49

0.50

4.7

3.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

175

1.31

0.47

4.2

2.2

1.5

1.3

e6/l

0.17

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

383

1.22

0.45

4.0

2.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

412

1.21

0.45

3.4

3.5

45.0

28.5

ng/l

0.31

275

(1761482) Bacteria [#/volume] in Urine by Culture

1.64

0.43

4.0

3.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

671

1.19

0.41

3.0

2.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.41

0.0

1.1

—

(3045414) Leukocytes [Presence] in Urine

1.44

0.39

1.8

1.3

—

(3020891) Body temperature

1.44

0.39

7.8

3.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

115

1103

1.25

0.39

4.9

4.4

6.2

6.0

mmol/l

0.77

109

1007

(3018405) Lactate [Moles/volume] in Arterial blood

1.40

0.38

7.4

5.1

1.3

mmol/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.40

0.38

1.2

1.8

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.33

0.38

7.1

3.5

5.7

5.4

kpa

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.42

0.38

6.3

2.6

109.9

71.1

ng/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.42

0.38

1.6

—

(3000963) Hemoglobin [Mass/volume] in Blood

130

1267

1.40

0.37

27.1

19.2

135.0

137.0

g/l

0.70

130

1244

(3035941) MCH [Entitic mass]

130

1266

1.41

0.37

26.7

19.0

30.2

30.4

0.55

130

1246

(3024731) MCV [Entitic volume]

130

1265

1.43

0.37

26.7

19.1

90.8

91.1

0.34

130

1245

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.37

0.35

1.6

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.29

0.32

4.3

3.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.36

0.32

4.0

20.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

112

1080

1.19

0.30

16.4

11.7

83.7

81.4

ml/min/173m2

0.63

894

(3022313) Gas panel - Capillary blood

1.26

0.30

6.0

3.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.24

0.27

1.0

1.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

123

1.25

0.26

28.9

19.4

—

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.23

0.22

2.0

1.7

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.8

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.0

—

13.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.2

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.9

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.20

0.0

1.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

309

0.88

0.19

4.0

21.3

21.4

0.01

142

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

118

1154

1.15

0.18

4.9

2.7

2.8

mmol/l

0.28

112

1068

(3000492) Spirometry study

111

1.19

0.16

1.3

1.5

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

383

1.10

0.16

4.1

4.4

1.9

2.9

ug/l

0.61

345

(4035726)

107

0.83

0.13

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

123

1.15

0.13

12.6

6.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.09

0.09

1.3

1.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

571

1.06

0.08

4.3

6.5

9.4

11.3

umol/l

1.45

541

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.77

0.08

1.6

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.10

0.08

2.7

26.4

24.9

mmol/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

101

0.88

0.06

2.2

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

111

0.89

0.06

1.4

1.6

—

(3019225) pH of Specimen

100

1.11

0.05

3.3

4.9

—

(3003694) ABO and Rh group [Type] in Blood

292

0.95

0.05

1.1

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

163

1.05

0.01

1.5

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

227

0.96

0.01

3.0

2.7

0.7

0.8

ug/l

0.35

143

(3002256) Pathology report gross observation

137

1.02

0.00

1.1

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

14.0

—

(3036048) Francisella tularensis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

31.7

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3025941) Bacteria identified in Stool by Culture

0.86

0.00

1.0

1.3

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

289.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

15.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.97

0.00

1.0

1.7

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.5

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

0.0

3.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

214.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.3

—

183.1

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

106

1060

1.00

0.00

6.8

5.6

41.2

40.1

mmol/mol

0.48

101

979

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

2.8

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.4

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.8

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.6

—

218.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.8

—

11.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3027923) C peptide [Moles/volume] in Serum or Plasma

0.00

0.0

2.3

—

0.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.0

—

(3017704) Immunofixation for Urine

0.00

0.0

2.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

1.4

—

0.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FIBROBLASTNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FIBROBLASTNAS	1.513 [1.07, 2.14]	0.019
Birth year	0.992 [0.98, 1.0]	0.059

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 333 females with M13_FIBROBLASTNAS died.

Males

Parameter	HR [95% CI]	p-value
M13_FIBROBLASTNAS	1.146 [0.9, 1.45]	0.263
Birth year	0.993 [0.98, 1.0]	0.158

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 384 males with M13_FIBROBLASTNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_FIBROBLASTNAS.

N-year risk	Females	Males
1	0.163%	0.247%
5	0.856%	1.611%
10	2.199%	3.758%
15	3.941%	7.482%
20	6.81%	12.945%

Relationships between endpoints

↥

Index endpoint: M13_FIBROBLASTNAS – Other fibroblastic disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other fibroblastic disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints