Actinomycosis

AB1_ACTINOMYCOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A42 Hospital discharge: ICD-9 — 03[9] Hospital discharge: ICD-8 — 113 Cause of death: ICD-10 — A42 Cause of death: ICD-9 — 03[9] Cause of death: ICD-8 — 113 2 out of 7 registries used, show all original rules.	135
4. Check minimum number of events None	135
5. Include endpoints None	135
6. Filter based on genotype QC (FinnGen only)	135

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_ACTINOMYCOSIS
CONTROL_EXCLUDE	AB1_OTHER_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A42
HD_ICD_9	03[9]
HD_ICD_8	113
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A42
COD_ICD_9	03[9]
COD_ICD_8	113
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Actinomycosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1062	550	497
Only index persons	861	471	390
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	55.29	54.14	56.58
Only index persons	53.82	51.92	56.12

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	135	65	70
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	56.37	52.62	59.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
123: Matched controls
1230

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A42.8

ICD-10 Finland

Other forms of actinomycosis

+∞

28.2

A49.9

ICD-10 Finland

Bacterial infection, unspecified

125.3

28.0

A42.0

ICD-10 Finland

Pulmonary actinomycosis

+∞

25.9

A42.9

ICD-10 Finland

Actinomycosis, unspecified

+∞

24.8

A42.2

ICD-10 Finland

Cervicofacial actinomycosis

+∞

16.0

A41.9

ICD-10 Finland

Sepsis, unspecified

+∞

12.7

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

+∞

11.6

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

+∞

10.6

A42.7

ICD-10 Finland

Actinomycotic sepsis

+∞

9.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

4.5

8.6

11399

ICD-8 Finland

Actinomycosis

+∞

7.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.2

7.1

170

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

8.6

6.8

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

10.1

6.4

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

28.3

6.3

A42.1

ICD-10 Finland

Abdominal actinomycosis

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

13.11

24.05

3.0

1.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

9.80

12.24

1.8

1.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

9.80

12.24

1.9

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

9.80

12.24

1.8

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.74

11.72

2.2

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

5.31

11.53

1.3

2.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

10.96

11.52

1.9

1.2

—

(3022313) Gas panel - Capillary blood

6.75

11.20

9.6

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

10.80

9.67

1.3

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

124

3.73

9.66

2.6

1.6

—

(3042936) Bacteria identified in Isolate by Culture

116

3.58

8.57

4.4

1.9

—

(3028026) IgM [Mass/volume] in Serum or Plasma

4.79

8.55

2.5

1.4

1.1

1.2

g/l

0.28

(3023368) Bacteria identified in Blood by Culture

206

2.97

7.78

8.3

3.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.53

7.47

2.2

1.5

—

(42870588) Differential panel, method unspecified - Blood

306

2.73

7.40

11.9

4.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

409

2.63

7.07

8.2

3.4

33.2

36.1

g/l

2.61

380

(40760888) Immunoglobulin light chains.free panel - Serum

6.96

6.89

1.4

5.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

6.96

6.89

1.5

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.96

6.89

1.2

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.65

6.63

1.2

1.0

—

(3023520) Reticulocytes [#/volume] in Blood

3.54

6.24

2.2

2.8

61.7

66.1

e9/l

0.35

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

5.63

6.13

1.6

1.5

0.3

u/ml

—

(3007853) Bacteria identified in Skin by Aerobe culture

104

3.14

6.05

2.4

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.30

6.01

1.5

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.86

5.98

1.6

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

11.88

5.90

1.9

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

554

2.44

5.83

16.5

8.3

4.2

3.9

e9/l

0.65

489

(3000494) Fungus identified in Specimen by Culture

119

2.96

5.79

2.1

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

13.65

5.66

2.1

1.4

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

13.65

5.66

2.1

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

13.65

5.66

2.1

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

122

2.88

5.52

2.0

1.5

—

(3001604) Monocytes [#/volume] in Blood

473

2.32

5.41

13.7

4.9

0.6

e9/l

1.11

416

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

501

2.32

5.38

12.0

5.0

10.9

umol/l

0.01

464

(3006315) Basophils [#/volume] in Blood

475

2.30

5.33

13.7

5.0

0.0

e9/l

0.45

416

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.53

5.22

4.1

1.5

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

139

2.71

5.19

6.4

2.6

0.8

mmol/l

0.44

130

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.06

5.17

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

10.61

5.11

2.0

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

302

2.31

5.10

4.1

2.0

—

(3019198) Lymphocytes [#/volume] in Blood

492

2.25

5.03

14.3

5.0

1.8

2.1

e9/l

0.84

438

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

9.54

4.86

1.2

1.3

—

(3042631) Mycobacterium sp identified in Specimen

12.04

4.85

2.1

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

232

2.33

4.71

3.9

2.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

8.67

4.64

1.2

1.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

10.53

4.58

1.5

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.15

4.36

3.1

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

360

2.07

4.04

6.1

3.6

33.9

49.4

ng/l

0.61

261

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

100

761

2.21

3.98

16.4

6.1

96.4

77.2

u/l

0.68

698

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

450

2.03

3.96

14.5

5.5

1.2

mmol/l

0.44

374

(40758558) Short blood count panel - Blood

240

2.16

3.94

10.2

6.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.58

3.87

1.2

2.4

—

(4062490)

9.15

3.82

1.6

1.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

300

2.06

3.77

3.7

2.7

36.6

28.7

u/l

0.84

287

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

8.12

3.60

1.3

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.32

3.47

2.2

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.14

3.41

1.4

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

7.31

3.40

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

146

2.26

3.37

2.1

1.9

—

(3019225) pH of Specimen

2.59

3.34

13.7

3.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

6.64

3.22

5.7

2.4

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

3.28

3.17

1.2

2.1

38.3

42.7

u/l

0.28

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

10.31

3.00

1.6

—

(3000991) Gas panel - Venous blood

2.66

2.91

8.7

8.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

6.91

2.90

1.7

1.2

—

(3023419) Bacteria identified in Sputum by Culture

6.91

2.90

2.7

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.91

2.90

2.5

1.1

—

(3032080) INR in Blood by Coagulation assay

386

1.83

2.86

12.6

8.1

1.5

1.2

inr

0.41

112

(4035726)

2.44

2.86

1.7

1.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.65

2.84

1.8

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

4.11

2.83

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

416

1.80

2.77

2.4

2.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

5.21

2.76

5.0

2.5

4.7

4.1

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.21

2.76

5.1

2.6

64.6

54.6

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

5.21

2.76

9.6

2.6

24.6

24.7

mmol/l

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.22

2.72

2.5

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

6.22

2.72

2.5

1.1

—

(3037756) Immunofixation for Serum or Plasma

4.41

2.72

1.1

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

130

2.13

2.67

1.5

1.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

750

1.83

2.65

6.9

3.7

20.0

10.7

mm/h

3.77

681

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

448

1.76

2.64

5.4

3.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

386

1.77

2.60

2.1

1.9

92.6

97.3

pmol/l

0.36

199

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

7.36

2.57

3.2

2.7

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

7.36

2.57

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.38

2.50

4.1

1.9

479.6

380.6

nmol/l

0.60

(21494890) Protein electrophoresis panel - 24 hour Urine

6.44

2.39

1.0

5.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

289

1.78

2.38

2.5

1.9

134.2

185.9

u/l

0.75

269

(3007164) IgA [Mass/volume] in Serum or Plasma

184

1.89

2.31

2.4

1.4

3.0

2.7

g/l

0.27

115

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

4.77

2.29

1.8

1.2

—

(40768795) Lymph node Pathology biopsy report

5.72

2.23

1.4

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.48

2.22

1.5

2.0

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

287

1.73

2.18

5.1

3.0

1081.2

1136.5

ng/l

0.07

232

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

2.09

9.8

5.9

27.3

24.8

mmol/l

0.96

(3016650) Hepatitis A virus Ab [Presence] in Serum

5.14

2.09

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

5.14

2.09

1.4

1.6

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

5.14

2.09

1.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

198

1.81

2.08

1.7

1.6

0.9

mg/l

0.66

155

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.63

2.08

2.3

1.6

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

3.63

2.08

2.1

1.7

84.1

147.3

ug/l

—

(3025159) Blasts/100 leukocytes in Blood

2.29

2.07

5.1

3.8

0.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.85

1.97

3.8

2.0

—

(3021788) Differential panel - Synovial fluid

4.67

1.96

1.6

1.2

—

(3026008) Bacteria identified in Urine by Culture

262

1.69

1.91

4.2

2.7

—

(3026782) Osmolality of Urine

171

1.80

1.90

3.6

2.2

509.5

562.0

mosm/kgh2o

0.54

136

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.28

1.84

1.0

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.28

1.84

1.0

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

4.28

1.84

1.2

1.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.34

1.80

9.9

9.4

0.7

0.01

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.34

1.80

9.9

9.0

1.6

1.3

0.66

(3013512) EKG study

275

1.65

1.78

5.5

3.7

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.13

1.77

5.4

3.7

0.0

0.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.60

1.77

4.0

2.0

0.9

0.7

—

(36660697) Celiac disease serology panel - Serum

2.18

1.77

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

3.44

1.76

1.0

1.3

—

(3052851) Hemolysis interference index of Serum or Plasma

3.02

1.75

6.1

2.8

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.02

1.75

1.0

1.1

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

2.02

1.74

1.7

2.3

7.6

7.0

ug/l

0.04

(3025130) Human papilloma virus identified in Specimen

3.95

1.73

1.6

1.8

—

(3044941) Cell count panel - Synovial fluid

3.95

1.73

1.6

1.2

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.15

1.71

5.5

3.7

0.9

0.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.25

1.68

6.7

3.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

416

1.54

1.63

3.7

2.4

258.9

104.4

ug/l

1.70

380

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.67

1.63

1.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

3.67

1.63

1.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.67

1.63

1.0

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

247

1.62

1.61

3.5

2.7

331.4

8453.5

umol/l

1.52

211

(3011397) Hemoglobin [Presence] in Urine by Test strip

205

1.66

1.59

5.2

3.7

—

(3021589) Normoblasts [#/volume] in Blood

437

1.53

1.58

15.1

8.8

0.0

e9/l

1.04

370

(3018418) pH of Serum or Plasma

284

1.58

1.55

6.2

3.6

7.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

763

1.54

4.2

3.6

15.0

14.7

pmol/l

0.38

679

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.53

1.0

1.2

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.42

1.53

1.6

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.53

1.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.42

1.53

1.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.42

1.53

1.0

1.2

—

(3017181) Myelocytes/100 leukocytes in Blood

1.98

1.52

5.5

3.6

0.9

0.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

330

1.55

1.51

4.9

3.0

2.3

2.4

mmol/l

0.24

290

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.53

1.51

4.1

2.0

1.6

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

152

1.70

1.44

2.7

2.5

1.9

1.1

e6/l

0.33

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

334

1.52

1.43

6.0

2.8

—

(3018095) Leukocytes [#/volume] in Urine

334

1.52

1.43

4.8

3.3

28.3

59.0

e6/l

0.71

230

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.49

1.41

1.0

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

187

1.63

1.38

4.1

2.7

2.5

2.4

mmol/l

0.38

171

(36304419) Bacteria [Presence] in Urine

256

1.55

1.38

4.1

2.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.01

1.37

1.2

—

(3002032) Base excess in Venous blood by calculation

1.98

1.34

6.5

2.5

4.4

1.9

mmol/l

1.22

(3013826) Glucose [Moles/volume] in Serum or Plasma

584

1.46

1.33

6.9

4.0

6.7

6.6

mmol/l

0.11

537

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.57

1.32

2.8

1.2

—

(3020891) Body temperature

2.44

1.31

6.9

4.2

—

(3037522) Nuclear Ab [Titer] in Serum

124

1.72

1.30

2.3

1.3

453.3

557.2

titre

—

(3045414) Leukocytes [Presence] in Urine

2.36

1.29

1.5

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

261

1.52

1.26

4.0

2.7

0.1

0.4

e6/l

1.26

183

(3011288) Drugs identified in Urine by Screen method

2.46

1.26

1.0

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

299

0.61

1.21

3.8

3.7

18.6

22.5

0.70

142

(3035350) Ketones [Presence] in Urine by Test strip

457

1.43

1.20

4.6

3.5

0.0

estimate

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

393

1.43

1.16

2.8

2.1

74.4

78.8

nmol/l

0.53

337

(3044290) Cell count panel - Cerebral spinal fluid

2.56

1.16

1.8

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.56

1.16

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

110

999

1.55

1.15

38.1

11.3

27.2

22.6

mg/l

0.76

762

(3025941) Bacteria identified in Stool by Culture

2.04

1.14

1.3

1.1

—

(1761868) Lipid panel - Serum or Plasma

382

0.66

1.12

2.6

2.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

233

1.49

1.09

1.7

1.5

21.5

20.9

nmol/l

0.08

192

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

139

1.60

1.08

2.6

2.7

2.2

2.9

e6/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

174

1.54

1.05

1.3

16.3

30.1

iu/ml

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

200

1.50

1.05

1.4

1.2

6.0

1.1

u/ml

—

(3016879) Cocaine [Presence] in Urine

2.12

1.04

1.0

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.32

1.04

1.0

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

109

1.64

0.99

1.8

1.7

206.3

91.4

ug/g

0.89

(3019832) Treponema pallidum Ab [Presence] in Serum

1.76

0.99

2.5

1.8

—

(3012544) pH of Venous blood

1.78

0.96

6.7

2.8

—

(3022948) Iron [Moles/volume] in Serum or Plasma

152

1.53

0.96

4.8

2.1

11.6

14.2

umol/l

1.27

140

(3028300) Cannabinoids [Presence] in Urine

1.94

0.95

1.1

1.2

—

(3027008) Opiates [Presence] in Urine

1.94

0.95

1.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

1.94

0.95

1.0

1.3

—

(3015736) pH of Urine

360

1.38

0.92

5.0

3.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.12

0.90

1.8

1.3

1.0

1.2

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.12

0.90

3.5

1.3

0.2

g/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

674

1.33

0.86

6.9

3.9

—

(3002582) Erythrocytes [#/volume] in Urine

292

1.37

0.82

4.1

2.8

44.9

268.4

e6/l

0.47

214

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.80

0.0

1.3

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

143

1.47

0.75

4.8

2.1

2.3

2.4

g/l

0.24

132

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

2.12

0.75

1.8

1.2

661.2

591.5

mg/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

469

1.29

0.71

6.3

4.7

0.0

estimate

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

697

1.28

0.69

5.5

2.7

69.6

46.4

u/l

0.91

650

(3044889) 12 lead EKG panel

708

1.28

0.68

4.0

3.6

—

(3003396) Base excess in Arterial blood by calculation

105

1.48

0.63

8.3

7.4

2.5

1.4

mmol/l

0.42

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

643

1.26

0.62

3.1

2.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

228

0.71

0.61

2.7

0.4

0.7

ug/l

—

140

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.48

0.59

6.3

3.2

—

(3009261) Glucose [Presence] in Urine by Test strip

470

1.25

0.57

5.0

3.5

0.0

estimate

—

(40760892) CBC W Ordered Manual Differential panel - Blood

225

1.31

0.55

10.5

4.2

—

(3027944) Amphetamines [Presence] in Urine

1.61

0.55

1.0

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

263

0.76

0.49

4.7

3.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

121

1.37

0.47

1.6

1.7

1.9

1.5

0.63

109

(40761535) Cells panel - Urine sediment

1.49

0.45

9.6

3.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

167

1.30

0.45

1.3

17.9

8.4

u/ml

—

(3000492) Spirometry study

1.42

0.44

1.4

1.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.58

0.42

1.0

1.4

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.41

0.0

1.3

—

7.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

101

0.68

0.41

3.0

2.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.49

0.41

2.8

1.9

—

(3003694) ABO and Rh group [Type] in Blood

273

1.23

0.40

1.7

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

927

1.21

0.40

5.5

4.4

1.8

3.2

mu/l

0.56

832

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.42

0.38

12.0

3.5

1.2

mmol/l

—

(40768797) Stomach Pathology biopsy report

126

1.31

0.37

1.1

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

100

1046

0.83

0.37

5.5

4.9

2.8

2.7

mmol/l

0.50

955

(3012516) Albumin [Mass/volume] in Urine

285

1.21

0.37

5.0

3.1

71.4

287.2

mg/l

0.45

178

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.38

0.35

2.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

174

1.25

0.34

1.7

1.5

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

365

0.84

0.33

5.1

4.6

1.4

2.0

ug/l

1.48

319

(3001019) Free T4 and TSH panel - Serum or Plasma

1.29

0.32

1.8

1.6

—

(3009508) Creatinine [Moles/volume] in Urine

308

1.18

0.32

4.5

2.9

5.0

7.8

mmol/l

3.68

255

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

101

967

1.18

0.31

25.5

11.3

80.4

81.6

ml/min/173m2

0.16

785

(21494755) Public health laboratory ask at order entry panel

109

0.72

0.30

1.4

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

1030

0.85

0.29

4.9

4.4

4.7

4.6

mmol/l

0.25

948

(3002256) Pathology report gross observation

132

1.24

0.27

1.4

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.23

0.26

4.6

3.2

—

(3029937) Albumin [Presence] in Urine by Test strip

247

1.17

0.25

6.3

3.9

0.0

estimate

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

200

1.18

0.24

1.3

1.9

451.8

462.4

pmol/l

0.07

167

(3000330) Specific gravity of Urine by Test strip

1.33

0.23

3.8

2.7

—

(3008898) HLA-B27 [Presence]

1.33

0.23

1.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

1024

0.88

0.23

4.7

4.3

1.5

mmol/l

0.05

938

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.76

0.23

2.3

2.1

—

(40768443) Skin Pathology biopsy report

1.20

0.21

1.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

1.7

—

12.8

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.21

0.0

1.1

—

19.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

299

1.14

0.21

5.9

3.7

17.3

8.4

mg/mmol

0.58

177

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.20

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.20

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.5

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.21

0.20

5.8

8.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

938

1.12

0.20

24.0

12.5

38.7

40.6

1.16

696

(3010813) Leukocytes [#/volume] in Blood

112

1146

0.87

0.19

46.8

17.2

7.1

6.6

e9/l

1.69

106

1113

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.20

0.18

15.4

7.1

—

(3026361) Erythrocytes [#/volume] in Blood

112

1145

0.87

0.18

46.8

17.1

4.3

4.5

e12/l

4.55

106

1113

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

949

0.90

0.17

6.7

5.5

41.0

39.6

mmol/mol

0.58

883

(3007461) Platelets [#/volume] in Blood

112

1142

0.89

0.15

46.6

17.2

267.6

248.4

e9/l

1.46

106

1112

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

1015

0.91

0.15

5.5

4.4

6.3

5.9

mmol/l

0.67

926

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.82

0.14

1.3

1.8

—

(40761511) CBC panel - Blood by Automated count

105

1070

0.92

0.11

30.6

10.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.09

0.09

4.0

3.6

4.2

4.7

pmol/l

—

(3022621) pH of Urine by Test strip

0.80

0.08

3.8

2.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

366

0.94

0.07

6.0

3.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

110

1093

1.03

0.01

35.8

13.6

88.6

76.8

umol/l

0.67

110

1093

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

987

0.97

0.01

4.5

3.9

1.4

1.3

mmol/l

0.44

898

(3002385) Erythrocyte distribution width [Ratio]

844

1.02

0.00

30.2

14.5

14.0

13.7

1.11

831

(3022145) Colonoscopy Study observation

104

0.96

0.00

1.0

1.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

279

1.00

0.00

1.6

1.3

mmol/l

0.02

237

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.5

—

0.6

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

18.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.90

0.00

1.0

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.90

0.00

7.8

4.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

3.0

—

7.0

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

10.7

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

1.0

—

(4010399)

1.00

0.00

1.4

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.97

0.00

2.0

1.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ACTINOMYCOSIS and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_ACTINOMYCOSIS	2.689 [1.86, 3.89]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.106

During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 379 females with AB1_ACTINOMYCOSIS died.

Males

Parameter	HR [95% CI]	p-value
AB1_ACTINOMYCOSIS	2.634 [1.72, 4.04]	< 0.001
Birth year	0.986 [0.92, 1.06]	0.71

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 311 males with AB1_ACTINOMYCOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ACTINOMYCOSIS.

N-year risk	Females	Males
1	0.302%	0.443%
5	1.582%	2.883%
10	3.754%	6.931%
15	7.205%	12.935%
20	12.092%	21.402%

Relationships between endpoints

↥

Index endpoint: AB1_ACTINOMYCOSIS – Actinomycosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Actinomycosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints