No definition available.
Congenital malformations of the nervous system
DOID EFO Endpoint Browser PheWeb
Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
827 |
4. Check minimum number of eventsNone |
827 |
5. Include endpoints |
893 |
6. Filter based on genotype QC (FinnGen only) |
851 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q
- Name in latin
- Malformationes congenitae systematis nervosi
Similar endpoints
↥List of similar endpoints to
Congenital malformations of the nervous system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10956 | 5699 | 5233 |
| Only index persons | 8283 | 4517 | 3766 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.16 | 0.15 |
| Only index persons | 0.16 | 0.17 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 10.11 | 14.17 | 5.54 |
| Only index persons | 14.66 | 19.57 | 8.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 851 | 581 | 270 |
| Unadjusted period prevalence (%) | 0.18 | 0.21 | 0.12 |
| Median age at first event (years) | 29.31 | 30.84 | 26.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 893
- Matched controls
- 8930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
+∞
307.7
346
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.4
115.3
167
238
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
67.7
114.6
63
10
ABE50
NOMESCO Finland
Occipitocervical decompression
+∞
109.7
103
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
13.4
104.6
103
86
G91.1
ICD-10 Finland
Obstructive hydrocephalus
38.7
93.6
58
16
N03AX14
ATC
levetiracetam; systemic
10.9
88.8
100
102
Q04.8
ICD-10 Finland
Other specified congenital malformations of brain
+∞
88.0
83
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.5
85.4
192
422
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.4
84.0
196
445
N03AF02
ATC
oxcarbazepine; oral
7.9
76.2
112
160
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.0
72.6
104
144
183
Kela drug reimbursment
Lamotrigin and topiramate
14.2
70.6
66
50
N05BA09
ATC
clobazam; oral
15.2
67.0
60
42
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.7
65.6
111
184
AA1AD
NOMESCO Finland
CT of head and brain
3.6
63.5
271
953
N03AX18
ATC
lacosamide; systemic
17.8
59.5
49
29
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.6
58.7
62
57
Q04.6
ICD-10 Finland
Congenital cerebral cysts
+∞
56.9
54
*
R51.80
ICD-10 Finland
Headache
3.3
54.0
280
1099
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
10.4
51.2
58
59
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
140.7
50.4
53
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
19.8
48.6
38
20
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
14.1
46.2
43
32
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
44.1
42
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.6
43.1
110
263
N03AX11
ATC
topiramate; oral
6.3
41.3
72
122
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
80.9
41.3
46
6
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
39.9
38
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
13.7
39.3
37
28
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
8.2
38.2
52
67
XKC03
NOMESCO Finland
Water cystometry
7.5
36.8
54
76
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
36.1
118
338
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
35.8
101
260
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
35.7
34
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
34.6
33
*
Q07.8
ICD-10 Finland
Other specified congenital malformations of nervous system
+∞
34.6
33
*
G93.0
ICD-10 Finland
Cerebral cysts
43.9
34.3
42
10
Q05.7
ICD-10 Finland
Lumbar spina bifida without hydrocephalus
+∞
33.5
32
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
8.0
33.4
46
60
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
11.7
32.8
34
30
2133
FHL
Suntin revisio
323.7
31.0
31
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
30.9
135
466
N03AG01
ATC
valproic acid; systemic, rectal
3.7
30.5
104
306
G91.0
ICD-10 Finland
Communicating hydrocephalus
29.8
30.0
40
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
29.9
178
730
N03AX09
ATC
lamotrigine; oral
3.8
29.7
98
282
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
29.3
28
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
29.3
28
*
Q05.9
ICD-10 Finland
Spina bifida, unspecified
301.3
28.9
29
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
28.8
104
318
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
8.5
28.4
37
45
7410D
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG LUMBALIS]
+∞
28.3
27
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
28.1
231
1107
R42
ICD-10 Finland
Dizziness and giddiness
2.6
27.7
196
875
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
48.8
27.6
33
7
N05CD08
ATC
midazolam; nasal, systemic
6.0
27.4
49
85
N03AX12
ATC
[U] gabapentin; oral
2.8
27.4
159
642
Q06.8
ICD-10 Finland
Other specified congenital malformations of spinal cord
+∞
26.2
25
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.7
25.6
61
137
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
36.8
25.4
32
9
M03BX01
ATC
baclofen; systemic
7.2
25.2
38
55
Q02
ICD-10 Finland
Microcephaly
+∞
25.1
24
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.8
25.1
59
131
XKD06
NOMESCO Finland
Physiologic investigation of micturition
6.7
24.9
40
62
F83
ICD-10 Finland
Mixed specific developmental disorders
6.2
24.9
43
72
H47.2
ICD-10 Finland
Optic atrophy
30.1
24.2
32
11
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.5
23.9
47
89
AA1AA
NOMESCO Finland
Head X-ray examination
8.8
23.8
30
35
N05BA01
ATC
diazepam; systemic, rectal
2.8
23.2
132
525
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
22.5
136
558
UKC02
NOMESCO Finland
Cystoscopy
3.0
22.1
105
378
G40
ICD-10 Finland
Epilepsy
8.7
22.0
28
33
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
21.1
262
1469
R4120
NOMESCO Finland
Occupational therapy
3.2
21.0
90
305
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
61.6
21.0
24
*
2132
FHL
Ventricular operators sunt
+∞
20.9
20
*
G04AC01, ,
ATC
5.5
20.3
40
76
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
20.3
223
1190
N03AX16
ATC
[U] pregabalin
2.3
19.9
188
943
Q04.9
ICD-10 Finland
Congenital malformation of brain, unspecified
+∞
19.9
19
*
Q01.8
ICD-10 Finland
Encephalocele of other sites
+∞
19.9
19
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.9
19.8
99
366
N03AF01
ATC
carbamazepine; oral, rectal
3.9
19.7
59
158
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
47.1
19.3
23
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
19.1
303
1845
G44.2
ICD-10 Finland
Tension-type headache
2.3
18.9
162
778
R62.0
ICD-10 Finland
Delayed milestone
4.6
18.9
45
101
Z2445
NOMESCO Finland
Psychologist
2.9
18.9
94
347
F82
ICD-10 Finland
Specific developmental disorder of motor function
6.1
18.8
33
56
N03AX22
ATC
perampanel; oral
24.3
18.7
26
11
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
18.7
89
320
G40.10
ICD-10 Finland
Simple partial seizures
15.5
18.5
30
20
XKD00
NOMESCO Finland
Uroflowmetry
3.0
18.5
87
311
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
16.6
18.4
29
18
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.9
18.2
33
58
N03AE01
ATC
clonazepam; systemic
3.6
18.1
61
177
Z3226
NOMESCO Finland
Physiotherapist
2.1
17.9
194
1024
G04BD04
ATC
oxybutynin; oral, transdermal
3.6
17.7
59
170
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.6
17.7
34
63
J01XE01
ATC
nitrofurantoin; oral
6.7
17.6
28
43
Z31.5
ICD-10 Finland
Genetic counselling
2.8
17.5
92
349
N28
ICPC
Limited function/disability (N)
7.9
17.5
24
31
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
17.3
74
250
L28
ICPC
Limited function/disability (L)
2.5
17.3
122
537
TAB00
NOMESCO Finland
Lumbar puncture
3.3
17.2
67
214
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
16.9
124
555
H53.4
ICD-10 Finland
Visual field defects
5.9
16.7
30
52
G91.8
ICD-10 Finland
Other hydrocephalus
35.8
16.7
21
6
Q07.9
ICD-10 Finland
Congenital malformation of nervous system, unspecified
+∞
16.7
16
*
Q04.3
ICD-10 Finland
Other reduction deformities of brain
+∞
16.7
16
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
16.7
326
2107
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
13.7
16.5
28
21
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
16.5
103
427
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.0
16.5
77
274
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
30.7
16.2
21
7
WX402
NOMESCO Finland
General anaesthesia
2.0
16.1
220
1260
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
15.8
64
209
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
6.7
15.8
25
38
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
16.0
15.8
25
16
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
15.7
15
*
Q06.9
ICD-10 Finland
Congenital malformation of spinal cord, unspecified
+∞
15.7
15
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.7
15.6
29
52
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
15.5
97
402
N88
ICPC
Epilepsy
12.6
15.4
27
22
R15
ICD-10 Finland
Faecal incontinence
5.3
15.4
31
60
R4110
NOMESCO Finland
Physiotherapy
1.9
15.3
243
1462
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
15.3
182
991
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
45.8
15.1
18
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
15.1
177
958
204
Kela drug reimbursment
Leukemia lymphatica
4.3
15.0
39
94
A28
ICPC
Limited function/disability NOS
2.5
14.9
99
422
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
14.8
123
580
R51
ICD-10 Finland
Headache
2.7
14.8
82
320
7419D
ICD-9 Finland
Spina bifida, Without mention of hydrocephalus[SPINA BIFIDA APERTA SINE HYDROCEPHALO REG LUMBALIS]
+∞
14.6
14
*
Q05.0
ICD-10 Finland
Cervical spina bifida with hydrocephalus
+∞
14.6
14
*
Q04.00
ICD-10 Finland
Agenesis of corpus callosum
+∞
14.6
14
*
G04BD07
ATC
tolterodine; oral
4.2
14.4
39
97
SPAT1229
SPAT
Assessment of need for aid
3.3
14.3
54
169
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
43.2
14.1
17
*
N03AX15
ATC
zonisamide; oral
14.7
14.1
23
16
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.0
14.1
25
43
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
14.0
67
241
L89
ICD-10 Finland
Decubitus ulcer and pressure area
10.3
14.0
27
27
AAJ20
NOMESCO Finland
Excision of epileptic focus
54.2
13.8
16
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.4
13.7
102
458
TKC22
NOMESCO Finland
Catheterisation instruction
6.6
13.7
22
34
H50.1
ICD-10 Finland
Divergent concomitant strabismus
12.3
13.6
24
20
Q05.8
ICD-10 Finland
Sacral spina bifida without hydrocephalus
+∞
13.6
13
*
AAF00
NOMESCO Finland
Ventriculostomy
15.3
13.1
21
14
N03AX23
ATC
brivaracetam; systemic
19.4
12.9
19
10
M41.4
ICD-10 Finland
Neuromuscular scoliosis
19.4
12.9
19
10
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
14.3
12.8
21
15
74101
ICD-8 Finland
Spina bifida, Cum hydrocephalo, non cute tecta
+∞
12.5
12
*
74201
ICD-8 Finland
Congenital hydrocephalus, Non communicans
+∞
12.5
12
*
Q01.1
ICD-10 Finland
Nasofrontal encephalocele
+∞
12.5
12
*
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.6
12.4
73
293
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.0
12.4
57
201
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.2
12.3
107
513
P85
ICPC
Mental retardation
9.2
12.3
25
28
G03.9
ICD-10 Finland
Meningitis, unspecified
27.1
12.1
16
6
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
27.1
12.1
16
6
Q66.0
ICD-10 Finland
Talipes equinovarus
27.1
12.1
16
6
N29
ICPC
Neurological sympt/complt other
5.1
12.0
25
50
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
12.0
104
499
G44.8
ICD-10 Finland
Other specified headache syndromes
4.6
12.0
28
62
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.8
11.9
27
58
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
47.3
11.9
14
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
11.9
289
1951
TJF80
NOMESCO Finland
Ostomy education
11.9
11.9
21
18
J01EA01
ATC
trimethoprim; systemic
1.8
11.8
215
1336
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
11.8
135
720
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
9.8
11.8
23
24
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
11.7
211
1307
Z2446
NOMESCO Finland
Social worker
2.2
11.7
104
504
A02BC01
ATC
omeprazole; systemic
1.8
11.6
202
1237
SPAT1216
SPAT
Assessment of functional ability
2.2
11.5
102
493
Q03.1
ICD-10 Finland
Atresia of foramina of Magendie and Luschka
+∞
11.5
11
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.3
11.4
44
140
RS222, ,
NOMESCO Finland
5.2
11.3
23
45
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
12.9
11.2
19
15
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
11.0
91
427
G04BD08
ATC
solifenacin; oral
3.1
11.0
45
148
G40.89
ICD-10 Finland
Other epilepsy
14.1
11.0
18
13
H53.2
ICD-10 Finland
Diplopia
3.8
10.9
33
89
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
10.9
143
800
S97
ICPC
Chronic ulcer skin
3.2
10.8
42
134
R11
ICD-10 Finland
Nausea and vomiting
2.2
10.8
100
492
N99
ICPC
Neurological disease other
9.7
10.8
21
22
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
10.8
58
223
N06AX21
ATC
duloxetine; oral
2.1
10.7
109
556
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.1
10.7
18
14
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
10.6
88
414
XCK00
NOMESCO Finland
Perimetry
3.0
10.5
46
158
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
111.3
10.4
11
*
74210, ,
ICD-8 Finland
+∞
10.4
10
*
74190
ICD-8 Finland
Spina bifida, Hydrocephalo non indicato, cute tecta
+∞
10.4
10
*
74100
ICD-8 Finland
Spina bifida, Cum hydrocephalo, cute tecta
+∞
10.4
10
*
AAF40
NOMESCO Finland
Shunt of cyst of brain to peritoneum
+∞
10.4
10
*
Q05.3
ICD-10 Finland
Sacral spina bifida with hydrocephalus
+∞
10.4
10
*
H01AC01
ATC
somatropin; parenteral
4.3
10.4
27
65
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
16.3
10.4
16
10
1530
FHL
Urethrocystoscopy
8.3
10.4
22
27
ZXD05
NOMESCO Finland
Urgent procedure
1.7
10.4
260
1760
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
23.7
10.3
14
6
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
4.3
10.1
26
62
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
10.0
99
499
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
14.8
10.0
16
11
Z3231
NOMESCO Finland
Registered nurse
1.7
10.0
249
1681
S18
ICPC
Laceration/cut
1.6
9.9
337
2453
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
9.9
71
313
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.1
9.9
41
136
KH1EE
NOMESCO Finland
Urologic ultrasound examination
16.9
9.9
15
9
N03AG04
ATC
vigabatrin; oral
13.6
9.7
16
12
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
9.6
76
351
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.1
9.6
96
487
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
15.2
9.5
15
10
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
15.2
9.5
15
10
WX882
NOMESCO Finland
High dependency care
2.6
9.5
53
208
SPAT1255
SPAT
Intravenous administration of medicine
2.7
9.4
49
185
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
9.4
187
1184
N03AF03
ATC
rufinamide; oral
101.1
9.4
10
*
Q04.08
ICD-10 Finland
Congenital malformations of corpus callosum
+∞
9.4
9
*
74199
ICD-8 Finland
Spina bifida, Without mention of hydrocephalus
+∞
9.4
9
*
ABE99
NOMESCO Finland
Other operation for spinal malformation
+∞
9.4
9
*
Q00.0
ICD-10 Finland
Anencephaly
+∞
9.4
9
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.4
9.4
23
53
ZXE00
NOMESCO Finland
One hour or less
1.6
9.2
336
2479
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.7
9.2
48
182
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.3
9.1
34
106
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.0
9.1
99
518
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
9.2
9.1
18
20
181
Kela drug reimbursment
Retigabine and vigabatrin
15.8
9.0
14
9
M35.7
ICD-10 Finland
Hypermobility syndrome
4.2
9.0
24
59
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
9.0
652
5594
H50.0
ICD-10 Finland
Convergent concomitant strabismus
4.3
9.0
23
55
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.0
295
2122
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
24.3
8.9
12
5
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.6
8.9
21
47
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
8.8
163
1012
ZXA05
NOMESCO Finland
Left side
1.8
8.7
149
903
A06AD11
ATC
lactulose; oral
2.1
8.7
83
413
R32
ICD-10 Finland
Unspecified urinary incontinence
3.8
8.7
26
70
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
8.7
183
1177
-, ,
ICD-10 Finland
4.5
8.6
21
48
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
8.6
125
721
R1250
NOMESCO Finland
Evaluation of functional capability
3.5
8.6
29
85
AAF15
NOMESCO Finland
Ventriculoatrial shunt
27.8
8.5
11
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
8.5
213
1432
R5110, ,
SPAT
2.9
8.5
39
138
A02BC02
ATC
pantoprazole; systemic
1.5
8.4
458
3664
R33
ICD-10 Finland
Retention of urine
2.8
8.4
41
150
H50.30
ICD-10 Finland
Intermittent esotropy
4.9
8.4
18
37
7410B
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG CERVIC]
+∞
8.3
8
*
74191
ICD-8 Finland
Spina bifida, Hydrocephalo non indicato, non ente tecta
+∞
8.3
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
8.2
242
1691
S06.0
ICD-10 Finland
Concussion
1.9
8.2
112
633
N06AX16
ATC
venlafaxine; oral
1.8
8.2
136
817
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
8.2
8.1
17
21
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
11.8
8.1
14
12
N03AF04
ATC
eslicarbazepine; oral
33.7
8.1
10
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
8.1
120
696
R1260
NOMESCO Finland
Evaluation of communicative skills
4.2
8.0
21
51
602
Kela drug reimbursment
Children's severe malnutrition
3.6
8.0
26
74
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.6
8.0
26
74
TJD20
NOMESCO Finland
Change of gastrostomy tube
7.3
8.0
18
25
L01
ICPC
Neck symptom/complaint
1.8
8.0
141
862
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
2.8
8.0
39
143
H50.31
ICD-10 Finland
Intermittent exotropia
3.8
7.9
24
65
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.6
7.9
25
70
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
13.2
7.9
13
10
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.2
7.9
20
33
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.8
327
2466
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.1
7.8
31
101
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
45.4
7.7
9
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.7
114
660
ZXA00
NOMESCO Finland
Right side
1.7
7.6
161
1032
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
7.6
106
602
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
18.5
7.6
11
6
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
7.6
70
344
M41.5
ICD-10 Finland
Other secondary scoliosis
25.2
7.6
10
*
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
25.2
7.6
10
*
SPAT1260
SPAT
Consultation of another employee
1.7
7.5
142
883
N03AB02
ATC
phenytoin; systemic
7.2
7.5
17
24
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.5
74
374
ZXD35
NOMESCO Finland
Usual procedure
3.3
7.4
28
88
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.8
7.4
37
137
199
Kela drug reimbursment
Rufinamide
80.7
7.4
8
*
7545B
ICD-9 Finland
Certain congenital musculoskeletal deformities, Varus deformities of feet[TALIPES EQUINOVARUS CONGENITUS]
80.7
7.4
8
*
7424A
ICD-9 Finland
Other congenital anomalies of nervous system, Other specified anomalies of brain
80.7
7.4
8
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
7.4
57
260
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
11.0
7.3
13
12
Q03.88
ICD-10 Finland
Other congenital hydrocephalus
+∞
7.3
7
*
N03AX25
ATC
cenobamate; oral
+∞
7.3
7
*
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
+∞
7.3
7
*
SPAT1153
SPAT
Removal of sutures
1.6
7.2
196
1337
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.3
7.2
53
238
N02BF01
ATC
gabapentin; oral
2.2
7.2
60
284
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
7.1
61
291
R52.2
ICD-10 Finland
Other chronic pain
2.8
7.1
34
123
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.9
7.1
14
16
ZXC40
NOMESCO Finland
Use of ultrasound
8.9
7.1
14
16
Z2221
NOMESCO Finland
Medical doctor
1.5
7.0
231
1646
9165
FHL
Removal of osteosynthesis material
4.3
7.0
18
43
101
Kela drug reimbursment
Anterior pituitary hypofunction
3.9
7.0
20
52
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
7.0
74
383
N06AA09
ATC
amitriptyline; systemic
2.2
7.0
59
280
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.0
6.9
19
48
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.9
332
2561
A03FA02
ATC
cisapride; oral, rectal
2.4
6.9
47
204
ZY010
NOMESCO Finland
Hospital outpatient
2.0
6.8
74
386
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
11.0
6.8
12
11
R55
ICD-10 Finland
Syncope and collapse
2.0
6.8
72
373
G82.1
ICD-10 Finland
Spastic paraplegia
40.4
6.8
8
*
ZXC86
NOMESCO Finland
Use of endoscopic device
16.8
6.8
10
6
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.6
6.7
22
63
KDV20
NOMESCO Finland
Submucous urethral injection
22.7
6.7
9
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.8
6.7
33
122
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
6.7
156
1026
RL140, ,
NOMESCO Finland
6.5
6.7
16
25
RT150, ,
NOMESCO Finland
5.5
6.6
18
33
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
7.9
6.6
14
18
UJF32
NOMESCO Finland
Coloscopy
1.7
6.6
144
930
M05BA04
ATC
alendronic acid; oral
2.6
6.6
37
146
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
6.6
32
117
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
12.4
6.6
11
9
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.6
688
6132
WX892
NOMESCO Finland
Monitored bed care
2.1
6.6
62
308
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
10.1
6.5
12
12
SPAT1301
SPAT
No procedures
1.5
6.5
243
1775
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.5
144
933
R5599
NOMESCO Finland
Other rehabilitation service
2.7
6.5
33
124
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
5.8
6.5
17
30
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.5
95
549
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
6.5
56
269
Z02.7
ICD-10 Finland
Issue of medical certificate
2.1
6.4
62
310
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
6.4
76
409
AB4AE
NOMESCO Finland
Spinal ultrasound examination
70.3
6.4
7
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
70.3
6.4
7
*
3431A
ICD-9 Finland
Infantile cerebral palsy, Hemiplegic
70.3
6.4
7
*
L82
ICPC
Congenital anomaly musculoskeletal
70.3
6.4
7
*
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
70.3
6.4
7
*
34532
ICD-8 Finland
Epilepsy, Partialis (focalis) generalisata
70.3
6.4
7
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
6.4
136
872
H52.2
ICD-10 Finland
Astigmatism
2.8
6.4
32
119
ZYC01
NOMESCO Finland
Remote contact by phone
2.1
6.4
61
304
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.1
6.4
26
86
R4130
NOMESCO Finland
Speech therapy
2.7
6.4
33
125
K59.09
ICD-10 Finland
Constipation, unspecified
2.2
6.4
51
237
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.1
6.4
17
42
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.6
6.4
15
23
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
5.6
6.3
17
31
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.9
6.3
29
103
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
3.9
6.3
18
47
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
18.2
6.3
9
5
Q01.9
ICD-10 Finland
Encephalocele, unspecified
+∞
6.3
6
*
M49.4*G95.0
ICD-10 Finland
Neuropathic spondylopathy in syringomyelia and syringobulbia
+∞
6.3
6
*
3360A
ICD-9 Finland
Other diseases of spinal cord, Syringomyelia and syringobulbia
+∞
6.3
6
*
Q04.4
ICD-10 Finland
Septo-optic dysplasia
+∞
6.3
6
*
G00.8
ICD-10 Finland
Other bacterial meningitis
+∞
6.3
6
*
2139
FHL
Other measure in this category
+∞
6.3
6
*
Q06.3
ICD-10 Finland
Other congenital cauda equina malformations
+∞
6.3
6
*
AAF50
NOMESCO Finland
Third ventriculostomy
26.9
6.2
8
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
26.9
6.2
8
*
ZXA10
NOMESCO Finland
Bilateral
1.7
6.2
131
838
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
6.2
71
378
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
6.2
87
496
M54.6
ICD-10 Finland
Pain in thoracic spine
2.0
6.2
66
343
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.2
373
2986
C03CA01
ATC
furosemide; systemic
1.7
6.1
115
713
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
7.7
6.1
13
17
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.1
6.1
55
268
J01FF01
ATC
clindamycin; systemic
1.6
6.1
181
1257
XX1XW
NOMESCO Finland
Extensive written report from radiologist
3.8
6.1
18
48
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.0
6.1
66
345
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
12.6
6.1
10
8
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.1
6.0
54
263
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
6.1
6.0
15
25
ZXY02
NOMESCO Finland
Neuropsychologist
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
483
3024
2.30
32.40
10.4
8.0
1.21
1.22
mmol/l
1.09
425
2644
449
2748
2.27
31.54
9.8
8.1
1.21
1.22
mmol/l
1.93
422
2556
81
205
4.25
29.26
1.8
3.2
632.08
403.43
mg/l
1.25
76
196
47
77
6.39
27.78
2.6
2.0
—
—
—
0
0
35
41
8.84
27.67
1.6
1.7
—
—
—
0
0
71
189
3.99
23.91
1.7
3.2
3.53
3.55
mmol/l
0.07
66
179
281
1555
2.18
23.82
2.5
2.1
212.46
227.53
u/l
0.07
267
1481
32
44
7.51
22.17
2.1
2.6
—
—
—
0
0
70
199
3.73
21.47
2.0
3.4
40.43
6.83
e6/l
0.94
53
144
70
199
3.73
21.47
2.0
3.5
169.11
254.99
e6/l
0.41
56
149
126
512
2.70
21.15
7.5
10.5
0.63
0.81
mmol/l
0.19
90
402
524
3787
1.93
19.88
6.5
5.5
6.00
6.32
mmol/l
4.57
500
3444
373
2430
1.92
19.23
5.1
5.3
37.43
36.97
g/l
0.96
343
2286
813
6988
2.82
18.52
17.8
11.8
139.37
139.55
mmol/l
1.20
796
6787
813
7007
2.79
18.06
17.4
11.9
3.94
3.93
mmol/l
0.33
793
6783
50
132
3.95
17.01
6.4
6.0
446.29
388.78
umol/l
1.45
45
120
322
2073
1.87
16.66
1.9
1.8
98.22
96.90
pmol/l
0.19
179
1100
407
2818
1.82
16.61
2.9
2.6
75.43
72.75
nmol/l
0.70
382
2618
270
1700
1.84
14.64
4.2
5.2
94.28
92.71
%
0.56
261
1648
337
2276
1.77
14.41
9.9
8.4
1.13
1.13
inr
0.05
97
713
603
4816
1.78
14.05
6.5
6.6
84.63
84.50
u/l
0.02
576
4532
32
71
4.64
13.62
6.5
9.4
9.96
9.53
mg/l
0.15
27
66
294
1958
1.75
12.91
2.8
2.9
2.36
2.36
mmol/l
0.03
265
1769
142
749
2.07
12.85
2.1
2.2
381.99
359.07
nmol/l
0.66
127
701
250
1611
1.77
12.20
2.5
2.3
—
—
—
0
0
118
598
2.12
11.83
5.9
5.2
—
—
—
0
0
48
159
3.13
11.62
2.0
2.5
625.90
228.02
ug/l
0.86
38
143
417
3119
1.63
11.44
5.1
6.3
12.29
13.76
umol/l
0.52
388
2940
533
4252
1.63
11.12
8.1
9.5
3.96
3.86
e9/l
0.44
477
3665
140
775
1.96
10.98
1.6
1.7
1125.13
1174.92
nmol/l
0.29
111
597
176
1057
1.83
10.73
1.4
1.5
57241833.11
37214804.01
pmol/l
0.13
145
919
829
7541
2.39
10.63
9.9
8.8
25.27
26.27
u/l
0.95
815
7305
314
2270
1.59
9.43
5.1
3.2
—
—
—
0
0
185
1168
1.74
9.42
1.6
1.4
21.52
20.89
nmol/l
0.20
161
1012
134
768
1.88
9.41
7.5
7.5
1.97
1.35
mmol/l
1.56
111
614
242
1653
1.64
9.13
2.4
2.4
2.98
2.79
mg/l
0.56
210
1437
664
5714
1.63
9.12
4.6
3.9
14.57
14.42
pmol/l
0.86
619
5285
410
3190
1.53
8.68
2.9
2.7
—
—
—
0
0
593
5001
1.55
8.57
4.2
3.8
9.35
9.26
mm/h
0.07
567
4664
200
1334
1.64
8.19
4.1
2.5
5.63
7.54
e6/l
1.46
183
1181
166
1060
1.70
8.02
4.2
2.7
1.11
0.97
e6/l
0.25
100
556
142
881
1.73
7.60
2.0
1.9
—
—
—
0
0
148
933
1.70
7.47
2.5
4.2
28.40
30.14
s
4.59
139
911
737
6617
1.65
7.42
5.3
4.5
1.72
2.00
mu/l
0.90
692
6224
256
1856
1.53
7.24
3.4
3.0
16.16
28.40
ng/l
1.89
146
954
138
861
1.71
7.23
2.0
2.4
2.42
2.42
mmol/l
0.15
118
749
145
923
1.68
7.04
9.5
8.2
1.17
1.17
mmol/l
0.01
137
879
25
76
3.36
7.01
1.0
1.2
61.98
33.67
mg/l
0.78
20
57
27
87
3.17
6.91
1.1
1.1
—
—
—
0
0
111
660
1.78
6.87
14.6
8.0
1.14
1.16
mmol/l
0.02
76
476
247
1808
1.51
6.58
5.3
3.0
0.23
0.30
e6/l
0.35
199
1325
148
966
1.64
6.51
4.9
5.9
0.82
0.82
mmol/l
0.10
139
923
215
1544
1.52
6.24
4.8
3.2
1.02
1.02
kg/l
0.34
35
221
154
1027
1.60
6.19
4.6
2.9
3.14
2.80
e6/l
0.19
90
525
249
1849
1.48
6.12
2.6
2.6
52.52
56.07
u/l
0.87
229
1726
55
268
2.12
6.12
1.4
1.2
0.24
0.92
u/ml
—
7
13
262
1969
1.47
6.05
5.5
3.1
20.86
101.91
e6/l
1.48
212
1467
246
1838
1.47
5.82
5.3
3.3
0.00
0.00
estimate
1.08
81
681
792
7356
1.68
5.67
16.6
11.0
20.45
20.69
mg/l
0.08
664
5534
21
66
3.23
5.62
1.0
1.1
—
—
—
0
0
15
29
5.24
5.41
2.3
2.4
25.25
18.20
umol/l
0.96
15
29
24
84
2.91
5.38
1.0
1.0
—
—
—
0
0
629
5590
1.42
5.37
4.6
4.3
36.66
38.05
mmol/mol
4.12
586
5271
428
3567
1.38
5.36
5.1
3.2
0.00
0.01
estimate
0.80
84
672
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
18
53
3.45
5.33
1.1
1.3
—
—
—
0
0
207
1519
1.47
5.32
1.9
2.6
0.82
1.17
mg/l
1.23
156
1108
28
108
2.64
5.26
2.2
2.5
16.68
16.66
%
0.01
16
59
424
3537
1.38
5.24
5.0
3.2
0.02
0.00
estimate
0.45
87
708
53
271
2.02
5.23
3.4
7.0
0.63
0.63
%
0.02
53
271
423
3531
1.38
5.19
6.7
4.4
0.01
0.00
estimate
0.42
80
693
101
634
1.67
5.15
2.1
1.9
—
—
—
0
0
438
3681
1.37
5.14
3.3
2.9
72.76
78.26
ug/l
0.41
415
3465
100
627
1.67
5.13
1.9
1.8
—
—
—
0
0
157
1100
1.52
5.04
3.3
3.8
1013.16
868.55
ng/l
0.28
129
901
95
593
1.67
4.95
2.5
3.2
0.21
0.22
g/l
0.40
85
563
10
13
7.76
4.86
3.6
2.9
21.80
27.07
umol/l
—
10
13
16
47
3.45
4.76
1.1
1.3
—
—
—
0
0
59
329
1.85
4.55
2.1
3.2
66.64
66.98
g/l
0.17
52
307
68
403
1.74
4.30
1.6
1.8
7.68
8.39
u/l
0.21
46
307
677
6183
1.39
4.28
3.9
3.4
5.59
5.67
mmol/l
1.02
626
5735
435
3719
1.33
4.27
6.3
6.7
54.65
54.28
%
0.24
417
3539
90
577
1.62
4.25
1.6
1.6
18.83
20.10
iu/l
0.14
69
467
328
2701
1.34
4.13
5.1
3.1
—
—
—
0
0
53
297
1.83
4.05
1.6
1.6
—
—
—
0
0
437
3761
1.32
4.00
6.6
6.9
30.92
31.20
%
0.19
419
3586
664
6082
1.36
3.84
11.0
8.9
99.41
93.23
ml/min/173m2
9.37
564
4772
29
133
2.22
3.83
2.0
2.4
137.48
132.30
g/l
0.46
21
103
32
153
2.13
3.82
1.9
1.5
—
—
—
0
0
11
25
4.44
3.63
3.1
2.9
0.98
1.04
umol/l
0.24
11
25
66
408
1.67
3.62
2.1
1.7
—
—
—
0
0
67
416
1.66
3.61
6.4
3.4
1.22
1.23
mmol/l
0.33
59
357
131
949
1.45
3.54
3.0
2.4
13.64
14.36
umol/l
0.55
122
893
21
87
2.45
3.49
2.7
3.9
—
—
—
0
0
57
909
0.60
3.45
1.5
1.6
—
—
—
0
0
32
161
2.02
3.38
1.7
1.4
—
—
—
0
0
120
868
1.44
3.27
3.1
2.4
2.48
2.45
g/l
0.27
112
805
864
8379
1.96
3.27
23.3
16.5
40.19
40.77
%
0.49
824
7991
26
510
0.50
3.23
1.6
1.5
—
—
—
0
0
110
785
1.46
3.22
3.3
2.5
21.87
23.47
%
0.63
98
697
864
8383
1.94
3.20
23.1
16.3
267.23
261.76
e9/l
1.72
855
8167
97
677
1.49
3.18
1.3
1.2
98.40
154.87
iu/ml
1.29
32
279
864
8390
1.92
3.08
23.1
16.2
4.54
4.56
e12/l
0.40
853
8154
14
51
2.77
2.99
1.0
1.1
1.25
1.07
u/l
—
6
22
284
2377
1.29
2.99
3.7
3.5
29.11
30.86
u/l
0.42
266
2263
5
5
10.05
2.98
1.2
1.4
—
—
—
0
0
79
540
1.51
2.88
2.9
2.7
—
—
—
0
0
87
610
1.47
2.81
2.1
2.4
24.55
111.69
u/l
0.56
73
506
52
325
1.64
2.78
2.3
2.2
6.73
7.27
ug/l
0.07
45
290
25
469
0.52
2.74
1.4
1.4
—
—
—
0
0
153
1201
1.33
2.56
1.3
1.3
23.99
26.33
iu/ml
0.10
56
374
29
158
1.86
2.50
2.5
2.1
0.35
3.11
ug/l
0.94
24
143
714
6739
1.30
2.50
18.5
14.0
14.46
14.01
%
1.43
707
6634
23
116
2.01
2.47
5.9
3.0
4.85
4.89
kpa
0.10
23
116
37
219
1.72
2.45
1.7
2.1
—
—
—
0
0
18
83
2.19
2.42
1.3
1.3
0.67
0.48
nmol/l
0.38
18
78
27
471
0.56
2.35
1.4
1.5
—
—
—
0
0
37
593
0.61
2.34
1.4
1.4
—
—
—
0
0
27
470
0.56
2.33
1.4
1.5
—
—
—
0
0
27
470
0.56
2.33
1.4
1.4
—
—
—
0
0
9
28
3.24
2.31
1.1
1.2
—
—
—
0
0
52
342
1.55
2.30
1.6
1.4
—
—
—
0
0
13
53
2.47
2.28
1.2
1.2
—
—
—
0
0
9
29
3.12
2.23
1.0
1.2
—
—
—
0
0
9
29
3.12
2.23
1.1
1.2
—
—
—
0
0
9
29
3.12
2.23
3.3
4.4
181.44
131.31
ug/l
—
9
29
70
495
1.45
2.20
1.4
1.6
329.14
307.90
mu/l
0.21
63
449
29
167
1.76
2.13
1.4
1.4
16.47
19.69
u/l
0.24
23
145
114
885
1.33
2.07
3.4
3.8
1.49
2.06
ug/l
0.82
105
800
5
10
5.02
2.07
1.2
1.3
—
—
—
0
0
238
2030
1.24
2.04
1.7
1.5
1.89
1.97
g/l
0.42
147
1201
104
800
1.34
2.02
2.7
3.9
4.74
6.58
umol/l
1.62
93
667
11
44
2.52
2.01
1.8
2.3
—
—
—
0
0
18
90
2.02
2.01
1.7
1.3
—
—
—
0
0
7
21
3.35
1.97
1.0
1.0
86.66
107.98
nmol/l
—
7
14
34
212
1.63
1.91
1.9
2.0
—
—
—
0
0
31
189
1.66
1.89
1.6
1.8
—
—
—
0
0
263
2283
1.22
1.89
1.3
1.5
1.03
2.37
u/ml
2.24
71
560
8
28
2.87
1.86
1.1
1.3
—
—
—
0
0
6
17
3.55
1.84
1.3
1.1
—
—
—
0
0
5
12
4.18
1.82
3.8
3.3
—
—
—
0
0
5
12
4.18
1.82
1.0
1.0
—
—
—
0
0
10
220
0.45
1.80
1.7
1.2
—
—
—
0
0
28
448
0.61
1.80
1.5
1.6
—
—
—
0
0
81
614
1.35
1.75
1.6
1.3
498.84
238.54
u/ml
0.29
73
573
60
817
0.72
1.75
1.6
1.5
—
—
—
0
0
47
324
1.48
1.73
2.7
3.7
92.87
152.19
ng/l
1.17
39
293
25
404
0.61
1.69
2.0
1.7
—
—
—
0
0
147
1214
1.25
1.68
2.3
2.6
137.15
98.25
ug/g
0.81
111
966
525
4887
1.18
1.66
3.6
3.1
42.69
36.94
u/l
0.74
496
4671
14
69
2.05
1.65
2.1
3.5
25.74
26.71
umol/l
0.16
14
69
18
99
1.84
1.58
1.8
1.5
—
—
—
0
0
206
1784
1.20
1.50
3.8
3.4
7.34
8.26
mmol/l
1.75
187
1587
7
28
2.51
1.45
2.3
1.8
—
—
—
0
0
7
28
2.51
1.45
1.4
1.3
—
—
—
0
0
7
28
2.51
1.45
1.0
1.2
—
—
—
0
0
11
52
2.13
1.45
1.5
2.7
3.95
3.99
mmol/l
0.13
11
52
11
52
2.13
1.45
1.5
2.7
105.09
106.13
mmol/l
0.36
11
52
42
295
1.44
1.44
1.3
1.3
—
—
—
0
0
7
29
2.42
1.39
1.4
1.3
—
—
—
0
0
0
38
0.00
1.34
0.0
4.6
—
—
—
0
0
24
363
0.65
1.27
1.6
1.5
—
—
—
0
0
9
44
2.06
1.27
2.7
1.7
—
—
—
0
0
166
1433
1.19
1.26
2.1
2.9
313.62
4581.55
umol/l
4.23
150
1294
117
976
1.23
1.25
3.5
3.4
245.51
614.90
ng/l
1.02
68
594
6
25
2.41
1.24
2.3
1.8
—
—
—
0
0
31
213
1.47
1.22
1.6
1.7
100.27
99.22
u/ml
0.02
11
30
17
102
1.68
1.17
2.4
3.4
598.50
551.55
e6/l
0.12
12
77
86
701
1.25
1.15
4.0
3.5
22.10
21.48
%
0.13
38
261
133
1138
1.20
1.12
1.3
1.2
9.87
9.82
u/ml
0.00
54
451
44
329
1.35
1.11
12.3
13.2
1.13
1.15
mg/l
0.14
44
315
20
128
1.58
1.09
1.0
1.2
—
—
—
0
0
41
305
1.36
1.07
1.2
1.2
—
—
—
0
0
5
22
2.28
1.03
1.6
1.3
—
—
—
0
0
5
22
2.28
1.03
1.6
1.3
—
—
—
0
0
13
75
1.74
1.03
2.2
1.8
—
—
—
0
0
74
603
1.25
1.01
3.4
3.4
31.44
31.43
%
0.00
59
438
7
35
2.01
1.00
2.4
1.7
—
—
—
0
0
21
140
1.51
0.98
1.1
2.1
—
—
—
0
0
17
108
1.59
0.97
2.4
1.8
—
—
—
0
0
23
157
1.48
0.97
1.8
1.3
—
—
—
0
0
23
157
1.48
0.97
1.8
1.3
—
—
—
0
0
13
77
1.70
0.95
2.0
8.3
5.52
6.45
mmol/l
1.40
13
63
60
481
1.27
0.95
2.3
2.2
10.63
12.03
nmol/l
0.63
55
443
666
6434
1.14
0.94
3.6
3.5
4.62
4.71
mmol/l
1.60
629
6109
6
27
2.23
0.93
2.3
1.7
—
—
—
0
0
6
27
2.23
0.93
2.3
1.9
—
—
—
0
0
6
27
2.23
0.93
2.3
1.9
—
—
—
0
0
6
28
2.15
0.91
2.3
1.9
—
—
—
0
0
20
135
1.49
0.89
2.5
2.3
—
—
—
0
0
22
312
0.70
0.89
1.1
1.1
6.81
5.96
u/ml
0.09
14
211
13
79
1.66
0.88
1.8
1.3
—
—
—
0
0
669
6475
1.13
0.87
3.9
3.8
2.82
2.85
mmol/l
0.34
630
6111
13
80
1.63
0.85
1.8
1.3
—
—
—
0
0
13
80
1.63
0.85
1.8
1.3
—
—
—
0
0
13
80
1.63
0.85
1.8
1.3
—
—
—
0
0
13
80
1.63
0.85
1.8
1.3
—
—
—
0
0
18
121
1.50
0.83
2.9
1.7
—
—
—
0
0
13
81
1.61
0.81
1.8
1.3
—
—
—
0
0
22
304
0.72
0.79
1.1
1.2
5.72
2.26
u/ml
0.31
13
200
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
34
261
1.31
0.77
1.6
1.6
—
—
—
0
0
15
219
0.68
0.74
1.8
1.6
—
—
—
0
0
5
25
2.01
0.72
8.6
6.0
—
—
—
0
0
27
203
1.34
0.71
2.5
1.9
7.41
4.93
iu/l
0.20
11
73
78
667
1.19
0.71
3.0
2.3
2919.53
4418.17
u/l
0.30
23
274
20
143
1.41
0.70
2.8
1.8
—
—
—
0
0
632
6130
1.11
0.69
3.3
3.2
1.22
1.23
mmol/l
0.09
590
5791
24
178
1.36
0.69
1.1
1.1
—
—
—
0
0
5
27
1.86
0.68
1.6
5.5
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
81.14
36.79
u/ml
—
5
27
7
43
1.63
0.67
1.0
1.1
—
—
—
0
0
7
43
1.63
0.67
1.6
1.2
—
79.29
—
0
7
48
578
0.82
0.64
1.3
1.3
—
—
—
0
0
657
6396
1.10
0.63
3.6
3.5
1.44
1.46
mmol/l
0.80
617
6052
8
49
1.64
0.62
1.3
1.1
87.50
85.63
%
—
8
49
119
1065
1.14
0.62
1.9
1.7
1.47
1.39
%
0.93
103
975
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
8
53
1.51
0.58
1.9
1.7
—
—
—
0
0
27
342
0.78
0.58
1.1
1.2
2.82
3.46
u/ml
0.14
16
226
6
35
1.72
0.57
2.3
1.8
—
—
—
0
0
6
35
1.72
0.57
2.3
1.8
—
—
—
0
0
12
81
1.49
0.57
1.4
1.7
—
—
—
0
0
6
36
1.67
0.56
1.0
1.6
3.62
4.39
nmol/l
—
6
36
24
185
1.31
0.56
1.5
1.2
34.04
11.63
u/ml
—
5
30
145
1323
1.11
0.56
3.8
3.9
5.27
22.35
mg/mmol
0.73
94
872
16
116
1.39
0.54
2.1
1.7
—
—
—
0
0
12
82
1.47
0.54
1.5
1.2
—
—
—
0
0
34
413
0.82
0.52
1.9
1.9
—
—
—
0
0
13
92
1.42
0.50
2.4
1.7
—
—
—
0
0
10
67
1.50
0.50
2.5
2.3
0.18
0.12
nmol/l
—
10
47
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
136
1.33
0.49
4.8
14.4
0.29
0.37
u/ml
—
10
79
7
109
0.64
0.48
1.0
2.0
—
—
—
0
0
27
217
1.25
0.48
1.3
1.6
—
266.67
—
0
6
23
181
1.28
0.48
1.2
1.4
362.00
347.58
ug/g
0.12
15
99
49
420
1.18
0.48
2.8
2.5
67.71
77.25
ml/min/173m2
0.81
21
165
14
102
1.38
0.47
1.6
2.4
216.84
99.00
ug/min
—
7
64
10
68
1.48
0.47
1.1
1.2
—
—
—
0
0
11
77
1.43
0.45
1.9
1.6
—
—
—
0
0
31
373
0.83
0.45
2.4
4.2
3.36
20.36
ug/l
0.79
22
290
31
256
1.22
0.45
1.7
1.6
253.89
204.20
u/ml
0.39
19
132
9
127
0.71
0.43
1.8
1.7
8.34
7.57
mmol/l
—
9
121
12
87
1.38
0.42
1.0
1.0
1.65
1.38
g/l
1.24
12
78
0
16
0.00
0.41
0.0
2.6
—
—
—
0
0
54
613
0.87
0.41
1.1
1.0
—
—
—
0
0
18
141
1.28
0.40
1.5
1.2
—
1.06
—
0
9
0
18
0.00
0.40
0.0
1.2
—
9.42
—
0
18
181
1923
0.93
0.39
2.5
2.3
—
—
—
0
0
5
36
1.39
0.38
2.4
1.3
—
—
—
0
0
24
197
1.22
0.38
3.7
1.9
—
—
—
0
0
5
37
1.35
0.37
2.2
2.4
—
1401.00
—
0
5
18
143
1.26
0.37
1.7
1.3
—
—
—
0
0
13
168
0.77
0.36
1.3
2.2
8.32
10.48
mg/l
0.72
13
153
165
1751
0.93
0.35
2.4
2.2
—
—
—
0
0
6
42
1.43
0.35
1.0
1.0
—
—
—
0
0
24
199
1.21
0.35
3.3
1.9
—
—
—
0
0
6
45
1.34
0.33
1.0
1.1
1415.00
1508.31
miu/ml
—
6
45
6
45
1.34
0.33
1.5
3.0
—
—
—
0
0
6
46
1.31
0.33
2.8
1.5
—
—
—
0
0
7
53
1.32
0.31
1.7
1.4
76.00
71.60
umol/l
—
7
53
47
525
0.89
0.30
2.3
2.5
0.51
0.68
ug/l
2.31
32
280
11
84
1.31
0.30
3.5
1.7
—
—
—
0
0
8
110
0.72
0.29
1.4
1.6
—
—
—
0
0
32
365
0.87
0.28
1.4
1.7
5.50
2.94
mg/l
0.87
23
244
8
62
1.29
0.28
1.6
1.4
—
—
—
0
0
8
63
1.27
0.28
1.0
1.1
—
—
—
0
0
26
225
1.16
0.26
1.7
1.7
44.58
38.50
nmol/l
0.42
26
220
11
138
0.79
0.25
1.1
1.1
—
—
—
0
0
21
179
1.18
0.25
1.8
1.9
—
—
—
0
0
12
148
0.81
0.24
1.2
1.3
1.80
5.22
u/ml
—
5
51
6
84
0.71
0.24
1.3
1.1
—
—
—
0
0
10
79
1.27
0.22
1.3
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
85.20
91.72
%
—
5
36
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
19
219
0.86
0.20
1.0
1.1
8.01
8.13
u/ml
0.01
11
124
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
53
491
1.08
0.19
1.7
1.8
—
—
—
0
0
16
137
1.17
0.19
4.9
3.9
3.88
4.07
e9/l
0.14
16
137
15
128
1.17
0.18
1.2
1.2
120.60
112.89
%
0.52
15
116
16
185
0.86
0.18
1.7
1.3
45.38
65.71
pmol/l
2.14
16
180
7
59
1.19
0.18
1.7
1.6
0.97
1.03
g/l
—
7
59
31
341
0.91
0.17
1.4
1.8
—
—
—
0
0
11
131
0.84
0.17
1.4
1.2
—
—
—
0
0
17
148
1.15
0.17
1.1
2.0
—
—
—
0
0
8
68
1.18
0.16
1.4
1.3
—
—
—
0
0
18
158
1.14
0.16
3.1
1.9
—
—
—
0
0
18
158
1.14
0.16
3.1
1.9
—
—
—
0
0
16
139
1.15
0.16
6.3
4.1
54.50
55.74
%
0.14
16
139
6
77
0.78
0.15
1.0
1.2
—
—
—
0
0
6
77
0.78
0.15
1.0
1.2
—
—
—
0
0
6
77
0.78
0.15
1.0
1.1
—
—
—
0
0
6
77
0.78
0.15
1.0
1.1
—
—
—
0
0
6
78
0.77
0.15
1.0
1.2
—
—
—
0
0
17
150
1.14
0.14
1.7
1.8
166.29
207.54
pmol/l
0.79
17
142
26
237
1.10
0.14
1.2
1.1
—
—
—
0
0
17
191
0.89
0.14
1.0
1.1
3.81
0.26
u/ml
—
7
79
651
6459
1.03
0.13
3.7
3.8
—
—
—
0
0
9
110
0.82
0.13
1.1
1.1
—
—
—
0
0
23
249
0.92
0.10
1.6
1.5
0.02
0.26
iu/ml
0.52
11
44
161
1574
1.03
0.10
1.6
1.5
—
—
—
0
0
5
44
1.14
0.10
2.0
2.5
309.60
747.45
u/ml
—
5
44
37
350
1.06
0.09
1.3
1.4
—
—
—
0
0
162
1587
1.03
0.09
1.6
1.7
1.30
1.38
mmol/l
0.67
147
1383
12
107
1.12
0.08
3.2
1.6
—
—
—
0
0
6
58
1.03
0.08
2.3
1.7
—
—
—
0
0
6
58
1.03
0.08
2.3
1.7
—
—
—
0
0
6
58
1.03
0.08
2.3
1.7
—
—
—
0
0
25
234
1.07
0.08
1.2
1.1
—
—
—
0
0
13
143
0.91
0.07
1.1
1.3
2.83
5.82
u/ml
—
6
56
7
84
0.83
0.07
3.0
1.6
—
—
—
0
0
9
85
1.06
0.07
1.6
1.6
—
—
—
0
0
40
417
0.96
0.06
1.3
1.3
180.48
260.83
miu/ml
0.78
19
212
14
128
1.10
0.06
3.1
3.5
32.43
27.43
mg/l
—
6
87
11
99
1.11
0.06
1.5
1.3
—
—
—
0
0
9
102
0.88
0.06
1.8
1.3
—
—
—
0
0
12
109
1.10
0.06
1.1
1.1
—
—
—
0
0
117
1191
0.98
0.05
2.2
2.0
—
—
—
0
0
241
2432
0.99
0.04
2.0
1.8
—
—
—
0
0
95
965
0.98
0.04
2.1
1.9
—
—
—
0
0
37
379
0.98
0.02
2.1
2.1
23.22
39.92
u/ml
1.09
37
362
19
197
0.96
0.01
1.0
1.1
2.44
6.74
u/ml
1.77
12
99
25
257
0.97
0.01
1.6
1.3
—
—
—
0
0
13
124
1.05
0.00
3.2
1.9
—
—
—
0
0
13
124
1.05
0.00
3.2
1.9
—
—
—
0
0
11
114
0.96
0.00
1.8
1.4
—
—
—
0
0
17
174
0.98
0.00
1.2
1.1
—
—
—
0
0
30
296
1.01
0.00
1.4
1.5
—
—
—
0
0
32
318
1.01
0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.4
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
9
94
0.96
-0.00
1.1
1.1
98.00
92.74
%
—
9
87
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
65.67
—
0
6
7
72
0.97
-0.00
1.1
1.2
—
327.50
—
0
12
9
95
0.95
-0.00
2.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
2.2
3.0
15.20
71.57
u/ml
—
5
51
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
462.60
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_NERVOUS_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_NERVOUS_SYSTEM | 2.691 [2.25, 3.23] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.139 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 4093 females with Q17_CONGEN_MALFO_NERVOUS_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_NERVOUS_SYSTEM | 3.066 [2.48, 3.79] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 242 out of 3664 males with Q17_CONGEN_MALFO_NERVOUS_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_NERVOUS_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.247% | 0.659% |
| 5 | 1.631% | 3.359% |
| 10 | 3.77% | 7.849% |
| 15 | 7.188% | 14.821% |
| 20 | 12.271% | 23.606% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_NERVOUS_SYSTEM – Congenital malformations of the nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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