info icon

Mantle cell lymphoma

C3_MANTLE_CELL_LYMPHOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C83.1
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 9673
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

288

4. Check minimum number of events

None

288

5. Include endpoints

None

288

6. Filter based on genotype QC (FinnGen only)

288

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 288 61 227
Unadjusted period prevalence (%) 0.08 0.02 0.10
Median age at first event (years) 70.21 68.04 70.79

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
276
Matched controls
2759
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C83.1
ICD-10 Finland
Mantle cell lymphoma
+∞
323.0
275
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
338.4
262.5
248
69
XW000
NOMESCO Finland
Bone marrow biopsy
57.8
133.8
159
63
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
108.8
125.9
132
23
WW500
NOMESCO Finland
Blood transfusion
41.7
104.5
133
60
L03AA02
ATC
filgrastim; parenteral
53.6
102.5
122
40
L03AA13
ATC
pegfilgrastim; parenteral
57.9
95.9
112
32
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
36.5
95.1
125
61
9673/3-C42.1
ICD-O-3
Mantle cell lymphoma of bone marrow
+∞
93.1
84
*
M04AA01
ATC
allopurinol; systemic
16.5
92.9
192
335
JN4BD
NOMESCO Finland
Extensive body CT
15.8
80.2
151
195
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
83.9
79.5
87
15
A03FA01
ATC
metoclopramide; systemic, rectal
11.4
70.8
169
334
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
19.9
70.1
112
91
WW300
NOMESCO Finland
Transfer of autologic stem cells
298.8
69.7
68
*
9673/3-C77.9
ICD-O-3
Mantle cell lymphoma of lymph node, NOS
+∞
57.3
53
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
19.3
55.0
87
64
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
54.9
54.5
64
15
D70.82
ICD-10 Finland
Drug-induced neutropenia
53.8
53.5
63
15
1XC02
NOMESCO Finland
NA
111.3
50.9
54
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.9
48.4
120
218
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
26.2
46.3
65
32
9673/3-C77.8
ICD-O-3
Mantle cell lymphoma of lymph nodes of multiple regions
+∞
46.1
43
*
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
98.9
45.5
49
6
L03AA14
ATC
lipegfilgrastim; parenteral
63.6
45.5
52
10
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
51.1
45.4
54
13
A04AA01
ATC
ondansetron; systemic, rectal
12.3
44.9
87
99
JN6AD
NOMESCO Finland
CT of torso and neck
37.4
44.8
57
19
PJA10
NOMESCO Finland
Exploration of lymph nodes
49.2
41.0
49
12
H02AB06
ATC
prednisolone; systemic
6.2
40.7
212
964
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
20.8
37.9
57
34
ZX120
NOMESCO Finland
Intravenous
8.4
37.7
92
154
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
79.7
37.1
41
6
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
103.0
33.6
36
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
25.4
33.6
47
22
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
43.4
33.5
41
11
R50.9
ICD-10 Finland
Fever, unspecified
6.0
31.8
104
254
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.9
30.8
70
101
JN4AD
NOMESCO Finland
Body CT examination
7.2
29.7
79
145
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
41.1
29.2
36
10
A04AA02
ATC
granisetron; systemic, transdermal
9.0
29.0
65
91
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
87.0
28.4
31
*
J05AB11
ATC
valaciclovir; oral
6.5
28.3
82
168
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
9.3
27.1
59
78
WW402
NOMESCO Finland
Leucoferesis
+∞
26.5
25
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
29.5
25.5
34
13
WW409
NOMESCO Finland
Other aferesis
273.5
25.1
25
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
20.5
24.2
36
20
TGC00
NOMESCO Finland
Bronchial lavation
14.9
23.3
39
30
ZX112
NOMESCO Finland
Subcutaneous
16.3
22.4
36
25
YNB10
NOMESCO Finland
Collection of stem cells for transplant
226.1
20.9
21
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.5
20.4
136
601
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
62.3
20.2
23
*
212
Kela drug reimbursment
Gout
12.0
20.1
37
35
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
20.0
19
*
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
113.1
19.8
21
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.0
19.1
35
33
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
16.7
18.9
30
20
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
9.8
18.6
38
44
ZX108
NOMESCO Finland
Inhalation
24.8
18.1
25
11
390
Kela drug reimbursment
Ibrutinib
45.2
17.5
21
5
A02BC02
ATC
pantoprazole; systemic
3.4
17.5
215
1411
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
17.4
72
209
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
37.6
16.9
21
6
9673/3-C09.9
ICD-O-3
Mantle cell lymphoma of tonsil, NOS
+∞
16.8
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
16.2
174
1013
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
15.9
66
191
1AA09
NOMESCO Finland
NA
+∞
15.8
15
*
J01MA12
ATC
levofloxacin; systemic
3.3
15.8
100
408
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
17.4
15.5
24
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
14.8
119
567
EMA10
NOMESCO Finland
Biopsy of tonsil
+∞
14.7
14
*
L01XE27
ATC
[U] ibrutinib; oral
157.8
14.6
15
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.6
14.1
42
85
L01AA02
ATC
chlorambucil; oral
56.3
14.0
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
7.2
13.9
34
53
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
13.1
79
307
WZC30
NOMESCO Finland
Teaching
3.4
12.5
68
243
C81.1
ICD-10 Finland
Nodular sclerosis classical Hodgkin lymphoma
135.8
12.5
13
*
YNB00
NOMESCO Finland
Excision of bone marrow for transplantation
135.8
12.5
13
*
N02AA05
ATC
oxycodone; systemic
3.2
12.5
76
295
Z51.5
ICD-10 Finland
Palliative care
4.4
12.4
47
124
H02AB07
ATC
prednisone; oral
3.4
12.2
65
227
1512
Kela drug reimbursment
Ibrutinib
31.5
11.8
15
5
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
31.5
11.8
15
5
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
24.1
11.7
16
7
R06AE07
ATC
cetirizine; oral
2.6
11.7
116
604
D70.89
ICD-10 Finland
Neutropenic splenomegaly
14.7
11.1
18
13
D69.5
ICD-10 Finland
Secondary thrombocytopenia
45.2
11.0
13
*
WX110
NOMESCO Finland
Local anesthesy
2.4
10.7
187
1287
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
10.7
49
153
ZXE00
NOMESCO Finland
One hour or less
2.4
10.6
131
757
WF004
NOMESCO Finland
Palliative radiotherapy
7.6
10.5
24
34
B02.9
ICD-10 Finland
Zoster without complication
4.9
10.4
34
77
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
19.7
10.4
15
8
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
11.2
9.9
18
17
EMB10
NOMESCO Finland
Tonsillectomy
10.1
9.9
19
20
H02AB02
ATC
dexamethasone; systemic
3.5
9.9
49
162
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
20.9
9.9
14
7
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
57.0
9.7
11
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.1
9.7
23
35
9673/3-C80.9
ICD-O-3
Mantle cell lymphoma of unknown primary site
+∞
9.4
9
*
C81.3
ICD-10 Finland
Lymphocyte depleted classical Hodgkin lymphoma
+∞
9.4
9
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
9.2
92
470
WW200
NOMESCO Finland
Immunization
6.9
9.2
22
34
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
16.3
9.1
14
9
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.9
9.0
29
65
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
51.6
8.7
10
*
XX3DW
NOMESCO Finland
Time consuming IT work
3.2
8.6
48
172
XX9CD
NOMESCO Finland
Very extensive complementary CT
92.7
8.5
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.0
8.4
33
90
Z52.89
ICD-10 Finland
Donor of other organ or tissue
+∞
8.4
8
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
8.2
38
119
B01AB10
ATC
tinzaparin; parenteral
4.0
8.2
32
87
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
8.9
7.9
16
19
GD1AD
NOMESCO Finland
Thorax CT examination
4.3
7.8
28
70
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
46.3
7.8
9
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
19.0
7.7
11
6
L01EL01
ATC
ibrutinib; oral
25.8
7.6
10
*
1CX01
NOMESCO Finland
NA
+∞
7.3
7
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.7
7.3
51
210
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
30.9
7.2
9
*
J35.1
ICD-10 Finland
Hypertrophy of tonsils
30.9
7.2
9
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
5.2
7.1
21
43
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
8.6
6.9
14
17
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
17.2
6.8
10
6
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.4
6.8
19
37
ED1AA
NOMESCO Finland
Mandipular X-ray examination
23.1
6.7
9
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.3
6.6
19
38
J01MA14
ATC
moxifloxacin; systemic
2.9
6.6
41
158
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
7.7
6.5
14
19
R05
ICD-10 Finland
Cough
2.3
6.5
64
320
A07AA02
ATC
nystatin; oral
3.6
6.5
28
84
B72
ICPC
Hodgkin Lymphoma
71.4
6.4
7
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
71.4
6.4
7
*
D10.4
ICD-10 Finland
Benign neoplasm: Tonsil
71.4
6.4
7
*
A05AA02
ATC
ursodeoxycholic acid; oral
14.7
6.4
10
7
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.8
6.4
41
163
9673/3-C77.0
ICD-O-3
Mantle cell lymphoma of lymph nodes of head, face and neck
+∞
6.3
6
*
9673/3-C77.4
ICD-O-3
Mantle cell lymphoma of lymph nodes of inguinal region or leg
+∞
6.3
6
*
L04.0
ICD-10 Finland
Acute lymphadenitis of face, head and neck
27.3
6.3
8
*
TPJ00
NOMESCO Finland
Biopsy of superficial lymph node
27.3
6.3
8
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
27.3
6.3
8
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
12.9
6.1
10
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_MANTLE_CELL_LYMPHOMA – Mantle cell lymphoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).