Actinomycosis

AB1_ACTINOMYCOSIS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A42 Hospital discharge: ICD-9 — 03[9] Hospital discharge: ICD-8 — 113 Cause of death: ICD-10 — A42 Cause of death: ICD-9 — 03[9] Cause of death: ICD-8 — 113 2 out of 7 registries used, show all original rules.	143
4. Check minimum number of events None	143
5. Include endpoints None	143
6. Filter based on genotype QC (FinnGen only)	132

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_ACTINOMYCOSIS
CONTROL_EXCLUDE	AB1_OTHER_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A42
HD_ICD_9	03[9]
HD_ICD_8	113
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A42
COD_ICD_9	03[9]
COD_ICD_8	113
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Actinomycosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1062	550	497
Only index persons	861	471	390
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	55.29	54.14	56.58
Only index persons	53.82	51.92	56.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	132	62	70
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	56.74	52.62	60.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
143: Matched controls
1430

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A42.8

ICD-10 Finland

Other forms of actinomycosis

+∞

34.8

A42.0

ICD-10 Finland

Pulmonary actinomycosis

+∞

30.3

A49.9

ICD-10 Finland

Bacterial infection, unspecified

52.9

28.2

A42.9

ICD-10 Finland

Actinomycosis, unspecified

+∞

28.0

A42.2

ICD-10 Finland

Cervicofacial actinomycosis

+∞

18.1

UGC12

NOMESCO Finland

Flexible bronchoscopy

6.7

15.3

A41.9

ICD-10 Finland

Sepsis, unspecified

+∞

14.8

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

5.5

13.9

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

+∞

13.8

A42.7

ICD-10 Finland

Actinomycotic sepsis

+∞

11.6

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

+∞

10.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.9

9.9

111

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.3

9.8

207

K05.31

ICD-10 Finland

Periodontitis pronounced

4.3

8.9

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

5.1

8.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

8.7

392

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.2

8.6

JN4BD

NOMESCO Finland

Extensive body CT

4.3

7.9

NF1AA

NOMESCO Finland

Hip X-ray examination

4.6

7.5

TGC00

NOMESCO Finland

Bronchial lavation

14.4

7.5

11399

ICD-8 Finland

Actinomycosis

+∞

7.3

M04AA01

ATC

allopurinol; systemic

3.5

6.9

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.5

6.7

363

TLC02

NOMESCO Finland

Simple extraction of IUD

9.4

6.7

C03CA01

ATC

furosemide; systemic

2.6

6.7

256

GD1AD

NOMESCO Finland

Thorax CT examination

6.5

A06AD11

ATC

lactulose; oral

3.2

6.4

100

TLC00

NOMESCO Finland

Insertion of intrauterine device

6.8

6.4

WZC10

NOMESCO Finland

Written specialist consultation based on a referral from a dentist or a physician

6.8

6.4

GD1UN

NOMESCO Finland

Lung circulation SPECT

+∞

6.3

A42.1

ICD-10 Finland

Abdominal actinomycosis

+∞

6.3

GD2SN

NOMESCO Finland

Lung ventilation SPECT

+∞

6.3

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

9.2

6.2

EBA15

NOMESCO Finland

Extraction of multiple teeth

9.2

6.2

R50.9

ICD-10 Finland

Fever, unspecified

3.3

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

14.21

16.44

3.0

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.37

12.53

1.4

2.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

127

3.98

11.36

2.6

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.20

10.98

2.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

121

3.78

9.98

4.2

1.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

5.08

9.96

2.5

1.4

1.01

1.23

g/l

0.47

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

11.88

9.58

1.9

1.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

428

2.81

8.48

8.0

3.4

33.24

36.06

g/l

2.67

396

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

9.85

8.29

1.9

1.3

—

(3023368) Bacteria identified in Blood by Culture

213

2.98

8.20

8.4

3.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

9.33

8.06

1.7

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

11.79

7.99

1.9

1.2

—

(3023520) Reticulocytes [#/volume] in Blood

3.83

7.52

2.2

2.5

62.03

66.15

e9/l

0.34

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.58

7.50

1.5

—

(3022313) Gas panel - Capillary blood

6.09

7.22

9.6

1.7

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

12.96

7.22

1.3

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

105

3.35

7.16

2.2

1.5

—

(3000494) Fungus identified in Specimen by Culture

131

3.09

6.92

2.1

1.4

—

(3042631) Mycobacterium sp identified in Specimen

17.76

6.85

2.6

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

590

2.57

6.75

16.4

7.9

4.18

3.92

e9/l

0.62

524

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.31

6.47

1.5

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

106

3.18

6.43

2.4

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

476

2.41

6.20

13.6

4.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

10.71

6.15

1.2

1.3

—

(3001604) Monocytes [#/volume] in Blood

504

2.40

6.15

13.5

4.6

0.62

0.57

e9/l

1.03

447

(3006315) Basophils [#/volume] in Blood

505

2.39

6.11

13.4

4.6

0.04

e9/l

0.73

446

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

8.62

5.97

1.5

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

9.82

5.90

1.9

1.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

9.82

5.90

1.9

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

9.82

5.90

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

11.83

5.89

1.9

1.6

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

144

2.79

5.79

6.1

2.5

0.81

0.82

mmol/l

0.33

133

(3019198) Lymphocytes [#/volume] in Blood

523

2.33

5.75

14.0

4.7

1.77

1.95

e9/l

0.78

473

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

533

2.33

5.72

11.8

5.1

10.86

10.90

umol/l

0.01

494

(40760888) Immunoglobulin light chains.free panel - Serum

7.59

5.56

1.3

6.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

134

2.79

5.55

2.0

1.5

—

(3023419) Bacteria identified in Sputum by Culture

9.67

5.38

3.9

2.9

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

11.90

5.37

2.1

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

11.90

5.37

2.1

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

11.90

5.37

2.1

1.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

11.90

5.37

1.2

1.1

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

+∞

5.23

3.6

0.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.44

5.13

1.6

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

316

2.27

5.12

4.0

1.9

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

10.57

5.10

2.0

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

471

2.18

5.00

14.2

5.4

1.22

mmol/l

0.18

399

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

385

2.20

4.98

5.9

3.6

32.48

52.55

ng/l

0.86

276

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.91

4.87

1.2

1.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

9.51

4.86

1.2

1.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

10.50

4.58

1.4

1.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.00

4.50

1.2

1.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

107

808

2.29

4.47

16.3

6.1

94.36

76.62

u/l

0.68

741

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

5.36

4.43

1.6

1.5

0.25

0.31

u/ml

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

240

2.20

4.26

3.9

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.66

4.25

4.1

1.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

484

2.04

4.22

14.1

12.8

1.36

1.29

inr

0.14

133

(3014576) Chloride [Moles/volume] in Serum or Plasma

106

2.65

4.19

10.5

6.9

103.80

103.68

mmol/l

0.05

106

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.59

4.16

1.5

2.4

—

(40758558) Short blood count panel - Blood

252

2.15

4.06

9.8

6.1

—

(3037756) Immunofixation for Serum or Plasma

5.89

4.05

1.3

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

156

2.35

4.01

2.2

2.0

—

(4062490) Immunoglobulin typing, IgG

9.12

3.81

1.6

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

9.12

3.81

5.7

1.9

—

(3000991) Gas panel - Venous blood

2.88

3.73

8.0

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

6.99

3.72

8.6

2.5

25.15

25.88

mmol/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.27

3.69

3.1

1.7

—

(3025159) Blasts/100 leukocytes in Blood

2.84

3.63

6.5

3.3

0.00

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

8.10

3.60

1.6

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

297

1.99

3.51

5.0

3.1

999.37

1088.61

ng/l

0.14

242

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

318

1.94

3.35

3.6

3.1

36.76

29.55

u/l

0.76

305

(3019225) pH of Specimen

2.57

3.33

13.6

3.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

191

2.10

3.31

3.2

1.4

2.95

2.68

g/l

0.24

118

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

199

2.08

3.30

1.7

1.54

0.91

mg/l

0.66

156

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

133

2.27

3.28

1.5

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

397

1.88

3.28

2.1

1.8

92.07

96.78

pmol/l

0.37

204

(3021440) Promyelocytes/100 leukocytes in Blood

2.68

3.28

6.9

3.2

0.00

0.19

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.74

3.26

6.9

3.3

0.78

0.29

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

2.54

3.25

1.6

2.3

6.82

6.91

ug/l

0.01

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.15

3.23

2.2

1.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.64

3.19

6.1

6.7

1.16

1.39

mmol/l

0.45

(4035726) Immunohistochemistry procedure

2.51

3.18

1.7

1.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

101

794

1.93

3.15

7.0

3.6

19.95

10.51

mm/h

4.25

722

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

473

1.83

3.14

3.9

2.2

—

(40768804) Tissue Pathology biopsy report

439

1.83

3.08

2.4

2.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

10.29

3.00

1.6

1.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

10.29

3.00

1.4

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.88

2.99

1.4

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.92

2.96

1.8

1.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.53

2.96

3.9

1.9

487.11

375.94

nmol/l

0.75

(3017181) Myelocytes/100 leukocytes in Blood

2.53

2.96

6.9

3.2

0.80

0.60

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

5.60

2.90

1.7

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

6.90

2.89

1.0

4.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

3.18

2.77

1.2

2.1

38.25

41.95

u/l

0.23

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

8.57

2.77

1.8

1.0

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.20

2.76

5.1

2.6

64.57

54.64

—

(3028626) Oxygen [Partial pressure] in Capillary blood

5.20

2.76

9.1

2.1

9.06

8.48

kpa

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

5.20

2.76

5.0

2.5

4.73

4.14

e9/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.39

2.72

2.8

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

255

1.85

2.64

3.5

2.5

326.94

9127.22

umol/l

1.73

220

(3003327) Ova and parasites identified in Stool by Light microscopy

3.77

2.62

1.6

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.17

2.61

1.5

2.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.64

2.57

2.5

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.64

2.57

2.5

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.64

2.57

2.5

1.1

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

7.35

2.57

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

7.35

2.57

3.2

2.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

434

1.71

2.47

3.5

2.4

268.44

101.72

ug/l

1.93

398

(3013512) EKG study

286

1.78

2.44

5.4

3.6

—

(3026008) Bacteria identified in Urine by Culture

281

1.76

2.33

4.0

2.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.62

2.30

1.0

1.1

—

(21494434) Karyotype in Bone marrow

5.71

2.23

1.0

—

(40768795) Lymph node Pathology biopsy report

5.71

2.23

1.4

1.0

—

(3021901) Oxygen saturation in Capillary blood

5.71

2.23

6.4

2.6

—

(3021788) Differential panel - Synovial fluid

5.71

2.23

1.6

1.2

—

(3021589) Normoblasts [#/volume] in Blood

465

1.63

2.15

15.9

7.8

0.00

e9/l

1.04

391

(3035637) Corticotropin [Mass/volume] in Plasma

5.14

2.09

1.4

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.53

2.09

9.8

5.5

27.27

24.86

mmol/l

0.92

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

3.62

2.08

2.1

1.7

84.14

145.87

ug/l

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

343

1.65

2.04

4.9

2.8

2.34

2.37

mmol/l

0.42

307

(3013826) Glucose [Moles/volume] in Serum or Plasma

615

1.59

1.98

6.8

4.0

6.68

6.53

mmol/l

0.28

565

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.67

1.95

1.0

—

(1616796) Gas panel - Central venous blood

4.67

1.95

4.0

2.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

218

1.73

1.95

5.5

3.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

347

1.63

1.94

5.6

2.7

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

194

1.76

1.93

4.3

2.6

2.46

2.45

mmol/l

0.17

177

(3018095) Leukocytes [#/volume] in Urine

348

1.62

1.91

4.6

3.2

25.75

57.49

e6/l

0.82

240

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.32

1.90

9.2

8.3

1.48

1.32

0.27

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.32

1.90

9.2

8.7

0.65

0.67

0.09

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.76

1.90

3.8

1.9

—

(3002032) Base excess in Venous blood by calculation

2.18

1.88

6.5

2.5

3.78

1.99

mmol/l

1.00

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.64

1.86

6.7

1.9

—

(3026782) Osmolality of Urine

188

1.75

1.85

3.8

2.3

499.08

568.82

mosm/kgh2o

0.92

152

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.27

1.84

1.0

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.27

1.84

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.27

1.84

1.0

1.5

—

(3020891) Body temperature

2.60

1.77

6.6

3.9

—

(3037522) Nuclear Ab [Titer] in Serum

127

1.87

1.76

2.1

1.3

453.33

571.43

titre

—

(3028707) Methadone [Presence] in Urine by Screen method

3.43

1.76

1.0

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.43

1.76

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

808

1.57

1.74

4.2

3.5

15.03

14.70

pmol/l

0.60

720

(3025130) Human papilloma virus identified in Specimen

3.94

1.73

1.6

1.8

—

(3052851) Hemolysis interference index of Serum or Plasma

2.89

1.67

5.9

2.7

—

(3018418) pH of Serum or Plasma

297

1.59

1.64

6.1

3.5

7.41

7.40

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

162

1.74

1.64

2.6

2.5

1.68

1.11

e6/l

0.27

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.66

1.63

1.0

1.2

—

(3044941) Cell count panel - Synovial fluid

3.66

1.63

1.6

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.66

1.63

1.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

3.66

1.63

1.0

1.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

240

1.61

1.55

1.6

1.4

23.73

20.78

nmol/l

0.60

198

(3030467) Casts [#/volume] in Urine by Automated count

275

1.57

1.54

3.9

2.7

0.14

0.39

e6/l

1.53

195

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.41

1.53

1.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.41

1.53

1.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.41

1.53

1.6

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.67

1.53

2.6

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

410

1.51

1.53

2.7

2.1

73.98

78.43

nmol/l

0.58

352

(3035350) Ketones [Presence] in Urine by Test strip

494

1.49

1.53

4.8

3.5

0.00

estimate

-0.00

100

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

118

1059

1.65

1.47

37.3

10.9

28.76

22.39

mg/l

1.12

101

806

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.20

1.45

1.2

1.1

—

(36304419) Bacteria [Presence] in Urine

270

1.55

1.45

4.1

2.6

—

(36660697) Celiac disease serology panel - Serum

1.99

1.45

1.1

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.48

1.41

3.1

1.3

0.20

0.24

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.48

1.41

1.7

1.3

1.09

1.19

g/l

—

(3025941) Bacteria identified in Stool by Culture

2.12

1.37

1.3

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.84

1.29

1.2

1.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

2.84

1.29

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.84

1.29

1.2

1.1

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.94

1.28

4.8

2.2

53.83

69.46

ml/min/173m2

—

(1761868) Lipid panel - Serum or Plasma

415

0.65

1.28

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

714

1.43

1.26

6.7

3.9

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

2.46

1.25

3.0

1.4

83.50

100.14

pmol/l

—

(3011288) Drugs identified in Urine by Screen method

2.46

1.25

1.0

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.83

1.24

2.5

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

218

1.54

1.23

1.4

1.2

5.44

1.02

u/ml

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.69

1.22

1.2

—

(3045414) Leukocytes [Presence] in Urine

2.11

1.17

1.5

1.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.40

1.14

1.0

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

302

1.45

1.13

4.0

2.7

42.87

264.54

e6/l

0.49

221

(3044290) Cell count panel - Cerebral spinal fluid

2.43

1.10

1.8

1.2

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.25

1.09

6.7

4.1

4.11

3.90

mmol/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

181

1.53

1.08

1.3

1.2

16.30

28.17

iu/ml

—

(3021601) Nitrite [Presence] in Urine by Test strip

501

1.38

1.07

6.3

4.7

0.00

estimate

-0.00

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

148

1.57

1.06

2.5

2.6

2.00

2.49

e6/l

0.12

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.02

1.06

8.4

9.5

26.21

24.78

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.69

1.05

5.8

3.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.32

1.04

1.2

1.3

—

(3016879) Cocaine [Presence] in Urine

2.05

1.01

1.0

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

742

1.36

0.99

5.2

2.6

67.19

47.38

u/l

0.81

693

(3004789) Transferrin [Mass/volume] in Serum or Plasma

142

1.56

0.99

4.7

1.9

2.34

2.44

g/l

0.31

130

(3009261) Glucose [Presence] in Urine by Test strip

501

1.34

0.92

5.1

3.5

0.00

estimate

-0.00

(3044889) 12 lead EKG panel

758

1.34

0.91

4.2

3.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.73

0.88

12.9

2.8

1.21

1.23

mmol/l

0.58

(3048689) Calprotectin [Mass/mass] in Stool

121

1.56

0.88

1.8

1.7

202.00

88.90

ug/g

0.97

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

676

1.30

0.80

3.1

2.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.80

0.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.21

0.77

1.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

295

1.34

0.76

5.2

2.9

89.23

264.67

mg/l

0.35

179

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

326

0.72

0.75

4.7

4.0

19.26

21.90

0.51

157

(3028300) Cannabinoids [Presence] in Urine

1.88

0.75

1.1

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.88

0.75

1.0

1.3

—

(3027008) Opiates [Presence] in Urine

1.88

0.75

1.0

1.3

—

(3002256) Pathology report gross observation

135

1.47

0.73

1.4

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

261

1.34

0.71

6.4

3.9

0.00

0.01

estimate

0.49

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

171

1.41

0.71

1.3

13.23

8.19

u/ml

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

1.96

0.71

1.8

1.2

661.20

569.12

mg/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.52

0.69

1.6

1.4

—

(3003694) ABO and Rh group [Type] in Blood

291

1.32

0.67

1.7

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

319

1.31

0.67

4.8

2.7

5.01

7.82

mmol/l

4.19

261

(40761535) Cells panel - Urine sediment

1.60

0.64

8.9

3.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

110

1028

1.30

0.63

26.4

10.9

79.92

81.82

ml/min/173m2

0.33

839

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

125

1.41

0.57

14.4

7.0

—

(3027944) Amphetamines [Presence] in Urine

1.56

0.53

1.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.56

0.53

2.8

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

310

1.26

0.53

6.5

3.3

18.50

5.30

mg/mmol

1.10

179

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

105

987

1.24

0.50

5.4

4.3

1.86

3.19

mu/l

0.54

888

(3001019) Free T4 and TSH panel - Serum or Plasma

1.51

0.48

1.7

1.6

—

(40761536) Microorganisms panel - Urine sediment

1.46

0.47

4.6

3.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.45

0.46

2.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

185

1.29

0.45

1.9

1.5

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.53

0.42

1.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.41

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

245

0.79

0.40

2.7

2.8

0.45

0.75

ug/l

3.05

153

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

111

0.70

0.39

4.3

2.3

—

(3000330) Specific gravity of Urine by Test strip

1.35

0.34

3.5

2.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

107

1113

0.85

0.32

5.5

4.9

2.85

2.76

mmol/l

0.41

100

1022

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.29

0.30

5.1

7.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

130

1.26

0.30

1.6

1.8

1.87

1.47

0.73

118

(3041096) Erythrocytes [Presence] in Urine by Automated

287

0.84

0.28

4.3

3.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

105

1086

0.88

0.24

4.7

4.3

1.47

mmol/l

0.03

1000

(3008898) HLA-B27 [Presence]

1.33

0.23

1.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

106

1094

0.88

0.23

4.9

4.3

4.72

4.66

mmol/l

0.25

100

1012

(40768797) Stomach Pathology biopsy report

135

1.21

0.22

1.1

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

103

0.76

0.22

1.3

1.7

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.21

0.0

1.1

—

99.85

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

1.7

—

12.84

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

273.20

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

114

0.78

0.21

1.3

—

(3000492) Spirometry study

1.23

0.20

1.5

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.20

0.0

1.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.21

0.20

1.3

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

402

0.89

0.20

5.6

4.8

1.37

2.04

ug/l

1.93

354

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.74

0.17

1.4

1.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

207

1.13

0.16

1.3

1.9

451.76

457.70

pmol/l

0.04

173

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

100

0.79

0.14

3.4

2.2

—

(3010813) Leukocytes [#/volume] in Blood

120

1219

0.90

0.12

46.4

16.7

7.11

6.56

e9/l

2.22

114

1186

(40761511) CBC panel - Blood by Automated count

112

1140

0.92

0.11

30.2

10.3

—

(3026361) Erythrocytes [#/volume] in Blood

120

1218

0.91

0.11

46.4

16.7

4.28

4.54

e12/l

5.76

114

1186

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

1011

0.93

0.10

6.9

5.3

41.09

39.51

mmol/mol

0.73

942

(3009542) Hematocrit [Volume Fraction] of Blood

120

1217

0.91

0.10

46.9

16.8

38.26

40.76

3.75

115

1139

(40768443) Skin Pathology biopsy report

1.07

0.09

1.0

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

106

1078

0.94

0.09

5.5

4.4

6.24

5.91

mmol/l

0.66

988

(3020564) Creatinine [Moles/volume] in Serum or Plasma

118

1164

1.08

0.08

35.8

13.3

88.60

76.15

umol/l

0.81

118

1164

(3007461) Platelets [#/volume] in Blood

120

1215

0.92

0.08

46.2

16.7

267.39

247.26

e9/l

1.62

114

1185

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

393

1.06

0.08

6.0

3.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.85

0.08

1.0

1.4

—

(4200892) Spirometry reversibility

1.09

0.07

1.4

1.2

—

(3019060) Gas panel - Arterial blood

1.07

0.07

6.6

3.9

—

(3002385) Erythrocyte distribution width [Ratio]

937

1.04

0.05

29.2

13.9

15.54

14.95

0.37

924

(3022145) Colonoscopy Study observation

117

0.94

0.02

1.0

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

104

1047

0.98

0.01

4.5

3.9

1.35

1.28

mmol/l

0.44

957

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

291

1.00

0.00

1.6

1.33

1.30

mmol/l

0.08

247

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.5

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

155.54

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

66.88

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.02

-0.00

4.0

3.6

4.18

4.72

pmol/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.92

-0.00

2.0

1.6

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

3.0

—

6.96

—

(3022621) pH of Urine by Test strip

0.89

-0.00

3.3

2.7

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

6.5

—

0.58

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.4

—

20.00

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ACTINOMYCOSIS and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_ACTINOMYCOSIS	2.689 [1.86, 3.89]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.106

During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 379 females with AB1_ACTINOMYCOSIS died.

Males

Parameter	HR [95% CI]	p-value
AB1_ACTINOMYCOSIS	2.634 [1.72, 4.04]	< 0.001
Birth year	0.986 [0.92, 1.06]	0.71

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 311 males with AB1_ACTINOMYCOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ACTINOMYCOSIS.

N-year risk	Females	Males
1	0.302%	0.443%
5	1.582%	2.883%
10	3.754%	6.931%
15	7.205%	12.935%
20	12.092%	21.402%

Relationships between endpoints

↥

Index endpoint: AB1_ACTINOMYCOSIS – Actinomycosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Actinomycosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints