No definition available.
Congenital malformations of the nervous system
DOID EFO Endpoint Browser PheWeb
Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
796 |
4. Check minimum number of eventsNone |
796 |
5. Include endpoints |
863 |
6. Filter based on genotype QC (FinnGen only) |
863 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q
- Name in latin
- Malformationes congenitae systematis nervosi
Similar endpoints
↥List of similar endpoints to
Congenital malformations of the nervous system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10956 | 5699 | 5233 |
| Only index persons | 8283 | 4517 | 3766 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.16 | 0.15 |
| Only index persons | 0.16 | 0.17 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 10.11 | 14.17 | 5.54 |
| Only index persons | 14.66 | 19.57 | 8.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 863 | 580 | 283 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.12 |
| Median age at first event (years) | 28.62 | 30.37 | 25.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 765
- Matched controls
- 7647
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
+∞
323.0
293
*
ABE50
NOMESCO Finland
Occipitocervical decompression
+∞
99.1
93
*
Q04.8
ICD-10 Finland
Other specified congenital malformations of brain
+∞
72.0
68
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
112.2
57.7
62
6
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.0
56.4
137
204
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.2
53.3
158
310
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.8
49.8
155
321
Q04.6
ICD-10 Finland
Congenital cerebral cysts
+∞
49.5
47
*
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
133.5
47.4
50
*
AA1AD
NOMESCO Finland
CT of head and brain
4.2
46.0
206
623
R51.80
ICD-10 Finland
Headache
3.8
45.2
230
778
G91.1
ICD-10 Finland
Obstructive hydrocephalus
50.5
43.5
52
11
N03AF02
ATC
oxcarbazepine; oral
9.6
41.7
88
102
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.3
40.5
78
76
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
8.6
39.9
90
117
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
36.8
35
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
36.8
35
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.5
35.4
80
104
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
37.8
34.1
43
12
N03AX14
ATC
levetiracetam; systemic
9.0
34.0
74
90
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
31.5
30
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
30.4
29
*
183
Kela drug reimbursment
Lamotrigin and topiramate
13.5
30.3
53
42
G91.0
ICD-10 Finland
Communicating hydrocephalus
43.1
30.2
37
9
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
28.3
27
*
Q05.7
ICD-10 Finland
Lumbar spina bifida without hydrocephalus
+∞
28.3
27
*
Q07.8
ICD-10 Finland
Other specified congenital malformations of nervous system
+∞
28.3
27
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.7
28.3
49
38
2133
FHL
Suntin revisio
280.3
26.9
27
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
30.5
26.5
35
12
7410D
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG LUMBALIS]
+∞
26.2
25
*
Q05.9
ICD-10 Finland
Spina bifida, unspecified
+∞
26.2
25
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
75.0
25.9
29
*
N05BA09
ATC
clobazam; oral
12.5
25.5
46
39
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.7
25.5
44
34
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
25.1
24
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.6
24.2
116
357
N03AX11
ATC
topiramate; oral
6.8
23.7
61
96
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
55.8
23.2
27
5
Q02
ICD-10 Finland
Microcephaly
+∞
23.0
22
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
22.7
100
285
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.7
22.5
40
33
XA800
NOMESCO Finland
Neuropsychological investigation
4.4
22.1
84
209
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
21.8
191
876
G93.0
ICD-10 Finland
Cerebral cysts
23.0
21.8
31
14
N03AX12
ATC
gabapentin; oral
3.2
21.7
125
439
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
21.7
152
611
H47.2
ICD-10 Finland
Optic atrophy
32.2
21.6
28
9
XKC03
NOMESCO Finland
Water cystometry
8.3
21.0
47
60
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
79.0
20.8
23
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
113.1
20.7
22
*
Q06.8
ICD-10 Finland
Other specified congenital malformations of spinal cord
+∞
19.9
19
*
N03AX18
ATC
lacosamide; systemic
16.9
19.8
31
19
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
19.7
207
1038
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
11.0
19.6
37
35
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.0
19.5
81
219
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
15.3
19.0
31
21
Q04.9
ICD-10 Finland
Congenital malformation of brain, unspecified
+∞
18.8
18
*
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
28.6
18.8
25
9
N03AG01
ATC
valproic acid; systemic, rectal
3.8
18.8
82
232
R42
ICD-10 Finland
Dizziness and giddiness
2.6
18.5
154
681
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
18.1
87
266
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
14.1
17.9
30
22
N05BA01
ATC
diazepam; systemic, rectal
2.9
17.7
113
425
2132
FHL
Ventricular operators sunt
184.0
17.6
18
*
N03AF01
ATC
carbamazepine; oral, rectal
5.6
17.6
52
99
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
17.0
233
1308
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
13.8
16.6
28
21
XKD06
NOMESCO Finland
Physiologic investigation of micturition
8.3
16.4
36
45
R20.2
ICD-10 Finland
Paraesthesia of skin
3.7
16.4
74
215
N03AX16
ATC
pregabalin; oral
2.4
16.4
156
737
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
7.7
16.1
37
50
AA1AA
NOMESCO Finland
Head X-ray examination
13.9
16.1
27
20
G04BD04
ATC
oxybutynin; oral, transdermal
5.1
16.0
51
106
Q04.3
ICD-10 Finland
Other reduction deformities of brain
+∞
15.7
15
*
TAB00
NOMESCO Finland
Lumbar puncture
4.6
15.6
55
127
G91.8
ICD-10 Finland
Other hydrocephalus
86.9
15.6
17
*
F83
ICD-10 Finland
Mixed specific developmental disorders
6.0
15.0
41
71
UKC02
NOMESCO Finland
Cystoscopy
3.0
15.0
90
324
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
57.8
14.8
17
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
14.7
76
247
Q07.9
ICD-10 Finland
Congenital malformation of nervous system, unspecified
+∞
14.6
14
*
N03AX09
ATC
lamotrigine; oral
3.4
14.6
73
231
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.5
14.5
52
123
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.9
14.4
47
101
G44.2
ICD-10 Finland
Tension-type headache
2.4
14.3
129
588
N05CD08
ATC
midazolam; nasal, systemic
5.6
13.8
40
75
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.6
13.7
63
186
G40.10
ICD-10 Finland
Simple partial seizures
15.1
13.6
22
15
R4110
NOMESCO Finland
Physiotherapy
2.0
13.6
203
1163
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
8.6
13.6
29
35
Q05.0
ICD-10 Finland
Cervical spina bifida with hydrocephalus
+∞
13.6
13
*
7419D
ICD-9 Finland
Spina bifida, Without mention of hydrocephalus[SPINA BIFIDA APERTA SINE HYDROCEPHALO REG LUMBALIS]
+∞
13.6
13
*
Q04.00
ICD-10 Finland
Agenesis of corpus callosum
+∞
13.6
13
*
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
142.4
13.5
14
*
M03BX01
ATC
baclofen; systemic
7.2
13.5
32
46
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
13.3
108
466
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
13.3
80
288
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.8
13.0
84
318
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
23.0
12.9
18
8
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
50.9
12.9
15
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
11.8
12.9
23
20
R4120
NOMESCO Finland
Occupational therapy
3.1
12.7
71
242
N03AX15
ATC
zonisamide; oral
15.7
12.7
20
13
Q05.8
ICD-10 Finland
Sacral spina bifida without hydrocephalus
+∞
12.5
12
*
Q01.8
ICD-10 Finland
Encephalocele of other sites
+∞
12.5
12
*
N03AX22
ATC
perampanel; oral
20.4
12.5
18
9
N02AX02
ATC
tramadol; systemic, rectal
1.9
12.4
234
1456
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.6
12.2
92
378
R62.0
ICD-10 Finland
Delayed milestone
4.8
12.2
40
87
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
18.4
12.1
18
10
AAF00
NOMESCO Finland
Ventriculostomy
18.4
12.1
18
10
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
27.2
12.1
16
6
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.3
12.0
36
71
XKD00
NOMESCO Finland
Uroflowmetry
2.9
11.8
73
268
N03AE01
ATC
clonazepam; systemic
3.6
11.8
53
155
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
16.7
11.7
18
11
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
11.6
88
364
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
9.4
11.5
23
25
Q06.9
ICD-10 Finland
Congenital malformation of spinal cord, unspecified
+∞
11.5
11
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.4
11.4
56
175
G04AC01
ATC
NA
4.8
11.3
37
80
S18
ICPC
Laceration/cut
1.8
11.3
255
1671
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
11.2
98
440
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.2
11.0
21
21
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
11.0
85
356
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
44.0
10.9
13
*
SPAT1229
SPAT
Assessment of need for aid
3.8
10.9
46
128
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
8.4
10.9
23
28
J01EA01
ATC
trimethoprim; systemic
1.9
10.8
177
1038
M41.4
ICD-10 Finland
Neuromuscular scoliosis
18.1
10.8
16
9
G04BD07
ATC
tolterodine; oral
4.8
10.7
35
76
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
10.7
136
724
Z31.5
ICD-10 Finland
Genetic counselling
2.7
10.7
73
283
204
Kela drug reimbursment
Leukemia lymphatica
4.6
10.7
36
81
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
10.6
79
323
1530
FHL
Urethrocystoscopy
9.3
10.6
21
23
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
10.2
10.5
20
20
R15
ICD-10 Finland
Faecal incontinence
7.5
10.5
24
33
L28
ICPC
Limited function/disability (L)
2.5
10.5
85
365
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.2
10.5
114
567
74201
ICD-8 Finland
Congenital hydrocephalus, Non communicans
+∞
10.4
10
*
74190
ICD-8 Finland
Spina bifida, Hydrocephalo non indicato, cute tecta
+∞
10.4
10
*
AAJ20
NOMESCO Finland
Excision of epileptic focus
+∞
10.4
10
*
74210
ICD-8 Finland
NA
+∞
10.4
10
*
Q03.1
ICD-10 Finland
Atresia of foramina of Magendie and Luschka
+∞
10.4
10
*
74101
ICD-8 Finland
Spina bifida, Cum hydrocephalo, non cute tecta
+∞
10.4
10
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.6
10.3
29
53
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
10.3
56
189
G40
ICD-10 Finland
Epilepsy
9.7
10.3
20
21
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.6
10.1
45
131
N28
ICPC
Limited function/disability (N)
8.6
10.1
21
25
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.0
239
1583
Q66.0
ICD-10 Finland
Talipes equinovarus
14.8
10.0
16
11
N06AX21
ATC
duloxetine; oral
2.5
9.9
81
349
SPAT1216
SPAT
Assessment of functional ability
2.4
9.9
82
358
R51
ICD-10 Finland
Headache
2.7
9.6
64
246
A02BC02
ATC
pantoprazole; systemic
1.6
9.6
367
2763
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
8.5
9.6
20
24
TKC22
NOMESCO Finland
Catheterisation instruction
8.5
9.6
20
24
A02BC01
ATC
omeprazole; systemic
1.9
9.6
164
971
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
15.3
9.5
15
10
R33
ICD-10 Finland
Retention of urine
4.1
9.4
36
92
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
101.2
9.4
10
*
AAF40
NOMESCO Finland
Shunt of cyst of brain to peritoneum
101.2
9.4
10
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
17.8
9.4
14
8
7424A
ICD-9 Finland
Other congenital anomalies of nervous system, Other specified anomalies of brain
+∞
9.4
9
*
Q05.3
ICD-10 Finland
Sacral spina bifida with hydrocephalus
+∞
9.4
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
9.3
142
806
G47.3
ICD-10 Finland
Sleep apnoea
2.1
9.3
112
578
A28
ICPC
Limited function/disability NOS
2.6
9.2
69
286
J01XE01
ATC
nitrofurantoin; oral
5.7
9.1
25
45
TJF80
NOMESCO Finland
Ostomy education
8.4
9.1
19
23
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
11.6
9.1
16
14
R11
ICD-10 Finland
Nausea and vomiting
2.3
9.0
83
380
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.0
8.9
34
87
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
24.3
8.9
12
5
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.8
8.9
59
225
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
8.9
90
432
H53.4
ICD-10 Finland
Visual field defects
6.0
8.8
23
39
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.8
8.8
28
60
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
16.5
8.6
13
8
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.1
8.5
22
37
G03.9
ICD-10 Finland
Meningitis, unspecified
20.3
8.5
12
6
74199
ICD-8 Finland
Spina bifida, Without mention of hydrocephalus
91.0
8.4
9
*
S06.0
ICD-10 Finland
Concussion
2.1
8.4
92
459
P85
ICPC
Mental retardation
8.0
8.4
18
23
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.9
8.4
14
11
R1250
NOMESCO Finland
Evaluation of functional capability
5.1
8.4
25
50
Q00.0
ICD-10 Finland
Anencephaly
+∞
8.3
8
*
Q04.08
ICD-10 Finland
Congenital malformations of corpus callosum
+∞
8.3
8
*
Q01.1
ICD-10 Finland
Nasofrontal encephalocele
+∞
8.3
8
*
74100
ICD-8 Finland
Spina bifida, Cum hydrocephalo, cute tecta
+∞
8.3
8
*
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
9.6
8.3
16
17
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
9.6
8.3
16
17
H52.2
ICD-10 Finland
Astigmatism
4.3
8.3
29
69
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
14.7
8.2
13
9
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
14.7
8.2
13
9
G04BD08
ATC
solifenacin; oral
3.6
8.1
35
101
N88
ICPC
Epilepsy
9.0
8.1
16
18
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
8.0
318
2385
AAF15
NOMESCO Finland
Ventriculoatrial shunt
22.3
8.0
11
5
N03AX23
ATC
brivaracetam; systemic
22.3
8.0
11
5
WX110
NOMESCO Finland
Local anesthesy
1.6
8.0
527
4461
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.3
7.9
75
351
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
5.2
7.9
23
45
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
7.8
68
302
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.8
168
1066
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
7.1
7.8
18
26
WX402
NOMESCO Finland
General anaesthesia
1.8
7.7
136
810
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.7
147
903
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.1
7.7
84
419
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.8
7.7
129
759
N06AX16
ATC
venlafaxine; oral
1.9
7.6
108
598
N03AG04
ATC
vigabatrin; oral
12.0
7.6
13
11
KH1EE
NOMESCO Finland
Urologic ultrasound examination
12.0
7.6
13
11
J01MA02
ATC
ciprofloxacin; systemic
1.6
7.6
206
1400
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
7.5
58
245
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.8
7.5
45
165
H50.0
ICD-10 Finland
Convergent concomitant strabismus
5.1
7.5
22
44
XCK00
NOMESCO Finland
Perimetry
2.9
7.4
43
153
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
80.8
7.4
8
*
H53.2
ICD-10 Finland
Diplopia
4.1
7.3
27
68
H50.31
ICD-10 Finland
Intermittent exotropia
5.0
7.3
22
45
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.9
7.3
43
155
TJD20
NOMESCO Finland
Change of gastrostomy tube
6.9
7.3
17
25
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
7.3
114
652
74191
ICD-8 Finland
Spina bifida, Hydrocephalo non indicato, non ente tecta
+∞
7.3
7
*
ABE99
NOMESCO Finland
Other operation for spinal malformation
+∞
7.3
7
*
Q03.88
ICD-10 Finland
Other congenital hydrocephalus
+∞
7.3
7
*
7410B
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG CERVIC]
+∞
7.3
7
*
G44.8
ICD-10 Finland
Other specified headache syndromes
5.9
7.3
19
33
H01AC01
ATC
somatropin; parenteral
4.5
7.2
24
55
KDV20
NOMESCO Finland
Submucous urethral injection
30.3
7.2
9
*
R32
ICD-10 Finland
Unspecified urinary incontinence
4.6
7.1
23
51
SPAT1153
SPAT
Removal of sutures
1.7
7.1
166
1079
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.4
7.1
24
56
ZXA00
NOMESCO Finland
Right side
1.8
7.1
140
866
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
7.0
82
421
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.4
7.0
17
27
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.9
104
587
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
13.9
6.9
11
8
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
13.9
6.9
11
8
M05BB03
ATC
alendronic acid and colecalciferol; oral
8.4
6.8
14
17
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.8
543
4698
181
Kela drug reimbursment
Retigabine and vigabatrin
11.1
6.8
12
11
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
9.4
6.8
13
14
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.6
6.8
47
186
XX1XW
NOMESCO Finland
Extensive written report from radiologist
5.7
6.8
18
32
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.4
6.8
23
54
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
16.9
6.8
10
6
N99
ICPC
Neurological disease other
7.3
6.7
15
21
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
6.7
119
710
SPAT1260
SPAT
Consultation of another employee
1.8
6.7
121
729
R52.2
ICD-10 Finland
Other chronic pain
3.6
6.6
28
80
N06AA09
ATC
amitriptyline; systemic
2.5
6.6
50
210
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
8.8
6.6
13
15
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.6
287
2173
ZXA05
NOMESCO Finland
Left side
1.7
6.5
127
781
R4130
NOMESCO Finland
Speech therapy
3.6
6.4
27
77
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
7.5
6.4
14
19
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
9.4
6.3
12
13
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.3
171
1155
M41.5
ICD-10 Finland
Other secondary scoliosis
18.2
6.3
9
5
SPAT1301
SPAT
No procedures
1.6
6.3
206
1461
3360A
ICD-9 Finland
Other diseases of spinal cord, Syringomyelia and syringobulbia
+∞
6.3
6
*
Q04.4
ICD-10 Finland
Septo-optic dysplasia
+∞
6.3
6
*
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
6.3
6
*
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
+∞
6.3
6
*
M49.4*G95.0
ICD-10 Finland
Neuropathic spondylopathy in syringomyelia and syringobulbia
+∞
6.3
6
*
2139
FHL
Other measure in this category
+∞
6.3
6
*
Q06.3
ICD-10 Finland
Other congenital cauda equina malformations
+∞
6.3
6
*
A06AD11
ATC
lactulose; oral
2.1
6.2
67
331
R5110
SPAT
NA
5.4
6.2
17
32
N29
ICPC
Neurological sympt/complt other
4.3
6.2
21
50
H13
ICPC
Plugged feeling ear
1.9
6.1
85
468
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
12.6
6.1
10
8
-
ICD-10 Finland
NA
4.4
6.1
20
46
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
466
2929
2.28
30.81
10.5
7.9
1.21
1.22
mmol/l
0.86
409
2550
433
2666
2.25
29.78
9.8
8.0
1.21
1.22
mmol/l
1.58
404
2467
78
199
4.21
27.89
1.8
3.3
646.49
403.86
mg/l
1.30
73
190
46
75
6.42
27.32
2.6
2.0
—
—
—
0
0
31
37
8.65
24.13
1.6
1.6
—
—
—
0
0
68
183
3.95
22.57
1.7
3.3
3.54
3.55
mmol/l
0.01
63
173
31
43
7.44
21.31
2.1
2.7
—
—
—
0
0
266
1502
2.11
21.13
2.5
2.1
217.97
228.48
u/l
0.05
252
1432
67
193
3.68
20.16
2.0
3.5
41.67
7.05
e6/l
0.93
51
138
67
193
3.68
20.16
2.0
3.5
167.33
264.80
e6/l
0.47
54
143
361
2350
1.92
18.70
5.1
5.3
37.43
36.92
g/l
1.06
331
2208
117
493
2.59
18.21
7.8
10.5
0.64
0.85
mmol/l
0.20
79
382
501
3662
1.88
17.79
6.5
5.5
6.02
6.33
mmol/l
4.04
479
3331
316
2003
1.91
17.47
1.9
1.7
98.70
97.01
pmol/l
0.26
179
1068
785
6767
2.77
17.37
17.8
11.8
139.43
139.56
mmol/l
0.74
770
6576
785
6785
2.74
16.93
17.4
11.8
3.94
3.93
mmol/l
0.37
767
6570
391
2732
1.79
15.26
2.9
2.6
75.87
72.82
nmol/l
0.81
366
2540
32
70
4.71
13.86
6.5
9.5
9.96
9.62
mg/l
0.12
27
65
257
1636
1.81
13.34
4.1
5.2
94.63
92.83
%
0.65
247
1587
582
4661
1.76
13.29
6.6
6.6
83.57
84.54
u/l
0.13
556
4380
285
1898
1.75
12.54
2.8
2.9
2.36
2.36
mmol/l
0.11
255
1705
521
4110
1.68
11.93
8.1
9.6
3.96
3.86
e9/l
0.44
466
3542
116
583
2.14
11.91
6.2
5.3
—
—
—
0
0
138
742
2.02
11.84
1.6
1.7
1144.85
1173.74
nmol/l
0.15
110
574
135
726
2.02
11.56
2.1
2.2
383.52
360.13
nmol/l
0.64
120
680
64
250
2.68
11.52
11.1
9.1
24.31
24.16
mmol/l
0.11
58
231
239
1548
1.75
11.42
2.5
2.3
—
—
—
0
0
173
1020
1.87
11.28
1.5
1.6
58865701.19
38600893.29
pmol/l
0.13
141
886
401
3018
1.61
10.59
5.0
6.3
11.84
13.81
umol/l
0.82
373
2845
45
152
3.07
10.56
2.1
2.4
667.73
227.68
ug/l
0.93
36
137
801
7295
2.36
10.10
9.9
8.8
25.48
26.39
u/l
0.79
787
7075
307
2190
1.62
9.94
5.1
3.1
—
—
—
0
0
181
1126
1.77
9.78
1.6
1.4
21.55
21.00
nmol/l
0.17
157
973
644
5526
1.65
9.20
4.6
3.9
14.59
14.44
pmol/l
0.81
600
5115
233
1585
1.64
8.97
2.4
2.4
3.02
2.79
mg/l
0.67
201
1374
195
1285
1.67
8.44
4.1
2.4
5.71
7.53
e6/l
1.28
176
1116
394
3069
1.52
8.27
4.2
4.1
—
—
—
0
0
125
736
1.82
8.04
7.9
7.5
1.86
1.42
mmol/l
0.86
99
575
161
1021
1.71
8.01
4.2
2.7
1.12
1.00
e6/l
0.21
99
530
571
4846
1.53
7.74
4.3
3.8
9.41
9.26
mm/h
0.12
546
4518
713
6394
1.66
7.34
5.3
4.5
1.72
2.01
mu/l
0.90
669
6019
248
1805
1.52
6.88
3.4
2.9
15.90
27.97
ng/l
1.93
140
929
56
262
2.22
6.88
1.4
1.2
0.24
0.86
u/ml
—
7
14
139
884
1.68
6.79
2.4
4.3
28.39
30.16
s
4.29
130
864
139
886
1.68
6.73
9.6
8.2
1.18
1.17
mmol/l
0.05
131
842
24
73
3.35
6.73
1.0
1.2
64.51
33.63
mg/l
0.83
19
56
135
855
1.69
6.70
2.1
1.9
—
—
—
0
0
133
840
1.69
6.66
2.0
2.4
2.42
2.42
mmol/l
0.06
114
732
107
636
1.78
6.65
14.7
7.6
1.15
1.15
mmol/l
0.00
74
456
239
1741
1.52
6.56
5.3
3.0
0.23
0.31
e6/l
0.37
192
1264
26
85
3.12
6.51
1.1
1.1
—
—
—
0
0
143
932
1.64
6.34
4.9
5.9
0.82
0.82
mmol/l
0.07
134
884
244
1802
1.49
6.22
2.6
2.6
52.79
55.01
u/l
0.47
223
1684
208
1496
1.51
6.00
5.0
3.2
1.02
1.02
kg/l
0.40
34
211
148
987
1.60
5.97
4.7
2.8
3.19
2.83
e6/l
0.20
88
499
252
1897
1.46
5.78
5.6
3.0
20.89
105.29
e6/l
1.48
205
1409
13
28
4.70
5.75
2.3
2.4
27.05
17.53
umol/l
1.32
13
28
613
5420
1.45
5.69
4.7
4.4
36.66
38.08
mmol/mol
4.15
570
5117
238
1780
1.47
5.62
5.4
3.4
0.00
0.00
estimate
1.08
78
657
765
7108
1.67
5.43
16.8
11.0
20.30
20.73
mg/l
0.16
642
5353
80
466
1.79
5.33
1.2
1.2
—
29.19
—
0
19
18
53
3.45
5.33
6.1
4.8
1.94
1.87
ug/l
0.03
18
53
414
3448
1.39
5.24
5.2
3.2
0.00
0.01
estimate
0.80
81
646
20
64
3.18
5.21
1.1
1.1
—
—
—
0
0
409
3409
1.38
5.11
5.1
3.1
0.00
0.00
estimate
0.00
79
644
409
3413
1.38
5.05
6.8
4.4
0.01
0.00
estimate
0.42
77
667
23
82
2.85
5.01
1.0
1.0
—
—
—
0
0
152
1065
1.52
4.89
3.1
3.8
996.42
881.17
ng/l
0.21
125
871
420
3540
1.36
4.78
3.3
2.9
73.80
79.01
ug/l
0.36
397
3335
26
102
2.60
4.75
2.3
2.4
16.68
16.79
%
0.04
16
54
90
561
1.67
4.73
2.5
3.3
0.22
0.22
g/l
0.22
81
534
197
1464
1.45
4.72
1.9
2.5
0.83
1.16
mg/l
1.12
150
1074
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
17
53
3.25
4.63
1.1
1.3
—
—
—
0
0
9
11
8.25
4.57
2.6
3.0
21.44
28.26
umol/l
—
9
11
95
609
1.63
4.49
1.9
1.8
—
—
—
0
0
421
3579
1.34
4.41
6.4
6.7
54.61
54.32
%
0.18
402
3398
88
559
1.64
4.32
1.6
1.7
20.42
20.49
iu/l
0.01
68
453
95
616
1.61
4.29
2.1
1.9
—
—
—
0
0
66
389
1.75
4.26
1.6
1.8
7.80
8.44
u/l
0.18
45
299
318
2609
1.35
4.15
5.2
3.1
—
—
—
0
0
656
5994
1.39
4.15
4.0
3.4
5.60
5.67
mmol/l
1.06
605
5563
423
3623
1.33
4.10
6.7
6.9
31.00
31.19
%
0.12
401
3435
10
23
4.39
4.09
2.3
2.8
0.96
1.06
umol/l
—
10
23
15
47
3.23
4.07
1.1
1.3
—
—
—
0
0
56
320
1.80
4.02
2.1
3.2
66.48
66.80
g/l
0.15
50
299
28
124
2.30
4.00
2.0
2.4
137.48
133.02
g/l
0.38
21
96
86
557
1.60
3.91
8.2
7.9
23.86
23.71
mmol/l
0.26
80
533
32
152
2.15
3.88
1.8
1.4
—
—
—
0
0
127
908
1.47
3.69
3.0
2.4
13.51
14.34
umol/l
0.64
118
846
74
471
1.62
3.63
18.1
13.7
1.26
1.17
inr
—
7
75
31
150
2.11
3.61
1.9
1.5
—
—
—
0
0
53
860
0.59
3.45
1.5
1.5
—
—
—
0
0
278
2291
1.31
3.38
3.5
3.5
29.00
30.95
u/l
0.47
261
2185
23
478
0.47
3.37
1.6
1.5
—
—
—
0
0
64
405
1.63
3.23
6.7
3.3
1.23
1.23
mmol/l
0.26
55
347
77
510
1.56
3.22
2.9
2.7
—
—
—
0
0
14
49
2.89
3.20
1.0
1.1
1.25
1.08
u/l
—
6
21
20
85
2.39
3.17
2.8
4.0
—
—
—
0
0
105
746
1.46
3.16
3.4
2.6
21.74
23.52
%
0.68
93
660
62
392
1.63
3.15
2.2
1.7
—
—
—
0
0
636
5873
1.32
3.12
11.0
8.9
99.20
93.12
ml/min/173m2
8.65
539
4620
48
285
1.72
3.08
1.7
1.6
—
—
—
0
0
114
830
1.43
3.02
3.2
2.4
2.48
2.44
g/l
0.26
106
768
93
652
1.48
3.00
1.3
1.2
99.06
154.33
iu/ml
1.16
30
273
5
5
10.05
2.98
1.2
1.4
—
—
—
0
0
834
8105
1.86
2.83
23.3
16.3
267.28
261.52
e9/l
1.83
825
7896
83
580
1.48
2.73
2.1
2.4
24.70
115.65
u/l
0.55
71
482
834
8112
1.84
2.71
23.3
16.2
4.54
4.56
e12/l
0.53
823
7883
29
154
1.91
2.68
2.5
2.1
0.35
3.14
ug/l
0.92
24
139
52
329
1.62
2.67
1.6
1.4
—
—
—
0
0
23
438
0.51
2.65
1.4
1.5
—
—
—
0
0
19
88
2.19
2.52
3.0
3.9
11.38
10.40
%
0.16
13
72
24
440
0.53
2.47
1.4
1.5
—
—
—
0
0
24
439
0.53
2.45
1.4
1.5
—
—
—
0
0
24
439
0.53
2.45
1.4
1.4
—
—
—
0
0
34
561
0.59
2.41
1.4
1.5
—
—
—
0
0
9
27
3.36
2.39
1.1
1.2
—
—
—
0
0
49
315
1.59
2.38
2.3
2.2
7.16
6.64
ug/l
0.06
42
282
9
28
3.24
2.31
1.0
1.2
—
—
—
0
0
9
28
3.24
2.31
1.1
1.3
—
—
—
0
0
82
593
1.42
2.29
1.6
1.3
498.84
238.81
u/ml
0.29
73
553
13
53
2.48
2.28
1.2
1.2
—
—
—
0
0
112
860
1.35
2.19
3.2
3.8
1.50
2.08
ug/l
0.80
103
779
146
1165
1.30
2.19
1.3
1.3
25.79
26.52
iu/ml
0.03
51
346
31
181
1.74
2.18
1.6
1.8
—
—
—
0
0
34
204
1.69
2.17
1.9
2.0
—
—
—
0
0
11
43
2.58
2.10
1.8
2.3
—
—
—
0
0
21
110
1.93
2.07
6.3
2.9
4.92
4.91
kpa
0.03
21
110
229
1952
1.24
1.99
1.7
1.5
1.89
1.97
g/l
0.37
140
1154
7
21
3.35
1.97
1.0
1.0
86.66
107.98
nmol/l
—
7
14
8
27
2.98
1.94
1.1
1.3
—
—
—
0
0
19
99
1.94
1.91
1.8
1.5
—
—
—
0
0
5
12
4.18
1.82
3.8
3.3
—
—
—
0
0
34
216
1.60
1.79
1.9
2.1
—
—
—
0
0
203
1727
1.23
1.78
3.9
3.4
7.35
8.33
mmol/l
1.90
184
1507
142
1163
1.26
1.75
2.4
2.7
140.92
98.67
ug/g
0.84
105
921
27
163
1.68
1.73
1.4
1.4
16.85
19.26
u/l
0.17
22
142
58
792
0.71
1.72
1.6
1.5
—
—
—
0
0
99
776
1.31
1.71
2.7
3.9
4.76
6.64
umol/l
1.59
88
648
16
82
1.97
1.70
1.3
1.3
0.70
0.48
nmol/l
0.41
16
77
65
478
1.39
1.70
1.3
1.6
339.21
310.43
mu/l
0.28
58
435
23
380
0.59
1.70
2.1
1.7
—
—
—
0
0
42
285
1.50
1.67
1.3
1.3
—
—
—
0
0
509
4733
1.18
1.66
3.7
3.1
43.16
37.10
u/l
0.77
480
4521
8
31
2.60
1.66
3.3
4.3
197.88
125.38
ug/l
—
8
31
250
2189
1.20
1.63
1.3
1.5
1.04
2.23
u/ml
1.93
68
534
27
424
0.63
1.63
1.5
1.6
—
—
—
0
0
45
314
1.46
1.58
2.0
3.6
76.46
153.07
ng/l
2.04
37
283
13
64
2.05
1.54
1.9
3.3
26.02
27.19
umol/l
0.19
13
64
10
205
0.48
1.52
1.7
1.2
—
—
—
0
0
7
27
2.61
1.51
2.3
1.8
—
—
—
0
0
7
27
2.61
1.51
1.4
1.3
—
—
—
0
0
7
27
2.61
1.51
1.0
1.2
—
—
—
0
0
7
27
2.61
1.51
1.4
1.3
—
—
—
0
0
667
6390
1.19
1.38
18.7
14.0
13.44
13.38
%
0.40
658
6278
31
207
1.52
1.37
1.6
1.7
100.27
101.35
u/ml
0.02
11
28
9
42
2.15
1.34
2.7
1.7
—
—
—
0
0
6
24
2.51
1.30
2.3
1.8
—
—
—
0
0
41
295
1.41
1.26
1.2
1.2
—
—
—
0
0
85
685
1.27
1.24
3.7
3.6
22.13
21.18
%
0.20
37
255
6
26
2.32
1.19
2.3
1.7
—
—
—
0
0
17
102
1.68
1.17
2.4
1.8
—
—
—
0
0
729
7070
1.20
1.16
16.7
12.5
39.98
40.12
%
0.21
552
5904
15
87
1.74
1.15
1.8
1.3
—
—
—
0
0
13
72
1.82
1.15
2.0
8.7
5.52
6.49
mmol/l
1.38
13
58
13
73
1.79
1.11
2.2
1.8
—
—
—
0
0
23
339
0.67
1.10
1.6
1.5
—
—
—
0
0
160
1395
1.18
1.10
2.2
2.9
319.62
4490.44
umol/l
4.00
141
1251
5
21
2.39
1.09
1.6
1.3
—
—
—
0
0
5
21
2.39
1.09
1.6
1.3
—
—
—
0
0
42
315
1.35
1.05
12.5
13.2
1.13
1.13
mg/l
0.01
42
301
20
130
1.55
1.03
2.5
2.3
—
—
—
0
0
18
115
1.58
1.00
2.9
1.7
—
—
—
0
0
34
250
1.37
0.97
1.6
1.6
—
—
—
0
0
6
27
2.23
0.93
2.3
1.9
—
—
—
0
0
6
27
2.23
0.93
2.3
1.9
—
—
—
0
0
58
465
1.27
0.92
2.3
2.2
11.64
12.22
nmol/l
0.19
48
421
9
52
1.74
0.92
1.4
2.7
105.56
106.13
mmol/l
—
9
52
19
126
1.52
0.92
1.0
1.2
—
—
—
0
0
6
28
2.15
0.91
2.3
1.9
—
—
—
0
0
72
594
1.23
0.90
3.4
3.3
31.09
31.59
%
0.14
57
423
110
951
1.18
0.86
3.4
3.4
254.37
612.88
ng/l
0.91
63
577
20
137
1.47
0.84
2.8
1.8
—
—
—
0
0
24
173
1.40
0.79
1.1
1.1
—
—
—
0
0
6
33
1.82
0.79
1.0
1.6
3.62
4.23
nmol/l
—
6
33
8
48
1.67
0.79
1.3
1.1
—
—
—
0
0
8
48
1.67
0.79
1.3
1.1
87.50
86.25
%
—
8
48
21
148
1.43
0.78
1.9
1.3
—
—
—
0
0
21
148
1.43
0.78
1.9
1.3
—
—
—
0
0
6
34
1.77
0.76
2.3
1.8
—
—
—
0
0
6
34
1.77
0.76
2.3
1.8
—
—
—
0
0
6
34
1.77
0.76
2.3
1.8
—
—
—
0
0
6
34
1.77
0.76
2.3
1.8
—
—
—
0
0
50
405
1.25
0.76
2.8
2.4
67.71
77.28
ml/min/173m2
0.81
21
160
126
1115
1.15
0.75
1.3
1.2
10.21
9.92
u/ml
0.02
52
445
5
24
2.09
0.74
8.6
5.6
—
—
—
0
0
646
6275
1.12
0.72
4.0
3.8
2.81
2.85
mmol/l
0.55
605
5902
642
6235
1.12
0.72
3.7
3.6
4.61
4.71
mmol/l
1.89
605
5904
74
630
1.19
0.71
3.1
2.3
3049.97
4476.79
u/l
0.27
22
262
144
1292
1.14
0.71
3.9
4.1
5.28
9.43
mg/mmol
1.21
94
846
5
26
1.93
0.70
1.2
1.1
81.14
37.85
u/ml
—
5
26
5
26
1.93
0.70
1.6
5.5
—
—
—
0
0
22
296
0.74
0.69
1.1
1.2
6.81
5.98
u/ml
0.09
14
198
7
42
1.67
0.68
1.0
1.1
—
—
—
0
0
19
136
1.41
0.67
1.2
2.1
6.69
7.34
g/l
1.01
14
112
19
136
1.41
0.67
1.2
2.1
3.51
3.68
g/l
0.21
13
105
19
136
1.41
0.67
1.2
2.1
—
—
—
0
0
16
111
1.45
0.66
2.1
1.7
—
—
—
0
0
12
78
1.55
0.65
1.9
1.3
—
—
—
0
0
15
103
1.46
0.65
1.7
2.5
216.84
99.00
ug/min
—
7
64
12
79
1.53
0.63
1.9
1.3
—
—
—
0
0
12
79
1.53
0.63
1.9
1.3
—
—
—
0
0
12
79
1.53
0.63
1.9
1.3
—
—
—
0
0
12
79
1.53
0.63
1.9
1.3
—
—
—
0
0
26
200
1.31
0.61
2.5
1.9
7.41
5.10
iu/l
0.19
11
70
8
51
1.57
0.60
1.9
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
31
245
1.28
0.60
1.7
1.6
253.89
205.32
u/ml
0.38
19
129
15
209
0.71
0.60
1.8
1.6
—
—
—
0
0
12
80
1.51
0.60
1.9
1.3
—
—
—
0
0
22
288
0.76
0.60
1.1
1.2
1.06
4.05
u/ml
—
10
88
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
11
73
1.51
0.56
1.9
1.6
—
—
—
0
0
10
65
1.54
0.55
1.1
1.2
—
—
—
0
0
10
65
1.54
0.55
2.5
2.3
0.18
0.12
nmol/l
—
10
45
6
37
1.63
0.55
1.0
1.1
1415.00
1493.43
miu/ml
—
6
37
13
90
1.45
0.55
2.4
1.7
—
—
—
0
0
32
394
0.80
0.55
1.6
1.9
—
—
—
0
0
115
1038
1.12
0.54
1.9
1.7
1.47
1.39
%
0.88
100
949
22
170
1.30
0.52
1.2
1.4
374.29
342.37
ug/g
0.30
14
93
609
5939
1.09
0.51
3.3
3.2
1.24
1.23
mmol/l
0.03
567
5609
18
135
1.34
0.51
1.4
1.2
—
—
—
0
0
6
41
1.47
0.50
1.0
1.0
—
—
—
0
0
23
180
1.29
0.50
1.4
1.2
34.04
11.97
u/ml
—
5
29
24
189
1.28
0.50
3.7
1.9
—
—
—
0
0
634
6198
1.09
0.49
3.6
3.5
1.43
1.47
mmol/l
1.22
594
5851
24
191
1.26
0.47
3.3
1.9
—
—
—
0
0
51
586
0.86
0.44
1.1
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
130
1.31
0.44
3.6
15.0
0.29
0.38
u/ml
—
9
77
11
78
1.42
0.43
1.5
1.7
—
—
—
0
0
27
327
0.82
0.42
1.1
1.2
3.31
2.17
u/ml
0.22
13
179
18
140
1.29
0.42
1.7
1.3
—
—
—
0
0
5
33
1.52
0.41
2.8
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
—
—
0
0
11
79
1.40
0.41
1.5
1.3
—
—
—
0
0
30
357
0.83
0.40
2.5
4.2
3.36
20.78
ug/l
0.77
22
277
0
18
0.00
0.40
0.0
1.2
—
9.42
—
0
18
48
548
0.87
0.39
1.3
1.3
—
—
—
0
0
8
61
1.31
0.39
1.6
1.4
—
—
—
0
0
7
104
0.67
0.39
1.4
1.5
—
—
—
0
0
173
1840
0.93
0.39
2.5
2.3
—
—
—
0
0
7
106
0.66
0.39
1.0
1.9
—
—
—
0
0
157
1676
0.92
0.39
2.5
2.2
—
—
—
0
0
17
133
1.28
0.38
4.6
3.9
3.84
4.08
e9/l
0.21
17
133
5
36
1.39
0.38
2.2
2.4
—
1401.00
—
0
5
5
36
1.39
0.38
2.4
1.3
—
—
—
0
0
6
42
1.43
0.35
1.5
3.3
—
—
—
0
0
18
144
1.26
0.35
1.7
1.8
171.39
209.32
pmol/l
0.73
18
136
17
135
1.26
0.35
5.9
4.2
54.65
55.38
%
0.09
17
135
6
43
1.40
0.35
1.5
1.2
—
79.29
—
0
7
6
44
1.37
0.34
3.5
1.5
—
—
—
0
0
25
209
1.20
0.34
1.4
1.6
—
266.67
—
0
6
11
82
1.35
0.34
3.5
1.7
—
—
—
0
0
11
83
1.33
0.32
1.0
1.0
1.65
1.37
g/l
1.14
11
74
27
230
1.18
0.31
1.2
1.1
—
—
—
0
0
17
138
1.24
0.30
1.4
1.2
—
1.06
—
0
9
7
54
1.30
0.30
1.7
1.6
0.97
1.06
g/l
—
7
54
10
75
1.34
0.30
1.3
1.6
—
—
—
0
0
46
514
0.89
0.30
2.0
2.5
0.52
0.67
ug/l
1.90
31
275
31
355
0.87
0.29
1.5
1.7
5.71
2.77
mg/l
0.89
20
233
13
162
0.80
0.28
1.3
2.2
8.32
10.54
mg/l
0.75
13
148
8
66
1.21
0.26
1.5
2.8
—
—
—
0
0
5
72
0.69
0.26
1.0
1.1
—
—
—
0
0
5
72
0.69
0.26
1.0
1.1
—
—
—
0
0
5
72
0.69
0.26
1.0
1.2
—
—
—
0
0
5
72
0.69
0.26
1.0
1.2
—
—
—
0
0
5
73
0.68
0.26
1.0
1.2
—
—
—
0
0
29
330
0.87
0.25
1.4
1.8
—
—
—
0
0
17
142
1.20
0.24
1.1
2.1
—
—
—
0
0
26
228
1.14
0.23
1.2
1.1
—
—
—
0
0
160
1533
1.05
0.22
1.6
1.7
1.31
1.39
mmol/l
0.62
146
1334
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
8
104
0.77
0.21
1.1
1.1
—
—
—
0
0
5
43
1.16
0.21
2.0
2.4
309.60
705.35
u/ml
—
5
43
20
173
1.16
0.21
1.5
1.9
—
—
—
0
0
36
397
0.90
0.20
1.2
1.3
192.83
256.40
miu/ml
0.50
17
203
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
10
122
0.82
0.19
1.4
1.2
—
—
—
0
0
11
130
0.84
0.16
1.1
1.1
—
—
—
0
0
6
79
0.76
0.15
1.3
1.1
—
—
—
0
0
14
121
1.16
0.15
1.2
1.2
120.71
112.98
%
0.48
14
111
9
83
1.09
0.14
1.6
1.6
—
—
—
0
0
19
211
0.90
0.13
1.0
1.1
8.01
9.71
u/ml
0.14
11
96
23
251
0.91
0.12
1.6
1.3
—
—
—
0
0
12
105
1.14
0.11
1.1
1.1
—
—
—
0
0
12
105
1.14
0.11
3.2
1.6
—
—
—
0
0
11
96
1.15
0.10
1.5
1.3
—
—
—
0
0
49
467
1.05
0.10
1.8
1.8
—
—
—
0
0
12
134
0.89
0.08
1.1
1.2
2.83
5.77
u/ml
—
6
53
6
56
1.07
0.08
2.3
1.7
—
—
—
0
0
6
56
1.07
0.08
2.3
1.8
—
—
—
0
0
6
56
1.07
0.08
2.3
1.8
—
—
—
0
0
10
113
0.88
0.08
1.6
1.4
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
16
174
0.92
0.07
1.7
1.3
45.38
65.25
pmol/l
1.94
16
169
17
184
0.92
0.07
1.0
1.1
4.45
0.31
u/ml
—
6
63
7
81
0.86
0.07
3.0
1.6
—
—
—
0
0
9
88
1.02
0.07
1.1
1.1
98.00
92.78
%
—
9
82
155
1524
1.02
0.06
1.6
1.5
—
—
—
0
0
30
287
1.05
0.05
1.4
1.5
—
—
—
0
0
94
924
1.02
0.04
2.1
1.9
—
—
—
0
0
17
160
1.06
0.04
1.2
1.1
—
—
—
0
0
115
1136
1.01
0.03
2.2
2.0
—
—
—
0
0
234
2325
1.01
0.02
2.0
1.7
—
—
—
0
0
23
239
0.96
0.02
1.7
1.5
0.02
0.03
iu/ml
0.21
11
43
622
6228
1.00
0.01
3.7
3.8
—
—
—
0
0
12
126
0.95
0.00
3.2
3.5
37.92
27.75
mg/l
—
5
87
10
104
0.96
0.00
1.8
1.6
7.26
7.31
mmol/l
—
5
68
34
338
1.01
0.00
1.3
1.4
—
—
—
0
0
31
309
1.00
0.00
1.2
1.4
—
—
—
0
0
19
189
1.01
0.00
1.0
1.1
2.44
7.07
u/ml
1.90
12
94
36
357
1.01
0.00
2.0
2.1
23.56
36.58
u/ml
0.82
36
341
0
6
0.00
0.00
0.0
1.0
—
65.67
—
0
6
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
0.00
2.2
3.0
15.20
71.57
u/ml
—
5
51
6
64
0.94
0.00
1.3
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
9
95
0.95
0.00
1.8
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
7
69
1.01
0.00
1.1
1.3
—
339.09
—
0
11
0
5
0.00
0.00
0.0
2.0
—
462.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_NERVOUS_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_NERVOUS_SYSTEM | 2.691 [2.25, 3.23] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.139 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 4093 females with Q17_CONGEN_MALFO_NERVOUS_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_NERVOUS_SYSTEM | 3.066 [2.48, 3.79] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 242 out of 3664 males with Q17_CONGEN_MALFO_NERVOUS_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_NERVOUS_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.659% |
| 5 | 1.631% | 3.359% |
| 10 | 3.77% | 7.849% |
| 15 | 7.188% | 14.821% |
| 20 | 12.271% | 23.606% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_NERVOUS_SYSTEM – Congenital malformations of the nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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