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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_FLOOROFMOUTH_EXALLC for full statistics.

Malignant neoplasm of floor of mouth

C3_FLOOROFMOUTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C04
  • Cause of death: ICD-9 144
  • Cause of death: ICD-8 144
  • Cancer registry: Topography ICD-O-3 C04
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

166

4. Check minimum number of events

None

166

5. Include endpoints

None

166

6. Filter based on genotype QC (FinnGen only)

166

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of floor of mouth based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 166 53 113
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 63.56 64.55 63.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
154
Matched controls
1538
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C04.9
ICD-O-3
Squamous cell carcinoma, NOS, of floor of mouth, NOS
+∞
117.1
97
*
C04.0
ICD-10 Finland
Malignant neoplasm: Anterior floor of mouth
+∞
100.3
85
*
EJB30
NOMESCO Finland
Excision of lesion of floor of mouth
+∞
86.9
75
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
132.4
84.0
85
14
GBB00
NOMESCO Finland
Tracheostomy
200.2
69.7
68
6
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
134.9
57.9
59
7
JDB10
NOMESCO Finland
Percutaneous gastrostomy
155.2
51.6
52
5
C04.1
ICD-10 Finland
Malignant neoplasm: Lateral floor of mouth
+∞
48.5
44
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
583.7
45.8
43
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
166.7
37.6
38
*
EDB00
NOMESCO Finland
Partial excision of mandible
+∞
35.8
33
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
12.3
35.3
72
102
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
9.2
35.2
109
320
C04.9
ICD-10 Finland
Malignant neoplasm: Floor of mouth, unspecified
+∞
34.7
32
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
149.7
34.3
35
*
130
Kela drug reimbursment
Malignant tumour
13.1
34.1
66
83
WF003
NOMESCO Finland
Adjuvant radiotherapy
28.3
32.9
45
22
EP1AE
NOMESCO Finland
Neck ultrasound examination
19.4
32.0
50
37
C04.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of floor of mouth
+∞
29.1
27
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
20.0
28.8
44
30
SAA03
NOMESCO Finland
Extended examination of mouth
7.2
28.6
105
352
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
39.1
27.3
34
11
SBB10
NOMESCO Finland
Teeth copy
17.6
26.8
43
33
EJB60
NOMESCO Finland
Partial excision of floor of mouth
+∞
24.6
23
*
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
282.1
24.4
24
*
A07AA02
ATC
nystatin; oral
13.4
23.8
43
43
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
42.3
23.0
28
8
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
70.5
21.6
24
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
21.6
20.6
30
17
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
15.2
20.3
34
28
8070/3-C04.0
ICD-O-3
Squamous cell carcinoma, NOS, of anterior floor of mouth
+∞
20.2
19
*
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
24.1
19.9
28
14
EBA15
NOMESCO Finland
Extraction of large number of teeth
11.6
18.4
35
38
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
202.3
17.9
18
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
36.3
17.6
22
7
EBB10
NOMESCO Finland
Insertion of dental implant
29.7
17.5
23
9
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.4
17.3
37
50
XX3DW
NOMESCO Finland
Time consuming IT work
7.0
17.2
46
88
EBA10
NOMESCO Finland
Surgical removal of tooth
8.3
16.8
39
60
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
53.8
16.4
19
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
53.8
16.4
19
*
SXC03
NOMESCO Finland
Other oral or dental procedure
67.4
16.1
18
*
ZZA00
NOMESCO Finland
Split skin graft
18.7
15.9
24
15
ECA20
NOMESCO Finland
Biopsy of gingiva
42.9
15.8
19
5
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
15.5
15.3
25
19
K13.78
ICD-10 Finland
Other change in the oral mucosa
24.0
15.1
21
10
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
9.5
14.4
30
38
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
14.4
59
183
TJD20
NOMESCO Finland
Change of gastrostomy tube
59.1
14.1
16
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
15.8
13.7
22
16
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
23.8
13.7
19
9
N02AA05
ATC
oxycodone; systemic
4.7
13.7
54
160
K13.29
ICD-10 Finland
Indefinite leukoplakia
44.2
13.4
16
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
35.4
12.8
16
5
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
76.3
12.8
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
12.7
68
263
8070/3-C04.1
ICD-O-3
Squamous cell carcinoma, NOS, of lateral floor of mouth
+∞
12.7
12
*
K10.26
ICD-10 Finland
Periostitis of jaw (acute)(chronic)(suppurative)
+∞
12.7
12
*
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
8.1
12.3
28
41
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
7.5
12.1
29
46
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
51.0
12.1
14
*
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
51.0
12.1
14
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
8.7
12.1
26
35
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
6.5
11.9
32
60
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
25.3
11.8
16
7
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.4
11.7
86
417
EJC99
NOMESCO Finland
Other reconstructive operations on tongue and floor of mouth
+∞
11.6
11
*
EJW99
NOMESCO Finland
Other operation on tongue or floor of mouth
+∞
11.6
11
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
9.8
11.5
23
27
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
38.2
11.5
14
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
8.0
11.5
26
38
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
22.1
11.4
16
8
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
27.5
11.4
15
6
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
47.0
11.1
13
*
SXC05
NOMESCO Finland
Other oral or dental procedure
7.4
10.6
25
39
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
+∞
10.5
10
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
10.5
10
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
10.5
10
*
A03FA01
ATC
metoclopramide; systemic, rectal
3.7
10.5
54
196
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
25.5
10.4
14
6
SPF00
NOMESCO Finland
Repatation of teeth prosthesis
11.2
10.4
19
19
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
21.8
10.0
14
7
SXA10
NOMESCO Finland
Epithel biopsy of mouth
28.2
10.0
13
5
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
7.1
9.9
24
39
SBA00
NOMESCO Finland
Microbiological examinations
16.4
9.7
15
10
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
32.3
9.6
12
*
UJC01
NOMESCO Finland
Scopy of lower throat
23.5
9.5
13
6
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
9.5
9
*
EJB99
NOMESCO Finland
Other excision on tongue and floor of mouth
+∞
9.5
9
*
EBA00
NOMESCO Finland
Extraction of tooth
3.1
9.4
66
297
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.3
9.4
19
23
SPD05
NOMESCO Finland
Demanding fitting of total teeth prosthesis
39.2
9.1
11
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
20.1
9.1
13
7
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
10.5
9.0
17
18
ZXE40
NOMESCO Finland
More than seven and less than nine hours
11.7
9.0
16
15
WX110
NOMESCO Finland
Local anesthesy
3.0
8.9
114
750
QAB05
NOMESCO Finland
Revision of wound of skin of head or neck
53.1
8.8
10
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
21.5
8.6
12
6
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
29.4
8.6
11
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
29.4
8.6
11
*
R13
ICD-10 Finland
Dysphagia
5.5
8.6
25
52
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
11.7
8.5
15
14
D83
ICPC
Mouth/tongue/lip disease
95.0
8.5
9
*
K10.20
ICD-10 Finland
Osteomyelitis (neonatal) of jaw (acute)(chronic)(suppurative)
95.0
8.5
9
*
GD6AD
NOMESCO Finland
CT of chest and neck
95.0
8.5
9
*
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
+∞
8.4
8
*
EDB20
NOMESCO Finland
Hemimandibulectomy
+∞
8.4
8
*
WX707
NOMESCO Finland
Fiberoscopic intubation
+∞
8.4
8
*
D10.2
ICD-10 Finland
Benign neoplasm: Floor of mouth
+∞
8.4
8
*
J02AC01
ATC
fluconazole; systemic
2.9
8.4
64
302
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.2
8.4
22
40
N07BA03
ATC
varenicline; oral
6.2
8.4
22
40
K05.31
ICD-10 Finland
Periodontitis pronounced
4.5
8.3
30
79
EKA10
NOMESCO Finland
Biopsy of cheek
9.8
8.3
16
18
EB1WA
NOMESCO Finland
NA
35.4
8.2
10
*
R4190
NOMESCO Finland
Nutritional therapy
8.5
8.1
17
22
SPF30
NOMESCO Finland
Soling for prothesis
11.7
8.0
14
13
N05AA02
ATC
levomepromazine; systemic
8.2
7.9
17
23
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
47.4
7.8
9
*
ECB20
NOMESCO Finland
Oral alveoplasty
19.6
7.7
11
6
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.1
7.7
24
54
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
7.5
7.5
17
25
EDW99
NOMESCO Finland
Other operation on mandible
84.0
7.5
8
*
R4130
NOMESCO Finland
Speech therapy
11.7
7.5
13
12
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
+∞
7.3
7
*
JDB00
NOMESCO Finland
Gastrostomy
+∞
7.3
7
*
C06.9
ICD-10 Finland
Malignant neoplasm: Mouth, unspecified
+∞
7.3
7
*
EJB40
NOMESCO Finland
Hemiglossectomy
+∞
7.3
7
*
EDC42
NOMESCO Finland
Mandibular repair with implant
+∞
7.3
7
*
SPF20
NOMESCO Finland
Temporary soling for filling
16.8
7.3
11
7
SPD01
NOMESCO Finland
Mucosa-supported complete denture
21.2
7.2
10
5
Z50.5
ICD-10 Finland
Speech therapy
21.2
7.2
10
5
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
31.6
7.2
9
*
Z51.5
ICD-10 Finland
Palliative care
4.8
7.1
23
54
N05AB01
ATC
dixyrazine; systemic
14.7
7.0
11
8
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
11.7
6.9
12
11
ZX070
NOMESCO Finland
Intensity modified radiotherapy
11.7
6.9
12
11
GD1AD
NOMESCO Finland
Thorax CT examination
5.1
6.9
21
46
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.6
6.9
23
56
D20
ICPC
Mouth/tongue/lip symptom/complaint
7.0
6.8
16
25
WX872
NOMESCO Finland
Intensive care
5.0
6.8
21
47
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
23.7
6.8
9
*
WX402
NOMESCO Finland
General anaesthesia
3.1
6.7
40
156
SAA01
NOMESCO Finland
Simple examination of mouth
2.5
6.5
107
738
A04AD12
ATC
aprepitant; systemic
15.2
6.5
10
7
SPA60
NOMESCO Finland
Fitting of intermediary dental prosthesis structures, 1 to 3 units
15.2
6.5
10
7
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
6.2
6.3
16
28
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
27.9
6.3
8
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
27.9
6.3
8
*
Z43.1
ICD-10 Finland
Attention to gastrostomy
+∞
6.3
6
*
SCB02
NOMESCO Finland
Training for mouth care at home
+∞
6.3
6
*
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
+∞
6.3
6
*
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
6.3
6
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
10.7
6.1
11
11
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
10.7
6.1
11
11
SPD00
NOMESCO Finland
Fitting and preparation of total teeth prosthesis
10.7
6.1
11
11

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_FLOOROFMOUTH – Malignant neoplasm of floor of mouth

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).