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Other congenital malformations of brain

DOID Endpoint Browser PheWeb

Q17_OTHER_CONGEN_MALFO_BRAIN

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q04
  • Cause of death: ICD-10 — Q04

2 out of 7 registries used, show all original rules.

188

4. Check minimum number of events

None

188

5. Include endpoints

None

188

6. Filter based on genotype QC (FinnGen only)

177

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_NERVOUS_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q0
Name in latin
Aliae malformationes congenitae encephali

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2987 1324 1657
Only index persons 2131 981 1150
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 5.21 6.59 3.95
Only index persons 9.59 12.95 6.73

-FinnGen-

Key figures

All Female Male
Number of individuals 177 99 78
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 30.74 31.62 29.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
188
Matched controls
1880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q04.8
ICD-10 Finland
Other specified congenital malformations of brain
+∞
95.1
83
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
21.9
88.3
78
59
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
30.6
71.1
50
22
N03AX14
ATC
levetiracetam; systemic
29.0
67.1
48
22
N03AF02
ATC
oxcarbazepine; oral
21.2
64.9
54
35
Q04.6
ICD-10 Finland
Congenital cerebral cysts
+∞
59.6
54
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
22.9
59.6
47
27
N03AG01
ATC
valproic acid; systemic, rectal
10.4
36.3
46
57
183
Kela drug reimbursment
Lamotrigin and topiramate
41.4
30.0
37
11
N03AX11
ATC
topiramate; oral
13.5
29.9
30
26
N03AX09
ATC
lamotrigine; oral
10.8
29.6
35
39
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.3
29.2
51
91
N05BA09
ATC
clobazam; oral
35.0
28.9
37
13
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
32.7
26.9
35
13
G93.0
ICD-10 Finland
Cerebral cysts
156.6
26.4
27
*
XA800
NOMESCO Finland
Neuropsychological investigation
7.2
24.8
42
72
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
29.5
22.6
30
12
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.0
22.1
27
31
N03AX18
ATC
lacosamide; systemic
54.6
20.7
24
5
Q04.9
ICD-10 Finland
Congenital malformation of brain, unspecified
+∞
20.2
19
*
AA1AD
NOMESCO Finland
CT of head and brain
4.5
19.5
62
185
N05BA01
ATC
diazepam; systemic, rectal
5.4
19.3
45
104
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.5
18.7
34
62
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
47.0
17.7
21
5
Q04.3
ICD-10 Finland
Other reduction deformities of brain
+∞
16.9
16
*
N05CD08
ATC
midazolam; nasal, systemic
13.5
16.7
29
25
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.4
15.9
35
76
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.0
15.7
39
94
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
17.0
15.4
24
16
Q04.00
ICD-10 Finland
Agenesis of corpus callosum
+∞
14.8
14
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
21.3
14.6
21
11
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
28.2
13.6
18
7
N03AX22
ATC
perampanel; oral
43.5
13.4
16
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
34.7
12.8
16
5
G40.10
ICD-10 Finland
Simple partial seizures
75.1
12.8
14
*
AAJ20
NOMESCO Finland
Excision of epileptic focus
+∞
12.6
12
*
R62.0
ICD-10 Finland
Delayed milestone
6.1
12.5
23
42
N88
ICPC
Epilepsy
40.5
12.4
15
*
N03AX15
ATC
zonisamide; oral
37.6
11.4
14
*
N03AX23
ATC
brivaracetam; systemic
34.7
10.5
13
*
Z2445
NOMESCO Finland
Psychologist
4.0
10.1
32
92
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
21.5
10.0
14
7
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.7
9.7
34
105
F83
ICD-10 Finland
Mixed specific developmental disorders
8.3
9.7
21
28
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
9.6
77
385
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.5
9.6
37
122
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
105.1
9.5
10
*
Q04.08
ICD-10 Finland
Congenital malformations of corpus callosum
+∞
9.4
9
*
Z2446
NOMESCO Finland
Social worker
3.3
9.2
39
137
H47.2
ICD-10 Finland
Optic atrophy
38.7
9.1
11
*
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
38.7
9.1
11
*
G40
ICD-10 Finland
Epilepsy
19.8
9.1
13
7
F82
ICD-10 Finland
Specific developmental disorder of motor function
9.4
9.0
18
21
N03AG04
ATC
vigabatrin; oral
25.5
9.0
12
5
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
52.5
8.8
10
*
181
Kela drug reimbursment
Retigabine and vigabatrin
52.5
8.8
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
8.4
59
273
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
8.4
50
213
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.9
8.3
26
74
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
8.3
41
157
R1260
NOMESCO Finland
Evaluation of communicative skills
12.5
8.2
14
12
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
18.2
8.2
12
7
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.3
8.0
33
113
P85
ICPC
Mental retardation
11.5
7.9
14
13
G91.1
ICD-10 Finland
Obstructive hydrocephalus
47.0
7.8
9
*
N03AF01
ATC
carbamazepine; oral, rectal
6.7
7.8
19
31
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.7
7.7
17
24
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
7.6
79
438
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
7.5
36
135
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
83.2
7.5
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.4
41
167
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
+∞
7.3
7
*
N03AF03
ATC
rufinamide; oral
+∞
7.3
7
*
Z31.5
ICD-10 Finland
Genetic counselling
3.6
7.3
26
81
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
7.3
62
313
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.9
6.8
21
59
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
41.6
6.8
8
*
G40.89
ICD-10 Finland
Other epilepsy
41.6
6.8
8
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
41.6
6.8
8
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
72.2
6.5
7
*
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
72.2
6.5
7
*
Z3226
NOMESCO Finland
Physiotherapist
2.5
6.5
51
247
N03AF04
ATC
eslicarbazepine; oral
+∞
6.3
6
*
AAF40
NOMESCO Finland
Shunt of cyst of brain to peritoneum
+∞
6.3
6
*
Q04.4
ICD-10 Finland
Septo-optic dysplasia
+∞
6.3
6
*
199
Kela drug reimbursment
Rufinamide
+∞
6.3
6
*
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
27.7
6.3
8
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.4
6.2
16
39
A28
ICPC
Limited function/disability NOS
3.1
6.2
28
101
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
13.1
6.2
10
8
RS222, ,
NOMESCO Finland
10.5
6.1
11
11
H50.0
ICD-10 Finland
Convergent concomitant strabismus
10.5
6.1
11
11
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
6.1
47
225
R4110
NOMESCO Finland
Physiotherapy
2.3
6.1
61
328
Z3231
NOMESCO Finland
Registered nurse
2.2
6.0
67
375
ZXD05
NOMESCO Finland
Urgent procedure
2.3
6.0
61
329

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
500
2.33
7.35
5.2
6.7
37.62
36.81
g/l
0.75
81
480
104
662
2.28
7.09
11.9
10.8
1.22
1.22
mmol/l
0.13
94
594
9
5
18.80
6.32
2.8
2.8
23.44
16.36
umol/l
—
9
5
173
1442
3.50
5.69
19.0
13.1
138.94
139.60
mmol/l
1.86
167
1399
67
387
2.14
5.50
1.5
1.7
104.86
95.73
pmol/l
0.67
37
199
172
1445
3.24
5.25
17.6
13.1
3.98
3.95
mmol/l
0.39
165
1397
8
7
11.86
4.83
3.9
3.3
20.38
22.56
umol/l
—
8
7
27
115
2.57
4.40
1.3
1.5
1176.70
1103.77
nmol/l
0.16
19
92
175
1524
3.14
4.21
10.7
9.0
27.14
26.73
u/l
0.10
170
1480
24
101
2.58
4.01
3.0
4.9
56.58
70.98
e9/l
1.63
13
74
69
449
1.85
3.80
5.2
8.0
—
—
—
0
0
7
8
9.03
3.80
2.1
4.8
—
—
—
0
0
38
203
2.09
3.70
6.6
11.3
1.09
1.02
mmol/l
0.05
33
151
64
411
1.84
3.66
2.3
3.1
2.36
2.38
mmol/l
0.31
57
368
37
197
2.09
3.63
7.8
12.0
—
—
—
0
0
10
21
4.97
3.61
2.8
1.9
12.29
15.99
umol/l
—
10
21
15
52
3.05
3.55
1.5
4.6
2.70
2.36
e6/l
—
10
36
15
52
3.05
3.55
1.4
4.3
397.73
430.62
mg/l
0.12
15
52
26
122
2.31
3.45
4.0
15.1
1.70
1.41
mmol/l
0.47
26
117
14
48
3.07
3.38
1.5
4.9
—
—
—
0
0
42
241
1.96
3.35
1.7
1.4
24.22
21.99
nmol/l
0.33
37
209
53
330
1.84
3.30
4.8
3.5
7.39
7.40
ph
0.48
11
49
101
758
1.72
3.30
8.5
9.8
0.01
0.00
e9/l
0.49
79
589
6
7
8.80
3.28
1.3
1.1
—
—
—
0
0
7
11
6.56
3.21
3.7
2.4
1.08
1.12
umol/l
—
7
11
108
831
1.70
3.17
7.6
7.4
0.04
0.04
e9/l
0.40
91
713
108
831
1.70
3.17
7.6
7.4
0.57
0.56
e9/l
0.14
91
712
117
927
1.69
3.02
8.4
10.6
3.80
3.74
e9/l
0.12
101
788
110
858
1.68
3.01
7.5
7.4
2.24
2.15
e9/l
0.28
93
758
27
139
2.10
2.88
7.0
13.0
104.96
104.27
mmol/l
0.23
27
139
31
169
2.00
2.84
2.1
2.7
2.41
2.43
mmol/l
0.73
25
148
109
859
1.64
2.78
7.9
8.0
0.17
0.20
e9/l
1.69
94
745
20
93
2.29
2.72
2.2
2.0
16.21
19.11
iu/l
0.14
12
72
15
61
2.59
2.69
8.8
16.0
93.63
93.56
%
0.01
15
61
45
284
1.77
2.64
3.3
4.5
—
—
—
0
0
100
780
1.60
2.59
9.4
8.0
—
—
—
0
0
61
424
1.65
2.52
2.5
2.6
—
—
—
0
0
12
45
2.78
2.50
8.8
7.8
—
—
—
0
0
18
86
2.21
2.31
2.2
2.1
7.86
7.89
u/l
—
10
64
6
13
4.73
2.29
2.0
1.2
—
—
—
0
0
21
109
2.04
2.21
8.4
15.5
5.37
5.20
kpa
0.23
21
103
21
109
2.04
2.21
8.3
15.5
13.91
13.37
kpa
0.16
21
104
7
19
3.78
2.17
1.4
3.1
—
—
—
0
0
132
1126
1.58
2.14
3.8
3.7
14.42
14.41
pmol/l
0.01
121
1043
29
172
1.81
2.08
1.4
1.5
540.55
439.84
pmol/l
0.64
22
151
117
976
1.53
2.06
7.2
6.4
95.62
97.11
u/l
0.08
109
915
173
1591
2.09
2.06
14.4
9.2
—
—
—
0
0
29
174
1.79
2.01
1.8
1.6
—
—
—
0
0
33
206
1.73
2.00
17.8
15.3
23.46
24.76
mmol/l
2.23
33
206
7
21
3.42
1.98
2.7
5.3
—
—
—
0
0
18
322
0.51
1.98
1.8
1.8
—
—
—
0
0
8
27
3.05
1.96
1.6
5.8
—
—
—
0
0
5
11
4.64
1.95
1.2
1.6
1.72
1.54
mmol/l
—
5
11
6
17
3.61
1.85
1.5
3.2
—
—
—
0
0
50
355
1.56
1.84
4.2
2.5
—
—
—
0
0
24
141
1.80
1.78
3.5
4.0
0.22
0.21
g/l
0.21
24
133
15
76
2.06
1.69
1.1
1.1
—
—
—
0
0
5
14
3.64
1.62
1.0
1.0
301.80
337.43
mg/l
—
5
14
6
20
3.06
1.59
6.2
2.2
289.67
289.77
mosm/kgh2o
—
6
13
18
101
1.86
1.55
1.1
1.4
—
—
—
0
0
46
334
1.50
1.52
3.7
3.3
—
—
—
0
0
147
1325
1.50
1.49
4.2
4.2
1.76
2.79
mu/l
0.61
132
1240
9
38
2.44
1.48
1.4
5.3
—
—
—
0
0
16
88
1.89
1.46
4.0
5.4
0.38
0.48
%
—
8
25
10
46
2.24
1.42
2.1
3.0
—
—
—
0
0
12
60
2.07
1.41
1.2
15.0
0.90
0.66
%
1.72
12
60
60
467
1.42
1.38
13.9
7.9
1.15
1.17
inr
0.10
19
131
16
90
1.85
1.38
4.2
5.8
0.00
0.22
%
—
8
23
96
810
1.38
1.37
3.0
2.8
—
—
—
0
0
6
24
2.55
1.31
1.2
1.0
—
—
—
0
0
46
344
1.45
1.31
5.3
3.3
0.00
0.01
estimate
0.50
14
123
17
101
1.75
1.24
4.1
5.4
0.44
0.71
%
—
9
34
82
683
1.36
1.23
4.4
3.1
0.00
0.00
estimate
-0.00
15
127
5
19
2.67
1.22
1.8
1.7
—
—
—
0
0
133
1195
1.39
1.22
4.2
3.4
5.57
5.69
mmol/l
0.64
120
1106
42
313
1.44
1.21
3.6
2.9
1.01
1.02
kg/l
—
10
45
28
192
1.54
1.20
1.3
1.5
470.00
370.53
titre
—
8
38
49
378
1.40
1.17
4.2
2.7
17.40
44.14
ng/l
0.98
34
192
164
1534
1.54
1.17
15.0
11.2
26.67
22.36
mg/l
0.75
131
1112
81
683
1.33
1.10
6.0
4.5
0.00
0.00
estimate
-0.00
14
125
5
21
2.42
1.09
4.0
4.3
17.00
8.29
%
—
5
21
10
52
1.97
1.08
2.1
1.6
—
—
—
0
0
15
90
1.72
1.07
4.3
5.7
0.00
0.09
%
—
7
23
25
172
1.52
1.07
14.7
9.2
—
—
—
0
0
25
172
1.52
1.07
3.5
2.7
2.46
2.52
g/l
0.22
25
159
14
83
1.74
1.04
2.9
3.3
—
—
—
0
0
7
34
2.10
1.04
1.1
2.6
—
—
—
0
0
181
1749
1.94
1.03
23.2
17.0
39.84
40.34
%
0.90
175
1673
81
690
1.31
1.00
4.6
3.2
0.00
0.00
estimate
-0.00
15
119
34
254
1.41
0.98
3.6
2.9
—
—
—
0
0
7
37
1.93
0.95
7.0
6.4
—
—
—
0
0
12
193
0.60
0.93
1.5
1.3
—
—
—
0
0
6
28
2.18
0.92
1.7
1.1
—
—
—
0
0
181
1754
1.86
0.92
23.5
16.5
6.64
6.70
e9/l
0.16
176
1693
181
1752
1.89
0.92
23.4
16.4
4.50
4.58
e12/l
1.20
175
1693
10
56
1.83
0.89
5.8
23.1
—
—
—
0
0
15
97
1.59
0.84
2.2
2.3
—
19.62
—
0
5
6
33
1.84
0.80
1.0
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
32
247
1.36
0.77
4.9
3.3
0.79
2.04
e6/l
1.13
13
138
56
469
1.28
0.76
2.0
1.9
—
—
—
0
0
9
55
1.67
0.74
12.1
12.9
—
—
—
0
0
9
56
1.64
0.73
1.6
1.7
—
—
—
0
0
5
25
2.03
0.73
11.4
4.6
—
—
—
0
0
5
28
1.81
0.66
4.2
3.6
43.86
36.31
%
—
5
28
8
55
1.47
0.57
1.5
1.7
—
—
—
0
0
59
514
1.22
0.56
7.3
4.2
135.09
43.33
e6/l
0.71
40
350
55
479
1.21
0.53
1.4
1.6
—
—
—
0
0
6
40
1.52
0.52
1.0
1.1
—
58.84
—
0
10
10
67
1.52
0.51
1.4
1.1
—
—
—
0
0
32
264
1.26
0.50
2.5
2.4
275.33
74.27
ug/g
1.20
24
212
7
46
1.54
0.49
1.1
1.5
—
—
—
0
0
51
445
1.20
0.48
6.2
3.5
37.62
34.58
e6/l
0.05
39
340
27
328
0.79
0.48
1.4
1.7
—
—
—
0
0
47
407
1.21
0.48
5.9
3.5
0.31
0.37
e6/l
0.16
36
302
152
1458
1.22
0.46
19.0
14.7
334.71
334.67
g/l
0.02
152
1450
43
371
1.21
0.45
4.5
2.6
—
—
—
0
0
30
249
1.24
0.45
2.9
3.7
2.81
8.93
mg/mmol
1.83
19
165
8
56
1.45
0.43
2.8
2.1
—
—
—
0
0
56
498
1.18
0.43
1.2
1.5
1.17
1.09
u/ml
0.04
18
108
0
15
0.00
0.41
0.0
1.1
—
203.46
—
0
15
12
88
1.39
0.41
1.7
2.1
—
—
—
0
0
13
97
1.37
0.40
2.8
3.4
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
129
1227
1.16
0.40
3.9
3.7
1.41
1.45
mmol/l
0.47
122
1155
5
35
1.44
0.39
1.0
1.3
—
—
—
0
0
11
147
0.73
0.39
1.3
1.2
—
—
—
0
0
130
1239
1.16
0.38
4.1
3.8
4.56
4.67
mmol/l
0.57
123
1175
14
107
1.33
0.38
7.9
3.4
—
—
—
0
0
43
486
0.85
0.38
2.4
2.3
—
—
—
0
0
26
218
1.22
0.37
1.2
1.2
21.43
26.81
iu/ml
—
9
64
130
1243
1.15
0.35
4.2
3.9
2.77
2.81
mmol/l
0.22
122
1174
20
164
1.25
0.34
2.7
2.4
—
—
—
0
0
125
1195
1.14
0.32
3.7
3.5
1.20
1.27
mmol/l
0.53
117
1129
25
212
1.21
0.32
1.8
1.5
—
—
—
0
0
51
462
1.14
0.31
1.7
1.5
1.83
1.97
g/l
0.30
27
266
7
54
1.31
0.31
2.1
1.9
—
—
—
0
0
7
54
1.31
0.31
3.7
2.4
—
—
—
0
0
36
405
0.86
0.30
2.8
1.9
—
—
—
0
0
7
57
1.24
0.29
1.4
1.9
—
—
—
0
0
9
119
0.74
0.28
1.3
1.4
—
—
—
0
0
10
128
0.77
0.28
1.7
1.7
—
—
—
0
0
10
77
1.32
0.26
1.2
1.2
—
—
—
0
0
101
966
1.10
0.23
5.8
3.8
—
—
—
0
0
45
413
1.12
0.22
6.0
3.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
212.44
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
8.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
37900.00
—
0
10
0
10
0.00
0.21
0.0
21.3
—
0.59
—
0
10
13
154
0.83
0.20
1.5
1.8
—
—
—
0
0
10
122
0.81
0.19
1.8
1.7
—
—
—
0
0
27
242
1.14
0.19
2.7
3.2
27.97
609.30
mg/l
0.96
18
165
22
248
0.87
0.19
2.0
1.7
—
—
—
0
0
114
1105
1.08
0.17
4.8
4.1
35.59
37.86
mmol/mol
3.01
105
1042
5
67
0.74
0.17
1.2
1.1
—
—
—
0
0
12
141
0.84
0.17
1.5
1.4
—
—
—
0
0
14
120
1.18
0.17
1.1
1.2
—
—
—
0
0
13
112
1.17
0.15
1.3
1.4
—
—
—
0
0
12
139
0.85
0.14
1.3
1.9
—
—
—
0
0
10
118
0.84
0.14
1.9
1.7
—
—
—
0
0
16
142
1.14
0.13
1.8
2.3
0.49
0.61
ug/l
0.75
11
76
10
85
1.19
0.12
1.3
1.4
—
—
—
0
0
13
114
1.15
0.12
1.0
1.5
—
—
—
0
0
21
192
1.11
0.11
2.1
3.1
28.69
433.79
ng/l
2.21
13
125
5
47
1.07
0.09
3.2
4.6
4.82
15.03
umol/l
—
5
39
6
55
1.09
0.09
1.2
1.1
—
—
—
0
0
29
274
1.07
0.08
2.3
3.7
0.66
1.24
mg/l
0.98
23
220
7
83
0.84
0.07
3.1
2.0
—
—
—
0
0
12
129
0.93
0.03
1.7
1.7
—
—
—
0
0
12
128
0.93
0.02
1.7
1.7
—
—
—
0
0
10
106
0.94
0.01
1.8
1.8
—
—
—
0
0
12
126
0.95
0.00
1.7
1.7
—
—
—
0
0
19
186
1.02
0.00
1.1
1.2
—
—
—
0
0
21
211
0.99
0.00
1.3
1.2
4.17
7.82
u/ml
0.45
12
85
0
8
0.00
0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
-0.00
1.3
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.51
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
13.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1857.50
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
2.66
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
29.00
—
0
5
0
5
0.00
-0.00
0.0
15.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
45.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_OTHER_CONGEN_MALFO_BRAIN and mortality.

Females

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_BRAIN 4.599 [3.29, 6.44] < 0.001
Birth year 0.992 [0.98, 1.0] 0.067

During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 1102 females with Q17_OTHER_CONGEN_MALFO_BRAIN died.

Males

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_BRAIN 3.755 [2.72, 5.18] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 1405 males with Q17_OTHER_CONGEN_MALFO_BRAIN died.

Mortality risk

Mortality risk for people of age

years, who have Q17_OTHER_CONGEN_MALFO_BRAIN.

N-year risk Females Males
1 0.47% 0.765%
5 2.279% 4.579%
10 5.364% 10.956%
15 10.385% 19.83%
20 18.528% 32.143%

Relationships between endpoints

↥

Index endpoint: Q17_OTHER_CONGEN_MALFO_BRAIN – Other congenital malformations of brain

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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