No definition available.
Other congenital malformations of nervous system
Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
386 |
4. Check minimum number of eventsNone |
386 |
5. Include endpointsNone |
386 |
6. Filter based on genotype QC (FinnGen only) |
373 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q0
- Name in latin
- Aliae malformationes congenitae systematis nervosi
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of nervous system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2035 | 1322 |
| Only index persons | 2889 | 1839 | 1050 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 19.42 | 24.31 | 11.87 |
| Only index persons | 23.03 | 27.09 | 15.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 373 | 300 | 73 |
| Unadjusted period prevalence (%) | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | 32.37 | 32.57 | 31.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 386
- Matched controls
- 3860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
+∞
307.7
346
*
ABE50
NOMESCO Finland
Occipitocervical decompression
+∞
110.9
101
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.1
75.3
84
87
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.7
54.9
104
200
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
15.0
46.7
43
32
R51.80
ICD-10 Finland
Headache
4.6
46.3
167
552
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
241.2
42.8
43
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.7
41.2
90
195
Q07.8
ICD-10 Finland
Other specified congenital malformations of nervous system
+∞
34.9
33
*
N03AX12
ATC
[U] gabapentin; oral
4.7
34.7
98
262
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.4
31.0
68
146
R42
ICD-10 Finland
Dizziness and giddiness
3.7
27.4
111
380
AA1AD
NOMESCO Finland
CT of head and brain
3.7
27.0
108
366
G44.2
ICD-10 Finland
Tension-type headache
3.3
22.3
105
391
R20.2
ICD-10 Finland
Paraesthesia of skin
4.4
21.8
60
154
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
18.9
21.7
33
19
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
20.8
117
481
N03AX16
ATC
[U] pregabalin
3.2
19.9
97
366
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
22.2
17.5
25
12
N06AX21
ATC
duloxetine; oral
3.4
17.1
72
247
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
15.0
17.1
28
20
R51
ICD-10 Finland
Headache
4.1
17.0
51
139
Q07.9
ICD-10 Finland
Congenital malformation of nervous system, unspecified
+∞
16.8
16
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.4
15.6
41
101
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.2
15.0
69
249
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
14.6
77
300
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.4
13.6
52
167
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
13.5
102
478
TAB00
NOMESCO Finland
Lumbar puncture
4.3
13.2
36
91
N02AX02
ATC
tramadol; systemic, rectal
2.3
12.6
144
807
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
12.4
183
1133
N03AE01
ATC
clonazepam; systemic
4.5
12.2
31
74
N03AX11
ATC
topiramate; oral
4.8
11.8
27
59
N03AX09
ATC
lamotrigine; oral
3.5
11.5
42
131
A02BC02
ATC
pantoprazole; systemic
2.1
11.2
228
1574
L01
ICPC
Neck symptom/complaint
2.4
10.7
86
411
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
113.0
10.5
11
*
N02BF01
ATC
gabapentin; oral
3.4
10.3
39
124
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.2
9.9
41
138
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
9.8
63
270
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
9.7
108
588
N06AX16
ATC
venlafaxine; oral
2.4
9.5
76
360
M54.5
ICD-10 Finland
Low back pain
2.0
9.5
148
914
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
9.5
47
176
L28
ICPC
Limited function/disability (L)
2.7
9.4
53
212
N03AX14
ATC
levetiracetam; systemic
5.2
9.2
19
38
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
9.1
78
382
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
9.0
78
383
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
9.0
31
93
G47.3
ICD-10 Finland
Sleep apnoea
2.4
8.9
70
329
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
8.7
33
105
R52.2
ICD-10 Finland
Other chronic pain
4.7
8.7
20
44
M03BX02
ATC
tizanidine; oral
1.9
8.6
229
1673
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
8.6
35
117
SPAT1310
SPAT
Counselling related to known health issue
1.9
8.5
145
915
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
11.1
8.4
15
14
WX402
NOMESCO Finland
General anaesthesia
2.1
8.3
96
527
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
8.3
83
432
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.4
8.3
30
93
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.9
8.2
18
38
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.3
8.1
31
99
N03AF02
ATC
oxcarbazepine; oral
3.8
8.1
25
69
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.3
8.1
21
51
M03BX01
ATC
baclofen; systemic
7.5
8.1
18
25
M35.7
ICD-10 Finland
Hypermobility syndrome
6.8
8.0
19
29
XKD00
NOMESCO Finland
Uroflowmetry
3.2
7.9
32
106
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
3.9
7.9
23
61
A02BC01
ATC
omeprazole; systemic
2.0
7.8
99
562
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
45.9
7.7
9
*
A01
ICPC
Pain general/multiple sites
2.7
7.7
43
171
SPAT1301
SPAT
No procedures
1.9
7.5
127
795
R96
ICPC
Asthma
2.7
7.5
42
168
M54
ICD-10 Finland
Dorsalgia
2.3
7.4
62
299
SPAT1153
SPAT
Removal of sutures
2.0
7.4
98
565
UKC02
NOMESCO Finland
Cystoscopy
2.9
7.3
35
128
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
7.3
50
220
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.4
7.3
18
42
N99
ICPC
Neurological disease other
20.5
7.2
10
5
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
20.5
7.2
10
5
M79.7
ICD-10 Finland
Fibromyalgia
3.8
7.1
22
61
N06AA09
ATC
amitriptyline; systemic
3.0
7.1
31
108
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
3.1
7.0
30
103
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.0
7.0
89
504
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.1
7.0
19
48
R11
ICD-10 Finland
Nausea and vomiting
2.4
7.0
50
225
A02BC05
ATC
esomeprazole; systemic
1.8
7.0
130
836
SPAT1216
SPAT
Assessment of functional ability
2.5
7.0
45
193
UJF32
NOMESCO Finland
Coloscopy
2.1
6.9
71
371
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
6.9
55
259
G47.9
ICD-10 Finland
Sleep disorder, unspecified
4.0
6.8
19
49
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
7.4
6.8
15
21
M79.6
ICD-10 Finland
Pain in limb
1.8
6.7
159
1096
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.7
6.7
21
59
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.5
6.7
43
184
WX882
NOMESCO Finland
High dependency care
3.4
6.7
24
74
C09CA06
ATC
candesartan; oral
2.1
6.6
73
392
N02BE01
ATC
paracetamol; systemic, rectal
2.1
6.6
321
2726
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
6.6
45
198
G43.9
ICD-10 Finland
Migraine, unspecified
2.3
6.6
50
231
G44.8
ICD-10 Finland
Other specified headache syndromes
6.4
6.5
16
26
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
71.0
6.4
7
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.2
6.4
58
288
ZYC01
NOMESCO Finland
Remote contact by phone
2.7
6.4
34
132
H53.2
ICD-10 Finland
Diplopia
5.3
6.4
18
35
N01
ICPC
Headache
1.9
6.4
94
558
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
11.3
6.3
11
10
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.3
105
649
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
6.3
80
452
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.5
6.2
21
62
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.5
6.2
21
62
R4120
NOMESCO Finland
Occupational therapy
2.6
6.2
35
140
M54.6
ICD-10 Finland
Pain in thoracic spine
2.6
6.2
35
140
SPAT1263
SPAT
Sampling
1.7
6.2
172
1232
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
6.2
124
810
SPAT1097
SPAT
Recording of ECG
2.5
6.2
38
159
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.2
127
836
G43.3
ICD-10 Finland
Complicated migraine
3.9
6.2
18
48
A02BC03
ATC
lansoprazole; oral
1.9
6.1
80
457
N05BA04
ATC
oxazepam; oral
1.8
6.1
100
615
A04
ICPC
Weakness/tiredness general
2.0
6.0
72
398
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
219
1232
2.80
21.72
9.2
6.2
1.21
1.22
mmol/l
1.04
194
1071
204
1126
2.72
20.70
8.9
5.9
1.22
1.22
mmol/l
0.86
189
1055
36
78
4.99
15.99
2.1
2.3
137.82
222.59
e6/l
0.30
28
64
36
78
4.99
15.99
2.1
2.3
76.52
6.52
e6/l
1.03
27
60
131
651
2.53
15.55
2.3
2.1
237.19
268.20
u/l
0.07
124
624
244
1602
2.42
15.44
6.4
4.3
5.95
6.26
mmol/l
2.31
232
1429
56
187
3.33
13.79
7.2
7.7
0.91
0.96
mmol/l
0.03
39
144
288
2094
2.48
13.64
6.2
6.3
75.09
78.42
u/l
0.60
274
1964
363
3012
4.44
12.74
15.9
9.8
3.93
3.91
mmol/l
0.75
356
2902
362
3012
4.25
12.34
16.1
9.8
139.59
139.55
mmol/l
0.14
355
2914
154
909
2.15
11.61
5.8
7.7
1.04
1.09
inr
0.77
46
316
23
26
9.33
11.42
2.8
1.4
—
—
—
0
0
160
980
2.08
10.77
4.3
4.8
38.05
37.28
g/l
1.31
146
929
324
2598
2.54
10.59
5.1
4.1
14.38
14.35
pmol/l
0.09
304
2403
18
15
12.52
10.45
1.1
1.7
—
—
—
0
0
147
893
2.04
9.95
2.1
1.7
97.97
98.09
pmol/l
0.01
89
465
286
2217
2.12
9.50
4.3
3.7
8.36
8.81
mm/h
0.30
271
2067
127
747
2.04
9.28
3.2
2.8
17.73
23.29
ng/l
0.29
61
341
194
1325
1.93
9.17
5.4
5.7
10.13
11.18
umol/l
0.32
180
1240
350
2970
2.91
9.15
5.8
4.7
1.64
1.78
mu/l
2.26
333
2793
15
12
12.95
8.94
1.4
1.7
—
—
—
0
0
53
220
2.63
8.77
13.2
8.1
24.28
24.91
mmol/l
0.68
53
220
84
434
2.20
8.54
1.4
1.5
120290305.65
21503025.10
pmol/l
0.38
69
386
67
319
2.33
8.26
1.9
2.1
384.26
383.59
nmol/l
0.01
58
299
22
56
4.11
7.99
2.1
1.9
806.43
186.90
ug/l
0.59
14
47
180
1255
1.81
7.51
2.8
2.5
72.91
71.54
nmol/l
0.26
168
1156
368
3280
3.62
7.43
10.1
8.2
23.15
24.65
u/l
1.13
363
3172
118
733
1.88
7.06
2.3
2.1
2.95
2.79
mg/l
0.36
100
631
124
784
1.86
7.01
3.1
2.4
51.24
58.75
u/l
1.52
113
731
48
215
2.41
6.76
11.5
5.4
1.33
1.23
mmol/l
0.09
32
151
75
411
2.02
6.43
3.5
3.5
498.68
690.76
ng/l
0.50
58
330
104
638
1.86
6.39
1.8
2.2
0.82
0.96
mg/l
0.29
70
452
290
2412
1.81
5.95
4.2
4.0
36.63
37.42
mmol/mol
0.90
270
2284
129
861
1.75
5.93
2.0
2.8
2.35
2.35
mmol/l
0.04
116
781
85
500
1.90
5.91
1.6
1.3
19.03
20.47
nmol/l
0.41
74
433
112
724
1.77
5.73
2.7
2.0
—
—
—
0
0
50
246
2.19
5.66
5.0
5.0
—
—
—
0
0
315
2707
1.89
5.56
3.8
3.2
5.58
5.57
mmol/l
0.03
295
2521
232
1844
1.65
5.31
8.5
8.5
3.79
3.94
e9/l
0.46
207
1591
62
340
1.98
5.27
1.7
1.5
1021.72
1124.67
nmol/l
0.46
51
267
356
3229
2.32
4.88
15.6
10.0
15.92
19.68
mg/l
2.04
305
2418
24
90
2.78
4.84
5.9
4.0
0.53
0.66
%
1.06
24
90
51
269
2.03
4.83
8.5
5.4
2.07
1.48
mmol/l
0.73
43
207
134
949
1.63
4.75
4.1
3.0
—
—
—
0
0
13
26
5.14
4.67
1.0
1.2
—
—
—
0
0
136
979
1.60
4.46
4.1
3.2
27.30
28.30
u/l
0.27
128
934
15
37
4.18
4.45
1.1
1.1
—
—
—
0
0
44
229
2.04
4.32
2.1
3.0
0.21
0.23
g/l
0.86
37
222
14
41
3.51
4.22
1.6
3.0
15.76
16.37
%
—
9
18
63
376
1.81
4.13
1.8
2.2
2.40
2.41
mmol/l
0.22
55
326
14
36
4.00
4.03
1.0
1.1
—
—
—
0
0
216
1754
1.53
4.01
3.4
2.8
68.14
64.12
ug/l
0.16
208
1642
86
568
1.66
3.93
1.3
1.3
16.09
25.10
iu/ml
1.06
28
169
30
140
2.24
3.88
16.8
6.3
9.78
9.26
kpa
0.67
30
135
99
680
1.61
3.87
4.4
3.1
1.02
1.02
kg/l
0.25
16
95
116
831
1.57
3.79
4.8
3.3
0.00
0.00
estimate
0.50
44
325
186
1481
1.49
3.69
3.0
2.5
—
—
—
0
0
198
1597
1.49
3.68
6.5
5.8
53.67
55.06
%
0.88
188
1510
16
57
2.89
3.56
2.2
1.6
—
—
—
0
0
138
1040
1.51
3.54
1.4
1.4
0.87
2.00
u/ml
1.24
38
258
49
284
1.83
3.53
1.4
1.7
18.93
19.15
iu/l
0.02
41
234
55
331
1.77
3.50
1.3
1.3
112.22
158.74
iu/ml
0.61
20
135
251
2141
1.49
3.43
3.7
2.9
32.99
33.06
u/l
0.01
240
2048
153
1186
1.48
3.39
4.8
3.1
—
—
—
0
0
303
2693
1.58
3.38
10.6
8.2
100.08
96.20
ml/min/173m2
2.66
259
2108
197
1614
1.45
3.23
6.8
6.0
31.73
30.99
%
0.42
186
1531
58
364
1.70
3.19
1.8
1.8
—
—
—
0
0
190
1556
1.44
3.07
4.6
3.1
0.04
0.00
estimate
0.49
46
337
25
121
2.14
3.00
3.0
2.9
116.65
124.75
ng/l
0.06
20
110
45
268
1.77
2.98
2.0
2.4
24.34
31.96
u/l
1.23
38
220
84
588
1.55
2.98
1.9
2.8
296.58
4015.60
umol/l
1.82
76
527
31
164
1.97
2.95
3.5
4.2
1.23
1.22
mmol/l
0.49
25
141
190
1583
1.39
2.66
4.7
3.1
0.00
0.00
estimate
-0.00
45
315
65
442
1.57
2.61
3.3
2.7
1.07
0.88
e6/l
0.25
39
239
7
15
4.73
2.61
1.0
1.2
—
—
—
0
0
9
25
3.66
2.59
7.0
4.8
1.79
1.84
ug/l
—
9
25
11
36
3.11
2.58
10.5
5.3
70.91
63.64
%
0.56
11
36
14
56
2.56
2.56
2.1
1.3
—
—
—
0
0
187
1562
1.38
2.54
6.3
4.4
0.00
0.00
estimate
0.50
40
330
308
2810
1.48
2.44
3.8
3.5
2.81
2.81
mmol/l
0.02
290
2657
40
245
1.71
2.43
1.6
1.7
—
—
—
0
0
101
765
1.43
2.41
4.4
2.9
0.34
0.34
e6/l
0.01
80
570
316
2910
1.47
2.26
4.0
4.0
—
—
—
0
0
9
29
3.15
2.24
1.8
4.0
—
—
—
0
0
5
9
5.61
2.22
2.6
2.8
55.00
55.11
nmol/l
—
5
9
61
425
1.52
2.21
3.6
2.8
4.91
3.35
e6/l
0.54
36
223
39
246
1.65
2.14
1.5
1.6
—
—
—
0
0
63
446
1.49
2.12
2.1
1.6
1.32
1.33
%
0.06
56
405
14
62
2.31
2.10
1.1
1.6
—
—
—
0
0
76
563
1.44
2.03
1.3
1.3
4.59
11.00
u/ml
1.03
28
222
42
275
1.59
2.00
1.5
1.2
137.59
264.94
u/ml
0.64
37
250
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
21
3.37
1.97
1.0
1.1
—
—
—
0
0
303
2792
1.40
1.95
3.5
3.3
4.64
4.67
mmol/l
0.25
287
2657
290
2660
1.36
1.87
3.2
3.0
1.16
1.18
mmol/l
0.21
272
2508
54
381
1.49
1.85
2.5
2.4
4134.95
3321.34
u/l
0.09
15
162
6
17
3.57
1.84
2.0
2.8
1.37
2.71
nmol/l
—
6
17
140
1168
1.31
1.76
2.1
1.7
—
—
—
0
0
300
2779
1.36
1.72
3.4
3.2
1.49
1.49
mmol/l
0.03
282
2631
23
134
1.76
1.70
1.8
1.4
—
—
—
0
0
20
113
1.81
1.64
1.6
2.0
—
—
—
0
0
6
20
3.03
1.58
2.7
1.5
—
—
—
0
0
55
404
1.42
1.55
3.4
2.9
45.93
366.40
ng/l
2.87
28
219
5
15
3.36
1.53
1.8
1.2
—
—
—
0
0
19
110
1.76
1.45
1.2
1.5
—
—
—
0
0
12
59
2.07
1.45
11.5
4.0
1.66
1.43
%
0.37
12
54
26
165
1.62
1.44
1.8
1.5
—
—
—
0
0
20
323
0.60
1.44
1.5
1.5
—
—
—
0
0
30
199
1.55
1.40
1.3
1.8
7.84
9.41
u/l
0.33
22
156
5
17
2.97
1.36
1.0
1.1
1562.80
1671.12
miu/ml
—
5
17
8
34
2.38
1.30
1.9
1.4
—
—
—
0
0
8
34
2.38
1.30
1.9
1.4
—
—
—
0
0
8
35
2.31
1.27
1.9
1.4
—
—
—
0
0
8
35
2.31
1.27
1.9
1.4
—
—
—
0
0
8
35
2.31
1.27
1.9
1.4
—
—
—
0
0
8
35
2.31
1.27
1.9
1.4
—
—
—
0
0
15
85
1.80
1.24
1.8
1.6
89.00
120.18
u/ml
—
7
15
8
38
2.13
1.19
2.1
1.6
—
—
—
0
0
39
288
1.39
1.10
1.5
1.7
—
—
—
0
0
68
549
1.29
1.08
1.7
1.8
—
—
—
0
0
20
129
1.58
1.08
1.3
1.4
—
—
—
0
0
7
33
2.14
1.06
1.7
1.4
—
—
—
0
0
37
274
1.39
1.04
3.0
3.3
32.80
31.47
%
0.35
30
195
5
22
2.29
1.03
1.4
1.7
0.77
1.01
g/l
—
5
22
7
35
2.02
1.00
2.4
1.5
—
—
—
0
0
20
294
0.66
1.00
1.4
1.4
—
—
—
0
0
27
374
0.70
0.99
1.4
1.4
—
—
—
0
0
44
563
0.75
0.99
1.5
1.5
—
—
—
0
0
17
108
1.60
0.98
1.8
2.0
9.61
6.38
iu/l
—
7
36
0
29
0.00
0.98
0.0
1.4
—
—
—
0
0
11
62
1.80
0.95
1.6
1.3
—
—
—
0
0
11
63
1.77
0.91
1.5
1.3
—
—
—
0
0
11
63
1.77
0.91
1.5
1.3
—
—
—
0
0
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
14
87
1.63
0.88
1.1
1.1
—
—
—
0
0
19
274
0.68
0.88
1.4
1.6
—
—
—
0
0
21
295
0.70
0.85
1.4
1.4
—
—
—
0
0
21
294
0.70
0.84
1.4
1.4
—
—
—
0
0
21
294
0.70
0.84
1.4
1.4
—
—
—
0
0
8
46
1.75
0.83
1.5
2.1
—
—
—
0
0
6
33
1.83
0.79
1.5
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.7
—
—
—
0
0
6
34
1.78
0.76
1.8
1.4
—
—
—
0
0
18
124
1.47
0.76
3.8
2.0
0.13
0.11
e6/l
0.10
18
118
0
28
0.00
0.76
0.0
1.4
—
—
—
0
0
19
133
1.45
0.75
1.3
1.2
—
—
—
0
0
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
5
25
2.01
0.73
1.4
1.1
—
—
—
0
0
9
56
1.62
0.73
3.2
1.7
—
—
—
0
0
11
68
1.64
0.72
1.0
1.2
—
—
—
0
0
79
681
1.20
0.72
2.0
1.9
—
—
—
0
0
23
170
1.38
0.69
6.0
3.9
21.38
21.41
%
—
10
62
5
28
1.80
0.66
1.4
1.6
—
—
—
0
0
12
78
1.56
0.66
2.3
2.0
—
—
—
0
0
15
103
1.47
0.66
2.0
2.0
—
—
—
0
0
36
288
1.28
0.65
1.1
1.1
—
—
—
0
0
16
112
1.45
0.64
1.8
1.6
—
—
—
0
0
14
96
1.48
0.62
1.4
1.9
—
—
—
0
0
8
51
1.58
0.61
2.0
1.7
12.86
13.17
%
—
8
51
6
36
1.68
0.57
1.8
1.1
—
—
—
0
0
15
108
1.40
0.54
1.8
1.6
242.67
216.00
u/ml
—
9
61
6
39
1.55
0.53
2.0
1.3
170.67
200.51
pmol/l
—
6
39
30
242
1.26
0.53
3.6
3.6
4.59
4.82
pmol/l
0.56
30
215
58
504
1.18
0.50
4.0
4.1
4.24
14.52
mg/mmol
1.99
36
330
27
220
1.24
0.45
2.8
2.5
—
—
—
0
0
15
114
1.33
0.41
15.0
11.1
1.15
1.15
mg/l
0.02
15
109
0
15
0.00
0.41
0.0
4.1
—
—
—
0
0
0
15
0.00
0.41
0.0
4.1
—
—
—
0
0
0
16
0.00
0.41
0.0
3.6
—
—
—
0
0
5
34
1.48
0.40
2.8
1.9
—
—
—
0
0
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
5
34
1.48
0.40
2.0
2.3
1433.60
701.21
e6/l
—
5
34
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
18
0.00
0.40
0.0
1.0
—
134.78
—
0
18
0
18
0.00
0.40
0.0
1.0
—
100.70
—
0
10
0
19
0.00
0.39
0.0
1.0
—
94.82
—
0
11
17
214
0.78
0.39
1.6
1.5
—
—
—
0
0
13
98
1.34
0.38
1.6
1.7
0.03
0.02
iu/ml
—
8
13
9
70
1.29
0.37
1.7
1.2
—
—
—
0
0
6
43
1.40
0.35
1.0
1.5
—
—
—
0
0
6
43
1.40
0.35
1.3
1.5
—
—
—
0
0
10
74
1.36
0.32
3.5
1.7
—
—
—
0
0
25
211
1.20
0.32
1.4
1.4
237.15
259.43
miu/ml
0.11
13
104
10
75
1.34
0.30
2.7
1.6
—
—
—
0
0
7
55
1.28
0.30
3.4
1.7
0.45
6.79
ug/l
—
7
50
20
237
0.84
0.28
2.1
1.7
—
—
—
0
0
22
187
1.19
0.27
1.4
1.4
—
—
—
0
0
13
160
0.81
0.26
2.2
2.0
—
—
—
0
0
9
75
1.20
0.25
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
14
116
1.21
0.22
1.4
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
26.22
—
0
10
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
3.28
—
0
14
6
50
1.20
0.20
1.5
1.3
—
—
—
0
0
17
196
0.86
0.19
2.1
2.1
16.25
47.28
u/ml
1.56
17
187
7
60
1.17
0.18
2.6
1.8
—
—
—
0
0
7
60
1.17
0.18
2.6
1.8
—
—
—
0
0
7
61
1.15
0.17
3.6
4.1
55.71
56.26
%
—
7
61
73
695
1.06
0.15
1.5
1.6
1.32
1.34
mmol/l
0.08
64
615
15
131
1.15
0.14
1.8
1.3
—
—
—
0
0
108
1044
1.05
0.13
2.7
2.4
—
—
—
0
0
99
959
1.04
0.11
2.7
2.2
—
—
—
0
0
13
115
1.13
0.10
1.4
1.2
—
—
—
0
0
5
45
1.11
0.10
1.0
2.8
—
—
—
0
0
5
45
1.11
0.10
2.8
1.7
—
—
—
0
0
5
46
1.09
0.09
1.4
1.5
—
—
—
0
0
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
12
133
0.90
0.08
1.8
1.5
—
—
—
0
0
27
281
0.96
0.04
1.5
1.3
—
—
—
0
0
14
131
1.07
0.03
2.9
2.5
0.54
0.71
ug/l
—
9
70
16
151
1.06
0.03
1.4
1.7
—
—
—
0
0
16
169
0.94
0.03
1.5
1.7
2.98
2.83
mg/l
0.05
11
114
16
152
1.05
0.02
1.4
1.5
—
—
—
0
0
36
368
0.98
0.01
1.6
1.4
—
—
—
0
0
87
862
1.01
0.01
1.8
1.4
—
—
—
0
0
14
146
0.96
0.00
1.0
1.1
—
6.15
—
0
18
15
148
1.01
0.00
1.3
1.5
—
—
—
0
0
18
175
1.03
0.00
4.5
2.5
55.17
81.51
ml/min/173m2
—
6
65
0
9
0.00
0.00
0.0
1.1
—
81.89
—
0
9
0
9
0.00
0.00
0.0
1.1
—
30.22
—
0
9
5
53
0.94
-0.00
1.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.44
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
65
0.92
-0.00
1.0
2.3
1.48
0.86
nmol/l
—
6
59
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 1.466 [1.11, 1.94] | 0.008 |
| Birth year | 1.002 [0.99, 1.01] | 0.727 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 1703 females with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 2.062 [1.43, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1152 males with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.435% |
| 5 | 1.029% | 2.466% |
| 10 | 2.689% | 5.886% |
| 15 | 4.951% | 11.231% |
| 20 | 8.946% | 18.364% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM – Other congenital malformations of nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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