Hand

Z21_HAND

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — ZA4.0 Cause of death: ICD-10 — ZA4.0 2 out of 7 registries used, show all original rules.	189
4. Check minimum number of events None	189
5. Include endpoints None	189
6. Filter based on genotype QC (FinnGen only)	189

Control definitions (FinnGen only)

Control exclude: Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z[AB]

NAME	Z21_HAND
CONTROL_EXCLUDE	Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	ZA40
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	ZA40
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hand based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	189	114	75
Unadjusted period prevalence (%)	0.04	0.04	0.03
Median age at first event (years)	54.08	52.12	57.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
168: Matched controls
1679

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

ZA4.0

ICD-10 Finland

Hand

4503599627370496.0

237.5

167

L12

ICPC

Hand/finger symptom/complaint

4.4

11.2

126

Z25.8

ICD-10 Finland

Need for immunization against other specified single viral diseases

4.5

10.4

106

-48

ICPC

Clarification/discussion RFE/demand

8.6

10.3

L11

ICPC

Wrist symptom/complaint

5.8

10.2

SPAT1104

SPAT

Monitoring of emergency patient

6.1

9.9

Z20.9

ICD-10 Finland

Contact with and exposure to unspecified communicable disease

11.0

9.8

-31

ICPC

Medical examin/health eval partial

5.5

9.8

-57

ICPC

Physical medicine/rehabilitation

105.7

9.5

EB1CA

NOMESCO Finland

Tooth X-ray additional picture

4.8

9.3

L81

ICPC

Injury musculoskeletal NOS

17.5

8.7

SDA04

NOMESCO Finland

Very demanding parodonthologic therapy

2.9

7.6

250

-60

ICPC

Result test/procedure

5.6

7.4

G56.0

ICD-10 Finland

Carpal tunnel syndrome

3.5

7.3

117

SPAT1097

SPAT

Recording of ECG

3.4

7.0

115

S04

ICPC

Lump/swelling localized

4.2

7.0

WYA00

NOMESCO Finland

Screening and health check-up

9.3

6.7

Z25.1

ICD-10 Finland

Need for immunization against influenza

5.4

6.6

N02AX02

ATC

tramadol; systemic, rectal

2.4

6.6

459

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.6

6.6

264

ACC51

NOMESCO Finland

Release of median nerve

4.5

6.5

SPAT1254

SPAT

Administration of medicine

3.4

6.2

101

-50

ICPC

Medication/prescr/renewal

5.6

6.2

N02BE01

ATC

paracetamol; systemic, rectal

3.0

6.2

148

1194

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

2.3

6.2

559

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

9.95

15.82

1.2

1.8

—

(3005570) Glucose [Moles/volume] in Urine

8.14

9.39

2.3

1.8

—

(3037121) Protein [Mass/volume] in Urine

4.85

8.59

3.0

3.6

0.59

0.12

g/l

—

(3013512) EKG study

392

2.30

6.72

3.8

3.4

—

(3022313) Gas panel - Capillary blood

3.95

6.38

3.8

2.1

—

(3019225) pH of Specimen

120

2.89

6.09

4.4

3.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

3.43

5.96

3.7

2.1

1.74

1.54

mmol/l

0.14

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

180

1571

4.06

5.77

16.2

11.7

17.55

22.00

mg/l

1.31

158

1230

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.26

5.76

3.6

2.1

5.07

5.15

kpa

0.23

(4024509)

8.52

4.61

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

10.37

4.56

1.1

1.3

1.74

1.66

mmol/l

—

(3048689) Calprotectin [Mass/mass] in Stool

210

2.22

4.46

2.5

286.20

110.52

ug/g

0.71

162

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

147

1182

2.10

4.35

4.5

3.9

15.06

14.52

pmol/l

1.81

142

1087

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

170

1453

2.69

4.29

14.0

10.8

85.35

85.54

ml/min/173m2

0.04

151

1175

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

144

1155

2.04

4.21

7.3

6.8

69.30

76.47

u/l

2.63

139

1082

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

518

1.86

4.08

3.4

3.3

33.02

36.07

ng/l

0.08

318

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

677

1.81

3.91

9.8

6.7

1.22

1.21

mmol/l

0.40

578

(3004588) Protein electrophoresis panel - Serum or Plasma

2.68

3.69

2.0

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

153

2.23

3.67

17.1

17.7

1.37

1.24

inr

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.78

3.59

2.9

2.1

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

113

862

1.77

3.58

4.0

4.7

6.35

6.55

mmol/l

0.47

104

787

(3037522) Nuclear Ab [Titer] in Serum

207

2.05

3.50

1.4

1.5

616.00

567.55

titre

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

103

771

1.74

3.43

4.7

5.7

9.25

10.68

umol/l

1.51

737

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

163

1406

2.16

3.37

5.5

5.1

39.29

39.19

mmol/mol

0.05

158

1331

(3017181) Myelocytes/100 leukocytes in Blood

117

2.31

3.34

5.9

3.9

0.10

0.80

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

553

1.74

3.32

2.2

1.8

103.03

95.71

pmol/l

0.49

267

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.01

3.27

1.8

2.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

170

1497

2.35

3.23

4.7

4.1

5.83

5.86

mmol/l

0.11

164

1394

(3002179) Metamyelocytes/100 leukocytes in Blood

106

2.33

3.18

4.5

3.9

0.22

0.38

—

(36660697) Celiac disease serology panel - Serum

121

2.23

3.10

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

447

1.73

3.07

2.9

2.2

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.88

3.06

1.5

1.4

2.82

3.01

g/l

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

4.44

3.03

1.2

2.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

219

1.92

2.98

3.0

2.6

5.93

2.71

e6/l

1.03

117

(4198724)

6.84

2.89

2.5

1.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

277

1.82

2.88

1.2

1.3

18.99

9.00

u/ml

0.24

109

(3042936) Bacteria identified in Isolate by Culture

192

1.94

2.82

2.7

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

134

1111

1.71

2.81

3.1

3.0

35.31

44.09

u/l

1.42

128

1062

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.72

2.77

1.5

1.4

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.72

2.77

1.5

1.4

7.55

7.76

g/l

—

(3044927) Protein electrophoresis panel - Urine

6.15

2.72

1.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

171

1534

2.20

2.68

4.7

4.1

1.45

1.49

mmol/l

0.52

162

1443

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

171

1541

2.15

2.53

4.8

4.2

4.66

4.72

mmol/l

0.28

165

1456

(3021440) Promyelocytes/100 leukocytes in Blood

110

2.13

2.53

6.5

4.0

0.00

0.11

—

(3023368) Bacteria identified in Blood by Culture

347

1.69

2.50

3.6

3.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.93

2.49

3.0

2.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

166

1483

1.98

2.48

4.6

3.7

1.28

1.26

mmol/l

0.22

158

1391

(3022621) pH of Urine by Test strip

111

2.11

2.47

2.8

2.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

173

1569

2.21

2.46

4.9

4.5

2.80

2.81

mmol/l

0.05

167

1471

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.05

2.45

1.6

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

3.75

2.39

1.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

6.38

2.38

1.8

1.1

4.92

8.44

mmol/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

121

1005

1.57

2.26

4.7

3.9

—

63.77

—

(3025159) Blasts/100 leukocytes in Blood

108

2.06

2.26

6.3

4.0

0.75

0.38

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

349

1.63

2.21

1.2

0.45

1.90

u/ml

1.66

101

(40761511) CBC panel - Blood by Automated count

179

1658

2.50

2.21

17.1

11.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.65

2.14

1.3

—

(42870588) Differential panel, method unspecified - Blood

484

1.56

2.13

7.2

5.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.00

2.10

1.4

1.5

—

(3019150) Specific gravity of Urine by Refractometry

345

1.61

2.09

3.1

3.5

1.02

kg/l

0.08

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

286

1.65

2.07

1.3

11.56

32.51

iu/ml

2.15

(3019309) Folate [Moles/volume] in Red Blood Cells

229

1.71

2.04

1.9

1.7

992.40

1149.88

nmol/l

0.61

179

(3004789) Transferrin [Mass/volume] in Serum or Plasma

185

1.74

1.90

4.0

2.2

2.42

2.41

g/l

0.04

167

(3018095) Leukocytes [#/volume] in Urine

514

1.50

1.88

4.5

3.3

42.19

61.00

e6/l

0.22

357

(3003458) Phosphate [Moles/volume] in Serum or Plasma

162

1.78

1.87

11.1

5.5

1.05

1.04

mmol/l

0.13

154

(3025468) Yersinia sp identified in Specimen by Organism specific culture

3.61

1.85

2.0

1.4

—

(3021788) Differential panel - Synovial fluid

3.61

1.85

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.61

1.85

2.0

1.4

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

117

1.89

1.83

6.1

3.0

72.07

74.04

ng/l

0.04

107

(3045424) Erythrocytes [Presence] in Urine

2.83

1.81

1.3

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

124

1064

1.48

1.77

4.7

4.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.41

1.76

2.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

3.41

1.76

2.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

3.41

1.76

2.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.41

1.76

2.0

1.4

—

(40768797) Stomach Pathology biopsy report

182

1.70

1.73

1.2

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.98

1.71

2.0

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

143

1.78

1.71

1.6

1.7

382.46

379.85

nmol/l

0.03

131

(3032080) INR in Blood by Coagulation assay

535

1.46

1.65

6.9

6.7

1.10

1.16

inr

0.35

161

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.08

1.64

1.7

2.5

37.64

40.55

u/l

0.21

(3020630) Protein [Mass/volume] in Serum or Plasma

101

1.86

1.55

2.4

1.9

67.75

67.63

g/l

0.02

(40768804) Tissue Pathology biopsy report

607

1.42

1.53

2.1

2.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

3.39

1.53

3.0

2.0

—

(3004616) Nuclear Ab [Presence] in Serum

2.78

1.44

1.0

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.47

1.40

1.1

2.0

—

(3029937) Albumin [Presence] in Urine by Test strip

411

1.44

1.40

3.9

3.5

0.00

estimate

—

139

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.99

1.36

1.0

1.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.19

1.36

1.3

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

334

0.61

1.34

2.7

3.5

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

2.10

1.28

1.1

1.4

394.33

268.35

ug/g

—

(3003338) MCHC [Mass/volume]

127

1398

0.72

1.26

17.7

15.2

333.96

333.14

g/l

0.45

127

1393

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.05

1.25

1.8

1.6

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.05

1.25

1.0

—

17.65

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

269

1.47

1.21

1.6

1.8

397.90

466.60

pmol/l

0.48

240

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

152

0.51

1.20

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

154

0.50

1.20

1.6

1.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.35

1.19

3.2

3.94

4.77

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.35

1.19

3.2

3.3

57.50

61.04

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

1.17

0.0

3.9

—

24.33

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.10

1.17

1.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

444

1.37

1.14

3.7

2.9

—

(3045414) Leukocytes [Presence] in Urine

1.87

1.12

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

2.23

1.09

1.0

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

158

0.55

1.04

6.6

6.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

2.31

1.04

1.0

1.3

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.31

1.04

1.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

2.31

1.04

2.2

1.3

—

(3011288) Drugs identified in Urine by Screen method

1.96

1.04

2.9

1.6

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

2.20

0.98

1.2

1.9

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.98

0.0

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

790

1.29

0.97

6.3

5.5

1.94

1.96

e9/l

0.06

712

(3016879) Cocaine [Presence] in Urine

1.76

0.95

2.3

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

467

1.32

0.92

2.3

3.1

2.35

mmol/l

0.07

410

(3005322) IgE [Units/volume] in Serum or Plasma

1.69

0.90

1.4

1.2

127.49

520.35

u/ml

0.66

(3013650) Neutrophils [#/volume] in Blood by Automated count

101

895

1.28

0.89

7.1

8.7

3.80

3.97

e9/l

0.39

793

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.90

0.88

1.3

—

(4010399)

112

1.57

0.88

1.6

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

332

1.34

0.87

1.4

1.3

2.07

2.28

g/l

0.31

207

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

122

1109

1.28

0.86

2.7

3.3

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.97

0.85

6.7

2.0

2.88

3.82

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

501

1.29

0.84

3.9

2.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.74

0.84

1.5

1.4

—

(3000494) Fungus identified in Specimen by Culture

199

1.42

0.84

1.5

—

(3002256) Pathology report gross observation

173

1.44

0.84

1.3

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.65

0.83

1.0

—

(3018418) pH of Serum or Plasma

422

0.74

0.83

10.2

3.4

7.39

7.40

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

201

1.40

0.80

1.6

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.80

0.0

4.0

—

32.94

—

(3028707) Methadone [Presence] in Urine by Screen method

1.84

0.79

4.0

1.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

228

1.38

0.79

2.7

3.4

0.83

0.82

mmol/l

0.14

219

(3027008) Opiates [Presence] in Urine

1.64

0.77

2.4

1.4

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.11

0.75

1.6

1.3

—

(3049717) Cytology report of Urine Cyto stain

1.67

0.74

3.2

2.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

331

1.30

0.74

3.4

2.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.70

0.73

2.7

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.62

0.73

2.4

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.62

0.73

2.7

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.62

0.73

2.6

1.4

—

(40768793) Breast Pathology biopsy report

1.82

0.73

1.0

1.2

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

586

1.25

0.73

5.4

4.5

36.70

36.08

g/l

0.64

553

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.61

0.72

1.2

2.1

—

(40761536) Microorganisms panel - Urine sediment

118

0.58

0.70

8.0

3.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

120

0.57

0.70

1.3

1.5

—

(3022145) Colonoscopy Study observation

171

1.39

0.69

1.5

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

1.81

0.66

1.4

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

129

1.44

0.66

1.5

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

1.74

0.64

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

165

1.38

0.64

2.5

1.5

—

(3019060) Gas panel - Arterial blood

1.53

0.61

2.3

10.9

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

112

0.61

0.60

1.6

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.59

0.0

3.2

—

21.68

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

304

1.27

0.59

1.5

1.4

—

(3003396) Base excess in Arterial blood by calculation

150

1.37

0.58

4.9

10.6

1.16

1.25

mmol/l

0.03

119

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.50

0.58

1.8

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

427

1.23

0.58

4.9

3.8

8.89

11.60

mg/mmol

0.18

271

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

698

1.20

0.56

4.5

4.2

—

(3002582) Erythrocytes [#/volume] in Urine

438

1.23

0.56

3.6

2.7

14.11

194.60

e6/l

0.65

336

(3052851) Hemolysis interference index of Serum or Plasma

1.56

0.53

2.5

3.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

244

0.75

0.51

2.6

2.4

0.48

1.00

e6/l

—

142

(3000991) Gas panel - Venous blood

110

0.62

0.50

28.0

6.8

—

(3025941) Bacteria identified in Stool by Culture

1.43

0.49

1.1

1.2

—

(36304419) Bacteria [Presence] in Urine

391

0.81

0.47

3.2

2.6

—

(40758558) Short blood count panel - Blood

370

1.21

0.46

5.4

6.4

—

(3008898) HLA-B27 [Presence]

1.46

0.46

1.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.58

0.46

1.6

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

759

1.17

0.45

3.6

3.3

0.00

estimate

—

144

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.47

0.45

6.7

14.8

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

122

1.34

0.44

1.1

1.3

69.00

131.23

iu/ml

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

606

1.16

0.41

3.6

3.4

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

0.98

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.41

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.48

0.40

1.2

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

141

1466

0.85

0.39

15.6

12.9

40.55

40.30

0.13

100

1143

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.39

0.0

1.0

—

(3030467) Casts [#/volume] in Urine by Automated count

404

0.84

0.39

3.2

2.7

0.05

0.38

e6/l

2.69

305

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.37

0.39

2.8

3.8

4.51

4.59

pmol/l

0.10

(40768443) Skin Pathology biopsy report

1.36

0.38

1.3

1.2

—

(3000850) Epithelial cells [#/volume] in Urine

298

0.81

0.38

3.1

2.2

2.95

4.72

e6/l

1.41

265

(3003694) ABO and Rh group [Type] in Blood

435

1.17

0.38

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

157

0.75

0.37

1.9

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

222

0.79

0.37

1.2

1.8

—

(3044889) 12 lead EKG panel

110

1038

1.14

0.37

2.9

3.6

—

(3012516) Albumin [Mass/volume] in Urine

398

1.17

0.37

3.8

3.2

110.34

401.76

mg/l

0.66

265

(1761482) Bacteria [#/volume] in Urine by Culture

1.44

0.36

1.2

4.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.39

0.35

2.0

1.3

28.72

22.83

iu/l

—

(21494755) Public health laboratory ask at order entry panel

201

1.22

0.34

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

297

1.18

0.32

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

336

1.16

0.31

2.4

1.6

1.18

0.95

mg/l

0.35

263

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.28

0.30

1.4

1.2

—

(3012544) pH of Venous blood

119

0.74

0.28

15.4

3.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.28

0.28

1.3

1.0

—

(3000492) Spirometry study

159

1.22

0.28

1.3

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.69

0.26

1.2

1.6

—

(3000330) Specific gravity of Urine by Test strip

0.69

0.26

2.8

3.3

—

(3026008) Bacteria identified in Urine by Culture

419

1.13

0.26

2.8

2.6

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.29

0.23

1.4

4.8

3.96

3.90

mmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.24

0.22

1.9

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

1.20

0.21

1.0

1.4

—

49.08

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.4

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

2.6

—

(4211845)

0.00

0.21

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

8.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

0.21

0.0

2.1

—

3.50

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.26

0.20

1.8

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

165

0.84

0.20

9.9

6.3

105.86

104.13

mmol/l

1.11

160

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.20

0.0

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.21

0.20

1.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.24

0.19

1.2

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.16

0.19

1.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

214

1.14

0.18

1.8

1.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.19

0.18

1.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

361

1.10

0.17

1.4

1.5

—

(40761535) Cells panel - Urine sediment

111

1.18

0.16

2.7

3.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

368

0.91

0.16

4.5

4.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

255

1.12

0.16

1.7

2.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.13

0.15

9.8

5.8

23.83

25.01

mmol/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

109

0.82

0.13

1.3

1.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

135

0.88

0.10

1.3

2.0

—

(4094501)

1.14

0.10

1.0

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

184

1.10

0.09

1.4

1.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.10

0.08

2.3

2.2

—

(1761868) Lipid panel - Serum or Plasma

581

1.05

0.08

2.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.03

0.08

1.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

128

1.10

0.07

1.5

2.4

0.24

0.22

g/l

0.87

116

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

132

0.90

0.07

3.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

197

1.07

0.06

1.6

1.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

269

1.05

0.04

4.2

3.4

14.44

248.72

ng/l

1.22

196

(3021589) Normoblasts [#/volume] in Blood

668

1.03

0.03

9.8

8.8

0.00

e9/l

0.51

550

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

349

0.97

0.02

3.4

4.0

22.43

19.92

0.53

144

(3021601) Nitrite [Presence] in Urine by Test strip

758

0.98

0.01

4.4

4.7

0.00

estimate

—

142

(3009261) Glucose [Presence] in Urine by Test strip

768

0.98

0.01

3.6

3.4

0.00

estimate

—

135

(46235355) HIV 1 and 2 tests - Meaningful Use set

377

0.98

0.01

1.7

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

234

0.98

0.00

1.4

2.1

—

(4035726)

118

1.02

0.00

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

262

0.99

0.00

3.3

2.8

0.69

0.70

ug/l

0.03

161

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

115

1.05

0.00

3.1

2.0

63.14

71.02

ml/min/173m2

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

24.35

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.92

0.00

1.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.88

0.00

8.8

2.1

1.12

1.39

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.91

0.00

1.2

1.7

279.67

280.30

mu/l

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.7

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.7

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.7

—

8.29

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

11.24

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.94

0.00

1.6

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.92

0.00

8.8

2.2

0.55

0.69

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.2

—

1949.00

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3013247) Albumin in CSF/Albumin in Serum or Plasma

0.00

-0.00

0.0

1.0

—

6.32

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.6

—

3.36

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

97.80

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3044007) Cell count panel - Peritoneal fluid

0.00

-0.00

0.0

1.2

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_HAND – Hand

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Hand

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Hand (Z21_HAND)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints