adrenal gland disease: A disease involving the adrenal gland.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
219 |
4. Check minimum number of eventsNone |
219 |
5. Include endpointsNone |
219 |
6. Filter based on genotype QC (FinnGen only) |
219 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E27
- Name in latin
- Alia hyperfunctio adrenocorticalis
Similar endpoints
↥List of similar endpoints to
Other adrenocortical overactivity
based on the number of shared cases.
Similar with more cases:
- Other disorders of adrenal gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4574 | 3566 | 1002 |
| Only index persons | 3335 | 2615 | 720 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.03 |
| Only index persons | 0.08 | 0.10 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 7.91 | 7.69 | 8.52 |
| Only index persons | 8.08 | 7.85 | 8.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 219 | 183 | 36 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 14.57 | 8.40 | 45.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 191
- Matched controls
- 1911
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
239.3
176
*
H02AB09
ATC
hydrocortisone; systemic
24.6
35.1
50
27
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
27.8
26
*
H02AA02
ATC
fludrocortisone; oral
+∞
22.3
21
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
22.3
21
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
13.1
18.6
33
30
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
15.8
15
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
173.6
15.7
16
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
12.6
12
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
138.7
12.6
13
*
25508
ICD-8 Finland
Diseases of adrenal glands, Hyperfunctio adrenocorticalis alia
+∞
11.6
11
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
8.5
9.4
20
26
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
52.4
8.8
10
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.2
8.4
22
39
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
8.4
8
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
8.4
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
7.4
48
197
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
7.3
7
*
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
+∞
7.3
7
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
7.3
7
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
7.3
7
*
M05BA04
ATC
alendronic acid; oral
7.3
6.7
15
22
H02AB07
ATC
prednisone; oral
4.1
6.4
24
65
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
E24.8
ICD-10 Finland
Other Cushing syndrome
+∞
6.3
6
*
E66.01
ICD-10 Finland
Obesity due to excess calories
3.7
6.0
25
74
H03AA01
ATC
levothyroxine sodium; systemic
2.7
6.0
44
193
C03CA01
ATC
furosemide; systemic
3.2
6.0
31
109
Mortality – FinRegistry
↥Association
Association between endpoint E4_ADREACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ADREACT | 4.569 [3.1, 6.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.084 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 2952 females with E4_ADREACT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_ADREACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.47% | No data |
| 5 | 2.272% | No data |
| 10 | 5.762% | No data |
| 15 | 11.548% | No data |
| 20 | 18.618% | No data |
Relationships between endpoints
↥Index endpoint: E4_ADREACT – Other adrenocortical overactivity
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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