Congenital varicose veins

Q17_CONGENITAL_VARICOSE_VEINS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q27.4
  • Cause of death: ICD-10 Q27.4

2 out of 7 registries used, show all original rules.

172

4. Check minimum number of events

None

172

5. Include endpoints

None

172

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 164 116 48
Unadjusted period prevalence (%) 0.04 0.04 0.02
Median age at first event (years) 40.82 39.83 43.19

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
172
Matched controls
1720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q27.4
ICD-10 Finland
Congenital phlebectasia
+∞
248.8
172
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
50.9
115.1
72
24
D18.0
ICD-10 Finland
Haemangioma, any site
58.5
90.6
53
13
Q27.3
ICD-10 Finland
Peripheral arteriovenous malformation
195.1
31.9
32
*
Q27.9
ICD-10 Finland
Congenital malformation of peripheral vascular system, unspecified
+∞
24.6
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
5.0
24.2
106
419
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
+∞
23.5
22
*
Z2221
NOMESCO Finland
Medical doctor
4.6
21.9
94
360
R4110
NOMESCO Finland
Physiotherapy
4.4
20.3
79
278
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.3
18.9
70
236
Q27.88
ICD-10 Finland
Other specified congenital malformation of peripheral vascular system
+∞
16.9
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.7
16.4
89
384
ZXA00
NOMESCO Finland
Right side
4.0
15.5
59
199
D18.1
ICD-10 Finland
Lymphangioma, any site
+∞
14.8
14
*
XX4BW, ,
NOMESCO Finland
163.3
14.7
15
*
Z3226
NOMESCO Finland
Physiotherapist
3.7
13.7
56
197
EP1LT
NOMESCO Finland
Percutaneous sclerotherapy of vascular malformation of head and neck
+∞
12.7
12
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.1
12.0
39
116
ZXE00
NOMESCO Finland
One hour or less
2.9
11.0
95
508
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
10.5
65
288
Q82.50
ICD-10 Finland
Naevus flammeus
116.8
10.5
11
*
QX3KT, ,
NOMESCO Finland
+∞
10.5
10
*
JN5LT
NOMESCO Finland
Sclerotherapy with direct puncture body area
+∞
10.5
10
*
Q87.21
ICD-10 Finland
Klippel-Trénaunay-Weber syndrome
+∞
10.5
10
*
ZXA05
NOMESCO Finland
Left side
3.3
10.3
49
186
R4120
NOMESCO Finland
Occupational therapy
5.1
10.1
23
51
ZXE20
NOMESCO Finland
More than three and less than five hours
3.8
10.1
35
108
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.8
9.9
19
36
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
58.4
9.8
11
*
H02AB07
ATC
prednisone; oral
3.9
9.6
31
91
Z3231
NOMESCO Finland
Registered nurse
2.7
8.7
65
314
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
13.7
8.5
14
11
XX6KT
NOMESCO Finland
Other sclerotherapy
94.5
8.5
9
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
26.4
7.7
10
*
ZXC12
NOMESCO Finland
Pulse colorlaser
+∞
7.3
7
*
QD9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in lower extremities, unspecified
+∞
7.3
7
*
PG1JT
NOMESCO Finland
Very extensive endovascular embolisation of arterio-venous malformation not elsewhere classified
+∞
7.3
7
*
Q82.58
ICD-10 Finland
Congenital non-neoplastic naevus
21.1
7.2
10
5
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
41.7
6.8
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
6.6
38
158
22700
ICD-8 Finland
Haemangioma and lymphangioma, Haemangioma
72.4
6.5
7
*
WX402
NOMESCO Finland
General anaesthesia
2.5
6.3
49
237
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
79
294
4.12
18.50
2.7
2.0
1.12
0.81
mg/l
0.72
60
222
15
9
18.10
10.07
1.1
1.3
8.75
9.44
umol/l
—
15
9
72
356
2.76
9.33
4.5
8.1
—
—
—
0
0
42
158
3.19
8.88
1.5
1.2
—
—
—
0
0
21
33
7.10
8.81
1.2
1.1
3.27
3.06
u/ml
0.05
15
16
106
655
2.61
8.50
7.4
7.6
0.00
0.00
e9/l
0.80
81
531
78
420
2.57
8.31
2.5
2.3
—
—
—
0
0
107
721
2.28
6.32
5.9
6.0
0.52
0.55
e9/l
0.54
91
648
107
722
2.28
6.28
5.9
6.0
0.04
0.04
e9/l
0.12
91
649
108
749
2.19
5.70
6.0
6.5
0.18
0.18
e9/l
0.08
93
681
108
754
2.16
5.54
6.1
5.9
1.91
1.95
e9/l
0.16
93
691
114
836
2.08
4.85
7.1
9.5
3.56
3.94
e9/l
1.53
94
743
98
691
1.97
4.54
6.0
6.1
—
—
—
0
0
25
103
2.67
4.38
1.2
1.5
—
—
—
0
0
19
68
3.02
4.28
4.4
5.7
23.96
23.76
mmol/l
0.13
19
68
37
187
2.25
4.19
3.9
2.7
2.39
2.42
mmol/l
0.75
29
162
71
470
1.87
3.79
3.0
3.4
13.31
24.34
e6/l
0.61
38
313
38
204
2.11
3.69
2.1
2.7
2.69
3.85
e6/l
0.26
19
110
6
7
8.82
3.29
1.0
1.1
—
—
—
0
0
32
168
2.11
3.27
1.8
2.4
—
—
—
0
0
66
452
1.75
3.02
17.3
9.3
1.20
1.13
inr
0.22
14
144
12
37
3.41
3.00
1.2
1.3
—
—
—
0
0
61
410
1.76
2.97
2.0
1.8
96.40
96.19
pmol/l
0.01
29
222
75
543
1.68
2.75
2.5
1.9
—
—
—
0
0
34
195
1.93
2.73
5.1
3.3
151.00
166.20
ng/l
0.04
21
116
30
168
1.95
2.57
3.2
2.3
13.37
13.82
umol/l
0.12
30
159
105
843
1.63
2.47
3.1
3.1
—
—
—
0
0
23
120
2.06
2.39
1.4
1.4
—
—
—
0
0
5
8
6.39
2.38
1.0
1.4
—
—
—
0
0
5
8
6.39
2.38
1.8
1.1
5.37
5.79
mmol/l
—
5
8
158
1440
2.19
2.16
13.4
11.6
22.62
20.59
mg/l
0.30
128
1072
16
77
2.19
2.04
3.4
3.2
59.90
74.38
e9/l
—
6
57
8
27
3.06
1.96
1.0
1.0
—
—
—
0
0
5
11
4.65
1.95
2.0
1.5
—
—
—
0
0
54
387
1.58
1.95
2.5
2.9
14.46
50.20
e6/l
1.33
35
292
25
146
1.83
1.90
1.7
1.5
—
—
—
0
0
0
54
0.00
1.89
0.0
2.0
—
—
—
0
0
74
573
1.51
1.88
6.1
8.3
1.23
1.22
mmol/l
0.38
68
505
8
29
2.84
1.81
1.1
1.0
—
—
—
0
0
21
118
1.89
1.80
4.1
5.2
—
—
—
0
0
162
1509
2.27
1.77
11.2
10.2
—
—
—
0
0
43
300
1.58
1.73
2.0
3.2
—
—
—
0
0
127
1111
1.55
1.72
3.8
4.0
14.57
14.42
pmol/l
0.31
117
1034
27
168
1.72
1.68
1.3
1.3
—
—
—
0
0
39
269
1.58
1.64
4.8
4.2
—
—
—
0
0
5
14
3.64
1.62
4.2
4.4
—
—
—
0
0
60
456
1.48
1.62
1.6
1.6
—
—
—
0
0
7
26
2.76
1.60
1.0
1.0
—
—
—
0
0
23
140
1.74
1.54
1.3
1.5
—
—
—
0
0
35
239
1.58
1.53
1.5
1.6
—
—
—
0
0
7
27
2.66
1.53
2.6
2.1
40.17
39.07
g/l
—
7
27
11
53
2.15
1.42
1.9
2.0
—
—
—
0
0
9
41
2.26
1.39
1.1
1.3
—
—
—
0
0
8
35
2.35
1.28
1.8
2.3
—
—
—
0
0
47
357
1.44
1.25
2.4
2.7
0.13
0.25
e6/l
0.86
29
261
6
26
2.35
1.19
1.2
1.5
—
—
—
0
0
10
50
2.06
1.19
1.0
1.6
177.20
170.18
u/ml
—
5
28
0
35
0.00
1.16
0.0
1.5
—
—
—
0
0
0
36
0.00
1.15
0.0
19.3
—
1.61
—
0
31
17
104
1.70
1.14
9.0
9.0
—
—
—
0
0
19
284
0.63
1.10
2.4
3.0
—
—
—
0
0
47
365
1.40
1.10
2.4
2.6
—
—
—
0
0
22
147
1.57
1.07
1.2
1.5
—
—
—
0
0
21
141
1.56
1.00
1.4
1.4
—
—
—
0
0
9
49
1.88
1.00
2.4
2.0
—
—
—
0
0
48
380
1.37
1.00
1.4
1.5
2.25
2.13
g/l
0.24
28
229
5
23
2.21
0.98
1.0
1.0
—
—
—
0
0
141
1310
1.42
0.98
4.4
4.6
1.54
2.67
mu/l
0.68
136
1237
6
119
0.49
0.98
2.3
2.4
—
—
—
0
0
15
93
1.67
0.97
1.1
1.1
—
8.20
—
0
5
9
51
1.81
0.96
1.0
1.6
—
—
—
0
0
5
104
0.47
0.92
1.0
1.1
—
—
—
0
0
83
721
1.29
0.89
5.2
5.2
5.88
6.30
mmol/l
1.99
77
659
51
415
1.33
0.88
2.9
3.3
2.37
2.35
mmol/l
0.49
46
376
6
30
2.04
0.88
2.3
2.9
—
—
—
0
0
14
88
1.64
0.87
6.2
7.5
25.06
25.03
mmol/l
0.01
14
88
10
57
1.80
0.85
3.2
2.8
280.70
100.71
ng/l
—
10
52
0
24
0.00
0.80
0.0
1.8
—
—
—
0
0
55
459
1.29
0.79
2.3
2.0
—
—
—
0
0
18
124
1.50
0.79
10.6
7.5
103.67
104.24
mmol/l
0.19
18
124
14
91
1.59
0.78
6.5
4.7
117.48
69.15
ng/l
0.96
14
86
0
28
0.00
0.77
0.0
2.1
—
130.53
—
0
19
109
995
1.26
0.73
6.9
7.3
71.31
76.77
u/l
1.10
109
936
31
243
1.34
0.69
2.2
2.3
635.15
573.09
mosm/kgh2o
0.69
26
211
7
42
1.69
0.69
2.1
3.6
8.43
59.26
u/ml
—
7
34
139
1312
1.31
0.67
3.7
3.6
4.83
4.73
mmol/l
0.56
134
1241
5
28
1.81
0.66
1.2
1.7
—
—
—
0
0
32
254
1.32
0.66
2.0
2.3
5.40
7.31
e6/l
0.65
27
231
7
44
1.62
0.66
13.3
11.4
21.86
24.45
mmol/l
—
7
44
140
1325
1.30
0.64
4.0
3.9
3.01
2.85
mmol/l
1.10
134
1248
75
666
1.22
0.62
3.6
4.2
0.00
0.00
estimate
—
7
131
8
51
1.60
0.61
2.4
1.5
—
—
—
0
0
0
20
0.00
0.61
0.0
8.8
—
0.64
—
0
20
0
22
0.00
0.59
0.0
3.5
—
19.75
—
0
22
15
109
1.41
0.53
1.7
1.7
—
—
—
0
0
75
676
1.19
0.51
2.3
3.0
0.00
0.00
estimate
—
7
125
11
76
1.48
0.49
1.5
1.4
—
—
—
0
0
11
76
1.48
0.49
1.5
1.4
—
—
—
0
0
33
277
1.24
0.45
1.3
1.5
—
—
—
0
0
11
78
1.44
0.44
1.5
1.6
—
—
—
0
0
25
204
1.26
0.44
1.2
1.3
—
—
—
0
0
5
31
1.63
0.43
1.2
1.1
—
—
—
0
0
8
58
1.40
0.42
17.6
9.9
0.56
0.68
%
—
8
58
8
58
1.40
0.42
17.6
9.9
1.21
1.50
%
—
8
58
22
268
0.79
0.41
1.3
1.3
5.78
7.97
u/ml
—
6
104
0
17
0.00
0.41
0.0
3.8
—
70.40
—
0
5
5
35
1.44
0.39
1.6
1.7
0.45
0.67
g/l
—
5
30
0
19
0.00
0.39
0.0
24.0
—
1654.11
—
0
19
0
19
0.00
0.39
0.0
13.3
—
922.42
—
0
19
12
90
1.36
0.37
2.6
2.2
8.32
13.08
nmol/l
1.39
12
85
9
71
1.28
0.37
1.1
1.1
—
—
—
0
0
47
420
1.16
0.34
1.5
1.4
1.19
1.34
u/ml
0.08
13
102
6
88
0.67
0.34
1.7
3.3
—
—
—
0
0
41
363
1.17
0.34
1.6
1.8
—
—
—
0
0
6
47
1.29
0.32
1.5
1.5
—
—
—
0
0
7
98
0.70
0.31
1.9
5.6
—
7.43
—
0
6
49
539
0.87
0.31
2.6
2.3
—
—
—
0
0
7
55
1.28
0.30
1.0
1.1
—
—
—
0
0
72
671
1.13
0.29
2.4
3.0
0.00
0.00
estimate
—
7
133
14
116
1.23
0.23
1.9
2.4
0.60
0.69
ug/l
—
5
65
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
0.15
—
0
6
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.32
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
31
343
0.88
0.21
2.5
3.2
0.00
0.00
estimate
—
7
126
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
3.90
—
0
13
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
107.23
—
0
13
6
48
1.26
0.20
1.7
1.3
—
—
—
0
0
6
48
1.26
0.20
1.3
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
3.3
—
50.67
—
0
6
15
130
1.17
0.16
1.3
1.4
—
—
—
0
0
29
265
1.11
0.16
1.2
1.3
7.48
24.06
iu/ml
—
6
82
6
78
0.76
0.16
2.2
6.3
—
—
—
0
0
9
79
1.15
0.15
1.0
1.1
—
—
—
0
0
9
82
1.10
0.15
3.2
2.2
—
—
—
0
0
7
87
0.80
0.15
1.1
1.5
—
—
—
0
0
13
112
1.17
0.15
2.8
1.9
—
—
—
0
0
7
89
0.78
0.15
1.4
1.2
—
—
—
0
0
36
386
0.91
0.14
2.2
2.5
—
—
—
0
0
13
113
1.16
0.13
2.8
1.9
—
—
—
0
0
13
113
1.16
0.13
2.8
1.9
—
—
—
0
0
13
113
1.16
0.13
2.8
1.9
—
—
—
0
0
58
556
1.07
0.11
2.5
2.8
5.94
5.84
ph
—
8
55
11
96
1.16
0.10
3.1
2.0
—
—
—
0
0
37
390
0.93
0.10
2.2
3.1
36.71
37.64
ng/l
0.01
18
201
11
97
1.14
0.09
2.6
2.1
178.20
2878.39
u/l
—
5
35
6
57
1.05
0.08
4.3
2.5
—
—
—
0
0
16
174
0.91
0.08
1.1
1.2
—
—
—
0
0
10
90
1.12
0.05
1.6
1.2
—
—
—
0
0
96
950
1.02
0.02
3.6
3.9
—
—
—
0
0
11
117
0.94
0.02
2.2
2.1
10.45
10.18
g/l
0.11
11
111
27
277
0.97
0.01
2.6
1.8
—
—
—
0
0
18
184
0.98
0.00
2.3
1.9
—
—
—
0
0
35
349
1.00
0.00
2.7
2.4
—
—
—
0
0
128
1283
0.99
0.00
3.3
3.5
5.62
5.67
mmol/l
0.20
122
1206
11
108
1.02
0.00
3.1
1.9
—
—
—
0
0
10
98
1.02
0.00
1.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
1.19
—
0
8
0
8
0.00
0.00
0.0
6.6
—
7.61
—
0
8
0
8
0.00
0.00
0.0
2.0
—
0.12
—
0
8
0
8
0.00
0.00
0.0
1.0
—
149.96
—
0
8
0
8
0.00
0.00
0.0
1.7
—
163.44
—
0
8
0
8
0.00
0.00
0.0
9.0
—
—
—
0
0
0
8
0.00
0.00
0.0
10.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
7.90
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
453.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
8.00
—
0
5
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
1809.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
0.03
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
38600.00
—
0
7
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
138.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1984.00
—
0
5
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
99
0.90
-0.00
2.3
1.8
1.86
1.39
g/l
—
9
93
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_CONGENITAL_VARICOSE_VEINS – Congenital varicose veins

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).